553 results about "Hyperpigmentation" patented technology

The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).

The evolution of a skin condition over time can be useful in its assessment. In an illustrative arrangement, a user captures skin images at different times, using a smartphone. The images are co-registered, color-corrected, and presented to the user (or a clinician) for review, e.g., in a temporal sequence, or as one image presented as a ghosted overlay atop another. Image registration can employ nevi, hair follicles, wrinkles, pores, and pigmented regions as keypoints. With some imaging spectra, keypoints from below the outermost layer of skin can be used. Hair may be removed for image registration, and restored for image review. Transformations in addition to rotation and affine transforms can be employed. Diagnostic correlations with reference image sequences can be made, employing machine learning in some instances. A great variety of other features and arrangements are also detailed.

The invention features methods, kits, and compositions for treating aging-related skin conditions (e.g., wrinkles), pigmentation disorders, acne, and scar formation, as well as methods, kits, and compositions for preventing scar formation.

The invention provides unique and novel strains of microalgae that have been subjected to non-transgenic methods of mutation sufficient to reduce the coloration of biomass produced by the strains. Biomass produced from such strains can be used in the manufacture of baked goods, gluten free foods, beverages, high lipid algal flours, and other foods. Pigments such as carotenoids and chlorophyll can be undesirable for consumer acceptance when incorporated into foods such as mayonnaise, yogurt, and white sauces that are not traditionally associated with colors such as yellow, red, orange and green. Some pigments, such as chlorophyll, can also create undesirable taste profiles. Use of reduced pigment microalgal biomass expands the range of food products that can be manufactured with healthy lipid profiles. High protein containing biomass of the invention, also reduced in pigmentation, is also incorporated into products such as meat analogues, nutritional bars and meal replacement beverages. The reduced pigmentation microalgae also allow for incorporation of higher amounts of biomass into certain food products that could otherwise be achieved using highly pigmented microalgal biomass. Methods of generating novel reduced pigment microalgae are disclosed herein. The strains provided by the invention are also useful in the manufacture of healthy, neutral colored extracted triglyceride oils.

The invention is a non-surgical method for the eradication of pigmentation and scar tissue from an area of skin. The method comprises repeatedly puncturing the area of skin with an array of needles. As the needles are inserted into the skin, the needles and surface of the skin are washed with a clean solution. As the needles are withdrawn from the skin, the flow of clean solution ceases and the dirty solution, which contains cellular fluids and pigments released by the action of the needles, is removed from the surface. The invention is also a solution, which is used to clean the needles and to aid in destroying the pigment containing cells, and an apparatus, which is especially designed to move the needles into and out of the surface of the skin and to provide synchronization of the motion of the needles and flow of the solution such as to maximize the effectiveness of the method.

Methods and apparatus are described that provide the ability to estimate the diffuse reflection component of an image of tissue such as skin captured without cross-polarization. It is thereby possible to estimate skin pigmentation information from an image of skin captured conventionally, such as, for example, a total reflection image, obtained in a conventional manner by shining white light on the skin and capturing the reflected light. The image may also be a partially diffuse reflection image, such as a low quality cross-polarized image. The diffuse reflection component of a captured image can then be further processed to obtain Red and Brown pigmentation images, useful for indicating the distribution of hemoglobin and melanin, the primary chromophores of skin. Additionally, a standard captured image of skin can be analyzed to obtain an estimate of the surface reflection component of the reflected light. The surface reflection component can then be used to generate a surface reflection image, useful for showing the distribution of light on the skin and to highlight superficial features such as wrinkles, fine lines, folds, pores, texture, and visible spots.

Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth and have at least one radiation emitting element coupled to an apparatus body to irradiate a portion of the oral cavity with phototherapeutic radiation along multiple directions. In one aspect, the apparatus is configured to direct radiation to at least one portion of the oral cavity, such as the teeth, cheeks, tongue, palate, throat, lymphatic tissue, blood, glands, follicles, collagen, pigmentation or facial tissue, generally. The apparatus can further include bristles to provide a phototherapeutic toothbrush. Alternatively, the apparatus body can be adapted for placement in a fixed position relative to the oral cavity during phototherapy.

