24 results about "Positron" patented technology

This invention relates to a convolution-based method for noise suppression in positron emission tomography (PET) flow field images, comprising the following steps: S1, obtaining consistent data through CFD flow field simulation and GATE detection system simulation, and reconstructing a low-resolution initial image of the PET flow field containing noise using the OSEM algorithm; S2, constructing a noise suppressor model, inputting the low-resolution initial image into the model, and outputting a noise-suppressed flow field feature image using a deep convolutional network and multi-scale feature fusion technology; S3, constructing a multi-loss fusion evaluation system, using mean squared error loss, minimum absolute value deviation loss, and perceptual loss to jointly constrain model training, and iteratively updating the weights using the Adam optimizer. This invention not only improves the enhancement model's ability to distinguish noise information, thereby enhancing the model's ability to remove noise information from PET images, but also significantly improves evaluation metrics such as PSNR and SSIM.

A method for determining a convolution kernel for an iterative statistical algorithm based on a continuous-to-continuous data model. The method is used for image reconstruction from radiation measurements obtained in emission tomography, specifically in a Time-of-Flight Positron Emission Tomography (TOF PET) scanner. The presented method is a non-list-mode solution that reduces the computational complexity of the reconstruction problem, improves the resolution of reconstructed images, reduces the radiation dose absorbed by patients during TOF PET examinations, and / or shortens the measurement acquisition time without significantly compromising the quality of the diagnostic images. Notably, the quality of the functional images remains at the same level. These improvements are achieved by designing the convolution kernel to account for the statistical properties of the measurement signals registered during the TOF PET scanner's acquisition process.

The application provides a simulation prediction method and system for slow positron source intensity in a research reactor, comprising the following steps: S1, reading arrangement information of components in a reactor core of the research reactor; S2, constructing a Monte Carlo model of the reactor core containing a slow positron source device, and obtaining neutron multi-group angular flux and photon multi-group angular flux information near the slow positron source generating device; S3, constructing a slow positron Monte Carlo model; S4, performing energy-angle double sampling to obtain an incident neutron energy probability density distribution function f n,ig,ia , an angle probability density distribution function f n,ia , an incident photon flux energy probability density distribution function f g,ig,ia , an angle probability density distribution function f g,ia , and a neutron-photon weight factor; S5, performing function sampling of particle types, energy and angle; and S6, obtaining slow positron distribution information generated in the slow positron generating device. The application accurately considers the whole life cycle of slow positron generation and transportation through multi-stage coupling, and realizes accurate prediction of slow positron source intensity.

The present invention facilitates manufacturing of a scintillator array, a radiation detection device, and a positron emission tomography device. A scintillator array (11) is provided with at least one pair of scintillators (11Uia, 11Uib), a light reflection member (LA) disposed in a first location between the scintillators for preventing light from passing between the scintillators, and an air layer (LB) disposed in a second location between the scintillators for allowing light to pass between the scintillators.

A kind of slow positron source of pile base, control method and reactor belong to nuclear power field.The slow positron source of pile base includes slow positron generating component, outer sleeve, heavy water tank sleeve and sealing component;Heavy water tank sleeve is connected into heavy water tank, outer sleeve is inserted into heavy water tank by heavy water tank sleeve and makes end submerged in heavy water;Slow positron generating component is arranged at the end of outer sleeve and is enclosed in outer sleeve;Sealing component includes heavy water sealing mechanism and light water sealing mechanism, heavy water sealing mechanism encloses the gap between heavy water tank sleeve and outer sleeve, and light water sealing mechanism encloses the gap in pool wall sleeve.The slow positron source of pile base can utilize heavy water convection to cool slow positron generating component, effectively improve heat dissipation efficiency, and improve slow positron beam intensity upper limit.

The purpose of this beam source is to develop a positron microbeam, making it the first attempt to describe e + As a beam / current for pumping / injecting semiconductor devices. Furthermore, Type I: Positron beams possess high energy (up to hundreds of keV or even tens of MeV), but their range should follow the same limits as electrons, since electrons can be converted into positrons, both of which can be used as sources for pumping materials. This will prevent the formation of defects in positron-pumped materials, which would otherwise cause rapid degradation of material properties. Type II: The conversion to Weyl fermions, which are thought to carry charge through devices much faster than ordinary electrons. According to recent research, Weyl electrons carry current at least twice as fast as graphene electrons and at least 1000 times faster than electrons in ordinary semiconductors. This patent aims to advance research in this field by utilizing Weyl electrons as a beam / current for pumping / injecting semiconductor devices.

