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Production of Heteromultimeric Proteins

ActiveUS20110287009A1Reduction in yieldDecreased/elimination of effector functionAntipyreticAnalgesicsEpitopeBiochemistry
Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
Owner:F HOFFMANN LA ROCHE & CO AG

Customizable electronic commerce comparison system and method

In a consumer information system, a method of comparing products and services including providing product specific information, providing merchant specific information on the specified product, providing merchant specific business information, providing product specific information collected by third parties, providing merchant specific information collected by third parties, applying weighting factors to the information provided, producing an aggregate value for each merchant based on the weighting factors as applied to the information provided, and producing a ranking of the merchants offering the specified product based on the aggregate value for each merchant. The system provides for consumers to select a set of standardized weighting factors or to modify the standardized weighting factors or to create their own weighting factors. The system provides detailed information to consumers on the breakdown of factors influencing the rating.
Owner:WANKER WILLIAM PAUL

Constant bitrate media encoding techniques

InactiveUS20050015259A1Regulates bitrateSimple processSpeech analysisOne passQuality level
CBR control strategies provide constant or relatively constant bitrate output with variable quality. The control strategies include various techniques and tools, which can be used in combination or independently. For example, an audio encoder uses a trellis in two-pass or delayed-decision CBR encoding. The trellis nodes are states derived by quantizing buffer fullness values. The transitions between nodes of a previous stage and nodes of a current stage depend on encoding a current chunk of audio at different quality levels. When pruning the trellis, the encoder uses a cost function that considers smoothness in quality as well as quality in absolute terms. The encoder may store compressed data at different quality levels, then output the compressed data after simplification of the trellis to a suitable point. If the two-pass or delayed-decision CBR encoding fails, the encoder uses one-pass CBR encoding for the sequence or part of the sequence.
Owner:MICROSOFT TECH LICENSING LLC

Multi-dimensional processor and multi-dimensional audio processor system

InactiveUS6931134B1Increased sonic realityAccurate transfer functionElectrophonic musical instrumentsPseudo-stereo systemsMulti dimensionalAudio frequency
A multi-dimensional audio processor receives as an input either a single channel signal or a two channel signal from an audio signal source; for example a musical instrument or an audio mixer. The processor is programmable to divide the input among at least 3 output channels in a user-defined manner. The processor is also user programmable to provide a variety of effect and mixing functions for the output channel signals.
Owner:WALLER JR JAMES K +2

Wireless mobile device

A wireless Mobile Executive Assistant (MEA) in the form of a PDA/Phone having multiple, independently oriented screens configured to provide data, video independently or in combined fashion. Formed in the opposing first and second edges adjacent to a body having main display screen formed thereon are first and second slots, respectively, the first and second slots formed to receive first and second, slidingly engaging ancillary display screens. Each of the first and second display screens provide independent video or data information from the MEA, or video or other data transmission via the MEA, and can accordingly be used to conference simultaneously with three independent parties on three separate screens. The first and second screens each slidingly engage from a stored position fully with their respective first and second slots, wherein the screens are not discernable to the observer, and the MEA has the appearance of an ordinary cellular-type phone; alternatively, the first and second screens may emanate so that the phone has a first screen emanating from one side, and a second screen emanating generally from the opposite side of the unit, with the main screen situated therebetween. In addition to independent transmissions, all three screens can be deployed to form a single wide screen transmission.
Owner:MICROSITE TECH

Method for forming active pillar of vertical channel transistor

A method for forming an active pillar of a vertical channel transistor includes forming a hard mask pattern on a substrate, etching vertically the substrate using the hard mask pattern as an etch barrier to form an active pillar, and etching horizontally to remove by-product remaining on the exposed substrate, the hard mask pattern and the active pillar and at the same time to reduce line width of the hard mask pattern and the active pillar, wherein a unit cycle in which the vertical etching and the horizontal etching are each performed subsequently once, respectively, is performed repeatedly at least two times or more. According to the present invention, an active pillar having vertical profiles on its sidewalls and having height and line width (or diameter) required in a highly integrated vertical channel transistor can be provided.
Owner:SK HYNIX INC
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