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60 results about "Immunomodulatory peptide" patented technology

Flagellin polypeptide vaccines

Vaccines that comprise or generate immunomodulatory flagellin polypeptides able to stimulate an innate immune response intracellularly and extracellularly employ viruses, bacteria or parasitic cells that contain expression systems for such polypeptides, as well as fusion proteins that contain antigens and / or cell penetrating peptides along with the immunomodulatory peptide.
Owner:INSTITUTE FOR SYSTEMS BIOLOGY

Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof

ActiveUS20050191296A1Facilitates the binding of a B7-2 ligandEliciting protective immunity against toxic shockCell receptors/surface-antigens/surface-determinantsImmunoglobulins against cell receptors/antigens/surface-determinantsAntigenBacterial exotoxin
Disclosed are methods and compositions for the inhibition of modulation of T cell costimulatory pathway by a pathogenic agent, particularly, the inhibition of activation of a T cell costimulatory pathway, preferably, the CD28 / B7 pathway, by a pyrogenic exotoxin. The method of the invention is based on the inhibition of the direct interaction of a superantigen with a specific site within the dimer interface of a CD28 family member, using immunomodulatory peptides. Further disclosed are specific antagonist immunomodulatory peptides comprising an amino acid sequence derived from a dimer interface of a T cell co-stimulatory pathway member, or peptides which comprise an amino acid sequence which specifically binds to an amino acid sequence within the dimer interface of a T cell co-stimulatory pathway member. Compositions comprising said peptides and methods for the treatment of immune-related disorders are also disclosed. Also disclosed is the use of the CD28 molecule or any fragment thereof comprising the sAg binding site in a method of screening for a test substance which specifically binds to the CD28 molecule and is capable of antagonizing pyrogenic exotoxin-mediated activation of Th1 lymphocytes.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD

Immune-modulating peptide

Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
Owner:POSTECH ACAD IND FOUND

Compositions and methods for in vitro activation and expansion of serial killer t cell populations and passive immunization of a cancer patient with tumor cell killing cells

The described invention provides a method for in vitro immunoactivation of mononuclear cells by contact with one or more populations of engineered leukocyte stimulator cells genetically engineered to express a core of 3 essential immunomodulator peptides, and optionally additional R immunomodulator peptides, and use of a cell product comprising the expanded and activated mononuclear cell population comprising one or more subpopulations of cytotoxic serial killer cells for passive immunization of a cancer patient not currently under the influence of an immunosuppressive regimen.
Owner:ALLOPLEX BIOTHERAPEUTICS

Methods and compositions for modulating the imune system

Methods and compositions for cell therapy using immune modulating peptides comprising a manf family protein, or fragment thereof, as an adjuvant to improve replacement cell viability and integration. The methods and compositions can be used in the treatment of a variety of diseases and disorders, including retinal diseases.
Owner:THE BUCK INST FOR RES ON AGING

Immunostimulatory oligonucleotides with modified bases and methods of use thereof

Immunomodulatory oligonucleotide compositions are disclosed. These oligonucleotides comprise an immunostimulatory hexanucleotide sequence comprising a modified cytosine. These oligonucleotides can be administered in conjunction with an immunomodulatory peptide or antigen. Methods of modulating an immune response upon administration of the oligonucleotide comprising a modified immunostimulatory sequence are also disclosed.
Owner:DYNAVAX TECH CORP

Periplaneta americana immunomodulating peptide and preparation method and medical application thereof

The invention relates to a periplaneta americana immunomodulating peptide and a preparation method and medical application thereof. Specifically, the invention relates to an immunomodulating peptide which is extracted from periplaneta americana and has the effects of preventing and treating tumor diseases and improving the immunity function of an organism. The polypeptide substance is a single chain polypeptide of which the amino acid sequence is arginine-arginine-asparagine-leucine-leucine-alanine-alanine-serine-leucine-leucine-asparagine- aspartate, and is prepared by extracting fresh or dry periplaneta americana in water or an organic solvent and a buffer solution and refining through a membrane separation method and an HPLC (High Performance Liquid Chromatography) technology. The immunomodulating peptide has remarkable antitumor activity and immunomodulating effect, and can be used to make medicaments for preventing and treating tumor diseases and / or modulating immunity, daily chemical products or medical devices.
Owner:DALI UNIV

