26 results about "Renal function" patented technology

The application discloses application of tomato saponin in preparation of a uric acid reducing composition and belongs to the technical field of biological medicine. The uric acid reducing composition comprises 80-240 parts of tomato saponin, 50-120 parts of momordica charantia saponin, 25-100 parts of fruit and vegetable extract, 10-20 parts of schizonepeta turczanovii extract, 10-20 parts of terminalia catappa leaf extract and 40-100 parts of soluble dietary mixture. Animal experiment verification shows that the composition can effectively reduce blood uric acid level and improve kidney function through the synergistic effect of multi-target points such as inhibition of uric acid synthesis, promotion of uric acid excretion, anti-inflammatory kidney protection and metabolic regulation, and a safe and efficient solution is provided for hyperuricemia.

The application relates to a chronic kidney disease prediction method based on clinical information graph representation, belongs to the technical field of computer-aided diagnosis of chronic kidney disease (CKD), and aims to solve the problem of missed diagnosis caused by the fact that the kidney function index of early CKD is not obvious. The incidence of CKD is high, the early symptoms are hidden, and the disease is easy to be missed, thus developing into end-stage renal disease. Therefore, the application provides a chronic kidney disease prediction method based on clinical information graph representation. The method first extracts fundus image and clinical index features; the clinical index is fused into a clinical index joint feature through text embedding and numerical feature fusion, and the joint feature is fused with the fundus image feature through cross-modal attention; the similarity between subjects is calculated based on the fused feature, and a subject relationship graph is constructed by using an adaptive dynamic threshold mechanism; finally, a hybrid graph neural network is used for graph representation learning, pathological similarity between subjects is mined, and accurate prediction of chronic kidney disease is realized. The application can improve the detection rate of early CKD and is applied to non-invasive early screening and risk early warning.

This invention provides a novel raw material that, for cats, which exhibit unique characteristics in their kidneys compared to other mammals, can inhibit the decline in feline kidney function and improve coat condition while maintaining the form of cat food or other feeds. When using a poorly soluble soybean protein raw material with a characteristic amino acid composition of less than a glutamic acid (Glu) to leucine (Leu) mass ratio of 2, and an NSI of 10%–60%, the decline in feline kidney function can be inhibited and coat condition improved through small-scale intake. This raw material can also be obtained as undigested residue from the soybean peptide manufacturing process.

The present application relates to the technical field of medical information processing, in particular to an abnormal event automatic classification and recording method in a kidney disease follow-up system, comprising collecting kidney function parameters and symptom codes, identifying abnormal sequences, extracting time anchor points and characteristic identifiers, calculating flip frequency and amplitude, constructing a feature vector to evaluate risk and generating event classification records. In the present application, by constructing an abnormal trigger ordered sequence and extracting anchor points to determine composite features, combining symptom flip frequency to construct a persistence intensity coefficient, quantifying disease complexity from the dimensions of time evolution and etiology coupling, using a multi-dimensional feature vector to fuse physiological amplitude and statistical characteristics, obtaining disease risk probability values through weighted calculation, realizing the transition from qualitative classification to quantitative risk grading, solving the false alarm and missed alarm problems caused by single index determination, providing dynamic diagnosis basis containing risk level for clinical, significantly improving the recognition accuracy and intervention timeliness of the hidden deterioration trend in kidney disease follow-up.

The present disclosure provides a bioengineered kidney construction method based on organoids and acellular scaffolds, which comprises first injecting pro-vascular stem cells into a kidney acellular scaffold material, and then culturing for several days through fluid circulation perfusion, and then injecting kidney organoids (KIO) into the scaffold material for perfusion culture after the kidney acellular scaffold material is recellularized. The bioengineered kidney obtained by the method of the present disclosure can be used as a graft for replacing kidney function. The present disclosure also provides a kidney organoid culture and expansion method, and the organoids obtained by the method contain not only kidney parenchymal cells such as glomerular cells and renal tubular cells, but also blood vessels and immune cells, which provides a good source of kidney parenchymal cells for the preparation of tissue-engineered kidneys.

This invention relates to the field of veterinary drug technology, specifically providing a veterinary carbofen injection and its preparation method. The veterinary carbofen injection comprises carbofen, emodin, luteolin, coumarin, astragalus, wolfberry, schisandra, resveratrol, and other components. The veterinary carbofen injection of this invention incorporates emodin and luteolin for compound anti-inflammatory effects, reducing the dosage of carbofen and alleviating the burden on the kidneys, while also minimizing the development of drug resistance. The addition of astragalus, wolfberry, and schisandra extracts protects the kidneys, regulates immunity, and prevents kidney damage, ultimately achieving the effect of compound anti-inflammatory treatment while avoiding kidney damage.

