158 results about "Photon emission" patented technology

Presented herein are systems and methods that provide for improved detection and characterization of lesions within a subject via automated analysis of nuclear medicine images, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) images. In particular, in certain embodiments, the approaches described herein leverage artificial intelligence (AI) to detect regions of 3D nuclear medicine images corresponding to hotspots that represent potential cancerous lesions in the subject. The machine learning modules may be used not only to detect presence and locations of such regions within an image, but also to segment the region corresponding to the lesion and / or classify such hotspots based on the likelihood that they are indicative of a true, underlying cancerous lesion. This AI-based lesion detection, segmentation, and classification can provide a basis for further characterization of lesions, overall tumor burden, and estimation of disease severity and risk.

The invention relates to a microscope system, in particular to a confocal microscope system of a short-wave infrared band. The system comprises a bright / dark field microscopy subsystem, a photon emission microscopy subsystem, a short wave infrared laser scanning confocal microscopy subsystem, a fluorescence confocal microscopy subsystem and a control module. According to the system provided by the invention, the short-wave infrared fluorescence lifetime curve can be obtained through the electro-luminescence emission and / or photoluminescence emission of the semiconductor device in the integrated circuit, so that the defect type of the semiconductor can be judged. Besides, the system adopts a multi-subsystem optical path multiplexing structure in structural design, short-wave infrared fluorescence generated by exciting a defect or a failure point is collected while observation is facilitated, high integration level is achieved, and observation, positioning and failure analysis of the defect or the failure point can be achieved only by using a single system provided by the invention.

This disclosure provides systems, methods and apparatuses for single photon emitters based on nanoribbons. A single photon emitter includes: a substrate; at least one nanostructure disposed on the substrate; and a nanoribbon disposed over at least one apex of the at least one nanostructure. The nanoribbon may include a transition metal dichalcogenide (TMD). A method of manufacturing a single photon emitter includes: growing a transition metal dichalcogenide (TMD) nanoribbon on a first substrate; collecting the TMD nanoribbon on a polymer film; stacking the TMD nanoribbon and polymer film on a second substrate having nanostructures with the TMD nanoribbon disposed over an apex of the at least one nanostructure; and removing the polymer film.

A back illuminated sensor is included as a collector component of a detector for use in intraoral and extraoral 2D and 3D dental radiography, digital tomosynthesis, photon-counting computed tomography, positron emission tomography (PET), and single-photon emission computed tomography (SPECT). The disclosed imaging method includes one or more intraoral or extraoral emitters for emitting a low-dose gamma ray or x-ray beam through an examination area; and one or more intraoral or extraoral detectors for receiving the beam, each detector including a back illuminated sensor. Within the detector, the beam is converted into light and then focused and collected at a photocathode layer without passing through the wiring layer of the back illuminated sensor.

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Disclosed in the present application are an HCT prediction method and system, a device, and a medium. Photons in a photon group are emitted into an extracorporeal circulation blood model so that the photons are reflected, scattered, or absorbed during movement. The extracorporeal circulation blood model is a model constructed on the basis of the thickness of an extracorporeal circulation tube, the thickness of the blood, and the distance from a light source generator to a detector. Light intensity data corresponding to photons reaching the detector are acquired. The acquired light intensity data are input into a prediction model to obtain a hematocrit (HCT) prediction value. The prediction model is a model constructed on the basis of a BP neural network and the relationship between light intensity and HCT. The prediction model combining simulation and neural network increases the data volume, achieves continuous non-invasive estimation of HCT by means of algorithm model optimization, and improves the accuracy of HCT prediction.

A computer-implemented method is provided for improving image quality. The method comprises: (a) acquiring, using single-photon emission computed tomography (SPECT), a first medical image of a subject, the first medical image is acquired with an acceleration scheme; (b) combining the medical image with a second medical image acquired using computed tomography (CT) to generate an input image; and selecting a deep learning network model to apply to the input image based at least in part on the acceleration scheme and outputting an enhanced medical image.

The present invention relates to triglyceride analogs labeled with radioisotopes, or salts thereof, for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging. In addition, the present invention relates to compositions comprising the radiolabeled triglyceride analog, or a salt thereof, and methods for preparing the same. Further, methods of imaging using the radiolabeled triglyceride analog and uses of the radiolabeled triglyceride analog are disclosed herein. The invention also relates to an intermediate triglyceride analog for synthesis of the radiolabeled triglyceride analog.

