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135 results about "Diaminopyrimidine" patented technology
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Diaminopyrimidines are a class of organic chemical compounds that include two amine groups on a pyrimidine ring. They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim and the antibiotics Iclaprim and trimethoprim).
Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist and methods of making the compounds.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidines as P2X3 and P2X2/3 modulators
ActiveUS20070049534A1Antibacterial agentsOrganic active ingredientsDiaminopyrimidineReceptor antagonist
Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the compounds being of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidines as P2X3 and P2X2/3 antagonists
ActiveUS20050209260A1Antibacterial agentsOrganic active ingredientsDiaminopyrimidineReceptor antagonist
Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Method of inhibiting neoplastic cells with 4,5-diaminopyrimidine derivatives
InactiveUS6380206B1Eliminating and inhibiting growthModulating apoptosisOrganic active ingredientsBiocideDiaminopyrimidineOncology
A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to 4,5-diaminopyrimidine derivatives.
Owner:OSI PHARMA INC
Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists
The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.
Owner:KOSOGOF CHRISTI +9
Diaminopyrimidines as P2X3 and P2X2/3 antagonists
Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt, solvate or prodrug thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases
ActiveUS20150057299A1Suppressing central modulationReduced activityBiocideNervous disorderDiseaseDiaminopyrimidine
Owner:AFFERENT PHARMA
Selective synthesis of CF3-substituted pyrimidines
The present invention relates to a method of making a compound of the formulawherein X1, X2 and R3—R4 are as defined herein. The method includes reacting a compound of the formulawith an amine of formula 3 (HNR3R4) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.
Owner:PFIZER INC
Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines
A process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines of formula I, wherein R1 denotes a hydrogen atom or a C1-C6 alkyl group, R2 denotes an optionally substituted C6-C10 aryl group, R3 denotes a hydrogen atom or a C1-C6 alkyl group, and R4 denotes a hydrogen atom or an optionally substituted C1-C6 alkyl, C3-C6 alkenyl, C3-C8cycloalkyl or a 4- to 7-membered, nitrogen-containing heterocyclyl group, or R3 and R4 together with the nitrogen atom linked to them denote an optionally substituted heterocyclyl group.
![Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines](https://images-eureka.patsnap.com/patent_img/f6c87757-1e67-4d64-92b1-92c0f71d3ba7/US20020198380A1-20021226-C00001.png "Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines")
![Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines](https://images-eureka.patsnap.com/patent_img/f6c87757-1e67-4d64-92b1-92c0f71d3ba7/US20020198380A1-20021226-C00002.png "Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines")
![Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines](https://images-eureka.patsnap.com/patent_img/f6c87757-1e67-4d64-92b1-92c0f71d3ba7/US20020198380A1-20021226-C00003.png "Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines")
Owner:BOEHRINGER INGELHEIM PHARM KG
Amiopyrimidine-modified gold nano particles and preparation method and use thereof
ActiveCN102188383AHigh antibacterial activityEasy to prepareAntibacterial agentsPowder deliveryThiolNanoparticle
The invention provides series amiopyrimidine-modified gold nano particles. In the amiopyrimidine-modified gold nano particles, the amiopyrimidine may be one or more of 2-thiol-4,6-diamino-pyrimidine, 2-thiol-4-amino-pyrimidine and 2,4-diamino-6-mercaptopyrimidine. The particle size of the amiopyrimidine-modified gold nano particles is 1.5 to 10.0 nanometers; and the molar content ratio of amiopyrimidine molecules to gold element in the nano particles ranges from 0.1 to 0.9. The amiopyrimidine-modified gold nano particles have antibacterial effect, can be widely used for preparing antibacterial medicines such as anti-gram-negative bacilli penicillins medicines, anti-gram-positive bacterium medicines or / and anti-multi-medicine-resistance clinically isolated bacterium medicines. The invention also provides the preparation method and use of the amiopyrimidine-modified gold nano particles. The invention further provides antibacterial medicines containing the amiopyrimidine-modified gold nano particles.
Owner:重庆龙翼生物科技有限公司
Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidine compound and composition containing same
ActiveCN106188138AEnhanced inhibitory effectGood pharmacokinetic parametersOrganic active ingredientsMetabolism disorderDiaminopyrimidineCurative effect
The invention provides a diaminopyrimidine compound and a composition containing the same and discloses the diaminopyrimidine compound shown as in a formula (I) and a drug combination containing the compound or salt thereof acceptable in crystal form and pharmacy, hydrate or solvent complex, stereoisomer, pro-drug or isotope variant. The diaminopyrimidine compound and the composition containing the same have excellent inhibition effect on protein kinase and have better pharmacokinetic parameter characteristics, and drug concentration of the compound in animal bodies can be increased to improve drug efficacy and safety.
