88 results about "Radiation therapy" patented technology

The present invention relates to MSLN-specific binding constructs comprising a designed ankyrin repeat domain with binding specificity for MSLN and a chelator capable of bonding to a radionuclide, as well as to such MSLN-specific binding constructs comprising a half-life extending moiety with binding specificity for serum albumin. The invention further relates to methods of producing such radio-labelled MSLN-specific binding constructs, pharmaceutical compositions comprising such constructs, and the use of such constructs or pharmaceutical compositions in methods for treating, imaging or diagnosing diseases, such as cancer.

A linear accelerator for a radiation therapy system includes a plurality of cavities aligned along a length of the linac and a channel extending between adjacent cavities of the plurality of cavities. The plurality of cavities include a first material and the channel includes a second material different from the first material.

The invention provides a therapy apparatus and a radiation therapy apparatus capable of reducing the limitation on the movement range of a therapy table while suppressing the area of a therapy room. The movable door (70) slides to the left side in the transverse direction (D1) relative to the irradiation opening (55a) during the first sliding, and slides to the right side in the transverse direction (D1) relative to the irradiation opening (55a) during the second sliding. Namely, when the movable door (70) slides towards one side in the transverse direction (D1), the movable door (70) does not exist on the other side, and when the movable door (70) slides towards the other side in the transverse direction (D1), the movable door (70) does not exist on the one side. Therefore, when the treatment table (60) moves close to the wall part (103) (as shown in the states (a) and (b) in Figure 5), the movable door (70) slides to the side opposite to the treatment table (60), so that the space of the treatment table (60) can be ensured. At this time, even if the movable door (70) and the irradiation port (55a) are not excessively spaced apart, interference between the movable door (70) and the treatment table (60) can be suppressed.

The ability to improve the adjusting of technical parameters in therapy plans found by Pareto navigation constitutes a technical problem, along with facilitating the decision-making of the planner (also called user) and simplifying the mathematical calculation of the solution. Proposed is a way to find and establish a therapy plan among a plurality of plan proposals for cancer therapy, each plan proposal representing as a solution one point in a navigation space (N) containing a plurality of setting parameters and establishing in a machine space (M) a setting for radiation doses to be administered by a radiation therapy machine for cancer therapy. The navigation space (N) contains at least one Pareto front (200) behind or on which available treatment plans are located as possible solutions and among which a user navigates, whereby a first plurality of available solutions calculated in advance as plan proposals is provided in a memory and retrieved or read out from the memory for display. The retrieved or read-out plan proposals are shown on a display and used by the user for navigation, whereby a large number of Pareto-optimal solutions with physical values or evaluations of dose values can be found among the points. Moreover, such solutions are also shown that are almost Pareto-optimal, within a tolerance range of at most ±5% from the Pareto optimum. In this way, a large first set of points with the physical values or evaluations of dose values is created and then stored in the memory. From this, a second set of points is calculated, which defines clinical targets. A decision space (D) is provided and shown in which at least the clinical targets are plotted on target axes (76, 876, 776). This is without the possibility of navigating in the decision space (D) on the target axes of the clinical targets, whereas binary selections in the decision space are made in the manner of restrictors to specify which plan proposals are not used as therapy plans. This enables a desired therapy plan to be found and determined from the large number of plan proposals.

The present invention relates to a radiation therapy or microwave therapy or cryosurgery or ultrasound therapy reference positioning marker (5) adapted to be implanted in tissue using a hollow injection needle (4), wherein the marker comprises an elongated object with a longitudinal axis (CL) and have cross-sections (A-A, B-B, C-C, D-D, E-E, F-F) of the object, perpendicular to said longitudinal axis (CL), being adapted to fit within an inner diameter (DI) of the needle (4), wherein the marker (5) comprises a plurality of first segments (1) having a first cross-section and one or more second segments (2) having a second set of cross-sections, wherein an area of the first cross-section is selected relatively larger than area / s of the second set of cross-sections, and wherein the first segments (1) and second segments (2) are arranged alternately after each other along the longitudinal axis (CL), wherein the one or more of second segments (2) are provided with one or more deformation segments (22) adapted to ensure that any deformation of the plurality of second segments, when positioned inside the needle, occurs in a predetermined location / s between adjoining first segments, such that the plurality of first segments remain linearly aligned in the injection needle when it encounters resistance during implantation into the tissue.

The present disclosure relates to methods of treating a tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of a T-cell checkpoint inhibitor in combination with chemotherapy and / or radiation therapy, wherein the subject has reduced levels of CD73 protein or CD73 activity compared to a normal subject. In some embodiments, the method further comprises administering a CD73 inhibitor prior to or concurrently with the combined T-cell checkpoint inhibitor and chemotherapy and / or radiation therapy.

