The application provides a multi-layer penetration controlled-release acid preparation and a preparation method thereof, and belongs to the field of
cosmetics. The preparation is composed of
Aspergillus oryzae
fermentation substrate freeze-dried
powder, composite alpha-hydroxy acid,
salicylic acid,
poloxamer 407, polyhydric
alcohol and non-ionic surfactant. The freeze-dried
powder is obtained by co-fermenting olea europaea leaves and
curcuma and refining through
ultrafiltration. A temperature-sensitive
phase change system is constructed by using
poloxamer, so that the product is changed from a
liquid state to a
gel state at body temperature, and the synergistic
controlled release of acid components and bioactive substances is realized. The preparation process adopts low-temperature swelling and vacuum freeze-
drying technology, so that the stability of the
system and the efficiency of the active substances are ensured. The application significantly reduces the
irritation of high-concentration acid, improves the black suppression and repair effect, and is suitable for precise improvement of
hyperpigmentation problems such as chloasma.