Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

277 results about "Spirulina sp." patented technology

Essence with anti-wrinkle, repairing and skin-brightening effects as well as preparation method and application thereof

The invention belongs to the technical field of cosmetics, and particularly relates to essence with anti-wrinkle, repairing and skin-brightening effects as well as a preparation method and application of the essence. The essence is prepared from the following components in parts by weight: 10 to 70 parts of herba centellae extract, 0.0015 to 0.04 part of crocus sativus extract, 0.5 to 2.5 parts of spirulina maxima extract, 0.015 to 0.2 part of radix gentianae extract, 0.1 to 1.5 parts of panthenol, 0.25 to 1.5 parts of leuconostoc / radish root fermentation product filtrate, 0.1 to 1.5 parts of carnosine and 0.21 to 5.3 parts of anti-wrinkle components. According to the essence, various effective components such as the centella asiatica extract, the spirulina maxima extract and the radix gentianae extract are matched for use, a unique composite formula is formed, all the components promote one another, the anti-wrinkle, repairing and skin brightening effects of the essence can be remarkably enhanced, and therefore all-around skin care is provided for consumers, and the essence has a good market prospect. The overall quality of the skin can be effectively improved.
Owner:GUANGZHOU HAMMAY COSMETICS CO LTD

Method for efficiently extracting anti-tumor spirulina peptide

The invention relates to the technical field of biology, and discloses a method for efficiently extracting anti-tumor spirulina peptide, which comprises the following steps: pretreating a spirulina raw material; performing enzymolysis treatment; optimizing the extraction process by adopting an intelligent optimization algorithm; multi-mode online monitoring and feedback control are carried out; separating and purifying; peptide fragment structure intelligent prediction and activity screening are carried out; the pretreatment comprises the following steps: selecting a high-quality spirulina raw material, removing impurities, and crushing the treated raw material until the particle size of the raw material reaches a set mesh number. By introducing an improved genetic algorithm, a multi-modal online monitoring and fuzzy-neural network composite control strategy and other intelligent optimization technologies, key parameters, such as enzymolysis conditions, separation and purification parameters, post-processing conditions and the like, in the extraction process can be accurately determined, and limitation and low efficiency of a traditional experience exploration optimization mode are avoided.
Owner:CHONGQING DANGUIYUAN HEALTH TECH CO LTD

Spirulina extracellular vesicle carried astaxanthin hydrogel as well as preparation method and application thereof

The invention discloses a spirulina extracellular vesicle-loaded astaxanthin hydrogel as well as a preparation method and application thereof, and astaxanthin is loaded into spirulina extracellular vesicles to form spirulina extracellular vesicle-loaded astaxanthin nanoparticles. And then, the nano-particles are contained in self-assembled hydrogel composed of aldehyde hyaluronic acid and carboxymethyl chitosan, and the spirulina extracellular vesicle astaxanthin-loaded hydrogel is prepared and obtained. The preparation method comprises the following steps: firstly, preparing the spirulina extracellular vesicle astaxanthin-loaded hydrogel, and preparing the spirulina extracellular vesicle astaxanthin-loaded hydrogel. The hydrogel prepared by the invention can realize synergistic and complementary effects of spirulina extracellular vesicles and astaxanthin, realizes a protective effect on radiodermatitis by relieving oxidative stress, recovering mitochondrial functions and reducing inflammatory response, and shows long-term biological safety.
Owner:ZHEJIANG UNIV +1

Composition containing D-chiro-inositol as well as preparation method and application thereof

The invention discloses a composition containing D-chiro-inositol as well as a preparation method and application of the composition. The composition comprises D-chiro-inositol, Myo-inositol and microcapsule powder, wherein the wall material of the microcapsule powder consists of anhydride modified edible protein and a polysaccharide compound; the edible protein is selected from at least one of spirulina protein, quinoa protein, whey protein and soybean protein; the polysaccharide compound comprises at least one of fucoidin and larch arabinogalactan. Active components are also embedded in the microcapsule powder, and comprise at least one of Omega-3, coenzyme Q10, astaxanthin and vitamin. According to the composition, the stability and bioavailability of fat-soluble active ingredients are improved through microencapsulation, and the composition has a synergistic effect with components such as D-chiro-inositol and Myoinositol, so that insulin resistance is effectively improved, female hormone balance is adjusted, and polycystic ovarian syndrome is improved. The process is simple, is suitable for large-scale production, and can be widely applied to dietary supplements or functional foods.
Owner:HANG ZHOU HE TAN CHUANG WU KE JI YOU XIAN GONG SI +2