The invention discloses a TCP and multi-NTCP combination optimal dose calculation method and system based on deep learning, relates to the technical field of radiotherapy, and aims to solve the problems of insufficient multi-source data integration, unbalanced multi-organ protection and low individualized precision in traditional dose optimization. The method comprises the following steps: acquiring a CT image of a target patient, a tumor and normal tissue dose-volume histogram (DVH), baseline clinical data and follow-up data after radiotherapy of a patient group; constructing a multi-modal feature data set and an annotation data set through spatial alignment and normalization processing, training a deep learning joint prediction model, synchronously outputting TCP values corresponding to candidate doses and NTCP values of at least three organs at risk, and constructing a fitting curve; and through a single-organ net income formula, a multi-organ comprehensive net income formula and an optimal dose screening formula, quantifying income-risk balance and screening an optimal dose for maximizing the comprehensive net income. According to the invention, through cooperation of deep learning and an exclusive formula system, dynamic quantitative balance of multi-organ unbiased protection and tumor control is realized, individualized precision and clinical landing of radiotherapy dose planning are improved, and the method is suitable for precise radiotherapy scenes of various solid tumors.

Some embodiments relate to imageable radioisotope microspheres. In some embodiments, the imageable microspheres are radiolabeled with an imageable radioisotope. In some embodiments, the imageable radioisotope is directly chemically coupled to the surface of the microsphere matrix. In some embodiments, the imageable microspheres can be used as surrogate particles to predict the distribution of therapeutic microspheres containing radiotherapeutic isotopes.

The present disclosure relates to representation learning for treatment response prediction of risk organs and total tumor volume. For predicting the response of radiation therapy, radiomics is used for unsupervised machine training of an encoder-decoder network to predict based on input of image data, such as computed tomography image data, and from segmentation. Then, the trained encoder is used to generate latent representations to be used as input to different classifiers or regressors for predicting the treatment response, such as one classifier for predicting the response for a risk organ and another classifier for predicting another type of response for a risk organ or predicting the response for a tumor.

The invention relates to a direct drive system for rack rotation. A radiation therapy system comprising: a base secured to or resting on a support surface located outside the radiation therapy system; a rotatable gantry on which a radiation source for delivering therapy is mounted, where the rotatable gantry is rotatably coupled to the base via a bearing; and an electric motor for rotating the rotatable gantry and the portion of the bearing fixed to the gantry. The electric motor includes: a first assembly fixed to a base; and a second assembly fixed to the gantry and separated from the first assembly by an air gap, where magnetic flux through the air gap causes the electric motor to rotate the rotatable gantry and the portion of the bearing fixed to the rotatable gantry.

This application discloses a compound or a pharmaceutically acceptable salt thereof, said compound comprising a compound of formula (I) or a compound of formula (II). A radioactive element preparation comprising thereof and a radioactive element chelated therewith is also disclosed. Its use in the preparation of reagents targeting CXCR4, particularly CXCR4 tracers, more particularly in vivo CXCR4 tracers, or reagents that specifically bind to cells expressing CXCR4 is also disclosed. [Targeting Peptide-I]-Xaa1-X 1 (R 1 )L 1 -[Connector]-R x n1 (I), R x n1 -[Connector]-X 1 (R 1 )L 1 -Xaa1-[targeting peptide-II](II).

The present disclosure provides a radiotherapy plan generation method, comprising: acquiring multi-modal data of a patient, the multi-modal data comprising medical image data and non-image data, the non-image data being text information with medical semantics; inputting the medical image data and the non-image data into a target agent, and determining a cognitive confidence of the target agent for a condition suffered by the patient; determining an execution action according to the cognitive confidence and the non-image data; in response to the execution action being a first execution action, performing segmentation on a tumor target region and / or an organ at risk of the patient based on the medical image data to obtain a segmentation result; and in response to the execution action being a second execution action, generating a radiotherapy plan based on the segmentation result.

A proton cyclotron is provided for dedicated use in head, neck and eye cancers, tumors or other medical conditions including pediatric and other cancers or medical conditions. The method of using a proton cyclotron for treating a tumor, cancer or medical condition of a patient includes positioning the patient on a support platform, such as on a patient table or in a robotic chair, and irradiating the tumor, cancer or other medical condition using a proton particle beam from the cyclotron for a predetermined time sufficient to treat the tumor, cancer or medical condition, wherein the proton particle beam produced by the cyclotron has an energy in a range of 70 MeV to 150 MeV and has a beam current in an amount suitable for radiation therapy, as can include a variable range of beam current for the radiation therapy.

