2541 results about "Hydrate" patented technology

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The present disclosure provides crystalline forms, solvates and hydrates of (R)-5-fluoro-2-methyl-1-((R)-5-(pyridin-2-yl)-2,3-dihy dro-lH-indene-2-carbonyl)indoline-6- sulfonamide, and methods of making.

Provided herein, in part, is a compound of Formula (I)or a hydrate thereof,essentially free of one or more impurities, compositions thereof, and methods of use thereof.

Provided herein are new crystalline form of the compound of formula (A), which is a hydrate, and its pharmaceutical composition and use of the same in treating cancer.

Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.

To provide an environmental test apparatus capable of performing a long-term deterioration test in which a test sample is exposed for a long period to methane-dissolved water under a low-temperature, high-pressure environment simulating a seafloor environment.SOLUTION: An environmental test apparatus 100 according to an embodiment is an environmental test apparatus for performing a long-term deterioration test in which a test sample is exposed to methane-dissolved water under an environment simulating a seafloor environment where methane hydrate is present and includes: a pressure-resistant vessel 110 which houses the test sample and in which the methane-dissolved water at a temperature and pressure corresponding to the seafloor environment flows through the test sample; a cooling unit 120 that cools and maintains the pressure-resistant vessel 110 at the temperature; and a pressurizing circulation unit 130 that pressurizes the methane-dissolved water flowing out from an outlet 110b of the pressure-resistant vessel 110 and sends it toward an inlet 110a of the pressure-resistant vessel 110.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of heating bodies, and particularly relates to a method for preparing a sheet-shaped heating body. The preparation method comprises the following steps: stirring and dissolving lanthanum nitrate, strontium nitrate, manganese nitrate hexahydrate and a solvent to obtain a metal salt solution; preparing the metal salt solution into a precursor, wherein the precursor is a precursor solution or precursor sol; and carrying out tape casting and drying on the precursor to obtain a biscuit sheet, and carrying out glue removal treatment and sintering on the biscuit sheet to obtain the sheet-shaped heating body. According to the preparation method, a precursor system is optimized, the dispersion stability of the precursor is improved, casting, drying and sintering processes are matched, the problem of powder agglomeration is solved, the defects of green bodies are reduced, the drying shrinkage rate of green body pieces in the preparation process is reduced, the surface roughness is reduced, the stability and heat output uniformity of a heating body are improved, and the compactness is improved.

The present invention discloses a method for preparing highly dispersible submicron spherical palladium powder. The method comprises the following steps: first, weighing solid palladium nitrate and dissolving it in dilute nitric acid to prepare a dilute palladium nitrate solution; then dissolving a reducing agent in deionized water to obtain a reducing solution; then weighing a dispersant and an additive and dissolving them in deionized water to obtain a mixed base solution; and then mixing the three to obtain a reaction slurry containing palladium powder. The mixture is then filtered, washed, and dried to obtain submicron spherical palladium powder particles. The present invention adopts a liquid phase reduction method to reduce the palladium nitrate solution with ascorbic acid or hydrazine hydrate as a reducing agent to prepare the submicron spherical palladium powder. An organic polymer dispersant and a small molecule alcohol additive are simultaneously added to the base solution in a symmetrical manner. While ensuring the yield of palladium powder, the particle growth process and dispersibility are well controlled. The prepared palladium powder particles are spherical and highly dispersed, with a particle size of 100 to 600 nm.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention discloses a hydrate-containing porous medium resistivity model construction method considering hydrate heterogeneous distribution, and the method comprises the following steps: 1) manufacturing a rock core according to the rock composition of a target hydrate reservoir, and scanning the pore throat structure of the rock core through CT; 2) generating a hydrate in the core, and scanning the occurrence state of the hydrate through CT (Computed Tomography); 3) establishing a digital core model based on CT scanning data, and applying an electrostatic field; 4) changing hydrate saturation parameters in the model, and calculating the resistivity of the model through numerical simulation; 5) calculating the critical water saturation of the hydrate; and (6) fitting by taking the critical water saturation as a boundary to obtain a resistivity segmentation calculation model. According to the method, a hydrate-containing porous medium resistivity model is established based on a real rock core size, and an electric field simulation means is utilized to calculate a hydrate-containing porous medium resistivity value. In combination with CT scanning data, an undetermined coefficient of a porous medium resistivity calculation formula in a hydrate thermal decomposition experiment is obtained through electric field simulation, and a basis is provided for hydrate reservoir electric heating development.

