634 results about "Alkyl substitution" patented technology

The invention relates to the technical field of adsorption materials, and discloses a post-modified imine-COF adsorbent and a preparation method and application thereof, the adsorbent comprises the following structural units: a COF skeleton, which is a two-dimensional or three-dimensional porous skeleton formed by an aromatic aldehyde monomer and an amino monomer through a Schiff base reaction; the imine group is formed in a COF skeleton through a post-modification reaction, and the imine group is-C = NR, r is selected from one or more of a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted cycloalkenyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heterocyclic group and a hydrogen atom. The adsorbent retains excellent structural characteristics of the COF material, realizes high density and uniform distribution of functional groups, and avoids interference of functional monomers on crystal nucleation and growth, so that the adsorption performance of the adsorbent is improved, and the adsorbent can efficiently capture rare earth when being applied to a rare earth-containing solution.

The invention relates to the technical field of chemical synthesis, and discloses a preparation method of anhydrous N, N-dimethyl amino sulfuryl fluoride, which comprises the following steps: (1) introducing sulfuryl fluoride gas into a dimethylamine organic solution to carry out nucleophilic substitution reaction, and then adding triethylamine to obtain a mixed solution containing N, N-dimethyl amino sulfuryl fluoride; and (2) sequentially carrying out normal-pressure rectification and reduced-pressure rectification on the mixed solution containing the N, N-dimethyl amino sulfonyl fluoride to obtain the N, N-dimethyl amino sulfonyl fluoride. According to the method, water is not introduced in the whole process, the risk of water residue is avoided, and the prepared product is high in yield and purity.

The invention discloses a tubular continuous flow preparation process and a tubular continuous flow preparation device for (R)-(+)-2-(4-hydroxyphenoxy) propionic acid. A hydroquinone aqueous solution and a sodium hydroxide solution are respectively preheated and mixed, and then enter a tubular reactor I for reaction to obtain a hydroquinone sodium alkaline solution. And pumping (S)-(-)-2-methyl chloropropionate into a reaction system, respectively preheating the (S)-(-)-2-methyl chloropropionate and the hydroquinone sodium alkaline solution obtained in the previous step, mixing the (S)-(-)-2-methyl chloropropionate and the hydroquinone sodium alkaline solution, carrying out nucleophilic substitution reaction in a tubular reactor II, and carrying out post-treatment on the reaction completion solution to obtain the high-purity (R)-(+)-2-(4-hydroxyphenoxy) propionic acid. According to the method, an optimization method combining a tubular reaction technology and kinetic research is adopted, and MATLAB simulation and experimental verification are combined, so that the reaction yield reaches 95% or above, and the purity reaches 99% or above; the method is high in reaction controllability, fully continuous in reaction process, convenient to operate, low in cost and suitable for industrial production, and the use amount of hydroquinone is greatly reduced.

The invention relates to the technical field of organic dyes, in particular to a novel xanthene dye for blue photoresist color paste and a synthesis method of the novel xanthene dye. The invention relates to a synthesis method of a novel xanthene dye for blue photoresist color paste, which comprises the following steps: 1) taking rigid cyclic amine as a nucleophilic reagent, and carrying out aromatic nucleophilic substitution reaction on a chlorinated xanthene compound to obtain a xanthene intermediate; 2) performing chlorination reaction on the xanthene intermediate by using a chlorination reagent to obtain a chlorinated xanthene intermediate; 3) mixing active amine and the chlorinated xanthene intermediate, and performing substitution reaction under the action of alkali to obtain the novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste has the advantages of being high in solubility, good in thermal stability and high in contrast ratio.