Preparation method of fish skin immunomodulatory peptides of Japanese croakers

The invention relates to the technical field of preparation of polypeptides of Japanese croakers and particularly relates to a preparation method of fish skin immunomodulatory peptides of Japanese croakers. The preparation method comprises the following steps: performing degreasing on fish skin by lipase combined with isopropanol to eliminate the bitter taste of immunomodulatory peptides; then, treating the fish skin through tartaric acid, a pulsed electric field and a reductive amination reagent to weaken the crosslinking degree among fish skin molecular proteins and enhance the swelling of the fish skin proteins; dissolving out the fish skin proteins in the fish skin as much as possible by virtue of the action of papain, chymotrypsin, trypsin, aspergillus serine protease or / and alkali protease and other protein extraction enzymes with weaker decomposition effect on the fish skin proteins at the temperature of 50-60 DEG C; and then, decomposing the fish skin proteins by virtue of thecombined action of neutral protease and neutral metal protease to obtain the fish skin immunomodulatory peptides. The utilization ratio of the fish skin proteins is high, the chain breaking decomposition uniformity is high, and the molecular weight of the obtained immunomodulatory peptides is 2000-3500Da.
Owner:ZHEJIANG OCEAN UNIV

Immunoregulatory peptides and methods of use

Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptors. Experiments are described illustrating the efficacy of the compounds in treating otitis media.
Owner:13THERAPEUTICS

Immune-modulating peptide

Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
Owner:POSTECH ACAD IND FOUND

Yao horsefly salivary gland immunoregulation peptide, gene and application thereof

The invention relates to a salivary gland immunoregulation polypeptide of a dieu cleg and the related genes and the application, belonging to the biomedical field. The immunoregulation polypeptide is a linear polypeptide coded with the Chinese Tabanidae salivary gland immunoregulation polypeptide genes, the sequence of which is glycin- glycin- valine- serine- glycin- valine- serine- aspartic acid- phenylalanine- glutamate- praline- isoleucine- glutamate- valine- serine- glycin- glutamate- aspartic acid- tyrosine- aspartic acid- serine- aspartic acid- glutamate- alanine- aspartic acid- glutamate- aspartic acid- glycin- lysine- alanine. The immunoregulation polypeptide gene is composed of 362 Nucleotides, wherein, the coding mature code salivary gland immunoregulation polypeptide of the dieu cleg is the 115th to the 204th nucleotide. The dieu cleg salivary gland immunoregulation polypeptide is used for inhibiting a plurality of cytokines, which is characterized by simple structure, convenient artificial synthesis and strong antibacterial activity, etc.
Owner:KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI

Goat whey protein immunoregulation peptide as well as preparation method and application thereof

The invention provides goat whey protein immunoregulation peptide. The goat whey protein immunoregulation peptide contains at least one peptide sequence of Thr-Gly-Pro-Ile-Pro-Asn-Ser-Leu, Arg-Phe-Phe-Asp-Asp-Lys-Ile-Ala and Ala-Pro-Glu-Pro-Glu-Val-Phe. The goat whey protein immunoregulation peptide is obtained from goat whey protein, and the raw materials are easily available; the goat whey protein immunoregulation peptide has very obvious promotion effect on the proliferation activity of spleen lymphocyte, shows certain dose dependent effect and has immunoregulation effect. The invention also discloses a preparation method of the goat whey protein immunoregulation peptide. The preparation method has simple steps; two kinds of protease (pepsase and trypase) are combined to hydrolyze the goat whey protein, so that active peptide fragments can be released well; the goat whey protein hydrolysate is separated and purified by a gel chromatographic column and high-performance liquid chromatography, and the purity of the product is higher. The invention also provides application of the goat whey protein immunoregulation peptide. The goat whey protein immunoregulation peptide is applied to preparation of food or health-care food with immunoregulation activity, and has wide application prospect.
Owner:HYPROCA NUTRITION CO LTD

Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof

ActiveUS8535672B2Facilitates the binding of a B7-2 ligandEliciting protective immunity against toxic shockCell receptors/surface-antigens/surface-determinantsImmunoglobulins against cell receptors/antigens/surface-determinantsAntigenDimer
Disclosed are methods and compositions for the inhibition of modulation of T cell costimulatory pathway by a pathogenic agent, particularly, the inhibition of activation of a T cell costimulatory pathway, preferably, the CD28 / B7 pathway, by a pyrogenic exotoxin. The method of the invention is based on the inhibition of the direct interaction of a superantigen with a specific site within the dimer interface of a CD28 family member, using immunomodulatory peptides. Further disclosed are specific antagonist immunomodulatory peptides comprising an amino acid sequence derived from a dimer interface of a T cell co-stimulatory pathway member, or peptides which comprise an amino acid sequence which specifically binds to an amino acid sequence within the dimer interface of a T cell co-stimulatory pathway member. Compositions comprising said peptides and methods for the treatment of immune-related disorders are also disclosed.Also disclosed is the use of the CD28 molecule or any fragment thereof comprising the sAg binding site in a method of screening for a test substance which specifically binds to the CD28 molecule and is capable of antagonizing pyrogenic exotoxin-mediated activation of Th1 lymphocytes.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD

R. grahami rnmunoregulating polypeptide, gene and variant and its application in medicine production

The invention relates to an Odorrana grahami immunomodulation peptide, gene and variant and the application in the pharmacy belonging to the biomedicine field. The Odorrana grahami immunomodulation peptide is a circular peptide with a molecular weight of 1791.12 D and a isoelectric point of 9.84. The whole sequence of the Odorrana grahami immunomodulation peptide is Thr Ser Arg Cys Tyr Ile Gly Tyr Arg Arg Lys Val Val Cys Ser (TSRCYIGYRRKVVCS), wherein the fourth cysteine and 14th cysteine form intramolecular disulfide bond. The code gene is composed of 307 nucleotides, wherein the code mature parts are from 141th to 186th nucleotide. The produced variant is produced by substituting the fourth amino acid in the original sequence of the Odorrana grahami immunomodulation peptide. The artificial synthetic Odorrana grahami immunomodulation peptide and variant thereof has a strong immunomodulation activity and tumor resistance activity and can be used for immunomodulation, tumor treatment and chemotherapeutics. The invention has the advantages such as simple sequence and convenient synthesis.
Owner:KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI

Efficient preparation method of low-value fish immunomdodulating peptides

The invention discloses an efficient preparation method of low-value fish immunomdodulating peptides, relates to the development and utilization of low-value fish bioactive peptides and related anti-inflammatory drug products, and belongs to the technical field of low-value fish processing; the preparation method comprises the steps of preparing nemipterus virgatus myosin by a salt extraction method, fully expanding a high-spiral structural domain of myofibrillar protein by using a high-pressure homogenization method; fine-tuning a protein solution to pH 7.5, adding trypsin, performing enzymatic hydrolysis for 90 minutes, promoting an ultrafiltration membrane to separate a nemipterus virgatus protein enzymatic hydrolysate by using impressed current, and obtain a peptide fragment of 500 to3000 components; finally obtaining a powdery product by a freeze-drying method; the method can improve the degree of hydrolysis of the nemipterus virgatus myosin peptide, and the biological propertiesand yield of the immunomodulating peptides; the anti-inflammatory activity of the immunomodulatory peptides prepared by the method is better; the invention realizes the deep processing and comprehensive utilization of the low-value fish, and has important meaning for improving the added value of the low-value fish.
Owner:FUJIAN AGRI & FORESTRY UNIV

Immunoregulation peptide, and preparation method and application thereof

InactiveCN104530212AStimulates the proliferation of T lymphocytesLow immunityMilk preparationPeptide/protein ingredientsImmunomodulatory peptideMedicine
The invention belongs to the fields of medicine and bioengineering, and discloses an immunoregulation peptide, and a preparation method and application thereof. The amino acid sequence of the immunoregulation is disclosed as SEQ ID NO:1. The immunoregulation peptide has high T lymphopoiesis promoting function, and can be used for preparing T lymphopoiesis promoting drugs.
Owner:NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL

Compound based on tuna activity extract and preparation method of compound

The invention discloses a compound based on a tuna activity extract. The compound comprises the components of the tuna activity extract and immune adjusting peptide, wherein the addition quantity of the immune adjusting peptide is 0.5-1wt% of the weight of the tuna activity extract, and the tuna activity extract is prepared through the steps of fishy smell elimination, fat elimination and neutral protease hydrolysis. The compound based on the tuna activity extract disclosed by the invention has the beneficial effects that the antioxidant activity is high, free radicals in human bodies can be removed, fat oxidization can be restrained, cells can be protected from being harmed by the free radicals, and the functions of the human bodies can be protected; raw materials are from tuna scraps, so that resource waste is avoided, the added value of low-value fish products can be increased, the raw materials belong to purely natural extracts, and damage cannot be caused to the health of the human bodies; the signal transduction system of immunocyte can be adjusted, the immunity of the human bodies can be adjusted, and the compound is easy to absorb and digest, good in mouth feel and free from fishy smell; and full-automated operation can be designed, and the production efficiency is high.
Owner:新昌县瑞天食品科技有限公司

