26 results about "Bronchitis" patented technology

The present disclosure relates to RNA molecules encoding a respiratory syncytial virus (RSV) polypeptide. The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the treatment and / or prevention of RSV infection-induced acute respiratory tract illness, including pneumonia and bronchitis.

The present application relates to a kind of traditional Chinese medicine composition for treating acute exacerbation of chronic bronchitis, the traditional Chinese medicine composition is made of the following weight parts of raw medicinal materials: 10-14 parts of pinellia ternata, 7-11 parts of apricot kernel, 7-11 parts of persicae semen, 7-11 parts of dried tangerine or orange peel, 10-14 parts of radix codonopsis, 13-17 parts of oyster shell, 13-17 parts of concha mactrae, 13-17 parts of ophiopogon japonicus, 7-11 parts of radix clematidis, 1-5 parts of soap plant thorn.The present application is mainly used for treating syndrome of phlegm-dampness accumulating in lung;Effect: dry dampness and resolve phlegm, regulate qi and relieve cough;The monarch drug pinellia ternata in the present application is pungent, flat, warm and dry, and is good at dry dampness and resolve phlegm, and can descend adverse qi and relieve panting.Peach kernel and apricot kernel are used as ministers, which is a wonderful use of qi-blood confrontation: peach kernel enters blood and regulates qi, and apricot kernel enters qi and regulates blood, and the two are complementary, helping pinellia ternata to rotate qi and restore ascending and descending. The use of auxiliary drugs has three meanings: one is to attack evil, radix clematidis can pass through twelve meridians and remove phlegm, soap plant thorn is sharp and can break and soften, and is good at attacking stubborn phlegm. The combination of various drugs can attack and tonify, and is suitable for moistening dryness, and can achieve the effect of dry dampness and resolve phlegm, regulate qi and relieve cough.

The present invention provides an antibody or a conjugated fragment of a citrulline-containing epitope used for the treatment or prevention of diseases associated with the release of extracellular traps from cells, such as neutrophil extracellular trap (NET)-associated pathology (NET-associated pathology) or eosinophil extracellular trap (EET)-associated pathology (EET-associated pathology), and provides a method comprising administering at least one dose of the antibody at a specific concentration. The present invention also provides the method itself. NET-related pathologies include systemic lupus erythematosus (SLE), lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, myositis (polymyositis and dermatomyositis), Sjögren's disease, antiphospholipid syndrome, Behçet's disease, spondylitis, spondyloarthritis, multiple system atrophy, Parkinson's disease, Lewy body dementia, asthma, allergic rhinovirus exacerbated asthma, allergic asthma, acute respiratory distress syndrome, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, heart failure, atherosclerosis, dry eye disease, uveitis, non-granulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, or wound healing in diabetes, cancer, cancer metastasis, or wound healing in diabetes, cancer, cancer metastasis, and in This includes other NET-related pathologies, such as the health of transplanted organs in vivo or ex vivo.The present invention also relates to wound healing in SLE, lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, myositis (polymyositis and dermatomyositis), Sjögren's disease, antiphospholipid antibody syndrome, Behçet's disease, spondylitis, spondyloarthritis, multiple system atrophy, Parkinson's disease, Lewy body dementia asthma, allergic rhinovirus exacerbating asthma, allergic asthma, acute respiratory distress syndrome, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, heart failure, atherosclerosis, dry eye disease, uveitis, non-granulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, thrombotic disease, cardiovascular disease, or diabetes, cancer, cancer metastasis, or wound healing in diabetes, cancer, cancer metastasis, and in vivo or ex vivo The present invention provides pharmaceutical compositions and methods for treating and preventing NET-related pathologies, including other NET-related pathologies such as the health of transplanted organs in vivo. NET-related pathologies include eosinophilic diseases or conditions of the skin, respiratory eosinophilic diseases or conditions, gastrointestinal eosinophilic diseases or conditions, allergic diseases or conditions, or eosinophilic diseases or conditions such as helminthic, fungal, viral or bacterial infections.