The invention discloses a conjugated polymer photocatalyst, a preparation method thereof and application of the conjugated polymer photocatalyst in photocatalytic synthesis of nitric acid, and belongs to the technical field of polymer materials and photocatalysis. The preparation method of the catalyst mainly comprises the following steps: synthesizing an intermediate 2CzTPN-Br through a nucleophilic substitution reaction, then synthesizing an intermediate TBBA through an esterification reaction, and finally copolymerizing the intermediate 2CzTPN-Br and the intermediate TBBA through a coupling polymerization reaction to obtain the target catalyst. The preparation method disclosed by the invention is controllable in process, and the obtained catalyst does not need to participate in noble metal and has wide light absorption, high specific surface area and excellent carrier separation efficiency; when being applied to photocatalytic synthesis of nitric acid, nitrogen in air can be directly and efficiently converted into nitric acid under the mild conditions of room temperature, air atmosphere and water serving as a solvent, excellent durability is shown, the yield of nitric acid can reach 4466.2 mol g <-1 > cat after 324-hour continuous illumination, and wide application prospects are achieved in the field of green synthesis.

The invention discloses imprinted resin, a preparation method thereof and application of the imprinted resin in platinum recovery. The preparation method of the imprinted resin comprises the following steps: S1, carrying out nucleophilic substitution reaction on chloromethyl polystyrene resin and N-(2-mercaptoethyl) acrylamide in a solvent, and collecting the resin after the reaction is finished; s2, adding a chloroplatinic acid solution into the resin obtained in the step S1, and carrying out a coordination reaction; s3, adding a cross-linking agent and an initiator into the system obtained in the step S2, carrying out polymerization reaction, and collecting resin after the reaction is finished; and S4, adding an eluent into the resin obtained in the step S3, and desorbing chloroplatinic acid radical ions to obtain the imprinted resin. The imprinted resin provided by the invention has high selectivity, high adsorption capacity and good regeneration performance on chloroplatinic acid radical ions, and is suitable for efficient recovery and resource utilization of platinum.

The application provides a preparation method of finerenone and intermediates thereof. The application discloses a preparation method of a finerenone intermediate 5, which comprises the following steps: step 1: in an organic solvent, a resolution reaction is carried out between a finerenone intermediate 2 and D-tartaric acid diphenyl ester to obtain a resolution salt, then an acid-base reaction is carried out between the resolution salt and a base to obtain the finerenone intermediate 3; step 2: in an organic solvent, a nucleophilic substitution reaction is carried out between the finerenone intermediate 3 and triethyl orthoformate in the presence of an acid to obtain a finerenone intermediate 4; step 3: in a solvent, a hydrolysis reaction is carried out between the finerenone intermediate 4 to obtain the finerenone intermediate 5. The preparation method has the advantages of short reaction steps, high total reaction yield, simple and safe operation, simple post-treatment steps, high product purity, low production cost and suitability for industrial production.

A borate compound-containing composition soluble in hydrocarbon solvents. A composition containing base A, or a compound having a total carbon number of not less than 8 and represented by the formula (5):wherein R and R′ are each independently an optionally substituted C1-30 alkyl group, an optionally substituted C3-15 cycloalkyl group, or an optionally substituted C6-14 aryl group; anda borate compound represented by the following formula (1):wherein R1, R2, R3 and R4 are each independently a C6-14 aryl group substituted by one or more fluorine atoms or fluoro C1-4 alkyl groups; and[A-H]+ is a base A-derived cation. A method for producing a polymer, by polymerizing at least one kind of monomer selected from the group consisting of olefins and dienes by using the composition A as a cocatalyst.

The invention relates to the field of polymer functional membrane materials, and particularly provides a composite sulfonated polyarylene ether nitrile sulfone proton exchange membrane and a preparation method thereof. Sulfonated poly (arylene ether nitrile sulfone) is synthesized through nucleophilic substitution reaction, and the sulfonated poly (arylene ether nitrile sulfone) and sulfonated cobalt phthalocyanine are subjected to blending and casting to form a membrane, so that the provided composite sulfonated poly (arylene ether nitrile sulfone) proton exchange resin contains a sulfonic acid structural unit, a sulfone structural unit, a polar cyano group and a phthalocyanine structural unit; the problem that an existing proton exchange membrane is low in sulfonation degree and proton conductivity can be solved, and the proton exchange membrane has the advantages of being high in structural stability, good in mechanical property, excellent in thermal stability and high in safety. The introduction of sulfonated cobalt phthalocyanine can effectively improve the internal structure of the sulfonated polyarylene ether nitrile sulfone proton exchange membrane, promote the conduction rate of water molecules in the membrane, and further improve the proton conductivity of the sulfonated polyarylene ether nitrile sulfone proton exchange membrane. In addition, the manufacturing process is green and simple, the compounding cost is low, and the application prospect is very wide.

