295 results about "Protein composition" patented technology

The invention belongs to the technical field of biology, and particularly relates to a sweet protein composition as well as a preparation method and application thereof. The sweet protein composition comprises the following sweet proteins: at least one of Brazilian sweet protein, kiwi sweet protein, omethoate sweet protein, rhizoma curculiginis sweet protein, capparis masaikai sweet protein, miracle fruit element, petatin, thaumatin and agrocybe cylindracea sweet protein. The invention also provides a preparation method of the sweet protein composition, and the preparation method simplifies the purification process and significantly improves the purity and yield of the sweet protein. The sweet protein composition disclosed by the invention is suitable for various foods, beverages, medicines and health-care products, so that the taste of the medicines is improved, and the compliance of patients is improved. In addition, the sweet protein composition can also be used in weight-losing products, antioxidant supplements and health-care products for enhancing immunity, and oral care products such as toothpaste and mouth wash, and can provide pleasant sweetness and improve mouth feel.

Disclosed are methods of treating radiation-induced skin damage comprising administering extracellular vesicle and protein compositions.

The invention discloses an application of MAPK-related protein for regulating plant type and growth and development of plants. The invention belongs to the field of botany, and particularly relates to application of MAPK related protein for regulating plant type, growth and development. The invention provides a method for regulating and controlling plant type and growth development, which comprises regulating and controlling the activity and / or content of protein in a target plant, or / and regulating and controlling the expression quantity of a coding gene of the protein so as to regulate and control the plant type and growth development of the plant. The protein is the following protein: a composition consisting of a protein FvMAPK3 of which the amino acid sequence is SEQ ID No. 3 and a protein FvMAPK6 of which the amino acid sequence is SEQ ID No. 6. Experiments prove that the expression of the two proteins FvMAPK3 and FvMAPK6 is reduced, so that the plant type and growth and development of strawberries can be regulated and controlled, and important theoretical significance is achieved for strawberry breeding.

Methods of treating lumbar facet joint syndrome by administering extracellular vesicle and protein compositions.

A first brine free of salt and phosphate for treating a food product by injection of the brine into the food product. The brine is formed from an emulsion consisting of water, saltless flavoring and protein. The protein is from the same type of food product as the food product being injected with the brine. A second brine especially for ham with the bine being similar to the first brine, but with a low sodium content of a maximum of 0.5% to 1.0% of the weight of the food product. A third brine for pork bellies without phosphate.

The invention belongs to the technical field of food, and particularly relates to a high-satiety liquid protein composition as well as a preparation method and application thereof. The high-satiety liquid protein composition is characterized by being prepared from the following raw materials in parts by weight: 800 to 1000 parts of protein, 110 to 160 parts of vegetable oil, 700 to 800 parts of carbohydrate, 120 to 150 parts of dietary fiber, 5 to 15 parts of vitamin, 1 to 8 parts of mineral substance, 35 to 40 parts of emulsifier, 12 to 15 parts of stabilizer, 17 to 20 parts of pH regulator and 5 to 10 parts of essence. Under the comprehensive action of all the components, the liquid protein composition can keep the milk state stable, fat components are not subjected to lactation separation, protein components are not subjected to sedimentation and layering, the macroscopic state is stable, and nutrients in the product are uniformly distributed.

The present disclosure provides a method of preparing a lyophilized bispecific molecule composition comprising (a) inducing ice nucleation in a liquid protein composition having a bispecific molecule concentration of at least about 10 mg / ml in a vial exposed to a first temperature of about-18 DEG C to about-10 DEG C for about 60 minutes to about 270 minutes; (b) exposing the vial of (a) to a second temperature of about-25 DEG C to-50 DEG C for about 1 hour to about 5 hours; and (c) drying the composition of (b) at a third temperature of about-5 DEG C to about-25 DEG C for about 25 hours to about 70 hours, and (d) further drying the composition of (c) at a fourth temperature of about 25 DEG C to about 50 DEG C for about 4 hours to about 12 hours to obtain a vial comprising a lyophilized bispecific molecular composition, the composition has a percentage content of high molecular weight material (HMWS) of less than or equal to about 1.5% (mA / ). The disclosure further provides lyophilized bispecific molecule compositions prepared via the methods described herein.

