45results about How to "Reduce weight gain" patented technology

Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of an opioid antagonist such as nalmefene, naloxone or naltrexone or a mixture of any one of these, and either clonidine or related compounds either while awake, or while under sedation or anesthesia, followed by continued administration of an effective amount of an opioid antagonist with or without agents that enhance nicotine dependency treatment. Persons are also treated for nicotine dependency with more gradual detoxification methods using administration of a combination of an effective amount of an opioid antagonist such as nalmefene, naloxone, naltrexone, or a mixture of any of these, and an effective amount of agents used to treat nicotine withdrawal including nicotine, such as that delivered by a nicotine patch, nicotine chewing gum, nicotine inhaler or other methods for delivering nicotine, antidepressants and antianxiety agents, and/or clonidine and related compounds. Administration of an effective amount of an opioid antagonist to prevent relapse, attenuate craving, and reduce weight gain during and after treatment for nicotine dependency is continued in some embodiments.

Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.

Modified glucagon peptides are disclosed having improved solubility and/or half-life while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.

The present invention relates to certain substituted aryl and heteroaryl derivatives as shown in Formula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.

Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.

This invention is directed generally to compositions (including foods, supplements, treats, toys, etc.) for animal consumption, particularly compositions that tend to aid in weight loss or reduction in weight gain, and particularly compositions that comprise one or more medium chain fatty acid triglycerides (“MCT”). This invention also is directed generally to methods for using such compositions. This invention is further directed generally to processes for making such compositions.

The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and/or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.

The invention comprises use of a bacterium selected from a lactic acid bacterium, a Bifidobacterium and a mixture of any thereof in the manufacture of a food product, dietary supplement or medicament for lowering tissue inflammation (in particular, adipose, liver or muscle tissue inflammation) and treating cardiovascular disease in a mammal. The lactic acid bacteria and/or Bifidobacteria can also be used to treat diabetes and insulin resistance and induce enhanced secretion of insulin upon a glucose challenge and lower blood glucose levels without a concomitant decrease in weight gain.

The invention provides a feeding method for high-quality ecological special wild pigs. Health-care fodder, regular feeding, an ecological environment and healthy living are involved in the method. The health-care fodder is prepared from astragalus membranaceus, turmeric, honeysuckle, hawthorns, codonopsis, dandelion, licorice roots, corn, bran and green vegetables. According to the regular feeding, the health-care fodder is cooked thoroughly with water, feeding begins at 6-7 o'clock every day, feeding is carried out once every five hours, and feeding is carried out three times one day. According to the ecological environment, a fermentation bed is arranged on the rear half part of a pigsty or the outer side of the pigsty, and padding made of plant stalk powder, rice husks and microbial fermentation strains is laid in the fermentation bed. According to the health living, in the hot seasons, the pigs stay outdoors at 8-9 o'clock in the morning each day, and in other seasons, the pigs stay outdoors at 9-10 o'clock in the morning and 14-15 o'clock in the afternoon each day. The method is used for feeding the wild pigs, the pigs can be slaughtered in 12 months, the self immunity of the wild pigs is improved, anti-biotic drug residuals are avoided, the meat quality is good, the protein content is large, and the original ecology taste of wild pig meat is achieved.

The invention belongs to the field of health care products, and specifically relates to biscuits capable of cleansing colon, expelling toxin, maintaining beauty and keeping young and a preparation method thereof. The biscuits are prepared by raw materials including, by mass, 10-25% of oat powder, 10-15% of Chenopodium quinoa powder, 0.1-0.3% of resistant dextrin, 3-5% of coconut oil, 1-3% of plant stanol ester, 2-6% of chia seed powder, 1-3% of potato powder, 1-4% of white kidney bean powder, 1-3 % of whey protein powder, 0.02-0.05% of hydrolyzed yolk powder, 3-8% of psyllium husk powder, 1-3% of trehalose, and residual water. The biscuits can be used as meal replacement biscuits, have the characteristics of low calorie, high dietary fiber and high protein, and have mouthfeel of crisp biscuits, and animal tests have proved that the biscuits have a certain fat-reducing effect.

This invention is directed generally to methods and compositions (including foods, supplements, treats, toys, etc.) which are useful in preventing or reducing the formation of bezoar or trichobezoar in mammals.

The present invention relates to a composition for the prevention or treatment of diabetes including a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a method for treating diabetes. More specifically, combination administration of the long-acting analogue conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain due to administration of insulin, and vomiting and nausea due to administration of the insulinotropic peptide, and also reduces the required doses of insulin, thereby remarkably improving drug compliance. In addition, the present invention relates to administering a pharmaceutical composition for reducing side effects of pancreatic beta cells in diabetic patients, including a long-acting insulin analogue conjugate and a long-acting insulinotropic peptide analogue conjugate, and to a method for reducing side effects of pancreatic beta cells in diabetic patients, including the step of administering the composition. Specifically, the present invention is characterized in reducing side effects such as abnormality in the function of pancreatic beta cells associated with the development of diabetes, reduction in the pancreatic beta cell mass, lipotoxicity, or glucotoxicity.

The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.

Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.

The present invention belongs to pharmaceutical chemistry field. Paliperidone amino acids derivates and use thereof are disclosed After experiment, it is found that the compounds can be used for preparing medicant for treating mental diseases.

The present invention relates methods of reducing fecal shedding of animals infected with Salmonella by use of a vaccine or immunogenic composition of Salmonella Choleraesuis-Typhimurium.

