54 results about "Decarboxylation" patented technology

A method to produce a mixture comprising poacic acid (X) and poacidiene (Y) and the resulting product-by-process. The method includes the steps of subjecting a solution of ferulic acid to a free-radical coupling reaction to yield an intermediate mixture comprising ferulic acid dehydrodimers and decarboxylating the intermediate mixture to yield a product mixture containing poacic acid (X) and poacidiene (Y).

The present application relates to a kind of preparation methods and systems of electronic grade dimethyl carbonate prepared from dimethyl oxalate, the method comprises the following steps: dimethyl oxalate is preheated and sent into decarboxylation reactor to carry out decarboxylation reaction, carbon monoxide, dimethyl carbonate and other light components are extracted from the top of decarboxylation reactor, and heavy components are extracted from the bottom of decarboxylation reactor;Carbon monoxide, dimethyl carbonate and other light components extracted are separated after gas-liquid, and liquid phase dimethyl carbonate is sent into rectifying column to carry out rectification purification;Electronic grade dimethyl carbonate product is obtained by crystallization purification in refrigeration crystallization device after rectification, and crystallization mother liquor returns rectifying column;Decarboxylation reactor is three-stage reaction tower, and rectifying section, reaction section, stripping section are sequentially from top to bottom.The present application is completely reacted by the design of three-stage decarboxylation reactor;Heavy components generated are extracted in real time, and catalyst stability is high;Electronic grade DMC is prepared by using rectifying column coupled with crystallization tower, and the yield of DMC is significantly improved.

The present invention provides a novel room-temperature extraction system and method for cannabis and hemp, utilizing custom membrane filtration to efficiently isolate cannabinoids, terpenes, and other bioactive compounds while reducing energy consumption. This multi-stage system begins with a custom milling machine that preprocesses biomass by separating non-target components, such as cellulose-rich stalks, to improve extraction efficiency. The core extraction process employs a series of custom membranes designed to selectively filter cannabinoids and terpenes, minimizing impurities without the need for traditional sub-zero cooling. Each membrane stage incorporates solvent recovery to recycle ethanol, reducing waste and operational costs. In the final stage, a custom concentrator removes residual ethanol, decarboxylates THCa to THC, and crystallizes sugars to prevent downstream clogging. This room-temperature extraction system significantly enhances yield, purity, and sustainability, making it a scalable and cost-effective solution for cannabis and hemp processing industries, as well as applicable for pharmaceutical and nutraceutical uses.

This invention discloses a method for preparing a key intermediate of iodopyridine, using dimethyl malonate as a raw material, and sequentially undergoing dihydroxylation S1 → acetalization S2 → hydrolysis and acidification S3 → decarboxylation S4 to obtain iodopyridine. The raw materials of this invention are inexpensive and readily available in the market, and the reaction efficiency is high, improving the purity and yield of the product. Intermediates 1 and 2 obtained from the process do not require separation and purification operations and can be directly used in the next step of the reaction. The purification effect is significant, yielding intermediate products with a purity ≥99%, and the total yield of the five steps is as high as 65-70%, which is beneficial for large-scale production.

This application relates to a method for producing cadaverine dicarboxylate (cadaverine verphosphate or cadaverine azelaate), comprising a first step of culturing L-lysine-producing microorganisms in a medium supplemented with dicarboxylic acid in the form of diammonium dicarboxylate to obtain lysine dicarboxylate, and a second step of converting lysine dicarboxylate to cadaverine dicarboxylate. According to this application, by carrying out the process according to the above procedure, high-purity cadaverine dicarboxylate (cadaverine verphosphate or cadaverine azelaate) can be obtained without ion resin exchange, decarboxylation, and distillation steps.