The present invention describes systems and methods for treating disorders and / or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and / or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.

The present invention describes systems and methods for treating disorders and / or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and / or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.

Disclosed are stable compositions which are effective as skin whitening agents, comprising alpha, beta or gamma substituted mono-, di or polyhydroxy or polycarboxy carboxylic acids; mono-, di, tri or polyhydroxy alkyl compound; and effective amounts of an inhibitor of tyrosinase and a pigmentation reversing reagent. Also disclosed are methods of forming stable compositions of the type described above.

A composition is provided to treat and / or prevent for treating skin conditions including fine lines and wrinkles, acne rosacea, surface irregularities of the skin and hyper-pigmentation melasma of the skin, which includes use of a topically applied composition such as an ointment, lotion, cream, serum, gel or pad applied formulation, containing an effective amount of polyphenols, such as green tea based polyphenols, including but not limited to catechins, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicathechin 3-gallate (ECG) and epicatechin (EC). The formulation is preferably composed of 90 percent polyphenol isolates, derived from green tea with potent antioxidant properties, to assist in minimizing free-radical induced skin damage.

The present invention generally relates to improved medical devices, systems, and methods, with exemplary embodiments providing improved cooling treatment probes and cooling treatment methods and systems. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling of the skin of the patient during a cooling treatment. Additionally, embodiments may limit adverse side effects such as hyperpigmentation. It has been found that the freezing behavior (frequency and time to freeze) can be modified by adjusting the thermal parameters of the cooling applicator. Accordingly, in some aspects of the invention, a method of treating the skin may be provided where the thermal parameters of the cooling applicator are adjusted during treatment.

An extract from leaves of mulberry is disclosed. The extract has an IC50 value sufficient to inhibit α-glucosidase I. The extract may comprise 5-40% (w / w) total imino sugars and 20-70% (w / w) total amino acids. The extract may reduce the production of melanin for the treatment of such ailments or diseases caused by pigmentation as freckle, chloasma, striae gravidarum, sensile plaque and melanoma. The extract may also control blood glucose level.

The present invention relates to compositions useful in treating hyperpigmentation and the various signs of dermatological aging in human skin. The present invention also relates to cosmetic compositions and methods of using such compositions that improve the aesthetic appearance of skin. Further, the present invention relates to methods of applying the compositions to the skin to effect treatment and to improve the aesthetic appearance of skin, particularly, by providing anti-aging benefits to the skin. These and other objects of the present invention are achieved by a method and composition that comprises (a) a de-pigmenting agent or anti-aging agent in an amount effective to prevent, treat and / or ameliorate pigmentation or the various signs of aging at an area of skin to which it is applied, and (b) a cosmetically or pharmaceutically acceptable vehicle. Suitable de-pigmenting agents include 3,3'-thiodipropionic acid, thiazolidine-2-carboxylic acid, Kaempferol-7-glucoside, perilla oil, and clofibrate and clofibrate analogs and / or derivatives, as well as those set forth below. Suitable anti-aging agents include 3,3'-thiodipropionic acid and / or its derivatives.

Apparatus and methods are provided to control a device, such as a light emitting dermatologic or cosmetic treatment device, and ensure that the device is in contact with skin while also determining the pigmentation level of skin. One or more light sources contact the skin and one or more detectors measure spectral remission from the skin. The obtained remission measurements are compared with known skin spectral remission values, and calibration allows measurements of absolute remission to be converted to fractional remission values. Skin pigmentation levels are compared to known base-line levels to determine and control appropriate treatment parameters. A temperature sensor allows correction for temperature variations. The apparatus may or may not be incorporated into the treatment device.

A composition is provided to treat and / or prevent for treating skin conditions including fine lines and wrinkles, acne rosacea, surface irregularities of the skin and hyper-pigmentation melasma of the skin, which includes use of a topically applied composition such as an ointment, lotion, cream, serum, gel or pad applied formulation, containing an effective amount of polyphenols, such as green tea based polyphenols, including but not limited to catechins, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicathechin 3-gallate (ECG) and epicatechin (EC). The formulation is preferably composed of 90 percent polyphenol isolates, derived from green tea with potent antioxidant properties, to assist in minimizing free-radical induced skin damage.