Spirulina polypeptide fermentation tank

The utility model relates to the technical field of spirulina polypeptide processing equipment, and discloses a spirulina polypeptide fermentation tank which comprises a tank body, a stirrer is rotatably connected in the tank body, a heat removal assembly comprises heat removal chambers symmetrically and fixedly connected to the top of the tank body, piston plates are movably connected in the heat removal chambers, and the piston plates are movably connected with the stirrer. A cam is arranged above the center of the top of the tank body and is coaxially and fixedly connected with the stirrer, push plates are arranged on the two sides of the cam, a connecting rod is sleeved with a spring, an air inlet pipe is fixedly communicated between the heat removal chamber and the tank body, and an exhaust pipe is further fixedly communicated between the heat removal chamber and the tank body. According to the spiral seaweed polypeptide fermentation tank, the problem that the fermentation effect of spiral seaweed polypeptide is influenced by the temperature rise in the tank body due to the fact that heat generated during fermentation is difficult to discharge is effectively avoided.
Owner:QINGDAO HAOAO ENVIRONMENTAL PROTECTION TECH CO LTD

High-stability functional beverage based on citric acid and maltodextrin dynamic cross-linked microencapsulated spirulina and preparation method of high-stability functional beverage

The invention discloses a high-stability functional beverage based on citric acid and maltodextrin dynamic cross-linked microencapsulated spirulina and a preparation method of the high-stability functional beverage, and belongs to the technical field of functional food processing. Aiming at the problems of flavor defect, easy degradation of active ingredients, poor storage stability, narrow system adaptability and the like of the existing spirulina beverage, the invention initiates a citric acid and maltodextrin dynamic crosslinking wall material system, constructs a core-shell structure microcapsule, and combines a synergistic process of spray drying, gradient homogenization, staged sterilization and the like to prepare the spirulina beverage. The efficient embedding and function maintenance of the spirulina in various beverage substrates are realized. A dense ester bond network is formed on the basis of dynamic esterification reaction of maltodextrin hydroxyl and citric acid carboxyl, a cross-linking degree detection method is optimized, and nonlinear improvement of a synergistic technical effect is realized. The process is stable and controllable, the microcapsule embedding rate is high, the method is suitable for multiple systems such as yoghourt, fruit juice and vegetable protein beverages, and the method can be widely applied to the field of functional foods and has remarkable industrialization value.
Owner:JIANGSU UNIV OF SCI & TECH

Method for extracting phycocyanin from spirulina

The invention discloses a method for extracting phycocyanin from spirulina, and belongs to the field of phycocyanin preparation. The method comprises the following steps: taking spirulina, adding water to obtain a spirulina suspension, performing freeze thawing, intermittent ultrasonic treatment and centrifugation, and collecting supernate to obtain a crude extract of phycocyanin; adding a (NH4) 2SO4 solution into the protein crude extract, standing, and centrifuging to obtain a salting-out precipitate; adding the salting-out precipitate into a mixture of ethylene glycol and inorganic salt, magnetically stirring and layering to obtain a protein solution; and carrying out ultrafiltration, centrifugation and freeze drying on the protein solution to obtain the spirulina phycocyanin. The purity of the phycocyanin can reach 1.0, the extraction rate can reach 69.87%, and the purity and the extraction rate of the phycocyanin extracted through the method are both improved. The extraction method provided by the invention has the advantages of simple process flow, low cost, high efficiency and strong practicability, and is suitable for large-scale industrial production of high-purity phycocyanin.
Owner:INNER MONGOLIA MEDICAL UNIV

Culture base material for lepista sordida rich in strontium, zinc and germanium as well as preparation method and application of culture base material

The invention discloses a culture base material for lepista sordida rich in strontium, zinc and germanium as well as a preparation method and application of the culture base material, and relates to the technical field of edible mushrooms. The culture base stock is prepared from the following raw materials: a nitrogen source, a carbon source, inorganic salt, spirulina, polyglutamic acid and compound bacteria, the compound bacteria comprise aspergillus niger, lactobacillus cavings-like and candida utilis; the culture base stock comprises trace elements; the trace elements comprise at least one of strontium, zinc and germanium. The culture base stock can effectively shorten the growth cycle of lepista sordida, improve the yield and the biotransformation rate, reduce the cost and promote enrichment of trace elements such as strontium, zinc and germanium in lepista sordida.
Owner:HUNAN RES INST OF EDIBLE FUNGI

