229 results about "Cancellous bone" patented technology

The invention relates to the technical field of medical instruments, and discloses an additive manufacturing bionic bone trabecula full-porous interbody fusion cage which is applied to spinal fusion surgery and is of a bionic bone trabecula full-porous structure made of medical metal through a laser melting or electron beam melting additive manufacturing technology. The interbody fusion cage comprises a front end face, a rear end face, a first side surface, a second side surface, an upper fusion face and a lower fusion face, the upper fusion face and the lower fusion face make direct contact with a vertebral body end plate of a spine, anti-skid teeth are arranged on the surfaces of the upper fusion face and the lower fusion face, and a bone grafting window penetrating through the upper fusion face and the lower fusion face is formed in the center of the interbody fusion cage. The interbody fusion cage has the structure and mechanical property similar to those of cancellous bone and trabecular bone of a human body, can improve the bone combination area and bone ingrowth space, has excellent initial and long-term stability, and can effectively reduce stress shielding so as to improve the bone fusion capability.

The invention discloses a tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data, and belongs to the field of artificial intelligence and computer-aided biomedical engineering. The method comprises a CBCT intelligent segmentation module, an intraoral scanning intelligent segmentation module, an internal tissue segmentation module, a point cloud generation registration module and a parameterized bionic reconstruction module. The point cloud generation registration module further comprises a point cloud generation sub-module and a point cloud registration sub-module; the parameterized bionic reconstruction module further comprises a dentin reconstruction sub-module, a cancellous bone reconstruction sub-module and a gingival reconstruction sub-module. The invention aims to realize tooth semantic segmentation, point cloud reconstruction and parameterized bionic modeling of an organization structure under cross-modal data fusion, and provides high-precision bionic internal structure information for teeth in combination with an artificial intelligence model and parameterized modeling.

A method of implanting a shoulder prosthesis assembly is provided where the method includes advancing by rotation a base member, that includes a cylindrical member and a helical structure, into a resection face of a humerus of a patient such that the helical structure is submerged in and engages cancellous bone of and does not extend distally of an epiphysis of the humerus, the cylindrical member being accessible at the resection face of the humerus when the base member is so advanced; advancing a locking device into the base member until at least one elongate member spans a space between adjacent portions of the helical structure to contact the cancellous bone in the space; and inserting a retention portion of a reverse articular insert into the cylindrical member of the base member to directly connect the reverse articular insert with the cylindrical member of the base member.

A humeral implant is provided. The implant includes a humeral stem including a plurality of fins. At least one fin comprises a serrated bottom edge. A radial distance between an inner bottom edge of the at least one fin and a centerline of the humeral implant increases along a distal length of extension of the at least one fin. At least the serrated bottom edge of the at least one fin is configured to cut into and compact bone of the metaphysis of a humerus toward relatively denser cancellous bone of a peripheral portion of the humerus when press-fit therein, thereby providing sufficient press-fitting for cementless fixation of the humeral stem into the humerus. Related kits and methods are also provided.

The invention discloses a self-adaptive bionic cancellous bone defect prosthesis and a design method thereof, and belongs to the technical field of medical prostheses, the prosthesis is composed of biological interface gradient microporous structure parts and a main body bionic truss supporting structure part, the biological interface gradient microporous structure parts are arranged at the two ends of the main body bionic truss supporting structure part, and the main body bionic truss supporting structure part is arranged on the main body bionic truss supporting structure part. The method is mainly used for reconstructing bone defects, bionically designing a truss part of a main body with consistent arrangement direction and form of human body bone trabecula through an established linear relation between CT gray value and bone density-elasticity modulus, adaptively matching mechanical conduction of a bone structure, reducing stress shielding effect, and improving bone defect reconstruction efficiency. Meanwhile, various complex mechanical working condition requirements of the prosthesis are met, the prosthesis failure risk is reduced, and the service life of the prosthesis is prolonged.