A system for thermal regulation of a nebulizer is provided that is structured to deliver a chilled mist to the snout, muzzle, beak, or trunk of an animal. The system includes a container to house a nebulizer and a thermal material together and a mask to deliver the chilled mist to an animal. The thermal material acts to chill a liquid located inside the nebulizer in order to deliver a chilled mist to the animal for therapeutic purposes, such as initiating therapeutic hypothermia, or treating various respiratory illnesses such as croup, laryngobronchitis, and smoke inhalation.

The invention discloses a traditional Chinese medicine formula with functions of relieving cough and reducing sputum as well as a preparation method and application of the traditional Chinese medicine formula. The traditional Chinese medicine formula comprises the following traditional Chinese medicine components: radix asteris, flos farfarae, rhizoma pinellinae praeparata, perilla frutescens, herba epimedii, radix rehmanniae preparata, cudweed herb, herba ardisiae japonicae, wedelia chinensis and ginseng. Through different preparation methods, the traditional Chinese medicines can be prepared into different dosage forms such as traditional Chinese medicine cigarettes, traditional Chinese medicine oral liquid, traditional Chinese medicine concentrated pills and traditional Chinese medicine tablets so as to meet the requirements of different patients. Compared with the prior art, the traditional Chinese medicine formula disclosed by the invention is prepared from natural traditional Chinese medicines, has no obvious side effect and is safe and reliable to a human body. The traditional Chinese medicine composition has obvious cough-relieving and sputum-reducing effects, especially has obvious cough-relieving and sputum-reducing effects on cough and excessive sputum caused by cold, cough and asthma, bronchitis, pneumonia, lung abscess, white lung, long-term smoking and deficiency of lung, spleen and kidney, and can be used for removing sputum, including pus sputum, old sputum and viscous sputum, accumulated in lung bronchus. The traditional Chinese medicine has effects on old and new coughs, wind cold, wind heat and rheumatic coughs.

The present invention relates primarily to JAK1 pathway inhibitors for use in the treatment of chronic lung allograft dysfunction, in particular to JAK1 pathway inhibitors and their use in the treatment of chronic lung allograft dysfunction, such as for example bronchiolitis obliterans syndrome.

To provide compositions for treating and / or preventing RSV infection-induced acute respiratory tract illness including pneumonia and bronchitis.SOLUTION: The disclosure provides a composition for inducing immune response to RSV, the composition comprising an RNA molecule comprising at least one open reading frame encoding a respiratory syncytial virus (RSV) fusion protein F (F) polypeptide. The disclosure further relates to a composition comprising the RNA molecule formulated in a lipid nanoparticle (RNA-LNP). The disclosure further relates to the use of the RNA molecule, RNA-LNP, and composition for treating and / or preventing RSV infection-induced acute respiratory tract illness including pneumonia and bronchitis.SELECTED DRAWING: None

The present invention relates to RNA molecules encoding respiratory syncytial virus (RSV). The invention further relates to a composition comprising said RNA molecule (RNA-LNP) formulated in a lipid nanoparticle. The invention further relates to the use of said RNA molecule, said RNA-LNP and said composition for the treatment and / or prevention of RSV infection-induced acute respiratory tract conditions, including pneumonia and bronchitis.

The present invention relates to oligosaccharide formulations for treating, alleviating, preventing and / or delaying respiratory diseases, preferably infectious bronchitis and / or their action.

