40 results about "Diaminopyrimidine" patented technology

The invention provides an anti-hair-loss and hair-growing product containing plant extract components and a preparation method thereof, and relates to the field of wash supplies, the anti-hair-loss and hair-growing product is prepared from the following raw materials by weight: 50-80 parts of water, 5-10 parts of propylene glycol, 1-5 parts of 1, 3-propylene glycol, 1-5 parts of 1, 3-propylene glycol, and 1-5 parts of 1, 3-propylene glycol. The composition is prepared from the following components in parts by weight: 0.1 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of pyrrolidinyl diaminopyrimidine oxide, 0.1 to 0.5 part of diaminopyrimidine oxide, 0.01 to 0.02 part of caffeine, 0.01 to 0.1 part of adenosine, 0.05 to 0.2 part of vitamin B6, 0.01 to 0.5 part of biotin tripeptide-1, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.02 to 0.05 part of ethylenediamine tetraacetic acid, 0.1 to 1 part of D panthenol, 0.2 to 1 part of p-hydroxyacetophenone, 0.01 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of 2, 2-pentanediol, 0.1 to 1 part of 2, 2-pentanediol, 0.1 to 1 part of 2, 2- The composition comprises the following components in parts by weight: 1-2 parts of 1, 2-hexanediol, 0.1-0.5 part of citric acid, 1-2 parts of 1, 3-butanediol, 0.01-1 part of NMN and 3-5 parts of a plant extract. According to the present invention, the extraction method of the plant extract in the raw materials is specifically adjusted so as to significantly reduce the content of the pigment and the odor substance in the extract, such that the obtained hair growing liquid has characteristics of good hair growing effect, light color and light drug taste, can be easily accepted by consumers, and is suitable for large-scale promotion and application.

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, niacinamide, and at least 1% by weight of a particular hydroxylated compound. The invention also relates to a cosmetic treatment method for human keratinous materials such as skin, particularly scalp, hair, and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention. The present invention further relates to the use of said cosmetic composition to treat hair loss and / or promote the regrowth of keratin fibers.

The present invention provides a pharmaceutical composition comprising (S)—N-(1-(2-((4-amino-3-nitrophenyl)amino)-6-propylpyrimidin-4-yl)pyrrolidin-3-yl)acetamide, which has activity as a 5-HT4 receptor agonist, or a pharmaceutically acceptable salt thereof, and an acidifying agent, as well as a method for preparing the same.

The present application relates to the field of hair preparations, in particular to a composition with anti-hair loss and oil control functions and a preparation method thereof.The raw materials of the composition include diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide, lactobacillus / soybean milk fermentation product filtrate combined with PPG-13-decyltetradecinol polyether-24, PPG-70 polyglyceryl-10 ether, African neem bark extract, Anemarrhena asphodeloides root extract, Panax ginseng root extract, Zingiber officinale root extract, Polygonum multiflorum root extract, humectant, emollient and water.The composition has excellent anti-hair loss and oil control effects, high stability and can still exist stably in a high temperature environment.

The invention provides a diaminopyrimidine compound as shown in a formula I. The compound can be used as a three-mutant type (sensitive mutation / T790M / C797S) EGFR (epidermal growth factor receptor) kinase inhibitor and is used for preventing and / or treating tumors.

The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.

The invention relates to the technical field of hair loss preventing and hair growing compositions, and discloses a hair loss preventing and hair growing composition and a preparation method and application thereof.The hair loss preventing and hair growing composition comprises a core active ingredient which is diaminopyrimidine oxide; the plant extract is selected from at least one of a ginseng root extract, a cacumen biotae extract, a polygonum multiflorum extract, a rosemary extract, a cordyceps sinensis extract and a tuber melanosporum extract; a porous support material. According to the composition, the core active component and the specific plant extract are jointly loaded in the porous carrier material, so that the skin retention volume and permeation efficiency of the active component after local application to scalp are remarkably improved, and more lasting and more efficient targeted delivery is realized, so that the anti-hair loss and hair growth effects are enhanced, and the anti-hair loss and hair growth effects are improved. The problems that active ingredients in a traditional preparation are easy to lose and the transdermal absorption is poor are solved.

