14617 results about "Computational biology" patented technology

The technology described herein relates to systems, methods, and computer storage media, among other things, for providing search query intent specificity. Embodiments may include identifying a search query performed using a search engine and generating a query vector for the search query by aggregating search result embeddings (e.g., item listing vectors) of search results from the search query. Further, in some embodiments, similarities (e.g., cosine similarities) between the query vector and the item listing vectors can be determined. As such, an intent specificity of the search query can be determined. Further, in some embodiments, the intent specificity can be used to train an intent specificity machine learning model for generating intent specificity scores for other search queries. Based on the intent specificity scores determined using the one or more trained intent specificity machine learning models, determinations can be made with respect to precision and recall, etc.

The present disclosure features methods, compositions, and kits for determining the location of a target nucleic acid and / or detecting the presence or absence of a genetic variant in a biological sample using an array with capture probes comprising a spatial barcode and one probe which has complementarity to the capture probe, binds to target and is extended. A second probe which binds to the extended first probe and is extended and bound to capture probe. Location and genetic variant are determined by sequencing of the extended probe.

The present disclosure features methods, compositions, and kits for the spatial detection of genetic variants in a biological sample by using branched ligation.

A federated distributed computational system enables secure biological data analysis and genomic medicine with enhanced oncological therapy capabilities. The system implements patient-specific tumor-on-a-chip analysis through microfluidic control systems and cellular heterogeneity preservation, while integrating fluorescence-enhanced diagnostics using CRISPR-LNP targeting and robotic surgical navigation. The architecture coordinates spatiotemporal analysis of gene therapy delivery through molecular imaging and immune response tracking, and implements bridge RNA integration with multi-target synchronization. Treatment selection is optimized through multi-criteria scoring and patient-specific simulation modeling. Each federated node contains a local processing unit for biological data analysis, privacy preservation protocols, and a hierarchical knowledge graph structure. The system implements cross-species genetic analysis, environmental response modeling, and multi-scale tensor-based data integration, enabling research institutions to collaborate on complex, large-scale biological analyses while maintaining strict data privacy controls.

The invention provides a cross-modal retrieval method for semantic and vector fusion in a data space, which belongs to the field of cross-modal information retrieval, and comprises the following steps: firstly, collecting and preprocessing multi-modal data; generating modal embedding and storing by utilizing the pre-training model; a shared semantic space is constructed, cross-modal vector alignment is optimized through comparative learning, and a modal mapping network is designed to enhance the embedding projection effect; storing the aligned embedding by using a Milvus database, and constructing an HNSW index; user text or image query is processed, text query analyzes limiting conditions to generate enhanced embedding, and image query extracts characters through OCR and fuses the characters with image features to generate embedding; in a database, through condition screening and semantic similarity calculation, a Top-K candidate item is retrieved; performing multi-modal correlation sorting on the candidate results and returning the results; according to the method, the shared semantic space is constructed, the alignment effect of different modal embedding is optimized, efficient storage and index management of multi-modal embedding are carried out, and real-time retrieval of large-scale cross-modal data is achieved.

Provided herein are methods, compositions, and kits to spatially detect genetic variants in a target nucleic acid via templated-ligation and reversible terminator nucleotides.

A multi-source domain adaptive electroencephalogram (EEG) emotional state classification method based on knowledge distillation are provided. First, data is obtained for band-pass filtering, and artifacts are removed by an independent component analysis technology. Second, EEG features are extracted by using a differential entropy method, and a three-dimensional EEG time series is converted into a two-dimensional sample matrix. Then, a training set and a test set are defined in two task scenarios, respectively. A pseudo-label triple loss based on marginal sampling is combined with a maximum mean discrepancy. Knowledge is learned from different source domains, so that a plurality of single-source models are utilized to the greatest extent, and a more powerful model is implemented with less time consumption. Finally, the classification accuracy is used to evaluate the performance of the model in the two task scenarios.