Spirulina protein-zein composite nanoparticles as well as preparation method and application thereof

The invention discloses spirulina protein-zein composite nanoparticles and a preparation method and application thereof.The preparation method comprises the steps that a zein solution is added into a spirulina protein solution, ethanol in the solution is removed through evaporation, insoluble substances are removed through centrifugation, and spirulina protein-zein composite nanoparticle dispersion liquid is obtained; and freeze-drying to obtain spirulina protein-zein composite nanoparticle powder. The preparation method of the spirulina protein-zein composite nano-particles is simple, low in cost, green and safe, and the obtained nano-particles can be kept stable in a neutral pH environment, have good biocompatibility, can be applied to efficient embedding of bioactive components, and have good application prospects. The light, heat and storage stability of the bioactive components are remarkably improved; and the oxidation resistance, tyrosinase inhibition and in-vitro release performance of the bioactive components are improved.
Owner:JIANGNAN UNIV

Feed additive for producing high-nutrition low-cholesterol poultry eggs

The invention relates to a feed additive for producing high-nutrition low-cholesterol eggs. The feed additive comprises natural grains, microalgae and a microalgae extract, and is prepared from the following raw materials in percentage by weight: 20-70% of corn, 5-10% of wheat bran, 5-10% of soybean meal, 5-20% of spirulina powder, 5-20% of chlorella powder and 5-20% of haematococcus pluvialis. The feed additive is added into laying fowl feed according to the proportion of 1-2wt%, the feed additive and the laying fowl feed are uniformly mixed and then fed, low-cholesterol poultry eggs rich in protein, algae source carotenoid, calcium, magnesium, zinc, iron and other nutritional ingredients can be stably obtained after the laying fowl feed is fed for 2 weeks, compared with common poultry eggs, the cholesterol content can be reduced by 26%, and the poultry eggs are fine and smooth in taste, free of fishy smell and good in taste. The nutrition and quality of poultry eggs are remarkably improved, and economic benefits are improved.
Owner:QINGDAO INST OF TECH PHYSICS OF SCI & TECH OF CHINA

Method for extracting selenium protein and ergothioneine from spirulina

The application relates to a method for extracting ergothioneine and selenoprotein from spirulina, wherein after culturing FACHB-Se1500 strains under the above-mentioned nitrogen deficiency induction condition, a product is obtained, and after purification, selenoprotein containing ergothioneine is obtained; the FACHB-Se1500 strains are cultured in a Zarrouk+Se culture medium for 10 days, and the strain culture conditions are as follows: 25-30 DEG C, pH=9.5, and light intensity is 40 muE.m-2.s-1 ‑2 ·S ‑1 After reaching the plateau, the strains are respectively transferred to a Zarrouk-N, a Zarrouk-Fe and a Zarrouk-Mg culture medium for induction culture for 2 days, and after collecting the algal powder, selenoprotein containing ergothioneine is obtained after purification. The application further screens a spirulina mutant strain with high selenium tolerance, wherein the algal strain tolerating 800 mg / L Na2SeO3 has the best salt tolerance and can tolerate 1000 mM NaCl; and it is found again through the nitrogen deficiency induction that the ergothioneine content can reach 103.65 mu g / g.
Owner:ENSHI ALGAL SELENIUM BIOTECHNOLOGY CO LTD +1

A method for treating wastewater from industrialized aquaculture

This invention belongs to the field of wastewater treatment technology, specifically relating to a method for treating wastewater from industrialized aquaculture. This invention combines physical, biological, and chemical treatment methods, enabling efficient wastewater treatment in a short time, reducing the footprint and operating costs of treatment equipment, and exhibiting high economic efficiency and practicality. The combined use of Spirulina with Bacillus licheniformis, Bacillus subtilis, and Micrococcus luteus forms a stable algae-bacteria symbiotic system in the aquatic environment, accelerating the removal of nitrogen and phosphorus from the aquaculture wastewater and effectively reducing the chemical oxygen demand (COD). After treatment using this method, the wastewater reuse rate is no less than 80%, and the treated wastewater quality meets national discharge standards.
Owner:YUANLING YUXIANG ECOLOGICAL AGRI DEV CO LTD