The invention discloses a bone scaffold fusion design and preparation method based on mirror image registration, and the method comprises the steps: firstly, based on a three-dimensional medical image of a femoral defect region of a patient, combining an opposite-side complete femoral CT image, and achieving the automatic recognition and complementation of the defect region through the mirror image transformation and ICP registration technology; after defect boundary extraction is completed, three-dimensional reconstruction is carried out on the individualized outer contour of the left bone tissue, and an STL format model is exported. According to the femur functional partition characteristics, a Diamond structure is adopted in a cortical bone area to enhance mechanical support, and a Gyandroid structure is selected in a cancellous bone area to achieve porosity gradient filling, so that the permeability is optimized, and cell proliferation is promoted. Continuous transition among the structures is realized through a Sigmoid function, and the stability and the biological adaptability of the whole structure are improved. And finally, the stent model is subjected to selective laser melting, and a Zn-3Mg alloy material is utilized to complete printing manufacturing.

The utility model discloses a 3D printing porous pedicle screw which comprises a screw body part and a screw cap part, the screw body part comprises a cortical bone thread area close to one end of the screw cap part and a cancellous bone thread area far away from one end of the screw cap part, and a porous structure area is arranged at one end, not connected with the screw cap part, of the screw body part. The porous structure area comprises an inner core column extending in the axial direction of the nail body part, at least one reinforcing beam and a porous structure, the reinforcing beams extend outwards from the periphery of the inner core column, and the porous structure is annularly distributed on the outer periphery of the inner core column. The porous structure can efficiently induce bone tissue to grow in, the screw and a vertebral body are connected into a whole, stress is effectively dispersed, the stability of the screw is improved, the porous structure is arranged on the vertebral body at the front end of the screw, screw breakage caused by stress concentration of the screw in a vertebral pedicle area can be avoided, meanwhile, the stability of the screw can be better improved through the reinforcing beam, and the service life of the screw is prolonged. The possibility of fracture of a porous area of the screw is reduced, generalization performance is better, and the use experience feeling is improved.

The embodiment of the invention provides an intelligent bone drilling self-adaptive control method for a mechanical arm, which comprises the following steps: acquiring displacement deviation of the tail end of a drill bit of an orthopedic surgical robot, obtaining an error change rate through differential calculation, and combining a bone layer type as an input variable of a fuzzy controller and a feeding speed as an output variable; input variables are fuzzified through a membership function, and a fuzzy language variable set is obtained; according to the set and a preset rule base, constructing a multi-rule group structure comprising three types of scenes of free space, cancellous bone and cortical bone, and setting corresponding fuzzy rule subsets for different bone layers; designing a ''minimum-maximum'' rule activation and combination strategy for reasoning by adopting a Mamdani type fuzzy reasoning method according to fuzzification input and a multi-rule group structure, and generating a fuzzification output variable set; and defuzzification is performed through a gravity center method to obtain a continuous speed instruction, and dynamic regulation and control of the drill bit feeding speed are achieved. When approaching a penetration point, the device automatically decelerates and safely stops, so that the safety and accuracy of an operation are effectively guaranteed, and over-drilling injury is prevented.

Methods and devices for harvesting cancellous bone are disclosed. The bone-harvesting device may include a cannula and a bone receptacle in communication with the cannula, wherein the cannula including a cutting surface positioned at or adjacent the distal end, the cutting surface being oriented at an angle, the angle being greater than 90 degrees relative to the longitudinal axis of the cannula, and the harvested bone is adapted to move from a position adjacent to the cutting surface through the cannula into the bone receptacle. The cutting surface of the cannula may be positioned at or adjacent the distal end, and positioned at least in part radially outward of the outer face of the cannula. The cannula may include a cutting surface positioned at or adjacent the distal end and an occluding geometry that partially occludes the distal end of the cannula adjacent the cutting surface. In addition, a suction port may be provided in communication with the bone receptacle.

The invention provides a lumbar cancellous bone CT value automatic calculation method and system based on deep learning, and relates to the technical field of medical image classification and segmentation. According to the method, firstly, lumbar vertebra CT images corresponding to a plurality of lumbar vertebra segments can be classified from a large number of CT images of a target object, and then threshold segmentation is carried out on the lumbar vertebra CT images based on image characteristics of the lumbar vertebra portions to obtain threshold segmentation images; then, the lumbar vertebra CT image serves as input, the threshold segmentation image serves as prompt information to be input into an image segmentation model, a lumbar vertebra cancellous bone area is obtained through segmentation, and finally the average pixel value of the lumbar vertebra cancellous bone area of each lumbar vertebra segment is obtained through calculation based on the segmentation result returned to the original Dicom-format lumbar vertebra CT image. And finally, obtaining a lumbar vertebra cancellous bone CT value result of each lumbar vertebra section. Therefore, the original Dicom data can be automatically processed, and the CT value of the lumbar cancellous bone can be accurately calculated through the deep learning model so as to assist doctors in diagnosis.

