58 results about "Vitiligo" patented technology

The invention discloses observation of the curative effect of AKBA gel combined with narrow-spectrum UVB irradiation in treatment of leucoderma. The invention creatively discovers that the combined use of AKBA and phototherapy has a remarkable and better treatment effect on leucoderma for the first time, provides an effective drug combination strategy for treatment of leucoderma, and has a good clinical application prospect and important conversion significance in the technical field of research and development of leucoderma treatment drugs.

The invention discloses application of an ATP (adenosine triphosphate) citrate lyase (ACLY) inhibitor in preparation of a medicine for treating leucoderma, and belongs to the technical field of preparation of medicines for treating leucoderma. Through targeted inhibition of ACLY activity or specific knockout of ACLY in CD8 + T cells, abnormal activation of ACLY and secretion of killing effector molecules (Granzyme B, IFN-gamma, Perforin and the like) are inhibited, and infiltration of the CD8 + T cells to skin lesion parts is reduced, so that melanocytes are protected from immune injury, and the progress of vitiligo is blocked. The application is based on the abnormally high expression of ACLY in CD8 + T cells of vitiligo patients and the close association with disease activity, and a brand new targeted treatment thought and a medicine research and development direction are provided for vitiligo.

1. Name of the product in this design: Ultraviolet Phototherapy Device (308 nm). 2. Intended use of this design: Treatment of psoriasis and vitiligo. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a traditional Chinese medicine for treating leucoderma and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. Comprising medicine for oral administration, astragalus membranaceus, codonopsis pilosula, bighead atractylodes rhizome, rhizoma smilacis glabrae, Chinese yam, fructus psoraleae, angelica sinensis, buffalo horn shreds, dogwood, salvia miltiorrhiza, red paeony root, safflower carthamus, ligusticum wallichii, peach kernel, polygonum multiflorum, eclipta alba, white mulberry root-bark, divaricate saposhnikovia root, radix bupleuri, scutellaria baicalensis, curcuma aromatica, fingered citron, rhizoma cyperi, felwort, parched white peony root, tribulus terrestris, gardenia, radix angelicae and rhizoma typhonii. The external immersion liquid comprises fructus psoraleae, radix angelicae, cortex dictamni, radix polygoni multiflori, borax, rhizoma typhonii, semen cuscutae, flos carthami and white spirit. Through oral administration for regulating qi and blood, tonifying liver and kidney, dredging meridians and collaterals and consolidating root, external application for dredging local parts and promoting pigment, internal and external synergism and simultaneous treatment of both symptoms and root causes, the traditional Chinese medicine is especially suitable for middle-aged and elderly patients with qi and blood deficiency, deficiency of liver and kidney and qi stagnation and blood stasis type leucoderma.

This specification discloses FABP inhibitor compounds and their use in pharmaceutical compositions for treating diseases that highly express any of these FABPs, including cancers, particularly triple-negative breast cancer (TNBC), and other pro-inflammatory diseases, including cardiovascular diseases, obesity or obesity-related disorders, diabetes, dyslipidemia, impaired glucose tolerance or impaired fasting blood glucose, vitiligo, psoriasis, autoimmune disorders, pain, and dementia. This specification also discloses methods for preparing the disclosed compounds.

The application discloses a chitosan-glycine-copper chelate and a preparation method and application thereof in treating leukoplakia and vitiligo. In the preparation, chitosan is first placed in an acid aqueous phase system, and is fully dissolved and forms a uniform transparent or translucent solution under stirring; then glycine is added, and the chitosan and the glycine are fully mixed under stirring to build an organic ligand environment containing multiple coordination groups; subsequently, a copper source is introduced to perform a chemical reaction, and finally the chitosan-glycine-copper chelate is obtained. The chitosan-glycine-copper chelate shows a strong promoting activity completely different from all other substances (including simple mixtures of components thereof), the chelate can continuously and significantly activate tyrosinase activity, and promote the formation of melanin, so that the purpose of treating leukoplakia and vitiligo is achieved.

The application discloses a compound morinda officinalis color-increasing liniment for treating vitiligo and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, wherein the liniment is prepared from morinda officinalis, spilanthes acmella, giant knotweed, caesalpinia sappan, psoralea corylifolia, radix angelicae dahuricae and rhizoma smilacis glabrae as raw medicinal materials. The preparation method comprises the following steps: dynamic reflux extraction, percolation extraction, macroporous adsorption resin purification and preparation molding. Through the classification extraction and purification process, the photosensitive active ingredients are retained, and the photo-toxic impurities are effectively removed, so that the photo-toxicity is completely negative. The pharmacodynamic test shows that the liniment has a significant curative effect on vitiligo. The safety test shows that the liniment has no skin irritation and no allergenicity, and has excellent light safety. The quality research shows that the quality of the liniment is stable and controllable. The liniment has definite curative effect, high safety and stable quality, and has a good clinical application prospect.