The invention discloses a radiotherapy positioning device and method for tumor radiotherapy, relates to the technical field of radiotherapy positioning, and is used for solving the problem of low treatment efficiency caused by inconvenient operation and low positioning efficiency in the prior art. The bed body is also provided with a thermoplastic film fixing assembly used for fixing the thermoplastic film to a radiotherapy part. A thermoplastic film is attached to the upper portion of a radiation part of the body of a patient, a fixing plate with a pressing air bag and an isolation blowing film is installed on a bed body, then gas is inflated into the pressing air bag, the pressing air bag is expanded and swelled, the thermoplastic film is extruded through the isolation blowing film, the thermoplastic film is attached to the body of the patient, and preliminary positioning is conducted; after the pressing air bag is shrunk, the isolation air blowing film is inflated, and air is blown out to the surface of the thermoplastic film through the air blowing holes, so that the thermoplastic film is rapidly cooled and shaped, and radiotherapy positioning is completed; the device has the advantages of high positioning efficiency, convenience in use, high flexibility and comprehensive functions.

Systems and methods for determining multi-field doses for radiation therapy are provided. 1) one or more medical images of a patient and 2) a fluence map for each of a plurality of fields for radiation therapy of the patient are received. Fluence-related information is determined for each of the plurality of fields based on the fluence map. Fluence-related information for the plurality of fields is aggregated. A multi-field dose of the patient is determined based on the one or more medical images and the aggregated fluence-related information using a machine learning-based dose prediction network. And outputting the multi-field dose.

Methods and systems related to planning and delivering radiation treatment by modalities that move a radiation source along a trajectory relative to a subject while delivering radiation to the subject are provided. An artificial intelligence (AI) agent trained using reinforcement learning (and / or some other suitable form of machine learning) is used to control radiation delivery parameters in an effort to achieve a desired delivery of radiation therapy. In some embodiments, the AI agent selects appropriate control steps (e.g., radiation delivery parameters for a particular time step) while taking into account patient motion, difference(s) in patient anatomical geometry, etc.

The application discloses a radioactive temporal lobe injury risk prediction model training method and device, equipment and a storage medium. By fusing CT image samples and dose image samples, and combining clinical information and dose volume information, information omission of artificial feature extraction can be effectively avoided, the prediction accuracy of the model is improved, more reliable results are provided for radioactive temporal lobe injury risk prediction, and thus the current radiotherapy scheme is assisted to be adjusted by doctors, the treatment effect and prognosis effect of patients are improved, and the quality of life is improved.

There is provided with a method of treating cancer. A set of administration of a compound represented by General Formula (I) or a pharmaceutically acceptable salt thereof to a patient, at a dose such that 8 mg / kg or less of the compound represented by General Formula (I) is administered, and irradiation to the patient immediately following the administration is repeated. A total dosage of the irradiation to a cancer is 10 Gy or more.

1. The name of the design product: slide CT guide accelerator treatment system. 2. The use of the design product: for tumor radiotherapy, belongs to the field of radiotherapy equipment. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view 1. 5. The bottom of the design product is not easy to see or not visible during use, omit the top view.

A radiotherapy apparatus, a computer-implemented method, and a computer-readable medium are disclosed. The radiotherapy apparatus includes a radiation source, one or more imaging systems, and a controller communicatively coupled to the radiation source and the one or more imaging systems. The radiation source is configured to apply radiation to a treatment area overlapping with a subject according to a treatment plan. The one or more imaging systems are configured to generate image data for the subject. The controller is configured to: determine the relative distance between a target area of ​​the subject and an organ at risk of the subject based on the image data, wherein the treatment plan includes a prescribed dose for the target area; determine a buffer zone around the target based at least partially on the relative distance; and generate control signals for adjusting the radiotherapy in response to determining, based on the image data, that the treatment area is at least partially outside the buffer zone.

To alleviate stress for patients undergoing radiation therapy. [Solution] The treatment planning device according to the embodiment includes an acquisition unit that acquires location information indicating the location of pain in the patient's body and the patient's biological information, and an output unit that outputs based on at least one of the location information and the biological information when capturing medical images used to formulate a treatment plan for performing radiation therapy on the patient.

Embodiments of the present disclosure relate to systems and methods for generating treatment plan alternatives for radiation therapy. A system for generating a radiation therapy treatment plan alternative for radiation therapy is provided herein. In some embodiments, a system may include one or more processors to determine a first processing plan that satisfies an initial utility value; receiving data associated with a request to determine a second processing plan from the plurality of processing plans, the request specifying a desired first metric value different from the first metric value of the first processing plan; and determining a second processing plan from the plurality of processing plans, where a first metric value of the second processing plan satisfies a first metric threshold compared to first metric values of other processing plans of the plurality of processing plans. The one or more processors may provide data associated with the second processing plan to cause the device to operate in accordance with the second processing plan.