Surgical systems and methods for manipulation of an anatomy that includes cortical and cancellous bone. A surgical manipulator has a robotic arm to move an instrument with an energy applicator. A sensor senses forces / torques applied to the energy applicator. Controller(s) obtain a tool path for the energy applicator to traverse. A segment of the tool path transitions into, or between, cortical bone and cancellous bone. The controller(s) control the manipulator to advance the energy applicator along the tool path according to a first feed rate to manipulate the cortical or cancellous bone and detect, with the sensor, a change in the forces / torques being indicative of the transition. In response to detection of this change, the controller(s) control the manipulator to advance the energy applicator along the tool path according to a second feed rate, greater / less than the first feed rate.

The invention provides a gradient density metal implant additive manufacturing method, and relates to the technical field of selective laser melting additive manufacturing, according to the method, continuous gradient density distribution of a metal implant from an outer layer to an inner layer is achieved through multi-mode sensor fusion and a self-adaptive control algorithm, biomechanical characteristics of a skeleton are accurately simulated, and the manufacturing precision of the metal implant is improved. The step of designing a porous structure is omitted; cortical bone (high density) and cancellous bone (porous) structures of human bones can be accurately simulated, and the biomechanical suitability of the implant is improved.

The invention relates to a spine bone structure and bone mineral density automatic measurement method based on a CT image. The method comprises the following steps: performing CT scanning on a phantom with known bone mineral density to obtain a real bone mineral density calculation formula; all CT images in the DICOM format are read, DICOM analysis is carried out, and three-dimensional CT value data and other main information of all the images are obtained; performing outer contour segmentation on the whole spine in the CT image by using a deep learning network to obtain an outer contour of each vertebral body in the image; the method comprises the following steps: carrying out preliminary segmentation on cortical bones and cancellous bones by adopting a dynamic threshold method aiming at each vertebral body, selecting a preliminarily segmented cancellous bone region, using a maximum connected domain algorithm in a three-dimensional direction, retaining a maximum connected region, and further measuring the bone mineral density, namely calculating overall topology parameters, the bone mineral density and the bone mineral content of the current vertebral body; calculating the rubbing parameters, the bone mineral density and the bone mineral content of the current vertebral cortical bone and cancellous bone; and measuring the content of the cross section of the cone.

The invention discloses a fine-grained segmentation method and system for a three-dimensional CBCT skull image. The method comprises the following steps: firstly, constructing a first training data set; thirdly, in combination with the first training data set, training the secondary segmentation neural network model to obtain a trained secondary segmentation neural network model; then, segmenting a to-be-processed three-dimensional CBCT skull image by using the trained secondary segmentation neural network model to obtain a segmentation result of each structure of the skull; and finally, segmenting the bone cortex and cancellous bone of the upper and lower jawbones by using an improved region growing method to obtain a bone cortex and cancellous bone segmentation result corresponding to the upper and lower jawbones, thereby completing fine-grained segmentation of the three-dimensional CBCT skull image. According to the method provided by the invention, fine-grained areas of the oral maxillofacial region can be separated, and the fine-grained areas comprise intact skull, upper and lower jawbone, teeth, bone cortex, cancellous bone, neural tubes, maxillary sinus, incisor canals and other structures.

The utility model belongs to the technical field of medical instruments, and particularly relates to a 3D printing expandable interbody fusion cage which comprises a fusion cage body, and the fusion cage body comprises a screw, a fixing pin, a transverse pin, a frame body, an upper base plate, a lower base plate and a supporting sliding block arranged between the upper base plate and the lower base plate. The distractable interbody fusion cage and intervertebral contact parts are manufactured by using a 3D printing technology, and three-dimensional porous structures similar to cancellous bone structures are designed on the surfaces of the upper base plate and the lower base plate, so that the fusion rate of the interbody fusion cage and the spine of a human body can be increased; meanwhile, the interbody fusion cage is simple in structure and convenient to operate, is implanted into the interbody space of the human body in a contracted state, is expanded in situ, can increase the contact area with an end plate and the bone chip filling space, can recover the forward convex curvature, has high biomechanical stability, is suitable for various lumbar degenerative diseases needing interbody fusion, and can be widely applied to the field of lumbar interbody fusion. The clinical treatment effect can be effectively improved.

