15 results about "Free form" patented technology

Provided are a salt of an arylaminoquinazoline-containing compound as shown in formula 2, a solvate or hydrate thereof, a preparation method therefor and the use thereof. The prepared salt has good crystallinity, and compared to a compound in a free form, the water solubility is significantly improved, and preferably, the salt form and crystal form can stably exist. Therefore, compared to a compound in a free form or other salts, the salt has better druggability.

The design of numerals, letters and more by modular lines and dots relates to the possibility of creating physically or on digital environment numerals, letters or other free form features obtained by this concept.

A crystal of 7-((3R,5S)-1-acryloyl-5-methylpyrrolidin-3-yl)-4-amino-6-(cyclopropylethynyl)-N—((R)-1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide (compound (I)), and a crystal thereof with an acid (salt crystal or co-crystal) are provided.There are provided: a type II crystal of compound (I) with fumaric acid, having characteristic peaks at three or more diffraction angles (2θ±0.2°) selected from 5.5°, 6.8°, 9.3°, 13.4°, 15.3°, 16.3°, 18.5°, 19.8°, 22.0°, and 24.5° in a powder X-ray diffraction spectrum;a (free-form) type II crystal of compound (I) having characteristic peaks at three or more diffraction angles selected from 8.3°, 14.8°, 17.3°, 18.0°, 19.1°, 20.3°, 21.0°, 22.5°, 23.0°, and 26.2° in a powder X-ray diffraction spectrum;a (free-form) type I crystal of compound (I) having characteristic peaks at three or more diffraction angles selected from 9.9°, 11.7°, 13.2°, 17.7°, 18.1°, 18.8°, and 20.8° in a powder X-ray diffraction spectrum;a type V crystal of compound (I) with fumaric acid, having characteristic peaks at four or more diffraction angles selected from 6.9°, 9.4°, 10.2°, 13.7°, 21.1°, 23.6°, and 26.5° in a powder X-ray diffraction spectrum; anda type I crystal of compound (I) with fumaric acid, having characteristic peaks at four or more diffraction angles selected from 6.4°, 10.3°, 12.8°, 15.0°, 20.7°, 23.4°, and 26.6° in a powder X-ray diffraction spectrum.

The invention belongs to the technical field of concrete construction engineering, and particularly relates to a stress formwork-removal-free structure for forming a frame beam or column and a construction technology. The structure comprises a non-dismantling formwork and a buckle plate, the non-dismantling formwork is of a rectangular frame structure with an opening in one side, a plurality of embedded grooves penetrating in the length direction are formed in the three side faces of the non-dismantling formwork and the buckle plate, and the embedded grooves protrude out of the inner surface of the non-dismantling formwork; when the non-dismantling formwork is independently used, the non-dismantling formwork is a frame beam formwork and is used for forming a frame beam; the buckle plate is buckled to the opening side of the non-dismantling formwork to form a frame column formwork used for forming a frame column. The embedded groove is used for being meshed with concrete to form bond stress, so that the non-dismantling formwork, the buckle plate and the concrete form an integral stress component. Through the design of the embedded groove, reliable bond stress is formed between the non-dismantling formwork and concrete, the non-dismantling formwork and the concrete jointly form an overall stress component, all or part of steel bars can be replaced, the using amount of the steel bars is reduced, and the engineering cost is reduced.

The utility model discloses a form-removal-free constructional column PC part, which relates to the technical field of building construction and comprises a prefabricated PC part, reinforcing materials are arranged at four corners outside the prefabricated PC part, adjustable reinforcing sections are arranged on the periphery of the reinforcing materials, each adjustable reinforcing section comprises an upper reinforcing part and a lower reinforcing part, and the upper reinforcing part and the lower reinforcing part are connected through a connecting rod. The upper reinforcing part and the lower reinforcing part are arranged in an up-down crossed mode, an upper bolt groove is formed in one end of the upper reinforcing part, a lower bolt groove is formed in one end of the lower reinforcing part, and an adjusting bolt is arranged between the upper reinforcing part and the lower reinforcing part; the two upper reinforcing parts and the two lower reinforcing parts are symmetrically placed at the front end, the rear end, the left end and the right end of the reinforcing material respectively, the upper reinforcing parts and the lower reinforcing parts are vertically crossed, the adjusting bolts are rotated to slide in the upper bolt groove and the lower bolt groove, and therefore the distance between the upper reinforcing parts and the lower reinforcing parts is adjusted. And the requirements of constructional columns with different sizes are met.

