110results about How to "High cure rate" patented technology

The utility model discloses a bone needle clamping block, which belongs to the field of medical instruments and is provided with a needle clamping seat, the needle clamping seat is provided with a first ball socket, a rotating needle clamp is arranged in the first ball socket, the rotating needle clamp is provided with a hemispherical lower clamping block, an upper clamping block and a pressing plate, a needle clamping groove is arranged between the upper clamping block and the lower clamping block and used for clamping bone needles, and the pressing plate is arranged on the upper clamping block. And the locking bolt A locks and fixes the rotating needle clamp, the needle clamp seat and the bone needle clamped by the rotating needle clamp seat. A sliding groove is further formed in the needle clamp seat, a sliding block is arranged in the sliding groove, a second ball socket is arranged on the upper surface of the sliding block, a through hole is formed in the sliding block below the second ball socket, the rotating needle clamp is also arranged in the second ball socket, a long-strip-shaped hole is formed in the needle clamp seat below the sliding groove, and a locking nut is arranged at the lower end of the long-strip-shaped hole. And the locking bolt B sequentially penetrates through the second needle clamp, the sliding block and the needle clamp seat and is matched with the locking nut to lock and fix the second needle clamp and the bone needle clamped by the second needle clamp.

The invention discloses a traditional Chinese medicine composition for treating lumbago, and relates to the field of traditional Chinese medicines, and the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: rhizoma drynariae, teasel root, eucommia ulmoides, caulis spatholobi, dragon's blood, catechu, frankincense, myrrh, safflower, ground beetle, native copper and radix aconiti preparata. The traditional Chinese medicine composition is free of side effects, remarkable in effect and high in cure rate, a patient lies on the bed in a prostrate mode, a physician conducts hot compress for 3-5 min with a clean hot towel and then conducts wet hot compress with medicine liquid, the temperature of the medicine liquid is controlled to be 50-60 DEG C, and 25-35 min is conducted every time. A doctor puts sterile gauze into the hot liquid medicine to be completely soaked, clamps the two ends of the gauze with haemostatic forceps or tweezers, twists the gauze until no water drops, applies the gauze to the lumbago position, replaces the gauze every 3-5 minutes, and wraps the gauze with a plastic film to keep the temperature and humidity. The curative effect is observed as follows: the lumbago symptom is improved after hot compress treatment for 7 days. The treatment is carried out for 7 days after the second diagnosis, the treatment is carried out twice every 8 hours every day, and each time lasts for 30 minutes. And lumbago does not occur in the third diagnosis.

The invention belongs to the technical field of biology, and particularly relates to a small molecule peptide composition and method for regulating natural calculus bovis production. The small molecule peptide aiming at a key target spot is designed by deeply researching secretion and metabolism of ox bile. The action mechanism covers biliary secretion stimulation, component optimization, bezoar key enzyme activity promotion and immune response regulation. A chemical synthesis or biotechnology means is adopted for preparation, and the dosage is determined according to cattle conditions during application. The safety is strictly evaluated, the yield of the natural calculus bovis can be obviously improved by 65%, the quality is also greatly improved, the effective components are increased, the impurities are reduced, the drug effect is enhanced, a new efficient and safe way is opened up for the production of the natural calculus bovis, and the method has a wide application prospect.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The invention discloses muscle and bone pain ointment and a preparation method thereof, and belongs to the field of traditional Chinese medicine, and the muscle and bone pain ointment is prepared from the following components in parts by mass: 80-120 parts of circium japonicum, 80-120 parts of serrate rabdosia herb, 80-120 parts of Chinese starjasmine stem, 80-120 parts of elsholtzia, 80-120 parts of radix curcumae, 80-120 parts of herba aristolochiae, 80-120 parts of piper wallichii, 80-120 parts of caulis sinomenii, 80-120 parts of honeysuckle stem, 80-120 parts of ferula asafetida, 80-120 parts of acalypha australis, 80-120 parts of euphorbia helioscopia, 400-600 parts of sesame oil and 1000-2000 parts of rosin. The traditional Chinese medicine is safe, effective and high in cure rate. The traditional Chinese medicine can be widely applied to various bone fracture and bone diseases, cervical and lumbar disc herniation, and muscle and bone pain caused by wind, cold and dampness.