This invention discloses a UV-photolysis product based on citrus fruits and its application in cosmetics. Citrus fruits are rich in citric acid, which, as a β-hydroxy polyacid, readily undergoes decarboxylation free radical reactions to generate smaller molecular weight organic acids such as glycolic acid. Furthermore, polysaccharides and monosaccharides in citrus fruits can also be degraded into small molecule organic acids such as citric acid and glycolic acid under the action of free radicals. Therefore, this invention adds hydrogen peroxide as a free radical source, generating hydroxyl free radicals upon UV irradiation. By adjusting the free radical concentration, the bidirectional growth of citric acid and glycolic acid is achieved, resulting in new therapeutic effects. This invention achieves full utilization of citrus fruit juice and pomace, reducing waste generation. Simultaneously, the raw materials obtained from UV-photolysis of citrus fruits possess excellent soothing, oil-controlling, and exfoliating effects.

This application relates to a method for producing cadaverine dicarboxylate (cadaverine sebacate, cadaverine undecane diate, or cadaverine dodecane diate), comprising a first step of culturing L-lysine-producing microorganisms in a medium supplemented with dicarboxylic acid in the form of diammonium dicarboxylate to obtain lysine dicarboxylate, and a second step of converting the lysine dicarboxylate to cadaverine dicarboxylate. According to this application, by carrying out the process according to the above procedure, a high-purity cadaverine dicarboxylate (cadaverine sebacate, cadaverine undecane diate, or cadaverine dodecane diate) can be obtained without ion resin exchange, decarboxylation, or distillation steps.

This invention relates to an industrial preparation method for 2-methylphenylacetic acid, comprising the following steps: under an inert solvent, 2-methylhalobenzene and malonate diester undergo a coupling reaction in the presence of a catalyst and base A to obtain compound one; compound one is hydrolyzed and decarboxylated under the presence of base B to prepare 2-methylphenylacetic acid; the chemical structural formula of compound one is: [formula missing], where R is a C1-C8 alkyl group. Compared with existing technologies, this invention uses inexpensive raw materials, is simple to operate, can react under normal pressure, has relatively mild conditions, is safe and environmentally friendly, and is easy to industrialize.

This invention discloses an apparatus and method for synthesizing ethylene carbonate (EC) from CO2 and propionic acid (a bio-waste), belonging to the fields of electrochemical synthesis and CO2 resource utilization. The invention designs a bipolar ethylene-producing unit electrolytic cell and an air-flotation cyclic electrolytic unit electrolytic cell. This invention achieves the coupling of anode propionic acid (a waste acid from biorefining) decarboxylation and cathode CO2 reduction, simultaneously converting the two wastes into C2H4 at ambient temperature and pressure. Furthermore, using C2H4 and CO2 as raw materials, high-efficiency synthesis of ethylene carbonate (EC) can be achieved in a membrane-free electrolytic cell. This invention relies on renewable electrical energy, uses green raw materials, and enables the resource utilization of biomass waste propionic acid and CO2. Combined with the carbon-neutral potential of the cascade route, it provides a feasible solution for the industrial-scale green production of EC.

The present application relates to the technical field of organic synthesis, and particularly relates to an asymmetric preparation method of nicotine and derivatives thereof.The method of the present application takes nicotinic acid ester or substituted nicotinic acid ester and N-methyl pyrrolidone as raw materials, obtains a hydrochloride intermediate through condensation and ring-opening decarboxylation, then obtains chiral amino alcohol through asymmetric reduction, and finally obtains nicotine and analogs thereof through intramolecular ring-closing reaction.The preparation method disclosed by the present application has the advantages that raw materials are easy to obtain, operation is convenient, the process is short, the obtained product nicotine and derivatives thereof are easy to purify, and the optical purity is high.

Provided is a production method for chlorotrifluoroethylene and trifluoroethylene, which does not use freon and uses inexpensive raw materials that are by-products of Ishikawa reagent, and which can easily produce the chlorotrifluoroethylene and trifluoroethylene. Provided is a production method for chlorotrifluoroethylene, which includes: (A3) a process A3 of decarboxylating 2,3,3,3-tetrafluoro-2-chloropropionic acid in an anhydrous state in the presence of a base to obtain the above-described chlorotrifluoroethylene; or (B3) a process B3 of chlorinating trifluoroethylene to obtain the above-described chlorotrifluoroethylene.

