42 results about "Hypoxemia" patented technology

The utility model discloses an adjustable continuous positive airway pressure ventilation device, relates to the technical field of positive pressure ventilation devices, and solves the problems that in the prior art, a CPAP device is complex in structure and high in manufacturing cost, the medical expense of a patient can be additionally increased, and popularization is not convenient. The device comprises a pressure air storage bag, the pressure air storage bag is communicated with an oxygen input mechanism and an oxygen output mechanism, the other end of the oxygen input mechanism is communicated with oxygen supply equipment, and the other end of the oxygen output mechanism is communicated with a tracheal catheter. The oxygen output mechanism is provided with a pressure gauge used for displaying the pressure in the airway and a pressure adjusting assembly used for adjusting the positive pressure of the airway. The utility model discloses can improve hypoxemia to a certain extent, prevent the possible respiratory system complication, promote patient's rehabilitation, and simple structure and principle, convenient operation, easy to handle, manufacturing cost is low, thereby effectively reducing patient's medical expenditure, is favorable for popularization.

Provided herein are high strength / high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (“Compound 1”), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

The present application belongs to the technical field of medicine preparation, and relates to application of a blood-nourishing oral liquid in preparation of medicine for improving blood oxygen saturation. The blood-nourishing oral liquid can improve blood oxygen saturation, improve hypoxemia, improve lung function, and has a preventive and / or therapeutic effect on lung injury, especially acute lung injury.

The invention provides a chest and abdomen compression device, a compression system based on big data and a control method, which are used for assisting a doctor in compressing the chest or abdomen of a respiratory suppression patient, and the chest and abdomen compression device comprises a power supply device, a shell, a reciprocating motion mechanism, a compression block, a microprocessor and a driving device, the reciprocating motion mechanism comprises a first gear disc, a transmission rod, a sliding block and a sliding block channel, an outer gear is arranged on the outer edge of the first gear disc and meshed with the driving gear, a disc protruding shaft is arranged on one face of the first gear disc, and a transmission chain of reciprocating motion force comprises the driving gear, the first gear disc, the disc protruding shaft, the transmission rod, the sliding block and a pressing block. Finally, the sliding block and the pressing block are driven to reciprocate, diaphragm movement is stimulated, and the occurrence rate of hypoxemia of intravenous anesthesia patients is reduced. The vital signs of the patient can be monitored and analyzed in real time through the sign monitoring module, and whether the patient is subjected to respiratory suppression or not and whether pressing needs to be started and executed or not is automatically judged.

The invention discloses a thoracic operation single-lung ventilation monitoring device and monitoring method based on an EIT technology, the thoracic operation single-lung ventilation monitoring device comprises a plurality of monitoring modules, each monitoring module comprises an electrode membrane and an electrode array, the electrode array is integrated on the electrode membrane, and the electrode membrane is provided with a first adhesive layer so as to be adhered to the body surface of a human body; the system further comprises a receiving host detachably arranged on the single side of the human body surface, a receiving module and a wireless module are arranged in the receiving host, the receiving module is electrically connected with the multiple electrode arrays so as to receive impedance change data of each electrode array, the receiving module is electrically connected with the wireless module, and the wireless module is electrically connected with the receiving module. The wireless module is electrically connected with an external EIT device, and the external EIT device receives impedance change data of each electrode array and converts voltage data into a two-dimensional cross-sectional image. The one-lung ventilation monitoring of the EIT technology during the thoracic operation can be realized, the protective ventilation of the lung is realized, the oxygenation index is improved, the occurrence rate of hypoxemia is reduced, and the pulmonary complications are reduced.

Methods and devices for increasing oxygenation levels in the blood supply and thereby treating the condition of hypoxemia. Multiple approaches such as pressure reduction in the pulmonary circulatory system, reducing triggering mechanisms in the main pulmonary artery and restricting flow in the pulmonary circulatory system are disclosed. Interventions associated with those approaches can including shunting, restrictors, compliance devices, pharmacologic substances, etc.

The utility model discloses a disposable high-flow oral oxygen inhalation tube which comprises an oral breathing nozzle and an oxygen catheter, the oral breathing nozzle comprises a breathing tube, a lip blocking piece and a connecting tube, and the breathing tube is detachably connected with the connecting tube. When the breathing tube is connected with the connecting tube, the lip blocking piece is clamped and fixed between the breathing tube and the connecting tube, and one end of the oxygen catheter is connected with the connecting tube. Oxygen is input through the oxygen catheter and enters the breathing tube through the connecting tube, when a patient holds the breathing tube in the mouth, the lip blocking piece is attached to the lip of the patient and is prevented from going deep into the oral cavity, and the oxygen catheter, the connecting tube and the breathing tube form a passage, so that the oxygen can be input into the oral cavity of the patient; therefore, the conflict that a nasal approach operation channel is shared during clinical painless bronchofiberscope examination is avoided, and the hypoxemia during the examination is prevented and treated.

