115 results about "Diuresis" patented technology

The invention relates to a traditional Chinese medicine composition for treating spleen-kidney qi deficiency and stasis toxin obstruction type diabetic nephropathy, which can effectively solve the medication problem for treating spleen-kidney qi deficiency and stasis toxin obstruction type diabetic nephropathy. The traditional Chinese medicine composition is prepared from, by weight, 37-33 g of astragalus membranaceus, 27-33 g of centella asiatica, 18-22 g of ligusticum wallichii, 18-22 g of winged euonymus twig, 18-22 g of salvia miltiorrhiza and 14-16 g of prepared rehmannia root. The traditional Chinese medicine composition is prepared by removing impurities from the raw materials, washing, airing, smashing and evenly mixing. The components are simple, scientific and reasonable, are compatible according to the main and secondary relationship of monarch, minister, assistant and guide, are mutually correlated and compatible in function to play a role, and are combined to play the roles of clearing heat and promoting diuresis, detoxifying and activating blood, reinforcing qi and nourishing yin, and tonifying kidney and replenishing essence, so that the traditional Chinese medicine is effectively used for preparing the medicine for treating spleen-kidney qi deficiency and blood stasis toxin blocking type diabetic nephropathy, and is good in curative effect and free of toxic and side effects. The traditional Chinese medicine composition is a great innovation of medicines for treating spleen and kidney qi deficiency and stasis toxin blocking collateral type diabetic nephropathy, and has remarkable social and economic benefits.

The invention belongs to the field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition with an anti-depression effect, which is prepared from the following medicinal materials by weight: 6g of pericarpium citri reticulatae viride, 6g of pericarpium citri reticulatae, 6g of radix paeoniae alba, 6g of thunberg fritillary bulb, 4.5 g of rhizoma alismatis, 4.5 g of fried gardenia and 4.5 g of moutan bark. The composition regulates functions of hypothalamus-pituitary-adrenal axis (HPA axis) and repairs hippocampal neurons and relieves symptoms such as pleasant sensation loss and behavioral despair of depression patients by relieving qi stagnation, clearing heat, cooling blood, promoting diuresis and reducing phlegm. Experiments prove that the traditional Chinese medicine composition can remarkably improve the sweet water preference rate of depression rats, shorten the forced swimming immobility time, reduce the levels of CRH, ACTH and CORT of plasma and improve pathological injuries of hippocampus tissues. The composition adopts medicinal and edible medicinal materials, is small in side effect and high in safety, and can be prepared into an oral preparation for treating depression.

The invention discloses a traditional Chinese medicine compound oral preparation for treating male oligoasthenospermia, and belongs to the technical field of traditional Chinese medicine preparations. The rhizoma polygonati processed with wine, the prepared rehmannia root and the like are used for nourishing the liver and kidney to consolidate congenital, the codonopsis pilosula, the astragalus membranaceus and the like are used for invigorating spleen and replenishing qi to complement postnatal, the fried cowherb seed is used for activating blood circulation, and the salted semen plantaginis is used for promoting diuresis, so that the problems of insufficient spermatogenesis and low vitality caused by deficiency of the spleen and the kidney are fundamentally solved. Experiments and clinical researches show that the preparation can significantly improve the sperm quantity, activity and activity rate of oligoasthenospermia model mice and patients, the clinical total effective rate reaches 90%, the pregnancy rate reaches 53.3%, and the curative effect is superior to that of Wuzi Yanzong pills in a control group. The action mechanism covers regulation of blood lipid metabolism, improvement of hypothalamus-pituitary-gonad axis functions, repair of testicular seminiferous tubule structural damage and reduction of lipid deposition, and meanwhile, oxidative stress and inflammatory injury are relieved and spermatogenic cell functions are protected by regulating and controlling a PPAR signal channel and inhibiting molecular pathways such as Cga / Sting mediated cell apoptosis.

