73 results about "Clinical exam" patented technology

An improved method and products for the primary hormonal treatment of early stage, low and intermediate risk prostate cancers by prostatic implants of androgen suppressive drugs formulated as fused with a lipoid carrier or encapsulated in microcapsules or in Silastic capsules is provided. Such prostatic implants renders a constant slow-release of their contents to the prostate for extended periods by biodegradation and diffusion. It facilitates higher prostatic and lower systemic concentrations of androgen suppressive hormones. Because of their high prostatic and lower systemic concentrations, tumor control is much improved and the their systemic toxicity is minimized. Tumor control after such primary hormonal implant treatment is followed by clinical examinations and the biochemical tumor control is followed by periodic estimations of serum levels of PSA and acid phosphatase. More complex and expensive surgery or radiation therapy for this group of good prognostic early stage prostate cancer is reserved for those patients failing to this primary hormonal treatment. It will preserve potency more than by surgery or radiation therapy. Furthermore, it would reduce the cost of treatment for early stage prostate cancer significantly. Androgen suppressive hormonal implants to the prostate before, during or after lower dose conventional radiation therapy would also facilitate equal or better cure rates of localized prostate cancer as compared to the more complex and toxic higher dose radiation therapy.

The present invention is an automated image analysis framework for cervical cancerous lesion detection. The present invention uses domain-specific diagnostic features in a probabilistic manner using conditional random fields. In addition, the present invention discloses a novel window-based performance assessment scheme for two-dimensional image analysis, which addresses the intrinsic problem of image misalignment. As a domain-specific anatomical feature, image regions corresponding to different tissue types are extracted from cervical images taken before and after the application of acetic acid during a clinical exam. The unique optical properties of each tissue type and the diagnostic relationships between neighboring regions are incorporated in the conditional random field model. The output provides information about both the tissue severity and the location of cancerous tissue in an image.

According to various embodiments, a hierarchical health decision support system (HDSS) configured to receive data from one or more wearable medical sensors (WMSs) is disclosed. The system includes a clinical decision support system, which includes a diagnosis engine configured to generate diagnostic suggestions based on the data received from the WMSs. The HDSS is configured with a plurality of tiers to sequentially model general healthcare from daily health monitoring, initial clinical checkup, detailed clinical examination, and postdiagnostic treatment.

The present invention relates to a clinical laboratory test apparatus capable of simply and quickly attaching and detaching a microchip. The clinical laboratory testing apparatus comprises a microchip having a measuring cell that holds a sample liquid; a rotation body; a rotation drive mechanism that rotates the rotation body; a lock mechanism that locks the microchip on the rotation body; a measurement room that holds the microchip and the rotation body and that has an attachment and detachment opening; a protection cover that closes the attachment and detachment opening; a light source that irradiates the measuring cell; and a light receiving unit that receives the light, wherein a centrifugal separation processing of a specimen in the sample liquid is performed in the microchip by the rotation drive mechanism rotating the rotation body, and wherein the protection cover has a pressing-down member that presses down a wall face of the microchip when the protection cover is closing the attachment and detachment opening.

Provided is a clinical laboratory apparatus comprising a pretreatment device by which multiple items of multiple specimens can be simultaneously treated in parallel and various irregular clinical examination needs can be appropriately satisfied and which enables highly efficient separation and exhibits high reproducibility and high reliability. Also provided is a mass spectrometer which comprises the pretreatment device combined with a mass spectrometer and by which a process from pretreatment to detection can be fully automatically performed. A pretreatment device comprising: a cartridge which can hold a packing for solid extraction; a pressure-applying part which applies pressure to the cartridge for solid extraction; a receiving tray mechanism which receives a sample extracted from the cartridge; and a liquid level sensor which detects the liquid level in the cartridge and the receiving tray. When the liquid level sensor detects the attainment of the liquid level in the receiving tray mechanism to a preset position, a signal is fed back so that a pressure release valve in the pressure-applying part is opened.

[PROBLEMS] To provide lipase activity determination reagents which function by an enzymatic method. The reagents are easy to use in an ordinary clinical examination, have excellent handleability, and are excellent in accuracy and reproducibility. [MEANS FOR SOLVING PROBLEMS] Lipase activity is determined with any of reagents which comprise a low-concentration buffer and a diglyceride dissolved therein. The diglyceride is used as a substrate for lipase, whereby the liquid reagents can have long-term storage stability. One of the reagents converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, pyruvate kinase, lactate dehydrogenase, reduced NAD, ATP, and phosphoenol pyruvate. Another reagent converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, glucose, ADP-dependent hexokinase, glucose-6-phosphate dehydrogenase, oxidized NAD or oxidized NADP, and ATP. A further reagent converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, glycerol-3-phosphate oxidase, peroxidase, and a dye which colors in the presence of hydrogen peroxide.

