460 results about "Positron" patented technology

The invention is related to nuclear physics, medicine and oil industry, namely to the measurement of x-ray, gamma and alpha radiation; control for trans uranium nuclides in the habitat of a man; non destructive control for the structure of heavy bodies; three dimensional positron-electron computer tomography, etc.The essence of the invention is in additional ingredients in a chemical composition of a scintillating material based on crystals of oxyorthosilicates, including cerium Ce and crystallized in a structural type Lu2SiO5.The result of the invention is the increase of the light output of the luminescence, decrease of the time of luminescence of the ions Ce3+, increase of the reproducibility of grown crystals properties, decrease of the cost of the source melting stock for growing scintillator crystals, containing a large amount of Lu2O3, the raise of the effectiveness of the introduction of SCintillating crystal luminescent radiation into a glass waveguide fibre, prevention of cracking of crystals during the production of elements, creation of waveguide properties in scintillating elements, exclusion of expensive mechanical polishing of their lateral surface.

A camera sub-module is provided for providing tomographic imaging of radiation emissions generated internally by a body. The camera sub-module includes a radiation-emitting layer having a radioactive source for emitting transmission emissions, and at least one radiation-detection layer for contemporaneously detecting and permitting differentiation between the transmission emissions and emissions generated internal to an imaged body administered with a positron-emitting radiotracer. Also provided herein are imaging systems, scanners, and other apparatus and methods.

The invention provides a method and apparatus for preparation of radiochemicals, such as PET molecular imaging probes, wherein the reaction step or steps that couple the radioactive isotope to an organic or inorganic compound to form a positron-emitting molecular imaging probe are performed in a microfluidic environment. The method for synthesizing a radiochemical in a microfluidic environment comprises: i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port; ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor; iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor; v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, the reacting step resulting in formation of a radiochemical; and vi) collecting the radiochemical from the outlet port of the micro reactor.

Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.

Tomography by emission of positrons (pet) system dedicated to examinations of human body parts such as the breast, axilla, head, neck, liver, heart, lungs, prostate region and other body extremities which is composed of at least two detecting plates (detector heads) with dimensions that are optimized for the breast, axilla region, brain and prostrate region or other extremities; motorized mechanical means to allow the movement of the plates under manual or computer control, making it possible to collect data in several orientations as needed for tomographic image reconstruction; an electronics system composed by a front-end electronics system, located physically on the detector heads, and a trigger and data acquisition system located off-detector in an electronic crate; a data acquisition and control software; and an image reconstruction and analysis software that allows reconstructing, visualizing and analyzing the data produced during the examination.

In a medical imaging system including plural imaging section, detection accuracy and examination efficiency for breast cancer are improved by setting appropriate imaging condition. The system includes: a first imaging section for imaging an object to be inspected by using one of radiation, ultrasonic waves, nuclear magnetic resonance, positron, infrared light and fluorescence to generate a medical image; a second imaging section for imaging the object by using another one of radiation, ultrasonic waves, nuclear magnetic resonance, positron, infrared light and fluorescence to generate a medical image; and an imaging condition setting section for setting imaging condition in the second imaging section based on the medical image generated by the first imaging section.

The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment. The method comprises: providing a micro reactor; introducing a liquid reactive precursor dissolved in a polar aprotic solvent into an inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; introducing a solution comprising a radioactive isotope dissolved in a polar aprotic solvent into another inlet port of the micro reactor; contacting the reactive precursor with the isotope-containing solution in a microchannel of the micro reactor; reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, wherein the reacting step is conducted at a temperature above the boiling point of the polar aprotic solvent at 1 atm and at a pressure sufficient to maintain the polar aprotic solvent in liquid form; and collecting the resulting radiochemical from the micro reactor.

Method and apparatus for real-time tracking of a target in a human body. In one embodiment of the invention, positron emission marker may be implanted into a target, the positron emission marker having a low activity positron isotope. In one embodiment, annihilation gamma rays associated with the low activity positron isotope may be detected using a plurality of position-sensitive detectors. In another embodiment, the target may be tracked in real-time based on a position of the positron emission marker.

A mobile PET scanner for use in bed side or a surgical environment comprises a mobile support base, with first and a second arm arms extending therefrom. The first arm is configured for placement under a table supporting an individual while the second arm is substantially parallel to and above said first arm with the individual being located between the first and second arms. Multiple module blocks are positioned along the length of the first and second arm. Each modules block comprises scintillators with solid state silicone multipliers or multi-pixel photon counters attached thereto. Positrons emitted from radiation labeled tissue within the individual's body impinge on the multiple scintillators to generate. The photons from each of the scintillator are received by each of a solid state silicone multipliers or multi-pixel photon counters associated therewith and an electrical signal representative of the received photons is then generated. The electrical signal output from each of the solid state silicone multipliers or multi-pixel photon counters is then transmitted to a computerized data collection and analysis system, which substantially instantaneously generates a visual image on a screen showing the location within the individuals body emitted the photons. This image can be coordinated with a photo image or a CT image showing the same portion of the individual's body.

