275 results about "Dermatological diseases" patented technology

The invention discloses a skin disease diagnosis method based on image recognition, and the method comprises the following steps: obtaining a to-be-detected skin image, and recording an equipment identifier; carrying out white balance correction, reflection suppression, hair suppression and scale normalization to generate a standardized image; positioning the focus to generate a focus mask; generating an enhanced view set in the focus mask by the enhanced view set according to the enhanced times and the enhanced view set; calculating a color invariant graph, a sign response graph and an artifact confidence graph, and synthesizing a potential energy field set according to a fusion weight; calculating a local structure tensor and generating a Riemannian metric matrix; constructing an improved Morse-Smal complex under a Riemannian metric matrix, carrying out cross-complex clustering on the critical point set to obtain a stable score, carrying out complex simplification to generate a stable Morse-Smal complex, and calculating the confidence coefficient of the cell boundary; and extracting structured feature vectors, diagnosing, judging and outputting disease categories, grading results and re-checking and marking. According to the invention, the anti-artifact and cross-device stability is improved.

The invention provides a skin lesion auxiliary detection method and system based on multi-modal information fusion, and belongs to the technical field of computer vision and application. The method comprises the following steps: firstly, acquiring and constructing bimodal data including a dermatoscope image and a text of a patient, and preprocessing the data; secondly, respectively adopting an improved convolutional neural network and a text coding model, and extracting deep and high-dimensional features from the skin disease image and the self-described text of the patient; afterwards, an improved symmetric gating cross attention fusion module is constructed, fine-grained interaction and alignment between visual and text features are realized through a bidirectional cross attention mechanism, and a gating unit is utilized to adaptively adjust a fusion weight; and finally, inputting the deeply fused multi-modal feature vector into a classifier to obtain a confidence score of each skin lesion type so as to provide reference for dermatologists. According to the method, the diagnosis accuracy, robustness and interpretability are synergistically improved, and the method has great clinical application value.

The invention belongs to the technical field of medical image and big data analysis, and provides an automatic skin disease diagnosis method and system based on a multi-modal big language model, and the method comprises the steps: obtaining a dermatoscope diagnosis report of a historical patient, and extracting an original image and a diagnosis text in the dermatoscope diagnosis report; constructing a multi-modal large language model, wherein the multi-modal large language model comprises a visual encoder, a linear projection layer and a large language model; training the multi-modal large language model; obtaining an external medical knowledge base, extracting text information in the external medical knowledge base, and constructing a vector database based on the text information; in response to an input image and a query text of a user, N vectors with the highest similarity are retrieved in the vector database according to the query text, the retrieved vectors are decoded into a text, and the text and the query text jointly construct complete prompt word input; and based on the input image and cue word input, obtaining a final dermatoscope diagnosis report by using the trained multi-modal large language model. The diagnosis report is automatically generated.

The invention relates to the technical field of intelligent medical assistance, in particular to a skin disease treatment electrode positioning system based on potential distribution. The system comprises a potential gradient severe region identification module, a lesion minimum surrounding region identification module, a similar potential region grouping module, an optimal electrode position prediction module, an electric field distribution calculation module, a sweat gland dense region identification module, an optimal electrode placement point screening module, an enhanced feature generation module and a final electrode position determination module. By fusing multi-source information such as skin surface potential distribution, lesion geometric characteristics, tissue conductivity, historical treatment data and the like, systematic optimization is performed on electrode positioning in skin disease treatment, the effectiveness of electrode stimulation is maximized on the premise of ensuring the treatment safety, and the treatment efficiency is improved. An accurate electrode placement scheme is provided for treatment of different types of skin diseases, and the method is suitable for accurate determination of the electrode placement position in electrical stimulation treatment.