Composition with light damage resistance as well as application and cosmetics thereof

The invention belongs to the field of daily chemicals, and discloses a composition with light damage resistance, which comprises a ribonucleic acid solution, tetrahydromethylpyrimidine carboxylic acid and a spirulina maxima extract solution in a weight ratio of (60-80): (10-30): (1-10). The composition takes a ribonucleic acid solution, tetrahydromethylpyrimidinecarboxylic acid and a spirulina maxima extract solution as core components, can play a better anti-light damage effect, and samples are sent to a third-party detection mechanism for zebrafish embryo light damage cell apoptosis test. The test result shows that the effect of the composition is better than the cell apoptosis effect of ergothioneine with the same concentration, and evaluation of the skin moisture content increasing effect shows that the composition can well repair and supplement the skin barrier; meanwhile, the invention further discloses application of the composition and cosmetics.
Owner:SHANGHAI YOUREN BIOTECHNOLOGY CO LTD

Sun protectant for crop plants

The present invention relates to the compositions comprising algae, specifically Spirulina platensis and Chlorella, and their use for the treatment of crops, such as fruits. vegetables and arable crops against heat stress, especially sunburn.
Owner:GLOBACHEM NV

Skin repairing composition for relieving red, itching and dry symptoms of sensitive skin and application

The invention provides a skin repairing composition for relieving red, itching and dry symptoms of sensitive skin and application, and belongs to the technical field of cosmetics. The composition comprises an effective amount of an extract of at least two algae selected from the group consisting of Phaeodactylum tricornutum, Spirulina, Chlorella and Micrococcus, and optionally comprises other skin repair ingredients cooperating therewith. The skin repair composition for relieving red, itching and dry symptoms of sensitive skin simultaneously and synergistically intervenes four major causes of sensitive skin formation, namely barrier damage, hyperneurosis, immune inflammation and micro-ecological imbalance, breaks vicious circle and establishes a repair closed loop by utilizing the multiple effects of specific algae active ingredients, and has the effects of relieving the symptoms of red, itching and dry symptoms of sensitive skin and relieving the symptoms of red, itching and dry symptoms of sensitive skin. Therefore, the problems of red skin, itching skin, dry skin and the like are radically relieved.
Owner:青岛中科蓝智生物科技发展有限公司

Method for preparing tropical fish feed by using brine shrimp, and tropical fish feed prepared thereby

The present invention relates to a method for preparing a tropical fish feed by using brine shrimp, and a tropical fish feed prepared thereby, and, more specifically, to: a method for preparing a tropical fish feed by using brine shrimp, and a tropical fish feed prepared thereby, the method feeding spirulina and Haematococcus to hatched brine shrimp to prepare a tropical fish feed, and thus can promote the growth of tropical fish, boost the immune system and improve the consumption, digestion, absorption and palatability for tropical fish.
Owner:SIM HONG SUN

Method for making goldfish feed from fermented abalone viscera powder

The application discloses a method for preparing goldfish feed from fermented abalone viscera powder, and comprises the following steps: preparing fermented abalone viscera powder, including raw material pretreatment, strain activation, anaerobic fermentation and final treatment; preparing a formula of the goldfish feed, including fermented abalone viscera powder, spirulina powder, fish meal, soybean meal, rice bran, wheat flour, fish oil, alpha-starch, soybean lecithin, calcium dihydrogen phosphate, vitamin premix, mineral premix, betaine, garlicin, VC-phosphate, lysine and choline chloride; and preparing the goldfish feed, including accurate batching, uniform mixing, moisture adjustment and molding, grading granulation, drying and cooling and grading screening. The fermentation and feed preparation process is simplified, the complicated enzymolysis-fermentation combined process is abandoned, no professional technical personnel are needed, and the household breeders can prepare the feed through simple equipment, and the enterprises can mass-produce the feed; the formula is optimized for goldfishes in different growth stages, is suitable for multiple goldfishes such as golden goldfish and grass goldfish, and has high application flexibility.
Owner:INST OF AGRI ENG TECH FUJIAN ACAD OF AGRI SCI

A method for directional breeding of active bait for enhancing the stress resistance of east star open seedlings