Provided in the present invention is a photoplethysmography (PPG) measurement module, comprising: a light source module, which is configured to emit emission light having a light emission wavelength, wherein the light emission wavelength is selected from a hypoxemia-affected light waveband; and a light measurement module, which is configured to receive detection light that is obtained after PPG measurement is performed using the emission light.

The utility model discloses an oxygen path detection structure, and belongs to the field of oxygen path detection. An oxygen path detection structure comprises a front shell and a rear shell, and further comprises a first mounting plate fixedly arranged on the front shell, and a flow detection sensor is arranged on the first mounting plate; the second mounting plate is fixedly arranged on the front shell, and a concentration detection sensor is arranged on the second mounting plate; the fixing frame is arranged on the inner side wall of the front shell, and a pressure sensor is arranged in the fixing frame; the air inlet nozzle and the air outlet nozzle are arranged on the two sides of the top of the front shell respectively; according to the utility model, the flow, concentration and pressure of gas in an oxygen path can be detected, oxygen poisoning or hypoxemia of a patient caused by abnormal concentration can be avoided, and the problems of pipeline rupture or alveolar injury caused by overhigh pressure or insufficient oxygen supply caused by overlow pressure can be prevented.

The utility model relates to the technical field of medical instruments, in particular to a visual supraglottic oxygen uptake weak stimulation oropharyngeal airway device which comprises a wing plate, a tooth cushion and an arc-shaped tongue plate which are connected in sequence. The tongue plate is further provided with an arc-shaped pharyngeal cavity supporting plate. An oxygen pipe and a visual assembly are arranged on the inner side of the tongue plate and the inner side of the pharyngeal cavity supporting plate. According to the visual oxygen uptake and weak stimulation oropharyngeal airway device on the glottis, the pharyngeal cavity supporting plate is used for supporting the pharyngeal cavity structure, the structure in the pharyngeal cavity is displayed on the external display screen through the eyepiece, the change condition of the glottis closing amplitude is dynamically observed in real time, pretreatment is conducted in advance when the oxygen saturation degree does not decline, hypoxemia is effectively reduced, and the visual oxygen uptake and weak stimulation oropharyngeal airway device has the advantages of being simple in structure and convenient to use. An oxygen pipe at the front end of the oropharynx airway directly reaches the glottis for oxygen inhalation, and the throat part is a potential cavity gap and can play a role in pre-storing oxygen; the tongue plate and the pharyngeal cavity supporting plate are both made of medical silica gel elastic materials, stimulation to the tongue body and the throat in the oral cavity of a patient is weak, foreign body sensation is reduced, and comfort is improved.

The utility model relates to the technical field of medical oxygen inhalation equipment, and provides an oxygen inhalation assembly of an oxygen generator, which comprises an oxygen guide tube connected with the oxygen generator, an oxygen inhalation tube arranged at the tail end of the oxygen guide tube and two oxygen outlet tubes arranged on the oxygen inhalation tube, the oxygen inhalation assembly further comprises an oral-nasal mask detachably arranged on the oxygen guide pipe, a guide pipe is arranged on the oral-nasal mask, an oxygen dividing opening is formed in the oxygen guide pipe, a sealing valve is arranged on the oxygen dividing opening, and a second connector used for being in butt joint with the oxygen dividing opening is arranged at the end, away from the oral-nasal mask, of the guide pipe. The oxygen uptake effect of a nose oxygen uptake mode during gastroscopy operation is guaranteed, the requirement for oxygen uptake of the mouth and the nose of a patient at the same time can be met quickly when the patient suffers from hypoxemia, the operation burden of medical staff is reduced, and meanwhile extra discomfort and trouble brought to the patient are avoided.

The present invention relates to the field of membrane technology, and specifically provides a hollow fiber membrane and a preparation method thereof. The method of the present invention comprises: (1) co-extruding a spinning solution and a core liquid, spinning, curing and forming, to form a primary membrane; (2) washing and drying the primary membrane to obtain a hollow fiber membrane; the mass ratio of the spinning solution to the core liquid is (0.2-0.8):1; the spinning solution is composed of a polymer, alginate, an additive, an organic solvent and water; the core liquid is composed of an organic solvent, water and a ferrous salt, and the hollow fiber membrane is used for blood concentration. The prepared hollow fiber membrane is used for blood concentration. Compared with the prior art, the hollow fiber membrane of the present invention can not only improve hypoxemia after extracorporeal circulation heart surgery, but also has good anticoagulant properties.

