61 results about "Hyperpigmentation" patented technology

The invention relates to a light loss repairing composition for improving skin resistance and application of the light loss repairing composition, and belongs to the technical field of cosmetics. The light loss repairing composition for improving the self resistance of the skin comprises the nannochloropsis oculata extract, the butterflybush flower extract and the bisabolol, all the components have a synergistic effect, ultraviolet light and blue light can be protected, and the light loss repairing composition has an anti-light aging effect and can be used for repairing the self resistance of the skin. And the mask has the effects of repairing skin barrier, relieving skin inflammation, improving redness, preventing hyperpigmentation, resisting aging, tightening skin, improving skin state and the like, and has the effect of improving self resistance of the skin.

The invention relates to a composition containing nucleic acid and polypeptide and application thereof. The composition comprises nucleic acid, polypeptide and auxiliary materials. The nucleic acid and the functional polypeptide are compounded and combined, the problems that a single polypeptide is short in half-life period and short in-vivo retention time are solved, meanwhile, the composition can effectively promote tissue regeneration, stimulate regeneration of fiber cells and collagen, repair skin barriers and improve wrinkles, and can effectively improve blood vessel microcirculation and reduce hyperpigmentation while resisting wrinkles in a synergistic mode. The product disclosed by the invention is produced by a sterile process, is high in safety, and can be applied to the medical cosmetology fields such as plastic and aesthetic surgery, trauma healing and the like.

Compositions comprising specific tetrapeptides, for use in methods for treating, preventing, minimizing, diminishing or reversing various signs of aging of the skin are provided. The compositions are useful in improving the firmness or elasticity of skin, smoothing of fine-lines or wrinkles, reducing skin pores and hyperpigmentation, and increasing skin thickness, radiance and / or softness.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin synthesis in melanocytes and inhibiting melanin body migration. Therefore, the peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

Compositions comprising specific tetrapeptides, for use in treating, preventing, minimizing, diminishing or reversing various signs of aging of the skin are provided. The compositions are useful in improving the firmness or elasticity of skin, smoothing of fine-lines or wrinkles, reducing skin pores and hyperpigmentation, and increasing skin thickness, radiance and / or softness.

The invention belongs to the technical field of polypeptides, and particularly relates to a novel synthetic polypeptide and a synthetic method and application thereof. The skin as the largest organ of the human body can visually reflect the aging level of the whole body. Skin senescence can be divided into endogenous senescence and exogenous senescence, the main manifestation of the cellular level is the senescence of fibroblasts in a corium layer, research shows that reactive oxygen species (ROS) is an important factor for promoting cell senescence, and the cell anti-senescence effect can be achieved by reducing the generation of ROS in cells. Melanin is a heterogeneous polyphenol-like polymer which is synthesized in melanin bodies and has a complex structure, the amount and distribution of the melanin not only determine the depth of the skin color, but also cause hyperpigmentation diseases due to metabolic disorder. In recent years, research finds that the polypeptide has excellent performance in skin care due to good biocompatibility and relatively strong biological activity. The polypeptide can rapidly permeate the skin through a specific receptor and activate the regeneration and repair functions of skin cells, so that the whitening and anti-aging effects are achieved. In addition, the action mechanism of the polypeptide is relatively mild, and the polypeptide is suitable for various skin types, especially sensitive skin. At present, although multiple polypeptide products exist in the market, most of the polypeptide products integrate a single function, and comprehensive products with double effects of whitening and anti-aging are lacked. Therefore, a polypeptide product with whitening and anti-aging effects is developed, the requirements of consumers can be better met, and the polypeptide product has important market value and application prospect.

The invention provides a red rice / mung bean fermentation mud film and a preparation method thereof.The preparation method comprises the steps that 1, red rice is weighed, a proper amount of water is added, or soaked mung beans are weighed, and after high-temperature sterilization, the mung beans are cooled to the room temperature, and a substrate is obtained; step 2, inoculating a schizophyllum commune seed solution or a lucid ganoderma seed solution into the substrate, and standing for fermentation culture to obtain a fermented product; and step 3, adding water into the fermented product, and sequentially carrying out homogenization, grinding, sterilization and preservative treatment to finally obtain the red rice / mung bean fermented mud film. According to the method, the red rice or mung bean fermentation product can be effectively utilized, the moisture retention performance and sensory comfort of the product are remarkably improved while the mud mask is endowed with strong cleaning power, and various mineral raw materials can be replaced or partially replaced to prepare the mud mask. Especially, the red rice fermented mud film has extremely strong immediate oil control performance and purification effect, good moisturizing and moisturizing effects, no irritation to skin melanocytes, no pigmentation after inflammation, and good skin smoothing effect.