A problem to be solved by the present invention is to find a component for preventing the onset of bronchitis from breast milk, to provide a novel nutritional composition. The present invention relates to a nutritional composition for preventing the onset of bronchitis wherein N-acetylneuraminic acid, 6'-sialyllactose, α-2,6-disialo N-linked glycan, or a disialo N-linked glycan with a specific structure are contained as active ingredients. This nutritional composition is an effective composition not only for infants but also for elderly people and people with underlying diseases who are at high risk of contracting the bronchitis, so the composition is efficacious as the nutritional composition for preventing the onset of bronchitis when it is added to foods and nutritional compositions for adults and the elderly.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating lung injury caused by low pressure and low oxygen, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 2 parts of rhododendron anthopogonoide, 1 part of cardamom and 1 part of galangal. The traditional Chinese medicine composition not only has the functions of soothing the liver, invigorating the stomach, strengthening the body resistance, but also has good effects of improving lung functions and preventing lung injury. From the Tibetan medicine prescription theory, the rhododendron anthopogonoide is a monarch drug and has the effects of inducing diuresis to alleviate edema, clearing away lung heat and improving bronchitis; the cardamom is a ministerial drug and has the effects of dispelling cold, warming kidney and astringing pulse orifices; the galangal is an adjuvant drug and has the effects of warming the stomach and improving the functions of the spleen and the stomach. Through reasonable compatibility of the three medicinal materials, the effects of improving the stomach function, promoting digestion and absorption, improving immunity, clearing away the lung-heat, diminishing swelling, clearing heat and resisting inflammation can be achieved.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a preparation method and application thereof. According to the preparation method, the traditional Chinese medicine composition and the preparation thereof provided by the invention, the extraction transfer rate of active effective components of the prescription medicines is improved; the traditional Chinese medicine composition can be used for reducing body temperature, resisting viruses, and / or treating cold and cough, upper respiratory tract infection, acute and chronic tracheal and bronchitis, pneumonia, bronchial asthma, measles combined pneumonia, children pertussis and / or pungent and cool catharsis, clearing lung and relieving asthma, and relieving cough and reducing phlegm.

Disclosed herein are methods of treating a disease selected from the group consisting of graft versus host disease (GVHD), systemic sclerosis (scleroderma), chronic lung allograft dysfunction (CLAD), restrictive allograft syndrome (RAS), and obliterated bronchitis syndrome (BOS), using a combination of a BTK inhibitor, such as rezobrutinib, and besudil.

The present invention relates to a compound of formula (I) wherein R1 and R2 are as defined herein, a pharmaceutical composition comprising such compound for treatment of a PGD2-mediated disorder including, to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

The present invention relates to a pharmaceutical composition for treating and preventing allergic bronchitis, comprising a perilla leaf extract as an active ingredient, and a preparation method therefor, and can be used as functional health food and feed compositions for preventing and alleviating allergic bronchitis.

The present disclosure relates generally to the treatment of patients with chronic lung allograft dysfunction (CLAD) following lung transplantation, with bronchiolitis obliterans syndrome (BOS) following lung transplantation, or with bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic stem cell transplantation, by administering belumosudil.

The present invention refers to an agent for use in the prevention and / or treatment of lung pathological conditions associated with loss of alveolar epithelial type II to type I trans- differentiation capacity and / or with loss of lung regenerative capacity and / or for use in promoting lung regeneration in a subject with a lung pathological condition, said agent being selected from the group consisting of: an inhibitor of miR-210-3p and an inhibitor of miR-155- 5p or a combination thereof, wherein said lung pathological condition is selected from the group consisting of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia, desquamative interstitial pneumonia, respiratory bronchiolitis-ILD, cryptogenic organizing pneumonia and acute interstitial pneumonia, chronic obstructive pulmonary disease, post-acute respiratory distress syndrome, and post-acute COVID-19 syndrome.

This disclosure relates to RNA molecules encoding respiratory syncytial virus (RSV). This disclosure further relates to compositions comprising RNA molecules formulated in lipid nanoparticles (RNA-LNPs). This disclosure further relates to the use of RNA molecules, RNA-LNPs, and compositions for the treatment and / or prevention of RSV infection-induced acute respiratory tract diseases, including pneumonia and bronchitis.