The anaesthetic mask for the painless gastroscope comprises a mask body, a shaping module is arranged on the outer wall of one side of the mask body and comprises a fixing ring, the outer wall of one side of the fixing ring is fixedly connected with the outer wall of one side of the mask body, a fixing assembly is arranged on the outer wall of the fixing ring, a round hole is formed in the outer wall of one side of the mask body, and the fixing assembly is arranged in the round hole. The inner wall of the round hole is fixedly connected with a pipe fixing sleeve, the inner wall of the pipe fixing sleeve is fixedly connected with an anesthesia pipe opening, and three oxygen conveying holes are formed in the outer wall of one side of the mask. According to the anesthetic mask for the painless gastroscope, the sealing capacity of equipment in the working process is improved, and the problem that an existing anesthetic mask for the painless gastroscope cannot be adjusted according to facial features of a patient is solved by arranging the shaping assembly; and the risk of hypoxemia occurring in the gastroscopy process of a patient is greatly reduced, and the requirement of existing medical treatment is better met.

The invention relates to a construction method of a hypoxemia prediction model during painless gastrointestinal endoscopy. The method belongs to the technical field of medical model construction. In order to solve the problem that there is no reliable related prediction model for hypoxemia with a large sample size at present, the method comprises the steps that prediction factors related to hypoxemia risks are screened and verified through a logistic regression model of forward stepwise regression, prediction variables are determined, based on the prediction variables, an HAPPY-12K model is constructed through the logistic regression model, and the prediction factors related to the hypoxemia risks are determined through the HAPPY-12K model. And the HAPPY-12K model is verified and evaluated by adopting sample data of multiple centers and sample data of different races, so that the external validity of the model is improved. The model provided by the invention is helpful to predict and evaluate the hypoxemia of a patient during painless gastrointestinal endoscopy, and has better robustness, accuracy and clinical general applicability.

Provided in the present invention is a photoplethysmography (PPG) measurement module, comprising: a light source module, which is configured to emit emission light having a light emission wavelength, wherein the light emission wavelength is selected from a hypoxemia-affected light waveband; and a light measurement module, which is configured to receive detection light that is obtained after PPG measurement is performed using the emission light.

The invention belongs to the technical field of biomedicine, and relates to a hypoxemia risk prediction system based on multi-modal data, the hypoxemia risk prediction system comprises an input module and a hypoxemia prediction module; the input module is used for inputting data information of a patient subjected to painless gastrointestinal endoscopy, and the data information comprises a facial image and structured data of the patient subjected to painless gastrointestinal endoscopy; the hypoxemia prediction module is used for processing and analyzing the input data information to obtain a hypoxemia prediction result of a patient subjected to painless gastrointestinal endoscopy and outputting the hypoxemia prediction result; wherein a hypoxemia risk prediction model is carried in the hypoxemia prediction module. According to the hypoxemia risk prediction system, the facial image features of the patient subjected to painless gastrointestinal endoscopy and the structured data information can be combined to carry out hypoxemia risk prediction, and the prediction accuracy is high.

The present invention relates to the therapeutic use of acellular fat extract for lung diseases. Specifically, the present invention provides a use of acellular fat extract for preparing a composition or preparation, wherein the composition or preparation is used for one or more uses selected from the following groups: (i) preventing and / or treating acute respiratory distress syndrome and / or acute lung injury; (ii) preventing and / or treating hypoxemia; (iii) improving lung tissue inflammation; (iv) improving lung tissue damage; (v) preventing and / or treating systemic inflammatory response syndrome; (vi) preventing and / or treating multiple organ failure. The acellular fat extract of the present invention can effectively prevent and / or treat acute respiratory distress syndrome, acute lung injury, hypoxemia, lung tissue inflammation, lung tissue damage, systemic inflammatory response syndrome and multiple organ failure.

The application belongs to the technical field of medical equipment and biosensor, and specifically discloses an ICU bedside dialysis vital sign intelligent linkage system suitable for nasal cavity ventilation support. The system comprises a multi-source data fusion acquisition module, a ventilation-dialysis coupling state evaluation module, a multi-modal physiological situation awareness module, a risk evolution prediction module and a hierarchical early warning and intervention suggestion generation module. The interactive state of ventilation and dialysis is quantitatively evaluated, and dynamic physiological feature fusion and time sequence risk prediction are carried out based on the interactive state, so that hierarchical early warning and targeted intervention suggestions are finally generated, and early and accurate early warning and clinical decision support for dialysis-related hypotension and hypoxemia are realized.