The embodiment of the invention provides application of hydroxymethoxyphenyl decanone in preparation of a cosmetic composition for preventing squalene in sebum from being oxidized. According to the embodiment of the invention, the hydroxymethoxyphenyl decanone is used as an antioxidant to prepare the cosmetic composition, and when the cosmetic composition is applied to skin, squalene in sebum can be prevented from being oxidized; wherein the hydroxymethoxyphenyl decanone, as an antioxidant, can be used for reducing the peroxide value of squalene in sebum or inhibiting the squalene in the sebum from being oxidized into squalene peroxide products, so that lipid peroxidation of the squalene in the sebum is effectively inhibited or avoided; further, the problems of skin inflammation, hyperpigmentation, scurf and the like caused by squalene peroxide products can be defended and improved.

The peptide of the present invention inhibits melanosome sinking in keratinocytes and promotes melanosome degradation, thereby having a skin whitening activity. The peptide of the present invention can be used as an active ingredient of a drug for treating or preventing hyperpigmentation diseases caused by melanin hyperpigmentation, or as an active ingredient of a skin whitening cosmetic.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin body uptake in keratinocytes. The peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

The invention discloses ZIF-8 as well as a derivative, a preparation method and application thereof, relates to the field of biomedical nanomaterials, and aims to optimize a preparation process of ZIF-8 by taking TYR inhibition rate as an index and obtain ZIF-8 with stable performance. The IC50 value of the ZIF-8 obtained by the process to the TYR inhibitory activity reaches 1.67 mmol / L, and the effect is superior to that of a nicotinamide whitening agent; under the same mass concentration, the TYR inhibition activity of the nano material is obviously higher than that of UiO-66-NH2, N101, M100 and M101 nano materials. Furthermore, a ZIF-8 derivative can be prepared by doping Ca < 2 + > or Ni < 2 + >, so that the TYR inhibition activity of the ZIF-8 derivative is improved, the IC50 values of the ZIF-8 derivative to TYR modified by Ca < 2 + > or Ni < 2 + > are 0.99 mmol / L and 0.65 mmol / L respectively, and the inhibition effect is improved by 40% or above. According to the method disclosed by the invention, the batch difference is less than 5%, the safe concentration of the obtained ZIF-8 and the derivative thereof to cells is less than 120mu g / mL, and the ZIF-8 and the derivative thereof can be used as active ingredients to be prepared into cosmetics or medicines such as emulsion, essence, facial masks or cream and the like, and are used for preventing or treating hyperpigmentation diseases such as chloasma and freckles and the like.

The peptide of the present invention has skin whitening activity by inhibiting the incorporation of melanosomes into keratinocytes and promoting the degradation of melanosomes. The peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanosomes, or as an active ingredient in a cosmetic for skin whitening.

The peptide of the present application has a skin-whitening activity by inhibiting incorporation of melanin into keratinocytes and promoting degradation of melanin. The peptide of the present application can be used as an active ingredient in a medicament for treating or preventing a hyperpigmentation disease caused by excessive deposition of melanin, or as an active ingredient in a cosmetic for skin whitening.

Provided are compositions and methods for decreasing hyperpigmentation of a subject in need thereof. In some embodiments, the methods comprise administering a composition comprising a compound having a structure of Formulas (I) or (II), or a salt thereof.

