41 results about "Dermatological diseases" patented technology

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

The application discloses an animal model and a detection method for evaluating the effects of a substance on hair growth and / or coloring. The evaluation steps are as follows: the experimental animal is plucked, and then the substance to be evaluated is injected into the tentacle pad or the mustache pad or the hair follicle cavity on one side of the experimental animal, and a control solution is injected into the tentacle pad or the mustache pad or the opposite symmetrical hair follicle cavity on the other side of the experimental animal; after a certain number of injections, the hair on the side injected with the control solution grows, while the hair on the side injected with the solution containing the substance to be evaluated grows or does not grow; the length and / or coloring of the grown hair are quantitatively detected and compared, so that the effects of the substance on hair growth and / or coloring can be accurately evaluated. The application utilizes the symmetry of the hair of the experimental animal, and a simple, direct and high-sensitivity method for quantitatively evaluating the effects of a substance on hair growth in vivo is obtained, which can be used for the research on skin diseases and the development of related drugs, cosmetics and the like, and has important scientific significance and application value.

This invention relates to a phototherapy device for skin diseases, comprising a base unit, several adjustment units, several mounting units, several phototherapy units, and several covering units. Its advantages include: the base unit provides a mounting foundation, allowing for placement in homes or community medical institutions, overcoming the location limitations of whole-body phototherapy devices that can only be used in specific hospital departments; the sliding cooperation between the adjustment units and the base unit enables the horizontal reciprocating movement of the mounting units, allowing adjustment of the phototherapy unit's position according to the patient's needs; and the detachable connection between the phototherapy units and the mounting units facilitates the replacement of phototherapy units of different sizes according to the area of ​​skin lesions. Patients can complete treatment independently at home without frequent trips to the hospital, reducing time costs and the burden of treatment cycles. It also avoids the embarrassment of full-body exposure in public places like hospitals, alleviating situations where patients interrupt treatment due to privacy concerns.

1. Name of the design product: smoking device (for skin disease laser treatment). 2. Use of the design product: to achieve efficient smoke exhaust, reduce noise in the working environment, and optimize the operating environment in skin disease laser treatment. 3. Design points of the design product: the combination of shape and pattern. 4. Picture or photo that best indicates the design points: front view.

This invention provides a skin condition detection method and system based on image recognition. The method includes acquiring a skin image to be analyzed and related textual metadata; inputting the preprocessed image into a trained skin lesion segmentation model and outputting the segmentation result of the lesion region; automatically extracting the size information and at least one morphological quantitative feature of the skin lesion based on the segmentation result, and integrating the size information and the morphological quantitative feature as supplementary features into the textual metadata to form enhanced metadata; assigning appropriate weights to the image features and the textual features based on the mutual information between the image features and the textual features, and dynamically weighting and concatenating them to form a fused feature vector; inputting the fused feature vector into a classifier and outputting the classification result of the skin condition, which significantly improves the model's ability to distinguish similar skin diseases, especially early malignant lesions, and improves the classification accuracy.

The application discloses a skin disease diagnosis and treatment scheme generation method and a generation system. The generation method comprises the following steps: acquiring a plurality of skin lesion images and medical record text content of a patient; determining the overall skin lesion condition and pathogenesis of the patient based on the acquired plurality of skin lesion images and in combination with a skin disease representation model, wherein the skin disease representation model is constructed based on a general multi-modal large model; determining the diagnosis condition and treatment scheme of the skin disease based on the acquired plurality of skin lesion images and medical record text content, the determined overall skin lesion condition and pathogenesis, and in combination with a skin disease reasoning model, so as to generate the diagnosis and treatment scheme of the skin disease, wherein the skin disease reasoning model is constructed based on the skin disease representation model. In this way, the diagnosis and treatment process of the skin disease is simplified, and the diagnosis and treatment efficiency is improved.

