141 results about "Radiation therapy" patented technology

Example methods and systems for template generation and target structure tracking are described. In one example, a computer system may obtain (a) planning image data that is associated with a target structure of a patient requiring radiation therapy, or (b) transformed image data that is generated based on the planning image data. Based on the planning image data and / or the transformed image data, the computer system may generate first material property data that represents a particular material property associated with the target structure. Based on the first material property data, the computer system may generate a template that represents the particular material property. The template may be generated to be matchable against second material property data that also represents the particular material property for tracking the target structure during a treatment phase.

In various embodiments, a method of radiation therapy may include loading a planning image of a target within a human body. Furthermore, a position of the target may be monitored. An occurrence of substantial alignment between the position of the target and the position of the target in the planning image may be calculated. Furthermore, after the calculation, a radiation beam may be triggered to deliver a dose to the target within a brief period of time (e.g., less than one second).

The present invention relates to MSLN-specific binding constructs comprising a designed ankyrin repeat domain with binding specificity for MSLN and a chelator capable of bonding to a radionuclide, as well as to such MSLN-specific binding constructs comprising a half-life extending moiety with binding specificity for serum albumin. The invention further relates to methods of producing such radio-labelled MSLN-specific binding constructs, pharmaceutical compositions comprising such constructs, and the use of such constructs or pharmaceutical compositions in methods for treating, imaging or diagnosing diseases, such as cancer.

A linear accelerator for a radiation therapy system includes a plurality of cavities aligned along a length of the linac and a channel extending between adjacent cavities of the plurality of cavities. The plurality of cavities include a first material and the channel includes a second material different from the first material.

A prostate-specific membrane antigen (PSMA)-targeting conjugate having a phosphonate backbone, which is used for tumor detection after chelation of a diagnostic nuclide and is used for radiation therapy after being combined with a treatment-type nuclide. A conjugate nuclide chelation part is replaced with a fluorescent probe or a cytotoxic drug so that the PSMA-targeting conjugate can then be used for diagnosis and treatment of diseases.

The invention provides a therapy apparatus and a radiation therapy apparatus capable of reducing the limitation on the movement range of a therapy table while suppressing the area of a therapy room. The movable door (70) slides to the left side in the transverse direction (D1) relative to the irradiation opening (55a) during the first sliding, and slides to the right side in the transverse direction (D1) relative to the irradiation opening (55a) during the second sliding. Namely, when the movable door (70) slides towards one side in the transverse direction (D1), the movable door (70) does not exist on the other side, and when the movable door (70) slides towards the other side in the transverse direction (D1), the movable door (70) does not exist on the one side. Therefore, when the treatment table (60) moves close to the wall part (103) (as shown in the states (a) and (b) in Figure 5), the movable door (70) slides to the side opposite to the treatment table (60), so that the space of the treatment table (60) can be ensured. At this time, even if the movable door (70) and the irradiation port (55a) are not excessively spaced apart, interference between the movable door (70) and the treatment table (60) can be suppressed.

The ability to improve the adjusting of technical parameters in therapy plans found by Pareto navigation constitutes a technical problem, along with facilitating the decision-making of the planner (also called user) and simplifying the mathematical calculation of the solution. Proposed is a way to find and establish a therapy plan among a plurality of plan proposals for cancer therapy, each plan proposal representing as a solution one point in a navigation space (N) containing a plurality of setting parameters and establishing in a machine space (M) a setting for radiation doses to be administered by a radiation therapy machine for cancer therapy. The navigation space (N) contains at least one Pareto front (200) behind or on which available treatment plans are located as possible solutions and among which a user navigates, whereby a first plurality of available solutions calculated in advance as plan proposals is provided in a memory and retrieved or read out from the memory for display. The retrieved or read-out plan proposals are shown on a display and used by the user for navigation, whereby a large number of Pareto-optimal solutions with physical values or evaluations of dose values can be found among the points. Moreover, such solutions are also shown that are almost Pareto-optimal, within a tolerance range of at most ±5% from the Pareto optimum. In this way, a large first set of points with the physical values or evaluations of dose values is created and then stored in the memory. From this, a second set of points is calculated, which defines clinical targets. A decision space (D) is provided and shown in which at least the clinical targets are plotted on target axes (76, 876, 776). This is without the possibility of navigating in the decision space (D) on the target axes of the clinical targets, whereas binary selections in the decision space are made in the manner of restrictors to specify which plan proposals are not used as therapy plans. This enables a desired therapy plan to be found and determined from the large number of plan proposals.

