172 results about "Cancellous bone" patented technology

The invention discloses a tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data, and belongs to the field of artificial intelligence and computer-aided biomedical engineering. The method comprises a CBCT intelligent segmentation module, an intraoral scanning intelligent segmentation module, an internal tissue segmentation module, a point cloud generation registration module and a parameterized bionic reconstruction module. The point cloud generation registration module further comprises a point cloud generation sub-module and a point cloud registration sub-module; the parameterized bionic reconstruction module further comprises a dentin reconstruction sub-module, a cancellous bone reconstruction sub-module and a gingival reconstruction sub-module. The invention aims to realize tooth semantic segmentation, point cloud reconstruction and parameterized bionic modeling of an organization structure under cross-modal data fusion, and provides high-precision bionic internal structure information for teeth in combination with an artificial intelligence model and parameterized modeling.

A method of implanting a shoulder prosthesis assembly is provided where the method includes advancing by rotation a base member, that includes a cylindrical member and a helical structure, into a resection face of a humerus of a patient such that the helical structure is submerged in and engages cancellous bone of and does not extend distally of an epiphysis of the humerus, the cylindrical member being accessible at the resection face of the humerus when the base member is so advanced; advancing a locking device into the base member until at least one elongate member spans a space between adjacent portions of the helical structure to contact the cancellous bone in the space; and inserting a retention portion of a reverse articular insert into the cylindrical member of the base member to directly connect the reverse articular insert with the cylindrical member of the base member.

A humeral implant is provided. The implant includes a humeral stem including a plurality of fins. At least one fin comprises a serrated bottom edge. A radial distance between an inner bottom edge of the at least one fin and a centerline of the humeral implant increases along a distal length of extension of the at least one fin. At least the serrated bottom edge of the at least one fin is configured to cut into and compact bone of the metaphysis of a humerus toward relatively denser cancellous bone of a peripheral portion of the humerus when press-fit therein, thereby providing sufficient press-fitting for cementless fixation of the humeral stem into the humerus. Related kits and methods are also provided.

The invention discloses a self-adaptive bionic cancellous bone defect prosthesis and a design method thereof, and belongs to the technical field of medical prostheses, the prosthesis is composed of biological interface gradient microporous structure parts and a main body bionic truss supporting structure part, the biological interface gradient microporous structure parts are arranged at the two ends of the main body bionic truss supporting structure part, and the main body bionic truss supporting structure part is arranged on the main body bionic truss supporting structure part. The method is mainly used for reconstructing bone defects, bionically designing a truss part of a main body with consistent arrangement direction and form of human body bone trabecula through an established linear relation between CT gray value and bone density-elasticity modulus, adaptively matching mechanical conduction of a bone structure, reducing stress shielding effect, and improving bone defect reconstruction efficiency. Meanwhile, various complex mechanical working condition requirements of the prosthesis are met, the prosthesis failure risk is reduced, and the service life of the prosthesis is prolonged.

The invention discloses a bone scaffold fusion design and preparation method based on mirror image registration, and the method comprises the steps: firstly, based on a three-dimensional medical image of a femoral defect region of a patient, combining an opposite-side complete femoral CT image, and achieving the automatic recognition and complementation of the defect region through the mirror image transformation and ICP registration technology; after defect boundary extraction is completed, three-dimensional reconstruction is carried out on the individualized outer contour of the left bone tissue, and an STL format model is exported. According to the femur functional partition characteristics, a Diamond structure is adopted in a cortical bone area to enhance mechanical support, and a Gyandroid structure is selected in a cancellous bone area to achieve porosity gradient filling, so that the permeability is optimized, and cell proliferation is promoted. Continuous transition among the structures is realized through a Sigmoid function, and the stability and the biological adaptability of the whole structure are improved. And finally, the stent model is subjected to selective laser melting, and a Zn-3Mg alloy material is utilized to complete printing manufacturing.