The present invention relates to a salt of 5-((2-ethynyl-5-isopropylpyridin-4-yl)oxy)pyrimidine-2,4-diamine and a solid form thereof, a method for preparing the solid form and a pharmaceutical composition comprising the solid form, as well as a use of the solid form for preventing or treating diseases modulated by P2X3 and / or P2X2 / 3 receptor antagonists.

The invention discloses a 2, 4-diaminopyrimidine-6-heteroaromatic pyrimidine compound and application thereof, and the 2, 4-diaminopyrimidine-6-heteroaromatic pyrimidine compound has the following structural general formula as shown in the specification, wherein W, X, Y and Z are independently selected from hydrogen or nitrogen. The 2, 4-diaminopyrimidine-6-aromatic heterocyclic pyrimidine compound designed and synthesized by the invention is a novel NF-kappa B induced kinase (NIK) inhibitor, and is suitable for drug development taking NIK as a target spot, and the obtained drug can be used for treating malignant tumors such as leukemia, multiple myeloma glioma and the like.

The present invention relates to a solid form of 5-((2-ethynyl-5-isopropylpyridin-4-yl)oxy)pyrimidine-2,4-diamine or a hydrate thereof, a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and a use of the solid form for the prevention or treatment of a disease modulated by P2X3 and / or P2X2 / 3 receptor antagonists.

The invention provides a diaminopyrimidine compound with a structure as shown in a formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug molecule thereof, or a deuteride thereof, or a tritium thereof, and an application of the diaminopyrimidine compound, or the stereoisomer thereof, or the pharmaceutically acceptable salt thereof, or the solvate thereof, or the prodrug molecule thereof, or the deuteride thereof, or the tritium thereof. The diaminopyrimidine compound provided by the invention has obvious inhibitory activity on RSV virus, has a chemical structure type completely different from that of the existing anti-RSV drug ribavirin and the like, is expected to be developed into a novel anti-RSV drug, is used for inhibiting replication or reproduction of the RSV virus, and has broad application prospects. The pharmaceutical composition can be used for preventing, relieving and / or treating respiratory syncytial virus infection and cytopathic effects caused by the respiratory syncytial virus infection, and can be used for treating bronchitis or pneumonia and other diseases caused by the respiratory syncytial virus infection.

The invention discloses a high-strength wear-resistant fastener and a preparation process thereof, and relates to the technical field of fastener preparation. According to the preparation method, dipentaerythritol and 1, 1, 1-trifluoro-2, 3-epoxypropane are taken as raw materials to prepare polyfunctional fluorine-containing polyol, then double-bond-containing polyfunctional polyurethane acrylate and a macromolecular photoinitiator are respectively prepared through the polyfunctional fluorine-containing polyol, and molybdenum disulfide is modified through 2, 4-dimercapto-5, 6-diaminopyrimidine, so that the photoinitiator is prepared. The preparation method comprises the following steps: preparing functional molybdenum disulfide, blending double-bond-containing polyfunctional polyurethane acrylate, the functional molybdenum disulfide and a macromolecular photoinitiator to obtain composite polyfunctional polyurethane acrylate, mixing the composite polyfunctional polyurethane acrylate with an auxiliary agent to obtain a wear-resistant coating, coating the surface of a copper-plated fastener with the wear-resistant coating, and performing ultraviolet curing to obtain the wear-resistant copper-plated fastener. And the formed wear-resistant coating has the properties of high wear resistance, high impact strength and the like.

The present disclosure provides indanol substituted diamino pyrimidine carboxamides compounds of Formula I, its pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, stereoisomers, polymorphs, or pharmaceutically active derivatives thereof as dual ATM / DNA-PK inhibitors. The present disclosure further provides compounds of Formulae la, lb, and Ic, its pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, stereoisomers, polymorphs, or pharmaceutically active derivatives thereof. The present disclosure also provides process of preparing said compounds and methods thereof.