Methods and apparatus are described that provide the ability to estimate the diffuse reflection component of an image of tissue such as skin captured without cross-polarization. It is thereby possible to estimate skin pigmentation information from an image of skin captured conventionally, such as, for example, a total reflection image, obtained in a conventional manner by shining white light on the skin and capturing the reflected light. The image may also be a partially diffuse reflection image, such as a low quality cross-polarized image. The diffuse reflection component of a captured image can then be further processed to obtain Red and Brown pigmentation images, useful for indicating the distribution of hemoglobin and melanin, the primary chromophores of skin. Additionally, a standard captured image of skin can be analyzed to obtain an estimate of the surface reflection component of the reflected light. The surface reflection component can then be used to generate a surface reflection image, useful for showing the distribution of light on the skin and to highlight superficial features such as wrinkles, fine lines, folds, pores, texture, and visible spots.

An apparatus for removing a pigmented section of skin, comprises a) a skin puncturing device; b) an array of one or more needles connected to said device for puncturing the skin at said pigmented section; and c) a mediating member attached to said device and to suction means, for allowing said suction means to collect the mixture of the pigments with the cellular fluids at said punctured section of the skin.

The invention provides a multi-effect restoring skin cream, which takes olive oil, simmondsia chinensis seed oil, wheat embryo oil and shea butter as the raw materials, and is prepared by the following steps: dissolving emulsifier cetearyl glucoside in an oil phase directly, slowly adding the oil in water while stirring, then adding the mixture in an emulsion pot in sequence by a filter, stirringand emulsifying the mixture for a given period of time at 70 to 80 DEG C to prepare oil / water-based emulsion body, and adding multiple pure natural plant active matters, such as aloe, trehalose, natural vitamin E, ginger extract, yeast extract and rose essential oil (natural essence). The skin cream is rich in natural plant oil, blends multiple ingredients and has the unique effect to reduce the chromatosis caused by inflammation (ultraviolet light, stimulation and acne) and aging, help skin resist the stimulation from outside, relieve the pain from heat and sensitivity, reduce the skin temperature, prevent dry and crack and further recover and maintain the natural elasticity of the skin.

Methods, compositions and apparatus for restoring pigmentation to skin that has suffered pigment loss are described. The methods include creating a plurality of spaced-apart microchannels or voids in the skin and depositing into the micropore channels or voids a composition comprising at least one cell capable of producing melanin, a growth factor, and, optionally, a scaffolding material, a differentiation factor, a proliferation factor, and / or a pigment. Alternatively, a composition comprising a pigment can be deposited into the micropore channels or voids to restore pigmentation to the skin.

In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and / or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.

The invention discloses a rhodiola crenulata facial mask with whitening and moisturizing effects. The rhodiola crenulata facial mask is mainly prepared from rhodiola crenulata root extract, black tea extract, blueberry fruit extract, hydrolyzed silk and corresponding adjuvants. Rhodiola crenulata can nourish and moisturize skin and keep constant moisture and elasticity of the skin, has anti-oxidation and whitening functions and is called 'gold plant' in the Compendium of Materia Medica. Blueberry is honored as a 'skin cosmetic taken orally' and rich in anthocyanin which is a purely natural anti-aging nutrition supplement. Black tea can moisturize skin, promote blood circulation and activate cells, and also has antibacterial and refreshing functions and the like. The rhodiola crenulata body lotion, prepared from rhodiola crenulata serving as 'monarch', blueberry serving as 'minister' and black tea serving as 'assistant', can promote skin metabolism, enhance activity, reduce epidermal pigmentation, resist against oxidation and remove oxygen free radicals; and the rhodiola crenulata facial mask is fine and smooth, deeply moisturizes the skin, and enables skin to keep moist, soft, smooth and glossy for a long time.

A method and apparatus for selectively photobleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light and specifically two-photon excitation. Phototoxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.

