4 results about "Angina" patented technology

The invention discloses an application of SNF2 protein derived from streptococcus angina extracellular vesicles in gastric cancer prognosis. The chromatin remodeling protein SNF2 derived from S.anginosus EVs can be combined with a transcription factor TEAD1, so that the transcription of the palmitoyl transferase ZDHHC11 is promoted together. Then, the stability of the ZDHHC11 is enhanced by catalyzing palmitoylation of PD-L1, and finally immune escape is induced. In addition, SNF2 also can activate AXL, CTGF, CYR61 and other carcinogenic targets at the downstream of TEAD1, thereby further accelerating the malignant progression of gastric cancer. In an in-vivo experiment, the intragastric administration of the S.anginosus EVs not only promotes the tumor growth of mice, but also significantly inhibits the infiltration of CD8 + T cells. Blocking of ZDHHC11 can effectively reverse immune escape, and has a synergistic effect with an anti-PD-1 therapy, so that the treatment effect is remarkably improved.

The present invention relates to the use of bacterial compositions having an arginine deiminase activity (inhibition of nitric oxide synthase by conversion of L-arginine to L-citrulline) of 1-1,000 μmol L-citrulline / h / g composition and a sphingomyelinase (ceramide generation) activity of 0.01-1.000 nmoles ceramides / h / g composition in the treatment and / or prophylaxis of airway diseases caused by viruses such as influenza viruses, coronaviruses, as SARS-CoV, MERS-CoV and SARS-CoV-2, avian viruses, respiratory syncytial virus (VRS), rhinoviruses, pneumoviruses, or respiratory failure induced or aggravated by viral infections, angina pectoris, pulmonary heart, respiratory distress, pulmonary edema, neonatal asphyxia, myocardial infarction, heart failure, respiratory failure Pickwick syndrome, pulmonary hypertension, pneumonia or even cystic fibrosis (CF) aggravated by viral infections.

The application discloses a quality detection method for active ingredients of a traditional Chinese medicine compound for dredging blood vessels and reducing blood sugar by using UPLC-Q / TOF-MS, and has the advantages of comprehensive detection components, high sensitivity and simple operation. 186 chemical components are identified, including 45 terpene components, 41 glycoside components, 19 organic acid components, 18 flavone components, 10 alkaloid components, 6 sugar components and 47 other components. The detection method can be applied to internal quality control standards, chemical component identification and intermediate component detection of the traditional Chinese medicine compound for dredging blood vessels and reducing blood sugar.

The external Chinese herbal medicine essential oil combined liquid medicine is characterized by being prepared from the following Chinese herbal medicine essential oil: rhizoma arisaematis, radix zanthoxyli, semen strychni, radix aconiti carmichaeli, herba ephedrae, kadsura pepper stem, rhizoma corydalis, pogostemon cablin, ligusticum wallichii, ginger, radix cynanchi paniculati, artemisia anomala, radix angelicae, melissa officinalis, cinnamon, mint and safflower carthamus. The traditional Chinese medicine has the effects of relaxing tendons and activating collaterals, promoting blood circulation to remove blood stasis and relieving swelling and pain; the traditional Chinese medicine composition has the effects of being high in medicine efficacy permeability, rapid in effect taking and capable of rapidly relieving the illness state, and can be used for preparing external application for treating diabetic eye diseases and heart diseases such as heart diseases, coronary heart diseases, heart discomfort or pain, stuffiness pain, angina pectoris, neck arteriosclerosis, plaques and static arterial thrombosis in cardiovascular and cerebrovascular diseases. The external medicine is used for relieving swelling and pain, soothing channels and activating collaterals, and promoting blood circulation to remove blood stasis. The invention provides a convenient, rapid and effective external medicine treatment mode for patients with the diseases.