PendingCN122319970ABiotechnologyArginine
This invention relates to a method for the targeted cultivation of live feed to enhance the stress resistance of grouper fry, specifically a method for the targeted cultivation of grouper fry and its live feed. The live feed includes artichoke culture and rotifer culture. The targeted cultivation of the artichoke culture includes the following steps: placing artichokes in seawater, adding *Cryptospira spp.* powder, *Spirulina* powder, arginine, and *Cinnamomum camphora* oil for cultivation to obtain the artichoke culture; the targeted cultivation of the rotifer culture includes the following steps: placing rotifers in seawater, adding *Nyctaginus* pink bacteria. Natrialba pink Rotifer cultures were obtained by cultivating bacterial powder, spirulina powder, methionine, and sunflower oil. This method, through targeted cultivation of live feed, enriches the live feed with corresponding functional components. After feeding it to newly hatched juvenile scorpion, it can significantly improve the stress resistance of the juveniles and increase their survival rate, thus solving the industry pain points of slow development, low survival rate, and poor stress resistance of newly hatched scorpion scorpion.
Owner:HAINAN CHENHAI AQUATIC CO LTD

Spirulina cultivation methods

This invention discloses a method for cultivating Spirulina, relating to the field of microalgae biotechnology, aiming to overcome the shortcomings of existing technologies in terms of low Spirulina biomass yield and protein content. The method includes: in a first cultivation stage, inoculating Spirulina into a basal culture medium and conducting photoautotrophic cultivation at a light intensity of 5000-10000 lux until the optical density (OD560) reaches 0.6-0.8; in a second cultivation stage, reducing the light intensity to 1000-3000 lux and adding calcium alginate-encapsulated sodium bicarbonate microspheres, cultivating until the algal cell dry weight reaches 1.5-2.0 g / L; in a third cultivation stage, increasing the light intensity to 8000-12000 lux and adding sodium nitrate slow-release granules supported on anion exchange resin. This invention can achieve a synergistic increase in Spirulina biomass dry weight and protein content.
Owner:INNER MONGOLIA AGRICULTURAL UNIVERSITY

A Spirulina probiotic fermentation composition for preventing and treating metabolic associated fatty liver disease, preparation method and application

The present invention belongs to the technical field of microbial fermentation, and particularly relates to a Spirulina probiotic fermentation composition for preventing and treating metabolic associated fatty liver disease, a preparation method and an application. The present invention uses a combination of Lactobacillus acidophilus and Kluyveromyces marxianus to ferment Spirulina to obtain a fermentation composition for preventing and treating metabolic associated fatty liver disease; the Lactobacillus acidophilus was deposited at the China Center for Type Culture Collection on August 29, 2016, with the deposit address: Wuhan University, Wuhan, China, and the taxonomic name: Lactobacillus acidophilus KDB-03 ( Lactobacillus acidophilus KDB-03), deposit number: CCTCC NO: M 2016429. This fermentation composition can significantly increase the total flavonoid and total phenolic contents of Spirulina, enhance its antioxidant activity; significantly enhance the amino acid level in the liver of mice induced by a high-fat diet, significantly improve the metabolic profile of liver tissue, and relieve metabolic associated fatty liver disease induced by a high-fat diet; and can also effectively remove the fishy smell of Spirulina itself.
Owner:SHANDONG ACADEMY OF AGRICULTURAL SCIENCES +2

Urban domestic sewage treatment method

The invention belongs to the technical field of sewage treatment, and particularly relates to an urban domestic sewage treatment method. Chitosan, modified activated carbon and a complex microbial inoculant formed by compounding any two strains of spirulina, rhodotorula mucilaginosa and micrococcus luteus are specifically combined, the chitosan in the composition serves as a carrier of the complex microbial inoculant, nutrients can be provided for survival of the complex microbial inoculant, and the survival time of the microbial inoculant is prolonged; the modified activated carbon has high adsorption capacity on the complex microbial inoculant, so that slow release of the complex microbial inoculant in the later period is facilitated; therefore, the composition provided by the invention can be used for purifying the urban domestic sewage, the purpose of purifying the urban domestic sewage is achieved, ecologicalization and recycling of domestic sewage treatment are realized, and a new thought is provided for urban sewage treatment.
Owner:HAIKOU KAIYUAN WATER CO LTD

