648 results about "Vitiligo" patented technology

Skin disorders such as, for example, atopic dermatitis, dyshidrosis, eczema, lichen planus, psoriasis, and vitiligo, are treated by applying high doses of ultraviolet light to diseased regions of a patients skin. The dosage employed exceeds 1 MED, an MED being determined for the particular patient being treated, and may range from about 1 MED to about 20 MED or higher. The ultraviolet light has a wavelength within the range of between about 295 nanometers to about 320 nanometers and preferably is between about 300 nanometers and about 310 nanometers. High doses of ultraviolet light are restricted to diseased tissue areas so as to avoid risk of detrimental side affects in healthy skin, which is more susceptible to damage from UV light. Cooling the skin prior to and/or while exposing the skin to the UV light can be used to minimize tissue damage resulting from exposure to the UV light. Higher doses of UV light can therefore be employed without injurious affects.

Skin disorders such as, for example, atopic dermatitis, dyshidrosis, eczema, lichen planus, psoriasis, and vitiligo, are treated by applying high doses of ultraviolet light to diseased regions of a patients skin. The dosage employed exceeds 1 MED, an MED being determined for the particular patient being treated, and may range from about 1 MED to about 20 MED or higher. The ultraviolet light has a wavelength within the range of between about 295 nanometers to about 320 nanometers and preferably is between about 300 nanometers and about 310 nanometers. High doses of ultraviolet light are preferably restricted to diseased tissue areas so as to avoid risk of detrimental side affects in healthy skin, which is more susceptible to damage from UV light. Cooling the skin prior to and/or while exposing the skin to the UV light can be used to reduce tissue damage resulting from exposure to the UV light. Higher doses of UV light can therefore be employed without injurious affects. A specialized handpiece provides a beam profile especially suitable for application of controlled doses. A specialized delivery device is useful for UV treatment of tissue within the mouth.

The present invention relates to the use of one or more tripeptides selected from the group consisting of ^NLys-Pro-Val^C, ^NLys-Pro-Thr^C and ^NpGLu-His-Pro^C for the reduction of oxidative stress. The above tripeptides are particularly useful for the treatment of a disease or damage caused by oxidative stress; such as vitiligo, scleroderma, necrosis, or erythema; furthermore, a disease or damage of the hair, like premature hair loss or premature formation of grey hair. Furthermore the invention relates the cosmetic use of the above tripeptides, in particular against skin aging. Further the invention relates cosmetic compositions containing at least one of said tripeptides.

The invention relates to a gel composition containing tacrolimus, which contains the tacrolimus and ingredients of a matrix, wherein, the ingredients of the matrix contain one or more of liquid polyethylene glycol, glycerin and propylene glycol, the content of the tacrolimus in the gel is 0.01 percent to 0.5 percent, and the weight ratio of the tacrolimus to one or more of the liquid polyethylene glycol, the glycerin and the propylene glycol is 1: (50 to 3000). The invention further relates to a preparation method of the gel composition of the tacrolimus and the application of the gel composition in the preparation of drugs for the treatment of atopic dermatitis, vitiligo, psoriasis, hormone-dependent dermatitis, intractable neurodermatitis, lupus erythematosus, alopecia areata and other diseases.

A method of stimulating melanogenesis in a skin surface of a patient, by treating the skin surface with a topical formulation comprising an effective amount of 17-phenyl-18,19,20-trinor-PGF2α ethyl amide in a dermatologically acceptable carrier. The topical formulation may be a cream, a gel, a lotion, a spray, an ointment, an aqueous solution, a nonaqueous solution, or a transdermal patch. The dermatologically acceptable carrier may contain an oily carrier or an aqueous carrier.

Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.

A non-natural HSP70 activating region that activates dendritic cells. Polypeptides that bind to the HSP70 activating region can be used to treat autoimmune diseases, such as vitiligo, by binding to HSP70 and preventing HSP70 form activating dendritic cells. The HSP70 binders can be constructed in the form of fusions proteins with a trimerizing structural element that may associate to form a trimeric complex. Pharmaceutical compositions and methods for treating vitiligo using the HSP70 binding proteins, fusion proteins and complexes.

