19results about How to "High cure rate" patented technology

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

The invention relates to the technical field of biological medicines, in particular to application of isorhamnetin in preparation of a medicine for preventing and treating fatty liver diseases related to metabolic dysfunction. The invention provides application of isorhamnetin or pharmaceutically acceptable salts, esters or derivatives thereof in preparation of drugs for preventing and treating fatty liver diseases related to metabolic dysfunction. The invention also provides application of isorhamnetin or pharmaceutically acceptable salts, esters or derivatives thereof in preparation of drugs for preventing and treating diseases caused by intestinal flora disorder. The isorhamnetin can recover the diversity and richness of intestinal flora of mice with fatty liver diseases related to metabolic dysfunction and recover the balance of the intestinal flora, and the high-dose (50 mg / kg.d) donor flora transplantation of the isorhamnetin can partially reproduce metabolism improvement. The fatty liver diseases related to obesity or metabolic dysfunction are relieved through an'intestinal flora-bile acid-lipid metabolism 'axis.

The application discloses a plasma metabolic marker composition and a screening method and application thereof, and relates to the technical field of biomedicine. The plasma metabolic marker composition comprises glycyl-L-glutamic acid, phosphatidylcholine 38:7, pyrrole-2-formic acid and phosphatidylethanolamine 36:2p. The metabolic marker composition is significantly different in different cancer types, can distinguish different cancer types of cancer patients, and realizes the detection of pan-cancer. The metabolic marker composition is non-invasive and minimally invasive when used for the detection of pan-cancer, is more suitable for the screening and detection of a large number of ordinary people, has high sensitivity and specificity, is more suitable for the early screening of cancer, and is helpful for the early screening, early diagnosis and early treatment of cancer, and is helpful for improving the survival rate and cure rate of cancer patients.

The application belongs to the technical field of new materials, and discloses a transdermal drug delivery device and a preparation method and use method thereof. The transdermal drug delivery device comprises a flexible patch and a power supply. The flexible patch comprises a flexible substrate and a liquid metal electrode. The liquid metal electrode is embedded in the flexible substrate, and the flexible patch is modified by extracellular matrix proteins. The power supply is connected with the flexible patch. The use method is as follows: a drug is coated on the surface of skin, the transdermal drug delivery device is covered on the skin surface coated with the drug, the power supply is turned on, and the transdermal drug delivery device realizes the penetration of the drug into the skin through iontophoresis. The device simply connects the flexible patch with the power supply, realizes the miniaturization and portability of iontophoresis therapy, does not harm the skin, is efficient and safe, and has high patient compliance.

The present application belongs to the technical field of pharmaceutical preparation, and discloses a traditional Chinese medicine composition for preventing and treating eperythrozoonosis of animals, which is composed of the following raw medicinal materials in parts by weight: 25-35 parts of Corydalis decumbens, 12-25 parts of Hypericum japonicum, 12-25 parts of Hemerocallis fulva, 10-20 parts of Jatropha curcas leaves, and 8-16 parts of Smilax china. The raw medicinal materials are Chinese medicinal materials or Chinese medicine extracts equivalent to the crude drug amount of the above-mentioned Chinese medicinal materials. The traditional Chinese medicine composition can greatly improve the cure rate of sick pigs and effectively reduce breeding losses. Moreover, the traditional Chinese medicine composition is green, safe, non-toxic, and has no side effects, and has the advantages of prevention and treatment, and good market application value.

The invention relates to the technical field of animal husbandry, and discloses a temperature-sensitive sustained-release gel for treating cow mastitis and a preparation method thereof.The temperature-sensitive sustained-release gel is prepared from, by mass, 15%-24% of a triblock copolymer PLGA-PEG-PLGA solution, 3-7 parts of eucommia ulmoides powder, 2-5 parts of nisin, 1-3 parts of a stabilizer, 1-3 parts of a pH regulator and the balance water. One-time perfusion can be completed under the condition of a small administration volume, a stable sustained-release drug library is formed in the local part of the mammary gland, and the drug is continuously and slowly released through the diffusion effect of the gel layer, so that a lasting inhibition effect is generated on pathogenic bacteria on the surface and in the mammary gland tissue. Due to the fact that the medicine mainly plays a role in the local part of the breast, the high local medicine concentration can be maintained in the breast tissue, diffusion of the medicine to the whole body tissue is reduced, and therefore the risk that the medicine has adverse effects on non-lesion organs or tissues is reduced.

