579 results about "Decarboxylation" patented technology

Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.

The invention relates to a decarboxylation coupling method catalyzed by N-heterocyclic carbene. Small organic molecule N-heterocyclic carbene is used as an organic catalyst, manganese is used as a reducing agent, aromatic acid or derivatives thereof and an electrophilic reagent are subjected to cross coupling, and multi-structure ketone is prepared. Small organic molecule N-heterocyclic carbene is used as an organic catalyst, manganese is combined as a reducing agent, cross coupling of aromatic acid or derivatives thereof and some cheap and easily available electrophilic reagents can be promoted, ketones with various structures can be provided at high yield, and the method is especially suitable for preparation of high-steric-hindrance ketone compounds and has wide application prospects. The method has the advantages of high yield, convenience in separation, high efficiency, mildness, low-cost economy and high industrial application value, and the requirement on transition metal catalysis can be reduced.

The invention relates to the technical field of microorganisms, and particularly discloses a recombinant microorganism and application thereof in fermentation production of decarboxylated carnosine. Compared with an original strain, the recombinant microorganism disclosed by the invention has the advantages that the expression of the mdtK gene is enhanced; the starting strain is escherichia coli capable of producing decarboxylated carnosine. When the recombinant microorganism is used for fermentation production, the yield of the decarboxylated carnosine can be increased, L-histidine, histamine or beta-alanine and other precursors do not need to be added in the production process, and an effective novel method is provided for industrial production of the decarboxylated carnosine.

The invention discloses a synthesis method of 2-bromomethyl-5-trifluoromethyl furan, which comprises the following steps: S1, carrying out reaction on acetoacetate and halogenated trifluoroacetone under the action of an alkaline substance and a catalyst to generate a 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product; s2, carrying out a cyclization reaction on the 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product, so as to obtain a 2-methyl-5-(trifluoromethyl) furan-3-formate crude product, and carrying out a cyclization reaction on the 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product to obtain a 2-methyl-5-(trifluoromethyl) furan-3-formate crude product; s3, adding an alkaline substance into the crude product, carrying out hydrolysis, and adding acid to adjust the pH value after the hydrolysis is completed, so as to obtain 2-methyl-5-(trifluoromethyl) furan-3-formic acid; s4, the 2-methyl-5-(trifluoromethyl) furan-3-formic acid is subjected to a heating decarboxylation reaction, and 2-methyl-5-(trifluoromethyl) furan is obtained; and S5, carrying out a bromination reaction on the 2-methyl-5-(trifluoromethyl) furan and a bromination reagent to obtain a final product 2-bromomethyl-5-(trifluoromethyl) furan. The raw materials used in the synthesis method are easy to obtain, use of control chemicals is not involved, and industrialization is easy to achieve.

The present invention relates to the fields of medicine and cosmetology, and discloses a cell active peptide composition that promotes the regeneration of multi-type collagen structural proteins, its preparation method, and its application in medicine and cosmetology. The composition uses raw materials such as tripeptide-10 citrulline, hexapeptide-9, hydrolyzed sodium hyaluronate, γ-aminobutyric acid, decarboxylated carnosine hydrochloride, acetyl tetrapeptide-3, acetyl tetrapeptide-11, palmitoyl dipeptide-7, and palmitoyl pentapeptide-4. The composition can promote the coordinated expression of skin type I, type III, type IV, type VII, type XVII collagen, fibronectin, elastin, and glycosaminoglycans; prevent collagen cross-linking, maintain triple helix structure, and inhibit collagen degradation. Applied to dermatology and cosmetology, it can accelerate the regeneration of structural proteins such as skin collagen, repair skin damage, reduce wrinkles such as crow's feet, tear groove lines, nasolabial folds, and under-eye lines, solve the skin aging problem caused by the loss of structural proteins such as collagen, and improve skin elasticity and firmness.

