6 results about "Pet tracer" patented technology

The application discloses a PET tracer targeting carbonic anhydrase IX (CA IX) and a preparation method and application thereof. 68 The tracer is prepared from a DOTA-bis-sulfonamide precursor compound and GaCl3 reaction. The tracer has high hydrophilicity, excellent stability in vitro and in vivo, low uptake of non-target organs and is mainly excreted through the kidney. Micro-PET / CT imaging shows that the tumor uptake is linearly correlated with the CA IX protein expression level measured by immunohistochemistry. Acute toxicity experiments show that the tracer has good biological safety. The application further provides a radiopharmaceutical composition containing the tracer and application of the tracer in preparation of a PET imaging agent for diagnosing CA IX positive tumors. The tracer has the advantages of high labeling efficiency, low background interference, accurate quantification and potential integration of diagnosis and treatment, and is suitable for precise molecular imaging of CA IX high expression tumors such as clear cell renal cell carcinoma and colorectal cancer.

The present application provides a PET tracer targeting cannabinoid receptor type 2 and a preparation method and application thereof.

The present invention relates to a device that allows to fully automate radiochemical purity analysis of radiolabelled solution samples on the basis of a chromatogram obtained by Thin Layer Chromatography (TLC), said device comprising a disposable TLC strip holder assembly, a radioactivity detector and an automatic equipment containing a pipettor.

The present invention relates to new and inventive compounds of formula (I). The compounds are useful as PET (positron emission tomography) tracer.

The application belongs to the technical field of biological medicine, and particularly relates to design, synthesis and application of a tumor-targeting polypeptide tracer. The structure of the tumor-targeting polypeptide tracer comprises a tumor-targeting polypeptide (targeting vascular endothelial growth factor receptor 2 of tumor cells), a linker and a radionuclide chelating group. The polypeptide tracer provided by the application is modified by methionine at different sites to form a thioether bridge cyclic peptide, so that the tumor targeting ability, membrane penetration performance and in-vivo drug metabolism of the targeting polypeptide are improved, high concentration enrichment and long-time retention in the tumor tissue site can be realized, the targeting of the PET tracer is improved, and a more accurate and safer tumor tracer is realized.

This invention relates to the field of tracer preparation technology, and specifically discloses a method for preparing a positron emission tomography (PET) tracer that penetrates the blood-brain barrier and targets hypoxia-inducible factor (HIF). The tracer is a compound with HIF targeting and rapid brain tumor enrichment capabilities, and comprises the following parts: a) a short-half-life radionuclide portion for PET imaging; b) a HIF-1α protein-binding domain; and c) a lipophilic linker / regulatory domain for modulating intracranial pharmacokinetics. This method for preparing a PET tracer that penetrates the blood-brain barrier and targets HIF integrates high-affinity targeting and tumor microenvironment response mechanisms, giving it excellent targeting specificity, rapid brain penetration and enrichment capabilities, and ideal rapid systemic clearance characteristics, thereby obtaining high-contrast, low-background, high-quality images.