Sets of genes are identified that show modulated activity in hyperpigmented sun-exposed (HE) and non-hyperpigmented sun-exposed (NHE) skin, when compared to non-hyperpigmented non-exposed (NHNE) skin. The modulated sets of genes reveal important information about the genetic changes that take place in skin as a result of environmental exposure and damage. The modulated sets of genes may be used to fabricate custom DNA microarrays for evaluating patients with skin diseases or disorders. The microarrays may also be used to screen new substances for treating skin diseases and disorders. The modulated gene sets, and substances that target them, may also be used to develop therapies for individuals who suffer from hypopigmentation, such as those with Fitzpatrick type I skin or vitiligo.

This invention relates to an external use medicine for treating skin pigment reduction and its preparing method. This external use medicine is prepared by using alcohol, radices polygoni multiflori, fructus psoraleae, flos sophorae immaturus, dioxyacetonem through refining. The medicine has the strongpoint of fast effectiveness, high curative effect, innocuity, no side-effect, convenience in use and low price, especially suitable for treatment of vitiligo.

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a base anti-inflammatory agent, such as indometacin; one or more optional active ingredients selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol™, L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF-α) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

The invention discloses a leucoderma covering agent. The leucoderma covering agent is a covering liquid or covering cream, wherein the covering liquid mainly comprises 1,2-propyleneglycol, jojoba oil, a preservative, a surfactant, vitamin E acetate, 1,3-dihydroxyacetone, an edible pigment and deionized water; and the covering cream mainly comprises magnesium aluminum silicate, 1,2-propyleneglycol, methyl parahydroxybenzoats, propyl p-hydroxybenzoate, imidazolidinyl urea, talcpowder, titanium dioxide, iron oxide, jojoba oil, vegetable fat, vitamin E acetate, stearyl alcohol, stearic acid, decapolyglycerol monooleate, diolein, triethanolamine and deionized water. The covering liquid has waterproof, sweatproof and wear-resistant effects, and is durable; the covering cream is quick in coloration and natural in color formation, and is convenient to use; and the covering liquid and the covering cream are combined to provide comprehensive covering for leucoderma patients.

Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength range. Uses may include the treatment of such conditions as psoriasis, vitiligo, pruritus, acne, vitamin-D deficiency and atopic dermatitis. Topical creams, sprays, or other compositions may be used, with or without dosimeters, or in conjunction with an application, which calculates local UV exposure and other factors relating to dosage.

The invention discloses a tissue engineering material-based culture method and applications of melanophore. In the method of the invention, the tissue engineering technology is used to build carrier material with good biocompatibility and perform culture (co-culture) and transfer of melanophore or melanophore, fibroblast and keratinocyte and the method can be used in depigmentation diseases such as vitiligo and for the regulation of skin color. The invention relates to the preparation of the carrier material with biocompatibility and the building and transplanting of the cell-carrier composite material. The carrier material can be used to provide good carrier for cell culture, maintain cellular activity and solve the problem that the cell suspension is easy to lose in the cellular transplantation process; the inoculum density and culture time of cells can be regulated at the same time, the regulation to the skin colors of different individuals can be realized; and the carrier materialhas good performances such as damage resistance, tear resistance and easy transfer, has good function of promoting wound healing, and satisfies the use requirements of the large-area depigmentation disease and the regulation of skin color.

The invention discloses a novel application of 20(R)-ginsenoside Rg3 in preparation of medicines for relieving or/and treating leucoderma. Tests show that the 20(R)-ginsenoside Rg3 is significant in treating effects for the leucoderma, quick in effectiveness, low in toxic and side effects, safe, efficient, stable, simple in preparation process, suitable for industrial production, and prone to popularization. The application provides a novel medicine source for preventing and treating the leucoderma and complications thereof.

The invention provides a new route of administration for sirolimus, namely that sirolimus is prepared into an external preparation for treating skin diseases. The external preparation is a prescribed preparation or compound preparation containing sirolimus, and the dosage form can be any one of pharmaceutical skin external dosage forms including cream, ointment, gel, spray, coating agent and the like, and can be any one of new external dosage forms including solid lipid nanoparticles and the like. The research shows that the external preparation containing sirolimus can be used for treating multiple immune and inflammatory skin diseases including atopic dermatitis, eczema, dermatitis, lichen planus, psoriasis, vitiligo, rosacea, sarcoidosis and the like, and is good in curative effect, high in safety and free of skin irritation. The external preparation is expected to become an important pharmaceutical preparation for clinically treating skin diseases following corticosteroids.

