19 results about "Diaminopyrimidine" patented technology

The present invention provides a pharmaceutical composition comprising (S)—N-(1-(2-((4-amino-3-nitrophenyl)amino)-6-propylpyrimidin-4-yl)pyrrolidin-3-yl)acetamide, which has activity as a 5-HT4 receptor agonist, or a pharmaceutically acceptable salt thereof, and an acidifying agent, as well as a method for preparing the same.

The present application relates to the field of hair preparations, in particular to a composition with anti-hair loss and oil control functions and a preparation method thereof.The raw materials of the composition include diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide, lactobacillus / soybean milk fermentation product filtrate combined with PPG-13-decyltetradecinol polyether-24, PPG-70 polyglyceryl-10 ether, African neem bark extract, Anemarrhena asphodeloides root extract, Panax ginseng root extract, Zingiber officinale root extract, Polygonum multiflorum root extract, humectant, emollient and water.The composition has excellent anti-hair loss and oil control effects, high stability and can still exist stably in a high temperature environment.

The invention provides a diaminopyrimidine compound as shown in a formula I. The compound can be used as a three-mutant type (sensitive mutation / T790M / C797S) EGFR (epidermal growth factor receptor) kinase inhibitor and is used for preventing and / or treating tumors.

The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.

The invention relates to the technical field of hair loss preventing and hair growing compositions, and discloses a hair loss preventing and hair growing composition and a preparation method and application thereof.The hair loss preventing and hair growing composition comprises a core active ingredient which is diaminopyrimidine oxide; the plant extract is selected from at least one of a ginseng root extract, a cacumen biotae extract, a polygonum multiflorum extract, a rosemary extract, a cordyceps sinensis extract and a tuber melanosporum extract; a porous support material. According to the composition, the core active component and the specific plant extract are jointly loaded in the porous carrier material, so that the skin retention volume and permeation efficiency of the active component after local application to scalp are remarkably improved, and more lasting and more efficient targeted delivery is realized, so that the anti-hair loss and hair growth effects are enhanced, and the anti-hair loss and hair growth effects are improved. The problems that active ingredients in a traditional preparation are easy to lose and the transdermal absorption is poor are solved.

The invention discloses a 2, 4-diaminopyrimidine-6-heteroaromatic pyrimidine compound and application thereof, and the 2, 4-diaminopyrimidine-6-heteroaromatic pyrimidine compound has the following structural general formula as shown in the specification, wherein W, X, Y and Z are independently selected from hydrogen or nitrogen. The 2, 4-diaminopyrimidine-6-aromatic heterocyclic pyrimidine compound designed and synthesized by the invention is a novel NF-kappa B induced kinase (NIK) inhibitor, and is suitable for drug development taking NIK as a target spot, and the obtained drug can be used for treating malignant tumors such as leukemia, multiple myeloma glioma and the like.

The present invention relates to a solid form of 5-((2-ethynyl-5-isopropylpyridin-4-yl)oxy)pyrimidine-2,4-diamine or a hydrate thereof, a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and a use of the solid form for the prevention or treatment of a disease modulated by P2X3 and / or P2X2 / 3 receptor antagonists.

The invention discloses a high-strength wear-resistant fastener and a preparation process thereof, and relates to the technical field of fastener preparation. According to the preparation method, dipentaerythritol and 1, 1, 1-trifluoro-2, 3-epoxypropane are taken as raw materials to prepare polyfunctional fluorine-containing polyol, then double-bond-containing polyfunctional polyurethane acrylate and a macromolecular photoinitiator are respectively prepared through the polyfunctional fluorine-containing polyol, and molybdenum disulfide is modified through 2, 4-dimercapto-5, 6-diaminopyrimidine, so that the photoinitiator is prepared. The preparation method comprises the following steps: preparing functional molybdenum disulfide, blending double-bond-containing polyfunctional polyurethane acrylate, the functional molybdenum disulfide and a macromolecular photoinitiator to obtain composite polyfunctional polyurethane acrylate, mixing the composite polyfunctional polyurethane acrylate with an auxiliary agent to obtain a wear-resistant coating, coating the surface of a copper-plated fastener with the wear-resistant coating, and performing ultraviolet curing to obtain the wear-resistant copper-plated fastener. And the formed wear-resistant coating has the properties of high wear resistance, high impact strength and the like.

The invention discloses a composition and application of the composition in products for reducing alopecia. The composition disclosed by the invention is prepared from one or more of a cacumen biotae extract, diaminopyrimidine oxide and p-hydroxyacetophenone. The composition disclosed by the invention has a quick effect and a lasting and effective anti-hair-loss effect.

The present application provides a kind of diaminopyrimidine compound shown in formula I, and the compound can be used as three mutant (sensitive mutation / T790M / C797S) EGFR kinase inhibitor for preventing and / or treating tumor.

