130 results about "Medium chain fatty acid" patented technology

The invention discloses a trifarotene external preparation and a preparation method thereof, and relates to the technical field of preparation of trifarotene preparations. The trifarotene external preparation is prepared from the following raw materials in percentage by mass: 1.0 to 5.0 percent of trifarotene, 6 to 12 percent of gel base material, 10 to 15 percent of polylactic acid, 5 to 7.5 percent of cellulose, 1 to 2.5 percent of penetration enhancer, 8 to 14 percent of water-retaining agent, 5 to 9 percent of surfactant and the balance of water, the gel base material comprises medium-chain fatty glyceride and polycarbophil, and the mass ratio of the medium-chain fatty glyceride to the polycarbophil is (2.5-4): 1. According to the novel trifarotene external preparation provided by the invention, the raw material formula is coordinated and matched, so that the hardening and setting time of the medicine is reasonably matched with the slow release time of trifarotene capable of ensuring the effective concentration. After the medicament layer is completely hardened, the drug release of the trifarotene is basically completed. The raw materials used by the medicament are mild, the medicament layer is soft and moderate, the skin covering area is small, and the discomfort basically does not exist.

The invention discloses a method and a system for producing high-purity medium-chain fatty acid (MCFA) based on waste molasses two-stage regulation fermentation. Comprising the following steps: (1) diluting waste molasses, then adding a compound enzyme agent of pectinase, beta-glucanase and cellulase, and coupling microwave to assist treatment; (2) inoculating the pretreated waste molasses with a composite flora containing a clostridium kluyveri mutant strain and a Megasphaera elsdeni engineering bacterium, and carrying out a fermentation treatment on the waste molasses, wherein the composite flora contains the clostridium kluyveri mutant strain and the Megasphaera elsdeni engineering bacterium; (3) sequentially performing two-stage dynamic regulation and control fermentation on the waste molasses inoculated with the composite flora through a pH-stat control strategy to realize efficient conversion from butyric acid to hexanoic acid / octanoic acid; and (4) a hydrophobic hollow fiber membrane module is adopted to realize on-line removal of the product, and the inhibition effect of the product is relieved. According to the technology, the yield of the MCFA produced from the waste molasses reaches 0.45 g / g COD, the cost is reduced by 68% compared with that of a traditional substrate, and a new way is provided for recycling of sugar manufacturing waste.

The present invention relates to a pharmaceutical composition for oral administration comprising a GLP receptor agonist or a pharmaceutically acceptable salt or derivative thereof, one or more penetration enhancers, one or more mucous membrane adhesives, and one or more basifying agents. More preferably, the penetration enhancer is a penetration enhancer based on medium chain fatty acids.

The invention belongs to the technical field of anaerobic fermentation of organic wastes, and discloses a method for producing medium-chain fatty acid by promoting anaerobic fermentation of excess sludge by using blue iron ore, which comprises the following steps: inoculating anaerobic sludge by using excess activated sludge from a municipal sewage treatment plant as a fermentation substrate, adding the blue iron ore and a methanogenesis inhibitor, adjusting the pH value, and fermenting to obtain the medium-chain fatty acid. Carrying out anaerobic fermentation in the presence of an electron donor to produce medium-chain fatty acid; due to the addition of the blue iron ore, the electron transfer capability of microorganisms in a carbon chain extension process can be enhanced, so that the yield of medium-chain fatty acid in a fermentation product is increased; the addition amount of the blue iron ore in the system is 2-20g / L. According to the method, the blue iron ore is introduced into a system for producing the medium-chain fatty acid from the sludge, the addition amount of the blue iron ore in the system is strictly controlled, the blue iron ore is used as an electron mediator, and the electron transfer efficiency of microbial fermentation in the process of producing the medium-chain fatty acid from the sludge is enhanced, so that the yield of the medium-chain fatty acid is increased; further, efficient utilization of sludge resources is realized.

The invention provides a compound feed for promoting beef cattle growth and improving meat quality and a production method thereof, and belongs to the technical field of feed preparation. The compound feed comprises the following components in parts by weight: 100 parts of basal feed, 7-10 parts of a functional additive and 0.3-0.5 part of disodium inosinate, and the functional additive comprises a postbiotic compound, a fatty acid regulating agent, a bacterium enzyme synergist and trace elements, wherein the metagen complex comprises a lactobacillus plantarum metagen extract and a bacillus coagulans metagen extract, the fatty acid regulating agent comprises conjugated linoleic acid glyceride and medium-chain fatty acid, and the bacterial enzyme synergist comprises beta-mannase and bacillus subtilis. According to the compound feed, the growth performance and the meat quality can be synchronously improved, and a reliable processing technical guarantee is provided for improving the growth performance and the meat quality of beef cattle.