The invention relates to the technical field of animal cub culture, in particular to an animal cub culture device for animal husbandry veterinarians, which comprises a culture box, a transparent door plate slidably connected to the culture box, a hollow plate inserted into the culture box, an excrement groove hung at the rear end of the culture box, a diversion groove formed in the lower end in the culture box, and a discharge groove formed in the rear wall of the culture box. The driving assembly is located in the incubator and comprises two movable blocks, the upper ends of the movable blocks are fixedly connected with push blocks, a guide rail is fixedly arranged on the top face of the upper end of the incubator, the upper ends of the two push blocks are slidably connected with the guide rail, and the outer walls of the two sides of each movable block are communicated with a plurality of nozzles. The flushed and disinfected area is dried through hot air, the cleaning effect of excrement of the cubs is improved, excrement residues are reduced, bacterium breeding is reduced, a healthy environment is provided for cub culture, and the morbidity of diarrhea, skin diseases and the like of the cubs is reduced.

The invention provides a compound of formula (I)wherein:A, B, C, D, W, X, Y and Z are each independently selected from H and OH;or a salt thereof;for use in the treatment and / or prevention of a skin condition in a subject, wherein the compound of formula (I) or salt thereof is administered topically. The invention further provides topical compositions of a compound of formula (i) and processes for the preparation of said compositions.

The invention provides systems and methods for diagnosing and treating an inflammatory skin disease in a patient. The described methods may be used for longitudinal monitoring of the development, progression, or regression of a skin disease including lupus, psoriasis, atopic dermatitis, and systemic sclerosis (scleroderma) condition in a patient, in response to a therapy administered for the condition.

The invention discloses a percutaneous barrier function evaluation method and system based on precise temperature and humidity control. The method comprises the steps that S1, an individualized skin barrier baseline model containing daytime fluctuation characteristics and temperature and humidity sensitivity parameters and a baseline database are constructed; s2, executing an environment adaptability evaluation scheme through dynamic temperature and humidity spectrum scanning; s3, multi-dimensional skin physiological parameters are collected, a static parameter set and a dynamic parameter set are distinguished, and data standardization is achieved through dynamic baseline subtraction and cross-parameter interference compensation by adopting a physiological constraint type data correction algorithm based on a skin physiological relevance matrix; s4, integrating the standardized parameters to calculate a comprehensive barrier function index; and S5, predicting a barrier function trend. The system comprises a precise environment control module, a multi-parameter acquisition module, an intelligent analysis module, a data storage and interaction module and a central processing module, the accuracy and comprehensiveness of percutaneous barrier function evaluation can be improved, and technical support is provided for skin health management, skin disease diagnosis and treatment and the like.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine decoction for treating vitiligo and a preparation method thereof.The traditional Chinese medicine decoction for treating vitiligo is prepared from ten medicinal materials including notopterygium root, divaricate saposhnikovia root and the like according to the core pathogenesis of vitiligo rheumatism stagnated heat syndrome, the brand new theory of treating both black and white diseases and both black and white diseases is creatively provided, and on the basis of the theory, the traditional Chinese medicine decoction for treating vitiligo is prepared into the traditional Chinese medicine decoction for treating vitiligo. White spots and surrounding deepened skin are brought into systematic conditioning for the first time, the formula is compatible with black and white medicine pairs, black is used for treating white, white is used for treating black, overall conditioning and two-way adjustment are achieved, the white spots can recover to the normal skin color, and due to the innovative application of the two groups of black and white medicine pairs (wine-processed rhizoma chuanxiong, radix angelicae sinensis, radix rehmanniae preparata and radix paeoniae alba) in the formula, black is used for treating white, white is used for treating black, and two-way adjustment is achieved. And meanwhile, the clinical piebald skin disease symptom is also eliminated, so that the white spots recover to the normal skin color.

The present invention provides a composition comprising a pectolinarigenin, a method for preparing the pectolinarigenin, and a method for preparing the pectolinarigenin. The compositions of the present invention can be topically applied to the skin of a subject. The invention further provides methods of administering a composition comprising pectolinarigenin to ameliorate or treat a skin condition. The composition of the present invention can also be used to improve the overall appearance of the skin.