The application discloses a mouse vitiligo induction model based on chronic stress factors, wherein different kinds of stress factors capable of triggering stress response of animals are applied to stimulate the mouse periodically within a certain time period, so as to prevent the mouse from producing habitual response to the stress source and to promote the mouse to become white and the tail epidermis to be flaky. The technical method is different from the existing vitiligo model method, is based on the mechanism of occurrence and development of vitiligo observed in the clinic, and promotes the mouse to truly develop the vitiligo phenomenon from the whole instead of simulating the disease evolution locally. Compared with the existing vitiligo promoting mechanism, the effect is more stable and the authenticity is higher. The technical method is based on the objective fact that the clinical vitiligo patients often combine anxiety and depression to design the stress factors, and considers that the stress factors and the occurrence and development of vitiligo may be inter-caused and viciously circulate, namely, the adverse life events as the stress factors cause the damage and dysfunction of the melanin synthesis system at the micro level and form the vitiligo change at the macro level.

The invention discloses a method for determining chemical components in a medicine for treating vitiligo, which relates to the technical field of medicine analysis, and is characterized in that ultra-high performance liquid chromatography-mass spectrometry is adopted to determine the content of chemical components in a Bailing tablet: psoralen, isopsoralen, astragaloside, quercetin, polysaccharide and amino acid. The determination method comprises the following steps: respectively injecting a reference solution and a test solution into a liquid chromatograph for determination to obtain a chromatogram, and calculating the content of paeoniflorin in a test sample by adopting an external standard method, chromatographic conditions of a chromatogram obtained by adopting a liquid chromatograph are as follows: octadecylsilane chemically bonded silica is taken as a filling agent. According to the method for determining the chemical components in the medicine for treating leucoderma, the established detection method is verified, and the result shows that the detection method is easy and convenient to operate, accurate in result, high in specificity and good in reproducibility.

1. Name of the product subject to this design: Laser Therapy Device (EXC-5001). 2. Purpose of this design: For use by medical institutions as an adjunct treatment for psoriasis and vitiligo. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of the design product: excimer light therapy instrument (308nm). 2. The use of the design product: for the treatment of vitiligo. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The utility model discloses a vitiligo treatment medicine smearing device which comprises a medicine bottle, an installation sleeve is arranged at the bottom end of the medicine bottle, a sealing mechanism is arranged in the installation sleeve, the sealing mechanism comprises a sealing sleeve, a sealing ring, a movable plate, a fixed sleeve and a limiting sleeve, the sealing sleeve is installed in the installation sleeve, the sealing ring is installed on the inner wall of the installation sleeve, and the movable plate is installed on the inner wall of the movable plate. The movable plate is attached to the top face of the sealing sleeve, the fixing sleeve is installed on the inner wall of the installation sleeve, the limiting sleeve is installed on the inner wall of the fixing sleeve, a medicine discharging mechanism is arranged on the movable plate, the sealing sleeve and a sealing ring are arranged in the installation sleeve to form a double-sealing structure of the sealing mechanism, and the movable plate and the sealing sleeve are tightly attached to be matched with multiple sets of sealing strips. Meanwhile, due to the combined design of a fixing sleeve and a limiting sleeve, the movement stability of the movable plate is guaranteed, the movable plate is prevented from shifting through the guiding effect of a limiting rod, the problem that in the prior art, sealing performance is insufficient is solved, and liquid medicine leakage and pollution are effectively avoided.

The present disclosure provides methods and compositions for treating a disease or condition involving inflammation in the skin, e.g., atopic dermatitis, eczema other than atopic dermatitis, hidradenitis suppurativa, vitiligo, alopecia areata, scleroderma (including systemic sclerosis), dermatomyositis, epidermolysis bullosa, mastocytosis, keloids, acne, rosacea, or bullous pemphigoid, with a therapeutic dose of an anti-TNF-like ligand 1A (TL1A) antibody (Afimkibart).

The application provides a composition containing salicin, a product and application thereof, and relates to the technical field of cosmetics. Specifically, the application provides application of salicin in promoting intracellular melanin synthesis, and it is first proved that salicin can promote intracellular melanin synthesis by promoting tyrosinase activity, thereby providing a new functional ingredient for enhancing intracellular melanin synthesis, and preparing a product for improving and treating white hair and vitiligo.