The invention relates to the technical field of medical implants, in particular to a 4D printing-based porous Niti alloy bionic bone gradient structure construction method, which comprises the steps of patient bone data acquisition, bionic gradient model design, NiTi powder preparation, 4D printing, thermal treatment activation of memory effect, surface functionalization treatment and mechanical / biological performance test. The method is characterized by comprising the following preparation steps: accurately acquiring bone structure data through CT / MRI, combining Mimics pretreatment and UG / NX modeling, designing aperture and porosity for differentiation of cortical bone (low porosity of 30%-40%) and cancellous bone (high porosity of 50%-70%), simulating typical load working conditions through ANSYS, enabling the elastic modulus (3-15 GPa) and compressive strength (80-200 MPa) to be close to natural bone, and finally obtaining the bone structure data through the CT / MRI, the pore diameter and porosity of the cortical bone (low porosity of 30%-40%) and the porosity of the cancellous bone (high porosity of 50%-70%). According to the design, the elastic modulus difference between the implant and the host bone is remarkably reduced, the bone resorption problem caused by stress shielding is avoided, meanwhile, continuous porosity transition is achieved through the power gradual change technology, and the structural stability under the complex load is improved.

The invention discloses a shape memory alloy bone scaffold imitating a Haversian system as well as a 4D printing preparation method and application of the shape memory alloy bone scaffold. According to the 4D printing preparation method, the stress state and function requirements of the bone scaffold are fully considered, a bone scaffold porous structure with an imitated Haversian system is designed by adopting a function bionic method, and the bone scaffold is prepared by adopting a 4D printing technology. The inner layer imitated cancellous bone porous structure designed in the preparation method not only meets the requirement that the inner layer has good elasticity and toughness, but also facilitates cell adhesion to guide cell growth and maintains blood supply; the designed artificial cortical bone porous structure with the Haversian system on the outer layer meets the requirement that the outer layer has good compression resistance and bending resistance, and the Haversian system is more beneficial to ingrowth of blood vessels and nerves and maintains skeleton metabolism and repair. The shape memory alloy bone scaffold simulating the Haversian system, disclosed by the invention, has a wide application prospect in the field of bone implants.

The invention provides an application of a composition in preparation of a bone repair material, the composition is prepared from the following materials in percentage by weight: 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen and 0-7% of an excipient, the bone repair material is a cancellous bone imitating material, and the porosity is 85%-99%. The composition provided by the invention has high porosity and a warp-wise gradient structure, can simulate the characteristics of natural bone tissues, has excellent biocompatibility, biodegradability, hydrophilicity, osteogenesis performance and shape memory function, and has excellent clinical use convenience, hemostasis and healing promotion effects and excellent osteogenesis effect; the bone repair material has a wide application prospect in the aspect of preparing the bone repair material for filling and / or repairing bone defects.

An attachment device with a radially expandable section is disclosed. The attachment device can have helical threads, for example, to facilitate screwing the attachment device into a bone. Methods of using the same are also disclosed. The attachment device can be positioned to radially expand the expandable section in cancellous bone substantially surrounded by cortical bone.

The invention provides a natural bone repair material and a preparation method thereof. The material is animal cancellous bone inorganic salt particles or animal cancellous bone inorganic salt bone slices; the invention also relates to a preparation method of the natural bone repair material. The preparation method sequentially comprises the following steps: selecting materials, crushing, cleaning, removing organic matters, efficiently cleaning and drying, calcining and sterilizing. According to the method, inorganic base heating extraction and low-temperature calcination are adopted, so that the method is non-toxic, harmless, safe, efficient, low in organic matter residue and small in damage to the structure of a natural bone material, and the structure and morphology of the natural bone are better reserved; the defects of long construction period, low efficiency, high cost and the like existing in high-temperature calcination and organic reagent removal are avoided. The size of the bone repair material can be controlled, and the obtained bone repair material has certain mechanical strength, is not easy to break after being filled, and can play a good supporting role; and the material also has the advantages of high specific surface area, high porosity, low crystallinity, good hydrophilic performance, good biocompatibility and the like, and is suitable for bone defect repair.

