156 results about "Amidine" patented technology

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The invention discloses a polyimidazolone compound as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a bilateral alkyne ester compound, amidine hydrochloride, a catalyst and a desalting agent in an organic solvent, and carrying out polymerization reaction to obtain the polyimidazolone compound. The polyimidazolone compound with the five-membered ring is selectively generated, and the method has the advantages that monomers are easy to obtain, operation is easy, and by-products are low in toxicity. The polyimidazolone compound prepared by the invention has better machinability and has potential application value in the aspects of metal ion detection and biogenic amine detection.

The invention belongs to the technical field of thickened oil development, and particularly relates to a displacement exploitation method with controllable thickened oil activity. According to the displacement mining method with the controllable heavy oil activity, firstly, fracture development condition analysis is conducted on oil reservoir crude oil reserves, then different slugs are adopted for heavy oil mining according to the fracture development condition, and a water plugging agent, a composite viscosity reducer and a CO2 synergistic huff and puff mode and a CO2 response type alkyl amidine surfactant are adopted in the different slugs; the plugging agent can generate good water channeling plugging, viscosity reduction, gas channeling plugging and other effects, has good oil displacement capacity, can greatly improve the recovery efficiency, and is suitable for heavy oil recovery under harsh conditions.

To provide novel methods for producing fluoro-diiodoalkanes and divinyl perfluoroalkanes, characterized by simplicity, less production equipment limitations, and reduced energy consumption during manufacturing.SOLUTION: The present invention provides a method for producing "R1-CHICH2-Rf-CH2CHI-R1" (fluoro-diiodoalkanes) by reacting a perfluoroalkyl diiodide represented by the general formula (1) I-Rf-I (1) and an unsaturated compound represented by the general formula (2) H2C=CHR1 (2) in the presence of (i) an amine through light irradiation in an organic solvent, or a method for producing "R1CH=CH-Rf-CH=CHR1" (divinyl perfluoroalkane) by reacting the perfluoroalkyl diiodide and the unsaturated compound in the presence of (ii) a cyclic amidine through light irradiation in an organic solvent.SELECTED DRAWING: None

The invention belongs to the technical field of oil exploitation foam plugging agents, and particularly relates to nano-modified CO2 multi-chain alkyl amidine, a CO2 response foam plugging agent, a preparation method and application. The CO2-responsive multi-chain alkyl amidine provided by the invention is obtained by electrostatic adsorption of an active adsorption center (tertiary carbon or tertiary nitrogen) of the multi-chain alkyl amidine and part of negatively charged nano silicon dioxide-calcium carbonate, is sensitive in stimulation response to CO2, has good foaming amount, foam stability and temperature and salt resistance, is environment-friendly and easy to degrade, and has a good application prospect. The foam plugging agent can avoid pollution of an oil layer and plugging of a stratum and can be used for preparing a CO2 response foam plugging agent.

The invention discloses a preparation method of N, N-diethyl alkyl amidine, which comprises the following steps: dissolving N-long-chain alkyl methyl acetimidate and diethylamine in an organic solvent, heating the organic solvent to 20-100 DEG C, reacting at normal pressure for 0.1-100 hours, reducing the pressure of the organic solvent to 0.01-0.08 MPa, reacting at 20-120 DEG C for 0.1-24 hours, and stopping the reaction to obtain the N, N-diethyl alkyl amidine. The N, N-diethyl alkyl amidine is obtained by dissolving the N-long-chain alkyl acetimidic acid methyl ester and the diethylamine in the organic solvent to react, the used raw materials are easy to obtain, the preparation method is simple, the reaction steps are few, operation is easy, toxic and harmful reagents are not needed in the reaction process, environment friendliness is achieved, and the obtained N, N-diethyl alkyl amidine is high in yield, good in purity and suitable for industrial production. The method is suitable for large-scale industrial production, has a wide application prospect, and can be used as a surfactant and a drug synthesis intermediate.

The invention provides a CO2 response type alkyl amidine surfactant with clay stabilization and oil displacement functions and a method for applying the CO2 response type alkyl amidine surfactant to clay stabilization and oil displacement. The surfactant is protonated after contacting with CO2 and is converted into cations from a nonionic form in situ, the generated cations can be efficiently adsorbed on the surface of clay, and the clay is stabilized by inhibiting hydration expansion and changing wettability; the protonated product has excellent foaming performance and emulsifying capacity, so that the protonated product shows good oil washing and oil displacement performance. The surfactant provided by the invention is suitable for low-permeability tight reservoirs of CO2 storage and CO2 oil displacement, and can synchronously solve the two problems of clay expansion damage and improvement of the crude oil recovery rate.

