The invention relates to the technical field of traditional Chinese medicine and concretely relates to a drug of traditional Chinese medicine for remedying skin disease and the preparation method and application of the drug. The drug of the invention is prepared by the raw materials of a rhubarb, a dried tangerine peel, a liquorice and a coptis chinensis. The drugs of the raw materials have good curative effect within the following weight range of 3 to 6 portions of the rhubarbs, 2 to 5 portions of the dried tangerine peels, 3 to 6 portions of the liquorice and 1 to 5 portions of the coptis chinensis. The drug of the invention has the functions of clearing heat and toxin, clearing fire, cooling blood, activating blood, dispersing tiredness, detumescence, acesodyne, removing putrefaction, generating muscle, diminishing inflammation and resisting bacteria and is used for remedying the furuncle, the carbuncle, the honeycomb-shaped tissue inflammation, the acne, the bedsore, the boil, the eczema, the strip-shaped herpes, the simplex herpes and the burn and scald with significant curative effect.