Owner:SHENZHEN TARGETRX INC
2,4-diamino-pyrimidine compounds and method for making and using the compounds
Compounds within the scope of the present invention have a Formula 1or a salt or prodrug thereof, where ring A is selected from cycloaliphatic; ring B is aryl; R1 is selected from (C1-C10)alkyl, (C3-C10)cycloalkyl, halo, aryl, and heteroaryl; and R2 and R3 are independently selected from hydrogen and (C1-C6)alkyl. Disclosed compounds may have an IRAK4 IC50 of from 0.003 μM to 3.7 μM; a TAK1 IC50 of from 0.008 μM to 132 μM; and / or an IRAK4 / TAK1 selectivity of from 1 to 450. Particular compounds may have an IRAK4 / TAK1 selectivity of from 100 to 500. Disclosed compositions may be formulated as pharmaceutical compositions. A method for using the compounds and / or compositions also are disclosed. The method may comprise administering to a subject an effective amount of a compound within the scope of the present invention, particularly to selectively inhibit IRAK 1 and / or IRAK4 over TAK1.
Owner:RIGEL PHARMA
Hair-growing composition and application thereof
InactiveCN107550749APromote opennessPromote proliferationCosmetic preparationsHair cosmeticsFiberPotassium
The invention discloses a hair-growing composition and application thereof. The hair-growing composition is mainly prepared from the following components in parts by mass: 0.1 to 5 parts of pyrrolidyldiaminopyrimidine oxide and 0.1 to 5 parts of dimethyl sulfone, wherein the pyrrolidyl diaminopyrimidine oxide can promote the telophase in the hair life cycle to be changed into anagen; the dimethylsulfone provides an organic sulfur nutrient source as a necessary condition for the synthesis of keratin fibers and also can remove free radicals and inhibit inflammation; by combined use of the twosubstances, multiple effects of promoting blood circulation, opening potassium channels, and promoting the proliferation of hair follicle cells and the expression of human keratin fibers can be realized; a good hair growth effect is achieved from inside to outside.
Owner:广州汀兰生物科技有限公司
Process for synthesis of phenoxy diaminopyrimidine derivatives
A method for preparing a compound of formula kor a salt or solvate thereof,wherein R1 is as defined herein,the method comprising treating a compound of formula jor a salt or solvate thereof,with ammonia, to form the compound of formula k.
Owner:ROCHE PALO ALTO LLC
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the compounds being of formula (I):wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Production method of diaminopyrimidine compounds
The present invention relates to a novel production method of a diaminopyrimidine compound useful as an intermediate for various compounds having a pharmacological activity, a novel intermediate useful for producing said compound, and a production method of the intermediate.The present invention provides a novel 5-aminopyrimidine compound represented by the following formula (2) and a novel 4,5-diaminopyrimidine compound represented by the formula (3), as well as production methods of the compounds of the following formulas (2) to (6).wherein each symbol is as defined in the specification.
Owner:AJINOMOTO CO INC
Substituted diaminopyrimidine compound, composition comprising compound and application of compound
InactiveCN106146406AEnhanced inhibitory effectGood pharmacokinetic parametersOrganic active ingredientsAntipyreticTherapeutic effectSolvent
The invention provides substituted diaminopyrimidine compound, a composition comprising the compound and application of the compound. The substituted diaminopyrimidine compound is diaminopyrimidine compound shown as in formula (I) or its crystal-form pharmaceutically acceptable salts and prodrugs, and stereoisomer, hydrate or solvent compound. The substituted diaminopyrimidine compound disclosed herein and the composition comprising the compound have excellent inhibitory action on EGFR (epidermal growth factor receptor) kinase, have better pharmacokinetics parameter characteristics, and can increase the drug concentration of the compound in an animal body to provide improved drug therapeutic effect and safety.
Owner:SHENZHEN TARGETRX INC
Substituted diaminopyrimidine compound and application thereof in preparation of antineoplastic drugs
ActiveCN106831730AHigh selectivityGood pharmacokinetic propertiesOrganic active ingredientsOrganic chemistryEGFR T790MDiaminopyrimidine
The invention provides a substituted diaminopyrimidine compound and medicinal salt thereof. The structure of the substituted diaminopyrimidine compound is as shown in a general formula (I). A pharmacodynamic test proves that the compound is capable of effectively inhibiting growth of multiple tumor cells and can be used for preparing anti-tumor drugs, and meanwhile, the drug resistance of EGFR T790M can be overcome.
Owner:药谷(温州)科技发展有限公司
Process for synthesis of phenoxy diaminopyrimidine derivatives
A method for preparing a compound of formula Ithe method comprising treating a compound of formula dwith an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.