The present application relates to the field of biotechnology, in particular to astaxanthin and dihydroquercetin co-loaded liposome and its application in preparation of uric acid-lowering products. According to the steps of "in vitro function screening - optimal ratio determination - co-loaded liposome construction - surface coating and stabilization treatment - uric acid-lowering application verification", the obtained system is verified through physicochemical characterization, stability test and animal experiment. The results show that the co-loaded liposome can reduce the serum uric acid level of high uric acid model mice, inhibit the activity of liver xanthine oxidase, and improve the related indexes of kidney function and histopathological damage.

This invention discloses a method for constructing a traditional Chinese and Western medicine-integrated kidney disease prediction model, belonging to the field of medical prediction model construction technology. The method includes: collecting Western medicine clinical data covering indicators such as kidney function and routine urine tests, and traditional Chinese medicine diagnostic data including symptoms, signs, tongue and pulse characteristics; ensuring consistent and complete fields through standardized template recording; processing missing data using multiple imputation and mode imputation methods, and removing outlier data using box plots and isolated forest algorithms; standardizing and encoding numerical and categorical data respectively; and extracting features through recursive feature elimination and word embedding techniques. This method achieves deep integration of traditional Chinese and Western medicine data, overcoming the limitations of single models. The model captures comprehensive features, has stable predictive performance, strong generalization ability, adapts to different medical scenarios, ensures data security, offers flexible deployment options, assists in precise clinical decision-making, promotes the implementation of early kidney disease prediction technology, and provides support for early detection and intervention of kidney disease.

Provided herein are methods and compositions for treating kidney-related disease conditions and complications, such as Berger's disease, and for preventing transplant rejection. For example, the present disclosure describes a method of improving function of a transplanted kidney in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds CD40 ligand.

This disclosure relates to administration of a combination of: 1) about 100-110 mg, about 104-106 mg, or about 105 mg of bupropion hydrochloride, or a molar equivalent amount of the free base form or another salt form of bupropion; and 2) about 40-50 mg, about 44-46 mg, or about 45 mg of dextromethorphan hydrobromide, or a molar equivalent amount of the free base form or another salt form of dextromethorphan in certain patient populations, such as patients having moderate renal impairment, patients receiving a concomitant strong CYP2D6 inhibitor, patients who are known CYP2D6 poor metabolizers, those in need of an NMDA antagonist that does not cause dissociation, and those at risk of QT prolongation.

This invention relates to the field of pharmaceutical technology, specifically disclosing the application of SRPX2 inhibitors in the preparation of drugs for treating renal fibrosis, including SRPX2 inhibitors. SRPX2 inhibitors regulate the expression of iron metabolism-related proteins by inhibiting the binding of SRPX2 to IRP1, a key regulatory protein in iron metabolism, thereby restoring iron homeostasis and alleviating renal fibrosis. In patients with chronic kidney disease and animal models of renal fibrosis, SRPX2 is highly expressed in renal tubular epithelial cells and is positively correlated with the degree of fibrosis. The use of SRPX2 inhibitors can significantly reduce the pathological changes of renal fibrosis and improve renal function. This invention provides a new treatment strategy and drug candidate for renal fibrosis.

The present application relates to a kind of hydrolyzed sheep liver powder, cat food and its preparation method and application, belong to animal feed technical field.The present application sheep liver is homogenized, composite enzyme hydrolysis, filtration, drying and obtains hydrolyzed sheep liver powder.Hydrolyzed sheep liver powder is made into cat food with chicken, oyster powder, chicken oil, salmon oil, cellulose, beef tallow, beer yeast powder, jujube seed powder, gastrodia powder and polygonatum sibiricum powder.The hydrolyzed sheep liver powder and cat food prepared with it can improve the anti-stress response ability of cat, relieve the anxiety and depression caused by stress, also can improve the food intake of cat under stress, and can maintain its normal growth, improve serum enzyme index, protein, lipid metabolism level to some extent, and protect liver and kidney function, with the abnormal fluctuation of physiological and biochemical indexes caused by stress state, relieve stress stimulation effect.The hydrolyzed sheep liver powder of the present application is derived from food raw materials, and is safer.

This invention discloses a traditional Chinese medicine composition for treating cerebrovascular diseases, belonging to the technical field of cerebrovascular disease drugs. The composition comprises the following components in parts by weight: 10-30 parts of Polygonatum sibiricum, 6-15 parts of Rosa laevigata, 6-12 parts of Euonymus alatus, 6-15 parts of Polygonum cuspidatum, 3-9 parts of Acorus tatarinowii, 3-10 parts of Alpinia oxyphylla, 3-6 parts of Aralia elata septum, 3-10 parts of Rhodiola rosea, 3-10 parts of Bletilla striata, and 1-6 parts of Cinnamomum cassia. This invention addresses the pathological characteristics of cerebrovascular diseases, including long disease courses, multiple risk factors, and involvement of multiple target organs. Through the systematic combination of ten herbs, it can simultaneously achieve cerebrovascular protection, nerve function repair, and protection against multi-organ damage. Animal experiments and clinical observations have confirmed that this composition can significantly improve patients' neurological deficit scores, reduce the incidence of complications, and has clear preventive and therapeutic effects on secondary complications such as stress ulcers and renal impairment, while also possessing antithrombotic and hemostatic properties and high safety.