A method for treating, resisting and alleviating endometriosis-associated pain, relating to the field of biological medicine, comprising administering, to an individual in need thereof, a therapeutically effective amount of a diaminopyrimidine compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.

The application discloses a kind of pyrimidine-based covalent organic polymer materials and its preparation method and its application in photocatalytic production of hydrogen peroxide.The material is prepared by solvothermal method: 2,4-diaminopyrimidine is dispersed with benzene-1,3,5-tricarboxaldehyde in solvent, acetic acid aqueous solution is added and ultrasonic mixed uniformly;System is degassed after three "freeze-vacuum-thaw" cycle at liquid nitrogen temperature, melt seal glass tube, constant temperature reaction for a period of time.The preparation process provided by the application is simple, the obtained material has excellent interface charge transport capacity and high efficient photo-generated carrier separation efficiency, can produce hydrogen peroxide under light condition, the yield reaches 4167.5 μmol / g per hour, has good application prospect.

The application relates to the technical field of chemical medicines, in particular to a kind of dianilopyrimidine macrocycle containing crown ether fragment and its preparation method and application.A series of dianilopyrimidine macrocycle containing crown ether fragment is synthesized in the application, and the problem of poor clinical effect of drug in current brain glioma treatment is overcome.The series of compounds have good inhibitory activity on brain glioma, and are suitable for treating brain glioma and related drug research and development.Moreover, the drug is widely distributed in vivo and is rapidly cleared, so that the possibility of drug accumulation poisoning is avoided;oral bioavailability is moderate (F=18.7%);these findings highlight the advantages and challenges of the pharmacokinetic characteristics of compound 13, and lay a foundation for further optimizing and improving the in-vivo stability and bioavailability strategy.

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine 3-N-oxide and / or an organic or mineral acid salt thereof and / or a hydrate thereof, piroctone olamine, niacinamide, and at least 1% by weight of particular hydroxylated compound.The invention also relates to a process for the cosmetic treatment of human keratin materials such as the skin, notably human scalp, hair and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention.The present invention also relates to the use of said cosmetic composition for treating the loss and / or promoting the regrowth of keratin fibres.

The present application relates to the technical field of chemical medicine, in particular to a kind of diamino pyrimidine compound containing phenyl nitrogen mustard fragment and its preparation method and application.A kind of diamino pyrimidine compound containing phenyl nitrogen mustard fragment is provided in the present application, its structural formula is as shown in formula (I).The compound is a new compound newly synthesized.The diamino pyrimidine compound containing phenyl nitrogen mustard fragment is novel in structure, has strong inhibitory effect on tumor cells, and has good application prospect in the preparation of antitumor drugs.

The invention provides a diaminopyrimidine oxide nano-micelle as well as a preparation method and application thereof in anti-hair loss cosmetics, and relates to the technical field of cosmetics, the diaminopyrimidine oxide nano-micelle comprises the following components in percentage by mass: 1-1.5% of an ampholytic surfactant, 0.1-0.5% of glycyrrhizic acid and the balance of a solvent, the ampholytic surfactant and the glycyrrhizic acid are selected to be matched to form the nano-micelle, and the nano-micelle is added into the anti-hair loss cosmetics. When the structural stability of micelles is met, the drug loading concentration of glycyrrhizic acid is optimized, the synergistic effect of glycyrrhizic acid and glycyrrhizic acid is balanced, glycyrrhizic acid is controlled to be not more than 0.5%, the requirement that the total concentration of glycyrrhizic acid in cosmetics is not more than 0.5% is met, hair growth can be promoted, hair follicle targeting is achieved, the glycyrrhizic acid can be accumulated at hair follicle parts, diaminopyrimidine oxide can be wrapped, and the application prospect is wide. The water solubility and the transdermal performance of the diaminopyrimidine oxide are improved.

The present application belongs to the field of biotechnology. More particularly, it relates to a hair loss prevention serum and a preparation method thereof. The hair loss prevention serum comprises the following components in mass fraction: a hair loss prevention composition 1-3%, a humectant 2-5%, a solubilizer 1-5%, a thickening agent 0.1-1%, a hair conditioner 1-3%, a soothing agent 1-3%, a pH regulator 0.1-1%, and a solvent in the remaining amount; and the hair loss prevention composition is composed of psoralen and 6-pyrrolidinyl-2,4-diaminopyrimidine-3-oxide in a weight ratio of 1:0.1-1. The hair loss prevention serum is specially designed for patients with androgenetic alopecia, and is mainly effective in preventing hair loss and improving hair quality. The core components are psoralen and dianinopyrimidine oxide, supplemented by South American amaranth root extract, glycerol, and cocoyl glutamic acid, and the serum has the characteristics of strong hair loss prevention and no irritation.