Owner:ROCHE PALO ALTO LLC
Anti-hair loss and hair-strengthening nutrient solution and preparation method thereof
PendingCN111803426AInhibit growthHair growth prevention as well as promotion ofCosmetic preparationsHair cosmeticsBiotechnologyTG - Triglyceride
The invention relates to an anti-hair loss and hair-strengthening nutrient solution and a preparation method thereof. The anti-hair loss and hair-strengthening nutrient solution is prepared from the following raw material components in parts by weight: 80 to 90 parts of compound plant extract, 5 to 9 parts of a hair conditioner, 3.5 to 10 parts of a humectant and 0.2 to 0.4 part of a thickening agent, wherein the composite plant extract is a mixture of water, a cacumen biotae extract, a radix polygoni multiflori extract, a ginger root extract, a folium mori extract, a black mulberry fruit extract, a sesame seed extract and a ginseng root extract, and the hair conditioner is a mixture of water, propylene glycol, glycerol, 1, 2-hexanediol, diaminopyrimidine oxide, polyglycerol-6 myristate, caprylic / capric triglyceride, pyrrolidinyl diaminopyrimidine oxide, lecithin, hydroxylated lecithin and cholesterin. The anti-hair loss and hair-strengthening nutrient solution has good effects of strengthening and toughening hair roots, preventing hair loss and promoting hair growth.
Owner:广州市逸轩精细化工有限公司
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Owner:ROCHE PALO ALTO LLC
2, 4-diaminopyrimidide derivates and their use for the treatment of cancer
The present invention encompasses compounds of general formula (1) wherein Q and R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
Owner:BOEHRINGER INGELHEIM INT GMBH
2,4-diaminopyrimidine compounds useful as immunosuppressants
InactiveUS7101869B2Ease of detectabilityEasy to prepareBiocideOrganic chemistryAutoimmune conditionTransplant rejection
Novel compounds according to the formula and pharmaceutically acceptable salts, solvates, or hydrates thereof; whereineach occurrence of A is independently selected from CH or N;X is selected from the group consisting of —CH2—, —O—, —NH—, (C1-C6)alkylamino-, (C1-C6)alkylaminocarbonylamino-, (C1-C6)alkylcarbonylamino-, (C1-C6)alkylsulfonylamino-, phenylsulfonylamino-, carbonyl, —NH—C(O)—, —N(C1-C6)alkyl-C(O)—, —S(O)y— where y is 0, 1 or 2, and;n in —(CH2)n— is 1, 2 or 3; andR1, R2, and R3 are as described herein; pharmaceutical compositions that including these compounds, and methods for the treatment of autoimmune disease, inflammation, allergy, transplant rejection, and other circumstances where administration of an immunosuppressive agent is of therapeutic benefit.
Owner:PFIZER INC
Methods of using diaminopyrimidine as p2x3 and p2x2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
Owner:ROCHE PALO ALTO LLC
Anti-loss hair-growth liquid and preparation method thereof
PendingCN110192995APromote hair growthMatching scienceCosmetic preparationsHair cosmeticsAdenosineGlycerol
The invention discloses an anti-loss hair-growth liquid and a preparation method thereof, a composition thereof comprises: a phase A comprising adenosine, nicotinamide, and water; a phase B comprisingdipotassium glycyrrhizinate and pyridoxine HCl; a phase C comprising an acrylate copolymer and water; a phase D comprising sodium hydroxide and water; a phase E comprising water, beeswax, hydroxyethyl behenamide propyl dimethyl ammonium chloride, behenyl alcohol, an avocado fruit extract, phenoxyethanol, ethylhexylglycerin, an apple fruit extract, a biota orientalis extract, a leaf extract of Ilex aquifolium, a mulberry leaf extract, and propylene glycol; a phase F comprising propylene glycol, the avocado extract, caffeine, beeswax, hydroxyethyl behenamide propyl dimethyl ammonium chloride, behenyl alcohol, phenoxyethanol, ethylhexyl glycerol, and water; a phase G comprising ethanol, biotin, pyrrole alkyl diaminopyrimidine oxide, and water; and a phase H comprising phenoxyethanol. The invention also provides a preparation method of the anti-loss hair-growth liquid. The anti-loss hair-growth liquid has the advantages of scientific ratio, safety, and non-toxic side effects, and can effectively promote hair growth.
Owner:石家庄健洛特网络科技有限公司
Pyrimidopyrimidine compound, nucleoside analog derivative thereof, preparation method thereof and use thereof
ActiveCN102516339AInhibitory activityPotential to inhibit replicationOrganic active ingredientsSugar derivativesChemical compoundDiaminopyrimidine
The invention relates to a pyrimidopyrimidine compound and a nucleoside analog derivative thereof. The pyrimidopyrimidine compound and the nucleoside analog derivative thereof prepared in the invention have certain hepatitis virus inhibition activities, and 4,7-diamino-1-(beta-2-deoxy-D-ribofuranose)pyrimido[4,5-d]pyrimidine-2,5(1H,6H)-dione and 4,7-diaminopyrimido[4,5-d]pyrimidine-2,5(1H,6H)-dione perform obvious virus copying inhibition potentials and are better than ribavirin, so a new selection is provided for clinical medicines.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
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