Immunoregulatory peptides and methods of use

Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptors. Experiments are described illustrating the efficacy of the compounds in treating otitis media
Owner:13THERAPEUTICS INC

Dual-function polypeptide having effects of reducing blood sugar and regulating immunity and use of dual-function polypeptide

The invention relates to dual-function polypeptide having effects of reducing blood sugar and regulating immunity and the use of the dual-function polypeptide, and belongs to the technical field of biochemical pharmacy. The dual-function polypeptide is combined polypeptide of blood sugar reducing polypeptide and immunity regulating polypeptide, and flexible connecting peptide is arranged or is notarranged between the blood sugar reducing peptide and the immunity regulating peptide. The dual-function polypeptide having effects of reducing blood sugar and regulating immunity has the function ofa GLP-1 analog, promotes proliferation of pancreatic beta cells, reduces the blood sugar of a patient suffering from type I diabetes and reduces saccharification hemochrome, reduces blood sugar of apatient suffering from type II diabetes, restrains feeding and reduces saccharification hemochrome, also has the functions of immunity regulating peptide of autologous antigen of the type I diabetes,regulates immunity, and restrains pathological immunity attack.
Owner:NANJING ZERO TO ONE BIOTECH CO LTD

Shellfish feeding bait and method for reducing heavy metals in shellfish bodies

The invention relates to the technical field of preventing and governing of heavy metals contamination, and discloses a shellfish feeding bait and a method for removing heavy metals in shellfish bodies. The shellfish feeding bait disclosed by the invention comprises banana stalk cellulose esters, modified chitin, microalgae fragments and immune modulating peptide, wherein a complicated three-dimensional net structure can be formed among the banana stalk cellulose esters, the modified chitin, the microalgae fragments and the immune modulating peptide. Through the adoption of the shellfish feeding bait, the effect of reducing heavy metal is good, metabolisms of shellfish can be promoted, and the speed that heavy metal ions are discharged out of bodies of the shellfish can be accelerated. Themethod for reducing heavy metals in shellfish bodies through the shellfish feeding bait disclosed by the invention is simple; and after the shellfish feeding bait is recovered, through repeated desorption circulation, the shellfish feeding bait can still maintain higher activity.
Owner:ZHEJIANG OCEAN UNIV

Peptide feedstuff additive for regulating immunity function of sea water fish

The invention discloses peptide feed additive used to modulate the immune functions of seawater fish. The peptide feed additive consists of three or more than three types in peptide which is produced by enzymatic hydrolysis of cod fish, skin and internal organs with the molecular weight ranges respectively 100Da to 500Da, 500Da to 1500Da, 1500Da to 3000Da, 3000Da to 5000Da, and 5000Da to 8000Da. 1 percent to 5 percent of immune modulator of the invention is added into feed, which can obviously improve the level of IgM and muramidase in the serum of the seawater fish; the immune modulator of the invention can also improve the liver SOD level of the cultivated fish, thereby improving the oxidation resistant capability of the cultivated fish. The immune modulating peptide feed additive of the invention can also obviously improve the daily weight gain of the fish and reduce the liver index. The peptide feed additive used to modulate the immune functions of the seawater fish is safe without public harm, and the fish cultivated by the additive meet the green food sanitation requirements.
Owner:ZHEJIANG UNIV +2

Method for preparing nibea japonica scale immunomodulating peptide

The invention relates to the technical field of immunomodulating peptide preparation, aims to solve the problem of insufficient proteolysis in fish scales, and discloses a method for preparing nibea japonica scale immunomodulating peptides. The method for preparing the immunomodulating peptides comprises the following steps: firstly, putting fish scales into a sodium hydroxide alkali solution to remove viscous substances on surfaces of the fish scales, fat of the fish scales and other impurity substances, soaking into hydrochloric acid to remove calcium, further carrying out enzymolysis on proteins in the fish scales, and finally carrying out ultrafiltration, nanofiltration and drying in sequence, thereby obtaining the immunomodulating peptides. By adopting the method, bone bed ash contents are decomposed and damaged by using hydrochloric acid, and the proteins in the fish scales are out of protection of the bone bed ash contents, so that the enzymolysis efficiency of papain upon the proteins in the fish scales is greatly improved, the proteins in the fish scales can be subjected to sufficient enzymolysis, and the yield of the immunomodulating peptides can be increased.
Owner:ZHEJIANG OCEAN UNIV

