65 results about "Pathologic" patented technology

The present invention discloses a method for segmentation of a breast cancer pathologic image. There are three main modules consisting of data preprocessing, cell nucleus detection and cell nucleus boundary refinement segmentation. Pathology experts perform artificial calibration of a cell nucleus boundary, the pathologic image is subjected to standardization processing to eliminate dying difference, a training sample based on a cell nucleus pixel, and a cell nucleus boundary pixel and a background pixel is made to train a convolutional neural network classifier and achieve a classifier basedon a Patch image center pixel. A trained convolutional neural network model is detected on the whole pathologic image to output a probability graph, a postprocessing algorithm is employed to generatea binary image as an initialized shape outline of an active outline model, and the active outline model is employed to perform refinement segmentation of the cell nucleus boundary. The method and thedevice for segmentation of the breast cancer pathologic image are high in segmentation accuracy, and can achieve the algorithm for segmentation of overlapped cells in the breast cancer pathologic image. The present invention further discloses a device for segmentation of a breast cancer pathologic image.

A drug-eluting stent is disclosed; together with various methods for treating atherosclerotic plaques and other cardiovascular diseases via intervention on vasa vasorum.

A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectral range of 360 to 750 nm). Combining LIF and white light responses, as well as evaluating a spatial correlation between proximate cervical tissue sites in conjunction with a statistically significant “distance” algorithm, such as the Mahalanobis distance between data sets, can improve the discrimination between normal and abnormal tissue. The results may be displayed in the form of a map of the cervix representing the suspected pathology.

The present invention relates to compounds for treatment that protects the endothelium, prevent pathologic thrombus formation in the microcirculation and preserve platelet number and function and thus may be related to minimizing or preventing development of organ failure, including multiple organ failure (MOF), and, hence, death in critically ill patients by administration of agent(s) limiting the platelets ability to aggregate and form clots and / or by agents modulating / preserving endothelial integrity and / or by agent(s) increasing the rate of thrombus lysis, and Another aspect of the invention related to by a cell-based whole blood viscoelastical haemostatic assay identifying critically ill patients at increased risk of development of organ failure, including multiple organ failure (MOF) and death.

A system and method of providing information concerning pathological findings evidenced by radiographical reports. A medical care provider may request a radiographical image, in particular, an MRI image of a region of the body. The region of the patient's body is scanned and the images are read and interpreted to determine if there is a positive finding of a pathology. If a pathology is detected, the generated scanned images are reviewed for a radiographical image that best depicts the detected pathology and the image is selected for further annotation. The image is then annotated to highlight and more fully describe and delineate the pathology thus alerting the medical care provider of the pathology's existence. In addition, the report may be further delineated with an identifying mark informing the referring physician of a positive finding of a pathology.

The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.

A method for synthesizing electrocardiogram leads includes obtaining a sequence of voltage-time measurements for a set of electrocardiogram leads and subjecting the measurements to abstract factor analysis to obtain a set of eigenvalues and associated eigenvectors. A minimal subset of electrocardiogram leads is identified from which the voltage-time measurements can be calculated with acceptable error. Simplex optimization is performed on a subset of the voltage-time measurements measured with the minimal subset of electrocardiogram leads to obtain a universal transformation matrix, and the universal transformation matrix is multiplied by the subset of the voltage-time measurements to calculate the full set of voltage-time measurements. The full set of leads can be used to calculate a body surface map, and the eigenvalues can be tracked in time to predict the onset of pathology such as myocardial infarction.

It is now recognized that chronic inflammation is an important risk factor for the development of cancer. The proinflammatory cytokine IL-6 is implicated in cancer because it is important for the activation of STAT, a key regulator of cancer growth, survival, metastasis, immune evasion and angiogenesis. Increased IL-6 and Stat-3 exists in vitro in pancreatic cancer, malignant melanoma, papillary thyroid cancer, breast cancer, colon cancer, and prostate cancer cells with high basal expression of Toll-like receptor 3 (TLR3) and Wnt5a. IL6 / STAT3 activation, mediated by overexpressed TLR3 signaling, appears important in the tumor growth process, it may increase Wnt5a signaling, and be associated with increased cellular growth and migration. Using a novel inhibitor of pathologic TLR3 signaling (5-phenylmethimazole [C10]) we have demonstrated decreases in these markers plus suppression of cell growth and migration in human pancreatic cancer, malignant melanoma, papillary thyroid cancer, breast cancer, colon cancer, and prostate cancer cells.

