204 results about "Radiation therapy" patented technology

Disclosed herein are methods and systems to evaluate cost values for different radiotherapy treatment plans using external AI models. A method comprises presenting a user interface providing an interaction interface between a plurality of medical professionals communicating regarding a radiation therapy treatment of a patient during a tumor board meeting or a radiotherapy treatment planning process; receiving, from the interaction interface, a first input comprising a first patient attribute of the patient and a second input corresponding to the radiation therapy treatment of the patient; executing a machine learning language processing model using the first input and the second input to predict a task associated with generating a treatment plan for the patient; receiving, from the interaction interface, a third input; and when the third input does not correspond to the predicted task, presenting an indication of the predicted task.

Described herein are methods for monitoring the radiation delivery during a radiotherapy delivery session and providing a graphical representation of radiation delivery to an operator (e.g., a clinician, a medical physicist, a radiation therapy technologist). The graphics are updated in real-time, as radiation data is collected by the radiotherapy system, and in some variations, can be updated every 15 minutes or less. A variety of graphical representations (“graphics”) can be used to indicate the status of radiation delivery relative to the planned radiation delivery. Methods optionally include calculating a range of acceptable metric values, generating graphics that represent the range of acceptable metrics values, and generating a graphic that depicts the real-time values of those metrics overlaid with the range of acceptable metrics values.

Provided herein are methods for promoting or inducing hematopoietic regeneration, or preventing or treating hematopoietic deficiencies, or treating or ameliorating aplastic anemia induced especially by a chemotherapy, or a radiation therapy, comprising administering an effective amount of an adrenoreceptor agonist, especially a selective β2 adrenoreceptor agonist or a selective β3 adrenoreceptor agonist or a nonspecific β adrenoreceptor agonist.

Apparatuses and methods for treating tumors. A method of treatment may include reducing the microvasculature of a region between a tumor and a lumen through or adjacent to the tumor (e.g., by administering radiation therapy targeting the tumor), isolating a segment of a lumen proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment.

The invention provides a radiotherapy control method and a related device. The radiotherapy control method comprises the following steps: acquiring a heart motion model corresponding to an object to be subjected to radiotherapy; determining a to-be-sketched image from the plurality of medical images, and determining a moment corresponding to the to-be-sketched image as a target treatment moment, so that an operator performs target region sketching on the to-be-sketched image to obtain a corresponding sketched image; based on a heart motion model, determining a target electrocardiogram wave band and a target optical marker ball position corresponding to the sketching image; and performing radiotherapy on the to-be-radiotherapy object based on the target treatment moment, and if the deviation between the electrocardiogram wave band acquired by the electrocardiograph in real time and the target electrocardiogram wave band is smaller than a first preset threshold value and the deviation between the optical marking ball position acquired by the optical positioning system in real time and the target optical marking ball position is smaller than a second preset threshold value, performing radiotherapy on the to-be-radiotherapy object according to the sketched image. Through the method, the accuracy of radiotherapy is ensured.

The present disclosure provides anti-ULBP2 antibodies or antigen binding fragments thereof, including bispecific. The antibodies are administered in combination with a chemotherapy agent, a radiation therapy, and / or an immune checkpoint inhibitor for treatment of basal squamous cancer. The present disclosure also relates to methods and kits for detecting a predisposition to, determining the risk of, and guiding therapy for ULBP2 related disorders.

Example methods and systems for template generation and target structure tracking are described. In one example, a computer system may obtain (a) planning image data that is associated with a target structure of a patient requiring radiation therapy, or (b) transformed image data that is generated based on the planning image data. Based on the planning image data and / or the transformed image data, the computer system may generate first material property data that represents a particular material property associated with the target structure. Based on the first material property data, the computer system may generate a template that represents the particular material property. The template may be generated to be matchable against second material property data that also represents the particular material property for tracking the target structure during a treatment phase.

A method for cancer diagnosis and treatment. In particular, in identifying associations between biomedical markers which is indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular nasopharyngeal cancer (NPC) metastasis after radiation therapy. The biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably radiation therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, or all markers selected from CXCR6, ASPHD2, DDX39B and AGAP9. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular nasopharyngeal cancer, is provided, as well as a corresponding method for classifying a subject and a medical decision support system.

A microcapsule containing vitamin C and nitrate, said capsule comprising a wall material and a core material encapsulated in the wall material. The wall material comprises pectin and sodium carboxymethyl cellulose, and the core material comprises vitamin C, nitrate, and chitosan. The raw materials of the microcapsule comprise, in parts by weight: pectin 0.7-1.2 parts by weight, sodium carboxymethyl cellulose 0.7-1.2 parts by weight, chitosan 1 part by weight, and vitamin C and nitrate in a total amount of 0.3-1.2 parts by weight, the molar ratio of vitamin C to nitrate ions being 1:1-1:5. A use of the microcapsule in the preparation of a drug for preventing and / or treating damage to the salivary glands caused by radiation therapy, in particular a use in the preparation of a drug for preventing and / or treating damage to the salivary glands caused by radiation therapy for nasopharyngeal carcinoma.