The invention discloses a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in northern cold regions, and belongs to the technical field of traditional Chinese veterinary medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 16-24 parts of cassia twig, 16-24 parts of raw radix paeoniae alba, 8-12 parts of honeysuckle, 8-12 parts of dandelion, 8-12 parts of burdock, 8-12 parts of divaricate saposhnikovia root, 3-7 parts of honey and 3-7 parts of liquorice. The traditional Chinese veterinary medicine composition prepared in the embodiment 1 is used for feeding newborn calves to prevent respiratory diseases, and the morbidity can be reduced by 40%. When the traditional Chinese veterinary medicine composition is used for treating respiratory diseases of newborn calves, compared with a treatment group independently using ceftiofur sodium, the cure rate is improved by 13.6%, and the cure time is shortened by 36.24 h.

The present invention provides a pharmaceutical composition for preventing and treating avian white crown disease, belonging to the technical field of chicken breeding. The pharmaceutical composition of the present invention is prepared by mixing 10 to 30 parts of Morin hydrate, 5 to 20 parts of artemisinic acid, 5 to 20 parts of quinic acid, and 5 to 20 parts of ginsenoside total saponin sulfate derivatives. It can effectively improve the phenomena of a sharp drop in egg production rate, an increase in soft-shell eggs, and an increase in mortality rate of sick laying hens in cages, so that the egg production rate, egg quality, and lean meat content can be restored to normal levels; enhance the disease resistance of poultry, reduce stress reactions caused by factors such as drastic changes in temperature and microbial invasion, and improve the immunity of animal bodies; the dosage is small and the curative effect is significant. The high-dose oral liquid of the pharmaceutical composition prepared by the present application was used to feed sick chickens, and the effective rate of treatment reached 100%, and the cure rate reached 94.00%.

The invention belongs to the field of veterinary traditional Chinese medicines, and provides a traditional Chinese medicine composition for enhancing immunity and treating chicken virus infection and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 18 to 22 parts of radix isatidis, 18 to 22 parts of indigo naturalis, 15 to 20 parts of radix angelicae sinensis, 10 to 15 parts of poria cocos, 10 to 15 parts of rhizoma alismatis, 8 to 12 parts of medicated leaven, 8 to 12 parts of radix salviae miltiorrhizae, 8 to 12 parts of radix codonopsis, 8 to 12 parts of rhizoma cyperi and 4 to 8 parts of liquorice root. The traditional Chinese medicine composition disclosed by the invention has outstanding performance in the aspect of improving IgG and IgM levels, and further shows that the traditional Chinese medicine composition disclosed by the invention can effectively stimulate immune response of an organism and enhance the resistance of the organism to viruses. Animal pharmacological experiments show that the compound has a remarkable treatment effect on chicken infectious disease anemia, avian leukosis and chicken adenovirus infection, provides a new treatment thought for treatment of chicken viral infection, and has a wide application prospect.

The invention discloses a traditional Chinese medicine tea substitute drink for treating mild hypertension, which is prepared by the following steps: selecting chrysanthemum, sophora flower, dendrobe, lotus leaf and lophatherum gracile as raw materials, cleaning the raw materials, putting the raw materials into a water cup, boiling drinking water, and pouring the boiled drinking water into the cup; and screwing the cup cover, soaking the raw materials for 10 minutes, and slowly drinking when the water temperature is proper. The traditional Chinese medicine substitutes for tea, and is reasonable in medicine compatibility, unique in curative effect, high in cure rate and direct and rapid in efficacy. The effects of nourishing liver and kidney, stabilizing liver yang, clearing liver and improving eyesight are achieved. The conflict caused by long-term taking of western medicines by the patient is avoided.