The application discloses a preparation method of perfluoroalkyl aryl sulfide, and a structural formula of the perfluoroalkyl aryl sulfide is shown as formula (I); the method comprises the following steps: firstly, obtaining corresponding aryl sulphenyl chloride by chlorination of thiophenol; under the condition that fluoride and crown ether exist, obtaining perfluoro-1,1-dimethylbutyl negative ion by addition of D-2 ‑ And the aryl sulphenyl chloride added is subjected to a nucleophilic substitution reaction to synthesize a product (1,1,1,3,3,4,4,5,5,5-decafluoro-2-trifluoromethylpent-2-yl)(aryl)sulfide. The application adopts a reaction strategy of efficient coupling of thiophenol and perfluoroalkyl, and can be used for preparing various fluorine-containing benzene sulfide compounds.

The invention provides a battery monomer, a power utilization device, a binder and a preparation method of the binder. Each battery monomer comprises a positive pole piece, a negative pole piece and a diaphragm arranged between the positive pole piece and the negative pole piece; the diaphragm comprises a base membrane and a surface coating located on at least one side of the base membrane, the surface coating comprises a binder, and the binder comprises a first polymer; the first polymer comprises a structural unit derived from a first monomer and a structural unit derived from a second monomer, the general formula of the first monomer comprises a structure as shown in a formula I, R1 and R2 independently comprise hydrogen atoms and substituted or unsubstituted alkyl containing 1-3 carbon atoms, substituent groups comprise one or more of carboxyl, amido and hydroxyl, and the structural unit of the first monomer comprises one or more of hydrogen atoms, substituted or unsubstituted alkyl containing 1-3 carbon atoms. The general formula of the second monomer comprises a structure as shown in a formula II, and R3 and R4 respectively and independently comprise a single bond and substituted or unsubstituted alkyl containing 1-10 carbon atoms.

The invention relates to a resin composition, a prepreg, a circuit substrate and a printed circuit board. The resin composition at least comprises: (1) functionalized modified polyphenyl ether resin; (2) hydrocarbon resin, wherein the Vicat softening point of the hydrocarbon resin is 80 DEG C to 240 DEG C; the structural formula of the silicon-nitrogen resin is shown in the formula (1), n is a natural number ranging from 10 to 200, R1, R2, R3, R4 and R5 are independently selected from-H,-OH, amino, C1-C6 alkyl, C1-C6 alkenyl, C6-C12 aryl, C1-C6 alkyl substituted C6-C12 aryl, acrylate or C1-C6 alkyl substituted acrylate, and a molecular chain of the silicon-nitrogen resin at least comprises Si-H groups and Si-vinyl groups. The circuit substrate prepared from the resin composition has high peel strength, high modulus strength, excellent electrical properties and high heat resistance, and has a wide application prospect.

The application discloses a multifunctional biological imbibition agent and a preparation method and application thereof. The preparation method of the multifunctional biological imbibition agent comprises the following steps: (S1), alkylization reaction to obtain alkyl naphthalene; (S2), chloromethylation reaction to obtain halomethyl alkyl naphthalene; (S3), halogen alkyl nucleophilic substitution reaction to obtain hydroxymethyl alkyl naphthalene; and (S4), esterification reaction to obtain the multifunctional biological imbibition agent. The application further discloses application of the multifunctional biological imbibition agent as an imbibition agent in shale oil reservoir oil extraction. The application has the following advantages: (1) the reservoir adsorption amount is small, but the good wetting reversal characteristic is still maintained, and the emulsification is weak; (2) the high-temperature resistance is strong, and the temperature resistance reaches above 200 DEG C; (3) the preparation process is simple, and the yield is high; (4) the dosage is small, the cost is low, and the economic benefit is remarkable.