The invention discloses a drug for treating leucoderma and a preparation method thereof. The drug is prepared from gecko, human placenta, fructus psoraleae, prepared rehmannia root, pulp of cornus officinalis, dendrobium, radix astragali, pilose antler, fleece-flower root, glossy privet fruit, donkey-hide gelatin, tortoise-plastron glue, semen cuscutae, rhizoma polygonati, root of Angelicasinensis (Oliv)Diels, semen astragali complanati, raspberry, wolfberry, red ginseng, pseudo-ginseng, ganoderma atrum, radix salviae miltiorrhizae, stigma croci, long-nosed pit viper, tribulus terrestris, ligusticum wallichii, dahurian angelica root, divaricate saposhnikovia root, balloonflower root, tree peony bark, tuber fleeceflower stem, trogopterus dung, white-stiff silkworm, fruit of Chinese magnoliavine, katsumadai seed, medicated leaven, chicken's gizzard membrane, radish seed, bighead atractylodes rhizome, poria cocos, fructus amomi, herba siegesbeckiae, coix seed, black bean hull, esliptae herba, duckweed, motherwort, lithospermum, common clubmoss herb, periostracum serpentis, periostracum cicada, tamarix chinensis, native copper, Chinese-date, dried orange peel and madder. The drug does not damage the human body, realizes treatment on both symptoms and root causes and thoroughly cures leucoderma.

The invention relates to traditional Chinese medicine for treating leucoderma, which is characterized in that eclipta alba, angelica root, angelica, polygonum multiflorum, astragalus campanulatus R.Brown, ligusticum, tribulus terrestris, ligustrum lucidum, nepeta, lithospermum, paris polyphylla, divaricate saposhnikovia root, saffron crocus, purple salvia miltiorrhiza, radix sophorae flavescentis and fructus psoraleae are prepared into various oral preparations according to the conventional pharmacy method. The traditional Chinese medicine has the advantages that the functions of warming and nourishing the liver and the kidney, dispelling the wind, eliminating dampness, regulating qi and blood, clearing and activating the channels and collaterals, activating blood, dissolving stasis and regulating the immunity are realized, the effect of improving the skin micro circulation is reached, the curative effect on the prevention and the treatment of the leucoderma is definite, and the taking is convenient.

Compositions and methods are disclosed for treating hypomelanotic conditions such as vitiligo and promoting melanogenesis.

The invention discloses a photoelectric device for vitiligo treatment. Low-price deep ultraviolet LED light sources are adopted; beam combination and light intensity graded adjustment of ultraviolet light are realized through photoelectric devices; a computer vision technology is utilized to realize intelligent detection on a plurality of main parameters of affected skin; feedback control on the deep ultraviolet LED light sources, galvanometers and a liquid lens can be completed; and therefore, the cost of the vitiligo treatment equipment is greatly decreased, and the intelligent degree of the vitiligo treatment equipment is improved, and the work intensity of doctors can be reduced.

The present invention relates to a system and method for the photomodulation of living tissue. When photomodulated, living tissue will exhibit bioactivation or bioinhibition according to the present invention and, when using the disclosed sources of narrowband multichromatic radiation can cause significant dermatologic advantages such as hair removal, hair growth stimulation, wrinkle reduction, acne reduction and scar removal, vitiligo, etc. The present invention has application to non-dermatological medical treatments including tumor growth inhibition, cell regeneration, the stimulation of tissue in organs, etc.

The invention relates to a medicine for external use for treating skin diseases, and in particular relates to a medicine for external use for treating psoriasis, leucoderma, fungus infection and bromhidrosis, aiming at making up the defects of the existing medicine for external use for treating psoriasis, leucoderma, fungus infection and bromhidrosis; the medicine for external use comprises silver element and a pharmaceutically acceptable carrier, wherein the content of the silver element is 0.000001-0.005g/ml; and the silver element is one in nano-silver, silver salt, salt solution of silver or complexing silver, or mixture formed by mixing several in nano-silver, silver salt, salt solution of silver and complexing silver according to any proportion. By a plurality of years of clinical experience, the study for the drug properties and the observation for the treatment effect of the medicine of the inventor, the components and the ratio of the medicine are adjusted for a plurality of times, and the formulation of the medicine for external use is finally confirmed; the medicine for external use effectively reduces the medication time of a patient, thus reducing the treatment cost; and the medicine for external use is ideal is treatment effect, higher in cure rate and lower in recurrence rate, thus having important clinical significance as well as higher social value and marketable value.