The invention discloses methods for preparing and producing cigarettes with angelica keiskei. The cigarettes comprise 50 kilograms of tobacco shreds, 5 kilograms of angelica keiskei, 5 kilograms of herba portulacae, 1 kilogram of lavandula officinalis and 5 kilograms of fructus momordicae. The method for producing the cigarettes includes extracting medicine liquid; spraying the medicine liquid in the tobacco shreds; storing and fermenting the tobacco shreds; allowing the medicine liquid to be sufficiently absorbed by the tobacco shreds, drying the tobacco shreds and then winding cigarettes to obtain finished products. The methods have the advantages that selected raw materials contain anti-active oxygen [the anti-active oxygen includes hydroxyl free radicals, superoxide free radicals and hydrogen peroxide, oxygen activity can be generated in cells or tissues in normal life metabolic procedures, and different types of tumor, atherosclerosis, diabetes mellitus, liver injury and the like can be caused by environmental factors such as generation of smoking inductive oxygen, oxidative injury of intracellular lipid, proteins, DNA (deoxyribonucleic acid) and the like and induced oxidative stress], have antitumor activity, antioxidant activity, anti-inflammatory activity and antibacterial activity and are anti-HIV (human immunodeficiency virus) and anti-ulcer, accordingly, swollen sore throats, cough, faucitis and trachitis due to excessive smoking addition can be prevented and treated, respiratory tract mechanisms can be maintained, nose and throat mucitis can be treated, residual harmful substances in lungs can be removed, and active cells and the like of blood can be purified; tar can be effectively reduced, harm can be effectively lessened, and immune functions of the bodies of smokers can be improved.