11 results about "Smooth muscle contraction" patented technology

The invention discloses a galiaceae-euphorbia tripsacus compound extract as well as a preparation method and vagina repair application thereof. The compound extract is prepared from galiaceae herbs and euphorbia tripsacus according to a scientific ratio through compound enzymolysis pretreatment, gradient ethanol solvent step-by-step extraction and double-resin series purification. According to the preparation method, the dissolution rate of the active components is remarkably increased by utilizing an enzymolysis wall breaking technology, the problem that the purity of the multi-polar components (tannin, flavone and polysaccharide) is difficult to increase and extract at the same time is solved through gradient extraction and series purification, and the purity of the total active components is more than or equal to 60%. The obtained composite extract has multiple effects of astringing and tightening, promoting regeneration of elastic fibers and improving contractility of smooth muscles, and is safe and non-irritant. The invention further discloses targeted sustained-release gel containing the extract, and the targeted sustained-release gel can be used for improving vaginal relaxation and deeply repairing private parts.

The invention relates to the technical field of molecular biology and medicine, and particularly discloses application of WWP1 in preparation of a medicine for preventing and / or treating aortic dissection, and relates to application of WWP1 in prevention and treatment of aortic dissection. Molecular biology experiment detection of the expression level of the WWP1 in aortic dissection aortic tissue and the expression level of smooth muscle cell contraction and secretion phenotype marker genes proves that the expression level of the WWP1 in an aortic dissection aortic tissue sample is obviously higher than that of a control aortic tissue; and overexpression of the WWP1 in an animal model significantly reduces the morbidity of the aortic dissection and improves the contraction phenotype of the aortic smooth muscle, i.e., the protectiveness of the WWP1 in the morbidity process of the aortic dissection is improved. Based on the research result, the WWP1 can be used as a drug target for screening, preventing and treating the aortic dissection.

The invention provides a traditional Chinese medicine composition for improving and / or treating irritable bowel syndrome as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises 1-30 parts of pogostemon cablin, 1-30 parts of ginseng, 1-30 parts of bighead atractylodes rhizome, 1-30 parts of poria cocos, 1-30 parts of radix puerariae and 1-30 parts of honey-fried licorice root. The traditional Chinese medicine composition combines six components, has the effects of invigorating spleen and replenishing qi, harmonizing stomach and promoting fluid, eliminating dampness in stomach and intestine and restoring rising and falling, and can mainly treat symptoms such as deficiency of spleen and stomach, vomiting and diarrhea and the like. Results of the embodiment show that the traditional Chinese medicine composition can effectively improve the high sensitivity condition of internal organs of IBS-D rats, reduce the defecation frequency and defecation amount of the IBS-D rats, inhibit autonomous contraction of colonic muscle strips of the IBS-D rats, inhibit contraction tension of the colonic muscle strips of the IBS-D rats under the condition of electrical stimulation, and improve the sensitivity of the internal organs of the IBS-D rats. The smooth muscle contraction effect caused by an antagonistic choline receptor stimulant carbachol and high-concentration potassium chloride is achieved.

This invention discloses a rifaximin nanoemulsion, its preparation method, and its application, belonging to the field of veterinary drug technology. The technical solution includes a rifaximin nanoemulsion comprising rifaximin, a compound essential oil, a surfactant, a co-surfactant, and water; the compound essential oil includes oregano oil, cinnamon oil, and tea tree oil. This invention prepares a rifaximin nanoemulsion using a compound of oregano, cinnamon, and tea tree oils as the oil phase, exhibiting both high antibacterial efficiency and high safety. The three essential oils have a synergistic antibacterial effect, complementing rifaximin through multi-target action, broadening the antibacterial spectrum, and showing significant inhibitory effects against various bacteria and fungi. It can enhance uterine smooth muscle contraction function by stimulating the synthesis and secretion of prostaglandins and oxytocin, providing potential support for uterine involution and endometrial repair. After administration, it can effectively reduce the number of inflammatory cells such as leukocytes and neutrophils in experimental dairy cows, significantly reduce purulent vaginal discharge, and restore the softness and elasticity of the uterus upon rectal examination.

In some aspects thereof, the present invention discloses compositions and methods for treating premature ejaculation utilizing tamsulosin at a 0.2 milligram dose administered orally or transdermally every 48 hours. Tamsulosin functions as a selective antagonist of alpha-1a and 1b adrenergic as well as 5HT1A serotonergic receptors implicated in seminal emission pathways. The quantity and frequency of dosing provides an optimal degree of reversible receptor blockade to mildly inhibit sympathetic and serotonergic mediated smooth muscle contraction kinetics governing seminal fluid secretion and transport. This marginally suppresses rate of emission to prolong intercourse without profoundly arresting physiological processes underlying ejaculation.