The present application belongs to the field of biological catalysis and green chemistry, and particularly relates to a method for producing main components of sustainable aviation fuel by using photoenzyme decarboxylation reaction, comprising the following steps: S1, constructing a fatty acid photo-decarboxylase mutant; screening optimal chlorella; S2, extracting chlorella fatty acid photo-decarboxylase gene from the screened optimal chlorella; S3, constructing an engineering bacterium; S4, extracting active fatty acid photo-decarboxylase from the engineering bacterium; S5, immobilizing the active fatty acid photo-decarboxylase to obtain immobilized fatty acid photo-decarboxylase; S6, converting long-chain fatty acids into mixed products containing hydrocarbons by using the immobilized fatty acid photo-decarboxylase; and S7, separating and purifying the mixed products containing hydrocarbons to generate alkane products as aviation fuel mixed components. The present application has the advantages of mild process, high carbon conversion rate and low production cost, and the produced alkane products have high purity, meeting the quality requirements of sustainable aviation fuel components in industrial applications.

Provided is a method for preparing 8-aminooctanoic acid. Starting from diethyl 2-(6-halohexyl)malonate (III), a crude product of 8-aminooctanoic acid is obtained by a condensation reaction with phthalimide, hydrolysis with dilute sulfuric acid, decarboxylation, and deprotection. High-purity 8-aminooctanoic acid is then obtained by recrystallization in a solvent. The method has the advantages of simplified process, easy availability of raw materials, high yield, ease of separation and purification, less waste, cost-efficiency, ease of industrialization, and the like.

This utility model relates to the field of monoketal preparation technology, specifically a decarboxylation reactor for monoketal production, comprising a reactor body, a stirring device, and a drive device for driving the stirring device to rotate. The reactor body is provided with a feed valve at the top and a discharge pipe at the bottom, forming a cylindrical reaction chamber inside. The stirring device includes a vertically arranged hollow stirring shaft, which is rotatably connected to the center position of the top of the reactor body through a bearing assembly. This utility model achieves dynamic coupling of axial circulation, radial shearing, and particle dispersion of materials through the synergistic action of the three-section stirring shaft's helical propeller, cylindrical first stirring blade, and serrated dispersing blade, significantly improving mixing efficiency and shortening reaction time. The wall scraping mechanism drives the elastic scraper to rotate in the opposite direction through a magnetic commutator, adaptively conforming to the reactor wall to remove scale. Combined with the staggered shearing action of the second stirring blade and the main stirring blade on the scraper, a multi-directional turbulent flow is formed to enhance the mixing effect.

The application discloses a kind of continuous flow photocatalytic decarboxylation preparation biological hydrocarbon method, belong to the technical field of biofuel preparation.The method includes the following steps: high fatty acid compound, hydrogen atom transfer catalyst and acridine photocatalyst are dissolved in organic solvent, and mixed solution is obtained;The mixed solution is passed into circulating continuous flow light reactor, and photocatalytic decarboxylation reaction is carried out at room temperature for 12-24 hours, and reaction liquid is obtained;Reaction liquid is separated by reduced pressure distillation, and the biological hydrocarbon compound after decarboxylation is obtained.The application uses continuous flow light reactor to strengthen mass transfer and heat transfer efficiency, solves the problem that light penetration depth is limited in traditional batch photoreactor, and reaction is not uniform;Metal-free catalytic system is used, and the use of noble metal and potential residual risk is avoided.The method has mild reaction condition, higher product yield, good atom economy, and for unsaturated high fatty acid, olefin configuration can be maintained before and after decarboxylation, and has good industrial application prospect.

This invention discloses a mutant of sulfoalanine decarboxylase with enhanced enzyme activity and its application in taurine production, belonging to the fields of enzyme engineering and biocatalysis. Using sulfoalanine decarboxylase from *Tribolium castaneum* as the original enzyme, this invention constructed a mutant library using random mutagenesis technology and combined it with high-throughput screening methods to obtain a mutant with significantly enhanced catalytic performance. Enzymatic characterization results showed that, compared with the original enzyme, the enzyme activity of this mutant in catalyzing the decarboxylation of sulfoalanine to taurine was increased by 3.25 times. This mutant can effectively promote the biosynthesis of taurine and has good application prospects in related biomanufacturing processes.