The invention discloses a pulmonary infectious disease prediction system based on multi-modal data fusion, and aims to improve the accuracy and reliability of disease prediction through comprehensive analysis of multi-dimensional data. The system comprises a data acquisition module, a feature extraction module, a dynamic fusion module and a prediction modeling module. The data acquisition module is used for acquiring clinical and medical images and environmental factor data of a patient in real time; the feature extraction module extracts feature vectors of all data sources; the dynamic fusion module performs adaptive weight distribution on the multi-modal features and fuses the multi-modal features into multi-modal feature representation; the prediction modeling module is used for carrying out dynamic change trend modeling on the multi-modal feature representation through time sequence analysis so as to generate a probability prediction value of suffering from pulmonary infectious diseases and a disease trend prediction result of the patient; the invention provides a comprehensive and efficient disease prediction method by utilizing the collaborative advantage of multi-modal data and combining an attention mechanism and time sequence analysis, and can be widely applied to the fields of medical diagnosis and public health management.

Provided herein are methods, kits, and compositions for determining the spatial location of non-coding RNA, such as siRNA and / or miRNA in a biological sample.

Methods and compositions to minimize barcode exchange during the preparation of barcoded next-generation sequencing libraries prepared from a single cell. The methods utilize oligonucleotides containing a 3′-terminated blocking group or sequences that prevent amplification or extension.

Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

Provided herein are methods of identifying genetic variants in biological samples. In particular, the present disclosure uses spatial transcriptomic templated ligation methods and compositions to identify the presence or absence, and the location of genetic variants in the transcriptome or genome of a biological sample.

The invention relates to a drug-disease relationship prediction method and system based on a dual-channel fusion knowledge graph. The method comprises the following steps: S1, constructing a biomedical fusion knowledge graph; s2, constructing a drug-disease sub-graph based on the biomedicine fusion knowledge graph; s3, constructing a dual-channel adaptive fusion feature module, and embedding a drug-disease sub-graph; s4, performing enhanced splicing on the drug-disease sub-graphs in the dual-channel fusion knowledge graph pre-embedded network, importing an edge-node iterative updating learning mechanism, training a spliced sub-graph relation perception learning network, and obtaining enhanced sub-graph feature embedding; and S5, utilizing the trained enhanced subgraph features to embed, calculate and output the prediction probability of the drug-disease relationship. According to the method, the semantic representation capability of the knowledge graph and the topological modeling advantages of the graph neural network are integrated, and efficient and accurate prediction of the drug-disease relationship is realized through multi-modal feature interaction, sub-graph enhancement and a dynamic sub-graph learning mechanism.

The present disclosure relates to the field of biological information, and in particular to a gene regulatory network inference method based on spatiotemporal transcriptomic data, and the use thereof. In the present disclosure, on the basis of a graph neural network, a graph variational auto-encoder is used, an adjacency matrix A is used as node connection information, cells and genes are used as node feature information, and position information of the cells is fully used, so as to reconstruct a feature matrix of nodes by means of three hidden layers, thereby performing more accurate cell clustering and dimensionality reduction analysis while inferring a gene regulatory network.

Provided herein are methods, compositions, and kits to spatially detect genetic variants in a target nucleic acid via templated-ligation and reversible terminator nucleotides.

The invention provides a data consanguinity full-link traceability method and system based on multi-source heterogeneous metadata and a pre-training large model. The method comprises the following steps: S1, collecting metadata and preprocessing the data; s2, identifying the data processed in the S1 by using a data consanguinity detection model, and outputting a consanguinity probability matrix between data entities; s3, filtering the blood relationship probability matrix based on a dynamic threshold value to generate a blood relationship map; and S4, rendering the blood relationship graph obtained in the S3 to visualize the data blood relationship. By means of metadata multi-dimensional feature extraction and end-to-end training of a deep learning large model, the problems that a traditional technology is rigid in rule, low in calculation efficiency, insufficient in semantic understanding and the like are solved, and high-precision and self-adaptive data blood relationship modeling is achieved.