1. Name of the product in this design: Ultraviolet Therapy Device (308nm). 2. Purpose of this design: A physical therapy instrument for treating skin diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

This invention proposes an antifungal dermatitis agent containing peony bark, white peony root bark, and sophora flavescens, its preparation method, and its application, belonging to the field of veterinary drug technology. It includes an active ingredient and other pharmaceutically acceptable excipients. The active ingredient comprises a traditional Chinese medicine extract and an antifungal compound in a mass ratio of (50-100):1. The traditional Chinese medicine extract is obtained by extracting peony bark, white peony root bark, and sophora flavescens in a mass ratio of (1-3):(2-5):(2-4). The antifungal compound has the structural formula shown in Formula I or a pharmaceutically acceptable salt thereof.

This invention discloses a fusion protein, Mfp-ELP, with ultraviolet (UV) damage repair function and its applications, belonging to the field of biomedical technology. The amino acid sequence of the fusion protein Mfp-ELP is shown in SEQ ID No: 1. This invention, through optimized gene design, expression system, and purification process, achieves a simple, easy-to-implement, high-purity, and low-cost preparation method with good water solubility, stability, compatibility, and biocompatibility, facilitating large-scale production. It can significantly promote the proliferation of HSF cells and UVB damage repair, accelerate the healing rate of full-thickness skin defects in mice, reduce photodamage to HSF cells, alleviate UV-induced photoaging and sunburn, and exhibit significant antioxidant activity and efficacy in reducing cell and skin sunburn. It can be widely used in drugs, medical biomaterials, and cosmetics for anti-photoaging and / or promoting skin sunburn repair and / or adjuvant treatment of photodamaged skin diseases.

The application relates to the technical field of medicines, health foods or cosmetics, in particular to application of an Artemisia argyi extract in preparation of cosmetics or medicines for treating dry skin diseases. Compared with the prior art, the Artemisia argyi extract as a natural plant extract emollient has safety and effectiveness, the plant active ingredient has the advantages of multi-target point, long-term use safety and excitation of the skin self-repairing ability, and the like, and exhibits good effects in improving dry skin, and overcomes many limitations of traditional emollients, and provides a more effective strategy for treating dry skin.

A composition for improving skin comprising extracts of Polygala tenuifolia, Angelica dahurica and Elsholtzia splendens is described. The composition is excellent in effects of improving skin inflammation, antioxidant effects, antibacterial effects on skin, and skin moisturizing effects, and thus can be used as a cosmetic for improving skin, and further, as a pharmaceutical composition for treating inflammatory skin diseases.

The present disclosure relates in some aspects to compositions, such as pharmaceutical compositions for topical administration, which are useful for treating or preventing hair loss, hair graying, and dermatological conditions in a subject, such as comprising a terpene, for example farnesol. Also provided are kits comprising the compositions, and methods of using the compositions for treating or preventing hair loss, hair graying, and dermatological conditions.

The present invention relates to a dermatological or cosmetic skin composition in the form of a paraffin-free emulsion, particularly suitable for the treatment of inflammatory skin diseases, especially sensitive or atopic skin. The composition comprises an aqueous phase containing at least one emollient selected from polyols, and an oil phase containing an oily emollient system comprising at least 70% by weight of safflower oil and a second oily emollient.

The application discloses a kind of based on dynamic retrieval and chain reasoning's auxiliary diagnosis method, device and medium of dermatosis.It is described as follows:The method includes: obtaining skin disease image and user description text;First visual language model is input to target sample, and medical entity feature is extracted and primary diagnosis hypothesis is generated;According to the clinical diagnosis sequence of mechanism inference from feature perception, generate reasoning node sequence;Based on current node and reasoning context, construct retrieval query, retrieve reference information in skin disease knowledge base and integrate with reasoning node, form image-knowledge-reasoning chain triple knowledge structure;The integration result of the reasoning node sequence and the triple knowledge structure is input into second language model, and auxiliary diagnosis report containing diagnosis reasoning process and diagnosis conclusion is generated and output.No skin disease image-diagnosis report pairing training data can improve the explainability and reliability of zero sample diagnosis.The application also provides the corresponding diagnostic device and computer readable medium.