The invention relates to the technical field of preparation of bath foam, and particularly discloses bath foam capable of relieving cough and a preparation method of the bath foam. The bubble bath liquid capable of relieving cough is prepared from 215 to 505 parts of water, 38.5 to 91 parts of glycerol, 3 to 8 parts of poria cocos extract, 1 to 5 parts of almond extract, 3 to 8 parts of citrus peel extract, 8 to 12 parts of folium eriobotryae extract, 3 to 8 parts of perilla leaf extract, 3 to 8 parts of liquorice root extract, 0.5 to 1.5 parts of eucalyptus globulus oil, 0.5 to 1.5 parts of Chinese honey locust seed extract and 1.4 to 3.24 parts of p-hydroxyacetophenone. The traditional Chinese medicine composition has the effects of relieving cough, moistening lung, reducing phlegm, clearing damp phlegm, clearing lung qi, reducing lung fire and relieving bronchitis, and can relieve lung discomfort caused by children cough and unsmooth breath and symptoms such as cough, excessive phlegm and bronchitis.

The invention belongs to the technical field of medicaments, and particularly relates to a cough and asthma medicament for treating rheumatism and a preparation method thereof, the technical scheme is that the cough and asthma medicament for treating rheumatism is prepared from safflower, ligusticum wallichii, cinnamon, pseudo-ginseng, oyster, fingered citron, Chinese yam, ginkgo, sea-buckthorn, peach kernel, platycodon grandiflorum, angelica sinensis, elecampane, malt, kudzu vine root, angelica dahurica, astragalus membranaceus, hawthorn, ginger, mulberry leaf, liquorice and selfheal. The cough and asthma treating medicine for rheumatism has the main conditioning effects on waist soreness, leg pain, numbness of four branches, sciatic nerves, scapulohumeral periarthritis and arthritis, lumbar muscle bailing injury, kicking injury, bronchitis, asthma, lung qi and lung, pulmonary heart disease, cold and cough caused by rheumatism and rheumatoid.

A system for thermal regulation of a nebulizer is provided that is structured to deliver a chilled mist to the snout, muzzle, beak, or trunk of an animal. The system includes a container to house a nebulizer and a thermal material together and a mask to deliver the chilled mist to an animal. The thermal material acts to chill a liquid located inside the nebulizer in order to deliver a chilled mist to the animal for therapeutic purposes, such as initiating therapeutic hypothermia, or treating various respiratory illnesses such as croup, laryngobronchitis, and smoke inhalation.

The present disclosure provides methods of treating chronic graft versus host disease (cGVHD) associated obliterated bronchiolitis syndrome using antibodies that bind to colony stimulating factor 1 receptor (CSF-1R).

The present invention relates to oligosaccharide preparations for treating, alleviating, preventing, and / or delaying respiratory diseases, preferably infectious bronchitis, and / or their effects.

Disclosed are methods for treating an individual at risk for developing bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplant (HSCT), comprising a) detecting a biomarker; b) quantifying a biomarker level; and c) comparing the level of a biomarker to a control value; wherein a deviation in a level of biomarker indicates that said individual is likely to develop the lung condition.

This invention relates to a traditional Chinese medicine composition for treating spasmodic cough in children. The composition is made from the following raw materials in parts by weight: honeysuckle 10-14 parts, earthworm 7-11 parts, cicada slough 4-8 parts, belamcanda chinensis 7-11 parts, scutellaria baicalensis 7-11 parts, honey-processed coltsfoot flower 7-11 parts, lily bulb 7-11 parts, ginger-processed bamboo shavings 7-11 parts, and licorice root 1-5 parts. This invention also provides the application of this traditional Chinese medicine composition in the preparation of a drug for treating spasmodic cough in children. In this formula, honeysuckle and earthworm are the principal herbs; cicada slough, scutellaria baicalensis, and belamcanda chinensis are the assistant herbs; ginger-processed bamboo shavings, coltsfoot flower, and lily bulb are the adjuvant herbs; and licorice root is the guiding herb. This formula treats cough with phlegm belonging to the wind-cold transforming into heat type. This invention promotes lung function, eliminates phlegm, relieves spasms, and stops cough. Main indications: spasmodic cough caused by pertussis, bronchitis, asthma, etc.