The utility model discloses a 3D printing porous pedicle screw which comprises a screw body part and a screw cap part, the screw body part comprises a cortical bone thread area close to one end of the screw cap part and a cancellous bone thread area far away from one end of the screw cap part, and a porous structure area is arranged at one end, not connected with the screw cap part, of the screw body part. The porous structure area comprises an inner core column extending in the axial direction of the nail body part, at least one reinforcing beam and a porous structure, the reinforcing beams extend outwards from the periphery of the inner core column, and the porous structure is annularly distributed on the outer periphery of the inner core column. The porous structure can efficiently induce bone tissue to grow in, the screw and a vertebral body are connected into a whole, stress is effectively dispersed, the stability of the screw is improved, the porous structure is arranged on the vertebral body at the front end of the screw, screw breakage caused by stress concentration of the screw in a vertebral pedicle area can be avoided, meanwhile, the stability of the screw can be better improved through the reinforcing beam, and the service life of the screw is prolonged. The possibility of fracture of a porous area of the screw is reduced, generalization performance is better, and the use experience feeling is improved.

The embodiment of the invention provides an intelligent bone drilling self-adaptive control method for a mechanical arm, which comprises the following steps: acquiring displacement deviation of the tail end of a drill bit of an orthopedic surgical robot, obtaining an error change rate through differential calculation, and combining a bone layer type as an input variable of a fuzzy controller and a feeding speed as an output variable; input variables are fuzzified through a membership function, and a fuzzy language variable set is obtained; according to the set and a preset rule base, constructing a multi-rule group structure comprising three types of scenes of free space, cancellous bone and cortical bone, and setting corresponding fuzzy rule subsets for different bone layers; designing a ''minimum-maximum'' rule activation and combination strategy for reasoning by adopting a Mamdani type fuzzy reasoning method according to fuzzification input and a multi-rule group structure, and generating a fuzzification output variable set; and defuzzification is performed through a gravity center method to obtain a continuous speed instruction, and dynamic regulation and control of the drill bit feeding speed are achieved. When approaching a penetration point, the device automatically decelerates and safely stops, so that the safety and accuracy of an operation are effectively guaranteed, and over-drilling injury is prevented.

The invention provides a lumbar cancellous bone CT value automatic calculation method and system based on deep learning, and relates to the technical field of medical image classification and segmentation. According to the method, firstly, lumbar vertebra CT images corresponding to a plurality of lumbar vertebra segments can be classified from a large number of CT images of a target object, and then threshold segmentation is carried out on the lumbar vertebra CT images based on image characteristics of the lumbar vertebra portions to obtain threshold segmentation images; then, the lumbar vertebra CT image serves as input, the threshold segmentation image serves as prompt information to be input into an image segmentation model, a lumbar vertebra cancellous bone area is obtained through segmentation, and finally the average pixel value of the lumbar vertebra cancellous bone area of each lumbar vertebra segment is obtained through calculation based on the segmentation result returned to the original Dicom-format lumbar vertebra CT image. And finally, obtaining a lumbar vertebra cancellous bone CT value result of each lumbar vertebra section. Therefore, the original Dicom data can be automatically processed, and the CT value of the lumbar cancellous bone can be accurately calculated through the deep learning model so as to assist doctors in diagnosis.

Surgical systems and methods for manipulation of an anatomy that includes cortical and cancellous bone. A surgical manipulator has a robotic arm to move an instrument with an energy applicator. A sensor senses forces / torques applied to the energy applicator. Controller(s) obtain a tool path for the energy applicator to traverse. A segment of the tool path transitions into, or between, cortical bone and cancellous bone. The controller(s) control the manipulator to advance the energy applicator along the tool path according to a first feed rate to manipulate the cortical or cancellous bone and detect, with the sensor, a change in the forces / torques being indicative of the transition. In response to detection of this change, the controller(s) control the manipulator to advance the energy applicator along the tool path according to a second feed rate, greater / less than the first feed rate.

The invention provides a gradient density metal implant additive manufacturing method, and relates to the technical field of selective laser melting additive manufacturing, according to the method, continuous gradient density distribution of a metal implant from an outer layer to an inner layer is achieved through multi-mode sensor fusion and a self-adaptive control algorithm, biomechanical characteristics of a skeleton are accurately simulated, and the manufacturing precision of the metal implant is improved. The step of designing a porous structure is omitted; cortical bone (high density) and cancellous bone (porous) structures of human bones can be accurately simulated, and the biomechanical suitability of the implant is improved.