The invention discloses an intelligent high-precision weighing device for dietary therapy food materials of a diabetic with emaciation. The intelligent high-precision weighing device is used for measuring the obesity degree. Calculating daily total energy; heat energy occupied by the three nutrients is calculated, and the heat energy occupied by the three nutrients is calculated according to the heat generation ratio of the three heat generation nutrients in the daily diet of normal adults recommended by the Chinese Nutrition Society; respectively calculating the daily required amounts of the three major nutrients; adjusting the structure and quantity of the whole nutrients; in the first step, the staple food amount is determined; and then each auxiliary food intake is determined. The device can accurately and ingeniously avoid diet taboo, accurately formulate personalized recipes for marsh diabetic patients, open a kitchen diet therapy way of high-precision standardized food material weighing, flexibly adjust food material contents and increase food diversification, so that the compliance of the patients can be greatly improved, and the dietary therapy effect of the patients is improved. The success rate of blood sugar control is greatly increased for a user, the effectiveness of blood sugar stability is maintained, and complications of a patient are prevented after long-term use.

This invention provides the application of N-carbamoylglutamate (NCG) in the prevention and treatment of bovine follicular cysts, along with related models and screening methods. Specifically, it relates to the application of NCG in the preparation of products for the prevention and / or treatment of bovine follicular cysts, and preventive and therapeutic compositions containing NCG. This invention also establishes an in vitro cell model of bovine follicular cysts using 10... ‑7 Treatment of bovine ovarian granulosa cells with M-adrenocorticotropic hormone (ACTH) for 48 hours stably induces a cyst-like state of hormonal imbalance. Based on this model, an in vitro screening method using NCG as a positive control is provided to evaluate the preventive and therapeutic potential of candidate substances. In vivo experiments have confirmed that adding NCG to the diet of dairy cows can effectively treat and prevent follicular cysts. This invention provides a safe and efficient new non-hormonal strategy for the prevention and treatment of bovine follicular cysts, and is accompanied by reliable research and screening tools.

The invention relates to the technical field of medical treatment and public health, and discloses a decoction and a hot compress bag for dredging treatment of a whole-body clogging point, and a corresponding pushing and pressing technology. The decoction is composed of the following raw materials by weight: 40 g of dried ginger slices, 3 g of licorice, 3 g of red dates, 3 g of Chinese wolfberry, 5 g of ginseng, and 2.5 L of water. The hot compress bag comprises a bag body and a traditional Chinese medicine bag placed in the bag body, and the bag body is filled with ores and / or red beans. According to the decoction and the hot compress bag for dredging treatment of the whole body clogging point, the decoction for oral administration and the hot compress bag for external application are combined with corresponding pushing and pressing methods for combined use, various diseases caused by clogging of organs and tissues of a patient can be effectively treated, and three highs (hyperlipidemia, hyperglycemia and hypertension), leukemia, rheumatoid arthritis and lupus erythematosus can be effectively improved and cured; , hyperthyroidism, hypothyroidism, andrology and gynecology diseases. The traditional Chinese medicine composition has the advantages of obvious effect, high cure rate, rapid improvement of immune function of patients, improvement of disease resistance, safety, effectiveness and no toxic or side effect.