The invention discloses a composition and application of the composition in products for reducing alopecia. The composition disclosed by the invention is prepared from one or more of a cacumen biotae extract, diaminopyrimidine oxide and p-hydroxyacetophenone. The composition disclosed by the invention has a quick effect and a lasting and effective anti-hair-loss effect.

The invention discloses a nitrogen heterocyclic ring-containing compound and a preparation method and application thereof, and the preparation method of the compound comprises the following steps: carrying out condensation reaction on 2, 5-diaminopyrimidine and 2, 6-dimethyl-4-nitrochlorobenzene under the action of alkali to obtain an intermediate 1; and introducing hydrogen into the intermediate 1 and 5-methyl-2-hexanone under the action of a catalyst to carry out reductive condensation reaction to obtain a product. The compound has a special structure, contains pyrimidine and benzene ring groups, has a good ozone protection effect when being used in rubber products, has different substituent groups on benzene rings, does not generate p-benzoquinone or o-benzoquinone toxic substances, is higher in environmental protection property and large in molecular weight, is not easy to discolor and emigrate when being used in the rubber products, and has a good application prospect. And the anti-aging agent has high application value in the aspect of aging resistance of rubber materials.

The invention relates to the technical field of biological medicine, in particular to a 2, 4-diaminopyrimidine compound containing tetrahydrobenzothiazolyl and application of the 2, 4-diaminopyrimidine compound. The invention provides a tetrahydrobenzothiazolyl-containing 2, 4-diaminopyrimidine compound with a structure as shown in a formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof, and an application of the tetrahydrobenzothiazolyl-containing 2, 4-diaminopyrimidine compound. The tetrahydrobenzothiazolyl-containing 2, 4-diaminopyrimidine compound disclosed by the invention has obvious inhibitory activity on cyclin-dependent kinase 2 (CDK2), has an obvious treatment effect on diseases related to the cyclin-dependent kinase 2, such as tumor diseases such as human colon cancer, and has no obvious side effect; the compound can be used for preparing new target candidate drugs for human colon cancer and other diseases.

To provide a novel process for preparing a diaminopyrimidine derivative or an acid addition salt thereof having an activity as a 5-HT4 receptor agonist, and also to provide novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.SOLUTION: Provided is crystal A of a hydrochloride of the compound of Chemical Formula 1 having an XRPD pattern having peaks at 2θ of 7.4°, 9.1°, 12.0°, 12.5°, 13.5°, 14.1°, 15.9°, 16.8°, 18.3°, 19.1°, 24.6°, 25.3°, and 26.8°±0.2°.SELECTED DRAWING: None

The application belongs to the field of medical cosmetics, and particularly relates to an active substance combination with skin penetration promotion and hair follicle activity improvement and application thereof. Diaminopyrimidine oxide, caffeine, cellulose, plant cholesterol, taurine, HUMULUS LUPULUS extract, 17-type collagen short peptide and water are proportionally mixed to prepare a hair follicle repair liquid, which not only effectively reduces the harm of chemical substances to the scalp and human body, but also further enhances the effect of the repair liquid in promoting hair growth and improving hair follicle activity.

The present application provides a kind of diaminopyrimidine compound shown in formula I, and the compound can be used as three mutant (sensitive mutation / T790M / C797S) EGFR kinase inhibitor for preventing and / or treating tumor.

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, caffeine, and at least 0.5% by weight of a particular hydroxylated compound. The invention also relates to a cosmetic treatment method for human keratinous materials such as skin, particularly scalp, hair, and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention. The present invention further relates to the use of said cosmetic composition to treat hair loss and / or promote the regrowth of keratin fibers.

The present invention relates to a 2,4-diaminopyrimidine derivative, pharmaceutically acceptable salts thereof, hydrates, solvates or stereoisomers, and a preparation method thereof and an application of the compound used separately or in combination with other drugs in treating diseases having ALK2 kinase-mediated pathological features

A method for treating, resisting and alleviating endometriosis-associated pain, relating to the field of biological medicine, comprising administering, to an individual in need thereof, a therapeutically effective amount of a diaminopyrimidine compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.