This invention describes new protocols for screening for cervical carcinomas or high-grade premalignant cervical lesions based on combinations of testing for the presence of high-risk HPV, HPV genotyping, marker analysis, and / or cytology. With these protocols the number of women that have to undergo follow-updiagnostic testing and / or clinical examinations will decrease. Further, the number of false positives and false negatives will decrease.

Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline phosphatase, creatine kinase and alanine aminotransferase; (b) a stabilizer component comprising effective stabilizing amounts of an albumin, and at least one saccharide selected from the group consisting of trehalose and sorbitol; and (c) an aqueous medium having dissolved therein the components (a) and (b). The enzyme composition of the present invention is stable for a prolonged period of time not only under non-freeze refrigeration conditions, but also under freezing conditions or under conditions for non-freeze refrigeration after thawing of the frozen composition, as compared to the conventional enzymatic compositions. The enzyme composition of the present invention can be advantageously used for the purpose of checking the precision in measurement, correcting measured values and calibrating the amount and activity of an enzyme, in a clinical examination for measuring the enzymatic activity in a sample, such as serum or the like.

The invention discloses a health evaluation objective structuralized clinical exam system and an operation method thereof. The health evaluation objective structuralized clinical exam system comprises a basic data module, an on-site exam module and a subsequent summarizing and analyzing module. The basic data module comprises student basic conditions, exam testing contents and exam rules and requirements, the on-site exam module mainly comprises a detailed exam list generated randomly according to preset requirements, contents of five major exam stations are designed as five projects in on-site exam module according to the mode of objective structuralized exam for health evaluation, and the subsequent summarizing and analyzing module mainly performs statistical analysis of overall exam and each of detailed projects of students according to class and grade and presents the same by visual forms such as diagrams. The health evaluation objective structuralized clinical exam system and the operation method thereof integrate examinees, exam station information and real-time exam results, automatically generate exam schedules and rating scales of the examinees and extract evaluation modules randomly by a computer, and examiners score in the rating scales in different pre-designed modules in real time, so that the exam can be realized fairly, equally and rapidly.

The invention relates to an auxiliary laboratory diagnosis method for some hereditary diseases caused by X chromosome FMR1 (fragile X mental retardation 1) gene abnormity. The method is established aiming to improve the accuracy of clinical diagnosis by using a molecular biological detection method as an auxiliary means for clinical examination, and to provide a new detection means for prenatal screening for related hereditary diseases.

The invention discloses a convenient-to-use film viewer for clinical examination of tumors. The film viewer comprises a box body and a film viewer body. A piston rod of a first electric telescopic rodmounted in the lower cavity is connected to the bottom of the lifting seat. The film viewer body is movably connected to the first connecting base through rotating shafts on the two sides of the bottom of the film viewer body. A piston rod of the second electric telescopic rod is movably connected to a second connecting seat at the front part of the lower end of the film viewer body through a pinshaft, the screw rod is driven by a motor at the right end of the bracket at the lower part, the right side of the vertical sleeve is connected with a magnifying lens, and the left side of the vertical polish rod is connected with a vertical brush. The height and the opening angle of the film viewer body can be adjusted, clinical use is facilitated, and the magnifying lens moves in the up-down direction and the left-right direction, and a film can be conveniently viewed through the magnifying lens. Finally, the film viewer body can be completely stored after being used, so that the film viewer body can be protected, and the space is saved.

A novel terthiophene-3-carboxylic acid compound is disclosed that a functionalized conductive terthiophene polymer having carboxylic groups produced in an electrochemical method using the compound as a monomer and a novel process for detecting DNA hybridization through impedance measurement using the polymer. In addition, a method for manufacturing a probe DNA used in the process for detecting DNA hybridization is provided. Since the process can detect DNA hybridization using impedance change, without the use of any indicator, small-sized sensor systems which measure impedance in a particular frequency range can be fabricated. The systems are applicable to portable sensors for identifying DNA sequence hybridization for clinical examination and disease diagnosis. Further, the process has an excellent selectivity of complementary sequences to mismatched sequences.