The present disclosure provides an image processing method, device, medium and electronic equipment for skin disease diagnosis, relating to the technical field of image processing. The method comprises: acquiring skin images of a patient's same region skin under at least two modalities through a skin examination device; determining a feature category corresponding to the skin images, and performing feature extraction for each skin image respectively for the feature category to obtain a feature image set corresponding to the skin images; registering the feature images in the feature image set to obtain a registered feature image set; and fusing the registered feature images to obtain a multi-modal fusion image. The present disclosure can provide more comprehensive and more prominent feature patient skin data to doctors or diagnosis and treatment systems by acquiring multi-modal skin images for fusion to obtain a multi-modal fusion image, thereby overcoming the defect that a single modal image cannot comprehensively represent skin features, and improving the comprehensiveness and integrity of the skin disease diagnosis result.

The invention relates to methods of treatment and / or prevention of an inflammatory skin disease in a subject, wherein the therapeutic effects persist for at least 24 weeks or more after the last administration of the composition of the invention. Also disclosed are kits and methods of treating and / or preventing an inflammatory skin disease using said composition.

The present invention provides compositions comprising ruscogenin. The compositions of the present invention can be topically applied to the skin of a subject. The present invention further provides methods of applying compositions comprising ruscogenin to improve or treat a skin condition. The compositions of the present invention can also be applied to improve the overall appearance of the skin.

The present invention relates to a therapeutic device that emits multi-frequency ultrasound, and more specifically, to a skin disease treatment device capable of alternately or selectively emitting ultrasound of multiple frequency bands within the range of 0.6 MHz to 20 MHz from an ultrasound transducer when performing ultrasound treatment using an ultrasound transducer in contact with the surface of human skin, particularly the skin of the face. Unlike conventional ultrasound transducers that emit only ultrasound of a single frequency band, a single ultrasound transducer is used that alternately or selectively emits ultrasound of multiple frequency bands within the range of 0.6 MHz to 20 MHz. Specifically, a high-frequency generating ultrasound transducer that generates a waveform with a large amplitude and a short period (high frequency band), a low-frequency generating ultrasound transducer that generates a waveform with a relatively smaller amplitude and longer period than the high-frequency generating ultrasound transducer (low frequency band), and a medium-frequency generating ultrasound transducer in the intermediate frequency band can be replaced by a single ultrasound transducer. Since high-frequency, medium-frequency, and low-frequency ultrasounds can be selectively or alternately generated, this device is suitable for specialized skin hospitals or skin massage clinics. Since it is possible to perform skin treatment with optimal ultrasound using a minimal number of ultrasound devices without having to equip a business with various types of ultrasound devices, individuals, specialized skin clinics, or specialized skin massage businesses can minimize the purchase cost of ultrasound devices and reduce maintenance costs. Additionally, by generating high-frequency, medium-frequency, and low-frequency ultrasounds tailored to the lesions, it can have an excellent effect in treating lesions that have been difficult to treat until now, such as intractable rosacea and acne.

The application discloses a marine red alga polysaccharide extract and application thereof, and belongs to the technical field of marine organisms and medicines. Gigartina radula The polysaccharide extract is extracted from marine red algae, and the main component is natural galactosamine sulfate, contains galactose and glucose, has a sulfate content of 20-40%, a 3,6-endo ether galactose content of 20-50%, and a viscosity of 80-400 mPa s. The polysaccharide extract contains kappa-carrageenan structural units, iota-carrageenan structural units, mu-carrageenan structural units, nu-carrageenan structural units and lambda-carrageenan structural units, and the proportion of the lambda-carrageenan structural units is 10-50%. The marine red alga polysaccharide extract can be applied to the preparation of medicines or functional skin care products for preventing and / or treating inflammatory and immune-related skin diseases such as atopic dermatitis AD.

The present application belongs to the field of microbial technology, and more specifically, the present application relates to an inactivated culture of plant lactobacillus BGI-N6, its use and products containing the inactivated culture. The present application provides an inactivated culture product of probiotics, which can break through the condition limitation of application of active probiotics, effectively eliminate free radicals, inhibit collagenase and elastase, inhibit skin pathogenic bacteria, so as to achieve better effect of slowing down skin aging.