The utility model provides a negative pressure suction and local hyperbaric oxygen therapy combined device, which relates to the technical field of medical treatment and comprises a rescue box, a partition plate is fixedly connected inside the rescue box, and the inside of the rescue box is partitioned by the partition plate. The second collecting frame and the negative pressure suction machine body are combined in the rescue box, the problems of wound debridement and oxygen deficit can be solved at the same time, bacteria, toxins and wound necrotic tissue in seawater can be effectively removed for a wound soaked in the seawater and a chronic wound infected by anaerobic bacteria, and the wound debridement and oxygen deficit can be effectively removed for the wound soaked in the seawater and the chronic wound infected by anaerobic bacteria. Compared with a pure NPWT or TOT technology, the negative pressure suction machine has the advantages that the cure rate is greatly increased, the healing time is shortened, certain portability can be achieved due to the fact that the second collecting frame and the negative pressure suction machine body are combined in the rescue box, and when a user uses the negative pressure suction machine, the negative pressure suction machine can be conveniently used by the user. And the device can be quickly moved.

The application discloses a Mongolian medicine characteristic enema for treating ulcerative colitis and relates to the technical field of biological medicine. The enema is prepared from a Mongolian medicine composition. The Mongolian medicine composition comprises the following components in parts by weight: Punica granatum 25-35 parts, Cinnamomum cassia 15-25 parts, cold water stone 15-25 parts, Amomum villosum 15-25 parts, Forsythia suspense 15-25 parts, Curcuma longa 15-25 parts, Terminalia chebula 15-25 parts, dried ginger 15-25 parts, Calvatia 15-25 parts, Caulis Sargentodoxae 15-25 parts, Radix Glycyrrhizae 5-15 parts, Platycladus orientalis 5-15 parts, Amomum kravanh 5-15 parts, alkali 5-15 parts and Polygonatum 5-15 parts. The Mongolian medicine characteristic enema has the advantages of improving the local effect of the medicine, reducing adverse reactions, having clear clinical curative effect and being innovative in the Mongolian medicine characteristics, and can provide a safe, effective and economical treatment scheme for UC patients.

The present invention discloses a lamprey serum globular lectin, a preparation method thereof and its application in the detection of liver cancer, belonging to the technical field of cancer detection. The present invention discovers that glycosylation modification is abnormally highly expressed in liver cancer patients. The lamprey serum globular lectin is isolated and purified from lamprey serum. The lamprey serum globular lectin can specifically bind to glycan structures such as Galβ1-3GlcNAc, GlcNAcβ1-2Man and Manα1-2Man of glycoproteins in liver cancer tissues, and can be used for the diagnosis of liver cancer. The lamprey serum globular lectin of the present invention can diagnose liver cancer efficiently and specifically, is particularly sensitive to the diagnosis of intrahepatic cholangiocarcinoma, has high reference value for the diagnosis of liver cancer, and is suitable for popularization and application.

This invention discloses pharmaceutical compositions containing endogenous STING agonists, and the use of these compositions in the preparation of medicaments for treating and / or repairing ischemic stroke brain injury; it also discloses the use of exogenous STING agonists, or compositions thereof with magnesium salts, or compositions thereof with stroke-treating pharmaceutical compositions in the preparation of medicaments for treating and / or repairing ischemic stroke brain injury. The pharmaceutical compositions containing STING agonists of this invention significantly improve efficacy in treating ischemic stroke and / or repairing brain injury, not only significantly alleviating the difficulty of a narrow emergency window, but also improving cerebral blood circulation and neuroprotection, and exhibiting significant brain function repair effects during subsequent rehabilitation.

The application discloses a nystatin solution and a preparation method and application thereof, which is prepared from the following raw materials in parts by weight: nystatin 20-50 parts, dimethyl sulfoxide 110-220 parts, preservative 1.5-2.0 parts, antioxidant 0.5-1 part and 1,2-propylene glycol 737-880 parts. The application creatively adopts a composite solvent system of dimethyl sulfoxide and propylene glycol, utilizes the extremely strong dissolving capacity of dimethyl sulfoxide and the auxiliary solubilization and dilution effect of propylene glycol, and produces a significant synergistic effect. The system can completely dissolve up to 50 parts by weight of nystatin, forms a clear, transparent and uniform stable solution, fundamentally solves the technical bottleneck that nystatin cannot be prepared into a high-content solution due to poor water solubility, and lays a foundation for poultry group water medication.