The peptides of the present invention exhibit skin-whitening activity by inhibiting the absorption of melanosomes in keratinocytes. Therefore, the peptides of the present invention can be used as active ingredients in medicaments for treating or preventing hyperpigmentation caused by excessive melanosome deposition, or as active ingredients in cosmetics for skin whitening.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-aging repairing composition and a cosmetic. The anti-aging repairing composition comprises needle-like silica and a nucleic acid tetrahedron solution. According to the composition and the cosmetic, controlled skin injury is formed through the needle-like silica, skin pore blockage is relieved, natural stripping of aged cuticle is accelerated, microcirculation of skin cells below the cuticle is activated, the overall metabolic condition of epidermis is improved, a natural skin repairing mechanism is stimulated, and under the synergistic effect of tFNA, the skin can be effectively repaired. Synthesis of important construction substances such as collagen, elastin and hyaluronic acid is promoted, the skin barrier function is repaired, and the skin health state is improved. Therefore, various skin defects such as skin photoaging, roughness, relaxation, wrinkles, dryness, hyperpigmentation, sensitivity and angiotelectasis are remarkably improved.

A dual-surfaced exfoliating and cleansing cloth is disclosed, comprising a first side formed of knotted nylon mesh with raised, interlocking knots configured to exfoliate the skin through rolling friction, and a second side formed of a soft, absorbent fabric such as a bamboo-cotton blend or microfiber textile for gentle cleansing. The cloth may be reusable, machine-washable, quick-drying, and resistant to microbial growth. It can be used to treat common skin conditions including acne, keratosis pilaris, and hyperpigmentation by combining effective exfoliation with skin-safe cleansing in a single article. A corresponding method of manufacturing the cloth is also disclosed, involving the formation of a uniform knotted nylon mesh and integration with a soft textile layer.

The present application relates to a peptide having skin whitening activity and use thereof, and provides: a peptide consisting of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3; a composition for skin whitening comprising the same; a cosmetic composition comprising the composition for skin whitening; and a pharmaceutical composition for preventing or treating hyperpigmentation diseases comprising the composition for skin whitening.

The invention discloses a burn dressing and a preparation method thereof, and belongs to the technical field of burn dressings, the burn dressing comprises the following raw materials: sericin, polyethylene glycol, zein, calcium carbonate, sodium chloride, glycerol, perilla alcohol and quebracho resinol.The prepared dressing can reduce hyperpigmentation of wounds of patients, meanwhile can promote healing of burn wounds, and has a good application prospect. The pain is relieved.

The present invention relates to a compound having melanin production inhibitory activity and a composition for preventing, treating or ameliorating a hyperpigmentation disease, the composition comprising same as an active ingredient. The compound or a salt thereof, according to the present invention, was confirmed to have low cytotoxicity while exhibiting a melanin production inhibitory effect. Therefore, a composition comprising the compound or a salt thereof as an active ingredient, according to the present invention, not only can be used for preventing, ameliorating or treating a hyperpigmentation disease, but is also expected to have various applications in the field of skin beauty, such as skin whitening through the amelioration of hyperpigmentation.

This invention provides a topical ointment containing Yunnan white pearl powder, its preparation method, and its application, belonging to the field of traditional Chinese medicine. By incorporating myrrh extract, scutellaria baicalensis extract, and ceramides, the synergistic effect of these active ingredients not only achieves the basic effects of anti-inflammatory, antibacterial, and skin barrier repair, but also unexpectedly enhances the transdermal absorption rate of Yunnan white pearl powder essential oil, strengthens its anti-inflammatory effect, reduces irritation, and extends its shelf life. Furthermore, it can inhibit post-inflammatory hyperpigmentation, with effects far exceeding the combined efficacy of individual ingredients and conventional compound formulations.

The present invention provides compositions and methods for orally and / or topically treating skin diseases and conditions, such as acne, atopic dermatitis, psoriasis, facial redness, folliculitis, dry skin, itchy skin, hyperpigmentation, aging, wrinkles, etc., by administering to a subject in need thereof a pharmaceutical composition or dietary supplement comprising an in vitro grown grape cell line culture. Additionally, the present invention provides methods and compositions for treating skin conditions and diseases, such as acne, atopic dermatitis, psoriasis, facial redness, folliculitis, dry skin, itchy skin, aging, wrinkles, etc., by topically administering to a subject in need thereof a pharmaceutical composition or cosmetic composition comprising an in vitro grown grape cell line culture.

The invention relates to the field of biological medicines, and discloses application of isotretinoin to preparation of a medicine for treating acquired dermal plaque pigmentation. The isotretinoin disclosed by the invention plays a medicinal role in treating acquired dermal plaque pigmentation by inhibiting melanin synthesis of melanocytes, improving abnormal lipid components in sebum secretions of ADMH patients and improving a melanocyte microenvironment. According to the present invention, the new application of the isotretinoin in the preparation of the drug for treating acquired dermal plaque pigmentation is found through the further research on the existing drug isotretinoin, such that the effective treatment on the ADMH pigmentation is achieved, and the blank of the specific treatment drug in the field of the disease is filled.