The invention relates to the technical field of skin detection equipment, and discloses an intelligent vitiligo detection device which comprises an intelligent detection and treatment equipment body, image acquisition equipment arranged on the intelligent detection and treatment equipment body and a hand placing and folding mechanism. The image acquisition equipment is fixed through a multi-angle adjusting frame, the angle can be flexibly adjusted to be attached to the skin, and uniform irradiation of ultraviolet light is guaranteed. The hand placing and folding mechanism comprises a lower folding plate which can be unfolded, through linkage of a telescopic rod and a spring, the device can adapt to hands of different sizes, and the universality of detection is improved. And the mechanism can also realize quick folding and storage towards the bottom of the equipment integrally through the matching of the positioning rod and the spring, and is compact in structure and convenient to store. The device further comprises an image processing system which can automatically segment a white spot area in the image, accurately calculate the area and the relative gray value of the white spot area and generate a quantitative analysis report. Through combination of structural innovation and intelligent analysis, accurate, objective and convenient detection of vitiligo conditions is realized.

The invention provides new application of an ATOX1 gene and ATOX1 protein, and belongs to the technical field of treatment of vitiligo diseases. The ATOX1 gene serving as a key gene of copper metabolism is disclosed for the first time, and melanin synthesis is promoted by activating the melanocyte copper metabolism process, so that the effect of resisting leucoderma is achieved. The ATOX1 gene and / or the ATOX1 protein can be used as a key biomarker in the vitiligo morbidity process, and a new target and a new molecular basis are provided for vitiligo research.

This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

The utility model belongs to the technical field of vitiligo treatment, particularly relates to a phototherapy device for vitiligo treatment, and aims to solve the problem that in the prior art, when the phototherapy device is used traditionally, a light source is prone to irradiating the same position all the time, so that the use effect is affected, the following scheme is provided: the phototherapy device comprises a base, and a treatment table and a shading cover which are respectively arranged at the top of the base; the collecting box is fixedly mounted on one side of the treatment table; the sponge layer is fixedly mounted at the top of the treatment table; the display screen is fixedly mounted on the other side of the treatment table; the fixing mechanism is arranged at the top of the base and used for fixing a patient; the illuminating lamp adjusting mechanism is arranged at the top of the treatment table and used for adjusting the treatment position of the patient; the shading mechanism is arranged at the top of the base, the fixing mechanism comprises two supporting plates fixedly installed on one side of the shading cover, when the LED lamp is traditionally used, a light source can irradiate different positions, and the using effect is improved.

The invention discloses a method for analyzing the effect of active pharmaceutical ingredients between T cells and melanocytes in vitiligo. The method comprises the following steps: obtaining transcriptome data; performing differential gene analysis on the transcriptome data to obtain an analysis result; identifying a first gene associated with a disease; determining a second gene by using a machine learning algorithm; drawing a spatial distribution mode of a second gene in the leucoderma skin; carrying out molecular docking on the HSPA1A protein receptor and a small molecule drug ligand, and simulating and predicting a bioactive component for regulating a second gene in the drug; and evaluating the regulation effect of the bioactive components of the drug on the second gene expression pattern, endoplasmic reticulum stress and CD8 + T lymphocyte infiltration by using the animal model, and analyzing the effect of the active components of the drug between T cells and melanocytes. The method provided by the invention can be used for evaluating the effect of the active pharmaceutical ingredient in vitiligo treatment, and particularly determining the effect of the active pharmaceutical ingredient between T cells and melanin cells in vitiligo.

The invention relates to the technical field of medical instruments, in particular to a vitiligo precise treatment system based on image recognition. Comprising an image acquisition module, a real-time analysis module, a treatment planning module and an operation guiding module. And the image acquisition module is used for acquiring contrast image information of the skin area of the patient irradiated by the 308 emitting head and the wood lamp in real time. According to the invention, through the closed-loop design of image acquisition, analysis, planning and guidance, intelligent accurate control and visual guidance are provided for manual operation, so that the problems of laser divergence, energy attenuation, out-of-control dosage and high calculation power cost of non-contact irradiation are avoided; the device has the advantages that the device is simple in structure and convenient to use, the defects that a traditional contact pressing mode depends on medical care experience, operation is tired and accuracy is insufficient are overcome, the accuracy of manual control over an irradiation path by medical staff is greatly improved, the problems of repeated irradiation, missing irradiation and the like are solved, the physical load and cognitive pressure of the medical staff are remarkably relieved, and treatment accuracy, safety and operation efficiency are improved.

The application belongs to the technical field of cell induction differentiation culture and cell culture medium preparation, and particularly relates to a cell culture medium and application thereof in inducing olfactory mucosa mesenchymal stromal cells to differentiate into melanocytes. The culture medium has clear components, and the components used are mature commercial components, which are convenient and easy to obtain. The olfactory mucosa mesenchymal stromal cells are induced to become melanocytes expressing tyrosinase and containing melanin granules, which has the advantages of simple induction method and autologous induction avoiding ethical problems. The olfactory mucosa mesenchymal stromal cells are separated from nasal mucosa tissue, the nasal mucosa tissue is convenient to obtain, the nasal cavity part has rich blood supply, the wound is small and heals rapidly, and the human body is not continuously damaged. The prepared melanocytes can be used as seed cells for treating vitiligo disease, and have wide prospects.