The invention relates to a spine bone structure and bone mineral density automatic measurement method based on a CT image. The method comprises the following steps: performing CT scanning on a phantom with known bone mineral density to obtain a real bone mineral density calculation formula; all CT images in the DICOM format are read, DICOM analysis is carried out, and three-dimensional CT value data and other main information of all the images are obtained; performing outer contour segmentation on the whole spine in the CT image by using a deep learning network to obtain an outer contour of each vertebral body in the image; the method comprises the following steps: carrying out preliminary segmentation on cortical bones and cancellous bones by adopting a dynamic threshold method aiming at each vertebral body, selecting a preliminarily segmented cancellous bone region, using a maximum connected domain algorithm in a three-dimensional direction, retaining a maximum connected region, and further measuring the bone mineral density, namely calculating overall topology parameters, the bone mineral density and the bone mineral content of the current vertebral body; calculating the rubbing parameters, the bone mineral density and the bone mineral content of the current vertebral cortical bone and cancellous bone; and measuring the content of the cross section of the cone.

The invention discloses a fine-grained segmentation method and system for a three-dimensional CBCT skull image. The method comprises the following steps: firstly, constructing a first training data set; thirdly, in combination with the first training data set, training the secondary segmentation neural network model to obtain a trained secondary segmentation neural network model; then, segmenting a to-be-processed three-dimensional CBCT skull image by using the trained secondary segmentation neural network model to obtain a segmentation result of each structure of the skull; and finally, segmenting the bone cortex and cancellous bone of the upper and lower jawbones by using an improved region growing method to obtain a bone cortex and cancellous bone segmentation result corresponding to the upper and lower jawbones, thereby completing fine-grained segmentation of the three-dimensional CBCT skull image. According to the method provided by the invention, fine-grained areas of the oral maxillofacial region can be separated, and the fine-grained areas comprise intact skull, upper and lower jawbone, teeth, bone cortex, cancellous bone, neural tubes, maxillary sinus, incisor canals and other structures.

The invention relates to the technical field of medical implants, in particular to a 4D printing-based porous Niti alloy bionic bone gradient structure construction method, which comprises the steps of patient bone data acquisition, bionic gradient model design, NiTi powder preparation, 4D printing, thermal treatment activation of memory effect, surface functionalization treatment and mechanical / biological performance test. The method is characterized by comprising the following preparation steps: accurately acquiring bone structure data through CT / MRI, combining Mimics pretreatment and UG / NX modeling, designing aperture and porosity for differentiation of cortical bone (low porosity of 30%-40%) and cancellous bone (high porosity of 50%-70%), simulating typical load working conditions through ANSYS, enabling the elastic modulus (3-15 GPa) and compressive strength (80-200 MPa) to be close to natural bone, and finally obtaining the bone structure data through the CT / MRI, the pore diameter and porosity of the cortical bone (low porosity of 30%-40%) and the porosity of the cancellous bone (high porosity of 50%-70%). According to the design, the elastic modulus difference between the implant and the host bone is remarkably reduced, the bone resorption problem caused by stress shielding is avoided, meanwhile, continuous porosity transition is achieved through the power gradual change technology, and the structural stability under the complex load is improved.

The invention provides an application of a composition in preparation of a bone repair material, the composition is prepared from the following materials in percentage by weight: 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen and 0-7% of an excipient, the bone repair material is a cancellous bone imitating material, and the porosity is 85%-99%. The composition provided by the invention has high porosity and a warp-wise gradient structure, can simulate the characteristics of natural bone tissues, has excellent biocompatibility, biodegradability, hydrophilicity, osteogenesis performance and shape memory function, and has excellent clinical use convenience, hemostasis and healing promotion effects and excellent osteogenesis effect; the bone repair material has a wide application prospect in the aspect of preparing the bone repair material for filling and / or repairing bone defects.