The utility model relates to the technical field of lung function training, in particular to an oxygen inhalation tube capable of carrying out lung function training, which comprises an oxygen inhalation tube, a containing nozzle, an air blowing cylinder and a winding drum, and the winding drum is communicated with the air blowing cylinder. By means of the abdominal breathing device, the number of coaching training of medical staff can be reduced, the number of coaching training of the medical staff can be reduced when abdominal breathing or lip contraction breathing is carried out through intuitive winding drum changes and the design of the winding drum capable of being visually observed, and a patient can know the expiration strength through the intuitive winding drum changes; medical staff tutoring training can observe the expiration strength of a patient, the device is more visual and clear, the patient can see the training result of himself, subjectivity of the patient in the training process can be improved, training is actively matched, and hypoxemia can be avoided.

The embodiment of the invention relates to a method for detecting hypoxemia in a subject. The method comprises the following steps: (1) receiving a blood sample of the subject; (2) measuring a T2 relaxation time constant (T2P value) of blood cells (e.g., blood cell precipitates) in the blood sample; and (3) associating the measured T2P value with the hypoxemia. In some embodiments, the methods of the present disclosure further include the step of correlating the measured T2P value with a subject's susceptibility to one or more hypoxemia-related conditions. Other embodiments of the present disclosure relate to systems for detecting hypoxemia in a subject in accordance with the methods described in the present disclosure.

Provided herein are high strength / high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde ("Compound 1"), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

The present invention discloses a guiding core type anti-apnea hypoxemia catheter and its application, relating to the technical field of medical devices. The catheter includes a catheter unit, a connector unit and a supporting guiding core; the catheter unit includes a hollow hose that can be used for nasopharyngeal ventilation; the connector unit includes a connector head end and a connector tail end, the connector head end is detachably connected to the aforementioned first connector, and the connector tail end is used to connect external devices; the supporting guiding core includes a second connector and a flexible soft guiding core, and the soft guiding core includes a plurality of movable joint modules connected in sequence from head to tail; during intubation, by adjusting the connection angle between the movable joint modules, the soft guiding core is formed into a curved shape matching the nasopharyngeal cavity. The present invention adjusts the steering through the soft guiding core to guide the catheter to form a matching shape, significantly reducing the incidence of nasal mucosa injury and bleeding, improving the intubation success rate, being convenient to operate and facilitating the connection of external devices.

The invention discloses a medical gas pipeline protection device, and relates to the technical field of oxygen inhalation devices. The humidifying bottle comprises a humidifying bottle body, the outer wall of the humidifying bottle body is fixedly connected with a connecting pipe, and the outer wall of the connecting pipe is sleeved with an oxygen supply pipe. Through cooperation of a placing frame, an elastic telescopic arc rod, a movable arc block, a connecting short column, an abutting roller, a one-way bearing and a long groove, the abutting roller limits displacement of an oxygen supply pipe due to dragging force, so that the situation that oxygen supply is interrupted due to the fact that the oxygen supply pipe is dragged by external force and falls off from a connecting pipe is avoided, and the service life of the oxygen supply pipe is prolonged. The oxygen supply tube has the advantages that a patient cannot obtain required oxygen supply, especially for a critical patient or a patient who needs to inhale oxygen for a long time, the treatment and rehabilitation of the patient are severely influenced, acute reactions such as hypoxia and suffocation are possibly caused, and meanwhile, the friction force between the long groove and the oxygen supply tube is increased, so that the problem that the oxygen supply tube falls off is further prevented.

To provide a method and a pharmaceutical composition for treating disorders in which regulation of a gap junction channel, gap junction hemichannel, and / or pannexin channel is effective.SOLUTION: A method for treating a subject having glaucoma, diabetic macular edema (DME), ocular fibrosis, retinal perfusion disorder, or ocular hypoxia includes administering a therapeutically effective amount of gap junction regulator, connexin regulator, pannexin regulator, or pannexin channel regulator to an eye of the subject.SELECTED DRAWING: None

Described are methods of diagnosing or determining the risk of developing HYPO sepsis in a subject. Also disclosed are method diagnosis and treating or preventing HYPO sepsis in a subject. The methods comprise measuring expression of each of five to seven genes in a panel in a sample and comparing the expression of the five to seven gene with a predetermined control.