The invention relates to a traditional Chinese medicine composition for treating cervical spondylosis and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 14.4 to 21.6 parts of radix astragali seu hedysari, 14.4 to 21.6 parts of radix paeoniae alba, 14.4 to 21.6 parts of caulis spatholobi, 14.4 to 21.6 parts of radix puerariae, 14.4 to 21.6 parts of ramulus mori, 7.2 to 10.8 parts of fructus lycii, 7.2 to 10.8 parts of rhizoma gastrodiae, 7.2 to 10.8 parts of rhizoma chuanxiong, 7.2 to 10.8 parts of radix clematidis, 7.2 to 10.8 parts of rhizoma alismatis, 7.2 to 10.8 parts of rhizoma atractylodis macrocephalae and 2.4 to 3.6 parts of radix notoginseng. The invention further provides a preparation method and application of the traditional Chinese medicine composition. Aiming at a compound syndrome type of liver and kidney deficiency combined with phlegm-damp collateral blocking cervical spondylosis, the rhizoma alismatis and bighead atractylodes rhizome pairs are introduced to achieve the effects of clearing damp, promoting diuresis, tonifying spleen and drying dampness together, and the traditional Chinese medicine is specially used for treating phlegm-damp dizziness and is matched with the rhizoma gastrodiae, so that the effects of reducing phlegm, stopping wind and stopping dizziness are remarkably enhanced. Meanwhile, ligusticum wallichii capable of promoting blood circulation and qi circulation is introduced to move upwards to relieve pain and forms synergistic compatibility with caulis spatholobi, herba clematidis and radix puerariae, and the traditional Chinese medicine composition is mild in medicine property, remarkable in curative effect, low in side effect risk and suitable for long-term nursing of cervical spondylosis.

The invention belongs to the field of pet food processing, and relates to a premix for improving joint health of pets and a preparation method thereof. The premix is added with the following natural components: rhizoma polygonati, rhizoma drynariae, eucommia ulmoides, ligusticum wallichii, liquorice, turmeric, poria cocos and Chinese yam. The whole formula has the effects of tonifying liver and kidney to consolidate the root, promoting blood circulation to remove meridian obstruction to treat symptoms, tonifying spleen to remove dampness to assist transportation and transformation, tonifying spleen to prevent dampness stagnation, promoting diuresis to prevent positive qi injury, treating both symptoms and root causes, combining dredging and tonifying, and directly reaching the effects on joints. The premix can tonify cartilage, strengthen ligament, relieve pain, supplement synovial fluid, effectively improve the arthritis health of pets and improve the life quality of pets.

Various systems, devices, components and methods are disclosed for controllably and selectively occluding, restricting, and / or diverting flow within a patient's vasculature. The flow restriction systems can include an implant having a flow restrictor and an implantable controller having an actuator for actuating the flow restrictor. The implants can be severable from their respective controller and actuator. The implants can include a dual frame configuration to prevent tissue ingrowth into at least one of the frames.

The invention provides a traditional Chinese medicine preparation for treating chronic prostatitis, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is prepared from black nightshade, hypericum perforatum, yam rhizome, rhizoma sparganii, common sage herb, chingma abutilon seed, polyporus umbellatus, uniflower swisscentaury root, corydalis amabilis, aspongopus, glossy privet fruit, fructus broussonetiae, radix ophiopogonis, tuber fleeceflower stem, day lily and liquorice. The traditional Chinese medicine preparation has the effects of clearing heat and promoting diuresis, promoting blood circulation to remove blood stasis, nourishing yin and soothing nerves and tonifying liver and kidney. The traditional Chinese medicine preparation disclosed by the invention has a remarkable treatment effect on CNP rats, and the prostate pathological injury condition and inflammatory response of the CNP rats are effectively relieved. In addition, the traditional Chinese medicine composition has a good treatment effect on relieving pain, frequent micturition, urgent urination, dysuria and other clinical symptoms and inflammation conditions of patients, and has a high total treatment effective rate on chronic prostatitis. The traditional Chinese medicine preparation provides a new scheme for treating chronic prostate.

A use of a diarylamide compound having the structure as shown in formula (I) or a pharmaceutically acceptable salt thereof in preparing a drug which acts as a urea transporter protein inhibitor, and a novel diarylamide compound. The diarylamide compound has urea transporter protein inhibitor effect, and can produce urea selective diuresis in the body without obvious toxicity.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating urolithiasis and preparation and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials and monomers in parts by weight: 10 to 30 parts of endothelium corneum gigeriae galli, 10 to 30 parts of rhizoma phragmitis, 10 to 30 parts of poria cocos, 10 to 20 parts of radix angelicae sinensis, 10 to 20 parts of herba cistanche, 10 to 20 parts of herba cepbalanoplosis segeti, 10 to 15 parts of fructus gardeniae, 5 to 10 parts of liquorice root and 1 to 6 parts of gossypotin 8-O-glucuronide. According to the traditional Chinese medicine theory of clearing heat, treating stranguria, dissolving stone and strengthening body resistance, modern pharmacological research is combined, scientific compatibility is carried out through chemical cutting, the synergistic effects of clearing heat, cooling blood, inducing diuresis, treating stranguria, dissolving stone, relieving pain, tonifying kidney and strengthening body resistance are achieved, the preparation process is efficient and controllable, and clinical application is safe and effective.