The application belongs to the technical field of functional food, and particularly discloses a meal replacement powder for weight loss of obese patients and a preparation method thereof. The meal replacement powder comprises whey protein powder, composite dietary fiber (containing at least two kinds of konjac powder and the like), functional carbohydrate, functional fat (containing medium-chain fatty acid and the like), and composite vitamins, minerals, functional additives (L-carnitine and the like), and stability additives. The preparation comprises raw material pretreatment, small material premixing, large material mixing, microencapsulation of fat-soluble components, total mixing, sterilization and packaging, and the key lies in that the fat-soluble components are wrapped by wall materials and spray dried into microcapsules. The meal replacement powder can balance nutrition, strengthen satiety, promote fat metabolism, avoid muscle loss and electrolyte imbalance, has a shelf life of 12 months at room temperature, has good palatability, has good weight loss effect (average weight loss of 5.8 kg in 2 months), has no adverse reactions, and is suitable for long-term weight loss diet management of obese patients.

The invention belongs to the technical field of sewage treatment, and discloses a method for strengthening anaerobic fermentation of sludge and synchronously producing medium-chain fatty acid and hydrogen. The method comprises the following steps: settling and concentrating sludge, mixing the sludge with alkaline biochar, adding potassium ferrate for reaction to obtain pretreated sludge, adjusting the pH value, mixing the pretreated sludge with an electron donor and inoculated sludge, and carrying out anaerobic fermentation to obtain fermentation liquor rich in medium-chain fatty acid and hydrogen. An alkaline biochar-potassium ferrate coupling system is utilized to crack extracellular polymeric substances and cell walls of the sludge, so that particle organic matters are driven to be dissolved, and the activity of methane bacteria is inhibited; fe2O3 derived from potassium ferrate and biochar form an iron-carbon complex in situ, and a composite technology with triple functions of pretreatment, electronic regulation and methane inhibition is formed by strengthening electron transfer efficiency and enzyme activity and promoting an organic matter acidification process and a carbon chain extension reaction, so that synchronous recovery of medium-chain fatty acid and hydrogen is realized; the sludge treatment efficiency is improved.

The invention discloses an asymmetric gemini-like surfactant constructed based on non-covalent bonds as well as a preparation method and application of the asymmetric gemini-like surfactant, and belongs to the technical field of fire-fighting foam extinguishing agents. The preparation method comprises the following steps: mixing medium-chain fatty acid and polyether amine D230 according to a certain molar ratio in a nitrogen atmosphere, heating in a water bath to a reaction temperature, fully stirring for 15 minutes, and constructing through a non-covalent bond to obtain an intermediate; and adding long-chain fatty acid into the intermediate according to a certain molar ratio, keeping the reaction temperature, continuously stirring for 15 minutes, obtaining a product through non-covalent bond construction, and carrying out vacuum drying for more than 12 hours to obtain the asymmetric gemini-like surfactant. The prepared asymmetric gemini-like surfactant has the advantages of being high in foaming capacity, long in half-life period and low in surface tension, and is suitable for replacing a fluorocarbon surfactant to be used as a foaming agent in an environment-friendly foam extinguishing agent.

The invention discloses a complete feed suitable for sows in a perinatal period and a preparation method of the complete feed in the technical field of animal nutrition and feed science, and relates to a beta-glucan sulfated-chitosan conjugate and a nano-embedded quercetin-medium-chain fatty glyceride compound, and application of the beta-glucan sulfated-chitosan conjugate and the nano-embedded quercetin-medium-chain fatty glyceride compound in the complete feed. Wherein the beta-glucan sulfated-chitosan conjugate is formed by carrying out sulfated modification on beta-glucan through chlorosulfonic acid and then carrying out covalent coupling on the modified beta-glucan and chitosan under the conditions of a specific condensing agent and pH (Potential of Hydrogen). The complete feed contains the energy raw material, the protein raw material, the functional additive and the two modified compounds, and is prepared through the processes of step-by-step crushing, mixing and granulation, the complete cycle regulation of relieving constipation, promoting ingestion, reducing oxidative damage and improving lactation performance is finally achieved, and the breeding efficiency of sows and the health level of piglets are remarkably improved.