Soybean plants producing seeds and soybean seeds comprising increased protein content are provided. Also provided are soybean plants producing seeds and soybean seeds comprising increased amounts of essential amino acids such as methionine, tryptophan or lysine. Protein compositions having increased essential amino acids can be made from the soybean seeds. Additionally, methods for generating and using plants, seeds and protein compositions having increased protein content or increased amounts of essential amino acids are disclosed.

This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

The present invention relates to the pharmaceutical compositions of lectin proteins and its use for the prevention, treatment and cure of inflammation, including inflammatory disease. The invention specifically relates to the pharmaceutical compositions for topical application comprising lectin proteins and its use for prevention, treatment and cure of inflammation due to chemotherapy and / or radiotherapy. The lectin may comprise an amino acid sequence having sequence of SEQ ID NO: 1 or at least 70% homology to SEQ ID NO: 1.

The invention relates to the technical field of microbial fermentation, in particular to a fermented fish protein composition and a preparation process thereof. The preparation process of the fermented fish protein composition comprises the following steps: adding a substrate, compound zymophyte and the like into a fermentation container for fermentation; taking part of the fermentation liquor, heating for denaturation and low-temperature renaturation, adding the mesoporous silica carrier, and introducing into the fermentation container again; and continuously monitoring, and after fermentation is completed, carrying out solid-liquid separation and subsequent treatment on the fermentation liquid to obtain the fermented fish protein composition. The enzyme is immobilized through combination of heating denaturation and low-temperature renaturation, so that certain inhibitory structures in enzyme molecules can be broken, the enzyme is easier to interact with other molecules, the activity of the enzyme molecules is recovered, specific binding between the enzyme and the mesoporous silica carrier is promoted, and the immobilization efficiency is improved; the immobilized enzyme shows higher stability and activity, the service life is prolonged, and the loss of the enzyme is reduced, so that the fermentation efficiency is improved.

Compositions and methods for controlling insect pests are disclosed. In particular, novel insecticidal proteins having toxicity to at least coleopteran insect pests are provided. Nucleic acid molecules encoding the novel insecticidal proteins are also provided. Methods of making the insecticidal proteins and methods of using the insecticidal proteins and nucleic acids encoding the insecticidal proteins of the invention, for example in transgenic plants to confer protection from insect damage, are also disclosed.

The present invention provides a botulinum toxin protein composition, mainly comprising botulinum toxin protein, a saccharide, a salt, and human serum albumin. The botulinum toxin protein composition of the present invention features good activity and stable properties, and can maintain the activity of the botulinum toxin protein at a high level after long-term storage.

The present invention discloses a novel protein composition comprising a first protein or polypeptide selected from a specific group. The protein composition has a broad-spectrum and efficient treatment effect on inflammatory diseases. The invention also discloses a preparation method of the protein composition and application of the protein composition in preparation of medical implants, medical devices or drugs.

Methods are disclosed for making a high protein, pliable food composition that remains pliable over a shelf life of at least 6 months, and food compositions made by disclosed methods. Food products containing disclosed food compositions are also disclosed.

The invention discloses an application of an MAPK related protein for regulating and controlling the flowering phase and fertility of plants. The invention belongs to the field of botany, and particularly relates to application of MAPK related protein for regulating and controlling the flowering phase and fertility of plants. The invention provides a method for regulating and controlling the flowering phase and fertility of a plant, which comprises the step of regulating and controlling the activity and / or content of protein in a target plant, or / and regulating and controlling the expression quantity of a coding gene of the protein, so as to regulate and control the flowering phase and fertility of the plant. The protein is the following protein: a composition consisting of a protein FvMAPK3 of which the amino acid sequence is SEQ ID No. 3 and a protein FvMAPK6 of which the amino acid sequence is SEQ ID No. 6. Experiments prove that the flowering phase and fertility of the strawberries can be regulated and controlled by reducing the expression of the two proteins FvMAPK3 and FvMAPK6, and important theoretical significance is achieved for strawberry breeding.