A method and an apparatus for determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, such as in the tissue of a patient undergoing radiation therapy.

The invention relates to the technical field of tumor radiotherapy, in particular to an auxiliary imaging device for tumor radiotherapy. The invention provides an auxiliary imaging device for tumor radiotherapy, which comprises a mounting plate, a supporting seat, tumor emission therapy equipment, a therapy bed, a positioning mechanism and a control mechanism, the tumor emission therapy equipment is mounted on the right side of the mounting plate, the supporting seat is connected to the left side of the mounting plate, and the therapy bed is mounted on the upper part of the supporting seat; the upper side of the treatment bed is provided with a positioning mechanism and a control mechanism. Through cooperative use of the small air pump and the air bag, the head and body contours of a patient can be tightly attached, the stability and the static performance of the patient in the whole treatment process are ensured, imaging artifacts caused by slight movement are reduced through high-precision fixation, and the image quality and the resolution ratio are improved.

A protection device for tumor radiotherapy, characterized in that it comprises two symmetrically arranged mounting rails (1), a slider (9), a protection main plate (11) and a protection sub-plate (13); each of the mounting rails (1) is provided with a folding seat (4) along its extending direction; the folding seat (4) is provided with a foldable connecting rod (5); the other end of the connecting rod (5) is provided with a C-shaped clamping head (6); a threaded rod (7) with a threaded connection is arranged on the C-shaped clamping head (6); the threaded rod (7) passes through one side of the open end of the C-shaped clamping head (6); the other end of the threaded rod (7) is provided with a clamping block (8); each mounting rail (1) is provided with a slide track No.1 (3); Electric telescopic rods (10) are provided at the four corners of the underside of the protective main plate (11), and a slider (9) is provided at the lower end of each of the electric telescopic rods (10); an opening portion (12) is provided which extends longitudinally through the main body of the protective main plate (11); the protective main plate (11) is each provided with a No. 2 slideway (15) on the left and right sides of the opening portion (12); a plurality of evenly distributed protective sub-plates (13) are provided in the No. 2 slideway (15); each of the protective sub-plates (13) can respectively perform a linear reciprocating movement along the extending direction of the No. 2 slideway (15).

In various embodiments, a method of radiation therapy may include loading a planning image of a target within a human body. Furthermore, a position of the target may be monitored. An occurrence of substantial alignment between the position of the target and the position of the target in the planning image may be calculated. Furthermore, after the calculation, a radiation beam may be triggered to deliver a dose to the target within a brief period of time (e.g., less than one second).

The invention relates to the field of orthopedic appliances for bone or joint non-surgical treatment and the field of electrotherapy, magnetic therapy and radiation therapy, in particular to a postpartum infrared rehabilitation treatment device which comprises a treatment bed, a pelvis containing groove is formed in the treatment bed, an infrared heater is arranged at the bottom of the pelvis containing groove, and a transparent bottom plate is arranged at the bottom of the pelvis containing groove. A mounting base is arranged at the tail of the treatment bed, two fixing plates are slidably arranged on the mounting base, a synchronous driving mechanism is arranged in the mounting base and used for driving the two fixing plates to be synchronously separated or synchronously drawn close, connecting plates are slidably arranged on the fixing plates, bandages are arranged on the connecting plates, one ends of the bandages are fixedly connected with the connecting plates, and the other ends of the bandages are fixedly connected with the connecting plates. And the other end of the bandage is detachably connected with the connecting plate. The problem that in the prior art, the whole repairing process is driven by two legs of a patient, and labor is consumed is solved.

The present invention relates to MSLN-specific binding constructs comprising a designed ankyrin repeat domain with binding specificity for MSLN and a chelator capable of bonding to a radionuclide, as well as to such MSLN-specific binding constructs comprising a half-life extending moiety with binding specificity for serum albumin. The invention further relates to methods of producing such radio-labelled MSLN-specific binding constructs, pharmaceutical compositions comprising such constructs, and the use of such constructs or pharmaceutical compositions in methods for treating, imaging or diagnosing diseases, such as cancer.

A linear accelerator for a radiation therapy system includes a plurality of cavities aligned along a length of the linac and a channel extending between adjacent cavities of the plurality of cavities. The plurality of cavities include a first material and the channel includes a second material different from the first material.