The invention provides a carbon fiber intramedullary nail and a preparation method thereof, and relates to the technical field of orthopedic implants, at least two layers of outer layer fibers are spirally wound around a central fiber to prepare a hybrid fiber composite rope strand; the hybrid fiber composite rope strands are axially loaded and twisted with the core mold as the center, a spiral carbon fiber prefabricated body is formed, and a mold is pre-buried in the carbon fiber prefabricated body to form screw holes; the carbon fiber prefabricated body is sequentially subjected to hot pressing, cooling and heat treatment, the carbon fiber intramedullary nail is obtained, and fibers of the hybrid fiber composite rope strand comprise polyaryletherketone resin fibers, carbon fibers and biodegradable metal fibers. The biodegradable metal fiber is used as a pore-forming fiber, a series of porous intramedullary nails with accurate pore size distribution can be obtained, and the porous intramedullary nails have the characteristics of cancellous bone-like hierarchical pore sizes while having high connectivity; by means of gradual degradation of the metal fibers in the body, the nail body is gradually transited from firm fixation to biological fixation, the human skeleton healing cycle is matched, and the purpose of precise healing is achieved.

The present invention discloses a bionic lumbar spine bone with X-ray imaging and its preparation method, which relates to the field of bionic technology of medical polymer materials. The technical solution is to stir and mix the raw materials of rigid polyurethane foam and then pour them into a lumbar spine bone mold for foaming to prepare the cancellous bone material of the bionic lumbar spine bone; use the blend modification of styrene-acrylic emulsion and SAN emulsion to prepare the material for bionic cortical bone; and then use the spraying or dipping process to attach the prepared cortical bone to the outer surface of the cancellous bone to form a bionic lumbar spine bone with X-ray imaging. By adding a water-soluble imaging agent in the emulsion synthesis, the present invention realizes the fine distribution of the imaging agent, significantly improves the contrast and clarity of X-ray imaging. Compared with the traditional materials relying on high-concentration inorganic imaging agents, the water-soluble imaging agent not only improves the biocompatibility and environmental protection, but also strengthens the hardness and wear resistance of the material through SAN resin, is applicable to diversified medical and industrial applications, and shows broad market potential.

An osteogenic composition comprises growth-factor augmented cortical bone and cancellous bone having viable endogenous osteogenic cells that remain adherent to the cancellous bone. The growth-factor augmented cortical bone comprises demineralized cortical bone amplified with growth factors derived from a demineralized bone, and the cancellous bone not having been subjected to a loosening agent. The osteogenic composition is cryopreserved or lyopreserved. A method for preparing an enhanced graft composition with improved osteoinductive properties includes processing demineralized cortical bone; solubilizing growth factors from demineralized bone; and mixing the demineralized cortical bone with the solubilized growth factors.

The invention discloses a machine learning model construction method for predicting lumbar vertebra bone mineral density based on a CT image. The method comprises the following steps: step 1, image acquisition: collecting images and data including lumbar vertebra CT of a patient; step 2, image segmentation: on the cross section of each CT image, using ITK-SNAP software to carry out ROI segmentation on the cancellous bone part of the vertebral body so as to ensure that the construction of the model can reflect a cancellous bone part result which can best represent the real bone mineral density; step 3, performing deep learning by using DenseNet: realizing training and testing of a Densenet model on the basis of a Pytorch framework; and 4, performing verification by using the trained model: after the training is completed, evaluating the performance of the trained model by using a verification data set. According to the method, the patients in the training set and the test set are strictly screened, influence factors possibly causing inaccurate bone mineral density results are eliminated, results more conforming to actual bone mineral density values of vertebral bodies can be given, and the method has more clinical significance on lumbar surgery and bone mineral density treatment.

The invention discloses a bone-like osteoma microwave ablation thermal injury assessment method based on all-optical parameters, which comprises the following steps: respectively considering thermal injury models of cortical bone and cancellous bone under different microwave ablation conditions by constructing a simulation model conforming to bone tissue characteristics; according to the method, construction of an incomplete P5 approximation model is proposed, bone tissue all-optical parameter anti-construction research based on steady-state radiance is carried out, the accuracy is high, calculation is convenient, temperature parameters and biological tissue all-optical parameters are analyzed in a combined mode, a tissue thermal damage model of the temperature and tissue all-optical parameters is established through theoretical research, and due to the characteristics of different bone tissues, the tissue thermal damage model can be used as a tissue thermal damage model of the temperature and tissue all-optical parameters. The tissue types are considered in the thermal damage model, and effective bone tissue thermal damage factors are designed based on different tissues, so that the evaluation accuracy is ensured.