The application provides an N-terminal fatty acid modified antibacterial peptide analogue and application thereof. Specifically, the antibacterial peptide analogue of the application has a fatty acid (dodecanoic acid, tetradecanoic acid or octadecanoic acid) modification at the N terminus of a super short peptide Lys-Gly-Lys to form a lipopeptide substance. The N-terminal fatty acid modified antibacterial peptide analogue described in the application can inhibit a plurality of pathogenic bacteria, in particular a plurality of mastitis pathogenic bacteria, has high inhibitory activity, and has a unique antibacterial mechanism, is not easy to induce drug resistance of pathogenic bacteria, can more safely inhibit bacteria, and can also solve the problem of antibiotic resistance easily produced in the treatment process of mastitis; further, the antibacterial peptide analogue of the application can also down-regulate the expression of body pro-inflammatory factors (for example, TNF-alpha, IL-6), and accelerate the repair of infected site tissues. The antibacterial peptide analogue of the application can effectively improve the cure rate of dairy cows and reduce economic losses.

The invention discloses a traditional Chinese medicine composition for treating skin diseases and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicines. The composition comprises tripterygium wilfordii, fructus kochiae, angelica sinensis, radix angelicae, frankincense, myrrh, periostracum cicada, pearl and menthol. The external emulsifiable paste with the traditional Chinese medicine composition is prepared by decocting medicinal oil, preparing powdery medicine and preparing water extraction medicine. The composition disclosed by the invention has a good curative effect on eczema, urticaria, skin itch and the like. The traditional Chinese medicine has the effects of dispelling wind, nourishing blood, promoting blood circulation to remove blood stasis, moistening dryness and relieving itching.

The invention discloses a neutralizing monoclonal antibody for resisting feline panleucopenia virus and application of the neutralizing monoclonal antibody, and belongs to the technical field of bioengineering. The antibody comprises a heavy chain variable region (VH) and a light chain variable region (VL), and amino acid sequences of the heavy chain variable region (VH) and the light chain variable region (VL) are respectively shown as SEQ ID NO: 1 and SEQ ID NO: 2; the antibody is an IgG2a subtype and kappa light chain, can specifically bind to FPV VP2 protein, and effectively neutralizes infection of an F81 cell by an FPV-ZZ20230 strain under the dilution ratio of 1: 64. The invention also provides nucleic acid molecules (SEQ ID NO: 8-9) for coding the antibody, an expression vector, a host cell and a preparation method. The antibody can be used for preparing medicines for preventing or treating feline panleucopenia, and can also be used as a detection antibody for ELISA (enzyme-linked immuno sorbent assay), Western blot or indirect immunofluorescence (IFA) diagnostic kits. The antibody is clear in structure and high in neutralizing activity, does not need to be preserved by hybridoma, and has good clinical application and industrialization prospects.

This invention discloses the application of reagents for detecting REEP protein in the preparation of products for diagnosing prostate cancer, relating to the field of biomedical technology. Through proteomic analysis, ELISA assays, and immunohistochemical analysis of urinary proteins from prostate cancer patients, clear cell renal cell carcinoma patients, urothelial carcinoma patients, and healthy individuals, as well as paraffin-embedded tissue samples from prostate cancer patients and surrounding normal prostate tissue, urothelial carcinoma tissue, and clear cell renal cell carcinoma tissue, it was found that REEP6 and REEP5 proteins are related to the occurrence and development of prostate cancer and can be used to assist in the diagnosis of prostate cancer. Furthermore, in urinary testing, REEP6 and REEP5 have higher sensitivity compared to PSA, and the three proteins can complement each other, thus helping to improve the diagnostic rate and non-invasive screening capabilities. Research on the relationship between REEP6 and REEP5 proteins and prostate cancer facilitates non-invasive follow-up after treatment and guides medication, thereby improving survival rates.