The invention discloses a preparation method of modified carboxymethyl cellulose lithium for a lithium ion battery, and belongs to the technical field of chemical modification of natural polymer materials, decarboxylation and acidification are performed simultaneously, hydrolysis and lithiation are performed simultaneously, and preparation and purification are simple; a branched structure is grafted on lithium carboxymethyl cellulose, additional carboxyl and hydroxyl are introduced after grafting and hydrolysis, the lithium content of the obtained modified lithium carboxymethyl cellulose is higher than that of common lithium carboxymethyl cellulose, and the grafted branched polymer contains a multi-hydrogen-bond structure, so that the adhesive property is enhanced.

The invention relates to the field of medicine synthesis and preparation, in particular to a synthesis method of toxyanib phosphate. The use amount of acetic acid is greatly reduced in the preparation process, so that excessive acid does not need to be neutralized in the post-treatment process, and a large amount of wastewater is not generated; in addition, the use amount of sodium nitrite is reduced, and the environment and health are facilitated; the enamine reduction reaction does not use acetic acid as a solvent and a hydrogenation reaction catalyzed by heavy metal palladium, so that the safety of the reaction is improved, and the purity of the product is also improved; a decarboxylation reaction and a Vilsmeier-Haack reaction are carried out by a one-pot method, so that the reaction steps are reduced, and the product purity is improved; when aldol reaction is carried out in side chain splicing, side reaction and generation of isomer impurities are reduced. The method is short in route, mild in reaction condition, low in equipment requirement and convenient to operate, industrial production is easy to achieve, and a complex purification method is not needed.

The invention belongs to the field of organic synthetic chemistry, and relates to a preparation method of melatonin and meerythrine indole derivatives and compounds. Specifically, the indole derivative is efficiently synthesized by taking arylamine and carboxylic acid as raw materials through a one-pot two-step reaction in the presence of catalysis of ferric chloride hexahydrate (FeCl3. 6H2O), a ligand, a diazotization reagent, an additive and a solvent under the conditions of visible light irradiation, inert atmosphere and room temperature. According to the method, visible light induced iron-based LMCT catalysis and iron lewis acid catalysis functions are integrated, and efficient integration of diazotization, decarboxylation, free radical coupling and cyclization reaction is achieved. The method has the advantages that raw materials are cheap and easy to obtain, reaction conditions are mild, substrate applicability is wide, functional group compatibility is good, operation is easy, convenient and safe, and environment friendliness is achieved, gram-level scale preparation can be achieved, and a green and efficient synthesis path is provided for indole compounds with biological activity such as melatonin and meerythrine.

The invention discloses application of laccase as a catalyst in catalytic synthesis of allantoin. According to the invention, laccase from thermophilus is used as an enzyme catalyst, uric acid is oxidized, hydrolyzed and decarboxylated to synthesize allantoin, and efficient biosynthesis of allantoin is realized under mild conditions; wherein the amino acid sequence of the laccase derived from the thermophilic fungi is as shown in SEQ ID NO. 1. The invention provides an efficient, environment-friendly and low-cost biosynthesis approach for biosynthesis of allantoin, and has industrial application prospects in biosynthesis of allantoin.

The invention relates to a method for producing a release agent (2), wherein the method comprises at least the following steps: a) providing a reactive mixture comprising a carboxylic acid-containing monomer component, which comprises, preferably and / or consists of, itaconic acid and / or itaconic acid derivatives; b) polymerizing the reactive mixture to form a polymer solution, wherein the polymer solution comprises a polymer which is at least partially dissolved in a solvent and which has the carboxylic acid-containing monomer component, c) obtaining a release agent (2) comprising the polymer solution, wherein from the release agent, preferably the polymer of the release agent, CO 2 is releasable; as well as a release agent (2) and a use of the release agent (2).

