59 results about "Pemphigus" patented technology

This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for both pemphigus vulgaris and pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody.

The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the concomitant removal of T-cells associated with autoimmune disorders.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine composition formula for preventing and treating allergic dermatitis. The traditional Chinese medicine composition formula comprises raw materials in parts by weight as follows: 10-20 parts of raw astragalus membranaceus, 10-20 parts of prepared tuber fleeceflower roots, 10-20 parts of officinal magnolia bark, 10-20 parts of fineleaf schizonepeta herbs, 10-20 parts of divaricate saposhnikovia roots, 10-20 parts of slough, 10-20 parts of common ducksmeat herbs, 10-20 parts of virgate wormwood herbs, 10-20 parts of belvedere fruits, 10-20 parts of densefruit pittany root-bark, 2-10 parts of golden thread, 3-10 parts of largetrifoliolious bugbane rhizomes and 2-10 parts of liquorice. The traditional Chinese medicine composition formula is reasonable, raw materials used in the formula have a wide source and are low in cost, the traditional Chinese medicine composition has a reliable curative effect and a mild drug property, does not have toxic or side effects, is convenient to take or carry after being prepared in the form of powder, capsules, decoction or pills according to the requirement of Chinese pharmacopoeia (2010), has a satisfactory curative effect in treatment of various allergic reaction skin diseases such as urticaria, neurodermatitis, pruritus cutanea, contact allergic dermatitis, pemphigus and the like and is popular with patients and doctors.

This invention describes a method of preventing and treating inflammatory skin diseases by topical application of aurin tricarboxylic acid and its derivatives. Such diseases are characterized by immune attack, especially involving aberrant complement activation. The diseases include, but are not limited to, androgenetic alopecia (baldness), seborrheic dermatitis / dandruff, allergic dermatitis, primary cicatricial alopecia, pemphigus, psoriasis, discoid lupus erythematosis and dermatitus herpetiformis.

The present invention provides isolated peptides relating to the autoimmune diseases pemphigus vulgaris and multiple sclerosis. The peptides relating to pemphigus vulgaris are self epitopes and those relating to multiple sclerosis are foreign antigens derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and / or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.

This invention describes a method of preventing and treating inflammatory skin diseases by topical application of aurin tricarboxylic acid and its derivatives. Such diseases are characterized by immune attack, especially involving aberrant complement activation. The diseases include, but are not limited to, androgenetic alopecia (baldness), seborrheic dermatitis / dandruff, allergic dermatitis, primary cicatricial alopecia, pemphigus, psoriasis, discoid lupus erythematosis, and dermatitus herpetiformis.

The present invention relates to a composition for use in the prevention of the rejection of skin tissue, comprising an effective amount of a peptide comprising an epitope of an antigen selected from the group of the polypeptides type XVII collagen, VII collagen, integrin alpha 6, integrin beta 4, chains of laminin, chains of laminin 322, type IV collagen, plectin, plakoglobin, bullous pemphigoid antigen 1, periplakin, envoplakin, desmoglein 1, desmoglein 3, a desmocollin and human bullous pemphigoid antigen 2 (hBPAG2) wherein said epitope induces immunological tolerance against its underlying polypeptide, and / or a nucleic acid for expressing a peptide comprising an epitope of said antigen as well as a gene therapy based on the composition, in the context of autoimmune blistering diseases, such as bullous pemphigoid or genetic skin diseases such as epidermolysisbullosa.

The invention relates to a derivative of alpha-amino phosphonic acid containing saccharide groups, a preparation method and the medical application thereof, in particular to a compound which is represented by formula I and can adjust the functions of the immune system, a stereoisomer thereof and application of medical composition containing the compound and the stereisomer in preventing or treating autoimmune diseases, such as chronic nephritis, multiple sclerosis, psoriasis, systemic lupus erythematosus, rheumatoid arthritis, insulin-dependent diabetes, chronic and toxic thyroiditis, myasthenia gravis, ankylosing spondylitis, pemphigus and the like as well as organ transplantation and allergic diseases and the like or application as tool medicine for studying diseases related to the function of the immune system and / or the functional disorder of the immune system.

