53 results about "Pet tracer" patented technology

The invention provides a precursor compound of a PET agent and a preparation method and application of the precursor compound, which belong to the field of radiopharmaceutical labeling. The PET agentand the compound are simple to prepare, short in preparation time and high in radiochemical yield, have the advantages of good in-vivo and in-vitro stability, high specificity, high intake and the like, and can be used for accurately and stably detecting and positioning tumor or inflammatory parts.

There is provided a radiolabelled peptide-based compound for diagnostic imaging using positron emission tomography (PET). The compound may thus be used for diagnosis of malignant diseases. The compound is particularly useful for imaging of somatostatin overexpression in tumors, wherein the compound is capable of being imaged by PET when administered with a target dose in the range of 150-350 MBq, such as 150-250 MBq, preferable in the range of 191-210 MBq.

The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.

A method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition rapidly in high yield using an organic boron compound whose toxicity is not so high as a substrate. A kit for preparing a PET tracer and a method of producing a PET tracer can be practiced using the rapid methylation method. In an aprotic polar solvent, methyl iodide or X—CH2F (wherein X is a functional group which can be easily released as an anion), and an organic boron compound in which an aromatic ring or an alkenyl group is attached to boron are subjected to cross-coupling in the presence of a palladium(0) complex, a phosphine ligand, and a base.

Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18F− are described. The active ester including [18F]F-Py-TFP and [18F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [18F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor.

The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for the trapping of [18F]fluoride and recovery of [18O]water.

The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [18F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.

Fatty acid analogue ( FAA) molecules comprising positron-emitting radionuclides, salts thereof, and FAA-triglycerides are disclosed Also disclosed are methods of synthesis, and methods of imaging distribution and metabolism of fatty acids and fatty acid triglycerides.

The invention relates to symmetric pyrimidyl iodonium salt and a preparation method thereof. The structural formula of the symmetric pyrimidyl iodonium salt is shown in the description. The preparation method comprises the steps that alcohol reacts with sodium hydride, then the reaction product drips into the reaction product of 5-bromouracil and phosphorus oxychloride, the reaction product reacts with a butyl lithium reagent after reaction and then reacts with simple substance iodine and organic metal halide respectively to obtain a 5-iodine-2,4-dialkoxyl pyrimidine and a metal pyrimidine derivative; the 5-iodine-2,4-dialkoxyl pyrimidine reacts with a nitrogen-fluorine reagent and TMSX-1 to obtain a 2,4-dialkyl pyrimidyl trivalent iodine intermediate and then reacts with TMSX-2 and the metal pyrimidine derivative, then anionic sodium or potassium salt is added to perform extraction, and the symmetric pyrimidyl iodonium salt is obtained. The oxidation method adopted by the preparation method of the symmetric pyrimidyl iodonium salt is acid-free, efficient and moderate. The symmetric pyrimidyl iodonium salt is used for efficient preparation of PET tracer agent <18>F-5-fluorouracil, and the poor problems of poor selectivity, low productivity, difficult separation and the like are avoided.