The invention belongs to the field of pesticides, and particularly relates to a phenylamidine compound containing a coumarin structure or a pesticide acceptable salt, a composition and application of the phenylamidine compound, the compound has the structure shown in the formula (I), and all groups in the formula are defined in the specification. According to the compound disclosed by the invention, a substituted coumarin structure is introduced on the basis of an amidine structure, and the compound capable of being used as a bactericide is developed and obtained and has very outstanding biological activity and crop safety.

The application provides a metallocene complex containing amidine group structure. The metallocene catalyst containing amidine group structure provided by the application has double chelated η2-type coordination side arms, can have stronger interaction with the central metal, can reduce the positive electricity of the metal, is more favorable to the stability of the metal center, and improves the temperature resistance of the catalyst. The catalyst can still catalyze ethylene and alpha-olefin copolymerization at 180 DEG C and has higher catalytic activity, alpha-olefin insertion rate and higher molecular weight, is suitable for the needs of large-scale industrial production, and has important industrial application prospect.

This invention discloses a method for synthesizing acetate-promoted amidine cobalt complexes. Specifically, when an N,N'-dialkyl-substituted amidine alkali metal salt reacts with a cobalt precursor, acetate is added as a promoter. The chelating effect of acetate regulates the reaction activity and selectivity, enabling the efficient preparation of amidine cobalt compounds. The reaction yield can reach up to 95%, with a product purity >98%. This invention features readily available raw materials, simple operation, mild reaction conditions, good selectivity for the target product, high synthesis efficiency, and convenient post-processing, making it promising for industrial applications.

A sealing gel with delayed gelation for well cementation, its preparation method, and application are provided. The sealing gel with delayed gelation for well cementation includes 2-3 parts of anionic polyacrylamide, 3-4 parts of cationic acrylamide, 1 part of stabilizer, 1 part of cross-linking agent and 6 parts of distilled water; the stabilizer is obtained by the reaction of citric acid and ethylenediaminetetraacetic acid disodium under the action of initiator, the cross-linking agent is obtained by the reaction of chromium lactate and chromium nicotinate under the action of azo diisobutyl amidine hydrochloride and tetramethylethylenediamine. Based on the purpose of well cementation, the sealing gel has pH sensitivity, which prolongs the gelation time of the gel that is originally rapidly formed at a certain temperature, so that it can be added to the pre-liquid system.

The carbon dioxide responsive liquid crystal film containing amidine compound is formed by a cholesteric liquid crystal polymer capable of reflecting visible light and an amidine compound, and the film is prepared from the amidine compound, cholesteric liquid crystal monomer, crosslinking agent, chiral dopant, photoinitiator and porogen, and the amidine group in the amidine compound reacts with carbon dioxide to increase the hydrophilicity of the polymer network, and when water penetrates into the film, the light reflected by the film is red-shifted and the color is changed accordingly. The carbon dioxide responsive liquid crystal film prepared by the application has stable color change effect, obvious response effect, is easier to distinguish, is still reversible after multiple cycles, and the performance of the film is maintained well after multiple cycles.

Provided is a method for producing a curable composition containing: an organic polymer (A) having a reactive silicon group; an amidine structure-containing compound (b1); a titanium compound or a condensate thereof (b2); and a silane compound (b3) having a hydrolyzable silicon group and an amino group and having a molecular weight of 100-1,500. A catalyst-containing composition (B) obtained by mixing (b1), (b2), and (b3) is prepared, and the organic polymer (A) and the catalyst-containing composition (B) are mixed. The weight ratio (b3) / (b2) is 0.1-2.

The present invention discloses a CO2-responsive adsorbent material, a preparation method thereof, and its application in treating wastewater containing surfactants. The CO2-responsive adsorbent material of the present invention comprises a base sponge and a CO2-responsive polymer. The base sponge is a dopamine-coated sponge grafted with 2-bromoisobutyryl bromide. The CO2-responsive polymer is a homopolymer of any one monomer selected from a primary amine system, an amidine / guanidine system, a tertiary amine system, or a nitrogen-containing azole heterocyclic system, or a copolymer of two or more monomers. When used to treat wastewater containing anionic surfactants, the CO2-responsive adsorbent material of the present invention has a high adsorption capacity, is simple to operate, and is relatively low in cost.