The utility model relates to a hydropathic compress instrument for skin disease nursing. The hydropathic compress instrument comprises a bridle and an atomization main body, a barrel shell is mounted in the middle of the length of the bridle, a dividing disc is fixedly arranged in the barrel shell with an open structure, and the barrel shell is divided into a containing space and an atomizing space communicated with the open structure by the dividing disc; the bridle is bound on a body part of a patient, the open structure is buckled on a skin lesion part area to drive the atomization main body and the spray gun to start working, the atomization main body atomizes a solution containing a medicament into gas, the gas is sprayed to the skin lesion part area, and then skin disease wet compress nursing is achieved. By means of the structure, the situation that a spray gun is manually held by hand is avoided, a fixed structure is adopted to replace the situation that the spray gun is manually held by hand, an atomized solution can be accurately sprayed to a skin lesion part, the solution is evenly distributed, and the situation that the solution in an edge area is insufficient possibly due to manual holding is avoided.

The present invention relates to esters of formula (I) or pharmaceutically acceptable salts thereof and their use as medicaments, in particular for the treatment of skin diseases or skin cancer. The present invention further relates to the use of esters of formula (I) or pharmaceutically acceptable salts thereof in cosmetic and nutritional compositions for preventing or reducing the signs of aging in healthy subjects.

The invention relates to the technical field of skin medicines, in particular to a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The invention discloses a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The composition comprises active ingredients of astacin and derivatives thereof, p-toluene sulfonamide and derivatives thereof, and pharmaceutically or cosmetically acceptable excipients. Through the synergistic effect of the two active components, the composition can effectively inhibit skin inflammatory response, relieve pruritus and erythema and promote skin barrier repair and wound healing. The composition can be prepared into multiple external dosage forms such as cream, gel and spray, is suitable for preventing or treating multiple inflammatory skin diseases such as atopic dermatitis, eczema and psoriasis, and can also be used for repairing and nursing skin wounds. The external formula provided by the invention has both curative effect and safety, and provides a new choice for the treatment of inflammatory dermatosis.

The invention relates to the technical field of skin disease classification, in particular to an auxiliary skin disease classification method and system based on multi-modal medical data, and the method comprises the steps: extracting features of a plurality of types of first data, and obtaining a plurality of initial feature vectors; performing low-level fusion and high-level fusion according to the plurality of initial feature vectors to obtain a comprehensive feature vector, inputting the comprehensive feature vector into a classifier, and determining a predicted skin disease category; and generating a diagnosis report according to the predicted skin disease category. According to the invention, low-level fusion and high-level fusion are carried out according to the plurality of initial feature vectors to obtain the comprehensive feature vector, and the predicted skin disease category is determined by fusing the data of the plurality of categories of the skin diseases and inputting the comprehensive feature vector into the classifier, so that the accuracy of skin disease classification is improved.

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

The present invention relates to cosmetic and / or dermatological preparations containing propylene glycol.

The present invention relates to a cosmetic or dermatological ingredient or a cosmetic or dermatological composition comprising the peptide of sequence SEQ ID N ° 1 and / or a derivative thereof and / or a salt thereof, and to the uses thereof for improving the condition and / or appearance and / or comfort of healthy skin and / or healthy mucous membranes and / or healthy skin appendages.

The application belongs to the technical field of medicines, and specifically provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases include atopic dermatitis and skin epidermal barrier damage. The application finds that Phanginin A can reduce atopic dermatitis lesion scores, improve atopic dermatitis skin pathological thickening and inflammatory cell infiltration, reduce spleen inflammatory response, inhibit volume increase, promote thymus function recovery, down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the application also finds that Phanginin A can promote keratinocyte scratch healing, and can be used for repairing skin epidermal barrier damage.