The invention provides a fluidization two-field coupled natural gas hydrate exploitation simulation method and system, and relates to the field of natural gas hydrate exploitation. A fluidization two-field coupled natural gas hydrate exploitation simulation method comprises the following steps: establishing a geometric model of a natural gas hydrate reservoir on the basis of reservoir parameters and physical parameters of the natural gas hydrate reservoir; based on a mass conservation equation, establishing a control equation set of the natural gas hydrate fluidization two-field coupling model; adjusting the control equation set based on the intrinsic dynamic behavior of the natural gas hydrate phase change decomposition and the two-phase seepage law of the natural gas hydrate to obtain a target control equation set; based on initial conditions and boundary conditions, solving the target control equation set to obtain two-phase seepage field and chemical decomposition field distribution; based on the distribution of the two-phase seepage field and the chemical decomposition field, calculating the accumulated decomposition, water production and gas production quality of the natural gas hydrate. Therefore, simulation accuracy can be improved, and engineering practicability is facilitated.

The invention relates to the technical field of metal material hot working, and discloses a hot-rolled coiled plate production process which comprises the following steps: preparing a reaction type protective agent, the high-temperature-resistant coating is prepared from the following raw materials in parts by weight: 20 to 40 parts of tetraethoxysilane, 5 to 15 parts of triethyl phosphate, 1 to 5 parts of triethyl borate, 0.5 to 2.0 parts of cerous nitrate (III) hexahydrate, 0.1 to 1.0 part of lithium acetate and 0.01 to 0.05 part of vanadyl acetylacetonate (IV). Coating the surface of a hot-rolled plate blank with the protective agent; the coated plate blank is heated in a heating furnace, so that the protective agent forms a molten-state protective layer in situ; carrying out hot rolling on the plate blank with the molten protective layer; and cooling and coiling the hot-rolled steel strip. In the whole heating and hot rolling process, the molten protective layer isolates the contact between the steel and the oxidizing atmosphere, so that the generation of oxide scales is fundamentally inhibited, the production process is simplified, and the metal yield is increased.

The invention discloses a preparation method of pyridinetriazolone, and belongs to the technical field of organic synthesis, and the preparation method comprises the following steps: taking hydrazine hydrate as a starting raw material, adding urea in batches at the temperature of 80-85 DEG C, carrying out heat preservation reaction to obtain semicarbazide, dropwise adding hydrochloric acid to form salt, and drying under reduced pressure to obtain semicarbazide hydrochloride; adding the semicarbazide hydrochloride obtained in the previous step and 2-chloropyridine into an ethylene glycol monomethyl ether system, heating to 130-135 DEG C, refluxing, adding a catalytic amount of concentrated sulfuric acid, and carrying out heat preservation reaction to obtain pyridine triazolone; and drying the post-treated mother liquor under reduced pressure, weighing, adding quantitative urea, heating to 130-135 DEG C, and reacting to obtain the pyridinium triazolone. The initial raw materials are hydrazine hydrate and urea, are common industrial raw materials, are easy to obtain and low in price, and are beneficial to industrial production; the by-product 2-hydrazinopyridine is recovered and reacts with urea to prepare the pyridintriazolone, so that the raw material utilization rate and the product yield are greatly improved, the total yield reaches more than 80%, and the purity of the pyridintriazolone is more than or equal to 99.0%.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The present invention discloses a preparation method and application of a Bi2O2S / Bi 12 TiO 20 composite photocatalytic material, which includes weighing Bi2O3 and titanium dioxide, grinding them evenly, putting them into a muffle furnace, heating to 700 °C, maintaining the temperature for 6 - 8 h, and then naturally cooling to room temperature to obtain Bi 12 TiO 20 catalyst; dispersing Bi 12 TiO 20 in deionized water, adding a hydrazine hydrate solution of thiourea, stirring, adding KOH and NaOH, stirring well, standing, centrifuging, washing the centrifuged product alternately with water and ethanol, and drying to obtain Bi2O2S / Bi 12 TiO 20 composite photocatalyst. The present invention adopts the normal temperature standing method, and the energy consumption during the synthesis process is low; the Bi2O2S / Bi 12 TiO 20 composite material is a block-coupled sheet combination structure, and the combination of the two materials can greatly improve the separation efficiency of electron-hole pairs and has excellent performance in photocatalytic degradation of 2,4-dichlorophenol.