A prostate-specific membrane antigen (PSMA)-targeting conjugate having a phosphonate backbone, which is used for tumor detection after chelation of a diagnostic nuclide and is used for radiation therapy after being combined with a treatment-type nuclide. A conjugate nuclide chelation part is replaced with a fluorescent probe or a cytotoxic drug so that the PSMA-targeting conjugate can then be used for diagnosis and treatment of diseases.

The invention provides a dose adjustment mechanism, and the subject of the invention is to reduce the influence of radiation in the dose adjustment mechanism of a radiation therapy device and suppress the occurrence of faults. The dose adjustment mechanism is characterized in that the dose adjustment mechanism (40) is provided with: an actuator (42) that is disposed apart from the radiation axis of the radiation therapy device (10) that irradiates radiation; and a grader (33) as an interference element that is moved in the vertical direction with respect to the radiation axis by the operation of an actuator (42) and that can switch between a state in which the grader is disposed on the radiation axis and a state in which the grader is not disposed on the radiation axis, the operation axis of the actuator (42) not intersecting the radiation axis.

A method of treating or preventing adverse outcomes associated with tissue plasminogen activator (tPA) administration, cerebral edema-related side effects, cerebral edema associated with radiation therapy, or migraine headaches by administering an effective amount of a SUR1-TRPM4 channel inhibitor, such as glyburide, and optionally the co-administration of a second therapeutically active agent, to a subject in need thereof. Adverse outcomes associated with tPA include cerebral hemorrhage, cerebral edema, physical impairment or death. The administration of the SUR1-TRPM4 channel inhibitors occurs prior to the radiation therapy, during the radiation therapy, after the radiation therapy, or combinations thereof. The SUR1-TRPM4 channel inhibitor is administered prior to surgical excision of a brain tumor, CAR-T therapy, or administration of flutarabine. Alternatively, or in addition, the SUR1-TRPM4 channel inhibitor is administered prior the onset of the cerebral edema-related side effects.

The invention provides a therapy apparatus and a radiation therapy apparatus capable of reducing the limitation on the movement range of a therapy table while suppressing the area of a therapy room. The movable door (70) slides to the left side in the transverse direction (D1) relative to the irradiation opening (55a) during the first sliding, and slides to the right side in the transverse direction (D1) relative to the irradiation opening (55a) during the second sliding. Namely, when the movable door (70) slides towards one side in the transverse direction (D1), the movable door (70) does not exist on the other side, and when the movable door (70) slides towards the other side in the transverse direction (D1), the movable door (70) does not exist on the one side. Therefore, when the treatment table (60) moves close to the wall part (103) (as shown in the states (a) and (b) in Figure 5), the movable door (70) slides to the side opposite to the treatment table (60), so that the space of the treatment table (60) can be ensured. At this time, even if the movable door (70) and the irradiation port (55a) are not excessively spaced apart, interference between the movable door (70) and the treatment table (60) can be suppressed.

The ability to improve the adjusting of technical parameters in therapy plans found by Pareto navigation constitutes a technical problem, along with facilitating the decision-making of the planner (also called user) and simplifying the mathematical calculation of the solution. Proposed is a way to find and establish a therapy plan among a plurality of plan proposals for cancer therapy, each plan proposal representing as a solution one point in a navigation space (N) containing a plurality of setting parameters and establishing in a machine space (M) a setting for radiation doses to be administered by a radiation therapy machine for cancer therapy. The navigation space (N) contains at least one Pareto front (200) behind or on which available treatment plans are located as possible solutions and among which a user navigates, whereby a first plurality of available solutions calculated in advance as plan proposals is provided in a memory and retrieved or read out from the memory for display. The retrieved or read-out plan proposals are shown on a display and used by the user for navigation, whereby a large number of Pareto-optimal solutions with physical values or evaluations of dose values can be found among the points. Moreover, such solutions are also shown that are almost Pareto-optimal, within a tolerance range of at most ±5% from the Pareto optimum. In this way, a large first set of points with the physical values or evaluations of dose values is created and then stored in the memory. From this, a second set of points is calculated, which defines clinical targets. A decision space (D) is provided and shown in which at least the clinical targets are plotted on target axes (76, 876, 776). This is without the possibility of navigating in the decision space (D) on the target axes of the clinical targets, whereas binary selections in the decision space are made in the manner of restrictors to specify which plan proposals are not used as therapy plans. This enables a desired therapy plan to be found and determined from the large number of plan proposals.

Described herein are radiotherapeutic agents that target tumor cells that express the follicle-stimulating hormone receptor (FSHR), and their use in the treatment and / or diagnosis of cancer.