The invention relates to a traditional Chinese medicine preparation for treating infectious bursal disease as well as a preparation method and application of the traditional Chinese medicine preparation. The medicament is prepared from the following raw material components: 45 to 50 parts of radix astragali, 30 to 45 parts of radix rehmanniae, 25 to 30 parts of radix isatidis, 25 to 30 parts of folium isatidis, 10 to 45 parts of gypsum, 10 to 20 parts of honeysuckle flower, 10 to 30 parts of fructus forsythiae, 10 to 20 parts of herba taraxaci, 15 to 20 parts of rhizoma atractylodis macrocephalae, 15 to 30 parts of radix paeoniae rubra, 15 parts of bulbus lilii, 15 parts of rhizoma anemarrhenae and 10 to 30 parts of liquorice root. The medicament is prepared by extraction and concentration processes, and can effectively treat the chicken infectious bursal disease caused by the traditional infectious bursal disease virus (IBDV) and the novel variable infectious bursal disease virus (nvvIBDV). The medicine can significantly improve the cure rate of traditional and variant strains, and especially has significant advantages in the treatment of variant strains.

The invention discloses a medicine for treating hyperplasia bone diseases and a preparation method, and belongs to the field of medicine.The medicine comprises curcuma zedoary, stephania tetrandra, ramulus mori, pangolin, fructus hippophae and pure grain vinegar, and the preparation method comprises the steps that the curcuma zedoary, the stephania tetrandra, the ramulus mori and the pangolin are mixed, the fructus hippophae is wrapped with gauze and then put into a sand pottery pot together with the mixed traditional Chinese medicine, cold water is added for soaking, and the medicine is prepared. Boiling with strong fire, decocting with slow fire for 30 minutes, taking out the liquid medicine, adding water again, boiling with medium fire, boiling with slow fire for 30 minutes, taking out the liquid medicine, adding water again, boiling with medium fire, taking out the liquid medicine, discarding the dregs after the liquid medicine is dried, mixing the three times of liquid medicine, putting into a sand pottery pot, heating and concentrating to 2000ml, stopping fire, standing and precipitating, taking clear liquid, and distilling until the stock solution is completely evaporated; the traditional Chinese medicine composition is reasonable in formula, suitable for the physique of all people, free of any side effect and capable of treating internal diseases by external treatment and treating special diseases by special medicines, the cure rate reaches up to 100%, and the traditional Chinese medicine composition is not applicable to the prior art.

The invention discloses a miRNA (micro Ribonucleic Acid) combination for screening lung cancer and a kit of the miRNA combination. The miRNA combination comprises hsa-miR-628-3p, hsa-miR-605, hsa-miR-1204, hsa-miR-4443, hsa-miR-940, hsa-miR-4728-3p, hsa-miR-296-5p, hsa-miR-3130-5p and hsa-miR-216b-5p, and is characterized in that the miRNA combination is prepared from the following raw materials in parts by weight: 20-30% of miRNA, 20-30% of miRNA, 20-30% of miRNA, 20-30% of miRNA and 20-30% of miRNA. The kit further comprises a reverse transcription reaction solution, an amplification detection solution, a nucleic acid extraction reagent, a washing solution, an eluent, a buffer solution, a positive control, a negative control and a blank control. The product is small and exquisite in design and convenient to carry, detection can be completed only by obtaining a blood sample from veins of a patient, and the screening accuracy can be effectively improved while the cost of the patient is reduced by screening lung cancer through blood miRNA. And omission and reduction of quality are avoided.

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

The present invention discloses the application of T cells as biomarkers in the preparation of products for monitoring or predicting the efficacy of anti-HBV treatment, wherein the T cells include Treg cells, CD4+T cells, and CD8+T cells; and also discloses the application of T cells as biomarkers in the preparation of products for predicting the risk of relapse after achieving clinical functional cure in anti-HBV treatment, wherein the T cells include CD8+ subgroup CXCR5+CD8+T cells and CD4+ subgroup CXCR5+CD4+T cells. The present invention can be applied to guide interferon antiviral treatment of chronic hepatitis B, provide new immune targets for exploring antiviral treatment of chronic hepatitis B, improve cure rate, and reduce relapse rate.