The invention discloses a traditional Chinese medicine composition for treating male prostatitis, which is prepared by extracting the following traditional Chinese medicines in parts by weight: 20-30 parts of radix paeoniae alba, 18-22 parts of radix curcumae, 15-25 parts of ligusticum wallichii, 10-20 parts of safflower, 15-25 parts of parasitic loranthus, 12-18 parts of semen cuscutae, 20-30 parts of codonopsis pilosula, 15-25 parts of poria cocos and the like. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, soothing the liver, regulating qi, tonifying the kidney, strengthening the spleen, calming the heart, clearing lung fire, resisting inflammation, clearing excess heat of upper jiao, clearing heat, promoting diuresis, treating stranguria and dissolving turbidity, has a remarkable effect on treating qi stagnation and blood stasis type chronic prostatitis, is easily accepted by patients and is superior to a control group.

The invention discloses a medicinal composition for strengthening body resistance and nourishing liver as well as a preparation method and application thereof. The preparation method of the composition comprises the following steps: weighing the 15 medicinal materials according to the formula amount, crushing the turtle shell, decocting for about half an hour, then adding the rest medicinal materials, decocting, filtering, and concentrating the water decoction to 1 / 3-1 / 5 of the water addition amount, thereby obtaining the traditional Chinese medicine composition. The healthy-energy-strengthening and liver-nourishing soup has the effects of inducing diuresis, nourishing the liver, relieving ascites due to cirrhosis and the like, can relieve the symptoms of patients suffering from cirrhosis due to deficiency of healthy energy, blood stasis and qi stagnation and water retention, and can be used for treating cirrhosis diseases. The prepared decoction is fast in oral administration absorption and fast in drug effect exertion. And the product has high safety and no adverse reaction.

The present invention discloses a traditional Chinese medicine composition for treating chronic bronchitis combined with emphysema. The composition is prepared by extracting the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of ginseng, 15-25 parts of astragalus, 20-30 parts of prepared rehmannia, 18-22 parts of schisandra, 15-25 parts of pinellia, and 20-30 parts of poria. The composition nourishes the liver, spleen, and kidneys, reduces stomach qi, purges the lungs, and relieves asthma, promotes diuresis and reduces swelling, promotes blood circulation and removes blood stasis, regulates qi and resolves phlegm, and is suitable for treating chronic bronchitis combined with emphysema. The present invention also discloses a preparation method and use thereof.

The invention provides a traditional Chinese medicine compound for relieving contrast agent acute kidney injury. The traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 10-30 parts of astragalus membranaceus; 4-8 parts of prepared rhubarb; 8-12 parts of coptis chinensis; 1-20 parts of semen plantaginis; 10-20 parts of codonopsis pilosula; 10 to 20 parts of fructus psoraleae; 8-12 parts of rhizoma dioscoreae hypoglaucae; 4-8 parts of glossy privet fruit; and 2-4 parts of liquorice. The invention further provides a preparation method of the traditional Chinese medicine compound for relieving contrast agent acute kidney injury. The invention further provides a traditional Chinese medicine compound extracting agent for relieving contrast agent acute kidney injury. Astragalus mongholicus is used as a monarch drug for tonifying qi and nourishing yin; the rhizoma coptidis is used for clearing away heat and toxic materials, and the semen plantaginis and the rhizoma dioscoreae hypoglaucae are used for resolving dampness and inducing diuresis; radix codonopsis tonifies qi, fructus psoraleae and glossy privet fruit tonify kidney; and liquorice blending. The whole formula can prevent and relieve the contrast agent acute kidney injury, and has the effect of protecting the kidney function.