The invention relates to a feeding method of meat lambs. The method includes the specific steps of 1, implementing the feeding method for lambs of 0-10 days old; 2, implementing the feeding method for lambs of 10-20 days old; 3, ablactating lambs of 20-25 days old completely. Experiments show that by adopting the method to feed meat lambs, the weight gaining speed of lambs is effectively increased on the premise of guaranteeing the survival rate of lambs, and thus the economic benefit of a farmer is greatly increased.

The invention discloses a culture method for ecological wild boars. The method comprises following steps: (1) health-care fodder; (2) ecological environment; (3) healthy living. The culture method for ecological wild boars has following beneficial effects: based on eating habits and nutrition demands, fodders can be arranged so that good palatability, high protein content, full amino acid and rich vitamin content are obtained; immunity and disease prevention of wild boars are obtained; in addition, though weight-gaining speed of wild boars may slow down due to indoor ventilation, physical health of wild boars is enhanced so that possibilities of injecting antibiotics due to diseases is reduced; regular feeding and healthy living are compatible with rhythm of biological clocks of wild boars; health degree of wild boars is improved so that quality is improved; an ecological environment can rapidly digest and decompose excreta such as manure such that hog houses are pollution-free and odor-free so that living quality of wild boars is improved.

The invention discloses a red date probiotics fermented feed additive. The additive is prepared from, by mass, 95% of whole red date powder, 2% of radix astragali, 2% of radix angelicae sinensis and 1% of herba leonuri through fermentation through a beneficial viable bacteria preparation. By sufficiently using the medicine and food homologous functions of tonifying spleen, nourishing stomach and tonifying qi and blood and the advantages of high energy, high sugar content and high vitamins of red dates, the feed palatability, livestock growth rate and immunity are greatly improved. A large amount of metabolisms are generated in the fermentation process, intestinal disorder can be quite well adjusted, and the supplementing of normal flora of intestines or the promoting of the proliferation of beneficial bacteria is realized; the beneficial flora generates hydrogen peroxide, organic acid, bactericidin and the like, so the growth and plantation of aerobic bacteria and foreign pathogens are not facilitated, the remarkable biological antagonism effect is realized on pathogenic bacteria, lots of beneficial flora is provided for the health of animal intestines, and therefore balance is reached.

The invention relates to the technical field of livestock breeding, in particular to a disease-resistant fattening breeding method for beef cattle. The method divides the breeding process of cattle into a plurality of different growth periods, adjusts the feed ingredients in different time periods, uses different traditional Chinese herbal medicine compatibilities to enhance the immunity and vitality of the cattle, and adopts different sports modes of the beef cattle in different time periods, thereby further enhancing the immunity and feed-to-meat ratio of the beef cattle. The method does notuse antibiotics and hormones in the whole process and does not affect the health of the cattle, the cattle bodies do not contain the antibiotics, and the method is a pure-natural disease-resistant fattening breeding method for the beef cattle.

The invention discloses a panoramic sunroof top cover assembly, and relates to the technical field of automobile body-in-white. The assembly includes a top cover outer board having a rectangular sunroof opening. A reinforcement board is welded under the top cover outer board near the rectangular sunroof opening. The reinforcement board is an integral sunroof reinforcement board. Reinforcement blocks are arranged on the four corners of the integral sunroof reinforcement board. Compared with the prior art, since the reinforcement blocks are arranged on the four corners of the integral sunroof reinforcement board, the stiffness of the four corner joint parts is improved, the torsional stiffness is maximized, the weight increase is reduced, and the cost waste is reduced.

The present invention relates to antioxidation technology, and is especially method of raising the medium temperature antioxidation performance of Ti3AlC2. Ti3AlC2 is treated in oxidizing atmosphere at 1000-1300 deg.c for 0.5-4 hr to preoxidize and the said oxidizing atmosphere is static or flowing air, oxygen or diluted oxygen. The said process can produce oxide layer well combined with the base body and without holes and cracks, and this can raise the medium temperature antioxidation performance of Ti3AlC2.

Non-naturally occurring thermogenic adipocytes are provided. The cells have a distinctive molecular signature, and can be distinguished from predecessor cells such as adipose-derived stem cells as well as other naturally occurring and induced thermogenic cells. Differentiation media that can induce differentiation of ADSC and white adipocytes into thermogenic adipocytes is also provided. Methods of making thermogenic adipocytes, thermogenic adipocytes made according the disclosed methods as well as conditioned media made according a method of incubating the cells in a tissue culture media are also provided. Compositions including thermogenic adipocytes, conditioned media, secreted factor(s), active agents that increase the number or activity of thermogenic adipocytes, or a combination thereof are also disclosed and can be used to treat a variety of diseases and conditions, particularly obesity and metabolic disorders.

The present invention is related to acyclic sulfamide derivatives, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulfamide derivatives are also useful for cosmetic use.

The invention relates to a combined determination method for calcium and chlorine contents in a solid sintering aid, which comprises the following steps: 1, sampling and preparing a sample, rapidly collecting a sintering aid sample by using a sampler, and carrying out sealed storage, 2, weighing the sample, rapidly weighing about 1g of the sample by using an electronic balance, and 3, decomposing the sample, heating by a proper amount of distilled water at low temperature to completely dissolve the sample, cooling and fixing the volume; 4, performing calcium content detection and partial sample solution separation; and 5, performing chlorine determination: taking part of the sample solution, titrating the solution by using a silver nitrate standard, titrating by using a potentiometric titrator, indicating an end point through potential mutation, and carrying out blank determination at the same time; 6, calculating a result. The calcium content in the sintering aid is determined by adopting an EDTA complexometric titration method, the chlorine content in the sintering aid is determined by adopting an automatic potentiometric titration method. The technical problem of rapid detection of the content of calcium and chlorine in the existing sintering aid for sintering production is mainly solved.