The invention belongs to the technical field of Chinese medicine preparation, and specifically is a preparation method and application of a Chinese medicine preparation for treating hypertension complicating pregnancy. The method comprises the following steps: washing and drying Chinese medicinal materials in a prescribed amount, crushing them respectively, and mixing them uniformly to obtain a mixed powder A; soaking the remaining components in water according to the prescribed amount, decocting, filtering, and concentrating to obtain a Chinese medicine extract with a relative density; putting the obtained extract into a vacuum dryer for fluidized drying, and crushing them to obtain a mixed powder B after combined operation; and mixing the mixed powder A and the mixed powder B uniformly and sealing them for storage to obtain a finished product, so as to give full play to the efficacy of each medicine and avoid the loss of efficacy, so as to achieve a high release rate of the effective ingredients of the medicine, and significantly improve the stability and solubility of the medicine, thereby improving the therapeutic effect and cure rate of the medicine.

The invention belongs to the technical field of biomedicine, particularly discloses a periprosthetic infection treatment target and application thereof, and particularly discloses application of an antagonist or an expression inhibitor aiming at Treg cell immune checkpoint molecules CXCR6 in any one of the following aspects: preparing a product for preventing, treating, relieving or improving periprosthetic infection; preparing a product for inhibiting occurrence and development of periprosthetic infection; preparing a product for inhibiting proliferation and / or growth of periprosthetic infected tissue cells; preparing a product for promoting or inducing apoptosis of periprosthetic infected tissue cells; preparing a product for inhibiting inflammation, necrosis or fibrosis of periprosthetic infected tissues; according to the invention, a target CXCR6 knockout experiment is carried out on Treg, and a CXCR6-targeted product is found to have a potential therapeutic effect on reduction of PJI-related bacterial colonization and biofilm formation.

The present invention provides an additive composition and its application, wherein the additive composition comprises 10-15 parts of Chinese herbal medicine, 3-5 parts of norfloxacin, and 1.5-3 parts of vitamin powder by weight, and the Chinese herbal medicine formula is as follows: roasted astragalus, codonopsis, atractylodes, angelica, tangerine peel, roasted licorice, cimicifuga, bupleurum, jujube, tuckahoe, orientalis, coptis root, rhubarb, and the mass ratio is 3:2:2:2:2:1.5:1:1:1:1:1:1:1:1. The additive composition provided by the present invention can be effectively used for the prevention and treatment of Chinese sturgeon gill swelling disease, and plays an important role in protecting the Chinese sturgeon species.

The invention relates to the technical field of biological medicines, in particular to application of isorhamnetin in preparation of a medicine for preventing and treating fatty liver diseases related to metabolic dysfunction. The invention provides application of isorhamnetin or pharmaceutically acceptable salts, esters or derivatives thereof in preparation of drugs for preventing and treating fatty liver diseases related to metabolic dysfunction. The invention also provides application of isorhamnetin or pharmaceutically acceptable salts, esters or derivatives thereof in preparation of drugs for preventing and treating diseases caused by intestinal flora disorder. The isorhamnetin can recover the diversity and richness of intestinal flora of mice with fatty liver diseases related to metabolic dysfunction and recover the balance of the intestinal flora, and the high-dose (50 mg / kg.d) donor flora transplantation of the isorhamnetin can partially reproduce metabolism improvement. The fatty liver diseases related to obesity or metabolic dysfunction are relieved through an'intestinal flora-bile acid-lipid metabolism 'axis.

