59 results about "Immunomodulatory peptide" patented technology

Vaccines that comprise or generate immunomodulatory flagellin polypeptides able to stimulate an innate immune response intracellularly and extracellularly employ viruses, bacteria or parasitic cells that contain expression systems for such polypeptides, as well as fusion proteins that contain antigens and / or cell penetrating peptides along with the immunomodulatory peptide.

A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided.

This invention provides compositions and methods for stimulating the immune system. Such methods include administering an extract, purified peptide-linked glucan or active component thereof from Coriolus versicolor. The methods are particularly useful for prophylactic and therapeutic treatment of secondary immunodeficiency, wherein the immunodeficiency is the result of an infection, a malignant neoplastic disease, an autoimmune disease, a protein losing state, an immunosuppressive treatment, surgery or anesthesia.

Methods and compositions for cell therapy using immune modulating peptides comprising a manf family protein, or fragment thereof, as an adjuvant to improve replacement cell viability and integration. The methods and compositions can be used in the treatment of a variety of diseases and disorders, including retinal diseases.

Immunomodulatory oligonucleotide compositions are disclosed. These oligonucleotides comprise an immunostimulatory hexanucleotide sequence comprising a modified cytosine. These oligonucleotides can be administered in conjunction with an immunomodulatory peptide or antigen. Methods of modulating an immune response upon administration of the oligonucleotide comprising a modified immunostimulatory sequence are also disclosed.

Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptors. Experiments are described illustrating the efficacy of the compounds in treating otitis media.

Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.

Disclosed are methods and compositions for the inhibition of modulation of T cell costimulatory pathway by a pathogenic agent, particularly, the inhibition of activation of a T cell costimulatory pathway, preferably, the CD28 / B7 pathway, by a pyrogenic exotoxin. The method of the invention is based on the inhibition of the direct interaction of a superantigen with a specific site within the dimer interface of a CD28 family member, using immunomodulatory peptides. Further disclosed are specific antagonist immunomodulatory peptides comprising an amino acid sequence derived from a dimer interface of a T cell co-stimulatory pathway member, or peptides which comprise an amino acid sequence which specifically binds to an amino acid sequence within the dimer interface of a T cell co-stimulatory pathway member. Compositions comprising said peptides and methods for the treatment of immune-related disorders are also disclosed.Also disclosed is the use of the CD28 molecule or any fragment thereof comprising the sAg binding site in a method of screening for a test substance which specifically binds to the CD28 molecule and is capable of antagonizing pyrogenic exotoxin-mediated activation of Th1 lymphocytes.

Disclosed are methods and compositions for the inhibition of modulation of T cell costimulatory pathway by a pathogenic agent, particularly, the inhibition of activation of a T cell costimulatory pathway by a pyrogenic exotoxin. The direct interaction of a superantigen with a specific site within the dimer interface of a CD28 family member is inhibited using immunomodulatory peptides. Specific antagonist immunomodulatory peptides comprise amino acid sequences derived from a dimer interface of a T cell co-stimulatory pathway member, or peptides which comprise an amino acid sequence which specifically binds to an amino acid sequence within the dimer interface of a T cell co-stimulatory pathway member. Compositions comprising said peptides and methods for the treatment of immune-related disorders are also disclosed. Such molecules may be used in screening for a test substance which specifically binds to the CD28 molecule and is capable of antagonizing pyrogenic exotoxin-mediated activation of Th1 lymphocytes.

The invention discloses a compound based on a tuna activity extract. The compound comprises the components of the tuna activity extract and immune adjusting peptide, wherein the addition quantity of the immune adjusting peptide is 0.5-1wt% of the weight of the tuna activity extract, and the tuna activity extract is prepared through the steps of fishy smell elimination, fat elimination and neutral protease hydrolysis. The compound based on the tuna activity extract disclosed by the invention has the beneficial effects that the antioxidant activity is high, free radicals in human bodies can be removed, fat oxidization can be restrained, cells can be protected from being harmed by the free radicals, and the functions of the human bodies can be protected; raw materials are from tuna scraps, so that resource waste is avoided, the added value of low-value fish products can be increased, the raw materials belong to purely natural extracts, and damage cannot be caused to the health of the human bodies; the signal transduction system of immunocyte can be adjusted, the immunity of the human bodies can be adjusted, and the compound is easy to absorb and digest, good in mouth feel and free from fishy smell; and full-automated operation can be designed, and the production efficiency is high.

A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided.

The invention discloses peptide feed additive used to modulate the immune functions of seawater fish. The peptide feed additive consists of three or more than three types in peptide which is produced by enzymatic hydrolysis of cod fish, skin and internal organs with the molecular weight ranges respectively 100Da to 500Da, 500Da to 1500Da, 1500Da to 3000Da, 3000Da to 5000Da, and 5000Da to 8000Da. 1 percent to 5 percent of immune modulator of the invention is added into feed, which can obviously improve the level of IgM and muramidase in the serum of the seawater fish; the immune modulator of the invention can also improve the liver SOD level of the cultivated fish, thereby improving the oxidation resistant capability of the cultivated fish. The immune modulating peptide feed additive of the invention can also obviously improve the daily weight gain of the fish and reduce the liver index. The peptide feed additive used to modulate the immune functions of the seawater fish is safe without public harm, and the fish cultivated by the additive meet the green food sanitation requirements.

The invention relates to the technical field of anglerfish skin peptides, and provides a preparation method of the anglerfish skin peptides to solve the problems of large molecular weight and bitter and fishy taste of polypeptides prepared from marine fish. Anglerfish skins are degreased by cooperating lipase with isopropanol, high-temperature calcined mussel powder is used to deodorize the degreased anglerfish skins and synergistically remove the bitter taste of the immunoloregulation peptides, an acidic environment, a pulsed electric field and sodium borohydride or sodium borohydride acetatecooperate with each other to weaken the cross-linking degree of the fish skin proteins and enhance the swelling of the fish skin proteins, the fish skin proteins are separated and extracted by a protein extracting enzyme having a weak decomposition effect on the fish skin proteins, and the fish skin proteins are decomposed by a highly-specific protease to prepare the anglerfish skin peptides. Theproportion of the anglerfish skin peptides having a molecular weight of 1000-3500 Da is high; and compared with fish skin proteins, the fish skin peptides have the advantages of high yield reaching about 78 wt%, uniform molecular weight, no bitter or fishy taste, high fish skin utilization rate and high immune activity, and can be applied to immunoloregulation.

The invention relates to an immunomodulating peptide. The immunomodulating peptide comprises an amino acid sequence shown as SEQ ID No.1. The invention further discloses application of the immunomodulating peptide to preparation of drugs or skin care products capable of promoting skin wound healing. The invention provides the novel immunomodulating peptide and the application thereof, and discloses an action mechanism of the immunomodulating peptide for promoting wound healing, and the immunomodulating peptide can be used as a wound healing peptide template.