Plants producing seeds and seeds comprising increased medium chain fatty acid content are provided. Oil compositions that are produced from the seeds are also provided. Additionally, methods for generating and using plants, seeds, and oil compositions having increased medium chain fatty acid content are disclosed.

The invention relates to the technical field of food processing, and particularly discloses a preparation method of medium-chain fatty acid oil powder capable of promoting weight loss, which comprises the following steps: S1, preparing a nano-emulsion: mixing medium-chain triglyceride (MCT) oil, sodium caseinate and citrus pectin with esterification degree of 20-35% according to a mass ratio of (6-8): (1.2-1.8): (0.6-0.8), adjusting the solid content to 25 + / -3% (w / w), and uniformly stirring to obtain the nano-emulsion; shearing and emulsifying for 8 minutes at a high speed of 12000 rpm at 55 + / -2 DEG C to obtain a crude emulsion; s2, high-pressure homogenization: homogenizing the crude emulsion in the step S1 under the pressure of 80MPa for three times for circulation to obtain a nano-emulsion with the particle size of 150 + / -30nm; s3, preparing a flavor masking system: mixing beta-cyclodextrin and menthol according to a mass ratio of 12: 1, and stirring at 45 DEG C for 2.5 h to enable the entrapment rate of menthol to be greater than or equal to 93% so as to obtain an entrapment product; by adopting a preparation method combining a nano emulsion technology and freeze drying, the particle size of the medium-chain fatty acid oil powder is remarkably reduced, so that the dispersity and the dissolution rate of the medium-chain fatty acid oil powder in water are greatly improved.

The invention provides an agricultural waste hydrolytic acidification method and a method for synthesizing medium-chain fatty acid, and belongs to the technical field of agricultural waste resource utilization. The invention provides an agricultural waste hydrolytic acidification method which comprises the following steps: after adjusting the solid content of agricultural waste, mixing the agricultural waste with short-chain AHLs and DPD-loaded chitosan microspheres to obtain a hydrolytic acidification system; and carrying out anaerobic fermentation on the hydrolytic acidification system to obtain a hydrolytic acidification product. According to the method, short-chain AHLs are added in the hydrolytic acidification process of the agricultural wastes to activate related genes of hydrolytic acidification bacteria, so that biofilm formation and extracellular enzyme secretion are promoted, the hydrolytic acidification efficiency of a substrate is improved, and substrate decomposition and short-chain fatty acid accumulation are promoted; dPD is released in a delayed manner in the metabolic peak period of acid-producing bacteria, the metabolic division of hydrolytic bacteria and acid-producing bacteria is coordinated, the activity of methanogens is inhibited, substrate competition is reduced, the degradation rate of agricultural waste cellulose is increased, and the yield of medium-chain fatty acid precursor substances such as acetic acid in fermentation substrates is increased.

The present application relates to the organic wastewater and greenhouse gas carbon dioxide resource utilization, biological energy and biological electrochemical engineering cross technical field, disclose a kind of system and method for preparing middle chain fatty acid and sustainable aviation fuel in cooperation, system with organic wastewater as carbon source and electron donor, short-chain organic acid is converted into middle chain fatty acid by anaerobic microorganism carbon chain extension reaction, and is separated in situ by liquid membrane extraction and enriched;Enriched product is introduced into microbial electrosynthesis reactor, and further carbon chain extension is carried out by anode Kolbe electrolysis catalysis, and C10-C14 sustainable aviation fuel is prepared;Carbon dioxide is used as carbon source in cathode, and is converted into acetic acid by microbial catalysis, and carbon chain extension is carried out again by co-fermentation with organic wastewater.The present application realizes the synergic integration of organic wastewater treatment, carbon dioxide resource utilization and high value-added fuel preparation, and has high resource utilization degree, high carbon utilization efficiency and significant environmental benefits.