The present invention provides a manganese metal-organic framework material with oxidase properties, a preparation method, and an application thereof. The material is prepared by the following method: using 1,3,5-trimethic acid as an organic ligand, manganese acetate tetrahydrate as a manganese source, and a water-ethanol solution as a solvent, to obtain a manganese metal organic framework (MOF) precursor via a solvothermal synthesis technique; the manganese MOF precursor is post-synthetically modified using an oxidant, wherein the oxidant is a mixed solution of an aqueous alkali metal hydroxide solution and H2O2, and the ratio of the manganese MOF precursor to the alkali metal hydroxide is (400-600) mg:(0.5-2) mmol. By using specific types and amounts of manganese MOF precursors and oxidants, the resulting metal-organic framework nanomaterial has specific enzyme-like properties, can exert the function of uricase, and has optimal and high uricase activity under neutral pH conditions.

The invention belongs to the technical field of nano composite materials, and discloses a novel transition metal-inserted transition metal sulfide composite rare earth oxide photocatalytic material with a solid mediator Z-type heterostructure, and a preparation method and application of the novel transition metal-inserted transition metal sulfide composite rare earth oxide photocatalytic material. The preparation method comprises the following steps: mixing transition metal salt, thioacetamide, nitrate hexahydrate and water to obtain a mixed solution 1; mixing the mixed solution 1 with a hydrazine hydrate solution, and performing hydrothermal reaction to obtain a mixed solution 2; mixing the mixed solution 2 with ammonia water, and sequentially carrying out hydrothermal reaction, drying and calcining to obtain a calcined product; and mixing the calcined product with a sodium borohydride aqueous solution, and drying to obtain the photocatalytic material. The obtained photocatalytic material of the transition metal inserted transition metal sulfide composite rare earth oxide with the solid mediator Z-type body heterostructure has the characteristics of high stability, safe interface contact and rapid charge migration.

The present invention relates to an activator for cementless binders comprising: a silicate of an alkali metal or alkaline earth metal or a hydrate thereof; a carbonate of an alkali metal or alkaline earth metal or a hydrate thereof; and a hydroxide of an alkali metal or alkaline earth metal or a hydrate thereof. The invention also relates to a cementless binder comprising said activator and to a cementless cementitious material comprising said cementless binder. Compared with the traditional ordinary Portland cement, the building material containing the cement-based cementing material has better compressive strength and has the characteristic of environmental protection.

The invention discloses an aluminum alloy surface and a treatment method thereof, and relates to the technical field of aluminum alloy surface treatment.The treatment method comprises the steps that the surface of an aluminum alloy is cleaned, subjected to chemical pretreatment, subjected to pulse anodic oxidation and then subjected to sealing treatment; an electrolyte used for anodic oxidation comprises the following components in percentage by mass: 10%-30% of sulfuric acid, 0.5%-1% of tea polyphenol, 0.1%-0.3% of cerous nitrate and 0.2%-0.5% of nano aluminum oxide; the confining liquid for confining is prepared from the following components in percentage by mass: 0.5 to 1 percent of chitosan particles, 0.2 to 0.5 percent of nano zinc oxide and 0.1 to 0.3 percent of cerium complex; wherein the cerium complex is cerium oxalate or cerium acetylacetonate hydrate. According to the aluminum alloy surface treatment method, the surface of the aluminum alloy matrix contains the pulse oxide layer and the closed film layer, and the formed aluminum alloy surface has good mechanical performance, insulating performance and anti-aging performance.