The present invention relates to a method to increase the physical stability of a β-lactoglobulin and to a β-lactoglobulin with increased physical stability. The present invention further relates to the use of an extraneous β-lactoglobulin to enhance the physical stability of a composition comprising a protein and the extraneous β-lactoglobulin.

The invention belongs to the technical field of food processing, and particularly relates to a compound capable of improving illumination storage stability of phycocyanin and a preparation method of the compound. The compound is prepared from phycocyanin and zein through an anti-solvent precipitation method, the particle size range is 108-345 nm, the main secondary structure of the phycocyanin is reserved, and the specific blue hue and fluorescence characteristics of the phycocyanin can be maintained after continuous illumination storage at 25 DEG C for 28 days. The preparation method is simple, and the protein is composed of two natural proteins and is high in safety. On one hand, the problem that the phycocyanin easily loses the blue hue under illumination storage is solved, and on the other hand, the technical problem that the phycocyanin product can only be stored in a cold storage mode or applied to high-sugar food generally is solved.

The present disclosure relates to a composition comprising a recombinant botulinum toxin protein with improved stability. The composition according to the present disclosure comprises a sugar alcohol as a stabilizer. More specifically, the present disclosure provides a composition comprising a botulinum toxin type A light chain protein or a functional fragment thereof, and comprising, as a stabilizer, a sugar alcohol having six or fewer carbon atoms and / or a solubility in water of 150 mg / mL or more at 20°C. The composition of the present invention can achieve the effect of maintaining the biological activity of the recombinant botulinum toxin light chain protein at a usable level while sufficiently ensuring the stability of the botulinum toxin protein through the stabilizer.

Methods of determining the stoichiometry of a viral capsid and / or determining the heterogeneity of protein components in a viral capsid are described.

The invention discloses an auxiliary protein composition, iron oxide nanoparticles, a preparation method and application, the composition comprises an SC protein with an amino acid sequence as shown in SEQ ID NO: 1 and an ST protein with an amino acid sequence as shown in SEQ ID NO: 2, and the composition can be used for modifying the iron oxide nanoparticles. The auxiliary protein composition can effectively promote endocytosis of the iron oxide nanoparticles, and assists the iron oxide nanoparticles to realize lysosome escape; moreover, the iron oxide nanoparticles modified by the auxiliary protein composition are good in biocompatibility and long in retention and storage time in cells, can be used for long-time labeling of the cells, and have wide clinical transformation and application prospects as a cell tracer agent.

The present invention is in the field of protein compositions, in particular protein compositions for infant milk formula. The protein compositions according to the invention comprise whey protein, casein and high isoelectric point proteins, such as those having an isoelectric point of at least 6.0. The present invention further relates to the uses of the protein compositions.

The present invention discloses a plant gene editing method for insufficiently editing a target gene, and belongs to the field of plant genetic engineering. The present invention provides a method for plant gene editing, which can achieve insufficient editing of the plant genome by using a promoter that functions after the callus enters the differentiation period to drive the expression of a gene editing functional element, thereby being able to be used to create a heterozygous mutant in the plant. The present invention also provides a promoter sequence for incomplete editing of the plant genome, a nucleic acid protein composition, and a method for creating a plant heterozygous mutant.