Described herein are radiotherapeutic agents that target tumor cells that express the follicle-stimulating hormone receptor (FSHR), and their use in the treatment and / or diagnosis of cancer.

The present invention relates to a radiation therapy or microwave therapy or cryosurgery or ultrasound therapy reference positioning marker (5) adapted to be implanted in tissue using a hollow injection needle (4), wherein the marker comprises an elongated object with a longitudinal axis (CL) and have cross-sections (A-A, B-B, C-C, D-D, E-E, F-F) of the object, perpendicular to said longitudinal axis (CL), being adapted to fit within an inner diameter (DI) of the needle (4), wherein the marker (5) comprises a plurality of first segments (1) having a first cross-section and one or more second segments (2) having a second set of cross-sections, wherein an area of the first cross-section is selected relatively larger than area / s of the second set of cross-sections, and wherein the first segments (1) and second segments (2) are arranged alternately after each other along the longitudinal axis (CL), wherein the one or more of second segments (2) are provided with one or more deformation segments (22) adapted to ensure that any deformation of the plurality of second segments, when positioned inside the needle, occurs in a predetermined location / s between adjoining first segments, such that the plurality of first segments remain linearly aligned in the injection needle when it encounters resistance during implantation into the tissue.

The present disclosure relates to methods of treating a tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of a T-cell checkpoint inhibitor in combination with chemotherapy and / or radiation therapy, wherein the subject has reduced levels of CD73 protein or CD73 activity compared to a normal subject. In some embodiments, the method further comprises administering a CD73 inhibitor prior to or concurrently with the combined T-cell checkpoint inhibitor and chemotherapy and / or radiation therapy.

The invention discloses a TCP and multi-NTCP combination optimal dose calculation method and system based on deep learning, relates to the technical field of radiotherapy, and aims to solve the problems of insufficient multi-source data integration, unbalanced multi-organ protection and low individualized precision in traditional dose optimization. The method comprises the following steps: acquiring a CT image of a target patient, a tumor and normal tissue dose-volume histogram (DVH), baseline clinical data and follow-up data after radiotherapy of a patient group; constructing a multi-modal feature data set and an annotation data set through spatial alignment and normalization processing, training a deep learning joint prediction model, synchronously outputting TCP values corresponding to candidate doses and NTCP values of at least three organs at risk, and constructing a fitting curve; and through a single-organ net income formula, a multi-organ comprehensive net income formula and an optimal dose screening formula, quantifying income-risk balance and screening an optimal dose for maximizing the comprehensive net income. According to the invention, through cooperation of deep learning and an exclusive formula system, dynamic quantitative balance of multi-organ unbiased protection and tumor control is realized, individualized precision and clinical landing of radiotherapy dose planning are improved, and the method is suitable for precise radiotherapy scenes of various solid tumors.

Some embodiments relate to imageable radioisotope microspheres. In some embodiments, the imageable microspheres are radiolabeled with an imageable radioisotope. In some embodiments, the imageable radioisotope is directly chemically coupled to the surface of the microsphere matrix. In some embodiments, the imageable microspheres can be used as surrogate particles to predict the distribution of therapeutic microspheres containing radiotherapeutic isotopes.

Provided is a peripheral blood biomarker for evaluating the antitumor immune effect of radiation therapy. Also provided is a method in which the composition of cell subpopulation in a sample obtained from a subject is used as an index for immune activation in the subject caused by a radiation therapy. By comparing, with a reference, the amount of CD4+ T cell subpopulation that correlates with dendritic cell stimulation in an antitumor immune response or the amount of dendritic cell subpopulation that correlates with the dendritic cell stimulation in an antitumor immune response, the presence or absence of, and / or the magnitude of, immune activation occurring in the subject as a result of a radiation therapy can be determined.