The present invention relates to a radiation therapy or microwave therapy or cryosurgery or ultrasound therapy reference positioning marker (5) adapted to be implanted in tissue using a hollow injection needle (4), wherein the marker comprises an elongated object with a longitudinal axis (CL) and have cross-sections (A-A, B-B, C-C, D-D, E-E, F-F) of the object, perpendicular to said longitudinal axis (CL), being adapted to fit within an inner diameter (DI) of the needle (4), wherein the marker (5) comprises a plurality of first segments (1) having a first cross-section and one or more second segments (2) having a second set of cross-sections, wherein an area of the first cross-section is selected relatively larger than area / s of the second set of cross-sections, and wherein the first segments (1) and second segments (2) are arranged alternately after each other along the longitudinal axis (CL), wherein the one or more of second segments (2) are provided with one or more deformation segments (22) adapted to ensure that any deformation of the plurality of second segments, when positioned inside the needle, occurs in a predetermined location / s between adjoining first segments, such that the plurality of first segments remain linearly aligned in the injection needle when it encounters resistance during implantation into the tissue.

The utility model provides a limb tumor radiotherapy body surface mark, which comprises a mark body, the mark body is provided with more than three mutually connected edges, the outer contour of the mark body is a regular polygon, the top surface of the mark body is arc-shaped along the height direction of the mark body, the mark body is provided with an accommodating cavity, and the accommodating cavity is provided with a cavity. A contrast agent is arranged in the accommodating cavity; the bonding piece is arranged at the bottom of the mark body, and the bonding piece is used for being bonded to the body surface of a patient. In addition to the human skeleton, the CT developing mark is added on the skin, so that the image matching accuracy is improved, the radiotherapy accuracy is improved, the curative effect is improved, and the side effect is reduced. Meanwhile, the limb change conditions, such as limb swelling and the like caused by tumor enlargement, of the patient at two time nodes during CT positioning and before treatment can be found in time through the position change of the body surface mark.

The invention discloses a comprehensive tumor radiotherapy bed, and relates to the technical field of radiotherapy. The device comprises a bottom frame, a plurality of lifting parts are installed at the top end of the bottom frame, a top frame is fixedly connected between the top ends of the lifting parts, and height adjusting mechanisms are installed between the two sides of the bottom frame and the two sides of the top frame and used for being matched with the lifting parts to vertically move the top frame; a bending piece is placed at the top end of the top frame, a back supporting mechanism is installed between the bending piece and the bottom frame, a leg supporting piece is rotationally connected to one side of the bending piece, a leg supporting mechanism is installed between the leg supporting piece and the bottom frame, and the leg supporting mechanism is used for being matched with the back supporting mechanism to adjust the posture of radiotherapy of a patient. According to the invention, by controlling the pitching adjustment of the upper body and the lower body of the patient in a segmented manner, the radiotherapy of partial pitching body position is realized, and the radiotherapy precision of the treatment point position during the pitching body position treatment is improved; and the comfort of the patient in the lifting radiotherapy state is improved through more stable height adjustment.

The present disclosure relates to methods of treating a tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of a T-cell checkpoint inhibitor in combination with chemotherapy and / or radiation therapy, wherein the subject has reduced levels of CD73 protein or CD73 activity compared to a normal subject. In some embodiments, the method further comprises administering a CD73 inhibitor prior to or concurrently with the combined T-cell checkpoint inhibitor and chemotherapy and / or radiation therapy.

The present invention relates to an expression system comprising a first and / or second nucleic acid construct for combined gene and radiation therapy for the treatment of diseases, particularly cancer. The first nucleic acid construct encodes a target STING that responds to a STING agonist that recognizes the target STING but not human STING and its naturally occurring variants, wherein the sequence encoding the target STING is operably linked to elements that allow the expression and / or translation of the target STING. The second nucleic acid construct comprises a therapeutic gene sequence operably linked to a STING-responsive promoter or a radiation-inducible promoter. The expression system is administered before, simultaneously with, or after irradiation with low dose radiation, followed or not by another cycle of radiation therapy and / or treatment with a STING agonist.

The present invention discloses a flexible vital sign monitoring system. The system comprises: a flexible substrate, a flexible circuit arranged on the flexible substrate, a sensor module and a wireless communication module; the sensor module is used to collect sensor information; the sensor module comprises at least two of a flexible humidity sensor, a flexible pressure sensor, a flexible temperature sensor and a flexible air flow sensor; the sensor information comprises: at least two of the humidity information on the surface of human skin collected by the flexible humidity sensor, the pressure information on the surface of human skin collected by the flexible pressure sensor, the temperature information on the surface of human skin collected by the flexible temperature sensor and the airflow information under the nose of the human body collected by the flexible air flow sensor. The wireless communication module is used to transmit the sensor information to a remote monitoring terminal. Any flexible sensor in the sensor module is electrically connected to the wireless communication module through a flexible circuit. The flexible vital sign monitoring system provided by the present invention is comfortable to wear, has a good user experience, and is simple and easy to operate.