Immunomodulatory peptides derived from heat shock proteins and uses thereof

InactiveUS7301005B2Modulate immune responseReduction and inhibition of inflammatory responseFungiBacteriaArthritisT cell
A method of modulating an immune response in a subject is disclosed. The invention is based on the discovery that an effective therapeutic strategy for ameliorating the inflammation-related symptoms of an immune-mediated disease, such as arthritis, can be achieved by modulation of the underlying immune response itself, rather than by merely addressing the resulting inflammation. This strategy can be used to regulate the inflammatory response and is applicable to a variety of contexts in which immune modulation is desired, such as mucosal tolerization, DNA vaccination, anergy induction, active immunization, and ex vivo modulation of antigen-specific T cells. In one embodiment, the method comprises administering to the subject a bacterial dnaJ peptide or a human homolog or a non-homologous human isoform thereof.
Owner:ALBANI SALVATORE +3

Preparation method and application of LGG fermentation product containing immunomodulatory peptide functional components

The invention provides a preparation method and application of an LGG fermentation product containing immunomodulatory peptide functional components. The method adopts lactobacillus rhamnosus LGG as asingle fermentation strain, and comprises the following steps: a, pretreatment of a fermentation substrate; b, adding of a carbon source; c, adding of a nutritional factor; d, homogenizing and sterilizing; e, an inoculation; f, fermenting and post-fermenting; g, a post-treatment so as to obtain a fermented liquid or powder of functional components such as immunomodulatory peptide of which the amino acid series is Thr-Thr-Met-Pro-Leu-Trp, morphine-like peptide of which the amino acid series is Tyr-Pro-Phe-Pro, P40 protein, P75 protein and the like. The fermentation product can be widely applied to various fresh or heat-treated foods, health-care products, special medical foods and even medicines, the health value of the foods is improved, and the health level of eaters is improved.
Owner:HEBEI FERMENT BIOLOGICAL TECH CO LTD

Method for preparing tilapia mossambica skin immunomodulating peptide

The invention relates to the technical field of preparation of immunomodulating peptides and discloses a method for preparing a tilapia mossambica skin immunomodulating peptide for solving the problemthat human health is damaged by heavy metals contained in the fish skin. The method for preparing the immunomodulating peptide comprises the following steps: cleaning the skin, and removing heavy metals and impurity particles in the skin by using an adsorbent; degreasing the skin with absolute ethyl alcohol, removing impure proteins in the skin by utilizing sodium hydroxide, performing enzymolysis on the skin by using papain, filtering, and performing freeze drying, thereby obtaining the immunomodulating peptide. According to the method disclosed by the invention, the skin is adsorbed in advance, and the heavy metals in the skin are removed, so that the prepared immunomodulating peptide does not contain any heavy metal damaging the human health.
Owner:湖北健肽生物科技有限公司

Preparation method of anglerfish skin peptides, and immunoloregulation application of prepared anglerfish skin peptides

The invention relates to the technical field of anglerfish skin peptides, and provides a preparation method of the anglerfish skin peptides to solve the problems of large molecular weight and bitter and fishy taste of polypeptides prepared from marine fish. Anglerfish skins are degreased by cooperating lipase with isopropanol, high-temperature calcined mussel powder is used to deodorize the degreased anglerfish skins and synergistically remove the bitter taste of the immunoloregulation peptides, an acidic environment, a pulsed electric field and sodium borohydride or sodium borohydride acetatecooperate with each other to weaken the cross-linking degree of the fish skin proteins and enhance the swelling of the fish skin proteins, the fish skin proteins are separated and extracted by a protein extracting enzyme having a weak decomposition effect on the fish skin proteins, and the fish skin proteins are decomposed by a highly-specific protease to prepare the anglerfish skin peptides. Theproportion of the anglerfish skin peptides having a molecular weight of 1000-3500 Da is high; and compared with fish skin proteins, the fish skin peptides have the advantages of high yield reaching about 78 wt%, uniform molecular weight, no bitter or fishy taste, high fish skin utilization rate and high immune activity, and can be applied to immunoloregulation.
Owner:ZHEJIANG OCEAN UNIV
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