The present invention provides a Chinese medicine composition for preventing and treating piglet diarrhea and a preparation method thereof, and relates to the technical field of veterinary medicine. The Chinese medicine composition is composed of a certain proportion of Rheum officinale, palm seeds, knotweed, Euryale ferox, and Scutellaria liao. The Chinese medicine composition of the present invention has a good therapeutic effect on piglet diarrhea caused by indigestion, bacteria, viruses, and poor pig house breeding environment. The Chinese medicine composition of the present invention is applied to piglet breeding, has the effects of astringing the intestines and stopping diarrhea, clearing away heat and removing dampness, strengthening the spleen and kidneys, and promoting digestion and strengthening the stomach, and can also enhance the immunity of piglets. The present invention belongs to a pure natural Chinese medicine preparation, which has the advantages of safe use, high cure rate, no drug resistance, safety and no residue, no toxic side effects, etc., and has broad application prospects.

The application discloses a plasma metabolic marker composition and a screening method and application thereof, and relates to the technical field of biomedicine. The plasma metabolic marker composition comprises glycyl-L-glutamic acid, phosphatidylcholine 38:7, pyrrole-2-formic acid and phosphatidylethanolamine 36:2p. The metabolic marker composition is significantly different in different cancer types, can distinguish different cancer types of cancer patients, and realizes the detection of pan-cancer. The metabolic marker composition is non-invasive and minimally invasive when used for the detection of pan-cancer, is more suitable for the screening and detection of a large number of ordinary people, has high sensitivity and specificity, is more suitable for the early screening of cancer, and is helpful for the early screening, early diagnosis and early treatment of cancer, and is helpful for improving the survival rate and cure rate of cancer patients.

The present invention discloses a physical targeted hyperthermia system for tumor treatment and a control method thereof, which relate to the technical field of medical equipment. The system mainly comprises a hyperthermia apparatus body, a microwave radiating device, a microwave receiving device, a microwave imaging unit, a microwave temperature measuring unit, a hyperthermia scheme generating unit, a hyperthermia scheme executing unit and a hyperthermia control device. The hyperthermia apparatus body is used to provide a stable support surface for a human body and related functional devices, the microwave radiating device is used to radiate microwaves of set wavelength and frequency in a set direction, the microwave receiving device and the microwave imaging device are used to accurately locate the position of tumor tissue, the hyperthermia scheme generating unit is used to generate hyperthermia parameter information, the hyperthermia scheme executing unit generates corresponding hyperthermia scheme execution information based on the hyperthermia parameter information, the control device controls the microwave radiating device based on the execution information, and utilizes microwave focusing to heat the tumor tissue to accurately kill the tumor tissue of the human body.

The invention provides a preparation method of Bistort and Green Tiger Granules for blue ear disease in pigs, and the preparation method comprises the following steps: S1, taking dried Bistort, Terminalia chebula, Polygonum cuspidatum, Folium Isatidis, Folium Chrysanthemi, and Folium Eucommia for crushing to obtain a mixed crushed material; S2, placing the mixed crushed material in an ethanol / water mixed solution, ultrasonic extraction, ultrahigh pressure extraction; filtering to obtain a filtrate 1 and a filter residue 1; the filtrate 1 is decompressed and concentrated to obtain a concentrated solution 1; S3, placing the filter residue 1 in water, ultrahigh pressure extraction; filtering to obtain a filtrate 2 and a filter residue 2; the filtrate 2 is decompressed and concentrated to obtain a concentrated solution 2; S4, adding ethanol to the filter residue 2 and then adding ethyl acetate, ultrahigh pressure extraction; filtering to obtain a filtrate 3; the filtrate 3 is decompressed and concentrated, dried to obtain an extract; S5, mixing the concentrate 1 and the concentrate 2, adding the extract and auxiliary materials, mixing evenly, and granulating. The Bistort and Green Tiger Granules prepared by the invention can effectively treat blue ear disease, with a high overall cure rate and good safety.