The present invention relates to a personal care composition which brightens skin. It more particularly relates to a topical composition which is effective against hyperpigmentation. This is achieved by including in a topical composition (i) a retinoic acid precursor; (ii) a carboxylic acid functionalized heteroaromatic compound selected from one or more of nicotinic acid, picolinic acid, nicotinate, niacinamide, and picolinamide; (iii) an alkyl resorcinol; (iv) Inulin; and (v) a cosmetically acceptable vehicle.

The present invention relates to the non-therapeutic cosmetic use of a composition comprising at least one cyclopropenoid fatty acid for inhibiting the activity of stearoyl-CoA desaturase and for acting as depigmenting, lightening and / or whitening agent for human skin, mucous membranes, body hair and / or head hair and / or as an agent for removing pigment spots on human skin. The present invention also relates to a composition for the treatment of hyperpigmentation. According to one embodiment, the at least one cyclopropenoid fatty acid is chosen from malvalic acid and / or malvalonic acid.

According to the composition, rhizoma bletillae, radix angelicae, ramie roots, moutan bark and herba violae serve as raw materials, ultrasonic extraction is conducted through an ethanol solvent to obtain a traditional Chinese medicine alcohol extracting solution, and the traditional Chinese medicine alcohol extracting solution and auxiliary materials such as carbomer, propylene glycol and triethanolamine are compounded into hydrogel. The preparation process comprises the following steps: crushing the medicinal materials, carrying out ultrasonic extraction (optimal conditions are as follows: the ethanol concentration is 40%, the solid-liquid ratio is 1: 12, the time is 30 minutes, and the number of times is 3), and mixing the auxiliary materials. The hydrogel disclosed by the invention has remarkable oxidation resistance (the DPPH removal rate is 89.80 + / -0.24%) and a whitening effect (the tyrosinase inhibition rate is 78.41 + / -1.18%), is good in transdermal absorption and excellent in physical and chemical stability, and can be used for solving the problems of dull yellow skin, hyperpigmentation or anti-oxidation nursing and the like.

The present application relates to the field of cosmetic technology, and discloses a white muscardine polypeptide composite whitening and repairing composition, a preparation method and application thereof. The composition takes fermented white muscardine oligopeptide as a core functional ingredient, and is compounded with ethyl vitamin C and 4D hyaluronic acid. The composition realizes whole-pathway whitening through a wind-phlegm-stasis three-dimensional blocking mechanism, and has barrier repairing and anti-inflammatory soothing effects. The present application also discloses a preparation process of the composition. The white muscardine is subjected to biological fermentation and fractional purification to obtain low molecular active peptides with a molecular weight of 0.3-3 kDa. The double-bin compounding technology is used to ensure the activity of the ingredients. The prepared cosmetic is mild and non-irritating, and is suitable for sensitive skin, people with post-inflammatory hyperpigmentation, and post-medical beauty, and can realize the effects of brightening skin color, improving dullness, and lightening color spots, and has the advantages of traditional Chinese medicine beauty theory and modern biological technology.

This invention involves a liquid, Epigenetics mask composition with a specialized applicator device. This solution addresses existing issues in prior art by providing an eco-friendly, natural, cost-effective, sustainable and versatile formulation. The benefits of this applicable facial mask are unprecedented in targeting skin concerns and providing anti-aging properties. The Astragalus root extract base stimulates collagen production and improves elasticity by influencing gene expression on a cellular level. The combination of ingredients help enhance skin barrier function, provide antioxidant protection tone skin complexion. The results are long-lasting compared to existing products, and address any individual's unique needs regarding oxidative stress, hyperpigmentation, irritation, hydration and collagen synthesis.

The present application relates to a peptide having skin whitening activity and use thereof, and provides: a peptide consisting of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3; a composition for skin whitening comprising the same; a cosmetic composition comprising the composition for skin whitening; and a pharmaceutical composition for preventing or treating hyperpigmentation diseases comprising the composition for skin whitening.