The application discloses a preparation method of medium and long chain fatty acid triglyceride, and belongs to the technical field of oil deep processing. Firstly, plant oil and medium chain fatty acid triglyceride are used as substrates, a low eutectic solvent is used as a reaction medium, and an ester exchange reaction is carried out under the catalysis of immobilized lipase; after the reaction is completed, centrifugal treatment is carried out, and the low eutectic solvent, the immobilized lipase and the reaction product are recovered respectively; the recovered low eutectic solvent and the immobilized lipase are used for the next batch of reaction, and the recovered upper oil phase is the reaction product. The application uses immobilized lipase to catalyze ester exchange to prepare medium and long chain fatty acid triglyceride in a low eutectic system, the substrate conversion rate and the product generation amount are high, the product separation is easy, further separation and purification are not needed, the low eutectic solvent is green, environment-friendly and reusable, and the method has good ecological, economic benefits and industrialization application prospects.

The invention belongs to the technical field of treatment and recycling of breeding tailings, and particularly relates to a bacterial strain for producing medium-chain fatty acid and a device and a method for preparing the medium-chain fatty acid. The bacterial strain for producing the medium-chain fatty acid is enterobacter YTLJ-N-S18; the enterobacter YTLJ-N-S18 is preserved in Guangdong Microbial Culture Collection Center on July 5, 2021, the preservation number is GDMCC No: 61773, the enterobacter is classified and named as Enterobacter sp., and the preservation address is Guangzhou in China. According to the method, the medium-chain fatty acid-producing efficient bacteria are utilized, the original fermentation process of solid wastes such as tailings of a breeding system is changed, and a new breeding solid waste treatment mode is finally realized.

To provide a food product with reduced adhesion, an oil composition for manufacturing the food product, a method for manufacturing the food product, and a method for reducing the adhesion of a food product.SOLUTION: A food product comprising an oil composition containing an emulsifier with an HLB of 3-8 at 0.05-15 mass% and edible oil at 80-99.95 mass% is provided. The edible oil contains an oil composition comprising medium-chain fatty acid triglycerides with 6-12 carbon atoms as constituent fatty acids at 50-100 mass%. The food product has a hardness of 200-20,000 N / m2 and an adhesion of 1,500 J / m3 or less. Further, a method for manufacturing a food product having a hardness of 200-20,000 N / m2 and an adhesion of 1,500 J / m3 or less, comprising the step of mixing the oil composition is provided. Furthermore, a method for reducing the adhesion of a food product by mixing the oil composition, and the oil composition for manufacturing the food product are provided.SELECTED DRAWING: None

The invention discloses a method for producing medium-chain fatty acid through a core-shell structure magnetic polymer material reinforced biological carbon chain lengthening reaction, which comprises the following steps: by taking a perishable organic solid waste as a raw material, adding core-shell structure magnetic polypyrrole, adding a culture medium solution containing a substrate, adding a domesticated inoculum, and carrying out a reaction for 2-3 hours; a fermentation system for producing hexanoic acid through biological carbon chain lengthening is constructed for reaction, the reaction temperature is 30-40 DEG C, and the pH value is weak acidity; according to the magnetic polypyrrole with the core-shell structure, ferroferric oxide is used as a core, and polypyrrole is used as a shell; the problems that single magnetic particles are agglomerated, magnetic components are prone to loss, and traditional materials are difficult to recycle and large in adding amount are solved, and the performance stability and the reaction promoting capacity are enhanced by means of the structural advantages of the materials. Meanwhile, the efficiency of the carbon chain lengthening reaction and the yield of medium-chain fatty acid are remarkably improved, and high-valued conversion of the perishable organic solid waste is achieved.

The present invention relates to a composition for preventing and treating viral infection of the family of African swine fever viruses, in particular, a composition for treating, inhibiting and / or preventing viral infection of the family of African swine fever viruses (Asfaraviridae), preferably African swine fever virus, characterized in that the composition comprises one or more medium-chain fatty acids (MCFAs) and / or derivatives thereof.

This invention relates to ketogenic nutritional powder containing medium- and long-chain fatty acid triglycerides, its preparation method, and its application. It belongs to the field of food science and engineering technology. It uses enzymatically synthesized medium- and long-chain fatty acid triglyceride structured lipids as the sole fat source, which is different from the traditional physical mixture of long-chain triglycerides and medium- and long-chain oils. Medium-chain fatty acids and long-chain fatty acids are simultaneously bound to the same glycerol molecule. Fatty acid digestion and absorption are synchronized and metabolized, which can give full play to the synergistic nutritional advantages. It retains the characteristics of medium-chain fatty acids that provide rapid energy and are not easy to accumulate in body fat, while also supplementing essential fatty acids such as linoleic acid and α-linolenic acid. At the same time, it overcomes the disadvantages of pure medium-chain fatty acid oils that cause great gastrointestinal irritation and have a low smoke point.

