78 results about "Smooth muscle contraction" patented technology

The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

A method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

A system and method of modeling a circulatory system including a regulatory mechanism parameter. In one embodiment, a regulatory mechanism parameter in a lumped parameter model is represented as a logistic function. In another embodiment, the circulatory system model includes a compliant vessel, the model having a parameter representing a change in pressure due to contraction of smooth muscles of a wall of the vessel.

Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation comprises administering into the lungs as a gas compound with an NO group which does not form NO₂/NO_x in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and/or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO₂/NO_x in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.

A method for vitrification of a tissue or organ includes immersing the tissue or organ in increasing concentrations of cryoprotectant solution at a temperature greater than −15° C. to a cryoprotectant concentration sufficient for vitrification; cooling the tissue or organ at an average rate of from 2.5-100° C. per minute to a temperature between −80° C. and the glass transition temperature; and further cooling the tissue or organ at an average rate less than 30° C. per minute to a temperature below the glass transition temperature to vitrify the tissue or organ. After the vitrified tissue or organ has been stored, the tissue or organ may be removed from vitrification by warming the tissue or organ at an average rate of from 20-40° C. per minute to a temperature between −80° C. and the glass transition temperature; further warming the tissue or organ at a rate greater than 80° C. per minute to a temperature above −75° C.; and reducing the concentration of the cryoprotectant. Tissues or organs treated in this manner exhibit near normal functions, for example, blood vessels exhibit near normal smooth muscle contractility and normal graft functions.

The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.

The present invention provides, inter alia, methods and compositions for treating or ameliorating the effects of a disease characterized by altered smooth muscle contractility, such as e.g., asthma.

An herbal preparation comprised of sage, thyme and cumin is found to relieve the symptoms of inflammation and smooth muscle contraction. The preparation preferably comprises sage, thyme and cumin in the proportions 0.50, 0.43 and 0.07 respectively. The symptoms of menstrual cramps and asthma are relieved by administration of the preparation.

This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

The present invention relates to novel heteroaryl diazacycloalkane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

The invention relates to a novel muscarinic receptor antagonist and application thereof, relating to the preparation of novel ether compound of 3-azabicyclo(3, 3,1) nonanol and an optical isomer and quaternary ammonium salt thereof, and application of the compounds as medicament. The compounds show high affinity; and can be used for treating diseases or disease symptoms concerning the cholinergic systems of the central nervous system (CNS), and the peripheral nervous system (PNS), smooth muscle contraction, internal secretion, neurodegeneration, inflammation, aches, withdrawal caused by the termination of abuse of chemicals, and the like.

This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

The invention relates to novel application of pineapple leaf extract in the field of pharmacy, and particularly relates to second novel application of the pineapple leaf extract in the aspect of medicines. The pineapple leaf extract containing 30-80 percent of total phenol component is obtained by means of separation extraction. Experiment researches indicate that the pineapple leaf extract has an effect of promoting peristalsis of small intestine smooth muscles, and has a good relieving effect on diseases caused by decrease of intestine contraction. Specifically, the extract can be applied to preparation of medicine for treating degrease of intestinal smooth muscle contraction, slow intestinal peristalsis, enteroparesis and diseases caused by these symptoms.

The invention relates to the use of biochemical substances for a composition for the prevention and treatment of health conditions caused by constriction of smooth muscle cells in organs of the human body like high blood pressure, asthma, glaucoma and tinnitus.

The invention relates to a traditional Chinese medicine composition for treating endometritis of sheep. The traditional Chinese medicine composition comprises the following components by weight: 20-30 parts of climbing groundsel herb, 30-40 parts of radix sophorae flavescentis, 30-40 parts of scutellaria baicalensis, 30-40 parts of coptis root, 30-40 parts of bighead atractylodes rhizome, 30-40 parts of dandelion, 30-40 parts of herba epimedii, 50-70 parts of motherwort herb, 50-70 parts of codonopsis pilosula, 50-70 parts of herba aristolochiae, 50-70 parts of angelica sinensis, 30-40 parts of cowherb seed, 20-30 parts of pollen typhae, 20-30 parts of astragalus mongholicus and 20-30 parts of liquorice. The invention also discloses a preparation method of the traditional Chinese medicine composition for treating endometritis of sheep. By effectively combining the functions of four core medicines including angelica sinensis, motherwort herb, codonopsis pilosula and herba aristolochiae and eleven auxiliary medicines such as climbing groundsel herb, and by using the preparation method, the contraction of uterine smooth muscles is strengthened, the heat clearing, bacteriostatic and anti-inflammatory effects are achieved, the immunity of the organism is improved, and the pesticide effect of stopping bleeding and easing pain is realized, so that the cure rate of endometritis of sheep is effectively improved, the reproductive capacity of the sheep is enhanced, and financial loss of farmers is reduced. The traditional Chinese medicine composition has great significance for promoting the healthy development of sheep industry.

The invention relates to a substituted bicyclo(3,3,1)nonane ether compound and application thereof. The compound comprises an optical isomer, quaternary ammonium salt and medicinal compositions thereof. The compound can be used for treating diseases or symptoms which are associated with a central nervous system, a peripheral nervous system, smooth muscle contraction, endocrine, neurodegeneration, inflammation, pain, withdrawal symptoms caused by termination of abuse of chemical substances and the like.

The invention relates to an application of a Gs alpha gene in preparing a medicament for resisting abdominal aortic aneurysm. According to the invention, an important role of a Gs alpha gene is playedon regulating the phenotype transformation of smooth muscle and maintaining the contraction function of the smooth muscle by constructing a gene knock-out mouse specifically knocking out the Gs alphaof the smooth muscle; meanwhile, by pumping AngII subcutaneously to construct a mouse abdominal aortic aneurysm model, that the Gs alpha gene knock-out mouse can significantly increase the incidenceof abdominal aortic aneurysm is discovered; in addition, according to the invention, a lentivirus of the Gs alpha gene is prepared, and the lentivirus of the Gs alpha gene can be injected into the tail vein of the mouse, so that the incidence rate of the abdominal aortic aneurysm of the mouse can be obviously reduced. According to the invention, the Gs alpha gene is used as an action target to prepare or screen a medicament for resisting the abdominal aortic aneurysm, and the medicament has important significance in the treatment of the abdominal aortic aneurysm.