525 results about "Amidine" patented technology

The present invention is concerned with new compounds, and particularly those having a fused bicyclic ring substituted with an amidine moiety. These compounds are each potent inhibitors of Factor D of the alternate pathway of complement, C1s of the classical pathway of complement, Factors Xa, XIIa, VIIa and thrombin of the coagulation pathway, plasmin in the fibrinolytic pathway, and kallikrein and high molecular weight kininogen in the inflammatory pathways. These proteases, which have serine in their active site, are called serine proteases and they are pivotal to most of the processes of inflammation and coagulation. In fact, these various systems are interactive with one another and it is difficult to activate one pathway without it influencing the others.

The present invention is directed to novel organometallic complexes as catalysts for the reaction of compounds with isocyanate and hydroxyl functional groups to form urethane and / or polyurethane and the process employing such catalysts. More particularly, the present invention is directed to novel complexes of zinc(II) with substituted amidines. These novel catalysts are useful for the production of urethanes and polyurethanes which are important in many industrial applications.

A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO2, is described. In preferred embodiments, the ionic solvent is readily converted back to the nonionic liquid mixture. The nonionic liquid mixture includes an amidine or guanidine or both, and water, alcohol, or a combination thereof. Single component amine solvents that reversibly convert between ionic and non-ionic states are also described. Some embodiments require increased pressure to convert; others convert at 1 atmosphere.

Compositions comprising a fluoropolymer having interpolymerized units derived from a nitrogen-containing cure site monomer and an amidine-containing curative are provided.Also provided are a method of making a fluoropolymer and fluoropolymer articles containing curable or cured fluoropolymer compositions.

Reversible switchable surfactants are provided. A surfactant is the salt of an amidine or guanidine having at least one R group that is a hydrophobic moiety selected from the group consisting of higher aliphatic moiety, higher siloxyl moiety, higher aliphatic / siloxyl moiety, aliphatic / aryl moiety, siloxyl / aryl moiety, and aliphatic / siloxyl / aryl moiety. The other R groups are smaller moieties such as H, C1 to C4 aliphatic or the like. The surfactant is turned on by a gas that liberates hydrogen ions, such as, for example, carbon dioxide, which liberates hydrogen ions in the presence of water. The surfactant is turned off by exposure to a flushing gas and / or heating. When “on” the surfactants are useful to stabilize emulsions, and when “off” they are useful to separate immiscible liquids or a liquid and a solid. The surfactants find uses in polymerization and in the oil industry.

The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates via the direct reaction of nitric oxide with amidines and enamines, and to a method of converting amines into such compounds.

A coating composition for pre-treating a substrate prior to inkjet printing thereon, and an inkjet receiving medium comprising a substrate and having a topmost layer coated thereon, where the coating composition and topmost layer comprise one or more aqueous-soluble salts of multivalent metal cations, a cationic polyelectrolyte comprising amidine moieties, and one or more second polymer which is distinct from the cationic polyelectrolyte and which is selected from the group consisting of a polyamide-epichlorohydrin, a polyamine solution polymer, and a waterborne or water-dispersible polyurethane. The topmost layer is advantageously at a solid content of from 0.1 to 5 g / m2, and comprises from 30-90 wt % of the one or more aqueous soluble salts of multivalent metal cations, at least 0.01 g / m2 of the cationic polyelectrolyte comprising amidine moieties, and at least 0.005 g / m2 of the second polymer which is distinct from the cationic polyelectrolyte comprising amidine moieties.

The present invention relates to nitric oxide-releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines.

There is a tin-free curable composition having (A) one or more organic polymers having a reactive-silicon-containing group, wherein at least one polymer has a main chain skeleton selected from the group consisting of polyoxyalkylene polymers, saturated hydrocarbon polymers, and (meth)acrylic acid ester polymers; (B) from 0.001 to 20 parts by weight for 100 parts by weight of the organic polymer(s) (A) of a silanol condensation catalyst consisting of one or more metal amidine complexes and one or more amine carboxylate salts, (C) a crosslinker or chain extender chosen from an alkoxysilane, an alkoxysiloxane, an oximosilane, an oximosiloxane, an epoxysilane, an epoxysiloxane, an aminosilane, a carboxysilane, a carboxysiloxane, an alkylamidosilane, an alkylamidosiloxane, an arylamidosilane, an arylamidosiloxane, an alkoxyaminosilane, an alkaryaminosiloxane, an alkoxycarbamatosilane, an alkoxycarbamatosiloxane, and combinations of two or more thereof; and (D) at least one adhesion promoter chosen from a silane or siloxane other than the compounds listed under (C). There is also a cured polymer formed from the tin-free curable composition.

Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

The invention relates to a composition comprising polymerizable material and an anionic photocatalyst. The photocatalyst is a photolabile compound able to liberate a strong base having a pK.sub.a .gtoreq.12. The catalyst can be illustrated by the structural formula Z-A wherein Z is a photolabile group and A is a strong base, for example, a nitrogen containing compound such as, a secondary amine, a guanidine or amidine and Z is covalently bound to A.

A method of treating a liquid. The method comprises providing a feed liquid comprising at least one solvent and at least one solute to a first side of a membrane. A single-phase draw solution comprising at least one of an aminium salt, an amidinium salt, and a guanidinium salt is provided to a second side of the membrane. The at least one solvent is osmosed across the membrane and into the single-phase draw solution to form a diluted single-phase draw solution. At least one of CO2, CS2, and COS is removed from the diluted single-phase draw solution to form a first multiple-phase solution comprising a first liquid phase comprising the at least one solvent, and a second liquid phase comprising at least one of an amine compound, an amidine compound, and a guanidine compound. A liquid purification system is also described.

The present invention has its object to provide a curable composition not containing any organotin type curing catalyst currently of concern because of the toxic feature thereof, or any volatile compound, excellent in curability and storage stability and, further, capable of providing cured products excellent in strength and elongation; the above object can be achieved by a curable composition which includes: an organic polymer (A) containing a hydrolyzable silyl group in a molecule; an amidine compound (B); and a compound (C) containing a sulfonyl group in a molecule.

The invention relates to the technique for purifying and producing industrial phosphoric acid by wet-process phosphoric acid, which comprises the following steps of: (1) desulfurization and defluorination sedimentation-filtration process; (2) the extraction of wet-process phosphoric acid after desulfurization and defluorination process; (3) the washing of organic phase after extraction; (4) the back extraction of the organic phase after washing; (5) the refining of aqueous phase after the back extraction; (6) concentrating till containing 85wt% H3PO4 and recycling organic solvent. The technique has the beneficial effects that (1) the wet-process phosphoric acid produced by adopting the existing sulfuric acid process does need to be preconcentrated; (2) compound extracting agent of the technique has good suitability for the extraction of the wet-process phosphoric acid; (3) the compound extracting agent has better separating effect on iron ions and other heavy metal ions; (4) emulsion generated by the organic phase in the washing process can be eliminated by a warming / stewing mode; (5) the technique adopts amidine fiber adsorption column to refine wet-process phosphoric acid and can effectively absorb trace metal ions, and the clearance of the metal ions can reach 99 wt%.

The present invention relates to cosmetic compositions containing an amidine, an alkane polyol having a ClogP of from +0.2 to +1.55 and water. The present invention also relates to methods of using such cosmetic compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.

This disclosure provides compounds of Formula I as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine diamide derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.

An object of the present invention is to provide a method for forming a multilayer coating film, capable of achieving excellent curability under low-temperature, short-time conditions, and forming a multilayer coating film having excellent chipping resistance and an excellent finished appearance. This method comprises sequentially applying an aqueous first colored coating composition (X), an aqueous second colored coating composition (Y), and a clear coating composition (Z) to a substrate, and simultaneously bake-curing the resulting multilayer coating film. In this method, the aqueous first colored coating composition (X) comprises an aqueous film-forming resin (A) and a specific blocked polyisocyanate compound (B), and the clear coating composition (Z) comprises a hydroxy-containing acrylic resin (K) having a hydroxy value in a specific range, a polyisocyanate compound (L), and an organometallic catalyst (M) containing a metal compound (M1) selected from a specific range and an amidine compound (M2).

The present invention is directed to novel organometallic complexes as catalysts for the reaction of compounds with isocyanate and hydroxyl functional groups to form urethane and / or polyurethane and the process employing such catalysts. More particularly, the present invention is directed to novel complexes of zinc(II) with substituted amidines. These novel catalysts are useful for the production of urethanes and polyurethanes which are important in many industrial applications.

The invention discloses a preparation method of polypeptide solid-phase synthesis bivalirudin crude product. The preparation method comprises the following steps of: (1) mixing Fmoc-amino-acid resin or Fmoc-polypeptide resin and an unprotecting agent and removing Fmoc protecting group; (2) in the existence of a condensing agent, leading amino acid with Fmoc or Boc and amino acid or polypeptide onthe resin to carry out condensation; (3) repeating the step (1) and step (2) and obtaining polypeptide resin shown as formula II; and (4) in the existence of a cutting agent, leading the polypeptide and the resin on the polypeptide resin to be separated, and obtaining bivalirudin shown as formula I. The unprotecting agent contains 3 to 20 percent of piperidine and 0.5 to 10 percent of bicyclic amidine by total volume.