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a control method for a process impurity 2-ethyl valeric acid (EP-B) in preparation of valproic acid or sodium valproate by a diethyl malonate method. According to the method disclosed by the invention, the content of 2-ethyl-2-propylmalonic acid process impurities in dipropylmalonic acid is controlled, so that the content of 2-ethylvaleric acid (EP-B) which is a process impurity in valproic acid or sodium valproate is accurately controlled; adding a polar solvent into the dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying to obtain a high-purity dipropylmalonic acid refined product; high-purity valproic acid (RRT is equal to 1.00) is prepared through decarboxylation of the dipropyl malonic acid fine product, and the purity is 99.779%; 0.020% of 2-ethyl valeric acid (RRT is equal to 0.90); and valeric acid (RRT = 0.77), 0.039%. The valproic acid product quality meets the requirements of European Pharmacopoeia. According to the method, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a diethyl malonate method are solved.

The invention discloses a hybrid central metabolic network chassis cell with both carbon atom economy and energy generation pathway as well as a construction method and application of the hybrid central metabolic network chassis cell, and belongs to the technical field of genetic engineering and microorganisms. The Escherichia coli central metabolic network is reconstructed, so that the Escherichia coli central metabolic network has a carbon sequestration module and an energy generation module at the same time. The carbon sequestration module continues to fix CO2 while avoiding CO2 release caused by pyruvic acid decarboxylation, the highest carbon yield can reach 133%, the carbon yield exceeds that of an NOG pathway reported only from the perspective of no CO2 release, and the carbon yield is two times that of a natural glycolysis pathway. And the direct product of the constructed mixed type central metabolic network is acetyl coenzyme A, and the acetyl coenzyme A contains an energy generation module, so that the chassis cell provided by the invention can meet the synthesis requirements of acetyl coenzyme A derivatives with high or low required reducing power, and has universality.

The invention relates to the technical field of pesticides, and discloses a fluopyram compound and a preparation method thereof. The preparation method of the fluopyram compound comprises the following steps: 1) in the presence of a first organic solvent and first alkali, carrying out nucleophilic substitution reaction on a compound with a structure as shown in a formula (1) and a compound with a structure as shown in a formula (2); 2) carrying out a decarboxylation reaction on the nucleophilic substitution reaction product obtained in the step 1) in the presence of a first solvent and a first acid; 3) in the presence of a second solvent and a second acid, the decarboxylation reaction product obtained in the step 2) is subjected to a decyanation reaction to obtain the fluopyram compound, in the formula (1), X represents halogen, and R1 represents-COOC1-6 alkyl; in formula (2), R2 represents an alkyl group having 1-6 carbon atoms. According to the preparation method of the fluopyram compound, the yield is higher, and the operation is more convenient. # imgabs 0 # formula (1) # imgabs 1 # formula (2).

The invention belongs to the field of chemical synthesis, and particularly relates to a synthetic method of cyclobutyl-containing methyl propionate and propylene glycol derivatives. Specifically, dimethyl methylmalonate represented by a formula A and a quaternary tension ring substrate represented by a formula B are taken as basic raw materials, under the action of a catalyst, a quaternary ring-containing methyl propionate represented by a formula C is prepared through a nucleophilic addition reaction, and further a propylene glycol derivative represented by a formula D or a formula E: # imgabs0 # is prepared through a decarboxylation reaction or a reduction reaction.

A method for providing a cargo to a C-terminal end of a peptide comprises a first stage and a second stage, wherein the first stage comprises reacting the C-terminal end of the peptide with a first reactant in the presence of a first catalyst and first radiation to provide a first intermediate, wherein the first catalyst is configured to decarboxylate the C-terminal end of the peptide in the presence of the first radiation; and wherein the second stage comprises exposing the first intermediate to a second reactant.

Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase. In some specific embodiments, the method relates to the decarboxylation of a cannabinoid performed in a short-path distillation apparatus or a thin-film distillation apparatus.