The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.

Method and system embodiments of the present invention employ computational analysis tools running on one or more computer systems to quantitatively analyze MRI data from patients in order to both assess various functional parameters and characteristics of a patient's kidney, as well as to provide an electronic display device interconnected with the one or more computer systems, and accessible visualization of the quantitative assessment to facilitate diagnosis of various types of kidney abnormalities and pathologies.

Methods for reducing the number of pathologic antibody producing B cells in a patient suffering from an autoimmune disease by administration of an anti-germline antibody are described. Methods for removing pathologic antibodies and B cells and plasma cells producing pathologic antibodies from the body of a patient suffering from autoimmune disease are provided, comprising contacting the blood or plasma of the patient with an immunoadsorbent having specific binding for an epitope present on germline antibodies, particularly VH4-34 antibodies, wherein said contacting results in the reduction in the amount of germline antibodies present in the blood or bone marrow or lymphoid tissue of the patient or the amount of germline antibody producing B cells present in the blood, lymphoid tissues or bone marrow of the patient. Methods for treating a patient suffering from a B cell cancer expressing cell surface germline antibodies by similar methods are also provided. Methods for ex vivo purging bone marrow of pathologic antibody producing B-cells and cancerous B-cells expressing germline antibodies are provided. Methods for monitoring the efficacy of a therapeutic treatment in a patient suffering from an autoimmune disease or B cell cancer are also provided. Kits and uses in preparation of a medicament are also described.

The invention belongs to the technical field of medicines and in particular discloses a compound shown as a formula I or a formula II. Each symbol is defined as claims. The compound shown as the formula I or the formula II, provided by the invention, can be used as an IDO (Indoleamine-2,3-dioxygenase) regulator; the invention specifically discloses application of the compound to preparation of a medicine for treating IDO-mediated diseases with tryptophan metabolic pathway pathologic features. The formula I and the formula II are shown in the description.

An in vitro chamber for mimicking the mechanical and electrical forces found in vivo under physiological or pathological state. A chamber provides conditioning stimuli. The conditioning stimuli replicate a pathology, including the ability to replicate a diseased pathology. The chamber is configured to allow the additional stimuli to test physical, chemical or electrical stimuli impact on cells experiencing the particular pathology. Pharmaceuticals may be tested ex-vivo on cells exhibiting a pathology in an environment mimicking the in-vitro environment. Physical components such as pacemakers may also be tested on such cells in the chamber.

The invention provides a remote pathologic diagnosis section digital image processing method, belonging to the technical field of medical image processing. The method comprises following steps that acquired section specimens are processed according to a preset strategy, and then to-be-processed sections are generated; a section scanning terminal scans the to-be-processed sections so as to acquire digital pathologic section images, determines corresponding transmission priorities, and sends the digital pathologic section images to a server according to the transmission priorities; the server performs hierarchical processing on the acquired digital pathologic section images and stores a hierarchical processing result; and the server receives section image acquisition requests from all client sides, and then pushes a section image corresponding to an image hierarchical range to a corresponding client side according to a preset push strategy. Through adoption of the method, important digital pathologic section images are guaranteed to have the priority to transmit, furthermore, a corresponding hierarchy of section image is pushed to a corresponding client side, so that the user experience is greatly improved.

A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.

The invention relates to the field of biotechnology and particularly relates to a method for establishing an Alzheimer disease pathologic model based on the transgenic technology. In the invention, the Alzheimer disease pathologic model is established by generally over-expressing an HO-1 (heme oxygenase-1) gene in a mouse by using the transgenic technology. The transgenic mouse automatically forms the Alzheimer disease tau pathology, which is an ideal animal model for researching the generation mechanism of neurofibrillary tangles as a typical pathologic symbol of Alzheimer disease.

Provided herein is an immunogenic composition comprising a synthetic consensus FAP antigen. Also disclosed herein is a method of treating or preventing a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.