The present application relates to the technical field of health care products, in particular to a pelvic floor muscle repairing composition containing supermolecular tightening Dropsordry and a preparation method thereof, which comprises the following components in mass fraction: 10-14 parts of protein composition, 20-24 parts of chitosan modified Dropsordry, 5-7 parts of freeze-dried powder of Lactobacillus bulgaricus, 10-12 parts of hyaluronic acid, 6-8 parts of glycine and 15-17 parts of proline; each part of the protein composition comprises 20-30 parts of myosin, 30-34 parts of actin, 5-10 parts of hydrolyzed collagen and 240-280 parts of deionized water. The pelvic floor muscle repairing composition can reduce drug toxicity, reduce the amount of drug administration, continuously supplement the required elements of the body during treatment, and quickly relieve the constipation problem caused by the functional damage of the pelvic floor muscle.

This invention relates to the field of protein composition analysis technology, and particularly to a method for protein composition analysis of succinyl gelatin injection solution, comprising: preparing a mobile phase and several reagents; pretreating several succinyl gelatin injection solution samples to obtain several peptide fragments; setting chromatographic and mass spectrometric conditions; separating the peptide fragments by chromatography and eluting them according to an elution program; acquiring data of the eluted peptide fragments using a mass spectrometer to obtain primary and secondary mass spectra; comparing the acquired mass spectra with a database using software to identify the protein composition in the samples; determining the pass / fail status of the identification process based on a protein component consistency index, and, based on non-compliance conditions, increasing the number of samples according to the difference between the preset consistency index and the protein component consistency index. This invention improves the accuracy of protein composition analysis.

The present invention provides the use of a protein composition comprising Methylotroph bacterial biomass or at least one fraction thereof for supplementing or substituting meat proteins in food or feed products. Also provided are food and feed ingredients, food and feed products and methods of making same.

The application provides a protein composition for predicting the prognosis effect of metastatic hormone-sensitive prostate cancer and application thereof, and belongs to the technical field of prognosis evaluation.The protein composition for predicting the prognosis effect of metastatic hormone-sensitive prostate cancer comprises protein molecules for evaluating drug resistance of a patient and protein molecules for evaluating sensitivity of the patient; the protein molecules for evaluating drug resistance of the patient comprise MCM4, NT5E, LTBP4, IAH1, HP, DOCK2 and EEF1A2; and the protein molecules for evaluating sensitivity of the patient comprise TFF3, FABP5 and LAMP2.The application constructs a molecular typing of mHSPC based on the above protein composition, evaluates the sensitivity of a mHSPC patient to ADT treatment in advance, and thus realizes precise treatment.

To provide methods for producing aflibercept with reduced amount of aflibercept variants.SOLUTION: Disclosed is a method for producing aflibercept with a reduced amount of aflibercept variants expressed in a host cell cultured in a chemically defined medium (CDM), where the target value of aflibercept variants can be obtained when the cumulative concentration of iron in the CDM is about 55.0 μM or less, the cumulative concentration of copper in the CDM is about 0.8 μM or less, the cumulative concentration of nickel in the CDM is about 0.4 μM or less, the cumulative concentration of zinc in the CDM is about 56.0 μM or less, the cumulative concentration of cysteine in the CDM is about 10.0 mM or less, and / or when any single anti-oxidant is added in the CDM the cumulative concentration is about 0.001 mM to about 10 mM, and when a plurality of anti-oxidants are added the cumulative concentration of total antioxidants is about 30 mM or less.SELECTED DRAWING: Figure 1

The invention discloses a TIR-STAND anti-phage, an anti-virus system and application of the TIR-STAND anti-phage and the anti-virus system and relates to the technical field of biology. The protein composition provided by the invention is composed of three structural domains of TIR, NTPase and TPR; nucleic acid molecules, recombinant expression vectors, and host cells expressing the protein compositions are provided; the invention also provides an application of the protein composition in bacteriophage resistance or virus resistance. According to the invention, the knowledge of the existing immune system for resisting bacteriophage is expanded, and a new thought and application are provided for the development of biotechnology, the prevention and treatment of clinical pathogenic bacteria and the anti-bacteriophage pollution in the fermentation process.