The present invention provides a proximal femoral cancellous bone harvesting and implanting device, belonging to the field of medical device technology. The device comprises a femoral head X and a cancellous bone harvesting region Y at the distal end of the femoral head. The device comprises an outer tube, the outer tube comprising a lower sleeve and an upper sleeve, a connecting mechanism being provided between the lower sleeve and the upper sleeve, the connecting mechanism enabling an adjustable angle between the lower sleeve and the upper sleeve, the central axis of the lower sleeve being arranged along the bone harvesting region Y toward the femoral head X, the lower sleeve being implanted into the femoral body to establish a bone harvesting and implanting channel, the lower sleeve, the upper sleeve, the inner tube, and the connecting mechanism being provided in the present invention cooperating with each other to achieve bone harvesting and implanting operations, eliminating the need to replace instruments during the bone harvesting and implanting processes, and facilitating operation. Specifically, the inner tube can be simultaneously passed through the upper sleeve and the socket member to reach the bone harvesting region Y for bone harvesting, or the inner tube can be simultaneously passed through the lower sleeve and the upper sleeve to reach the interior of the femoral head X for bone implanting.

The invention discloses a porosity gradient discrete embedded type composite bone tissue modeling method. The method comprises the following steps: establishing a three-phase composite bone tissue geometric model of cortical bone, cancellous bone and cortical bone with discrete random pores; establishing material constitutive models of a cortical bone model and a cancellous bone model in the three-phase composite bone tissue geometric model; and performing grid division on the three-phase composite bone tissue geometric model to obtain a composite bone tissue model. According to the porosity gradient discrete embedded type composite bone tissue modeling method, the composite structure of the bone tissue in transition from cortical bone to cancellous bone can be effectively simulated, the accuracy of bone model simulation is improved, and the problem of constitutive homogeneous distortion of an existing bone tissue cutting simulation material is solved.

The invention relates to the technical field of cancellous bone scaffolds, and discloses a topological optimization-based cancellous bone scaffold reverse generation model determination method and device, in the method, a three-dimensional thin layer structure is subjected to topological optimization processing, and complex and irregular microstructure characteristics of cancellous bone tissues can be simulated. The first multi-channel mechanical nephogram and the second multi-channel mechanical nephogram are force-related features. And multi-modal data composed of the three-dimensional thin-layer structure, the initial simplified model, the first multi-channel mechanical cloud picture and the second multi-channel mechanical cloud picture is used as a training sample to train a potential map diffusion model, so that the model can obtain strong performance of outputting a cancellous bone scaffold result under the training of a multi-modal input condition.

The utility model belongs to the technical field of medical instruments, and relates to a joint implant for the orthopedics department. The joint implant is used for joint bone cartilage injury and defect repair and comprises a joint implant base body with a porous titanium structure and a top solid self-lubricating film. The joint implant base includes a top region, an upper region, and a lower region. The top area is matched with the outer contour face of the human body bone and is of a dense mirror face structure, the surface of the top area is plated with a solid self-lubricating film, abrasion to the opposite-side cartilage can be reduced to a large extent, and degeneration of the opposite-side cartilage is reduced. The side faces of the top area and the upper area of the joint implant base body make contact with subchondral bones and cancellous bones of the human body, and the lower area of the joint implant base body makes contact with the cancellous bones of the human body. The aperture and porosity of the joint implant base body extend from the upper area to the lower area, are increased in a gradient manner, are matched with the mechanical properties of human bones, and are beneficial to initial stability, early-stage rapid bone ingrowth and long-term stability.

Methods and devices for plugging a hole bone are disclosed. The bone plug device may include a polymeric mesh structure and a first and a second solid polymeric structure mounted or formed onto a first and a second corresponding leaflet of the polymeric mesh structure. When inserted into a hole in cortical bone, the polymeric mesh structure moves from an open configuration to a closed configuration, reducing the diameter of the polymeric mesh structure and causing the first solid polymeric structure to contact the second solid polymeric structure, conforming bone plug device to the hole. The polymeric mesh structure is configured to mimic cancellous bone structure and porosity to encourage cancellous bone ingrowth.