The present application relates to the field of biological medicine, and more particularly to a nano-composite system for treating vitiligo, an intelligent controlled-release microneedle patch and a preparation method thereof, wherein the nano-composite system contains enzyme-responsive micelles and polyethylene glycol modified polydopamine nanoparticles; the enzyme-responsive micelles are formed by glyceryl monostearate encapsulating ginseng root-derived exosomes; and the polyethylene glycol modified polydopamine nanoparticles are formed by covalent connection of a polydopamine core and methoxy-polyethylene glycol-amine. Compared with the prior art, the nano-composite system of the present application can realize the spatiotemporal programmed release of drugs in response to the pathological microenvironment, wherein the polydopamine nanoparticles provide instant antioxidant effect, and the exosome micelles trigger release under the condition of overexpression of matrix metalloproteinase-9, thereby synergistically exerting anti-inflammatory and promoting pigment regeneration effects; animal experiments have proved that the patch can effectively reverse the white spots and realize the recoloring of hair and skin. The microneedle patch thus prepared can realize transdermal self-administration, is convenient and painless.

The embodiment of the application discloses a kind of vitiligo auxiliary diagnosis methods, devices and storage medium of multi-modal medical image collaborative segmentation and classification, wherein the method comprises: obtaining the multi-modal image pair of the clinical image and Wood lamp image of the same examinee;According to the imaging characteristics of two kinds of modalities, the image pair is preprocessed and modality-specific data enhancement;The multi-modal image pair after processing is input into the feature extraction network to obtain each modality feature, and spatial guidance information for subsequent segmentation is generated;Each modality feature is input into vector quantization fusion module for cross-modal feature fusion to obtain semantic consistent fusion feature;Based on the fusion feature, a segmentation branch and a classification branch are constructed to realize the joint output of lesion region segmentation and disease activity classification, and the collaborative effect of the two tasks is improved through inter-task interaction. By using the present application, end-to-end joint optimization of vitiligo lesion segmentation and disease activity classification can be realized, and the diagnostic performance is improved.

Disclosed herein are FABP inhibitor compounds and their use in pharmaceutical compositions for the treatment of diseases, including cancers that highly express any of FABP, particularly triple negative breast cancer (TNBC), and other inflammation-inducing diseases, including cancer that highly express any of FABP. Comprise cardiovascular diseases, obesity or obesity-related diseases, diabetes, dyslipidemia, impaired blood glucose tolerance or impaired fasting blood glucose, vitiligo, psoriasis, autoimmune diseases, pain and dementia. Also disclosed herein are methods for preparing the disclosed compounds.

The present invention provides methods for treating vitiligo using antibodies which specifically bind to IFN-γ.

The instant disclosure relates to the use of an anti-CXCL-10 antibody for the treatment of vitiligo. Also provided are specific doses and administration protocols as well as criteria for patient selection and endpoints of efficacy of these methods of treatment.

The invention relates to an application of a pyrrolopyrimidine compound and a composition of the pyrrolopyrimidine compound. The invention relates to application of a compound as shown in a formula I and pharmaceutically acceptable salt or pharmaceutical composition thereof in preparation of drugs for treating and / or preventing autoimmune skin diseases. The traditional Chinese medicine composition can effectively treat and / or prevent autoimmune skin diseases, especially atopic dermatitis, leucoderma and alopecia areata.

The invention relates to application of Ro5-4864 or pharmaceutically acceptable salt in preparation of a medicine for treating and / or preventing melanocyte degeneration diseases caused by inflammatory immune response induced by oxidative stress. The melanocyte degeneration diseases caused by inflammatory immune response induced by oxidative stress comprise vitiligo, leukoplakia and pityriasis albicans. The Ro5-4864 and the pharmaceutically acceptable salt of the Ro5-4864, disclosed by the invention, inhibit continuous loss of melanocytes from oxidative stress, are strong in targeting effect and relatively small in side effect, and have remarkable advantages and progress compared with existing medicines.

The invention relates to the technical field of medical instruments, and discloses a vitiligo systemic examination device for the dermatology department and a using method, the vitiligo systemic examination device comprises a cabin body, a rotating base and N detection assemblies, each detection assembly comprises a light source module and a plurality of image acquisition units, and the light source module is used for emitting exciting light with a preset wavelength towards the body surface of an examined object; the image acquisition unit acquires body surface image information of a detected object. According to the design, the rotating base drives the detected object to rotate around the vertical axis, the light source module can sequentially irradiate all directions of the body surface of the detected object, the image acquisition unit synchronously acquires body surface images at different angles, and therefore all-directional and continuous data acquisition of the body surface of the detected object is achieved; multi-angle and multi-band image data of the whole body can be obtained in one rotation period, so that the single inspection time is shortened, and region omission caused by manual operation is avoided.