The invention discloses N-alkylated / sulfonated benzimidazole polyaryletherketone / polyaryletherketone sulfone with controllable grafting density as well as a preparation method and application of the N-alkylated / sulfonated benzimidazole polyaryletherketone / polyaryletherketone sulfone. The preparation method comprises the following steps: firstly, introducing a protecting group on a phenolic hydroxyl group of a bisphenol monomer containing a benzimidazole structure, then carrying out nucleophilic substitution reaction on alkyl halide / alkyl halide sulfonic acid and-NH, and then removing the protecting group to obtain an N-alkylated / sulfonated benzimidazole functionalized bisphenol monomer; copolymerizing the monomer, a bisphenol monomer and a difluoro monomer to obtain a polymer; alkyl or alkyl sulfonic acid is introduced to a benzimidazole ring, so that-NH bonds are passivated, a steric hindrance effect is formed, and gelation of the polymer under a high polymerization degree is avoided; by adjusting the molar ratio of the monomers, the retention stability of the functional groups can be effectively controlled, and compared with the traditional grafting on the polymer, the non-regulation of functionalization and the gelation of the polymer are effectively avoided.

There is provided an on-press development type lithographic printing plate precursor including a support, and an image-recording layer provided on the support, in which the image-recording layer contains (1) or (2).(1) a borate compound represented by Formula (1) and an electron-accepting polymerization initiator(2) a borate compound represented by Formula (1a)in Formula (1) and Formula (1a), R1, R2, R3, and R4 each independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkenyl group, or a substituted or unsubstituted alkynyl group, and R1, R2, R3, and R4 may each independently have a ring structure. Provided that at least one of R1, R2, R3, or R4 is different from the other. M+ represents a cation. Ma+ represents an iodonium cation.

The invention discloses a synthesis method of piperonone, and relates to the technical field of flavors, fragrances and chemical engineering, and the synthesis method comprises the following steps: taking acrylate as a raw material, and carrying out Michael addition reaction with isobutene under the action of Lewis acid to obtain 5-methyl-5-hexenoic acid ethyl ester; the preparation method comprises the following steps: carrying out nucleophilic substitution reaction on ethyl 5-methyl-5-hexenoate and bromoisopropane under the action of a basic catalyst to obtain ethyl 5-methyl-2-isopropyl-5-hexenoate; carrying out self Friedel-Crafts acylation reaction on the 5-methyl-2-isopropyl-5-hexenoic acid ethyl ester under the action of Lewis acid, so as to obtain 5-methyl-2-isopropyl-5-chloro cyclohexanone; and carrying out elimination reaction on the 5-methyl-2-isopropyl-5-chlorocyclohexanone under the action of alkali to obtain the product piperonone. According to the synthetic route, conventional chemical reagents are used as raw materials, reaction conditions are mild, emission of three wastes is reduced to a great extent, and the synthetic route is more environmentally friendly and suitable for continuous industrial production.

The application provides a kind of sodium sulfide nine hydrate and activated olefin / acetylene preparation polyether and its method, belong to sulfur-containing polymer technical field.The structural formula of polyether in the application, R 1 And R 2 Independently be substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;The number of carbon atoms of the alkyl is 1-10, the number of carbon atoms of alkoxy is 1-10, the number of carbon atoms of aryl is 1-30, the number of carbon atoms of heteroaryl is 3-30;Substituted alkyl and substituted alkoxy independently are one or more;N is an integer of 2-4000.The application is used as sulfur source sodium sulfide nine hydrate, under the condition of no metal catalyst, polyether is synthesized by polymerization reaction;Reaction condition is mild, reaction is efficient, economic and environmental protection, meet the current green production concept and can avoid the use of dangerous reagent.