The invention relates to blood poison eliminating capsules, which is prepared from the following raw materials: antelope horn, scorpio, centipede, unprepared rehmannia root, sinkiang arnebia root, glabrous greenbrier rhizome and talc powder. A preparation method of the blood poison eliminating capsules comprises the following steps of: smashing antelope horn, scorpio, centipede and a half of the glabrous greenbrier rhizome into fine powder and mixing uniformly for later use; decocting unprepared rehmannia root, sinkiang arnebia root and the remaining glabrous greenbrier rhizome respectively, extracting, combining decoction liquids, filtering and concentrating the filtrate into thick paste for later use; and mixing the thick paste with the fine powder, drying, smashing, mixing uniformly, adding the talc powder, mixing uniformly and filling into capsules. The blood poison eliminating capsules have a simple preparation process, low cost, high medicament bioavailability, high stability, remarkable curative effect and no remarkable toxic or side effect, are scientifically prepared from Chinese medicinal herbs serving as raw materials, and have the effects of cooling the blood and removing the toxic materials, are mainly used for treating blood poisons such as psoriasis, erythroderma, systemic lupus erythematosus, dermatomyositis and pemphigus at acute stages, severe dermatitis medicamentosa, and the like. A more convenient and quicker Chinese traditional treatment mode is provided for the clinical treatment of skin diseases.

The present invention provides, among other things, methods of treating pruritic or inflammatory skin diseases or disorders, or pruritus associated with a disease or disorder, with an anti-OSMRbeta antibody, including methods of treating pruritus, associated with atopic dermatitis, chronic kidney disease-associated pruritus, uremic pruritus or prurigo nodularis, chronic idiopathic pruritus, chronic idiopathic urticaria, chronic spontaneous urticaria, cutaneous amyloidosis, lichen simplex chronicus, plaque psoriasis, lichens planus, inflammatory ichthyosis, mastocytosis and bullous pemphigoid,comprising a step of administering to a subject in need of treatment an anti-OSMRbeta antibody at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce one or more symptoms of the disease or disorder relative to a control.

The present invention concerns developing a remedy for treating pemphigus by administering a CD40L antagonist to patients with pemphigus such as pemphigus vulgaris or pemphigus foliaceus, and a preventive agent for preventing the development of pemphigus by preventively administering a CD40L antagonist. Antagonists such as an anti-CD40L antibody that inhibit the interaction between a CD40L mediating the contact-dependent helper effector function on the T cell surface and a CD40 receptor on the antigen-presenting cell surface, were effective as a remedy and a preventive agent for pemphigus.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine composition formula for preventing and treating allergic dermatitis. The traditional Chinese medicine composition formula comprises raw materials in parts by weight as follows: 10-20 parts of raw astragalus membranaceus, 10-20 parts of prepared tuber fleeceflower roots, 10-20 parts of officinal magnolia bark, 10-20 parts of fineleaf schizonepeta herbs, 10-20 parts of divaricate saposhnikovia roots, 10-20 parts of slough, 10-20 parts of common ducksmeat herbs, 10-20 parts of virgate wormwood herbs, 10-20 parts of belvedere fruits, 10-20 parts of densefruit pittany root-bark, 2-10 parts of golden thread, 3-10 parts of largetrifoliolious bugbane rhizomes and 2-10 parts of liquorice. The traditional Chinese medicine composition formula is reasonable, raw materials used in the formula have a wide source and are low in cost, the traditional Chinese medicine composition has a reliable curative effect and a mild drug property, does not have toxic or side effects, is convenient to take or carry after being prepared in the form of powder, capsules, decoction or pills according to the requirement of Chinese pharmacopoeia (2010), has a satisfactory curative effect in treatment of various allergic reaction skin diseases such as urticaria, neurodermatitis, pruritus cutanea, contact allergic dermatitis, pemphigus and the like and is popular with patients and doctors.

The invention discloses an ELISA (enzyme-linked immuno sorbent assay) kit for detecting a human BP180 IgG (immunoglobulin G) antibody and application of the ELISA kit. The kit contains a BP180 microporous band, and the BP180 microporous band is respectively coated with polypeptides as shown in SEQ ID NO. 1-29 or a mixture of the polypeptides as shown in SEQ ID NO. 1-29. Preferably, the kit also contains standard serum 1 and 2, an enzyme-labeled antibody, a diluent, a reaction buffer solution, a cleaning buffer solution, an enzyme matrix solution and a stop solution. According to the invention, a plurality of antigen polypeptides are used for replacing a long-fragment complete protein as a coating protein of ELISA, so that a large amount of cost is saved while antigen epitopes recognized by an antibody are fully guaranteed, and compared with NC16a recombinant protein, the sensitivity is higher. According to the invention, the human BP180 IgG antibody is detected by using an ELISA method, and compared with an existing immunoblotting method, the ELISA method is easier to be applied to clinical diagnosis of bullous pemphigus and BP180 type mucous membrane pemphigus.