Disclosed are methods of preventing or reducing loss of kidney function in a chronic kidney disease (CKD) patient having secondary hyperparathyroidism (SHPT).

The present application relates to the field of medicine, and more particularly to the use of aesculin or verbascoside in the preparation of a medicament for treating and / or preventing IgAN. The present inventors have found that aesculin and / or verbascoside can significantly improve proteinuria caused by IgAN and reduce inflammatory reactions, thereby playing a role in protecting kidney function, and do not have the serious shortcomings of clinically commonly used drugs, indicating that aesculin and / or verbascoside have a strong and low-toxicity effect in treating IgAN. In addition, aesculin and / or verbascoside are a natural compound, low toxicity and easy to be accepted by the human body.

Use of a traditional Chinese medicine in preparing a drug for preventing and treating nephritis. The traditional Chinese medicine is prepared from Taraxacum officinale, Polygonum cuspidatum, Sonchus oleroceus L., and Herba Scutellariae barbatae. Danio rerio is adopted for modeling. Animal experiments prove that the traditional Chinese medicine can be used for treating nephritis caused by aristolochic acid, protecting kidney functions and / or ameliorating renal dysfunction edema, and specifically, promoting glomerular filtration. 

The application relates to the technical field of medicines, and provides a traditional Chinese medicine composition for tonifying and a preparation method and application thereof. The raw material components of the traditional Chinese medicine composition for tonifying comprise 57-106 parts by weight of prepared rehmannia, 34-64 parts by weight of fried Chinese yam or Chinese yam roasted with bran, 23-43 parts by weight of poria, 29-53 parts by weight of wine lees, 7-13 parts by weight of wine schisandra, 23-43 parts by weight of salt eucommia, and 23-43 parts by weight of wine achyranthes. The traditional Chinese medicine composition for tonifying provided by the application has the effects of nourishing yin and strengthening yang, and benefiting qi and blood, and the zebra fish efficacy experiment proves that the traditional Chinese medicine composition has the effects of resisting fatigue, resisting aging and protecting kidney functions, such as reducing the incidence of kidney edema and improving the glomerular filtration function.

Methods of detecting proteins in biological samples from human patients having lupus nephritis and the use of proteins detected in biological samples to treat, diagnose, and monitor lupus nephritis and long-term kidney functional capacity in human patients.

The application discloses a multifunctional kidney ureteral catheter and relates to the technical field of medical devices; the multifunctional kidney ureteral catheter comprises a ureter, a detection pipeline and a detection device; the pressure sensor cooperates with the valve plate with switchable flow paths, so that the urine flow of the left and right kidneys can be detected at different times and respectively, unilateral kidney function independent monitoring is realized, the real working state of the double kidneys can be accurately reflected, the problem that the traditional mode can only measure the total urine volume and cannot judge unilateral abnormalities is avoided, and when the air bag leaks, the piston in the liquid storage shell can intuitively prompt medical staff and patients through position change, and the air bag inflation can be temporarily supplemented and maintained through normal saline, so that failure early warning is realized, the stent can be prevented from immediately falling off, and the use safety is improved.

The application provides a traditional Chinese medicine compound for resisting uric acid nephropathy, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine compound is composed of curcuma longa, astragalus membranaceus, angelica sinensis, berberis wilsonii, corn silk, plantago seed, chicory, triplaridium chinense and smilax riparia. The traditional Chinese medicine compound is reasonably matched, and has the effects of clearing heat and removing dampness, removing blood stasis and discharging turbidity, benefiting qi and invigorating the spleen, dredging collaterals and protecting the kidney. The traditional Chinese medicine compound can target the pathological process of uric acid nephropathy and protect the kidney tissue structure in the animal level, can improve the kidney function of patients, relieve the symptoms and improve the cure rate in the clinic, is safe and has no adverse reactions, and provides an efficient and safe new scheme for the clinical treatment of uric acid nephropathy.

The application discloses a kind of composition and its preparation in the application of reducing blood pressure and reducing blood sugar.The Health Originated Peptides (HOP) of homologous compound preparation developed in the application is composed of animal-plant composite peptide, polyphenol-rich product and various prebiotics, has good three-dimensional synergistic effect of antioxidation, anti-chronic inflammation and maintaining intestinal-X axis health, significantly reduces systolic pressure and diastolic pressure, significantly reduces the weight, blood pressure and blood sugar level of obese hypertensive mice, and has obvious weight loss effect.Toxicology test shows that HOP has no toxic side effect on liver and kidney function of mice, and can be taken for a long time.