Poly (p-dioxanone) medical suture with anti-inflammatory capsule

Abstract

The utility model discloses a poly (p-dioxanone) medical suture with an anti-inflammation capsule, and relates to the technical field of medical sutures. The protein anti-inflammatory suture line comprises a suture line inner core, a protein adhesive layer, a protein microcapsule and anti-inflammatory drug particles, wherein the suture line inner core is made of a PPDO material. According to the utility model, the anti-inflammatory drug of the wound can be fully and comprehensively absorbed; the inner core of the suture line has good compatibility, and rejection and tissue inflammation are reduced; the suture line can be gradually degraded in the body and finally converted into carbon dioxide, water and the like, and the carbon dioxide, the water and the like are naturally discharged by the human body and do not need to be removed through a secondary operation, so that the infection risk possibly caused by the secondary operation is reduced, and the infection risk is reduced; the suture line has long strength maintenance time and can provide continuous support for the wound until the tissue is healed; the protein microcapsules and the anti-inflammatory drug particles are beneficial to reducing inflammatory reaction.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical sutures, in particular to a polydioxanone medical suture with anti-inflammatory capsules. Background Art

[0002] Sutures are widely used in medical surgeries, but they have some problems, such as difficulty in degradation and the possibility of infection. With the development of biomaterial technology, degradable sutures have gradually become a research hotspot.

[0003] However, the anti-inflammatory function of existing degradable sutures still needs to be improved. Therefore, the present technical solution has important clinical significance in providing a suture that has both good degradation performance and can provide anti-inflammatory effects. Utility Model Content

[0004] The utility model provides a polydioxanone medical suture with anti-inflammatory capsules, which uses PPDO material as the inner core of the suture, is coated with a protein adhesive layer on the surface, and protein microcapsules filled with anti-inflammatory drug particles are spaced apart and applied to the surface of the protein adhesive layer, thereby achieving the purpose of slowly releasing the anti-inflammatory drug; the suture not only has good biodegradability, but also can effectively inhibit inflammatory reactions and reduce the risk of postoperative infection; and solves the problems in the background technology.

[0005] In order to solve the above technical problems, the present invention is achieved through the following technical solutions:

[0006] The utility model discloses a polydioxanone medical suture with anti-inflammatory capsules, comprising a suture inner core, the outer surface of which is evenly coated with a protein adhesive layer, protein microcapsules are coated at intervals on the surface of the protein adhesive layer, and anti-inflammatory drug particles are filled in the protein microcapsules.

[0007] Furthermore, the inner core of the suture is made of PPDO material, specifically polydioxanone material.

[0008] Furthermore, the anti-inflammatory drug particles are particles with a diameter of 1-5 μm.

[0009] Furthermore, the protein adhesive layer is made of fibrin glue and is evenly coated on the outer surface of the inner core of the suture.

[0010] Furthermore, the protein microcapsule has a thickness of 1 μm and a radius of 4 μm.

[0011] Furthermore, the interval between two adjacent protein microcapsules is 5-10 μm.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] (1) The PPDO suture is used as the inner core, the thickness of the protein adhesive layer is 1 μm, the radius of each protein microcapsule is 4 μm, and the spacing between each microcapsule is 5 to 10 μm. The microcapsules are spaced at a certain distance to ensure that the anti-inflammatory drug is fully absorbed by the wound;

[0014] (2) Biocompatibility and biodegradability: PPDO material has good compatibility with human tissue, reducing rejection reactions and tissue inflammation; the inner core of the suture can gradually degrade in the body and eventually convert into carbon dioxide and water, etc., which are naturally excreted by the human body, without the need for secondary surgery to remove it, thus reducing the risk of infection caused by secondary surgery;

[0015] (3) Strong maintenance: PPDO sutures have a long maintenance time and can provide continuous support for the wound until the tissue heals;

[0016] (4) Anti-inflammatory effect: Sutures with protein microcapsules and anti-inflammatory drug particles can gradually release anti-inflammatory drugs during wound healing, helping to reduce inflammatory responses and accelerate healing;

[0017] (5) Easy operation: The monofilament structure makes knotting and suturing easier, shortening the operation time.

[0018] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0020] Figure 1 This is a schematic structural diagram of a polydioxanone medical suture with anti-inflammatory capsules according to the present invention;

[0021] In the accompanying drawings, the components represented by the reference numerals are as follows:

[0022] 1- suture inner core, 2- protein adhesive layer, 3- protein microcapsule, 4- anti-inflammatory drug particles. DETAILED DESCRIPTION

[0023] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0024] In the description of the present invention, it should be understood that the terms "outer surface", "inner", "interval" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0025] See also Figure 1 As shown, the utility model is a polydioxanone medical suture with anti-inflammatory capsules, comprising a suture inner core 1, the outer surface of the suture inner core 1 is evenly coated with a protein adhesive layer 2, protein microcapsules 3 are coated at intervals on the surface of the protein adhesive layer 2, and anti-inflammatory drug particles 4 are filled in the protein microcapsules 3; the anti-inflammatory drug particles 4 include conventional anti-inflammatory drugs such as amoxicillin, cefuroxime axetil and levofloxacin tablets.

[0026] The inner core 1 of the suture thread is made of PPDO material, specifically polydioxanone material.

[0027] The anti-inflammatory drug particles 4 are particles with a diameter of 1-5 μm.

[0028] The protein adhesive layer 2 is made of fibrin glue, which is evenly coated on the outer surface of the suture core 1. Fibrin glue is an existing material. Fibrin glue is a biodegradable gel-like substance made by activating and agglomerating fibrinogen in human or animal plasma.

[0029] The thickness of the protein microcapsule 3 is 1 μm and the radius is 4 μm. Compared with other types of microcapsules, the protein microcapsules have better thermal instability, pH sensitivity, encapsulation efficiency and antioxidant capacity.

[0030] The interval between two adjacent protein microcapsules 3 is 5-10 μm.

[0031] The preparation method of the polydioxanone medical suture with anti-inflammatory capsules corresponding to the technical solution is as follows:

[0032] First, PPDO primary silk is spun using a melt spinning machine, and then coated with a protein adhesive layer 2. At the same time, protein microcapsules with anti-inflammatory drugs as the core layer can be produced. Finally, the microcapsules are evenly coated on the surface of the primary silk at equal intervals.

[0033] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. The preferred embodiments do not describe all details in detail, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the contents of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A polydioxanone medical suture with an anti-inflammatory capsule, comprising a suture core (1), characterized in that: The outer surface of the suture inner core (1) is uniformly coated with a protein adhesive layer (2), the surface of the protein adhesive layer (2) is coated with protein microcapsules (3) at intervals, and the protein microcapsules (3) are filled with anti-inflammatory drug particles (4).

2. The polydioxanone medical suture with anti-inflammatory capsules according to claim 1, characterized in that: The suture inner core (1) is made of PPDO material.

3. The polydioxanone medical suture with anti-inflammatory capsules according to claim 1, characterized in that: The anti-inflammatory drug particles (4) are particles with a diameter of 1-5 μm.

4. The polydioxanone medical suture with anti-inflammatory capsules according to claim 1, characterized in that: The protein adhesive layer (2) is made of fibrin glue and is evenly coated on the outer surface of the suture core (1).

5. The polydioxanone medical suture with anti-inflammatory capsules according to claim 1, characterized in that: The protein microcapsule (3) has a thickness of 1 μm and a radius of 4 μm.

6. The polydioxanone medical suture with anti-inflammatory capsules according to claim 1, characterized in that: The interval between two adjacent protein microcapsules (3) is 5-10 μm.

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