The invention relates to the technical field of data decision, in particular to an analysis decision method for crop growth monitoring data. The method comprises the following steps: collecting crop phenotypic characteristic data through a multi-source sensing array; dynamically dividing crop growth response stages according to phenotypic characteristics; constructing a growth situation prediction model based on the crop growth response stage; inputting the phenotypic characteristic data into a growth situation prediction model, simulating a crop growth process through a digital twin engine, and generating growth situation evolution data; extracting physiological anomaly characteristics of the growth situation evolution data, and generating stress response signals; obtaining a canopy three-dimensional phenotype map based on the stress response signal; positioning vascular bundle nodes of the canopy three-dimensional phenotype map through morphological topology analysis; according to the invention, through multi-source data acquisition, dynamic growth stage division, accurate model prediction, three-dimensional phenotype monitoring and self-correction decision optimization, the accuracy of analysis decision for crop growth monitoring data is improved.

The invention relates to the technical field of computer vision and target detection, in particular to an improved Yolov10-oriented target detection fusion method, which specifically comprises the following steps of: selecting data to construct a data set, and then preprocessing the data in the data set to obtain a preprocessed data set; the method comprises the following steps: preprocessing a data set, enhancing the preprocessed data set, constructing a target identification network model based on a lightweight Yov10n network, improving the Yov10n network, the improved Yov10n network comprising an input end, a backbone network, a neck network and an output end, and introducing four context fusion CFM modules into the neck network, the CFM module comprises a channel adjustment convolution module, a feature splicing module, an attention module, a weighted feature recombination module and an output feature generation module; and inputting the image data in the preprocessed data set into the improved constructed target recognition network model to obtain a final detection result. According to the method, diversified targets with different scales can be better processed, so that the robustness of the model to a complex background is improved.

This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master / copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

The invention relates to the technical field of seed processing analysis, in particular to a big data-based rape seed quality evaluation model, which is characterized in that a data pool is constructed by converging multi-source heterogeneous rape data, and high-quality input is provided for subsequent cross-domain feature association; a cross-domain feature interaction graph is constructed, a graph neural network is used for learning, cross-domain feature interaction is visually presented, and a gene-environment interaction relationship is analyzed; through a four-branch multi-head and cross-modal attention analysis atlas, focusing key features, fusing optimization information and generating a high-quality feature vector, high-order feature nonlinear fusion is realized, and the characterization capability of the model on multi-source heterogeneous data is remarkably improved; an evaluation model is constructed through decoding vectors, and high-yield variety data is extracted, so that efficient screening of rape varieties is facilitated; by deploying the generative adversarial network and transferring the learning adaptive model, the evaluation capability is quickly expanded to a new variety, and breeding intelligence is promoted.

The invention relates to the technical field of biological information, in particular to a stem cell culture information management method and system. The method comprises the following steps: collecting culture process basic data in a stem cell culture process, wherein the culture process basic data comprises cell counting data, culture condition parameter data and pollution condition data; performing growth kinetic analysis on the basic data in the culture process to obtain cell growth characteristic data; establishing a cell growth prediction model based on the cell growth characteristic data, and generating cell growth early warning data; and monitoring the culture process in real time according to the cell growth early warning data, triggering an early warning signal when abnormal fluctuation is detected, and generating a culture abnormality processing scheme. The growth prediction model is established based on the cell growth characteristic data, the culture dynamic state can be monitored in real time, an early warning signal is provided, the detection and response speed of abnormal fluctuation is remarkably improved, and culture failure is avoided.

The present disclosure provides devices, systems, and methods for capturing and analyzing behavioral and physiological data of subjects for treatment, modification, and manipulation discovery. In some embodiments, a method for classifying a drug is provided. The method includes obtaining observational data concerning an animal subject to which the drug is administered, the observational data acquired using an enclosure for the animal subject, the enclosure instrumented with at least one sensing device. The method also includes extracting features by applying the observational data to a machine-learning feature-extraction component. The method further includes predicting a class label of the drug by applying the features to a machine-learning classifier component, the machine-learning classifier component trained to predict the class label of the drug from, at least in part, the features. The method further includes providing an indication of the class label.