This application relates to the fields of genetic engineering and enzyme engineering, specifically to an ornithine decarboxylase mutant, gene, recombinant plasmid, recombinant strain, and its applications. The ornithine decarboxylase mutant is obtained by mutating the wild-type ornithine decarboxylase with the amino acid sequence shown in SEQ ID NO.1, and the mutation sites of the ornithine decarboxylase mutant include any one or more of Y104F, A264V, Q263E, R157K, S325C, and V265A. By performing single-point or multi-site combination mutations on the wild-type ornithine decarboxylase, a high-activity ornithine decarboxylase mutant is obtained, thereby significantly improving the substrate conversion rate of the ornithine decarboxylation reaction and the synthesis efficiency of butanediamine. This successfully overcomes the rate-limiting bottleneck of the ornithine decarboxylation reaction in the synthetic pathway from glucose to ornithine and then to butanediamine, significantly optimizing the overall efficiency of this metabolic pathway.

The application belongs to the technical field of medical organic synthesis, and particularly relates to a preparation method of an oxazole ester compound. The oxazole ester compound is prepared by using N-ethoxyoxalyl-alpha-alanine ethyl ester (oxalate) as a starting material, adding a catalytic amount of rare earth cerium trichloride as a catalyst under the action of triphenylphosphine dichloride and an organic base, and promoting a chloro-cycloaddition reaction by using a rare earth coordination effect. The obtained oxazole ester can be further subjected to saponification and decarboxylation to obtain a vitamin B6 intermediate 4-methyl-5-ethyloxazole. The reaction rate is significantly accelerated and the reaction yield is improved by using the coordination effect of the rare earth cerium trichloride, the amount of the cerium trichloride is as low as 0.003%, and the cerium trichloride is easy to recover. The process does not need to use imidazole compounds as a catalyst, and the problem of difficult recovery of imidazole is avoided. The process is green, environmentally friendly, safe, simple and convenient to operate, the yield and purity of the target product are high, and the process is suitable for industrial production.

This invention relates to an aryl benzocyclooctadiyne compound, its preparation method, and its application, belonging to the field of organic synthesis technology. In the preparation method of this invention, o-aryl diacetonitrile compound A and o-aryl dicarboxaldehyde compound B are used as starting materials, and the corresponding aryl benzocyclooctadiyne compounds are synthesized through sequential cyclization coupling, hydrolysis, decarboxylation, bromination, and elimination bromination reactions.

This invention relates to the field of pharmaceutical intermediate synthesis, specifically to a method for synthesizing 3,4-difluoro-2-methoxyphenylacetic acid. The method includes the following steps: Compound III reacts with diethyl malonate in the presence of a copper catalyst, a nitrogen-containing ligand, and base I; then, an inorganic strong base II is directly added for hydrolysis, followed by acidification to obtain compound IV; compound IV undergoes decarboxylation in an acidic solution to yield 3,4-difluoro-2-methoxyphenylacetic acid (compound I) with a purity of up to 99.3% and an overall yield of up to 74.04%. This invention features a simple route, mild reaction conditions, low cost, environmental friendliness, stable yields at each step, and simple post-processing, making it suitable for industrial production.

The present disclosure relates generally to processes for handling renewable hydrocarbon feeds and conventional hydrocarbon feeds. One aspect of the disclosure provides a process for co-processing a renewable feed and a petroleum feed, the process comprising: hydrotreating the petroleum feed in a first reaction one, wherein the hydrotreating of the petroleum feed comprises one or more of hydrodesulfurization, hydrodenitrogenation, hydrodemetallization, isomerization, hydrogenation of olefins, and hydrocracking, to form a first reaction zone effluent; conducting the first reaction zone effluent to a second reaction zone; and in the second reaction zone hydrotreating a combination of the first reaction zone effluent and the renewable feed, wherein the hydrotreating of the combination comprises one or more of hydrodeoxygenation, decarboxylation, decarbonylation, isomerization and hydrogenation of olefins of the renewable feed, to form a second reaction zone effluent.