The application provides a photomultiplier tube and a detector. The photomultiplier tube comprises: a photocathode configured to receive photons and emit photoelectrons based on the received photons; a photomultiplication system located downstream of the photocathode and arranged around a target axis, the target axis coinciding with or being parallel to a central axis of the photomultiplier tube, the photomultiplication system configured to receive the photoelectrons emitted by the photocathode and multiply the photoelectrons; and an anode configured to collect the photoelectrons multiplied by the photomultiplication system and output an anode current based on the collected photoelectrons. According to the embodiments of the application, the carrying capacity of each stage of the multiplication electrode is increased, thereby improving the pulse width response range of the photomultiplier tube and the linear current of the photomultiplier tube.

The invention discloses a fluorescent bead multi-photon property measuring device which is characterized in that a laser signal with a preset first wavelength is generated through an optical fiber laser, and a photonic crystal fiber converts the laser signal into a high-energy soliton laser signal with a preset second wavelength (in a target wave band range); then the high-energy soliton laser signal is accurately focused on a fluorescent bead sample through an optical focusing assembly, the fluorescent bead sample is effectively excited to generate a corresponding three-photon fluorescent signal, and finally a microscopic image and a three-photon emission spectrum of the fluorescent bead are obtained at the same time in combination with a microscopic imaging assembly and a spectrograph. Therefore, comprehensive measurement of the multi-photon properties of the fluorescent beads can be efficiently and accurately realized, and the measurement effectiveness and efficiency are improved. Besides, the device can also measure the multi-photon order and the relative multi-photon cross section of the fluorescent bead, and evaluates the photobleaching behavior and the light stability of the fluorescent bead in combination with the dynamic monitoring of the fluorescent signal along with time, thereby making up the defects of the related technology in the measurement of the multi-photon property of the fluorescent bead at the wave band of 1700nm.

The invention belongs to the technical field of inorganic scintillator materials, and particularly relates to a multi-element co-doped yttrium lutetium silicate scintillator and a preparation method and application thereof, and the material has excellent comprehensive performance of high light output, short decay time, high radiation hardness, high matching degree of emission spectrum and novel photoelectric sensors and the like. The invention further relates to a preparation method of the scintillator material and application of the scintillator material in radiation detection fields such as positron emission tomography (PET), time flight PET (TOF-PET), interaction depth PET (DOI-PET), single photon emission computed tomography (SPECT), high-energy physical experiments, nuclear medicine imaging, industrial nondestructive inspection, safety detection (such as luggage and cargo container inspection) and the like.

The disclosure concerns a method for manufacturing a photon emitter for the emission of photons including at least one insulator layer, one thin film layer and at least one waveguide positioned in the thin film layer, with the following method steps: providing the insulator layer; providing the thin film layer including a predetermined thin film layer thickness; positioning of the thin film layer on the insulator layer, such that the thin film layer lies flat on the insulator layer; determining a waveguide width of the minimum of one waveguide in the thin film layer, wherein the waveguide width is selected according to the predetermined thin film layer thickness such that the photons exhibit a predetermined property; generating the minimum of one waveguide in the thin film layer, wherein the waveguide exhibits the specific waveguide width.

The present invention relates to a method and an apparatus for attenuation correction of myocardial perfusion single-photon emission computed tomography (MPS) image data, the method comprising the steps of: receiving multiple pieces of MPS image data; generating a data set including a first set and a second set by using the MPS image data; applying multiple pieces of image data included in the data set to a deep learning algorithm using multiple loss functions so as to train the deep learning algorithm; generating attenuation-corrected (generated attenuation-corrected (GEN AC )) image data by applying the multiple pieces of image data and the MPS image data to the trained deep learning algorithm; and evaluating the clinical applicability of the generated attenuation-corrected image data. The present invention can also be applied to other embodiments.

Reducing noise and dose (radiation or contrast) for perfusion imaging in Computed Tomography Perfusion (CTP), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI) medical scanning devices by using a k-space based method. The time sequence of images from the scanner data set is converted as necessary, such as using a 2D Fast Fourier Transform (FFT), into a k-space having multiple timeframes. View-shared averaging is performed to reduce noise and preserve spatial and temporal resolutions of CTP, PET, SPECT and MRI data by progressively increasing the number of time frames for view-shared averaging for more distant regions of “k-space”, before converting the data, such as through a 2D FFT into a time sequence of noise reduced images.

The invention relates to a method for the temporal synchronization of detection events of two receivers for quantum communication, preferably for quantum key exchange (QKD), comprising the generation of entangled photon pairs in a source, transmission of one individual photon of each entangled photon pair to each receiver, detection of the individual photons at each receiver and storage of the detection events, and the temporal synchronization of the detection events of the two receivers, preferably for quantum key exchange (QKD). Essentially, during the generation of the entangled photon pairs for the temporal synchronization of the detection events of the two receivers, the emission rate of the individual photons of the entangled photon pairs in the source is changed over a time interval Δtmod, and the change in the emission rate of the individual photons is detected at both receivers for the purpose of synchronizing the detection events.