The invention discloses a medicine for preventing and treating infectious bronchitis in chickens and a preparation method thereof, and belongs to the field of medical technology. The raw materials for preparing the medicine include, by weight: 6-35 parts of ephedra, 10-30 parts of platycodon, 15-40 parts of phragmites, 5-30 parts of bitter almonds, 6-60 parts of licorice, 12-25 parts of plantain, 5-30 parts of fructus aurantii, 75-200 parts of gypsum, 1-18 parts of stemonae and 2-30 parts of mint. The preparation method includes the steps of crushing medicinal materials, enzymatic extraction, decoction, filtration, concentration and fine filtration. The experimental results show that the medicine of the present invention has a significant therapeutic effect, can effectively improve the cure rate of sick chickens, reduce the viral load in the body, and significantly improve the egg production and egg quality of sick laying hens. The composition also shows good safety and no obvious adverse reactions. Therefore, the present invention provides a new option for the prevention and treatment of infectious bronchitis in chickens, and has important application value.

The invention discloses a medicine component for treating burns and scalds and a preparation method thereof, the medicine component for treating burns and scalds comprises medicine powder and medicinal liquor, the medicine powder comprises the following traditional Chinese medicines in parts by weight: 1 part of ox horn, 5 parts of astragalus membranaceus, 3 parts of angelica sinensis, 3 parts of sargentgloryvine stem, 2 parts of safflower carthamus, 3 parts of dried alum, 0.5 part of dragon's blood, 2 parts of rhizoma cimicifugae and 3 parts of corydalis tuber; the medicinal liquor is prepared from the following traditional Chinese medicines in parts by weight: 5 parts of rhizoma polygoni cuspidati, 5 parts of radix et rhizoma rhei, 5 parts of radix scutellariae, 3 parts of rhizoma coptidis, 3 parts of cortex phellodendri, 5 parts of rhizoma bletillae, 5 parts of fructus gardeniae, 5 parts of fructus forsythiae and 1 part of borneol. By adopting the combination of the medicinal powder and the medicinal liquor, the invention provides the medicine component for treating burns and scalds and the preparation method thereof, the medicine component for treating burns and scalds and the preparation method thereof can effectively treat burns and scalds and effectively solve the phenomenon of infection of wound surfaces of burns and scalds in the prior art, and the medicine component is high in cure rate, free of toxic and side effects, good in treatment effect and free of scars.

The present invention belongs to the field of bioinformatics, and specifically relates to a method and system for predicting the risk of tumor cell metastasis. The method of the present invention predicts the S of the tumor cell to be detected based on the gene expression information of the tumor cell to be detected. EMT , S Tra and S comm ; Among them, S EMT Used to indicate the epithelial-mesenchymal transition ability of tumor cells, S Travel Indicates the survival ability of tumor cells in blood circulation, S comm Indicates the ability of tumor cells to invade tissues or organs; then calculate the risk factor S of the tumor cells to be tested for metastasis Merta The method of the present invention can assist doctors in timely diagnosis and targeted treatment of cancer patients in the early stage of cancer metastasis, and can guide the research and development of new anti-cancer drugs, which is conducive to improving the prevention and treatment rate and cure rate of cancer.

This invention discloses a modified Dingtong Decoction granule, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The granule is made from cinnamon twig, white peony root, prepared licorice root, dried ginger, jujube, Sichuan pepper, dried plum, Quisqualis indica root bark, roasted hawthorn fruit, roasted malt, roasted barley sprout, fragrant rice sprout, maltose, astragalus root, angelica root, vinegar-processed corydalis rhizome, stir-fried atractylodes macrocephala rhizome, and poria cocos. This invention employs a two-factor optimized preparation process of 95℃ constant-temperature micro-boiling extraction + 45% ethanol directional alcohol precipitation. After screening and verification at three temperature levels (80℃, 95℃, and 100℃), the extraction rates of effective components such as paeoniflorin, cinnamaldehyde, and corydaline are increased by more than 18% compared to traditional decoctions. Among these, the retention rate of cinnamaldehyde is increased by more than 30% compared to boiling extraction, and the toxicity of components such as azadirachtin is reduced by more than 42%. The granule formulation of this invention achieves a cure rate of 76.7% for recurrent abdominal pain of the deficiency-cold type in children, with a recurrence rate of less than 9% after 6 months, an increased pain relief speed of 38%, good patient compliance, and high safety, demonstrating significant clinical application value.