This invention discloses a creatine amidoside hydrolase mutant for creatinine detection, along with methods for selecting, purifying, and detecting the mutant site. The mutant is a single-point mutation of the wild-type full-length amino acid sequence of the creatine amidoside hydrolase protein (Af-CRE) from Alcaligenes faecalis. This invention utilizes machine learning-assisted site-directed mutagenesis to create a creatine amidoside hydrolase mutant with enhanced activity, obtaining a mutant enzyme with improved activity and certain thermostability. Furthermore, it provides methods for purifying and detecting the mutant, overcoming the shortcomings of existing creatine amidoside hydrolases with poor activity that cannot meet the requirements for reagent applications. This lays the foundation for further expanding the industrial applications of creatine amidoside hydrolases.

The invention provides a polyether prepared by polymerizing an alkylene oxide in the presence of a starter, an aluminum compound having at least one hydrocarbyl substituent, and a cyclic amidine. The amount of the phosphorus-nitrogen base present is in a small molar ratio to the amount of the starter. The presence of such a small amount of the cyclic amidine greatly increases the catalytic activity of the system compared to the use of the aluminum compound alone. The product polyether has a small amount of unsaturated polyether impurities and has little or no undesirable high molecular weight fractions. The proportion of primary hydroxyl groups of the propylene oxide polymer is low.

The invention relates to an amidino-containing heterocyclic derivative and application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, pharmaceutically acceptable salt or eutectic of the compound, an intermediate and a preparation method of the compound, and application of the compound in preparation of medicine for treating pain. # imgabs0 #

The objective is to provide a shortened manufacturing method for (alkylsulfonyl)pyridine-N-substituted amidine derivatives or (alkylsulfonyl)pyridine-diazole heterocyclic derivatives that have pest control properties. [Solution] By reacting an (alkylsulfonyl)pyridine-amidine derivative with R6-O-NH2, the corresponding (alkylsulfonyl)pyridine-N-substituted amidine derivative can be directly produced. Furthermore, this manufacturing process provides a shortened manufacturing method for (alkylsulfonyl)pyridine-diazole heterocyclic derivatives.

Compounds useful in inhibiting endo-exonuclease activity and treating cancer have the formula (I):wherein R3 is selected from the group consisting of loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or a halogen; R4 is selected from the group consisting of H, loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or a halogen; and wherein R5 is a loweralkyl; or formula (II):wherein R1 is selected from the group consisting of loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or halogen; R2 is selected from the group consisting of H, loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or halogen; and wherein R5 is a loweralkyl comprising a linear carbon chain of at least two carbons connecting the first “O” to the second “O”.

The present invention relates to methods to use cyclohexan-1,2-dione (CHD) groups to attach labels, linkers, and other molecules to a target compound comprising a CHD-reactive group such as a guanidine, amidine, urea, thiourea and the like. Methods of the invention include milder conditions than those previously known for promoting reaction of CHD with CHD-reactive groups, which makes the methods suitable for use with base-sensitive compounds and complex biomolecules. Methods of the invention are especially useful for attaching linking and labeling groups to a peptide that comprises at least one arginine residue, and can also be used to link such peptides to other target molecules such as nucleic acids. The invention also provides CHD-containing conjugation reagents and compositions comprising CHD-containing intermediates, and precursors useful for making CD-containing compounds that can be used in the methods of the invention.

This invention discloses a method for synthesizing monosubstituted sulfonylamidinium compounds. In an air atmosphere, using commercially available primary sulfonamides and nitriles as substrates, inexpensive trifluoromethanesulfonic anhydride as a catalyst, and trifluorotoluene as a solvent, the product can be efficiently obtained. Compared with existing technologies, this method has the following advantages: inexpensive and readily available reactants; no need for cumbersome synthesis methods; simple reaction system; high atom economy with 100% atom utilization; broad substrate range, compatible with various functional groups; and simple operation.

The present invention discloses a method for synthesizing pyrimidine compounds using a microchannel reaction device, wherein amidine compound I and α,β-unsaturated ketoxime ester compound II are used as reaction raw materials, and a pyrimidine compound shown in formula III is prepared using a microchannel modular reaction device under the action of a catalyst. Compared with the prior art, the present invention uses α,β-unsaturated ketoxime ester compounds and amidine compounds as substrates to prepare new pyrimidine compounds, and the method avoids multi-component reactions and uses cheap metal catalysts to quickly and efficiently synthesize products.