The application provides a CT imaging device and a radiotherapy equipment. In the CT imaging device, the opening size of a collimator is adjusted so that the emitted X-ray beam can be switched between a cone beam and a fan beam, and when the cone beam is generated, data acquisition is performed by using a first detector, and when the fan beam is generated, data acquisition is performed by using a second detector. In this way, the switching between the cone beam imaging mode and the fan beam imaging mode is realized under the condition of sharing the same imaging radiation source, so that the same CT imaging device simultaneously integrates the cone beam imaging function and the fan beam imaging function, which not only can save the occupied space of the equipment, but also greatly reduces the system cost, and improves the use flexibility under different CT imaging modes.

CD70 binding proteins or ligands, particularly CD27 polypeptides, and particularly variant CD27 extracellular binding domain polypeptides, are provided wherein the CD27 amino acid sequence is altered. The CD27 polypeptides and / or domains thereof, particularly the extracellular binding domains thereof are useful in the diagnosis and treatment of various conditions, including in cancer and immunotherapuetics. The CD27 polypeptides and / or domains thereof, particularly the extracellular binding domains thereof may also be used in lymphoid cell-mediated, including T cell-mediated, therapy, in chimeric antigen receptor (CAR) therapy, and / or in therapy in combination with chemotherapeutics, radiation therapy, immune modulators, cancer vaccines, cancer antigens, or anti-cancer agents. Particular variant CD27 polypeptides, extracellular domains, and novel CAR constructs are provided.

An intelligent system for optimizing radiotherapy for personalized radiotherapy, consisting of: • a genome data acquisition module configured to acquire and process a patient's genomic, molecular, and biomarker information; • a multimodal medical imaging module configured to acquire medical image data from one or more imaging modalities; • an image processing and automatic segmentation module configured to preprocess the acquired medical images, register multimodal images, segment tumors and organs at risk, and extract quantitative image features; • an artificial intelligence and data integration module configured to integrate genome data, imaging data, radiomic features, and clinical information to generate a patient-specific predictive model;• A treatment planning and dose optimization module configured to automatically generate and optimize a personalized treatment plan based on the integrated patient-specific model; • A digital twin and adaptive therapy module configured to simulate the patient-specific treatment response and continuously adjust the treatment plan during therapy; • A treatment monitoring and outcome prediction module configured to predict treatment response, disease progression, and radiation-induced toxicity based on longitudinal patient data; • A clinical decision support module configured to generate personalized treatment recommendations and support clinical decision-making;• A communication and data management module configured for the secure exchange, synchronization, and storage of clinical, imaging, genomic, and treatment-related information; and • An autonomous learning and systems management module configured to continuously improve predictive models and treatment optimization algorithms based on collected treatment outcomes, with the modules working together to generate, optimize, monitor, and continuously adapt personalized radiotherapy based on integrated genomic and multimodal medical imaging information.

Recombinant expression systems and radiation useful for the treatment of cancer The invention relates to a recombinant expression system comprising a nucleic acid construct, particularly for use in a combined gene and radiation therapy for the treatment of diseases, especially cancer. Said expression system is administered to a tumor that received prior low dose radiation. Additionally, the method comprises that at least one further tumor different from the one treated with expression system is subjected to radiation.

The present disclosure provides methods of predicting resistance to chemotherapy and / or radiation therapy in a subject in need thereof including detecting presence of lactic acid bacteria in a sample from the subject. In some aspects, the presence of lactic acid bacteria is indicative of resistance to chemotherapy and / or radiation therapy, thereby predicting resistance to chemotherapy and / or radiation therapy in the subject.

The utility model discloses a radiotherapy nursing frame relates to medical care technical field. Including stand, the stand bottom surface four corners are fixed with support leg, the lower part of support leg is provided with the lifting assembly of drive stand and carries out the lift, the stand bottom surface is fixed with U type connecting plate, is provided with the adjustment placing assembly on the stand, and the adjustment placing assembly includes the inverted L type slide plate of the head and tail two ends symmetry sliding of stand, is installed on the inverted L type slide plate of head position and is provided with the headrest pad, is installed on the inverted L type slide plate of tail position and is provided with the foot pad, and the middle part of U type connecting plate bottom surface rotates and inserts the vertical stick, and the vertical stick is fixed with the rotation gear on the sleeve setting. The utility model discloses the setting of adjustment placing assembly, according to the height of patient and thus adjusts the interval between headrest pad and foot pad, guarantees better adaptation to the head and foot of patient, and the support pad piece supports the back, waist and leg part position of patient, improves the use comfort of this nursing frame to some extent.

A substance which regulates immune-checkpoints for use as a medicament for treatment of a tumor of a patient wherein the administration pattern of the medicament comprises administering a therapeutically effective amount of the substance to the tumor, in one or more sessions, and implanting seeds (204) carrying radium-224 in the tumor for intra-tumoral alpha-emitter radiotherapy less than two weeks from administering the substance.