The present invention discloses an abdomen percussion device for clinical examination in internal medicine department. The abdomen percussion device comprises a placement plate, a motor is arranged onan upper surface of the placement plate, a fixing rod is fixedly connected to an output end of the motor, a disk is fixedly connected to one end of the fixing rod, a fixing block is fixedly connectedto one side of the disk, a first rod body is fixedly connected to a lower surface of the fixing block, a first L-shaped plate is welded to a lower surface of the placement plate, a first plate body is welded to one side of the first L-shaped plate, a second limiting sliding groove is formed in one side of the first plate body, a first limiting sliding block is slidably connected to an inner sidewall of the second limiting sliding groove, through a combined arrangement of a first threaded rod, a third plate body, a first limiting sliding groove, a second limiting sliding block and other components, the abdomen percussion device can be conveniently fixed and adjusted, meanwhile, abdomen sizes and percussion positions of different patients can be conveniently adjusted, diagnosis results ofabdomen percussion are more accurate, operation is easy, and medical staff can use the abdomen percussion device conveniently.

The invention provides a pediatric clinical special examination device, and relates to the field of medical equipment. The pediatric clinical special examination device comprises a bed plate, a connecting rod and a sliding block, wherein a mounting plate is arranged at the bottom of the left side of the bed plate; a fastening bolt is arranged in the mounting plate and fixedly connected with the bed plate; the connecting rod is fixedly connected to the left side of the mounting plate; the connecting rod is vertically upward; an examination box is fixedly connected to the side, close to the bedplate, of the top of the connecting rod; the two sides of the bed plate are each fixedly connected with a covered edge; a plurality of open grooves are formed in each covered edge; the open grooves vertically penetrate through the covered edges; a clamping groove is formed in the inner side of each open groove; a rotating shaft is arranged in each clamping groove; a guide rail is arranged at the top of the bed plate on the inner side of each covered edge; and two sliding blocks are slidably connected in each guide rail. The sliding blocks move in the guide rails, the positions of elastic bandsare adjusted, children of different ages are fixed, and therefore doctors can conveniently conduct clinical examination on the children.

The invention discloses a rehabilitation system for an elderly patient with senile hypertension and cerebral stroke, which comprises the following modules: A, a target population confirmation module:distinguishing and screening target populations, and defining all objects as cerebral stroke patients through clinical examination to obtain required target populations; B, a feature construction module for correspondingly grouping and integrating the target crowd and recording the current health data. Risks of complications are reduced and the application effect of the Barthel index-based evaluation scale in rehabilitation nursing of middle-aged and elderly patients with hypertension with cerebral apoplexy under the general idea is obvious; the system can effectively adjust the blood pressurelevel of a patient, control the blood pressure to be stable, reduce the recurrence risk of cerebral apoplexy, ensure the continuity of treatment and rehabilitation nursing of the patient, improve thecompliance of treatment and rehabilitation training of the patient, help the patient to form a good self-management habit, relieve negative emotion and accelerate recovery of the patient.

The invention relating to the technical field of clinical examination discloses lighting equipment for gynecological clinical examination, thereby solving a problem that the installation position of an illuminating lamp in an existing inspection room is fixed and thus the illumination direction and angle are inconvenient to adjust. The lighting equipment comprises a supporting rod; a bearing is fixedly arranged outside the supporting rod in a sleeving manner; the outer ring of the bearing is fixedly connected with a fixed rod; a piston is welded to the end, away from the bearing, of the fixedrod. A sleeve is movably arranged outside the piston in a sleeving manner; a clamping plate is welded to the end, away from the bearing, of the sleeve; a gear disc is rotatably connected to the interior of a clamping plate; an illuminating lamp is fixedly connected to the gear disc; a horizontally-arranged first push rod motor is fixedly connected to the outer wall of the top of the sleeve; and afirst rack is fixedly connected to the tail end of an output shaft of the first push rod motor. According to the device, the illumination angle can be adjusted, and the direction can be adjusted, so that better examination by medical staff is facilitated, and the practicability of the device is improved.

The invention provides a bronchoscope simulation system based on personalized data. The system comprises a control handle which is used for receiving the operation of a user for simulating a bronchoscope, a display used for displaying a graphical interface interacting with a user, a memory used for storing data and application programs, and a processor which is used for running the application program in the memory so as to execute the following steps: a three-dimensional reconstruction step: generating an interactive three-dimensional digital bronchial tree; a focus prediction step: performing prediction analysis on the characteristics of the focus according to the characteristics of the focus so as to create a training case based on personalized data; and a simulation probing step: drawing an image of the training case on the graphical interface, and drawing an under-mirror image according to the received input of the user through the control handle, and completing the simulation probing operation. According to the invention, repeated drilling can be carried out based on individual data of the patient before clinical examination, the technical proficiency and accuracy of a trained doctor are improved, and the efficiency and safety of a bronchoscope of the patient are improved.