The invention relates to the technical field of traditional Chinese medicine composition preparation and application, and discloses a traditional Chinese medicine composition for improving urinary tract infection and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from radix bupleuri, radix scutellariae, raw radix astragali, radix salviae miltiorrhizae, the root of Chinese pulsatilla, herba patriniae, polygonum aviculare, chingma abutilon seeds, the root of three-nerved spicebush, fennel, cinnamon and juncus roemerianus. The traditional Chinese medicine composition comprises the following components in parts by mass: 14-16g of radix bupleuri; 9 to 11 g of radix scutellariae; 19 to 21 g of raw radix astragali; 29 to 31 g of red sage root; 13-17g of Chinese pulsatilla root; 28-32 g of herba patriniae; 14-16 g of polygonum aviculare; 13 to 16 g of chingma abutilon seeds; 7-9g of combined spicebush root; 7-9g of fennel; 5-7g of cinnamon; according to the traditional Chinese medicine composition for strengthening the body resistance, clearing heat and promoting diuresis, the clearing curative effect on RUTI drug-resistant bacteria is better than that of antibiotics, the symptoms of a patient are obviously improved, the recurrence rate is lower than that of an antibiotic group, and the treatment principle and purpose of traditional Chinese medicine are completely different from those of antibiotic treatment; the traditional Chinese medicine composition disclosed by the invention considers recovery and improvement of the overall functional state of a patient instead of purely removing pathogenic bacteria.

The invention discloses a new application of fisetin and an application of a composition containing the fisetin. The new application comprises preparation of a medicine for treating hypertension, preparation of functional food or health care products for improving the blood pressure level, preparation of a medicine for reducing blood pressure, preparation of a medicine for inducing diuresis and discharging sodium and preparation of a preparation for reducing the Sik1 level. Experiments find that fisetin intervention can reduce the blood pressure of spontaneously hypertensive rats for the first time. The fisetin can increase the GSH-Px activity of the kidney, reduce the ROS level, improve the urinary sodium retention state by reducing the expression level of kidney Sik1 and further reduce the hypertension blood pressure level, and it is indicated that fisetin has the effect of preventing and / or treating primary hypertension and / or spontaneous hypertension. The invention provides application of fisetin in reducing hypertension, and provides a new thought for preventing and treating primary hypertension and / or spontaneous hypertension by reducing blood pressure.

The invention discloses a traditional Chinese medicine composition for treating uroschesis caused by benign prostatic hyperplasia and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared by mixing leeches, radix semiaquilegiae, cortex phellodendri, rhizoma anemarrhenae, Chinese lobelia, polygonum cuspidatum, herba patriniae, dianthus superbus, cowherb seeds, lumbricus, pericarpium citri reticulatae viride and lindera aggregata and then decocting with water. According to the traditional Chinese medicine composition, treatment is carried out synergistically from the three aspects of rapid relieving of emergency symptoms, targeted treatment of pathologic roots and synchronous recovery of whole body metabolic balance, and the four-in-one comprehensive curative effect of diuretic, anti-male, anti-inflammatory and tissue repair is achieved; the traditional Chinese medicine composition is simple in preparation method, low in cost and wide in safety window, is applied to treatment of uroschesis caused by benign prostatic hyperplasia, and provides a family-friendly traditional Chinese medicine solution capable of replacing or being combined with existing chemical medicines for patients.

The invention provides a scented tea composition for relieving urgent urination and frequent urination and application of the scented tea composition, and belongs to the technical field of health-care food. The scented tea composition comprises the following raw materials: 1-9 parts of Longjing tea, 1-9 parts of magnolia flower, 1-5 parts of Taihu Lake Cuiya, 1-5 parts of small orchid and 1-5 parts of Baoflood tea, the raw materials synergistically play a role in relieving urgent urination and frequent urination through the compatibility of monarch, minister, assistant and guide, the Longjing tea is used as a monarch drug for clearing heat and causing diuresis, the magnolia flower is used as a minister drug for dredging orifices and resolving dampness, and the Taihu Lake Cuiya and the small orchid are used as adjuvant drugs for enhancing diuresis and soothing liver-qi stagnation; the Baoflood tea is a conductant drug for guiding meridians to bladder meridians. The invention also provides a crushing and powder making method and a brewing method of the composition, clinical verification shows that the composition can obviously relieve the symptoms of frequent micturition and urgent micturition, is suitable for preparing health-care food for relieving urinary system discomfort, and is safe and free of side effects.