The invention relates to the medical slice imaging and nuclear-imaging field, in particular to a first-group board card, a signal buffering unit, a second-group receiving board card, a data buffering unit, a reference clock 17, a clock adjusting unit and an on-site programmable gate array that are used for a conforming system in a positron slice scanning device; the method is characterized in that the on-site programmable gate array is utilized to judge the time, the position and the energy among all matters, and two matters that pass through the judging and selecting regulations form a conforming case. By inducting the on-site programmable gate array, the case information captured by a front-end detector module of a PET apparatus can be processed fast and high-efficiently by compiling hardware description language, so as to ensure whether the conforming matters happen or not. The method is an improvement of the process of the prior PET conforming system. The method can finish the process of the conforming system high-efficiently and fast by using a piece of FPGA and can lead the system not to be inducted into the dead time while the high system sensitivity is obtained.

The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

Image quality deterioration due to a drop in resolution or lowering of S/N ratio while reducing the amount of data stored during a 3D data acquisition process, and shortening the time from the start of an examination to the end of imaging. The method and apparatus of this invention perform, in parallel with the 3D data acquisition process, addition of sinograms, reading of subsets of the sinograms having been added, and image reconstruction. Consequently, the amount of data stored is reduced, and the time from the start of an examination to the end of imaging is shortened. At the same time, since 3D iterative reconstruction is not accompanied by conversion from 3D data to 2D data, a drop in resolution due to errors occurring with the conversion from 3D data to 2D data is avoided. The 3D iterative reconstruction can directly incorporate processes such as an attenuation correction process. It is thus possible to avoid also a lowering of S/N ratio resulting from an indirect incorporation of such processes.

Non-destructive testing apparatus may comprise a photon source and a source material that emits positrons in response to bombardment of the source material with photons. The source material is positionable adjacent the photon source and a specimen so that when the source material is positioned adjacent the photon source it is exposed to photons produced thereby. When the source material is positioned adjacent the specimen, the specimen is exposed to at least some of the positrons emitted by the source material. A detector system positioned adjacent the specimen detects annihilation gamma rays emitted by the specimen. Another embodiment comprises a neutron source and a source material that emits positrons in response to neutron bombardment.

Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as ⁶⁴Cu, ¹²⁵I (SPECT) and ^99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.

A patient imaging system includes a patient support table, an MRI system including a cylindrical magnet and a PET system including positron detectors mounted in a ring. The magnet defines a cylindrical bore for receiving the patient on the table where the magnet is mounted for rotation about a vertical axis on a slew ring carried on rails allowing longitudinal movement. The PET ring is mounted in the bore for longitudinal movement. The quench tube for the magnet passes through the slew ring with a rotary union at the axis. The shielding covers include a fixed upper part and a lower part which rotates about the axis with the magnet. The magnet is arranged in a two or three room diagnostic configuration in which a holding bay houses the magnet and the diagnostic patients are organized in the three rooms each cooperating with the magnet bay as the magnet is rotated.

The invention relates to a positron emission tomography scanner and a conformity judgment and selection method. The scanner comprises a plurality of detectors. The method comprises the following steps: acquiring instance information of each detector; storing the instance information in the corresponding storage space; taking the time information of each instance information as address information of the storage space; acquiring a plurality of sign information according to each instance information, wherein each sign information shows times of detecting gamma photons in corresponding time; acquiring judgment and selection information according to each sign information, wherein the judgment and selection information represents the times of detecting the gamma photons in a preset conformed time window from the corresponding time information; ranking each judgment and selection according to the corresponding time information; checking the ranked judgment and selection information by utilizing sequence checking features in sequence; identifying the storage space that the conformed instance corresponds to; and outputting the instance information in the storage space that the conformed instance corresponds to. The positron emission tomography scanner and the conformity judgment and selection method provided by the invention have the advantages of rapid and efficient conformity judgment and selection and wide application range.

The invention relates to a detector arrangement (21) for a tomographic imaging apparatus, particularly for a positron emission tomograph. The detector arrangement (21) according to the invention includes at least two sandwiched pairs of a scintillator (22-24) and an associated photodetector (25-27), wherein the pairs are sandwiched along a direction of detection.

Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.

The invention discloses Al18F-NOTA-PEG6-TATE of a targeted somatostatin receptor and a preparation method and application of Al18F-NOTA-PEG6-TATE. The preparation method of the label includes the steps that a somatostatin derivative TATE and a difunctional chelating agent NOTA are connected through PEG to generate a radiolabelled precursor, then positron nuclide 18F labeling is carried out through a one-pot method, and the 18F labeled somatostatin derivative Al18F-NOTA-PEG6-TATE can be obtained. The method can be carried out in an acetate buffer solution system or an acetonitrile reaction system, and the method has the advantages of being easy and convenient to operate and high in labeling rate and product purity. The prepared positron label of the targeted somatostatin receptor can be applied to preparation of a PET/CT molecular probe or tumor therapy medicine, and provides a novel thought for synthesis of the clinical PET/CT molecular probe.