The present invention relates to isocetyl stearyloxy stea rate for use in enhancing and / or preventing a decrease in epidermal barrier function, in particular for use in enhancing the protection of the skin against pollution. The present invention also relates to a cosmetic or dermatological composition comprising isocetyl stearyloxy stearate and at least one cosmetically or dermatologically acceptable excipient for use in enhancing and / or preventing a decrease in epidermal barrier function, in particular for use in enhancing the protection of the skin against pollution.

The present invention provides: a composition comprising a Nephelium lappaceum extract extracted with an extraction solvent comprising a natural deep eutectic solvent (NADES); and a preparation method therefor. Specifically, the present invention comprises a cosmetic composition for improving the condition of the skin and a pharmaceutical composition for preventing or treating inflammatory skin diseases, each comprising a Nephelium lappaceum extract extracted with an extraction solvent comprising a natural deep eutectic solvent.

The present invention relates to a cosmetic or dermatological composition and to the use thereof, in particular for enhancing and firming the skin, and combating a dull complexion. The cosmetic or dermatological composition comprises, in % by weight relative to the total weight of the composition, from 3 to 4% by weight of at least one vegetable oil rich in essential polyunsaturated fatty acids; a combination of 0.002 to 0.02% of a copper salt, 0.02 to 0.2% of a zinc salt, and 0.02 to 0.2% of a magnesium salt; a myrtle essential oil; and vitamin C and / or a derivative thereof. The present invention also relates to a cosmetic treatment method comprising a step of applying an effective quantity of the composition to a person's skin.

Methods and compositions are provided that enable users to interact with a multimodal digital health platform to assess inflammatory skin conditions, including eczema. Screening for contact allergies is performed with a transdermal adhesive device to deliver contact allergens for epicutaneous patch tests, herein termed a “Contact Allergen Panel”. Automated detection and interpretation may use machine learning based on image feature extraction and integration with allergen skin-sensitizing potency and significance to provide an analysis of reactivity to an allergen of interest.

The present invention provides cosmetic compositions and methods comprising a composition derived from a lotus plant effective to treat, reduce, ameliorate and / or eliminate signs and results of dermatological aging of the skin and / or to improve the aesthetic appearance of the skin. Further, the composition is provided for use in compositions and methods to treat, ameliorate and / or reduce hyperhidrosis (or sweating or perspiration), particularly facial perspiration. More particularly, the active composition is an extract of lotus and / or a blend of extracts of various species of the lotus family, such as NELUPURE (INCI: Propanediol (and) Glycerin (and) Nymphaea Caerulea Flower Extract (and) Nelumbo Nucifera Flower Extract). This active reduces sebum and perspiration and is used to provide cosmetic long-lasting compositions.

The present invention relates to the technical field of veterinary medicinal products, in particular a composition for the treatment of a skin disease in an animal. The main active ingredients of the composition are rapamycin, miconazole, and meloxicam in a mass ratio of (0.01–10):(0.1–20):(0.1–5) and a mixed solvent of water and dimethylacetamide in which the main active ingredients are soluble. The composition has a significant curative effect on fungal infections on the skin surface of animals, with low toxicity and minimal irritation.

This invention relates to a verbena extract and compositions containing the verbena extract, which are used in the fields of cosmetics and dermatology, and in the field of hair care, particularly for the prevention and / or treatment of hair loss or for promoting hair growth.

The present invention relates to a composition, in particular a cosmetic or dermatological composition, comprising at least one aqueous phase, at least one water-soluble organic UV-screening agent and at least one thiopyridinone compound of given formula, and / or the optical isomers or geometric isomers thereof and also the organic or mineral acid or base salts thereof, and / or solvates thereof, such as hydrates.

A serine protease derived from M. luteus. is disclosed. Also disclosed are compositions comprising the serine protease and associated uses and method of manufacture.