The invention provides a traditional Chinese medicine composition for treating blood-deficiency and wind-movement type meliger syndrome, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from twelve traditional Chinese medicines including bear gall powder, lucid ganoderma, Chinese dates, cicada slough, ligusticum, cornu cervi pantotrichum, morinda officinalis, herba epimedii, human placenta, lily, fructus lycii and caulis spatholobi. The traditional Chinese medicine composition takes blood nourishing, nerve calming, wind dispelling and convulsion relieving as main treatment principles, has the effects of clearing away heat and toxic materials, clearing liver and improving eyesight, tonifying middle-Jiao and Qi, relieving pain and relieving convulsion, can obviously relieve clinical symptoms such as double-eyelid spasm, eyelid skin vibration and jumping, eye soreness, eyelid weakness and lusterless complexion of blood-deficiency wind-movement type meiger syndrome patients, and is high in cure rate, good in safety and free of toxic and side effects. The recurrence cannot easily occur.

The application belongs to the technical field of new materials, and discloses a transdermal drug delivery device and a preparation method and use method thereof. The transdermal drug delivery device comprises a flexible patch and a power supply. The flexible patch comprises a flexible substrate and a liquid metal electrode. The liquid metal electrode is embedded in the flexible substrate, and the flexible patch is modified by extracellular matrix proteins. The power supply is connected with the flexible patch. The use method is as follows: a drug is coated on the surface of skin, the transdermal drug delivery device is covered on the skin surface coated with the drug, the power supply is turned on, and the transdermal drug delivery device realizes the penetration of the drug into the skin through iontophoresis. The device simply connects the flexible patch with the power supply, realizes the miniaturization and portability of iontophoresis therapy, does not harm the skin, is efficient and safe, and has high patient compliance.

The invention discloses a Fopitasvir-containing triple compound preparation for treating hepatitis C and a preparation method of the Fopitasvir-containing triple compound preparation, the compound preparation is a tablet prepared from Sofosbuvir, Amphihevir, Fopitasvir, lactose, microcrystalline cellulose, croscarmellose sodium, povidone and magnesium stearate, and the mass ratio of Sofosbuvir to Amphihevir to Fopitasvir is (6-7): (1-0.5): (2-2.6). The preparation can effectively solve the problems of great side effect and poor treatment effect of the existing preparation.

The invention relates to a dampness-clearing and cold-dispelling black paste and a preparation method thereof. The traditional Chinese medicine preparation is prepared from chaulmoogra, fructus aurantii, pericarpium citri reticulatae viride, polygonum multiflorum, rhizoma alismatis, red halloysite, radix peucedani, teasel root, notopterygium root, golden cypress, gastrodia elata, schizonepeta, peach kernel, thunberg fritillary bulb, mint, radix angelicae pubescentis, cocklebur fruit, cassia bark, Chinese torreya, fennel, pericarpium citri reticulatae, cortex acanthopanacis, oriental wormwood, raw rhizoma cyperi, costus root, asarum, divaricate saposhnikovia root, fructus broussonetiae, polyporus umbellatus, liquorice, semen cuscutae, radix sophorae flavescentis, centipede, rhizoma atractylodis, honeysuckle, garden burnet, rhizoma anemarrhenae, prepared rehmannia root, radix ampelopsis, red The traditional Chinese medicine is prepared from multiple Chinese herbal medicines such as radix rehmanniae recen, eucommia ulmoides, caulis sinomenii, polygala tenuifolia, anise, rhizoma atractylodis macrocephalae, pinellia ternate, fructus cnidii and fructus forsythiae. The elasticity of the black paste is increased, the viscosity is reduced, the black paste can be adhered immediately after being pasted and removed immediately after being uncovered, the black paste does not go mouldy when being wetted and does not become hard after being placed for a long time, the surface is brighter and smoother, the allergy rate is also greatly reduced, the transdermal absorption is enhanced, and the curative effect is also greatly improved. The embodiment of the invention also provides a preparation method of the black paste.