The present disclosure relates to representation learning for treatment response prediction of risk organs and total tumor volume. For predicting the response of radiation therapy, radiomics is used for unsupervised machine training of an encoder-decoder network to predict based on input of image data, such as computed tomography image data, and from segmentation. Then, the trained encoder is used to generate latent representations to be used as input to different classifiers or regressors for predicting the treatment response, such as one classifier for predicting the response for a risk organ and another classifier for predicting another type of response for a risk organ or predicting the response for a tumor.

The invention relates to a direct drive system for rack rotation. A radiation therapy system comprising: a base secured to or resting on a support surface located outside the radiation therapy system; a rotatable gantry on which a radiation source for delivering therapy is mounted, where the rotatable gantry is rotatably coupled to the base via a bearing; and an electric motor for rotating the rotatable gantry and the portion of the bearing fixed to the gantry. The electric motor includes: a first assembly fixed to a base; and a second assembly fixed to the gantry and separated from the first assembly by an air gap, where magnetic flux through the air gap causes the electric motor to rotate the rotatable gantry and the portion of the bearing fixed to the rotatable gantry.

This application discloses a compound or a pharmaceutically acceptable salt thereof, said compound comprising a compound of formula (I) or a compound of formula (II). A radioactive element preparation comprising thereof and a radioactive element chelated therewith is also disclosed. Its use in the preparation of reagents targeting CXCR4, particularly CXCR4 tracers, more particularly in vivo CXCR4 tracers, or reagents that specifically bind to cells expressing CXCR4 is also disclosed. [Targeting Peptide-I]-Xaa1-X 1 (R 1 )L 1 -[Connector]-R x n1 (I), R x n1 -[Connector]-X 1 (R 1 )L 1 -Xaa1-[targeting peptide-II](II).

The present disclosure provides a radiotherapy plan generation method, comprising: acquiring multi-modal data of a patient, the multi-modal data comprising medical image data and non-image data, the non-image data being text information with medical semantics; inputting the medical image data and the non-image data into a target agent, and determining a cognitive confidence of the target agent for a condition suffered by the patient; determining an execution action according to the cognitive confidence and the non-image data; in response to the execution action being a first execution action, performing segmentation on a tumor target region and / or an organ at risk of the patient based on the medical image data to obtain a segmentation result; and in response to the execution action being a second execution action, generating a radiotherapy plan based on the segmentation result.

Methods of reducing skin fibrosis by prophylactically treating skin prior to radiation therapy are described herein. The methods include applying an effective amount of DFO to skin that may be subjected to radiation, e.g., during treatment for cancer at a treatment site. The DFO may be administered transdermally.

A proton cyclotron is provided for dedicated use in head, neck and eye cancers, tumors or other medical conditions including pediatric and other cancers or medical conditions. The method of using a proton cyclotron for treating a tumor, cancer or medical condition of a patient includes positioning the patient on a support platform, such as on a patient table or in a robotic chair, and irradiating the tumor, cancer or other medical condition using a proton particle beam from the cyclotron for a predetermined time sufficient to treat the tumor, cancer or medical condition, wherein the proton particle beam produced by the cyclotron has an energy in a range of 70 MeV to 150 MeV and has a beam current in an amount suitable for radiation therapy, as can include a variable range of beam current for the radiation therapy.

The invention discloses a radiotherapy positioning device and method for tumor radiotherapy, relates to the technical field of radiotherapy positioning, and is used for solving the problem of low treatment efficiency caused by inconvenient operation and low positioning efficiency in the prior art. The bed body is also provided with a thermoplastic film fixing assembly used for fixing the thermoplastic film to a radiotherapy part. A thermoplastic film is attached to the upper portion of a radiation part of the body of a patient, a fixing plate with a pressing air bag and an isolation blowing film is installed on a bed body, then gas is inflated into the pressing air bag, the pressing air bag is expanded and swelled, the thermoplastic film is extruded through the isolation blowing film, the thermoplastic film is attached to the body of the patient, and preliminary positioning is conducted; after the pressing air bag is shrunk, the isolation air blowing film is inflated, and air is blown out to the surface of the thermoplastic film through the air blowing holes, so that the thermoplastic film is rapidly cooled and shaped, and radiotherapy positioning is completed; the device has the advantages of high positioning efficiency, convenience in use, high flexibility and comprehensive functions.