The invention provides a natural bone repair material and a preparation method thereof. The material is animal cancellous bone inorganic salt particles or animal cancellous bone inorganic salt bone slices; the invention also relates to a preparation method of the natural bone repair material. The preparation method sequentially comprises the following steps: selecting materials, crushing, cleaning, removing organic matters, efficiently cleaning and drying, calcining and sterilizing. According to the method, inorganic base heating extraction and low-temperature calcination are adopted, so that the method is non-toxic, harmless, safe, efficient, low in organic matter residue and small in damage to the structure of a natural bone material, and the structure and morphology of the natural bone are better reserved; the defects of long construction period, low efficiency, high cost and the like existing in high-temperature calcination and organic reagent removal are avoided. The size of the bone repair material can be controlled, and the obtained bone repair material has certain mechanical strength, is not easy to break after being filled, and can play a good supporting role; and the material also has the advantages of high specific surface area, high porosity, low crystallinity, good hydrophilic performance, good biocompatibility and the like, and is suitable for bone defect repair.

The present invention discloses a bionic lumbar spine bone with X-ray imaging and its preparation method, which relates to the field of bionic technology of medical polymer materials. The technical solution is to stir and mix the raw materials of rigid polyurethane foam and then pour them into a lumbar spine bone mold for foaming to prepare the cancellous bone material of the bionic lumbar spine bone; use the blend modification of styrene-acrylic emulsion and SAN emulsion to prepare the material for bionic cortical bone; and then use the spraying or dipping process to attach the prepared cortical bone to the outer surface of the cancellous bone to form a bionic lumbar spine bone with X-ray imaging. By adding a water-soluble imaging agent in the emulsion synthesis, the present invention realizes the fine distribution of the imaging agent, significantly improves the contrast and clarity of X-ray imaging. Compared with the traditional materials relying on high-concentration inorganic imaging agents, the water-soluble imaging agent not only improves the biocompatibility and environmental protection, but also strengthens the hardness and wear resistance of the material through SAN resin, is applicable to diversified medical and industrial applications, and shows broad market potential.

An osteogenic composition comprises growth-factor augmented cortical bone and cancellous bone having viable endogenous osteogenic cells that remain adherent to the cancellous bone. The growth-factor augmented cortical bone comprises demineralized cortical bone amplified with growth factors derived from a demineralized bone, and the cancellous bone not having been subjected to a loosening agent. The osteogenic composition is cryopreserved or lyopreserved. A method for preparing an enhanced graft composition with improved osteoinductive properties includes processing demineralized cortical bone; solubilizing growth factors from demineralized bone; and mixing the demineralized cortical bone with the solubilized growth factors.

The invention discloses a machine learning model construction method for predicting lumbar vertebra bone mineral density based on a CT image. The method comprises the following steps: step 1, image acquisition: collecting images and data including lumbar vertebra CT of a patient; step 2, image segmentation: on the cross section of each CT image, using ITK-SNAP software to carry out ROI segmentation on the cancellous bone part of the vertebral body so as to ensure that the construction of the model can reflect a cancellous bone part result which can best represent the real bone mineral density; step 3, performing deep learning by using DenseNet: realizing training and testing of a Densenet model on the basis of a Pytorch framework; and 4, performing verification by using the trained model: after the training is completed, evaluating the performance of the trained model by using a verification data set. According to the method, the patients in the training set and the test set are strictly screened, influence factors possibly causing inaccurate bone mineral density results are eliminated, results more conforming to actual bone mineral density values of vertebral bodies can be given, and the method has more clinical significance on lumbar surgery and bone mineral density treatment.

The invention discloses a bone-like osteoma microwave ablation thermal injury assessment method based on all-optical parameters, which comprises the following steps: respectively considering thermal injury models of cortical bone and cancellous bone under different microwave ablation conditions by constructing a simulation model conforming to bone tissue characteristics; according to the method, construction of an incomplete P5 approximation model is proposed, bone tissue all-optical parameter anti-construction research based on steady-state radiance is carried out, the accuracy is high, calculation is convenient, temperature parameters and biological tissue all-optical parameters are analyzed in a combined mode, a tissue thermal damage model of the temperature and tissue all-optical parameters is established through theoretical research, and due to the characteristics of different bone tissues, the tissue thermal damage model can be used as a tissue thermal damage model of the temperature and tissue all-optical parameters. The tissue types are considered in the thermal damage model, and effective bone tissue thermal damage factors are designed based on different tissues, so that the evaluation accuracy is ensured.