This invention discloses a traditional Chinese medicine formula for preventing and treating feline urinary tract diseases, its preparation method, and its application. The formula consists of the following components in parts by weight: 15-25 parts of Psoralea corylifolia, 15-25 parts of Alpinia oxyphylla, 10-20 parts of Trigonella foenum-graecum, 5-15 parts of Zea mays, 5-15 parts of Juncus effusus, 10-20 parts of Dioscorea hypoglauca, 10-20 parts of Phellodendron chinense, 10-20 parts of Lonicera japonica, 5-15 parts of Paeonia lactiflora, and 5-15 parts of Glycyrrhiza uralensis. The traditional Chinese medicine formula provided by this invention has diuretic and urinary tract mucosal repairing effects. It can effectively relieve symptoms such as urinary stones, painful urination, hematuria, or gravel in the urine caused by damp-heat in the lower abdomen. It promotes the repair of the urinary tract mucosa in animals with urinary tract diseases, alleviates inflammatory responses, and prevents the formation of crystals in the urine.

A body fluid metering assembly (1), in particular for measuring diuresis, is described, comprising: (i) a body fluid collection container (20) configured to collect a body fluid, such as urine; (ii) a body fluid metering unit (10) comprising a load cell (15) and a coupling mechanism configured to releasably couple the body fluid collection container (20) to the load cell (15), the body fluid metering unit (10) being configured to process sensor data supplied by the load cell (15) and derive a measure of the amount and / or flow rate of the body fluid accumulated in the body fluid collection container (20) as a function of the load applied on the load cell (15); and (iii) a tube (30) attached to an inlet port (20A) of the body fluid collection container (20) and configured to be connected to a source of the body fluid. The body fluid collection container (20) is a substantially rigid container and the coupling mechanism is a spring-loaded interlocking mechanism (50) configured to cooperate with one or more interlocking members (250a, 250b) provided on the body fluid collection container (20) and interlock with the body fluid collection container (20) to form a stable connection between the body fluid metering unit (10) and the body fluid collection container (20).

Aiming at etiology and pathogenesis of chronic diarrhea caused by deficiency-cold in spleen and stomach, the traditional Chinese medicine composition takes hairyvein agrimony, rhizoma acori graminei and rhizoma atractylodis as monarch drugs and takes dried ginger, fructus psoraleae, schisandra chinensis, myristica fragrans, cinnamon, agastache rugosus and Chinese yam as ministerial drugs; according to the traditional Chinese medicine composition, rhizoma corydalis, radix paeoniae alba, scorched hawthorn fruit, pericarpium granati, plantain herb, red halloysite, fructus chebulae and radix saposhnikoviae are taken as adjuvant drugs, liquorice is taken as a conductant drug, all the drugs are compatible, the purposes of invigorating spleen, replenishing qi, eliminating dampness, promoting diuresis, supporting healthy qi and smoothing middle-jiao qi movement can be achieved, the purpose of stopping diarrhea can be achieved, and the chronic diarrhea caused by deficiency-cold in the spleen and the stomach can be effectively treated.

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

The invention relates to the technical field of traditional Chinese medicine compositions and preparations, in particular to a traditional Chinese medicine composition for preventing and treating contrast agent acute kidney injury, a preparation and application. The traditional Chinese medicine composition is prepared from 10 g of radix scutellariae, 15 g of poria peel, 9 g of pericarpium arecae, 9 g of pericarpium citri reticulatae, 9 g of cortex mori, 9 g of ginger peel and 10 g of rhizoma atractylodis macrocephalae. The treatment principle of clearing away heat and toxic materials, dispersing blood stasis, tonifying spleen, clearing damp and promoting diuresis is determined on the basis of contrast agent acute kidney injury caused after contrast agent injection. The traditional Chinese medicine composition has the effects of ascending lucidity and descending turbid, invigorating spleen and replenishing qi, and transporting and transforming water dampness; the effects of clearing away heat and toxic materials, regulating qi-flowing for strengthening spleen and inducing diuresis for The traditional Chinese medicine composition disclosed by the invention is precise and appropriate in compatibility, clear in curative effect and good in patient compliance on contrast agent acute kidney injury which is differentiated as spleen and kidney qi deficiency and blood stasis in traditional Chinese medicine, and the medicine can be stopped after contrast agent radiography is performed for 24 hours; clinical experiments show that the traditional Chinese medicine composition for preventing and treating the contrast agent acute kidney injury is obviously superior to a control group in a traditional Chinese medicine treatment group and has statistical significance (P is less than 0.05).