The invention discloses a traditional Chinese medicine skin chemical stripping reagent and a preparation method thereof. The reagent comprises a saturated potassium hydroxide solution, glutinous rice, gallnut, glycerol and a centella asiatica extract which form a functional formula based on the compatibility principle of monarch, minister, assistant and guide. The preparation method comprises the steps of weighing, crushing, multi-stage stirring, filtering and cooling, closed packaging and the like, and is clear in process parameters and clear in operation path. The reagent is suitable for removing cuticles, the using method comprises dispensing, standing and flushing, the whole stripping process is mild, and the adaptability is high. Compared with traditional tartaric acid and salicylic acid exfoliating agents, the reagent is low in irritation, natural in structure and stable in formula, has the dual functions of exfoliating, repairing and conditioning, is suitable for improving various pigment increase type skin diseases, and has a good treatment effect on lesions located at the positions difficult to operate such as the nose, the lip periphery and the eye periphery. The technical scheme has good safety, ingredient controllability and popularization prospect, and is suitable for being used in the fields of orthopaedic surgery and dermatology department.

The application discloses an animal model and a detection method for evaluating the effects of a substance on hair growth and / or coloring. The evaluation steps are as follows: the experimental animal is plucked, and then the substance to be evaluated is injected into the tentacle pad or the mustache pad or the hair follicle cavity on one side of the experimental animal, and a control solution is injected into the tentacle pad or the mustache pad or the opposite symmetrical hair follicle cavity on the other side of the experimental animal; after a certain number of injections, the hair on the side injected with the control solution grows, while the hair on the side injected with the solution containing the substance to be evaluated grows or does not grow; the length and / or coloring of the grown hair are quantitatively detected and compared, so that the effects of the substance on hair growth and / or coloring can be accurately evaluated. The application utilizes the symmetry of the hair of the experimental animal, and a simple, direct and high-sensitivity method for quantitatively evaluating the effects of a substance on hair growth in vivo is obtained, which can be used for the research on skin diseases and the development of related drugs, cosmetics and the like, and has important scientific significance and application value.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

The application discloses a skin disease case retrieval method and device, a medium and a product, and relates to the technical field of medical image understanding and multi-modal knowledge fusion. The method encodes and maps multi-modal data of each skin disease case, obtains labeled features of the multi-modal data, projects the labeled features to a shared latent space, and obtains labeled features of the multi-modal data in the shared latent space; based on the labeled features, a Top-k node selection mechanism based on correlation scores is used to construct a single-modal knowledge graph of each image modality and a cross-modal knowledge graph between any two modalities, and then a modality-level representation and a cross-modal embedded representation are obtained, and a case database is obtained by splicing; the similarity between the feature vector of a skin disease query case and the feature vectors in the case database is determined, the feature vector with the highest similarity in the case database is output, and a retrieval result of the skin disease query case is obtained. The application can improve the accuracy and clinical applicability of cross-modal medical image retrieval.

The invention relates to the technical field of medical image processing, and particularly discloses a dermatosis auxiliary diagnosis method and system based on multi-mode optical image fusion, and the method comprises the steps: carrying out the semantic segmentation of an obtained dermatoscope image of a target skin region, and recognizing at least one target feature region; based on the semantic category and position information of the target feature region, screening out at least one associated feature region from an obtained RCM image set of a target skin region; extracting a first feature vector in the target feature region, and extracting a second feature vector in the associated feature region; and fusing the first feature vector and the second feature vector, and performing disease classification on the fused feature vector based on a trained classification model to obtain a skin disease classification result of the target skin area. According to the method, the corresponding associated region can be screened out from the RCM image set according to the semantic segmentation result of the dermatoscope, and the efficiency and reliability of multi-modal data integration are remarkably improved.

The utility model discloses a crane part welding device which comprises a mounting longitudinal rod, a middle transverse rod, a connecting transverse rod, a dust removal assembly and a welding assembly, the dust removal assembly comprises a dust remover and a negative pressure dust collection cover, and the welding assembly comprises a rotating stand column and a water cooling welding gun. One end of the middle transverse rod is fixedly connected with the middle of the surface of the mounting longitudinal rod, the end, away from the mounting longitudinal rod, of the middle transverse rod is fixedly connected with a rotary supporting base, and the bottom of the rotary stand column is fixedly connected with the top of the rotary supporting base; according to the dust removal device, the dust removal assembly is arranged, so that the smoke dust concentration in a welding operation area is effectively reduced, the operation environment is remarkably improved, a cleaner and healthier working space is provided for operators, and the working efficiency is improved. The morbidity of occupational diseases such as respiratory system diseases and skin diseases can be reduced.