The present invention encompasses a compound of Formula (I) useful as caspase active site probes. These probes can be used to determine whether a caspase has been activated, in cells or in tissues of animal models of various pathologies. Furthermore, through competition based assays, these caspase active site probes can be used to calculate the percentage of occupancy of active caspases by other, unlabeled inhibitors.

The invention relates to the graded expression level of SNAIL gene or its expression products, as a marker of the capacity of epithelial and mesenchymal tumours and / or cancers for disseminating to other tissues or organs. The invention further relates to a transgenic non-human mammal comprising in its genome a transgene that comprises a nucleic acid sequence encoding the SNAIL protein, and the use of SNAIL as a marker of epithelial and mesenchymal tumours and / or cancers as well as in DNA damage-based diseases In addition, the invention relates to the use of SNAIL as a therapeutic and diagnostic target for said pathologies.

The invention relates to a digital pathologic imaging device, and belongs to the technical field of optical imaging. The digital pathologic imaging device comprises a microscopic illumination device, a microscopic object lens and a digital image sensor; the microscopic illumination device comprises a light source, a Mie scattering device, an optical cavity and a condenser; the light source is positioned in one side of the Mie scattering device, the condenser is positioned in the other side of the Mie scattering device, and the light source emits light to irradiate the Mie scattering device; the Mie scattering device is used to scatter and radiate the light from the light source onto the condenser; the condenser focuses and outputs the light input from the Mie scattering device to a tested object; the microscopic illumination device comprises first and second lenses arranged along the optical axis direction, and the first lens is used to receive light from the tested object; the front surface of the first lens and the back surface of the second lens are plated with semi-transmitting semi-reflecting optical dielectric light splitting films respectively; and the digital image sensor receives light from the second lens and carries out digital imaging.

Disclosed is a lyceum barbarum polysaccharide-containing protective liquid and an application method thereof for enhancing adaption of mesenchymal stem cells to in vivo pathologic microenvironment. The method comprises the steps of separation, culture and identification of the mesenchymal stem cells, application function evaluation and composition of the lyceum barbarum polysaccharide-containing protective liquid, mechanism of action of the lyceum barbarum polysaccharide-containing protective liquid and the like. The natural herb extract of lyceum barbarum polysaccharides serve as the major component to replace existing methods such as gene editing and chemical treatment, namely, the purely natural herb extract is applied to intervening the mesenchymal stem cells to enable the mesenchymalstem cells to better adapt to the complex in vivo pathologic microenvironment and to improve the survival ability and the therapeutic potential. The lyceum barbarum polysaccharide-containing protective liquid can significantly improve the survival rate of the mesenchymal stem sells in the in vivo pathologic microenvironment.

The invention relates to a multipurpose pathologic biopsy specimen box convenient to use. The multipurpose pathologic biopsy specimen box is composed of a box body, specimen bottles, bottle caps and a label paper slot. The box body is provided with the specimen bottles in two parallel rows, serial numbers are arranged on the areas, corresponding to the specimen bottles, on the box body. The label paper slot is formed in the box body. Replaceable label paper can be placed in the label paper slot and contains a patient information table and an organ tissue diagrammatic drawing. The bottle caps can cover the specimen bottles. Each specimen bottle is composed of a bottle body, an inner container and a scraper, wherein the scraper is located on the inner wall of the inner container, and the inner container can be placed in the bottle body. The multipurpose pathologic biopsy specimen box has the advantages that the multipurpose pathologic biopsy specimen box is integrally designed so as to facilitate clinic usage and specimen conveying; the bottle cap design is reasonable, so that the tedious step that the bottle caps are opened one by one is simplified; due to the slot designed between the two rows of specimen boxes and the scrapers arranged in the specimen bottles, the multipurpose pathologic biopsy specimen box is quite convenient to use and worthy of popularization.

A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.