The invention relates to the technical field of casting forming, in particular to a shape follow-up loose piece movement mechanism without an execution element. The die comprises an upper die assembly and a lower die assembly. The upper die assembly and the lower die assembly are assembled to form a cavity for casting production; the upper die assembly is provided with a mounting groove for mounting the shape follow-up loose piece; the shape follow-up movable block is inserted into the mounting groove in the horizontal direction, and the left and right end faces of the shape follow-up movable block are flush with the left and right end faces of the upper die assembly; a guide block matched with the shape follow-up movable block is arranged on the lower die assembly, and an inclined transmission slope is arranged on the guide block; in the mold closing process of the upper mold and the lower mold, the shape follow-up movable block moves back and forth in the horizontal direction along the transmission inclined surface and reaches a preset position; and during mold opening, the shape follow-up movable block realizes reverse resetting through the transmission inclined surface of the guide block, so that the demolding work is completed. According to the movable block driving device, movable block driving is achieved through movement of the mold, extra installation space is not needed, the space is saved, the movement precision is greatly improved, and therefore high-quality forming of casting products is guaranteed.

The disclosed technology relates to an artificial rock formation designed to resemble natural sand, coral, and sediment reef rock, composed of bonded aggregate mix particles. The aggregate mix consists of sand, crushed coral, crushed seashells, rock fragments, or a combination thereof, which are bonded together into larger shapes using a bonding agent, while maintaining a visible granular structure. The resulting formation exhibits a free-form or naturally irregular surface, determined in general by the spray pattern and by the fact that some particles are not fully encapsulated by the bonding agent. The artificial rock does not require large structural components for stability and retains the natural appearance of its constituent materials without visibly encapsulating a bonding layer. The final product may be used for aquariums, decorative applications, ensuring a realistic texture and structure suitable for various ecological and ornamental uses.

The utility model discloses an assembly type formwork-free formwork column, which belongs to the technical field of formwork columns, and comprises a plurality of formwork column bodies, the bottom surface of the lowest formwork column body is fixedly connected with a bottom plate, two adjacent formwork column bodies are connected through bolts, and the bottom plate is connected with a mounting component; the formwork column bodies are connected together through the bolts, the connecting mode is simple, convenient and efficient, reliability and stability are improved, due to the sectional type design, when the formwork column bodies are locally damaged or need to be maintained, the whole formwork column does not need to be treated, only damaged column sections need to be detached and replaced, and the formwork column is convenient to use. The formwork column is simple in structure, the maintenance cost and difficulty are reduced, the formwork column can adapt to the ground with different flatness and levelness by adjusting the installation assembly, and firm and reliable connection between the column and the ground can be ensured by adjusting the position of the installation hole in some construction sites with complex ground conditions.

The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The present invention relates to a de novo designed enzyme having alpha-1, 4- fucosyltransferase activity on the N-acetylglucosamine (GIcNAc) residue of Gal-β1,3-GlcNAc (lacto-N- biose, LNB), wherein said LNB resides in free form and / or is part of a saccharide. The present invention also relates to a de novo designed enzyme having alpha-1, 3-fucosyltransferase activity on the glucose (Glc) residue of Gal-β1,4-Glc (lactose). The present invention further relates to methods for the production of a fucosylated compound comprising Gal-β1,3-[Fuc-al,4]-GlcNAc and / or for the production of 3-fucosyllactose (3-FL, Gal-β1,4-[Fuc-al,3]-Glc). The present invention also provides a cell for expression of a de novo designed enzyme having alpha-1, 4-fucosyltransferase activity on the GIcNAc residue of LNB, wherein said LNB resides in free form and / or is part of a saccharide. The present invention also provides a cell for expression of a de novo designed enzyme having alpha-1, 3-fucosyltransferase activity on the Glc residue of lactose. The present invention further relates to a cell for production of a fucosylated compound comprising Gal-β1,3-[Fuc-al,4]-GlcNAc. The present invention further relates to a cell for production of 3-FL. The present invention also relates to the use of said cells in a cultivation or incubation.