Provided are a novel compound suitable for a microporous network complex, a microporous network complex, a method for producing a sample for crystal structure analysis, and a method for determining a molecular structure. This compound is a 4,6-diamino-5-pyrimidinecarbonitrile derivative represented by, for example, general formula (1A). (In general formula (1A), regarding X1 moieties, any one of the X1 moieties is a nitrogen atom and the others are each CH, or any two of the X1 moieties are nitrogen atoms and the others are each CH; and Y1 represents one divalent group selected from the group consisting of optionally substituted arylene groups, optionally substituted heteroarylene groups, a single bond, optionally substituted alkylene groups, optionally substituted cycloalkylene groups, optionally substituted alkenylene groups, optionally substituted alkynylene groups, and -C(=O)- or represents a divalent group that is a combination of two or more groups of the same or different kinds which are selected from the above-mentioned group.)

The invention relates to the field of hair washing and caring products, in particular to a supramolecule with oil control and hair loss prevention effects, a preparation method of the supramolecule and a hair washing and caring product. The invention discloses a supramolecule with oil control and hair loss prevention effects. The supramolecule comprises a hair loss prevention component and dicarboxylic acid, the anti-shedding component has an amino group, and the amino group of the anti-shedding component and the carboxyl group of the dicarboxylic acid form a eutectic structure through an intermolecular hydrogen bond; the amino group in the anti-hair loss component is used as a hydrogen bond donor, and the carboxyl group in the dicarboxylic acid is used as a hydrogen bond acceptor; according to the technical scheme, the whole anti-hair loss effect and the oil control effect of the supramolecule far exceed the anti-hair loss effect of single diaminopyrimidine oxide or pyrrolidinyl diaminopyrimidine oxide; or the oil control effect of dicarboxylic acid; more importantly, the supramolecule provided by the invention has excellent solubility and compatibility, is mild and has no side effect, so that the supramolecule can be well compounded in hair washing and care products to play a role.

The application discloses a kind of pyrimidine-based covalent organic polymer materials and its preparation method and its application in photocatalytic production of hydrogen peroxide.The material is prepared by solvothermal method: 2,4-diaminopyrimidine is dispersed with benzene-1,3,5-tricarboxaldehyde in solvent, acetic acid aqueous solution is added and ultrasonic mixed uniformly;System is degassed after three "freeze-vacuum-thaw" cycle at liquid nitrogen temperature, melt seal glass tube, constant temperature reaction for a period of time.The preparation process provided by the application is simple, the obtained material has excellent interface charge transport capacity and high efficient photo-generated carrier separation efficiency, can produce hydrogen peroxide under light condition, the yield reaches 4167.5 μmol / g per hour, has good application prospect.

The present invention belongs to the field of biotechnology. More specifically, it relates to a new use of bakuchiol, specifically to the use of bakuchiol in enhancing the anti-hair loss efficacy of diaminopyrimidine oxides and their derivatives, wherein the diaminopyrimidine oxides and their derivatives are 2,4-diaminopyrimidine-3-oxide, 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, or 6-pyrrolidinyl-2,4-diaminopyrimidine-3-oxide.

The application relates to the technical field of chemical medicines, in particular to a kind of dianilopyrimidine macrocycle containing crown ether fragment and its preparation method and application.A series of dianilopyrimidine macrocycle containing crown ether fragment is synthesized in the application, and the problem of poor clinical effect of drug in current brain glioma treatment is overcome.The series of compounds have good inhibitory activity on brain glioma, and are suitable for treating brain glioma and related drug research and development.Moreover, the drug is widely distributed in vivo and is rapidly cleared, so that the possibility of drug accumulation poisoning is avoided;oral bioavailability is moderate (F=18.7%);these findings highlight the advantages and challenges of the pharmacokinetic characteristics of compound 13, and lay a foundation for further optimizing and improving the in-vivo stability and bioavailability strategy.

Provided in the present application are a diaminopyrimidine compound having a structure as represented by formula (I), or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug molecule thereof, a deuterated derivative thereof or a tritiated derivative thereof, and the use thereof.