Aged muscle repairing composition and application

PendingCN121926862ACosmetic preparationsToilet preparationsBiotechnologyLaminaria japonica
The invention provides a senescent muscle repairing composition and application, and belongs to the technical field of cosmetics. Comprising polyunsaturated fatty acid, carotenoid, peptides, polydeoxyribonucleotide PDRN and at least one algae extract selected from chlorella, spirulina, brown algae and red algae. According to the senescent muscle repairing composition prepared by the invention, through a carefully selected natural active component system, the composition has a synergistic effect from two major directions of promoting synthesis of ECM key components and inhibiting excessive degradation of ECM, and improves the structural quality of ECM, so that the steady state of skin ECM is effectively recovered, and the purposes of improving wrinkles and improving compactness and elasticity are achieved.
Owner:青岛中科蓝智生物科技发展有限公司

Microalgae-microorganism compound preparation for improving saline-alkali soil and application

The invention belongs to the technical field of soil remediation, and relates to a microalgae-microorganism compound preparation for improving saline-alkali soil and application. The microalgae-microorganism compound preparation is prepared from spirulina, chlorella, nostoc, scenedesmus obliquus, bacillus mucilaginosus, bacillus mucilaginosus and pseudomonas. The microalgae-microorganism compound preparation for improving the saline-alkali soil can improve the available phosphorus content of the soil, increase the available potassium content of the soil and effectively improve the soil; soil bulk density is reduced, and soil hardening is improved; therefore, the fertilizer retention property of the soil is enhanced, the growth and development of crop roots are facilitated, the crop yield is remarkably improved, and the application prospect is wide.
Owner:SHANDONG ZHENGYUAN YEDA TECH CO LTD

Chitosan-based nano-preservation agent for spirulina preservation and preparation method thereof

This invention belongs to the field of algae preservation technology, specifically relating to a chitosan-based nano-preservative for spirulina preservation and its preparation method. The preparation method of the chitosan-based nano-preservative includes the following steps: (1) adding eugenol and zinc acetate sequentially to a tannic acid solution, mixing well, and then ultrasonically treating at 35-45℃ for 2-6 hours to obtain a nanosphere system; (2) adding the nanosphere system obtained in step (1) to a chitosan solution, then adding zinc acetate to the chitosan solution, and stirring and reacting at 25-60℃ for 8-12 hours to obtain the chitosan-based nano-preservative. This invention achieves a multi-effect combination of "antibacterial-antioxidant-slow release" through the synergistic effect of the antibacterial action of eugenol, the antioxidant / anti-inflammatory action of tannic acid, and the auxiliary antibacterial and cross-linking action of zinc acetate, thus solving the problem of the functional limitations of single preservation technology.
Owner:ZHENGZHOU UNIV

Spirulina harvesting and filtering device

The utility model relates to the technical field of filtering devices, and discloses a spirulina harvesting and filtering device which comprises a box body, supporting legs are fixedly connected to the two sides of the bottom of the box body, connecting blocks are rotationally connected to the two sides of the inner wall of the box body, the same fixing ring is fixedly connected between the two connecting blocks, and the fixing ring is obliquely arranged. A rotating ring is rotationally connected to the inner side of the fixing ring, the same rotating supporting plate is fixedly connected between the two sides of the inner wall of the rotating ring through a connecting rod, a screen is fixedly embedded in the middle of the rotating supporting plate, a square hole matched with the screen is formed in the middle of the rotating supporting plate, and a U-shaped fence is fixedly connected to the top of the rotating supporting plate; a connecting rod is fixedly connected to the end, away from the fixing ring, of the rotary supporting plate. The screen cleaning device has the technical effects that the screen can be thoroughly cleaned in a short time, the screen cleaning process is greatly simplified, the shutdown maintenance time of equipment is shortened, the continuity and the stability of the whole harvesting operation are improved, and the labor cost and the equipment maintenance cost are reduced.
Owner:ETUOKEQI KANGSHENG SPIRULINA CO LTD

Oral multi-drug delivery hydrogel as well as preparation method and application thereof