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source for calibrating a SPECT system comprises a radioactive material aligned along a central axis of the collimated line source and a plurality of collimator plates arranged perpendicularly around the central axis, the collimator plates including a material that substantially absorbs photons striking the collimator plates. The collimator plates may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system, thereby reducing an amount of radiation released in an environment of the SPECT imaging system during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

The invention discloses a mechanoluminescence efficiency testing device and method based on an integrating sphere, and the device comprises a standard light source which is used for generating a standard light signal; the integrating sphere is used for collecting optical signals generated by the standard light source and the test sample; the test sample is an elastic film with mechanoluminescence performance, and mechanoluminescence is realized through stretching; the optical fiber spectrometer is used for converting an optical signal output from the integrating sphere into a digital signal; the mechanical load applying device is used for applying tensile acting force to the test sample, so that the test sample is deformed to generate photon emission; in the first working state, the standard light source is arranged in front of the integrating sphere; in the second working state, the standard light source is removed, the test sample is tightly attached right in front of the light inlet hole of the integrating sphere, and the mechanical load applying device is used for applying tensile acting force to the test sample. The mechanoluminescence efficiency testing device and the mechanoluminescence efficiency testing method provided by the invention have universality, and are applicable to different mechanoluminescence materials with stretchability.

A computer system and method for providing single-photon emission tomography (SPECT) uptake data. A processor of the computer system is caused to receive SPECT data obtained from a SPECT acquisition, and quantify regional activity uptake of at least one isotope of a plurality of isotopes.

A quantum computing system, method and computer readable medium involve a vacuum enclosure for sustaining a vacuum below 10−3 millibar, an optical resonator tuned to a resonance of an atom, and a trapping laser for maintaining the atom within a mode of the optical resonator. An atom excitation laser induces emissions of photons, at least one of a plurality of waveguides couples the photons to or from the optical resonator, and a detector associated with at least one of the plurality of waveguides detects at least some of the emitted photons. A processor controls optical switches for switching between two or more of the plurality of waveguides.

The present invention provides a closed loop generation and / or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and / or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject; wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score; and wherein the analysis of the one or more images is performed by using an automated system.

A frequency-tunable coupler (130) couples first and second quantum systems (110, 120), the coupler (130) and the second quantum system (120) being arranged so that tuning the coupler (130) to the second quantum system (120) forms a hybridized mode with a symmetric state and an asymmetric state, coupled to a waveguide (140) The coupler (130) is driven with an excitation-preserving transition signal to transfer a first excited state of the first quantum system (110) to the asymmetric state of the hybridized mode, thereby emitting a photon encoded with a first part of a quantum state into the waveguide at a first frequency. The first quantum system (110) is simultaneously driven with a non-excitation-preserving transition signal to transfer a second excited state of the first quantum system (110) to the symmetric state of the hybridized mode, thereby emitting a second photon encoded with a second part of the quantum state, at a second frequency.

An integrated circuit (IC) comprises a resistive switching section (1) with an active layer (14) arranged between a first electrode (11) and a second electrode (12), wherein the resistive switching section (1) is configured: —to provide an electrical resistance between the first and second electrode (11, 12) which is switchable between different resistance values (LR, HR) depending on an electrical signal (U, I) applied to the first and the second electrode (11, 12), and—to emit photons (15) during or associated with switching between the resistance values (LR, HR).

The present invention concerns a system for generating quantum keys between two nodes of an optical communication network. The system comprises a transmitting node and a receiving node, operationally connected to each other by at least one birefringent optical communication channel. The transmitting node comprises a photon source, an optical port adapted to transmit and receive photons on the optical communication channel, a detector assembly adapted to detect and count photons received from the receiving node. The receiving node comprises an optical port for receiving and transmitting photons on the optical communication channel, and a photon emitter adapted to emit at least one photon in response to the at least one photon transmitted by the transmitting node. The photon emitter comprises at least one birefringent element. Advantageously, the receiving node comprises control means of the photon emitter. The control means are adapted to adjust a birefringence of the at least one birefringent element as a function of polarization information associated with the at least one photon transmitted by the transmitting node. In particular, the polarization information is extracted from the at least one photon transmitted by the transmitting node or is provided by the transmitting node. Advantageously, the photon emitter comprises an emulator device of a Faraday rotator mirror or comprises a retroreflector consisting of three mirrors orthogonal to each other and rotated by 45° around respective orthogonal axes. The Faraday rotator mirror and the retroreflector are orientable in space to reflect the at least one photon transmitted by the transmitting node uniquely and determined when oriented appropriately.

