The application discloses application of O-acyl-alpha-hydroxy acid compounds in
weight loss and lipid reduction, and belongs to the fields of biological
medicine manufacturing, biological
medicine use and
functional food development. The O-acyl-alpha-hydroxy acid compounds can inhibit
weight growth of high-
fat diet-induced obese model mice and reduce body fat. Compared with GLP-1
receptor weight loss drugs which achieve the effect of reducing weight by inhibiting
appetite, the O-acyl-alpha-hydroxy acid compounds are not dependent on
appetite inhibition, and can reduce side effects such as
gastrointestinal discomfort and
muscle loss caused by inhibiting
appetite. When combined or sequentially administered with GLP-1 drugs, the O-acyl-alpha-hydroxy acid compounds can maintain or enhance the
weight loss effect while improving the side effects caused by GLP-1, and can prevent the risk of significant weight rebound after stopping GLP-1 by maintaining
body weight. The application provides a safe and effective new strategy for weight loss and lipid reduction.