The invention relates to a novel tyramine derivate and a method for preparing the compound. The invention also relates to a cosmetic or medical skin composition having the compound, as well as the application of the compound in the skin care field, in particular to the application in order to release the over-pigmentation.

The invention discloses a medicinal ointment for treating burns, wherein the active constituents mainly compirse alkanna tinctoria, baikal skullcap root, goldthread root, corktree bark, rhubarb horsetails, giant knotweed rhizome, bletilla striata, root of red rooted saliva, garden burnet root and auxiliary materials including excipient and sesame oil.

The invention discloses sweet osmanthus perfume which comprises the following 100 parts by volume of components: basic essential oil, sweet osmanthus essential oil, sweet osmanthus hydrolat, essential oil emulsifier and 95% ethanol. According to the invention, the advantages of high extraction quality, low equipment cost, simple operation, high extraction efficiency, no solvent residue, low top note loss and the like are achieved. The sweet osmanthus essential oil extracted from fresh sweet osmanthus is taken as a main ingredient, and the main ingredient, namely the sweet osmanthus essential oil has fragrant and elegant flavor, super penetrability, has the functions of deeply supplementing nutrition and water for skin, reducing the epidermal pigmentation of the skin, eliminating toxins, accelerating the metabolism of the skin, avoiding the aging of the skin, moistening and refreshing the skin so that the skin looks vital, moist, fresh and alive; and the obtained perfume has the advantages of good overall feeling, quietly elegant color and luster, harmonious and natural fragrance and long fragrance maintaining time, and has very high application value and broad market prospects.

Compositions for treating skin containing at least one extract from the genus Trametes and at least one viscosity enhancing synthetic polymer, and methods for whitening skin, treating skin for improvement, or treating skin disorders associated with pigmentation such as uneven pigmentation, skin mottling, or age spots or other dermatological disorders such as eczema, rosacea, hyperkeratinization, and so on.

A method and apparatus for selectively photobleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light and specifically two-photon excitation. Phototoxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.

The invention discloses a rhodiola crenulata eye cream with whitening and anti-wrinkle effects. The rhodiola crenulata eye cream is mainly prepared from rhodiola crenulata root extract, black tea extract, coix seed extract, honeysuckle flower extract and corresponding adjuvants. Rhodiola crenulata can nourish and moisturize skin and keep constant moisture and elasticity of the skin and has anti-oxidation and whitening functions. Known from Compendium of Materia Medica, coix seeds have the functions of 'nourishing facial appearance and keeping youth', whitening and removing freckles, contracting pores, excreting water and slimming bodies. Black tea can moisturize skin, promote blood circulation and activate cells. Honeysuckle flower, also named lonicera japonica, can improve the water keeping capability of the skin and form a natural water keeping screen. The rhodiola crenulata eye cream is prepared from rhodiola crenulata serving as 'monarch', coix seeds serving as 'minister', black tea serving as 'assistant' and honeysuckle flower serving as 'guide' under the support of adjuvants. The rhodiola crenulata eye cream can promote skin metabolism, enhance skin activity, reduce epidermal pigmentation and resist against oxidation and removing oxygen free radicals; and the rhodiola crenulata eye cream is fine and smooth, has certain whitening, moisturizing and anti-wrinkle effects andprevents generation of thin wrinkles near eyes.

The invention provides a method for preparing a human stem cell sourcing biobeauty raw material. The method includes the steps of obtaining protein suspension from a culture solution of human stem cells and human stem cell lysis, after hyperconcentration, preparing into human stem cell essence which is rich in cell growth components and has the efficacy of skin regeneration and repairing; performing further freeze drying, and preparing into freeze-dried powder capable of being stored in a -80 DEG C ultra low temperature refrigerator for a long time to serve as a biobeauty raw material for skin regeneration and repairing. The biobeauty raw material can be added to face cream, body lotion and toner to prepare regeneration and repairing face cream products, or added to facial masks to prepare regeneration and repairing facial mask products, or directly prepared into regeneration and repairing essence products, which is applicable to beauty of skin wrinkles, hyperpigmentation and scars.