The present invention generally relates to a process for fabricating a reduced graphene oxide (rGO)-based antifouling marine coating is disclosed. The process begins with preparing a dispersed graphene oxide solution, followed by chemical reduction using hydrazine hydrate at 90-95° C. for 3 hours to form a dispersed rGO solution. This solution is then washed, filtered, and sonicated for 6 hours to ensure stability. A polymer solution is prepared by dissolving 40-50 wt % epoxy resin in acetone at 50° C. The antifouling composite is then formed by combining the rGO solution, 10-15 wt % zinc oxide nanoparticles, and 1-5 wt % carbon nanotubes with the polymer solution, followed by 6 hours of sonication at room temperature. Finally, the resulting composite material is applied to a substrate as a coating using spraying, brushing, dipping, or spin coating. This coating offers a promising solution for preventing biofouling on marine structures.

An experimental apparatus for planar interfacial shear of a hydrate-bearing sediment includes a planar interfacial shear box, a torsional and axial loading device, a nitrogen gas source, a methane gas source, a pressure-volume controller, a water bath device, a back pressure valve, a gas-water separator, a gas flowmeter, and a data acquisition system. The planar interfacial shear box includes an upper pressing plate, an upper adapter, an upper thermal insulation plate, a ram adapter, a lower ram, an upper base, a lower base, a lower thermal insulation plate, a lower adapter, and a lower pressing plate that are coaxially connected in sequence from top to bottom. The experimental apparatus offers a simple specimen preparation method, enabling in-situ formation of a hydrate-bearing sediment in the shear box. The experimental apparatus ensures uniform stress distribution during shearing, and can acquire the interfacial shear mechanical characteristic between the hydrate-bearing sediment and a structure.

The invention relates to the technical field of oil and gas resource exploration and deep coal and rock gas development, in particular to a wellbore unblocking method based on hydrate impact by carbon dioxide phase change, which comprises the following steps: S1, collecting well pipe column data of a wellbore completely blocked by hydrate, and measuring the depth, temperature and pressure of the hydrate; s2, prefabricating a carbon dioxide phase change impact scheme: according to the size of an oil pipe, the strength of the oil pipe, the depth of hydrate and the pressure and temperature of a shaft above the hydrate, the length and weight of a carbon dioxide phase change device used for the operation of the well to be unblocked and the amount of liquid carbon dioxide are formulated; and S3, the carbon dioxide phase change device is put into the well. The carbon dioxide phase change impact hydrate wellbore unblocking method can be applied to wells with wellbores completely blocked by hydrates and without flow channels, has the advantages of being easy and convenient to operate, large in impact force and high in unblocking efficiency, and solves the problem that when the wellbores are completely blocked by the hydrates and no flow channels exist, the unblocking difficulty is large.

The invention relates to the technical field of semiconductor gas sensors for gas detection, in particular to an in-situ construction method and application of a gas sensor for volatile aroma substance detection, and the in-situ construction method comprises the following steps: mixing an aqueous solution of zinc nitrate hexahydrate and an aqueous solution of 2-methylimidazole according to different molar ratios to obtain a precursor solution; upwards fixing a planar electrode on the surface of a glass slide, and then transferring the planar electrode into the precursor solution; carrying out hydrothermal reaction on the precursor solution at 90 DEG C for 4 hours, after the hydrothermal reaction is finished, cooling to normal temperature, taking out the glass slide, washing the surface of an electrode by using deionized water, removing impurities, and then carrying out drying treatment; calcining the obtained dried electrode in an air atmosphere at 500 DEG C for 2 hours to construct an in-situ growth semiconductor sensor; according to the present invention, the rapid sensing response on nine volatile aroma substances is achieved, and the excellent gas sensitive characteristic is represented in the gas sensitive research on the volatile substance ocimene in the volatile aroma substances.

The present disclosure relates to novel lamotrigine salts, co-crystals, and compositions. In some embodiments, the lamotrigine salt is a lamotrigine dicarboxylic acid salt or hydrate or solvate thereof. In some embodiments, the lamotrigine co-crystal is a co-crystal of lamotrigine and a dicarboxylic acid, or a hydrate or solvate thereof. In some embodiments, the compositions comprise lamotrigine or a salt or co-crystal thereof, or a hydrate or solvate thereof. In some embodiments, the composition is in the form of a powder. In some embodiments, the composition is in the form of a liquid. The present disclosure also relates to methods of preparation and use in medical therapy, for example, for the treatment of a subject with epilepsy or bipolar disorder.