The present invention provides a proximal femoral cancellous bone harvesting and implanting device, belonging to the field of medical device technology. The device comprises a femoral head X and a cancellous bone harvesting region Y at the distal end of the femoral head. The device comprises an outer tube, the outer tube comprising a lower sleeve and an upper sleeve, a connecting mechanism being provided between the lower sleeve and the upper sleeve, the connecting mechanism enabling an adjustable angle between the lower sleeve and the upper sleeve, the central axis of the lower sleeve being arranged along the bone harvesting region Y toward the femoral head X, the lower sleeve being implanted into the femoral body to establish a bone harvesting and implanting channel, the lower sleeve, the upper sleeve, the inner tube, and the connecting mechanism being provided in the present invention cooperating with each other to achieve bone harvesting and implanting operations, eliminating the need to replace instruments during the bone harvesting and implanting processes, and facilitating operation. Specifically, the inner tube can be simultaneously passed through the upper sleeve and the socket member to reach the bone harvesting region Y for bone harvesting, or the inner tube can be simultaneously passed through the lower sleeve and the upper sleeve to reach the interior of the femoral head X for bone implanting.

The invention relates to the technical field of cancellous bone scaffolds, and discloses a topological optimization-based cancellous bone scaffold reverse generation model determination method and device, in the method, a three-dimensional thin layer structure is subjected to topological optimization processing, and complex and irregular microstructure characteristics of cancellous bone tissues can be simulated. The first multi-channel mechanical nephogram and the second multi-channel mechanical nephogram are force-related features. And multi-modal data composed of the three-dimensional thin-layer structure, the initial simplified model, the first multi-channel mechanical cloud picture and the second multi-channel mechanical cloud picture is used as a training sample to train a potential map diffusion model, so that the model can obtain strong performance of outputting a cancellous bone scaffold result under the training of a multi-modal input condition.

The patent refers to a dental self-tapping implant comprising a body having a longitudinal body axis and a length, the body having a proximal neck portion, a proximal-central straight portion of substantially constant body diameter and a distal conical portion of decreasing diameter, the body comprising a core with a thread provided thereon, and a flute of circular arc shape formed in the thread which runs helicoidally around the core the flute having a longitudinal flute axis. The body has two segments: a cortical segment next to the proximal neck portion, a spongiosa segment extending the cortical segment the spongiosa segment including the distal conical portion, the sum of the cortical segment and the spongiosa segment being equal to the sum of the proximal-central straight portion and the distal conical portion; the flute is configured to run helicoidally around the core until it reaches the neck portion, so that the longitudinal flute axis forms a first angle with the longitudinal body axis along the cortical segment, and forms a second angle with the longitudinal body axis along the spongiosa segment; the first angle is larger than the second angle, the value of the first angle is directly proportional to the body diameter with a proportionality parameter within the interval [11;18], preferably within the interval [13,15].The patent further refers to a set comprising a dental self-tapping implant and a multi-step drill configured for the dental self-tapping implant, where the multi-step drill has four steps along the spongiosa segment, each step having a drill diameter and a step height; the drill diameters increase from the portion of the multi-step drill corresponding to the distal conical portion to the proximal-central straight portion; the body diameter is greater than the drill diameters at each step height; the step heights along the spongiosa segment have respective predetermined values irrespective of the body diameter; the drill diameters increase with the respective body diameter.

Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.

The invention is a construct consisting of a fully-threaded screw with an attached locking bolt that secures the posterior pelvis in a transiliac transsacral fashion, in the setting of an unstable posterior pelvic ring fracture. One part of the implant is a cannulated screw that has two pitches of different threads, which is placed over a guidewire and secured on the opposite side with a cannulated locking bolt that affixes to the screw. Washers on either side of the implant provide compression, and cancellous threads across the length provide fixation within the sacrum and the iliac bones on either side. This invention provides added strength and stability compared to current fixation methods consisting of screws in isolation.