A lens includes an optical polymer represented by:where R1 to R3 are each independently hydrogen, deuterium, halogen, or organic group comprising any one selected from substituted or unsubstituted C1-C60 alkyl group, substituted or unsubstituted C3-C60 cycloalkyl group, substituted or unsubstituted C1-C60 alkoxy group, substituted or unsubstituted C6-C60 aryl group, and substituted or unsubstituted C2-C60 heteroaryl group having at least one hetero atom selected from group consisting of N, O, and S, A1 is a single bond, an oxygen atom, or a sulfur atom, A2 is an oxygen atom or sulfur atom, B1 and B2 are each independently a single bond or an organic group represented by -al-D-al-, and n represents an integer of 5 or more and 500 or less, where al is a C1-C8 alkylene group, and D is —S(═O)2—X—, —X—S(═O)2—, —S(═O)2—X—S(═O)2—, —C(═O)—X—, —X—C(═O)—, —C(═O)—X—C(═O)—, carbonyl, alkenylene, alkynylene, ester, or ether, where X is a C6-C60 arylene group.

The invention discloses a synthesis method of 4-bromo-3-(ethoxymethyl) benzoic acid, which comprises the following steps: (1) activating carboxyl of p-bromobenzoic acid serving as a raw material in the presence of an organic anhydride activator, and then performing chloromethylation reaction with paraformaldehyde in the presence of a chlorine-containing Lewis acid catalyst to obtain 4-bromo-3-(ethoxymethyl) benzoic acid; after the reaction is completed, carrying out post-treatment to obtain an intermediate 4-bromo-3-(chloromethyl) benzoic acid; and (2) carrying out nucleophilic substitution reaction on the intermediate obtained in the step (1) in ethanol under the action of inorganic alkali to prepare the target product 4-bromo-3-(ethoxymethyl) benzoic acid. According to the invention, through one-pot activation and chloromethylation of p-bromobenzoic acid, concise, efficient and highly economical synthesis from cheap raw materials to the sparsentan key intermediate is realized.

This invention belongs to the field of homogeneous catalysis technology, and particularly relates to a method for the hydroformylation of propylene to prepare isobutyraldehyde. The method includes: in the presence of a bidentate P-N ligand and a rhodium metal compound, introducing propylene and syngas to carry out a hydroformylation reaction to prepare isobutyraldehyde. The structural formula of the bidentate P-N ligand is as follows: [Insert structural formula here]. Wherein, R1 is selected from one of C2-C4 alkyl groups, substituted or unsubstituted phenyl groups; R2 is selected from one of hydrogen, C1-C4 alkyl groups, alkoxy groups, substituted or unsubstituted phenyl groups. This method provides a highly active P-N ligand, which, while reducing the amount of rhodium catalyst, maintains high activity and can significantly improve the conversion rate of propylene, as well as the selectivity and yield of isobutyraldehyde.

The application discloses a synthesis method and a reaction system of an aromatic amine compound. The synthesis method of the aromatic amine ionic compound comprises the following steps: in a continuous flow reactor, carrying out a nucleophilic substitution reaction on water, an ionic compound A and a nitrogen source Y to obtain the aromatic amine ionic compound. The preparation method has the characteristics of short reaction time, simple and safe operation and no amplification effect.

A low-temperature dehydrogenation method includes a dehydrogenation reaction of a reactant including a piperidine-based compound substituted with one or more alkyl groups. The dehydrogenation reaction takes place in the presence of a catalyst including an active metal. The active metal includes platinum (Pt), palladium (Pd), or a mixture thereof that is supported on a carrier including a composite metal oxide having alumina (Al2O3) and an additional metal oxide different from alumina, at a low temperature of 150° C. to 250° C., to produce hydrogen.