The invention discloses a strong pumping bilateral resonance modulation-demodulation magnetic sensitivity enhancement method of a quantum magnetic compass. The method comprises the following steps: constructing a quantum magnetic compass platform comprising a sensing unit and external optical and microelectronic devices; quantum state enhanced reading containing magnetic vector information is realized by using a pumping enhancement mode; a standard diamond is used, the thermal conductivity and the light transmission of the diamond are utilized, the initialization of a quantum state is realized by using near-saturation external pump light, the line width is narrowed, and the magnetic measurement sensitivity is improved; noise in the environment is filtered out in a modulation and demodulation mode, and high-robustness extraction of quantum information is achieved. By enhancing the laser pumping power, the emission speed of the solid-state quantum color center ensemble fluorescence photons is increased, the full width at half maximum of a magnetic resonance curve is compressed, and the measuring capacity of the solid-state quantum color center to a magnetic field is improved; accurate measurement of external magnetic field signals through the solid quantum color center in the diamond is realized.

This specification discloses devices, methods for manufacturing the same, and methods for using the same. For example, this specification discloses a device comprising a first contact layer, a semiconductor layer comprising a semiconductor material having a first bandgap, and a dielectric layer comprising a dielectric material, wherein the first contact layer is located on and in physical contact with the dielectric layer, and the dielectric layer is located on and in physical contact with the semiconductor layer, thereby sandwiching the dielectric layer between both the first contact layer and the semiconductor layer and being in physical contact with both, and the dielectric layer suppresses the photon emission of carriers between the first contact layer and the semiconductor layer under incident light. This specification also discloses methods for using any of the devices disclosed herein. In some examples, the methods include using the device as a solar blind photodetector.

A system for low-count quantitative single-photon emission computed tomography (LC-QSPECT) is provided. The system is programmed to a) store a computer tomography (CT) scan of a subject being examining including a plurality of defined volumes of interest (VOIs) of the subject being examined; b) model a system matrix based on the stored CT, wherein the model describes the probability that photons emitted from each of the defined VOIs are detected in different projection bins, wherein a plurality of projection bins are defined around the subject and the defined VOIs; c) adjust the model with analysis of stray-radiation noise around the subject; d) detect, by the one or more sensors, one or more photons being emitted by an alpha-particle-emitting isotope; and e) execute the adjusted model with the one or more detected photons as inputs to determine a source VOI of the detected photons.

Disclosed are electrically driven single-photon emitters and their fabrication methods. The single-photon emitter comprises a substrate, an active layer on the substrate, a spacer between the substrate and the active layer, a first electrode connected to the active layer, and a second electrode between the substrate and the spacer and vertically spaced apart from the active layer across the spacer. The substrate includes a deformable polymer. The substrate has a first dent where a portion of a top surface of the substrate is concavely recessed. The active layer has a second dent at a position which is aligned with the first dent and where a portion of a top surface of the active layer is concavely recessed.

The present invention provides a compound as represented by formula I or a pharmaceutically acceptable salt, precursor compound, isotope compound, stereoisomer or tautomer thereof. The compound has high affinity and strong targeting specificity for melanoma, low non-specific uptake in livers and kidneys, and a high tumor / non-tumor ratio. In addition, the probe precursor of the present invention can selectively chelate different radioactive diagnostic or therapeutic nuclides, and is used in single-photon emission computed tomography for early diagnosis of major diseases such as malignant tumors and Parkinson's disease, guiding the selection of a treatment regimen, efficacy monitoring, and radioactive therapy. The compound is simple to synthesize, has easily available raw materials and good stability, and can be promoted and applied as a novel melanoma-targeted radiopharmaceutical.

The invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt thereof, or a precursor compound and an isotope compound thereof, or a stereoisomer and a tautomer thereof. The compound has high affinity with melanoma, strong targeting specificity, low non-specific uptake in liver and kidney, and high tumor / non-tumor ratio. Besides, the probe precursor can be selectively chelated with different radioactive diagnosis or treatment nuclides, and is used for early diagnosis of malignant tumors, Parkinson's diseases and other major diseases through single photon emission computed tomography, and guidance of treatment scheme selection, curative effect monitoring and radioactive treatment. The compound has the advantages of simple synthesis, easily available raw materials and good stability, and can be popularized and applied as a novel melanoma targeted radiopharmaceutical. # imgabs0 #