The invention discloses a patient-centered clinical examination appointment system clinical examination appointment system taking a patient as a center. The system comprises a client and an appointment server, centralized appointment is carried out through the appointment server, and patient-centered automatic appointment with a patient as the center is achieved. The reservation server comprises an information transceiving module, a pre-queuing module and an optimization processing module. Concentration of detection and inspection time and optimization of inspection and inspection sites are realized by taking a patient as a center, and the number of times of going back and forth to hospitals of the patient and the distance of going back and forth in the hospitals are reduced to the greatest extent. The invention further discloses a patient-centered clinical examination appointment method.clinical examination appointment method with the patient as the center.

The invention discloses a novel B-ultrasonic examination device and a using method thereof, and relates to the technical field of medical facilities. The novel B-ultrasonic examination device comprises a B-ultrasonic machine, wherein an examination bed assembly is arranged on one side of the B-ultrasonic machine; the examination bed assembly comprises a base, and a group of fixed seats which are distributed in a rectangular array are fixedly connected to the bottom surface of the base; a threaded screw rod is rotationally connected between the opposite surfaces of every two fixed seats; a conical tooth ring is fixedly connected to the peripheral side surface of each of the two threaded screw rods; an annular seat is fixedly connected to the bottom surface of the base; a connecting rod is rotationally connected to the inner wall of the annular seat; and bevel gears are fixedly connected to two ends of the connecting rod. Through the design of the base, a supporting seat, electric telescopic rods, an upper supporting plate and a lower supporting plate, the problems that in the using process of an existing B-ultrasonic examination device, an examination bed cannot meet different clinical examination requirements easily, so that the examination efficiency of the device is low, an examinee feels much uncomfortable in the examination process, and further the practicability of the device is poor can be solved.

The clinical examination device comprises a base, a mounting block is arranged at the upper end of the base, a cylindrical groove is formed in the left side of the mounting block, an electric telescopic rod is arranged on the inner wall of the right side of the cylindrical groove, and the telescopic end of the electric telescopic rod is fixedly connected with a moving block; the left side of the moving block is fixedly connected with a connecting rod, the right end of the connecting rod is fixedly connected with a camera, the right side of the mounting block is rotatably connected with a rotating rod, the right end of the rotating rod is fixedly connected with a rotating handle, and the left end of the rotating rod extends into the cylindrical groove and is fixedly connected with the right side of an electric telescopic rod. According to the device, during camera detection every time, intermittent airflow can be blown to the head of a patient by rotating a handle, the anxiety feeling of the patient is relieved, meanwhile, automatic disinfection can be conducted after diagnosis every time, volatilization of alcohol on the surface of the camera is accelerated through hot airflow after disinfection is completed, and therefore use of the device next time is facilitated.

The invention relates to the technical field of medical instruments, and in particular to a tongue pressing and scraping dual-purpose device for pediatric clinical examinations. The device comprises atongue pressing plate and a handle fixedly connected with the tongue pressing plate; the tongue pressing plate is provided with a groove for placing a tongue scraping plate; one end of the tongue scraping plate is connected with an adjusting assembly arranged in a transmission cavity on the tongue pressing plate; the adjusting assembly drives the tongue scraping plate to stretch and retract rotationally; the tongue scraping plate is rotatably arranged on a mounting plate; and the mounting plate is detachably connected with the tongue pressing plate through a clamping pin assembly arranged onthe mounting plate. The device provided by the invention is novel in design, the tongue scraping plate is rotatably connected with the mounting plate, and the mounting plate can be connected with thetongue pressing plate through the clamping pin assembly, so that the tongue scraping plate is convenient to disassemble and clean, and the sanitation degree is high. The whole device is simple in structure, and the tongue pressing plate and the tongue scraping device are combined together, so that space can be effectively saved, the device is convenient to take and store, and use convenience of medical staff can be improved.