The treatment for pediatric solid tumor patients traditionally consists of a combination of chemotherapy, surgery, and radiation therapy. Targeted therapies, designed specifically for individual tumors, allow a more focused approach to treatment aimed at improving overall survival and diminishing side effects. This invention is directed to antibodies against CD99 and methods of use thereof.

This application relates to the technical field of radiotherapy devices, and particularly to a tumor radiotherapy control system, which includes a CPU module, an action module, a centering module, and a radiation source module. Among them: The action module is used to receive the first centering signal and the second centering signal output by the CPU module to drive the centering module to move to a position directly opposite the target center, and is also used to receive a reset signal to drive the centering module back to a preset initial position; The centering module includes a light centering unit and an image acquisition unit. The light centering unit is used to emit centering light to project a centering mark at the target area position, and the image acquisition unit is used to obtain the centering status image signal in the target area and output it to the CPU module; The radiation source module includes a motion unit and a radiation source. The radiation source module is used to receive the current position information to control the motion unit to drive the radiation source to move to the current position information. The centering module is used to achieve aiming at the radiotherapy target area, realizing the function of automatic alignment of the radiotherapy instrument.

The present invention relates to a computer-implemented method for optimizing tolerance values of operating parameters of a particle acceleration system allowing a plurality of particle pencil beams accelerated along an irradiation axis (Z) to deposit a dose into a structure of interest of a patient according to a treatment plan (= TP) by means of a pencil beam scanning (= PBS). The method calculates a dose (rate) volume histogram (cD(R)VH) of a statistically representative number N of values randomly selected within a predefined confidence level (CLj) of a preselected tentative statistical distribution of these operating parameters and compares the thus obtained cD(R)VH with an acceptable variation band (BV) of a target D(R)VH. Once the tentative statistical distribution (Tj) yields N calculated cD(R)VHs all falling within the acceptable variation band (BV), the tentative statistical distribution is set as a final statistical distribution (Tf) and the particle acceleration system can be programmed with the final statistical distribution (Tf).

Systems and methods for determining multi-field doses for radiation therapy are provided. 1) one or more medical images of a patient and 2) a fluence map for each of a plurality of fields for radiation therapy of the patient are received. Fluence-related information is determined for each of the plurality of fields based on the fluence map. Fluence-related information for the plurality of fields is aggregated. A multi-field dose of the patient is determined based on the one or more medical images and the aggregated fluence-related information using a machine learning-based dose prediction network. And outputting the multi-field dose.

Methods and systems related to planning and delivering radiation treatment by modalities that move a radiation source along a trajectory relative to a subject while delivering radiation to the subject are provided. An artificial intelligence (AI) agent trained using reinforcement learning (and / or some other suitable form of machine learning) is used to control radiation delivery parameters in an effort to achieve a desired delivery of radiation therapy. In some embodiments, the AI agent selects appropriate control steps (e.g., radiation delivery parameters for a particular time step) while taking into account patient motion, difference(s) in patient anatomical geometry, etc.

The application discloses a radioactive temporal lobe injury risk prediction model training method and device, equipment and a storage medium. By fusing CT image samples and dose image samples, and combining clinical information and dose volume information, information omission of artificial feature extraction can be effectively avoided, the prediction accuracy of the model is improved, more reliable results are provided for radioactive temporal lobe injury risk prediction, and thus the current radiotherapy scheme is assisted to be adjusted by doctors, the treatment effect and prognosis effect of patients are improved, and the quality of life is improved.

There is provided with a method of treating cancer. A set of administration of a compound represented by General Formula (I) or a pharmaceutically acceptable salt thereof to a patient, at a dose such that 8 mg / kg or less of the compound represented by General Formula (I) is administered, and irradiation to the patient immediately following the administration is repeated. A total dosage of the irradiation to a cancer is 10 Gy or more.