The invention relates to the technical field of single-molecule devices and sensors, in particular to a graphene single-molecule sensing device based on pillararene as well as a preparation method and application of the graphene single-molecule sensing device. The sensor comprises a pillararene molecule, the functional molecule is covalently connected between a graphene electrode pair through nucleophilic substitution reaction or amide condensation reaction under an alkaline condition, and the stability and the conductive reliability of a molecule-electrode interface are enhanced. According to the present invention, the column aromatic hydrocarbon molecules can selectively perform inclusion on the perfluorocarboxylic acid, and the combination of different types of perfluorocarboxylic acids and the column aromatic hydrocarbon molecules can show the difference characteristic of the conductive state so as to achieve the distinguishing of different perfluorocarboxylic acids, such that the method is hopeful to be used in the detection of perfluorocarboxylic acid. Meanwhile, perfluorocarboxylic acid can be effectively desorbed through methanol treatment, and an I-V signal is recovered to an initial state, so that the device has reusability. The preparation method provided by the invention is stable in process, high in repeatability and beneficial to large-scale production.

This invention relates to low-odor extreme pressure agents, gear oil additive compositions, gear oil compositions, and methods for their preparation. The extreme pressure agents comprise components having the structure shown in Formula I, where n is a positive integer from 1 to 5; R1 and R2 may be the same or different; R1 and R2 are independently selected from C... 1～12 Alkyl, substituted or unsubstituted C 3～10 cycloalkyl, substituted or unsubstituted C 6～14 aryl or the structure shown in Formula II; in Formula II, R3 is selected from C 1‑4 Alkylene; the substituted C 3～10 Substituents of cycloalkyl groups, substituted C 6～14 The substituents of the aryl group are each independently selected from hydrogen, halogen, and C. 1～5 One or more alkyl groups. The extreme pressure agent and gear oil additive composition of the present invention has a low odor, mainly solving the problem of unbearable odor caused by the addition of sulfurized isobutylene in existing products.

This application discloses a purino[1,2-a]carbazolin derivative, its preparation method, and its application. Specifically, it discloses a compound having the structure shown in Formula I, or its stereoisomers, solvates, metabolites, pharmaceutically acceptable salts, cocrystals, or prodrugs: ; wherein R1 and R2 are each independently selected from hydrogen, hydroxyl, carboxyl, substituted or unsubstituted C1-C6 alkyl, -CONH-R3, and -COO-R4; wherein R3 is a substituted or unsubstituted C1-C5 alkyl, and the substituent can be any of cyano, halogen, alkylC1-C5 alkoxy, C1-C5 alkylsulfonyl, di(C1-C5 alkyl)amino, nitrogen-containing heterocyclic, aryl, and C1-C5 heteroaryl; R4 is selected from any of substituted or unsubstituted aryl C1-C5 alkyl and nitrogen-containing saturated heterocyclic C1-C5 alkyl. This compound can be used as a TDP1 inhibitor for antitumor therapy.

This invention relates to the field of chemical hydrogen storage, and discloses a carbon-based catalyst, its preparation method and application, and a method for the dehydrogenation of methylcyclohexane. The catalyst comprises nitrogen (N), carbon (C), hydrogen (H), and platinum nanoparticles; the catalyst has the following properties: "Pt x C y N z H a The schematic chemical composition of the catalyst is shown in the figure, where z:a = 1.5~5; z:x = 5~50; z:y < 0.016; in the catalyst, nitrogen atoms are covalently bonded to at least two carbon atoms; nitrogen atoms are covalently bonded to hydrogen atoms; the carbon tetrachloride adsorption value (CTC) of the catalyst is ≥80%; in the XRD spectrum of the catalyst, the A of the Pt(111), (200), (220), (222) crystal plane diffraction peaks of the platinum nanoparticles is ≥85%, and A = (Pt(111) peak area) / (peak area of ​​Pt(111) + peak area of ​​Pt(200) + peak area of ​​Pt(220) + peak area of ​​Pt(222))) × 100%. This catalyst has good catalytic activity and low hydrogenolysis activity, making it particularly suitable for dehydrogenation reactions, such as the dehydrogenation reaction of alkyl-substituted cycloalkanes. It can effectively control the hydrogenolysis reaction during the dehydrogenation process and reduce the generation of by-products. It is especially suitable for the application of methylcyclohexane dehydrogenation reaction. After the dehydrogenation reaction, the conversion rate of methylcyclohexane is high, and the methane content in the product is <0.3wt%.