A one-component deacetone type silicone rubber composition comprises a reactive or curable silicone, a deacetone type crosslinker, an organic alkaline catalyst, and a non-amino silane coupling agent, the organic alkaline catalyst comprising alkoxysilane with linear amidine and alkoxysilane with cyclic amidine, the non-amino silane coupling agent comprising silane coupling agent with isocyanurate group and silane coupling agent with imine double bond. The compositions of present invention can be used as sealant which has improved adhesion property, both good oil-resistance property and good chemical medium resistance property. The silicone rubber sealant could be cured at room temperature and has low VOC emission.

The invention discloses a synthesis method of a trifluoromethanesulfonate radical promoted amidino nickel complex. The preparation method comprises the following steps: reacting N, N '-dialkyl substituted amidino alkali metal salt with a nickel precursor, adding trifluoromethanesulfonate as an accelerant, and regulating the reaction rate and selectivity by utilizing the coordination effect of trifluoromethanesulfonate so as to efficiently prepare the amidino nickel complex. In the process, an ether compound is used as a solvent, the reaction is carried out at 0-70 DEG C for 1-48 hours, the reaction yield can reach 90% at most, and the product purity is gt; and 98%. The method has the characteristics of easily available raw materials, simplicity and convenience in operation, mild reaction conditions, good target product selectivity, high synthesis efficiency, convenience in post-treatment and the like, and has industrial application prospects.

The present disclosure provides compositions and methods for sample processing, particularly for oligonucleotide analysis e.g. analysis of formulated nucleic acid drugs. A composition for pretreating at least one target nucleic acid in a biological mixture provided herein includes a chaotropic agent selected from a substituted guanidine, a substituted amidine, a substituted quaternary amine, or a combination thereof, an optional protease, and / or an optional disulfide-reducing agent. Methods of analyzing at least one target nucleic acid in a biological mixture is also provided herein. Furthermore, the present disclosure provides methods for quantifying at least one target cationic lipid interacting with a nucleic acid.

The invention provides an amidine compound containing oxime ether and a preparation method and application thereof.The amidine compound containing oxime ether has the structure shown in the formula I. The amidine compound containing oxime ether has a remarkable effect on prevention and treatment of agricultural and forestry diseases, especially has a good prevention and treatment effect on cucumber powdery mildew and cucumber downy mildew, and is wide in application prospect.

The invention discloses a porphyrinyl hydrogen bond organic framework cascade catalytic material for in-situ encapsulation of biological enzyme and a preparation method thereof. According to the cascade catalytic material, amidine salt, bio-enzyme and porphyrin iron carboxylate are subjected to a one-pot reaction by using a charge-assisted hydrogen bond strategy, so that the porphyrinyl hydrogen bond organic framework (GOx-Fe-HOF) nano catalytic material for in-situ encapsulation of the bio-enzyme is synthesized in a water phase at room temperature, and a Fe-HOF nano enzyme-immobilized GOx enzyme synergistic cascade reactor can be formed; the method is applied to glucose analysis and detection. The cascade catalytic material integrates Fe-HOF room temperature water phase synthesis, biological enzyme in-situ packaging and multi-enzyme cascade analysis, has the advantages of high stability and capability of tolerating harsh environmental conditions, and can be used for preparation of bionic HOF nano functional materials and multi-enzyme cascade reactors and medical and biochemical detection and analysis.

The present inventive concept provides a method for forming a thin film of a perovskite compound, the method comprising: a step for depositing a perovskite compound by reacting at least one compound selected from amine-based compounds and amidine-based compounds, an organometallic compound including a divalent cation, and at least one halogenated hydrogen; and a step for removing impurities present in the perovskite compound.

The application discloses a 4-pentene imino sulfone-based amidine series compound and a preparation method and application thereof. The method uses commercially available imino sulfone and N-allyl alkynyl sulfonamide as reaction substrates, and uses a cheap palladium salt as a catalyst, so that the 4-pentene imino sulfone-based amidine series compound is efficiently synthesized and prepared under a catalytic condition without strict water and oxygen, and at room temperature. The product obtained by the application has novel structure, high production efficiency, wide compatibility of substrate functional groups, conforms to green reaction characteristics, is suitable for large-scale preparation, has excellent industrial application prospect, is an environment-friendly green chemical technology, has wide compatibility of substrate functional groups, conforms to green reaction characteristics, is suitable for large-scale preparation, and is also an environment-friendly green chemical synthesis drug technology.