Methods for making synthetic gene clusters are described.

The application includes systems and methods for phenotyping. A request is received to identify a target population having a phenotype. Predefined characteristics associated with the phenotype are obtained. Using a retriever model, a set of subjects is identified as potential members of the target population by searching databases. Medical information is obtained by searching a second set of one or more databases and providing corresponding information to an artificial intelligence (AI) component. Natural language instructions are provided to the AI component to provide context to the AI component to determine whether a respective subject in the set of subjects has at least one of the one or more predefined characteristics. A subset of subjects is identified by the AI system to be, or to have a high likelihood of being, a member of the target population.

The invention relates to the field of drug target interaction, and discloses an application of a multi-modal feature fusion model in drug target binding affinity prediction, which comprises the following steps: S1, obtaining an original data set of drug target binding affinity, and taking a binding affinity index in the data set as a label of a training set and a test set; s2, acquiring representation information of other modals by using the drug sequence and target sequence representation provided in the original data set, preprocessing the acquired representation information of drugs and targets in different modals, and processing the representation information into a model acceptable feature vector form; and S3, respectively storing the multi-modal feature vectors of the drug and the target as well as the binding affinity tags in a form of pytorchsensor (. Pt). According to the method, shallow characterization of the drug and protein sequences is learned by applying the pre-training model, and the problem that a drug target binding affinity data set is insufficient is solved.

The invention relates to the technical field of electrical digital data processing, in particular to an anomaly detection and processing method and system based on deep learning. The method comprises the following steps: firstly, performing feature extraction and fusion on a log text sequence, a log timestamp sequence and a running state index sequence set to obtain an initial feature vector sequence; then, constructing a hierarchical graph neural network to perform feature updating, propagation and fusion on the initial feature vector sequence to obtain a multi-level fusion feature vector sequence, and calculating a standardized mode vector sequence in combination with a log text sequence and a running state index sequence set; obtaining a self-adaptive abnormal threshold value according to the standardized mode vector sequence and detecting candidate abnormal logs; and finally, verifying the candidate abnormal logs, determining verified abnormal logs, classifying the verified abnormal logs, generating a processing suggestion text according to a classification result, and carrying out early warning prompt. The false detection rate can be reduced, and the log anomaly detection accuracy is improved.

The invention relates to a data processing method and system for multi-source complex biological information data. According to the method, expression profile data, gene variation data and clinical survival data are collected, and unified standardization processing is carried out on the collected data. Feature alignment is performed on different source data based on sample identifiers, a joint feature expression matrix is constructed, and a context dependency relationship across data types is maintained. On the basis, multi-stage feature screening is carried out through Lasso regression and information gain evaluation in sequence, and an optimal feature subset used for modeling is obtained. And further training a risk scoring model by adopting a Cox proportional risk regression method, and calculating a risk scoring value of the sample by utilizing the constructed continuous scoring function. And finally, dividing the score value into a plurality of risk levels, and generating a survival curve of each level in combination with a Kaplan-Meier estimation method so as to verify the risk layering effect and prediction significance of the model. According to the method, the accuracy of biological information modeling can be improved, and the method has good universality and practical value.

The invention discloses a drug combination risk prediction method and device based on multi-source feature fusion and comparative learning, equipment and a medium, and relates to the technical field of drug combination prediction. The drug combination risk prediction method comprises the following steps: acquiring a drug data set; and obtaining a feature map according to the drug data set. And according to the feature map, carrying out adaptive feature extraction on the molecular map structure to obtain molecular map features of the medicine. And defining molecular map features as structural features. And inputting the molecular graph features into a multi-layer cascaded graph convolutional network, extracting high-order topological features in a drug network, and obtaining relation features. According to the drug data set, similarity features are calculated, and interactive embedding features are extracted; according to the structural features and the similarity features, potential correlation and differences between the features are mined through a comparative learning mechanism, and structural comparative learning features and similarity comparative learning features are obtained; and performing feature fusion and feature alignment on the features to obtain fused features. And predicting the drug combination risk according to the fusion features.