The invention discloses a clinical examination pipeline imbedding auxiliary system, and belongs to the field of clinical examination equipment. The clinical examination pipeline imbedding auxiliary system comprises an auxiliary system main body (1), the head of the auxiliary system main body (1) is provided with a head detection unit (2) and a steering unit (3), and the tail of the auxiliary system main body (1) is provided with a tail feedback display unit (4). The head detection unit (2) is electrically connected with the steering unit (3) and the tail feedback display unit (4) respectively; the operation is simple and easy to master; the auxiliary system can automatically guide the pipeline to be placed into a target part in the body of a patient, the pain of the patient is relieved, the working difficulty of medical staff is reduced, and time is saved; for nasogastric tube placement, the accuracy of the gastric tube placement position is effectively ensured through dual judgment of AI visual identification and pH value detection; the system is simple in structure, no other complex large instruments are needed in the operation process, medical staff can operate the system in any environment, and the applicability is high.

The invention belongs to the technical field of clinical examination, and especially discloses a novel gynecological clinical examination device. An existing gynecological clinical examination deviceis relatively fixed, mainly realizes angle adjustment by turning over a patient and causes difficulty to some weak patients. To overcome the above problems, the novel gynecological clinical examination device in a scheme of the invention comprises a bottom plate, wherein the four corners of the inner bottom wall of the bottom plate are each rotationally connected with a threaded cylinder; a screwrod is arranged in each of the four threaded cylinders in a threaded connection and sleeving manner; the tops of the four screw rods are hinged with the same bed board; and first bevel gears are fixedly arranged on the four threaded cylinders in a sleeving manner. According to the invention, a second rolling shaft can be driven to rotate by rotating a rocker, a fourth bevel gear on the second rolling shaft can rotate a first rolling shaft through a third bevel gear, a second bevel gear on a first rolling shaft can rotate the two threaded cylinders on the same side through the first bevel gears, then the bed board is pushed to incline through the screw rods, and a patient can turn over and conduct adjustment conveniently.

The invention discloses a detection method for children immune thrombocytopenia, and particularly relates to the field of thrombocytopenia detection methods. The method comprises the following specific detection steps: S1, establishing a multi-center child ITP research cooperation group; S2, standardizing ITP clinical examination diagnosis and chronic prejudgment standards of children; S3, formulating and implementing an advanced ITP precise layering treatment scheme: evaluating a plurality of newly diagnosed ITP child patients entering the group according to the scheme; S4, performing follow-up visit and statistical analysis; and S5, performing multi-center random control clinical test. According to the invention, a child ITP diagnosis and treatment research cooperation group is established, a core expert group is established to manage the cooperation group, a unified and standard diagnosis and treatment scheme is implemented, a child ITP diagnosis and treatment research network withcooperative access and rapid response is formed, and the child ITP diagnosis and treatment research network is radiated downwards to primary hospitals by taking member hospitals as backbones; throughscientific research and innovation, key clinical problems existing in current ITP treatment are promoted to be solved, and the overall diagnosis and treatment level of children ITP in China is greatlyimproved.

An intelligent percussion hammer disclosed by the present invention comprises a percussion hammer, an electronic control device and a power supply system, a percussion rubber head is installed on a percussion support, and the electronic control device comprises a pressure sensor, a pressure sensor module, a control module, a liquid crystal display, a voice module and a loudspeaker. The pressure sensor is installed on the inner side of the percussion rubber head on one side, the control module, the liquid crystal display, the voice module and the loudspeaker are installed on the inner side of the percussion support, and the power supply system comprises a DC 5-12 V lithium battery, a switch and a charging socket. The DC5-12V lithium battery is respectively connected with the pressure sensor, the pressure sensor module, the control module, the liquid crystal display and the voice module. According to the principle of the percussion hammer, the percussion force of the percussion hammer is objectively displayed, so that a clinician finds out the optimal percussion force of the percussion hammer in continuous clinical examination practices, neuromuscular reflex appears accurately and timely, and various diseases are accurately diagnosed.

An ELISpot diagnosis kit for NMO and its application are characterized in that, the polypeptide fragment specific to NMO effector T-cell is obtained through topological conformation analysis of aquaporin-4 (AQP-4), followed by the structural analyses of the related polypeptides after combination and rearrangement so as to screen out the brand-new polypeptide fragment suitable for NMO disease diagnosis. In the ELISpot experiment, by utilizing the obtained polypeptide fragment, stimulate the effector T-cell in the NMO disease to secrete IL-4, proving the feasibility and scientific value of that polypeptide fragment in the NMO diagnosis. This method is with strong specificity, high sensitivity and easy operations, and it can be developed into the diagnosis kit for the diagnosis and differential diagnosis of NMO in the clinical examination, laying the foundation for the early discovery and treatment of NMO.