This invention provides an internal fixation device for cancellous bone, belonging to the field of medical device technology. It includes a fixation plate with a plurality of screw holes and positioning holes arranged in a linear array on its top outer wall; and a guide assembly connected to the fixation plate, used to guide the hollow self-drilling screws. By incorporating the guide assembly, this invention not only guides the hollow self-drilling screws, preventing them from deviating from their pre-operatively assessed position during insertion, thus affecting their fixation effect on the fracture site, but also holds the screws during the guiding process, preventing the screw head from tilting and protruding, which could cause skin irritation and affect postoperative recovery.

The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

The invention relates to the technical field of bone repair materials, in particular to a horse antler powder support material preparation device and system, and the device comprises an ossification degree pretreatment unit, a crushing unit, a mixing unit, a printing unit and a regulation and control unit; the ossification degree pretreatment unit comprises a transmission table and a controller, a positioning conveying assembly is arranged on the surface of a transmission part of the transmission table, and a detection assembly and a cutting assembly are arranged on a support part of the transmission table; the preparation system comprises an ossification degree pretreatment module, an air pressure crushing module, a proportioning and mixing module, a 3D printing module and a degradation rate regulation and control module. According to the method, ossification degree grading pretreatment is carried out on the raw material antler, precise recognition and directional cutting are carried out on a cancellous bone region, a compact bone mass core is removed, and the problems of active ingredient fluctuation and non-uniform pore structure caused by individual difference of ossification degrees are solved.

The application relates to a medical orthopedic quick drill bit, which comprises a drill bit body composed of a drill bit part and a drill rod part, wherein the drill bit part is provided with circularly arranged cutting edges for bone positioning and hole forming, and the drill rod part is designed as a light rod; a connecting piece is connected with the drill bit body at one end and fixed with a driving piece at the other end, and the two are quickly separated through a split device containing a clamping piece and a disengaging piece, so that safe disconnection is ensured when the pressure of the medullary cavity or cancellous bone is abnormal. The application has the technical effects of improving the operation efficiency, enhancing the safety and reducing accidental injuries.

The invention relates to the technical field of medical instruments, in particular to an interbody fusion cage which comprises an interbody fusion cage body, the interbody fusion cage body is of a polyhedral structure and is implanted into the lumbar intervertebral space through an anterior lateral approach, and a screw channel and a connecting screw opening are formed in the front end position and the rear end position in the length direction of the interbody fusion cage body respectively; the screw channel is used for allowing screws to penetrate through the upper surface and the lower surface of the interbody fusion cage body, connected with the vertebral cancellous bone in a matched mode and fixed to the inner side of the lateral portion of the vertebral cancellous bone. The connecting screw is used for being connected with an installation instrument in a matched mode when the interbody fusion cage is implanted. By means of the screw channel, the fixing capacity of the interbody fusion cage can be effectively improved, better stability can be effectively provided for an OLIF operation through a proper implantation position and screw placement internal fixing operation, the occurrence risk of postoperative internal fixing related complications is effectively reduced, and the safety of the interbody fusion cage is improved. The effectiveness and the safety of the fusion cage in the lumbar vertebra front and outer side approach interbody fusion operation are improved.

The embodiment of the disclosure relates to a computer tomography image-based acetabular cup prediction system and method, and relates to the technical field of medical image analysis, and the user information and the computer tomography image of a target user are acquired; the computer tomography image is subjected to image segmentation, and an acetabular region of interest is acquired; the corresponding Hounsfield unit value and the acetabular center coordinates of each pixel coordinate are acquired based on the acetabular region of interest, the screening area of the acetabular cup is determined based on the acetabular center coordinates and the received screening conditions, the Hounsfield unit value corresponding to each pixel coordinate is processed based on a preset dynamic threshold method, and the cortical bone Hounsfield unit average value and the cancellous bone Hounsfield unit average value of the screening area are obtained; prediction analysis is carried out based on the user information and the cortical bone Hounsfield unit average value and the cancellous bone Hounsfield unit average value of the screening area, and a prediction result is generated, so that more objective and accurate acetabular cup stability evaluation can be provided based on the prediction result.