The present disclosure is related to systems and methods for data masking. The method includes obtaining data associated with coincidence events related to intrinsic background radiations of a plurality of crystals of the PET device. Each of the coincidence events may be detected by two crystals of the plurality of crystals of the PET device. The data associated with the each coincidence event may include first time information and second time information. The method includes determining a first time of fight (TOF) difference corresponding to the each coincidence event based on the first time information and the second time information. The method includes determining a second TOF difference corresponding to the each coincidence event based on locations of the two crystals that detect the each coincidence event. The method includes correcting the PET device based on the first TOF difference and the second TOF difference.

A method for determining a convolution kernel for an iterative statistical algorithm based on a continuous-to-continuous data model for image reconstruction from radiation measurements obtained in emission tomography, specifically in a Positron Emission Tomography (PET) scanner. The method improves the resolution of reconstructed images, reduces the radiation dose absorbed by patients during PET examinations, and / or shortens the measurement acquisition time without significant loss in the quality of the diagnostic images obtained. Specifically, the quality of the functional images remains at the same level. These improvements are achieved through the design of the convolution kernel, which takes into account the statistical properties of the measurement signals registered during the acquisition process in the PET scanner.

Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor-1 receptors in subjects suffering from or suspected of suffering from a neuroinflammatory or neurodegenerative disease or disorder are disclosed.

This invention provides a dose prediction system, dose prediction method, and dose prediction program for accurately evaluating particle beam irradiation doses and supporting treatment using particle beams. [Solution] The support device 20 comprises an irradiation device 31 that irradiates with a particle beam, a detection device 32 that measures the irradiation area of ​​the particle beam, an imaging device 33 that photographs the light emission of the irradiation area, and a control unit 21 that predicts the irradiation dose by the irradiation device 31. The control unit 21 acquires the light emission distribution of the surface of the irradiated object irradiated with the particle beam, acquires the activity distribution of positron emission nuclei generated on the side surface of the irradiated object, and calculates a three-dimensional dose distribution using the light emission distribution and the activity distribution.

Systems and methods for estimating mean randomness include: acquiring list pattern data describing true and delayed coincidences detected by a positron emission tomography (PET) scanner during a scan of an object; determining, based on the list pattern data, delayed coincidences including said crystals for each crystal of the PET scanner and for each of a plurality of time periods of the scan; for each crystal, determining a single event rate associated with each time period based on the delayed coincidences determined for the crystal within the time period; for each time period, determining an estimated mean randomness for each of a plurality of crystal pairs based on the single event rate associated with the time period for each crystal of the crystal pair; and reconstructing an image of the object based on the estimated mean randomness for each time period and the detected true coincidences.

This specification relates to a method, apparatus, and device for reconstructing PET images. The method includes: acquiring a positron emission tomography (PET) image to be reconstructed; inputting the PET image into a pre-trained degradation pattern recognition model to obtain degradation pattern information of the PET image; inputting the PET image and the degradation pattern information into a pre-trained reconstruction model to obtain a reconstructed PET image; wherein the reconstruction model uses the degradation pattern information as prior information to predict and remove degradation components of the PET image. By identifying and utilizing degradation pattern information, the reconstruction model can achieve reconstruction quality no less than that of multimodal fusion methods using only single-modal PET data. This fundamentally avoids registration errors and significantly reduces patient radiation exposure and examination costs.

Systems and methods for a time of flight (TOF) positron emission tomography (PET) system is herein provided. In one example, an imaging system comprises one or more detector blocks, each detector block including an array of silicon photomultiplier (SiPM) devices coupled to an array of scintillation crystals with a one-to-one coupling arrangement, wherein each SiPM device of the array of SiPM devices transmits signals to independent front-end readout circuits of one or more analog application-specific integrated circuits (ASICs). The front-end readout circuits are configured to detect individual scintillating photons and suppress SiPM dark counts.

The invention provides a method of preparing a 89Zr-oxine complex of the formulaThe invention also provides a method of labeling a cell with the 89Zr-oxine complex and a method for detecting a biological cell in a subject comprising administering the 89Zr-oxine complex to the subject.

A time-of-flight positron emission tomography (TOFPET) assembly for detecting lesions of a breast of a subject, wherein the subject may anatomically be defined with a median plane and chest wall-coronal plane. The assembly may comprise: a detector array having at least two or more detector segments. The detector segments may include: a scintillator for placement toward the target, the scintillator having a top edge generally closest to the subject and a detection surface wall aligned closest to surrounding the breast, a photo multiplier opposite the scintillator, and a readout connected to the photo multiplier. The assembly may also comprise a processor that receives the acquired tracer emission signals and converts the signals into a three dimensional, tomographic image reconstruction. The detector array is defined by a ring surrounding the breast and the face of ring that may be tilted to offset the chest wall-coronal plane of the subject, and wherein one of the top edges of one of the detector segments is above the chest wall-coronal plane of the subject in the posterior direction.