The invention discloses oral multi-drug delivery hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the delivery hydrogel, spirulina platensis and traditional Chinese medicine ingredient astragalus polysaccharide are used as raw materials and are added into network-shaped hydrogel formed by combining carboxymethyl chitosan / sodium alginate. The method is easy to implement, safe in component and high in encapsulation efficiency. The composite hydrogel is stated to have the following effects: after oral administration, the medicine can be protected to completely pass through the stomach, the intestinal retention is prolonged, and the medicine can be continuously released at the focus part; the immune checkpoint inhibitor related intestinal inflammation is relieved, and the anti-tumor effect of the immune checkpoint inhibitor is assisted; and noninvasive monitoring of the medicine in the body is realized. According to the invention, a bioactive material is used as a potential treatment strategy for enhancing anti-tumor reaction and relieving immune checkpoint inhibitor-related adverse reaction, and can be more widely applied to treatment of pathological changes related to intestinal microbiome imbalance.
Owner:ZHEJIANG UNIV

Preparation process of mulberry, melon, fruit and vegetable protein paste capable of repairing islet cells and promoting insulin secretion

The invention provides a preparation process of mulberry, melon, fruit and vegetable protein paste for repairing islet cells and promoting insulin secretion, and relates to the technical field of hypoglycemic products. The prescription comprises a mulberry leaf extract, a bitter gourd extract, a white gourd extract, a cyclocarya paliurus extract, a sweet ampelopsis grossedentata extract, cucumbers, pumpkins, onions, corn stigma, lettuces, brassica juncea, asparagus, Chinese yams, radix puerariae, purple cabbages, broccoli, carrots, hericium erinaceus, black beans, white beans, zebra beans, hyacinth beans, cordyceps flowers, mushrooms, needle mushrooms, undaria pinnatifida, spirulina, leek seeds, lotus seeds, almonds, quinoa and spina date seeds. , chia seeds, pumpkin seeds, silkworm chrysalis and tenebrio molitor. The traditional Chinese medicine composition is prepared according to the traditional Chinese medicine theory and a scientific formula, and clinical verification shows that the traditional Chinese medicine composition has the effects of reducing blood sugar and blood fat, promoting digestion, invigorating the stomach, nourishing the liver and tonifying the kidney, can effectively improve and prevent diabetes mellitus, can also regulate gastrointestinal peristalsis and is helpful for regulating constipation. The prescription is simple to operate, low in cost and suitable for mass production.
Owner:NANCHANG SHENQITANG HEALTH MANAGEMENT CO LTD

Application of spirulina in preparation of products for treating diabetes-related diseases

The invention discloses an application of spirulina (SP) in preparation of a product for treating diabetes-related diseases. According to the application disclosed by the invention, spirulina is found to be capable of alleviating oxidative stress in cells, promoting macrophages to be converted from a proinflammatory M1 type to an anti-inflammatory M2 type, remodeling redox balance and inhibiting an inflammatory microenvironment. More importantly, it is found that spirulina can lower the level of advanced glycation end products (AGEs) to inhibit the glycosylation process, and healing of diabetic wounds and bone defects is accelerated. In addition, the invention also finds that the spirulina can promote proliferation, migration and vascularization of vascular endothelial cells in a high-glucose and high-fat microenvironment, and further accelerate healing of bone defects. On the basis, the invention provides application of spirulina in preparation of products for treating diabetes-related diseases.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Color-improving high-fat compound feed for fancy carp and preparation method of color-improving high-fat compound feed

The invention discloses color-improving high-fat compound feed for fancy carps and a preparation method of the color-improving high-fat compound feed, and belongs to the technical field of feed. The method is used for solving the technical problem that in the prior art, crude protein and pigment compositions in the color-increasing high-fat compound feed for the fancy carp are easily influenced by factors such as light, heat and pH. The color-improving high-fat compound feed for the fancy carp comprises a crude protein powder mixture, a grease expanding agent, a pigment compound, monocalcium phosphate, an antioxidant, choline, vitamin A and vitamin K. Mixing the spirulina, the astacin, the green algae and the xanthophyll to obtain a mixture; coating the mixture with an organic monomer butyl cyanoacrylate to prepare a pigment compound; the peony seed oil and the olive oil are used as wall materials to coat mixed core material powder composed of the fish meal, the soybean meal, the shrimp meal and the peanut meal, and the grease expanding agent is prepared. The prepared color-enhancing high-fat compound feed for the fancy carp has the effects of enhancing color enhancement, avoiding fat deposition of the fancy carp and balancing and enriching various nutrient elements.
Owner:TAIZHOU FENGDA AGRI & ANIMAL HUSBANDRY TECH CO LTD