A multifunctional medical pathologic sampling workbench apparatus comprises an upper cabinet, a lower cabinet, a workbench top, a collection air hood, air supply, air suction, electro-crushing, and ozone negative ion purifying devices, LED lights, a universal shadowless projector, an ultraviolet sterilizing lamp, a digital imaging device, a basin, a faucet, a chopping board, a lifting system, and a control circuit; the top cabinet, the lower cabinet and the workbench top are integrated, the air supply device, the LED lights, the universal shadowless projector and the ultraviolet sterilizing lamp are mounted in the top end of the upper cabinet, the collection air hood and the air suction device are mounted in the lower front of the upper cabinet, the digital imaging device is mounted at the right of the upper cabinet, the basin and the faucet are mounted on the upper left of the workbench top, the ozone negative ion purifying device is mounted in the lower cabinet, the lifting system is mounted at the lower portion of the lower cabinet, and the control circuit is in wire connection with the air supply device, the air suction device, the electro-crushing device, the ozone negative ion purifying device, the LED lights, the universal shadowless lamp, the ultraviolet sterilizing lamp and the digital imaging device. The multifunctional medical pathologic sampling workbench apparatus facilitates pathologic sampling.

The invention discloses a pathologic sampling and preserving device. The pathologic sampling and preserving device comprises an operation platform, a material inlet, a material outlet, an imaging mechanism and a simulation operation mechanism, wherein the material inlet and the material outlet are formed in an operation bin in front of the operation platform, the imaging mechanism is arranged in the operation bin, and the simulation operation mechanism is arranged in back of the operation platform. The imaging mechanism is composed of a plurality of high-definition cameras arranged on the inner wall of the operation bin, and the high-definition cameras feed information back to the simulation operation mechanism. With the structural form of the pathologic sampling and preserving device, operation safety can be improved, and it can be avoided that an operator stretches the hands into the device for cutting, the hands are scratched, and the probability of infection is increased; meanwhile, for overcoming the defect that a sealing protection effect can not be achieved in an existing preservation mode, the device is designed, patients or other persons can not open the device, the strictness of pathologic material preservation and transport is protected, and the device is worthy of application and popularization.

The invention relates to a novel pathologic biopsy specimen bottle liner. The specimen bottle liner is constituted of a cup body, a scraper, a thin film and a pathologic specimen stationary liquid, wherein the cup body is shaped like a cylinder, the pathologic specimen stationary liquid is filled inside the cup body, the scraper is disposed on the inner wall of the cup body, one end of the scraper which is not contacted with the cup body inner wall is a tip end, height of the scraper is lower than the height of the pathologic specimen stationary liquid, and the upper opening of the cup body is sealed by the thin film. The novel pathologic biopsy specimen bottle liner is advantageous in that the novel pathologic biopsy specimen bottle liner provided by the invention is designed in an integral manner and used for one time and the upper opening of the liner is sealed by the thin film, so that a working staff can use the liner very conveniently, and does not need to clean a specimen bottle, labor capacity of the working staff is relieved, and medical waste can be managed conveniently. The novel pathologic biopsy specimen bottle liner has a simple structure and is manufactured easily. In addition, the scraper is disposed on the inner wall of the liner, so that a specimen on a puncture needle can be very conveniently scraped into the pathologic specimen stationary liquid.

Provided are compositions of compounds effective for treating a pathology, the composition comprising at least two compounds that modulate the activity of one or more target molecules associated with one or more Single Nucleotide Polymorphisms (SNPs). Methods are also provided for increasing overall treatment efficacy for a population of patients having a pathology.

The invention relates to the technical field of gene knockout, in particular to a method for knocking out a zebrafish slc26a4 gene. Through a CRISPR / Cas9 gene editing technology, a proper targeting site is designed on a zebrafish slc26a4 gene, and specific sgRNA and Cas9-mRNA are synthesized in vitro for gene editing of zebra fish. The invention can more efficiently and more accurately silence specific genes, is simple to manufacture and low in cost, can simultaneously shear multiple sites on a target gene and silence any number of single genes, and also provides a method for breeding slc26a4gene deletion type zebrafish through gene knockout, a zebrafish model is constructed by the method. The method is helpful for further revealing the whole process of human large vestibular aqueduct syndrome and a molecular mechanism for regulating the process, and has very important significance in understanding the pathology of vestibular aqueduct and researching and developing a new treatment scheme in medicine.