This invention relates to a phototherapy device for skin diseases, comprising a base unit, several adjustment units, several mounting units, several phototherapy units, and several covering units. Its advantages include: the base unit provides a mounting foundation, allowing for placement in homes or community medical institutions, overcoming the location limitations of whole-body phototherapy devices that can only be used in specific hospital departments; the sliding cooperation between the adjustment units and the base unit enables the horizontal reciprocating movement of the mounting units, allowing adjustment of the phototherapy unit's position according to the patient's needs; and the detachable connection between the phototherapy units and the mounting units facilitates the replacement of phototherapy units of different sizes according to the area of ​​skin lesions. Patients can complete treatment independently at home without frequent trips to the hospital, reducing time costs and the burden of treatment cycles. It also avoids the embarrassment of full-body exposure in public places like hospitals, alleviating situations where patients interrupt treatment due to privacy concerns.

1. Name of the design product: smoking device (for skin disease laser treatment). 2. Use of the design product: to achieve efficient smoke exhaust, reduce noise in the working environment, and optimize the operating environment in skin disease laser treatment. 3. Design points of the design product: the combination of shape and pattern. 4. Picture or photo that best indicates the design points: front view.

This invention provides a skin condition detection method and system based on image recognition. The method includes acquiring a skin image to be analyzed and related textual metadata; inputting the preprocessed image into a trained skin lesion segmentation model and outputting the segmentation result of the lesion region; automatically extracting the size information and at least one morphological quantitative feature of the skin lesion based on the segmentation result, and integrating the size information and the morphological quantitative feature as supplementary features into the textual metadata to form enhanced metadata; assigning appropriate weights to the image features and the textual features based on the mutual information between the image features and the textual features, and dynamically weighting and concatenating them to form a fused feature vector; inputting the fused feature vector into a classifier and outputting the classification result of the skin condition, which significantly improves the model's ability to distinguish similar skin diseases, especially early malignant lesions, and improves the classification accuracy.

Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed.

The utility model provides equipment for treating private parts of patients with skin diseases with skin lesions, and solves the problems that existing equipment is unstable in fixation, poor in air permeability and insufficient in comfort level. The device comprises a breast support and a scrotum support, the breast support adopts a half-bowl-shaped hollow supporting part and is composed of an inner layer and an outer layer, air holes are arranged in a staggered mode, and the ventilation effect is ensured. Connecting buckles are arranged on the two sides of the supporting part and used for being connected with shoulder straps, the tightness of the shoulder straps is adjusted through sliding sleeves and sliding buckles, and equipment stability is guaranteed. The scrotum support is composed of bent wedge-shaped separation ribs, the front side is arc-shaped, the rear side is linear, and the scrotum support has good supporting and air permeability. The fixing belt is fixed through the waist buckle and the hook-and-loop fastener and can be flexibly adjusted. The breast support comprises a left supporting part and a right supporting part which are connected through a middle belt to achieve stable supporting. The device design has good adaptability, air permeability and comfort, and is suitable for long-term nursing of skin disease patients.

The present invention relates to the use of Cutibacterium strains, cultures of said strains, or combinations thereof for the prevention, amelioration, and / or treatment of inflammatory skin diseases. Compositions containing Cutibacterium strains, cultures of said strains, or combinations thereof do not exhibit cytotoxicity, suppress the proliferation of immune cells that induce skin inflammation, suppress immune responses, have antibacterial effects against acne-causing bacteria, and promote the regeneration of skin cells, thereby providing excellent effects in the prevention, amelioration, and / or treatment of inflammatory skin diseases.