The invention discloses a preparation method of a composite flocculant based on efficient water treatment, belongs to the technical field of flocculant processing, and aims to solve the technical problem that the flocculation performance and the settling performance of a flocculant need to be further improved in the prior art. The preparation method specifically comprises the following steps: putting acrylamide, diallyldimethylammonium chloride, 2-hydroxypropyl methacrylate and deionized water into a reaction kettle, and uniformly mixing to obtain a mixed monomer; according to the preparation method, citric acid monohydrate and iron nitrate nonahydrate react under a mild acidic condition to form a Fe < 3 + >-citric acid complex, and then 2-hydroxyethylamine is introduced to further participate in complexing to obtain a citric acid complexing solution, so that not only is the flocculation performance of the composite flocculant improved, but also the settling performance of the composite flocculant is improved.

The invention relates to the technical field of gas hydrate phase equilibrium tests, in particular to a gas hydrate phase equilibrium condition testing device and method under the normal pressure condition, and the testing device adopts a core framework integrating hydrate synthesis and phase equilibrium testing under the normal pressure into the same reaction kettle unit. And aiming at the functional difference of phase balance test under synthesis and normal pressure, independent high and low temperature control subsystems and pressure control modules are respectively arranged, so that the efficiency of a high-pressure synthesis stage is guaranteed, and the precision requirement of a low-pressure test stage is met. According to the testing method, a constant-volume gradual heating decomposition method is adopted, high-precision micro-pressure change monitoring is combined, and the phase equilibrium point of the hydrate under the low-pressure condition can be accurately captured. The problem that hydrate phase equilibrium experiment data in the area near the normal pressure is deficient is solved, and key data support can be provided for model verification and safety design.

The invention provides a method and a device for testing nano-mechanical properties of a hydrate cementation surface, and relates to the technical field of hydrate micromechanics, a sand particle sample is arranged in a reaction kettle in advance, ice is preferentially generated in the reaction kettle by using an ice seed method, then guest molecules are injected, and the temperature is controlled to circulate near phase equilibrium so as to form a hydrate; hydrate-sand particles are constructed to form three different contact forms, the tops of part of the particles are exposed out of the upper surface of the hydrate, the tops of part of the particles are tangent to the upper surface of the hydrate, and part of the particles are completely wrapped by the hydrate so as to simulate the actual contact state of the hydrate and the sand particles in an underground reservoir; the method is used for measuring nano mechanical properties such as hardness, elastic modulus and creep property of the hydrate cementation interface. The device has the beneficial effects that the influence of different factors on the mechanical strength of the hydrate cementation interface is disclosed, and the direct test of the mechanical strength of the microcosmic hydrate-sand particle cementation interface is realized.

The invention provides a compound hydrate inhibitor and a natural gas consumption prediction device and method, the compound hydrate inhibitor comprises a kinetic hydrate inhibitor, a thermodynamic hydrate inhibitor and 900-1000 parts of solvent water, the kinetic hydrate inhibitor comprises 5-20 parts by weight of polyvinylpyrrolidone, the thermodynamic hydrate inhibitor comprises 10-20 parts by weight of polyvinylpyrrolidone, and the solvent water comprises 10-20 parts by weight of a solvent. The thermodynamic hydrate inhibitor is prepared from 19 to 38 parts of monohydric alcohol compound and 15 to 20 parts of soluble chlorine salt. The hydrate inhibitor has a remarkable inhibition effect on a hydrate nucleation stage, after polyvinylpyrrolidone, methyl alcohol and sodium chloride are mixed, the inhibition effect of the hydrate can be synergistically improved, the compound hydrate inhibitor is applied to a natural gas consumption prediction device, and the natural gas consumption prediction efficiency is improved. Generation of natural gas hydrate in the pipeline conveying process of natural gas can be further simulated, and more accurate natural gas consumption prediction can be carried out on an untested formula or according to actual natural gas conveying conditions.