This invention provides a method for preparing (E)-octyl-4-en-1,8-diic acid, comprising the steps of reacting diethyl malonate and allyl chloride as raw materials first in the presence of an organic base, then in the presence of a catalyst, and finally obtaining (E)-octyl-4-en-1,8-diic acid through hydrolysis and decarboxylation. The starting materials of this invention are inexpensive and readily available, the reaction operation is simple, the conditions are mild, the safety is good, and the product yield and purity are high, making it of great value for widespread application.

The present invention provides a process for the production of THC comprising contacting a first non-halogenated non-polar solvent with a non-decarboxylated plant material; separating a first mixture comprising the non-halogenated non-polar solvent and THCA from the non-decarboxylated plant material; separating the first non-halogenated nonpolar solvent from the first mixture to yield an extract comprising THC and a first non-halogenated non-polar solvent content equal to or less than 5% w / w, as determined by GC-MS; mixing the THCA extract with a second non-halogenated non-polar solvent to yield a second mixture having a weight / volume ratio of THCA extract to the second non- halogenated non-polar solvent ranging from 1:0.15 to 1:0.5; maintaining the second mixture at an appropriate temperature and time to obtain THCA crystals; separating the THCA crystals from the second mixture; and decarboxylating the THCA crystals at a temperature ranging from 120°C to 160°C, during a time ranging from 30 to 110 minutes. The invention also relates to a THC having a purity of at least 95% w / w, containing 0.10% w / w CBC or less.

This invention discloses a method for preparing 3-chloro-1H-pyrazole-5-amine. The target product is prepared via a three-step reaction involving cyclization, chlorination, and decarboxylation, starting with ethyl ethoxymethylene cyanoacetate. Hydrazine hydrate is used for cyclization, dichlorohydantoin for chlorination, and dilute sulfuric acid for decarboxylation. This process is mild, simple to operate, highly safe, and requires minimal equipment, making it suitable for large-scale production. The yield of compound III is up to 61.6%, compound IV to 44.2%, and compound I to 64%. The purity of all products, as determined by HPLC, reaches 99%, effectively improving production efficiency.

This invention discloses a method for synthesizing an intermediate of ennadustat, belonging to the pharmaceutical field. The method uses ethyl cyanoacetate and benzaldehyde as starting materials, undergoing a Knevengel condensation reaction, followed by reduction to obtain compound 4. Compound 4 undergoes nucleophilic substitution with compound 5 to obtain compound 6. Compound 6 is then hydrolyzed and decarboxylated to obtain the key intermediate compound 7. This invention uses inexpensive and readily available ethyl cyanoacetate and benzaldehyde as starting materials, and successfully constructs the key intermediate of ennadustat through a tandem process of Knevengel condensation, Hans ester reduction, nucleophilic substitution, and hydrolysis decarboxylation. The entire process avoids the use of expensive palladium catalysts, fundamentally solving the problem of heavy metal residues. Furthermore, the reaction conditions are mild, the operation is simple, the yield is greatly improved, the product purity is high, and the reduced cost makes it more suitable for industrial production.

This application relates to a method for producing cadaverine dicarboxylate (cadaverine succinate or cadaverine gluthrate), comprising a first step of culturing L-lysine-producing microorganisms in a medium supplemented with dicarboxylic acid in the form of diammonium dicarboxylate to obtain lysine dicarboxylate, and a second step of converting lysine dicarboxylate to cadaverine dicarboxylate. According to this application, by carrying out the process according to the above procedure, high-purity cadaverine dicarboxylate (cadaverine succinate or cadaverine gluthrate) can be obtained without ion resin exchange, decarboxylation, and distillation steps.

The application discloses a synthesis method of alpha-substituted arylacetamide compounds. The method is based on a light-driven iron-catalyzed decarboxylative arylalkylation reaction system of ligand-metal charge transfer (LMCT) mechanism, can efficiently couple readily available N-arylacrylamide with commercial and various carboxylic acids, and can prepare a series of alpha-substituted arylacetamide compounds containing acyclic quaternary carbon stereogenic centers with high chemical selectivity. The system is suitable for various carboxylic acid substrates, including primary, secondary and tertiary alkyl carboxylic acids and complex biological active carboxylic acid molecules.