The invention relates to a method for preparing high-molecular-weight polyethylene furandicarboxylate by a one-step method, and belongs to the technical field of bio-based polyester materials. The method comprises the following steps: weighing raw materials including 2, 5-furandicarboxylic acid, ethylene glycol, an end group regulator, a protective agent, a decarboxylation inhibitor and a catalyst, mixing and adding into a reaction container, introducing nitrogen, maintaining the pressure of the nitrogen in the reaction container to be 50-150 kPa, carrying out esterification reaction, heating and vacuumizing until the pressure is less than or equal to 50 Pa after the esterification reaction is completed, and carrying out polycondensation reaction to obtain the 2, 5-furandicarboxylic acid. And carrying out extrusion and drying so as to obtain the high-molecular-weight polyethylene furandicarboxylate, wherein the high-molecular-weight polyethylene furandicarboxylate is obtained. According to the method, the FDCA conversion rate is larger than or equal to 98%, the number-average molecular weight of the obtained product is larger than or equal to 32 kg / mol, no heavy metal residues exist, and the method is suitable for large-scale production of high-end bio-based packaging materials.

The invention discloses a method for synthesizing thioamide through photocatalysis. According to the method, sulfur powder, ketonic acid and amine are taken as starting raw materials, and the thioamide compound is synthesized in a green and efficient manner through dehydration condensation, photooxidation reduction decarboxylation and coupling sulfur insertion at room temperature under blue light irradiation. The method designed by the invention is novel and efficient, the raw materials are green and odorless, the synthesis method is simple, the conditions are mild, the yield is higher, the substrate application range is wide, and the method has very strong popularization potential.

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a method for preparing a high-purity dipropylmalonic acid refined product by adding a polar solvent into a dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying. Decarboxylating the refined dipropylmalonic acid product to obtain high-purity valproic acid; distilling the filtrate to recover the polar solvent to obtain 2-methyl-2-propylmalonic acid, and carrying out decarboxylation on the 2-methyl-2-propylmalonic acid to obtain 2-methylpentanoic acid; 2-methylvaleric acid is used as a perfume additive. According to the method disclosed by the invention, the process impurity 2-methyl-2-propylmalonic acid in dipropylmalonic acid is separated, and the process impurity 2-methylvaleric acid (EP-L) in valproic acid or sodium valproate is precisely separated; the quality of the valproic acid product prepared by the method disclosed by the invention meets the requirements of European Pharmacopoeia EP-11 (2023). According to the invention, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a dimethyl malonate method are solved.

The invention relates to a decarboxylated carnosine derivative as well as a preparation method and application thereof. The structural formula of the decarboxylated carnosine derivative is shown as a formula (I), wherein R is selected from C5-C21 alkyl and C5-C21 unsaturated chain alkyl. Compared with decarboxylated carnosine, the decarboxylated carnosine derivative disclosed by the invention has a more excellent anti-saccharification effect; meanwhile, a relatively good anti-oxidation effect is achieved; moreover, the decarboxylated carnosine derivative disclosed by the invention has certain lipophilicity, is relatively easy to penetrate through a skin cuticle, is good in skin permeability and relatively good in stability, can be used for preparing cosmetics for resisting saccharification, resisting oxidation, resisting skin aging and the like, and has an important market value. # imgabs0 #

The invention belongs to the field of cosmetics, and particularly discloses an ormosia henryi bark extract-containing composition capable of nourishing, repairing and brightening skin as well as a preparation method and application of the composition. The composition comprises an active component, a solubilizer, polyol, phospholipid and water, wherein the active ingredients comprise an ormosia henryi bark extract, acetylchitosamine, decarboxylated carnosine or salt thereof and a coast pine bark extract. Active ingredients in the composition are good in solubility in the composition, the composition is good in stability, good in skin permeability and good in AGEs inhibition effect, the four active ingredients including the ormosia henryi bark extract, the acetylchitosamine, the decarboxylated carnosine and the coast pine bark extract are in mutual synergistic interaction, and an excellent unexpected technical effect is achieved.