This present disclosure relates to fluid therapy based on adjusted urine output rate and / or sodium output rate, and associated systems, devices, and methods. Exemplary methods can include receiving a sodium excretion input for the patient; receiving a urine output rate; determining an adjusted urine output rate based on the sodium excretion input and the urine output rate; and providing fluid therapy based on the adjusted urine output rate. By determining the amount and / or rate of the infused diuretic and / or hydration fluid based on a patient's actual sodium excretion levels, embodiments of the present technology can optimize and / or customize all or a subset of a diuretic therapy to an individual patient's physiology.

This invention discloses a method for preparing and applying a Miao medicine wine for treating bruises and sprains, comprising the following steps: S1, taking and mixing *Ligusticum striatum*, safflower, *Acanthopanax senticosus*, *Smilax china*, *Ligusticum chuanxiong*, *Sargentodoxa cuneata*, *Sargentodoxa cuneata*, and sappanwood evenly; S2, soaking the mixed Chinese medicinal materials from step S1 in alcohol to obtain the medicinal wine. This invention has the effects of clearing the meridians and relieving pain, promoting blood circulation and removing blood stasis, and promoting diuresis and reducing swelling. The treatment course is short, the efficacy is good, the cure rate is high, and recurrence is not common, with an effectiveness rate of over 98%. It has great potential for widespread application. Furthermore, the medicine of this invention is simple to manufacture, convenient to use, and has no toxic side effects, and can significantly alleviate patient suffering.

The invention discloses a traditional Chinese medicine composition for treating and preventing cardiovascular and cerebrovascular diseases and postoperative repair and recuperation based on classic famous prescription, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition is prepared by combining a prescription based on coptis and colla corii asini decoction, cassia twig decoction, cinnamomum cassia and aconitum carmichaeli decoction and poria cocos, cinnamomum cassia and aconitum carmichaeli decoction, as well as poria cocos, cinnamomum cassia and aconitum carmichaeli decoction, and poria cocos and aconitum carmichaeli decoction, and poria cocos and aconitum carmichaeli decoction, and poria cocos and aconitum carmichaeli decoction, and poria cocos and aconitum carmichaeli decoction and poria cocos and In the formula, ligusticum wallichii and earthworm promote blood circulation to remove blood stasis, dredge collaterals and dissolve thrombus; hawthorn and lotus leaf are used for dissolving turbidity, lowering lipid and regulating blood fat and cholesterol; the poria cocos and the rhizoma alismatis are used for clearing damp and promoting diuresis. The whole formula has the effects of warming yang, dredging collaterals, nourishing yin and blood, promoting blood circulation to remove blood stasis, dissolving turbidity, reducing lipid, calming the heart, soothing the nerves and the like, can be used for treating cardiovascular and cerebrovascular diseases, conditioning dyslipidemia, preventing atherosclerosis and postoperative repair and nursing at the same time, is wide in application range and high in safety, can be prepared into various oral dosage forms, and has a good application prospect.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition provided by the invention comprises astragalus membranaceus, cinnamon, semen cassiae, lotus leaves, poria cocos, lophatherum gracile, malt, hawthorn, rose, pogostemon cablin, sophora flower, semen torreya and emblic leafflower fruit. The formula takes the effects of tonifying spleen and promoting diuresis, soothing liver and regulating qi, and removing food retention and dissolving turbidity as the core, and has multiple effects of promoting urination and relieving stasis. The traditional Chinese medicine composition provided by the invention can regulate and control abnormal signal pathways of fatty liver and atherosclerosis; the compound has no obvious inhibition effect on a hepatic cell line HepG2 and has an inhibition effect on a hepatic stellate cell line LX2; the obvious lipid-lowering effect is achieved on a HepG2 high-lipid model; liver fat accumulation and liver injury in a TAA-induced zebrafish fatty liver model can be remarkably improved.