This invention provides a composition for treating dysmenorrhea due to cold in the uterus and relieving menstrual pain, and its preparation method, relating to the field of traditional Chinese medicine composition technology. The raw materials of this composition are: bergamot, oldenlandia diffusa, broom flower, evening primrose-morinda officinalis extract, mugwort, chuanxiong rhizome, angelica sinensis, astragalus, frankincense, myrrh, madder root, licorice, prepared rehmannia root, dried ginger, eucommia bark, peach kernel, safflower, Tween-80, sodium carboxymethyl cellulose, propylene glycol, methylparaben, and water. Through the synergistic effect of each component, it can regulate uterine smooth muscle contraction, relieve uterine smooth muscle spasms, improve blood rheology, effectively improve uterine microcirculation, help expel stagnant blood from the uterine cavity, and relieve menstrual pain. It has the effects of promoting blood circulation, removing blood stasis, regulating menstruation, relieving pain, replenishing qi and nourishing, and warming the middle jiao and dispelling cold, thus it can be used to treat dysmenorrhea due to cold in the uterus and relieve menstrual pain.

An orally deliverable composition for reducing veisalgia symptoms and nausea in a subject includes dihydromyricetin, acetylcysteine, and an antiemetic that decreases smooth muscle contraction in the digestive tract. The antiemetic is selected from the group consisting of phosphoric acid, ginger, peppermint, lemon, bismuth subsalicylate, and combinations thereof in an amount sufficient to decrease smooth muscle contraction and inhibit nausea in the subject. The composition is packaged as a viscous liquid, capsule, tablet or chewable form for oral administration. The composition preferably contains no free form taurine amino acid to avoid taurine-induced nausea. The composition may contain neuroprotective forms of taurine such as magnesium acetyl taurate which is not known to cause nausea in subjects and which can pass the blood brain barrier to protect the brain from some effects of veisalgia.

The invention belongs to the technical field of biological medicines, and particularly relates to an AAV vector for regulating smooth muscle contraction as well as a construction method and application of the AAV vector. The AAV vector for regulating and controlling the contraction of the smooth muscle, disclosed by the invention, is obtained by inserting a gene for regulating and controlling the contraction of the smooth muscle between restriction enzyme cutting sites of multiple cloning sites of a pssAAV-CBA-LUC-P2A-GFP-bGH-141 vector. The obtained AAV vector expresses an exogenous gene, such as a gene ACTA2 for regulating smooth muscle contraction, and has the advantages of long time and good stability. Animal experiments show that the AAV vector can directly increase the contractility of smooth muscle by regulating expression of smooth muscle contraction related genes such as ACTA2, so that the aim of treating related diseases such as gastroesophageal reflux disease, fecal incontinence and the like is fulfilled.

The invention relates to the technical field of medical instruments, in particular to an intelligent bladder temperature regulation and control system and method.The method comprises the steps that whether the bladder temperature is unbalanced or not is judged on the basis of the real-time temperature difference between the perfusate temperature Tin of a liquid inlet pipeline and the perfusate temperature Tout of a liquid discharging pipeline, and when the real-time temperature difference exceeds a temperature rise threshold value, temperature control intervention is started; the perfusate temperature control module is controlled by the temperature control unit to heat the perfusate, so that the bladder is accelerated to rise to a stable state, perfusion is performed at a dynamic temperature, the duration of the bladder in a low-temperature environment is shortened, and the probability of contraction and spasm of smooth muscles of the bladder can be effectively reduced.

The invention discloses a traditional Chinese medicine composition for treating breast cancer and a preparation and application thereof, and belongs to the technical field of traditional Chinese medicine and network pharmacology. The traditional Chinese medicine composition comprises the following raw material medicines: radix bupleuri, angelica sinensis, radix paeoniae alba, radix curcumae, dandelion, uniflower swisscentaury root, sculellaria barbata, selfheal, rhizoma bolbostemmae, thunberg fritillary bulb, spina gleditsiae, turtle shell, salvia miltiorrhiza and glossy privet fruit. The main effective components of the traditional Chinese medicine composition are quercetin, luteolin, kaempferol, beta-sitosterol and the like, and can participate in conduction of Hippo, TGF-beta, axon guidance, tight junction, vascular smooth muscle contraction and other signal channels through PTGS2, PTGS1, NCOA2, ADRB2 and other targets. Further, the anti-tumor effect is achieved in the biological processes of positively regulating cell growth, negatively regulating and controlling an external apoptosis signal path through a death structural domain receptor, positively regulating an endothelial cell apoptosis process, reaction to cytokines, an internal apoptosis signal path, a hormone-mediated signal transduction path and the like.

Substituted [benzo[f]imidazo[1,5-a][1,4]diazepine]-3-carboxylic acid compounds are GABA(A) receptor modulators and have utility to treat inflammation and / or inhibit smooth muscle contraction.