The invention belongs to the technical field of food processing, and relates to a preparation method and application of astaxanthin emulsion gel. The invention provides a preparation method of astaxanthin emulsion gel, which comprises the following steps: taking an ovalbumin and beet pectin compound solution obtained through electrostatic interaction under a specific pH value as a water phase, taking medium-chain fatty acid containing astaxanthin as an oil phase, and mixing the oil phase with the ovalbumin and beet pectin compound solution to obtain the astaxanthin emulsion gel. The preparation method comprises the following steps: carrying out homogenization treatment on a blend of a water phase and an oil phase by using a high-speed dispersion machine to obtain a primary emulsion, carrying out ultrasonic treatment on the primary emulsion to obtain an emulsion, adding calcium ions into the emulsion, uniformly mixing, and carrying out crosslinking and phase change on the emulsion to obtain the astaxanthin emulsion gel. According to the astaxanthin emulsion gel disclosed by the invention, the storage stability of the astaxanthin can be remarkably improved, so that more astaxanthin is migrated to a water phase in an intestinal digestion process, the bioavailability of the astaxanthin is improved, and the antioxidant activity in vivo is remarkably improved compared with that of free astaxanthin.

The invention provides mixed structure grease for promoting skeletal development and improving bone mineral density as well as a preparation method and application of the mixed structure grease. The mixed structure grease for promoting skeletal development and improving bone mineral density comprises the following components in percentage by mass: 2-10% of medium-chain fatty acid triglyceride, 10-50% of medium-long-chain fatty acid triglyceride and 40-90% of long-chain fatty acid triglyceride. The traditional Chinese medicine composition can effectively promote skeletal development and improve bone mineral density.

The invention belongs to the technical field of biochemical engineering, and particularly relates to a method for preparing medium-chain fatty glyceride through double-enzyme catalysis. The method provided by the invention comprises the following steps: firstly, catalyzing raw materials such as coconut oil to be completely hydrolyzed by utilizing lipase, and separating medium-chain fatty acid with the purity of more than or equal to 99.5% by adopting a molecular distillation cooling crystallization technology; then, high-purity fatty acid and glycerol are used as substrates, immobilized lipase is used as a catalyst, directional esterification is performed in a reactor provided with a dehydration membrane block, and the water activity of the system is controlled to be 0.1-0.3. The content of medium-chain fatty glyceride in the final product is higher than 98%, and the final product does not contain long-chain fatty acid impurities. The process is green and energy-saving, the catalyst can be recycled, the economical efficiency is good, and an innovative solution is provided for large-scale production of the high-purity structured lipid.

The present invention discloses a device and method for promoting the production of medium-chain fatty acids by anaerobic microorganisms. The device includes a device body, a sludge treatment chamber, an anaerobic microorganism chamber, a medium-chain fatty acid production chamber, and auxiliary components. The device body includes a housing, a rotating shaft is rotatably connected in the housing, a hollow groove is provided in the rotating shaft, an upper cover is installed on the housing, and a feed port is installed on the upper cover; the sludge treatment chamber includes a first sieve plate and a second sieve plate. The device provided by the present invention is an integrated device, in which all processes from sludge to medium-chain fatty acids can be completed, thereby simplifying the equipment for preparing medium-chain fatty acids, making the equipment occupy a smaller area, and reducing the procurement cost and use cost of the equipment, thereby reducing the cost of preparing medium-chain fatty acids. It has significant significance in the treatment of sludge, realizes resource recycling, effectively curbs the pollution of sludge to the environment, and has great promotion value.

The present invention relates to a pharmaceutical composition, a health-care functional food composition or a health-care functional food for preventing, treating or ameliorating sarcopenia, comprising at least one of one or more short-chain or medium-chain fatty acids, esters thereof or triglyceride forms thereof. Furthermore, the present invention relates to a composition for diagnosing a possible group of sarcopenia or a group of sarcopenia, comprising, as an active ingredient, an agent for measuring the content of one or more short-chain or medium-chain fatty acids in blood, and to a method of providing information for determining a possible group of sarcopenia or a group of sarcopenia comprising the step of measuring the content of one or more short-chain or medium-chain fatty acids from the blood of a subject.