The invention discloses a mercury-resistant and mercury-removal Leclercia adcarboxsaca and an application thereof. The strain number of the Leclercia adecarboxyla disclosed by the invention is W13, and the preservation number of the Leclercia adecarboxyla is CGMCC (China General Microbiological Culture Collection Center) NO.34142. The strain disclosed by the invention is an efficient growth-promoting bacterial strain capable of resisting mercury, removing mercury and promoting growth, and particularly has a very strong effect on removing mercury by promoting mercury volatilization; in addition, the strain can be colonized in miscanthus sinensis, promote growth of miscanthus sinensis in a mercury-polluted environment, promote absorption of miscanthus sinensis to mercury in soil and promote volatilization of mercury in soil, so that the combination of Leclercia adcarboxamide and miscanthus sinensis can effectively repair mercury-polluted soil, and has a wide application prospect in treatment of mercury-polluted soil.

The invention discloses a method for improving soluble expression of non-ribosome peptide synthetase in escherichia coli. According to the method, a polyion oligopeptide label is connected to the N end or the C end of the non-ribosome peptide synthetase; the method comprises the following steps: adding a polyion oligopeptide tag (D) 5 at the N / C end of ebony in a fusion protein SGE formed by non-ribosomal peptide synthetase ebony for producing decarboxylated carnosine and phosphokinase Sfp through a connecting peptide GSG, or replacing a GSG sequence in an original SGE sequence with the polyion oligopeptide tag (D) 5 to construct new plasmids, and transforming the obtained three new plasmids in recombinant escherichia coli to obtain the decarboxylated carnosine-producing non-ribosomal peptide synthetase ebony-phosphokinase Sfp. The solubility of the non-ribosome peptide synthetase in escherichia coli is greatly improved, and the addition of the polyion oligopeptide tag (D) 5 at the N end is more beneficial to reducing the formation of inclusion bodies and improving the yield of decarboxylated carnosine.

The invention provides a preparation method of an omariglitazone intermediate, which comprises the following steps: by taking p-halogenated benzaldehyde as a raw material, carrying out aldol condensation reaction, hydrolysis, decarboxylation, reduction, ring closing and the like to obtain an intermediate as shown in a formula 9, carrying out catalytic reaction, reduction reaction, ring closing and the like to obtain an intermediate as shown in a formula 13, and finally hydrolyzing to obtain a target product omariglitazone intermediate A. According to the invention, links of precious metal use and chiral resolution (key steps influencing cost and yield) in the prior art are avoided, and a method for synthesizing a single configuration through a chemical method is adopted, so that the yield is greatly improved, and the production cost is greatly reduced; meanwhile, a synthesis route is broken through, a target product is synthesized through cheap initial materials, and post-treatment is simpler and more controllable.

The present invention relates to a process for preparing aniline or an aniline conversion product, comprising the steps of (A) providing aminobenzoic acid; (B) decarboxylating the aminobenzoic acid in a reactor at a reaction temperature in the range from 170° C. to 350° C. to give aniline and carbon dioxide, wherein the decarboxylation is conducted at a reaction pressure at which the boiling point of aniline is reached or—preferably—exceeded, such that a first, liquid, phase possibly containing solid particles and a second, gaseous, phase form in the reactor, with a gaseous stream containing aniline and carbon dioxide being discharged from the reactor; and (C) condensing and optionally purifying the aniline present in the gaseous stream; and (D) optionally, converting the aniline obtained in (C) to an aniline conversion product.

The invention discloses a method for preparing a biological hydrocarbon compound by organic photocatalysis higher fatty acid decarboxylation, which comprises the following steps: adding higher fatty acid, a hydrogen atom transfer catalyst and an acridine photocatalyst / solid-phase acridine photocatalyst into a reaction solvent, stirring and reacting for 12-24 hours under the conditions of blue light irradiation and room temperature to obtain a reaction solution, filtering, washing and drying to obtain the biological hydrocarbon compound. And removing the reaction solvent of the obtained reaction solution under reduced pressure, and purifying by thin layer chromatography / column chromatography to obtain the long-chain alkane compound after decarboxylation of the higher fatty acid. The method is simple in step, mild in reaction condition and high in product yield, does not use any metal compound, and has the characteristics of high atom economy and environmental protection. And for unsaturated carboxylic acid, olefin configuration before and after decarboxylation is not influenced. When solid-phase acridine is used as a photocatalyst for reaction, the catalyst can be recycled through simple washing, filtering and recycling, excellent catalytic activity can still be kept after the catalyst is recycled for more than 10 times, and the reaction cost is further reduced.