The invention relates to an assembly type farm house and an on-site full-formwork-free construction method thereof, belongs to the technical field of farm house construction, and solves the problems of low efficiency, poor quality or high cost caused by a formwork cast-in-place procedure in traditional farm house construction in the prior art, or the problem of potential safety hazards or high cost existing in heating of an existing farm house. The fabricated rural house is provided with at least one layer and comprises an outer bearing wall, an inner bearing wall and constructional columns which are all of on-site full-formwork-free construction. The inner load-bearing wall is arranged in a space defined by the outer load-bearing walls, and window holes are formed in the two parallel outer load-bearing walls; the constructional columns are arranged at the ends of the outer bearing walls, the connecting portions of the outer bearing walls and the inner bearing walls, the corners of the space defined by the outer bearing walls and the two sides of the window opening. According to the method, on-site full-mold-free building is achieved, the construction efficiency is improved, part of components are prefabricated firstly and then subjected to on-site full-mold-free cast-in-place, the on-site construction quality is improved, and the construction cost is reduced.

A method is provided for deriving a surface profile of a free-form master lens for patterning one or two photo-alignment layers of a planar optical component. The method includes obtaining a desired optical function of the planar optical component; and obtaining an actual optical function of the planar optical component, the actual optical function being described as recorded using a free-form test lens with a surface profile configured to provide the desired optical function. The method includes estimating a deviation between the desired optical function and the actual optical function; and correcting the surface profile of the free-form test lens using the estimated deviation, thereby deriving a surface profile for the free-form master lens.

1. The name of the design product: tool (free to support the pipeline hole bracket). 2. The use of the design product: for building vertical stand pipe hole plugging. 3. The design features of the design product: in shape. 4. The picture or photo that best indicates the design features: perspective view 1.

A system and method for designing and manufacturing free-form objects made of composite material and optimised in their weight ratio and load capacity; a system for the design and manufacture of said objects, and the objects resulting from said method. Using three-dimensional (3D) design computer programs and computer calculation programs, the design of a composite material object is obtained, with a specific shape and orientation of its component fragments, optimised to be light and at the same time to meet a required specific mechanical and / or structural performance. Subsequently, a mould of at least two parts is obtained from this design and the parameters of said design are transformed into instructions so that one or more automated manufacturing machines deposit fragments of wood or another material onto the lower part of the mould in specific orientations, calculated to minimise the weight of the object and optimise its load capacity. Then, with the addition of one or more binders, the object is pressed between the parts of said mould. Finally, the new manufactured object is obtained by removing it from the mould.

The present invention provides a liquid composition that can suppress the excessive amount of 3-hydroxybutyric acid, even when it is present. [Solution] A liquid composition is prepared containing 3-hydroxybutyric acid, a salt of 3-hydroxybutyric acid, and water. The proportion of the salt of 3-hydroxybutyric acid may be 0.1 to 100 moles per 100 moles of 3-hydroxybutyric acid. The total proportion of 3-hydroxybutyric acid and the salt of 3-hydroxybutyric acid may be 15% by mass or more in the liquid composition, in terms of 3-hydroxybutyric acid in its free form. The 3-hydroxybutyric acid may be R-3-hydroxybutyric acid produced by fermentation using microorganisms. The pH of the liquid composition may be 2.2 or higher. The liquid composition may be a beverage or its concentrate.