The invention discloses an anthocyanin ingredient containing milk fat globules and a preparation method thereof.The preparation method comprises the specific steps that the milk fat globules are extracted from fresh raw milk, anthocyanin and the milk fat globules are added into deionized water to be emulsified, and the anthocyanin emulsion type ingredient containing the milk fat globules is obtained; wherein anthocyanin in the ingredients and a fat membrane of the milk fat globules form a specific structure, and the specific structure is rich in long-chain unsaturated fatty acid and medium-chain fatty acid in a specific ratio of 1: (7-10) after being digested by in-vitro simulated gastrointestinal fluid. The anthocyanin ingredient containing the milk fat globules is a novel stable emulsion taking the natural milk fat globules as an anthocyanin carrier, is particularly suitable for being used as an ingredient of nutritional and healthy food, and is wide in application range. And the preparation method adopts a probe type ultrasonic combined high-speed shearing technology, so that the obtained emulsion is better in dispersity and stability, simple, efficient, green and safe.

The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.

The invention belongs to the technical field of functional grease preparation, and discloses a preparation method and application of medium-chain and long-chain fatty acid triglyceride. The preparation method comprises the following steps: taking mixed vegetable oil; adding water and heating to obtain an oil-water mixture; filling the immobilized lipase into a glass column with external circulating water heating for preheating; injecting the oil-water mixture from the upper part of the immobilized enzyme column to carry out enzyme hydrolysis reaction; collecting a hydrolyzed oil crude product, and separating free fatty acid; taking medium chain triglyceride, mixing, and injecting into the immobilized enzyme column for esterification reaction; and removing reaction by-products to obtain the medium and long chain fatty acid triglyceride rich in omega-3 / 6 / 9 equilibrium proportion. The product prepared by the method contains medium-chain fatty acid and long-chain fatty acid at the same time, the proportion of different fatty acids is more balanced, the health requirement of a human body on fatty acid intake is met, the immobilized enzyme column technology is used in a solvent-free system, the steps of lipase and oil separation are simplified, the service life of enzyme is remarkably prolonged, and the method is suitable for industrial production. The energy consumption and pollution emission are reduced, the production cost is reduced, and the modern industrial green development concept is met.

An object of the present application is to provide a new composition for promoting ketogenesis. According to the present application, there is provided a composition for promoting ketogenesis containing one or two or more amino acids selected from the group consisting of citrulline, leucine, cysteine, taurine, glutamine and aspartic acid. The composition of the present application can further contain either or both of a medium-chain fatty acid and a medium-chain fatty acid ester.

The present application relates to methods and uses for inhibiting African swine fever virus and / or classical swine fever virus in animal feed or animal feed ingredients. The present invention provides a method of inhibiting African swine fever virus and / or classical swine fever virus in an animal feed or an animal feed ingredient, comprising: introducing a chemical slow-epidemic agent into the feed or feed ingredient, the chemical slow-epidemic agent comprising medium chain fatty acid and / or essential oil, wherein the chemical slow-epidemic agent is introduced at a content of from about 0.125% to less than 2% by weight based on the total weight of the animal feed or feed ingredient considered as 100% by weight. The chemical slow-epidemic agent is effective when introduced into a feed or feed ingredient at a much lower inclusion rate than existing methods for inhibiting other microorganisms. The method is particularly suitable for the post-processing of animal feed, feed ingredients or pet food for transportation and storage for several days or weeks.

The invention relates to chicken meal type micropterus salmoides feed and a preparation method thereof, and belongs to the technical field of aquatic feed. The feed comprises the following components in percentage by weight: 15-40% of chicken meal; 5-15% of fish meal; 10-30% of a plant protein source; 20-40% of an energy source; 0.3 to 1.5 percent of crystalline amino acid; 0.01%-0.5% of a composite antioxidant; and 1.5 to 5.5% of a functional additive. The core of the invention is to successfully solve the two technical bottlenecks of poor palatability and amino acid imbalance caused by high-proportion replacement of fish meal by chicken meal through systematic compatibility. Specifically, basic food calling performance is provided by retaining a specific proportion of fish meal; an ideal amino acid spectrum is remodeled by adding crystalline amino acids of specific types and proportions; fat oxidation and peculiar smell generation of the chicken powder are effectively inhibited by adopting a composite antioxidant system consisting of natural vitamin E, rosemary extract and medium-chain fatty glyceride.