The invention provides an indole compound and a solar cell. The indole compound has a structural formula as shown in a formula (I). At least one of R1-R7 has a structure as shown in a formula (Hy1): L1 is any one of substituted or unsubstituted C6-C30 arylene, substituted or unsubstituted C3-C30 heteroarylene, substituted or unsubstituted C1-C30 alkylene, substituted or unsubstituted C1-C30 alkyleneoxy and substituted or unsubstituted C1-C30 alkylenesulfenyl, and R8 is any one of a phosphate group, a carboxylic acid group and a sulfonic acid group; when R1-R7 do not represent the structure represented by formula (Hy1), R1-R7 represent the structure represented by formula (Hy1); a substituted or unsubstituted C1-C30 alkyl group, a substituted or unsubstituted C1-C30 alkoxy group, a substituted or unsubstituted C1-C30 alkylthio group, a substituted or unsubstituted C6-C30 aryl group, a substituted or unsubstituted C6-C30 arylamino group, a substituted or unsubstituted C3-C30 heteroaryl group, a substituted or unsubstituted C3-C30 heteroarylamino group, a substituted or unsubstituted C3-, each independently selected from hydrogen, halogen, nitro, hydroxyl, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C1-C30 alkoxy group, substituted or unsubstituted C1-C30 alkylthio group, substituted or unsubstituted C6-C30 aryl group, substituted or unsubstituted C3-C30 heteroarylamino group, substituted or unsubstituted C3- and C12 cycloalkyl is selected from any one of C12 cycloalkyl.

The invention belongs to the technical field of organic compounds, and particularly discloses an indolinone compound and a synthesis method thereof. The molecular structural formula of the indolinone compound is shown as a formula (A), and the synthesis method of the indolinone compound comprises the following steps: S1, carrying out an amide condensation reaction on a compound shown as a formula (1) to generate a compound shown as a formula (2); s2, performing aminolysis reaction on the compound as shown in the formula (2) to generate a hydrazide compound as shown in a formula (3); s3, carrying out nucleophilic substitution reaction on the compound as shown in the formula (4) to generate a compound as shown in a formula (5); and S4, carrying out condensation reaction on the compound as shown in the formula (3) and a compound as shown in a formula (5) to generate the indolinone compound as shown in a formula (A). The indolinone compound provided by the invention is novel in structure, mild and simple in synthesis method and high in yield, and the indolinone compound is also found to be effective in antibiosis.

This invention discloses a method for synthesizing acetate-promoted amidine cobalt complexes. Specifically, when an N,N'-dialkyl-substituted amidine alkali metal salt reacts with a cobalt precursor, acetate is added as a promoter. The chelating effect of acetate regulates the reaction activity and selectivity, enabling the efficient preparation of amidine cobalt compounds. The reaction yield can reach up to 95%, with a product purity >98%. This invention features readily available raw materials, simple operation, mild reaction conditions, good selectivity for the target product, high synthesis efficiency, and convenient post-processing, making it promising for industrial applications.

The invention relates to the technical field of organic chemistry, in particular to a method for synthesizing a benzothiophene coupling product through a non-metal-participated anchoring-migration strategy. The method comprises the following steps: taking a benzothiophene compound or a benzothiophene sulfoxide compound as a reaction substrate, mixing the reaction substrate with an aryl nucleophilic reagent in the presence of an anhydride activator and a solvent, and carrying out nucleophilic substitution reaction to obtain benzothiophene sulfonium salt; the preparation method comprises the following steps: mixing benzothiophene sulfonium salt with an organic solvent, and carrying out metal-catalysis-free intramolecular migration reaction to form a carbon-carbon bond at the C2 site of benzothiophene, thereby obtaining the benzothiophene coupling product. The preparation conditions are mild, the operation is simple and convenient, a traditional oxidation addition-reduction elimination process is replaced by an anchoring-migration strategy, protection of a noble metal catalyst, a complex ligand, strong base or inert gas is not needed, and the problems of high cost, metal residues, harsh reaction conditions and limited substrate applicability in the prior art are fundamentally solved.