A process for producing amidine derivatives represented by the following reaction scheme, characterized in that the reactions of steps 1 and 3 are conducted in acetonitrile and the reaction of step 2 is conducted in acetone. 1

The invention relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl C2-20 olefin in the presence of an ionic catalyst, comprising an organometallic compound and an activator, and optionally a scavenger, characterized in that the organometallic compound is a compound according to formula (1): where: M is a metal of group 3, 4, 5, 6 or 7, orthe lanthanide series, and p is the valency of the metal M, A represents a neutral or anionic spectator ligand whose valency v is 0, 1 or 2, and q is an integer denoting the number of spectator ligands A, Z is an optional bridging moiety, n is the integer number of parallel bridging moieties Z, Y is an amidine-containing spectator ligand represented by formula (2): wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, Sub1 is a substituent, which comprises a group 14 atom through which Sub1 is bonded to the imine carbon atom. Sub2 is a substituent, which comprises a heteroatom of group 15-16, through which Sub2 is bonded to the imine carbon atom, r is an integer > 0, L is an optional neutral Lewis basic ligand, j is an integer denoting the number of neutral ligands L, and X is an anionic ligand. The invention further relates to a organometallic compound according to formula (1) and a process for the preparation of this compound as well as to a UHMWPE having a weight average molecular weight of at least 4.000 kg / mol and a molecular weight distribution Mw / Mn of less than 2.6.

A curable composition comprises (a) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydrosilyl moiety; (b) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydroxysilyl moiety, the hydroxysilyl moiety optionally being generated in situ by hydrolysis of at least one hydrosilyl moiety; and (c) at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; with the proviso that, when component (a) is an organic polymer, then component (b) is different from component (a) and is not generated in situ by hydrolysis of component (a).

A dermatological composition for application to the skin or nails comprises a salt of a cation and an anion. The cation is derived from a monomeric or polymeric molecule that will generate an amidine moiety, a guanidine moiety or a biguanide moiety. The anion is derived from a monomeric or polymeric molecule that will generate a carboxylic acid moiety. The composition may be prepared by a metathesis or acid-base reaction.

The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

A method for preserving wood which comprises contacting the wood with a complex of a cationic monomeric or polymeric biocide and an anionic monomeric or polymeric biocide. Insoluble complexes may solubilized in water in the form of an emulsion or microemulsion by adding a nonionic and / or amphoteric surfactant and / or aqueous cosolvent to the complex. Suitable cationic biocides are those that contain functionalities such as amidine, guanidine, biguanide, quaternary, phosphonium, sulfonium and gemini quaternary functionalities. Suitable anionic biocides include: phenolics; saturated, unsaturated or substituted carboxylates; organomercaptide; tetrathiocarbonates; cyanodithioimidocarbamates; dithiodialkylcarbamates; anionic oxides of transition metals; aminocarboxylic acids; aminoorganophosphonic acids; monoalkyl phosphates; dialkylphosphates; and substituted or unsubstituted 2-hydroxy-2,4,6-cycloheptatrianone.

The present invention relates to novel beta-lactam compounds of formula (I), their preparation and use. In particular, this invention relates to novel beta-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.

The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

A curable composition comprises (a) at least one polyorganosiloxane, fluorinated polyorganosiloxane, or combination thereof comprising reactive silane functionality comprising at least two hydroxysilyl moieties; (b) at least one polyorganosiloxane, fluorinated polyorganosiloxane, or combination thereof comprising reactive silane functionality comprising at least two hydrosilyl moieties; and (c) a catalyst composition comprising (1) at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof, and (2) at least one Lewis acid; wherein at least one of the components (a) and (b) has an average reactive silane functionality of at least three.

The invention discloses an antimicrobial and antidandruff composition and application thereof. The composition comprises a pyrithione polyvalent metal salt and an alkoxy aromatic amidine compound, and preferably comprises zinc pyridine thione and hexamidine isethionate, wherein the weight ratio of the zinc pyridine thione to the hexamidine isethionate in the composition is 1:20-10000:1. The composition can be applied in washing-off systems such as liquid shampoos, hair conditioners, facial cleansers, dermatophytosis removal products or shower gel and the like which have the effects of sterilization and antibiosis. The antimicrobial and antidandruff composition can provide the high-efficiency effect of dandruff removal and sterilization, overcome the defect that the effects of dandruff removal, sterilization and itching relieving are not obvious due to the single use of any one component in the composition under the same condition, and play an excellent role in the dandruff removal, sterilization and itching relieving; and the zinc pyridine thione and the hexamidine isethionate have the synergic effect on the using effect, and the composition is used in products under the same using condition and using amount to reduce the amount used when only single component in the composition is used effectively, so the effects of the dandruff removal and itching relieving can be achieved.