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This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices.

This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

An ultrasound catheter adapted for accessing small vessels in the distal anatomy is disclosed. The ultrasound catheter comprises an elongate tubular body formed with a delivery lumen. The flexibility and dimensions of the tubular body allow access to the distal anatomy by advancement over the guidewire. An ultrasound radiating member is provided along the distal end portion of the tubular body for emitting ultrasound energy at a treatment site. A drug solution may also be delivered through the delivery lumen and out an exit port to the treatment site.

An LED system that simulates bare or exposed neon in appearance. The curvilinear LED light source comprises a rigid, formable light guide having a generally circular cross-section and a flexible LED light engine. The light guide is made of a material or materials that can be heated and formed into a desired shape. The light guide retains the desired shape upon cooling. The flexible light engine is inserted into a groove in the light engine.

A medical instrument that utilizes electrical energy delivery between first and second opposing polarity electrodes in an interior bore of a working end to cause vaporization of an inflowing fluid media. The vaporization and expansion of the fluid media creates pressure gradients in the working end that causes heated vapor to propagate distally from the working end. The propagation or jetting of the vapor media is used to controllably cause thermal effects in endoluminal environments. The instrument and method can be used to shrink and occlude blood vessels in a treatment for varicose veins.

Improved memory devices, circuitry, and data methods are described that facilitate the detection and correction of data in memory systems or devices by encoding the data bits of a memory row or block in a non-systematic ECC code. This allows memory embodiments of the present invention to utilize reduced complexity error detection and correction hardware and / or routines to efficiently detect and correct corrupted user data in a segment of memory, such as a sector, word line row, or erase block. Additionally, in embodiments of the present invention user data is not stored in a plaintext format in the memory array, allowing for an increased level of data security. Further, in embodiments of the present invention, the ECC code is distributed throughout the stored data in the memory segment, increasing the robustness of the ECC code and its resistance to damage or data corruption.

A composite panel structure for an aircraft includes a plurality of annular, hat-shaped frames disposed coaxially along a long axis of the aircraft in a spaced, parallel relationship, an inner skin having an inner surface bonded to an outer surface of the hat frames, a plurality of elongated, hat-shaped stringers disposed in a longitudinal direction along an outer surface of the inner skin in a spaced, parallel relationship, a solid or rigid foam offset bonded to an outer surface of each of the stringers, and an outer skin having an inner surface bonded to an upper surface of each of the offsets. The inner skin carries the loads of the structure and the outer skin defines an aerodynamic surface of the aircraft and provides impact and lighting protection. The frames, inner skin and stringers are formed on a single forming tool and cured and bonded with each other simultaneously.

The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a T cell expressing said TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.

The present invention is directed to a high density electrical connector which can provide 80 or more twinax connections per linear inch in a 20 millimeter card slot. In a typical electronic system package, 20 millimeters is the spacing from center line to center line of the adjacent parallel daughtercards. Twinax cable is coaxial cable that contains two inner conducting wires rather than one. The two inner conducting wires provide two physical channels. Coaxial cable is called “coaxial” because it includes one physical channel that carries the signal surrounded (after a layer of insulation) by another concentric physical channel, both running along the same axis. The outer channel serves as ground.

To more accurately control insertion of penetrating instruments (e.g., trocars, needles, or the like) into a body cavity, organ, or potential space, an accelerometer is coupled to the penetrating instrument. The accelerometer may by employed to measure or detect the sudden lack of resistance which occurs when the penetrating instrument penetrates to a predetermined depth (e.g., through the abdominal cavity, vein, or outer bone) in a more accurate and reliable way instead of practitioners' subjective feeling. An acceleration sensor (i.e., accelerometer) coupled to the penetrating instrument (e.g., trocar or the like) may transform the physical variable ‘resistance change’ into an electronic signal that is then processed in an electronic circuit, and finally triggers an audible / visible alarm and / or feeds an actuating mechanism to control movement of the penetrating instrument.

Compositions and methods in which dry-committed fibers are substantially homogeneously dispersed throughout a fibrous composition. The fibrous composition is characterized as having sufficient yield stress and viscosity such that the shearing forces from the mixing apparatus are effectively transferred down to the fiber level. This is accomplished by means of an appropriate thickening agent, e.g, gelatinized starch. The dry-committed fibers are exemplified by flash dry fibers or fibrous sheets that have been cut or torn into fragments less than 2 cm across. Providing fibers that have been dry-committed greatly reduces the time that it takes to obtain substantially homogeneous dispersion of the fibers throughout the fibrous composition. This, in turn, reduces the risk of mixture spoilage and mechanical or chemical damage to the solid components within the fibrous composition.

A catheter that is produced in which magnetic powder is commingled and becomes an integral part of the catheter, which makes it not only guidable within the body by an external device, but can be made to vibrate at various speeds (cycles per second) and at varying intensities (voltages) to not only prevent its adhesion to vascular walls, but to render plaque into a viscous state, for easy suctioning from the body.