The compound preparation is characterized by being prepared from the following components in parts by mass: 11 to 13 parts of cortex acanthopanacis, 9 to 12 parts of herba taxilli, 21 to 23 parts of radix achyranthis bidentatae, 9 to 11 parts of radix paeoniae rubra, 8 to 10 parts of herba lycopi, 20 to 22 parts of radix salviae miltiorrhizae, 11 to 13 parts of semen vaccariae, 5 to 8 parts of spina gleditsiae, 6 to 9 parts of rhizoma chuanxiong, 5 to 7 parts of liquorice root and 20 to 22 parts of radix astragali seu hedysari. The medicines are compatible, are mainly used for tonifying liver and kidney, activating blood and inducing diuresis, are compatible with qi and blood, and are suitable for rheumatic arthralgia and chronic inflammation. Cortex acanthopanacis and herba taxilli expel wind-damp and strengthen muscles and bones, herba lycopi and radix achyranthis bidentatae promote diuresis and descend, and the traditional Chinese medicine is suitable for rheumatism edema and lower limb Radix astragali and radix angelicae sinensis tonify qi and nourish blood, radix salviae miltiorrhizae and rhizoma chuanxiong activate blood and promote qi circulation, and the traditional Chinese medicine is suitable for qi and blood stasis type diseases. The liquorice is used for regulating the medicine property of the whole formula and alleviating the drasticality of the cowherb seeds, the spina gleditsiae and the like, and glycyrrhizic acid contained in the liquorice has an anti-allergic effect and reduces the risk of medicine allergy.

A method and formulations are developed for enhancing solubility and improving the permeability of bumetanide across a mucosal membrane. The formulation includes bumetanide in various water-cosolvent mixtures, which include at least one of an alcohol, polyether, glyceride, pyrrolidone, or any combination thereof. In some embodiments, the formulation has a pH of about 3.5 to about 8.0. In some embodiments, the formulation enhances the solubility and permeability of the bumetanide. Also disclosed is a use of the formulation for rapidly achieving effective bumetanide plasma concentration leading to diuresis. In some embodiments, the formulation can be administered to a subject conveniently without injection in the treatment of edema associated with heart failure or other conditions.

This invention relates to the field of traditional Chinese medicine, specifically to a traditional Chinese medicine composition, its preparation method, and its application. The traditional Chinese medicine composition, by weight, comprises the following components: 2-15 parts of ginger-processed Pinellia ternata, 2-15 parts of stir-fried Atractylodes macrocephala, 15-25 parts of Gastrodia elata, 15-25 parts of Poria cocos, 2-15 parts of dried tangerine peel, 5-15 parts of Polyporus umbellatus, 2-15 parts of cinnamon twig, 5-15 parts of Alisma plantago-aquatica, and 1-8 parts of Panax notoginseng powder. This traditional Chinese medicine composition, by combining various components in a specific ratio, allows the components to synergistically work together to achieve the effects of strengthening the spleen and resolving phlegm, promoting diuresis and eliminating turbidity, and calming the liver and unblocking the meridians. Precise proportions and dosages ensure that the entire formula exerts a synergistic effect in improving metabolism, reducing inflammation, and protecting the kidneys, thereby effectively delaying target organ damage while stabilizing blood pressure.

The present invention provides a traditional Chinese medicine composition for herpes zoster oticus and its application, which relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is obtained by reasonable compatibility in accordance with the principle of syndrome differentiation and treatment of traditional Chinese medicine, and is composed of Scorzonera austriaca, Cimicifuga foetida, Cortex Fraxini, Arisaema heterophyllum, Abutilon theophrasti, Aucklandia lappa, Chrysanthemum indicum, Houttuynia cordata, Cynanchum atratum, and Ginger Peel. The compatibility of various herbs is reasonable, and it has the effects of clearing heat and detoxifying, promoting qi circulation to relieve pain, detumescing and treating sores, and promoting diuresis to reduce swelling. It has good curative effect, short course of treatment, and no toxic and side effects. The traditional Chinese medicine composition of the present invention has a significant improvement effect on the spontaneous pain behavior of rats with postherpetic neuralgia model and aspects such as the levels of serum IL-2, IL-6, and TNF-α, achieving the simultaneous treatment of the symptoms and root causes of herpes zoster oticus. The traditional Chinese medicine composition of the present invention has a significant therapeutic effect on herpes zoster oticus, has a high effective rate, can quickly relieve the clinical symptoms of patients, shorten the recovery time of patients, and relieve the pain of patients.