The invention relates to a synthesis method of milobalin or acid salt thereof, and belongs to the technical field of medicine synthesis. In order to solve the problem that chiral resolution needs to be adopted in the prior art, the invention provides a synthesis method of miloabalin or an acid salt thereof, which comprises the following steps: under the action of an organic strong base, carrying out Michael addition reaction on a compound shown as a formula III and acetonitrile in a non-polar organic solvent at a low temperature of-50 DEG C or below to obtain an intermediate product; under the alkaline condition, the intermediate product is subjected to an oxidation reaction and a hydrolysis reaction under the action of an oxidizing agent, after the reaction is finished, an intermediate product is obtained through acidification, and the intermediate product is subjected to a high-temperature decarboxylation reaction in an aprotic solvent to obtain a compound of a formula VI; and carrying out Hofmann degradation reaction on the compound of formula VI to obtain the compound of formula I miloabalin or miloabalin acid salt. The method has the advantages of high stereoselectivity, no need of chiral resolution operation, avoidance of the problem of large material loss caused by resolution, high chiral purity and high yield.

The present invention relates to a decarboxylated carnosine derivative, a preparation method thereof and an application. The structural formula of the decarboxylated carnosine derivative of the present invention is shown in formula (I), wherein R is selected from: C5-C 21 alkyl group, C5-C 21 unsaturated hydrocarbon group. The decarboxylated carnosine derivative of the present invention has a more excellent anti-glycation effect compared with decarboxylated carnosine; meanwhile, it has good antioxidant effect; and, the decarboxylated carnosine derivative of the present invention has certain lipophilicity, is relatively easy to penetrate through the skin cutin layer, has good skin penetration performance, and has good stability at the same time. It can be used for preparing cosmetics with anti-glycation, antioxidant, anti-skin aging and other functions, and has important market value#imgabs0#(I).

The invention discloses a salicylic acid decarboxylase mutant and application of the salicylic acid decarboxylase mutant in degradation of salicylic acid. The mutant is obtained by carrying out site-specific modification on salicylic acid decarboxylase NahG, and specifically, valine at the 46th site, tyrosine at the 380th site and leucine at the 382nd site of an amino acid sequence shown in SEQ ID NO.2 are mutated into cysteine, phenylalanine and phenylalanine at the same time. The mutant shows remarkably improved catalytic efficiency, and salicylic acid can be efficiently and thoroughly decarboxylated and converted into catechol under mild conditions. The invention also provides a coding gene, a recombinant vector and an engineering bacterium of the mutant. The mutant not only can be used for efficient bioremediation of salicylic acid pollution, but also can effectively break through and accelerate a naphthalene catabolism pathway due to the characteristic of directionally generating catechol, and has important application value in the fields of environmental pollution abatement and biological catalysis.

The present invention relates to a technical field of photocatalytically increasing carbon chain length, and in particular to a method for photocatalytically increasing carbon chain length by decarboxylation coupling of coconut oil fatty acids to produce aviation fuel and co-produce hydrogen. Coconut oil fatty acids and Pt@C3N4 catalysts are added to a photocatalytic reactor, and the atmosphere in the reactor is replaced with an inert gas and then sealed, stirred and mixed, and a decarboxylation coupling reaction occurs under the irradiation of an external light source to produce aviation fuel and co-produce hydrogen. Compared with the existing process, it has the advantages of low catalyst cost, low energy consumption, and no consumption of hydrogen, and the reaction can generate an equivalent amount of hydrogen. The present invention provides a new technical approach for converting low-quality oils and fats to prepare bio-aviation fuel.