An antenna system that is insensitive to the surface on which it is mounted for use with a RFID tag having a wireless communication device, including a plurality of conductive tabs coupled to the wireless communication device for receiving and radiating radio frequency energy. At least two of the tabs are substantially identical in shape and coupled to the wireless communication device at feedpoint differing in location on each of the two tabs wherein the width of said at least two of said plurality of tabs taken transverse to the longitudinal centerline axis of each tab varies with distance along the longitudinal centerline axis of each of said tabs from its feedpoint. Alternatively, the wireless communication device is coupled to the tab at a feedpoint selected at a location differing on each of the tabs where the conducting area per unit length of the longitudinal centerline axis of each tab varies with distance along the longitudinal centerline axis of each of said tabs from its feedpoint. A radio frequency reflecting structure is coupled to the conductive tabs for reflecting radio frequency energy radiated therefrom. A dielectric material is located intermediate the conductive tabs and the radio frequency reflecting means.

The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and / or diagnostics.

A plasma processing apparatus comprising: a process chamber for defining a plasma processing space in which a substrate holder for mounting a substrate thereon is installed; a plasma chamber in communication with an upper portion of the process chamber to generate and inject plasma into the plasma processing space such that the substrate is processed; a screen interposed between the process chamber and the plasma chamber to block plasma ions from being injected from the plasma chamber; and an ion trap for protecting the surface of the substrate from damage due to the injected plasma ion.

A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams / microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.

A light-emitting diode (LED) lighting tube is of a disassembleable structure, which arranges those components that are susceptible to easy damage in an end cap that is located at an outer side. Thus, when the lighting device is malfunctioning, it only needs to replace the end cap module that is located at the outer side to resume normal operation of the lighting tube. Parts of long lifespan of the lighting tube are preserved so that the costs are reduced and the tread of environmental protection is met.

A method of performing microbeam radiation therapy (MRT) includes delivering a dose only to selected tissue in a target volume (10) with continuous broad beam, first, by interleaving arrays of microplanar beams (30,36) only at the target (10). Administered contrast agents can supplement the effect by preferentially increasing the target dose relative to dose in normal tissue. A broad beam effect is alternatively created using non-interleaving microbeam array(s) with scattering agents administered to selected tissue that preferentially increase valley dose (69) within target to approximate broad beam. The methods of interleaving microbeams are also applied to treat diseases and conditions by ablating at least a portion of selected tissue, or by damaging blood-brain barrier for efficient drug and / or cell administration. A system for performing interlaced microbeam radiosurgery preferably includes two orthogonal radiation source arms (102) for producing and interleaving microbeam arrays (30,36) at the target volume (10). The methods treat tumors, pain, epilepsy, and neurological diseases.

High-molecular compounds comprising repeating units represented by the general formula (1) or (2) and having number-average molecular weights of 103 to 108 in terms of polystyrene: (1) [wherein Ar1 and Ar2 are each independently a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group; and X1 and X2 are each independently O, S, C(═O), S(═O), SO2, C(R1)(R2), Si(R3)(R4), N(R5), B(R6), P(R7), or P(═O)(R8), with the provisos that X1 and X2 must not be the same and that X1 and Ar2 are bonded respectively to the adjacent carbon atoms constituting the aromatic ring of Ar1, and X2 and Ar1 are bonded respectively to the adjacent carbon atoms constituting the aromatic ring of Ar2] (2) [wherein Ar3 and Ar4 are each independently a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group; and X3 and X4 are each independently N, B, P, C(R9), or Si(R10), with the provisos that X3 and X4 must not be the same and that X3 and Ar4 are bonded respectively to the adjacent carbon atoms constituting the aromatic ring of Ar3, and X4 and Ar3 are bonded respectively to the adjacent carbon atoms constituting the aromatic ring of Ar4].

A light-emitting device includes a base; a plurality of first electrodes; a partition having a plurality of openings located at positions corresponding to the first electrodes; organic functional layers each arranged in the corresponding openings; a second electrode covering the partition and the organic functional layers; an organic buffer layer covering the second electrode; a gas barrier layer covering the organic buffer layer; and an intermediate protective layer, disposed between the organic buffer layer and the gas barrier layer, having an elasticity which is greater than that of the organic buffer layer and which is less than that of the gas barrier layer. These layers and electrodes are arranged on or above the base.

A spoolable composite tube capable of being spooled onto a reel for storage and for use in oil field applications. The spoolable tube exhibits unique anistropic characteristics that provide improved burst and collapse pressures, increased tensile strength, compression strength, and load carrying capacity, while still remaining sufficiently bendable to be spooled onto a reel in an open bore configuration. The spoolable composite tube can include an inner liner, an interface layer, fiber composite layers, a pressure barrier layer, and an outer protective layer. The fiber composite layers can have a unique triaxial braid structure.

A building roof tie for attaching roof trusses and rafters to wood top plates in building structures, such roof tie having a sheet metal body with risers and a bridge for overlapping a rafter and flaps for wrapping on the sides of the top plate. A generally triangular shaped reinforcing wing provides strength and stability, and can also provide additional hold-down strength, allowing the roof tie to be manufactured from different weights of steel. Turnbuckles attached to the bridge provide additional hold-down strength against increased uplift forces. The roof ties are pitched to conform to a variety of framing applications. A plurality of apertures is formed in the roof tie to provide openings for fasteners for connecting the tie to the wood top plate and rafter.

An instantaneous current and instantaneous voltage of a three-phase coil of a brushless DC motor are detected, and the internal condition of a compressor is predicted from these detection values. The prediction about the internal condition of the compressor is made in such a way that motor driving torque which is a parameter of a motor model is identified and poor lubrication, liquid compression or the like is predicted from this identified motor driving torque. This enables it to make, in real time, a failure forecast, failure diagnosis etc. on the compressor.