The present invention relates to new and inventive compounds of formula (I). The compounds are useful as PET (positron emission tomography) tracer.

The subject of the application is a measuring cell for testing liquids using positron lifetime spectroscopy, characterized in that it consists of two modules: a mounting module and a measuring cell body module. The mounting module for a radioactive source (18) — preferably in the shape of a cuboid with a through hole or a ring, most preferably in the shape of a toroid with a rectangular cross-section — consists of: a mounting base (2) with a keyway and socket, and a (thinner) mounting cover (9) with a tongue and flange. The mounting base (2) has at least one filling opening in the outer surface of the base, which communicates with at least one through filling channel, which has an outlet in the inner surface of the base or in the inner surface of the cover (9).The inner surface of the fixture module—that is, the fixture base and the fixture cover—constitutes the boundary of the through-hole, with the base filling channel or the cover filling channel forming an extension of the filling hole. Furthermore, the base (2) and the cover (9) form a detachable keyway connection, while the keyway is a recess, preferably annular, that fits the projection of the cover (9), forming a socket for the projection. The fixture cover (9) consists of the projection and the flange. The projection has an outer diameter smaller than the outer diameter of the flange, preferably forming a collar sleeve shape, which fits the projection socket and covers the fixture base (2). The measuring cell body module, preferably has a cuboid shape—it consists of a measuring cell body base (20) with a keyway and a socket for the fixture module, and a body cover (30) with a projection and a socket for the fixture module, forming a keyway connection.The base of the body (20) of the measuring cell preferably has the shape of a cuboid, with a rectangular cross-section, and a recess in the center, shaped to fit the housing module, preferably in a cuboid or cylindrical shape, which forms a socket for the housing module. Additionally, the base of the body (20) in the socket recess also has a key, preferably in the shape of a ring, which surrounds the housing module socket, creating an annular recess that fits the projection of the cover (30).The body base (20) has at least three through holes for the pressure screw, located in at least three vertices of the body base (20). Furthermore, a threaded through hole for the sealing screw is located in the outer surface of the base. Preferably, the axis of the sealing screw hole is perpendicular to the design axis (X) of the measuring cell and passes through a point defining half the height and width of the outer surface of the body module, wherein the axis of the sealing screw hole is extended in a U-shaped threaded recess for the sealing screw located across the groove. The design axis (X) is identical to the axis of symmetry of the socket for the housing module. The (thinner) cover of the body (30) preferably has the shape of a cuboid, with a rectangular cross-section, and has a projection that matches the shape of both the groove in the body base (20) and is adapted to accommodate the housing module inside, creating a centering socket.Furthermore, a U-shaped recess for a sealing screw is located across the projection, preferably with the axis of the recess perpendicular to the design axis (X) of the measuring cell. The housing cover (30) has at least three through holes for the pressure screw, located in at least three vertices of the cover (30). The pressure screw holes in the cover (30) are matched in location and diameter to the location of the pressure screw holes in the housing base (20).

According to various aspects of this disclosure, the present disclosure relates to an automated process for the radiosynthesis of [18F]FSPG, a positron emission tracer. The automated optimized process of the present invention enables the centralized and large-scale production of [18F]FSPG for commercial use.

This invention proposes a method and system for acquiring real-time ionospheric information using GNSS based on forecast variance, relating to the field of GNSS positioning technology. The method includes: acquiring real-time ionospheric data from multiple different analysis centers and preprocessing it to obtain corresponding spherical harmonic coefficients; converting the spherical harmonic coefficients into the total electron content at the corresponding ionospheric puncture point using a spherical harmonic function, correcting the total electron content at different puncture points using solar position information to obtain corrected electron content data, and converting the corrected electron content data into global VTEC grid data; using the electron content forecast information released by the European Orbit Determination Centre as the true value and the global VTEC grid data as the observed value, calculating the data weight value for each analysis center; and weighting and fusing the global VTEC grid data corresponding to each analysis center using the data weight value to obtain the target ionospheric electron total quantity information.

The application discloses a kind of near-infrared fluorescence / positron emission tomography bimodal molecular imaging probe NIR-[ 68 Ga] and preparation method and application thereof, and the application is by the specific response of alzheimer disease beta amyloid monomer, oligomer and aggregate near-infrared fluorescent small molecule probe on radionuclide 68 Ga 3+ Labeling, obtain near-infrared fluorescence / positron emission tomography bimodal molecular imaging probe NIR-[ 68 Ga], to be applied to the bimodal imaging detection of AD A beta protein, especially early soluble A beta protein monomer and oligomer, to improve the sensitivity and accuracy of A beta protein on living body detection, to realize the early accurate diagnosis of AD.