A suction device for deep cleaning of an artificial airway includes a ventilation tube, a blocking cuff, a suction head, and a suction tubing. The suction tubing is a tube with an annular cavity composed of an inner and outer tube. The suction head is gear-shaped and has a sputum storage cavity inside. A first through-hole and a second through-hole are respectively located on both sides of the suction head. This suction device is used for deep cleaning of an artificial airway. During suctioning, on the one hand, the cooperation between the blocking cuff and the ventilation tube completely isolates the negative pressure environment from the patient's body, preventing the negative pressure suction from drawing out air and causing a reduction in the amount of gas in the patient's peripheral lung tissue, leading to hypoxemia. On the other hand, the suction head can rotate, which scrapes off and smoothly removes sputum adhering to the walls of the artificial airway, achieving a deep cleaning effect.

To provide methods, compositions, and means for treatment or prophylaxis using fibroblasts possessing regenerative properties for the treatment of brain injuries including stroke, transient ischemic injuries, chronic traumatic encephalopathy, traumatic brain injury, and tauopathies.SOLUTION: Embodiments of the disclosure administer fibroblasts with regenerative properties, systemically, locally, or a combination of the two, concurrent with or subsequent to a brain injury. In some embodiments of the disclosure, fibroblasts or products thereof are administered intranasally, intrathecally, and / or intravenously.SELECTED DRAWING: Figure 1

The utility model relates to the technical field of medical instruments, and discloses a disposable double-channel oxygen inhalation nasal mask which comprises a nasal mask body, a nasal mask oxygen inhalation mechanism is arranged on the nasal mask body, a nasal catheter oxygen inhalation mechanism is arranged on the nasal mask body, grooves are formed in the two ends of the nasal mask body, and the nasal catheter oxygen inhalation mechanism is arranged in the grooves. Connecting mechanisms are arranged at the two ends of the nose mask body, and two carbon dioxide exhaust ports are fixedly connected to the lower portion of the nose mask body. According to the oxygen inhalation device, one end of the nasal mask inhales oxygen, the other end of the nasal mask is externally connected with the nasal catheter for oxygen inhalation, oxygen inhalation device modes can be switched at any time according to needs of patients, oxygenation and oxygen inhalation efficiency can be rapidly improved, the occurrence rate of hypoxemia is reduced, and meanwhile compliance and comfort are improved. The double-channel oxygen supply device is used for painless gastrointestinal endoscope and bronchoscope examination operations, normal oxygenation is better maintained due to double-channel oxygen supply, the safety of a patient is improved, and more operation time is strived for.

The invention discloses a sleep dyspnea assessment method based on limited lead signals, and belongs to the technical field of sleep dyspnea monitoring. The method aims at solving the problems that in the prior art, an oxygen deduction index (ODI) algorithm lacks a unified standard for baseline definition and event boundaries, the accuracy and consistency of evaluation results are affected, and a traditional lowest blood oxygen saturation (LSpO) index is prone to being interfered by artifacts. According to the method, an adaptive wave crest baseline is combined with a four-node time sequence constraint structure to detect an oxygen reduction event, an ODI {deviation, duration} index is calculated, and the duration and the descending depth of the event are quantified; a quantile interval average value index is introduced to replace traditional LSpO so as to stably evaluate the severity of the hypoxemia; by analyzing the difference value of the heart rate variability indexes before and after sleep, the regulation degree of sleep on the autonomic nervous system is quantified. The system is cooperatively realized by the wearable device and the data processing device, and is especially suitable for household and large-scale screening scenes. The key word in the figure 1 is sleep breathing disorder; obstructive sleep apnea; an oxygen reduction index; a wave crest baseline is self-adapted; detecting a four-node event; heart rate variability; a wearable device; and oxyhemoglobin saturation.

The invention provides a prediction method and device based on lung image processing, equipment and a medium. The method comprises the steps that a to-be-processed lung image and breathing parameters of a target user are acquired; performing spatial registration to obtain spatial registration result data; inputting the spatial registration result data into a graph neural network, constructing a functional connection relationship between lung segments, and obtaining a functional contribution weight of each lung segment; performing prediction by adopting a time sequence convolutional network; and inputting the time sequence registration result data and the biomarker data into a cross-modal prediction model to obtain tidal volume change data and hypoxemia risk data of the target user. Compared with an existing technical scheme based on static data, dynamic analysis of the lung state of the patient is achieved, and analysis hysteresis is reduced; in addition, dynamic prediction and analysis are achieved based on biomarkers, lung images and breathing parameters, and the defect that the prior art depends on single index prediction precision can be overcome through multi-modal dynamic modeling.