The invention belongs to the field of pesticides, and in particular relates to a herbicide composition containing Benzuofucaotong (4-(having a chemical formula name of 2-chloro-4-methanesulfonyl-3-(2,2,2-trifluoroethoxy)methyl)benzoyl-1-ethyl-1H-pyridin-5-yl-1,3-dimethyl-1H-pyridine-4-carboxylate) and application thereof. The herbicidal composition comprises a herbicidally effective amount of active ingredient A and active ingredient B, wherein the ingredient A is Benzuofucaotong, and the ingredient B is selected from one or more of the following compounds: VLCFA, PPO, PSII, ALS, microtubule assembly, HPPD, PDS, lipid synthesis, EPSPS, GS, PSI, DHP inhibitors and synthetic hormones. The composition can effectively control weeds in a crop field, such as descurainia sophia and malachium aquaticum, and has the characteristics of expanding the weed killing spectrum, reducing the application amount, being safe to crops, generating synergistic effects, and solving resistant weeds.