10414 results about "Computational biology" patented technology

The technology described herein relates to systems, methods, and computer storage media, among other things, for providing search query intent specificity. Embodiments may include identifying a search query performed using a search engine and generating a query vector for the search query by aggregating search result embeddings (e.g., item listing vectors) of search results from the search query. Further, in some embodiments, similarities (e.g., cosine similarities) between the query vector and the item listing vectors can be determined. As such, an intent specificity of the search query can be determined. Further, in some embodiments, the intent specificity can be used to train an intent specificity machine learning model for generating intent specificity scores for other search queries. Based on the intent specificity scores determined using the one or more trained intent specificity machine learning models, determinations can be made with respect to precision and recall, etc.

A federated distributed computational system enables secure biological data analysis and genomic medicine with enhanced oncological therapy capabilities. The system implements patient-specific tumor-on-a-chip analysis through microfluidic control systems and cellular heterogeneity preservation, while integrating fluorescence-enhanced diagnostics using CRISPR-LNP targeting and robotic surgical navigation. The architecture coordinates spatiotemporal analysis of gene therapy delivery through molecular imaging and immune response tracking, and implements bridge RNA integration with multi-target synchronization. Treatment selection is optimized through multi-criteria scoring and patient-specific simulation modeling. Each federated node contains a local processing unit for biological data analysis, privacy preservation protocols, and a hierarchical knowledge graph structure. The system implements cross-species genetic analysis, environmental response modeling, and multi-scale tensor-based data integration, enabling research institutions to collaborate on complex, large-scale biological analyses while maintaining strict data privacy controls.

The invention provides a cross-modal retrieval method for semantic and vector fusion in a data space, which belongs to the field of cross-modal information retrieval, and comprises the following steps: firstly, collecting and preprocessing multi-modal data; generating modal embedding and storing by utilizing the pre-training model; a shared semantic space is constructed, cross-modal vector alignment is optimized through comparative learning, and a modal mapping network is designed to enhance the embedding projection effect; storing the aligned embedding by using a Milvus database, and constructing an HNSW index; user text or image query is processed, text query analyzes limiting conditions to generate enhanced embedding, and image query extracts characters through OCR and fuses the characters with image features to generate embedding; in a database, through condition screening and semantic similarity calculation, a Top-K candidate item is retrieved; performing multi-modal correlation sorting on the candidate results and returning the results; according to the method, the shared semantic space is constructed, the alignment effect of different modal embedding is optimized, efficient storage and index management of multi-modal embedding are carried out, and real-time retrieval of large-scale cross-modal data is achieved.

Provided herein are methods, kits, and compositions for determining the spatial location of non-coding RNA, such as siRNA and / or miRNA in a biological sample.

Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

Provided herein are methods of identifying genetic variants in biological samples. In particular, the present disclosure uses spatial transcriptomic templated ligation methods and compositions to identify the presence or absence, and the location of genetic variants in the transcriptome or genome of a biological sample.

The invention relates to a drug-disease relationship prediction method and system based on a dual-channel fusion knowledge graph. The method comprises the following steps: S1, constructing a biomedical fusion knowledge graph; s2, constructing a drug-disease sub-graph based on the biomedicine fusion knowledge graph; s3, constructing a dual-channel adaptive fusion feature module, and embedding a drug-disease sub-graph; s4, performing enhanced splicing on the drug-disease sub-graphs in the dual-channel fusion knowledge graph pre-embedded network, importing an edge-node iterative updating learning mechanism, training a spliced sub-graph relation perception learning network, and obtaining enhanced sub-graph feature embedding; and S5, utilizing the trained enhanced subgraph features to embed, calculate and output the prediction probability of the drug-disease relationship. According to the method, the semantic representation capability of the knowledge graph and the topological modeling advantages of the graph neural network are integrated, and efficient and accurate prediction of the drug-disease relationship is realized through multi-modal feature interaction, sub-graph enhancement and a dynamic sub-graph learning mechanism.

Provided herein are methods, compositions, and kits to spatially detect genetic variants in a target nucleic acid via templated-ligation and reversible terminator nucleotides.

The invention provides a data consanguinity full-link traceability method and system based on multi-source heterogeneous metadata and a pre-training large model. The method comprises the following steps: S1, collecting metadata and preprocessing the data; s2, identifying the data processed in the S1 by using a data consanguinity detection model, and outputting a consanguinity probability matrix between data entities; s3, filtering the blood relationship probability matrix based on a dynamic threshold value to generate a blood relationship map; and S4, rendering the blood relationship graph obtained in the S3 to visualize the data blood relationship. By means of metadata multi-dimensional feature extraction and end-to-end training of a deep learning large model, the problems that a traditional technology is rigid in rule, low in calculation efficiency, insufficient in semantic understanding and the like are solved, and high-precision and self-adaptive data blood relationship modeling is achieved.

The invention relates to the technical field of data decision, in particular to an analysis decision method for crop growth monitoring data. The method comprises the following steps: collecting crop phenotypic characteristic data through a multi-source sensing array; dynamically dividing crop growth response stages according to phenotypic characteristics; constructing a growth situation prediction model based on the crop growth response stage; inputting the phenotypic characteristic data into a growth situation prediction model, simulating a crop growth process through a digital twin engine, and generating growth situation evolution data; extracting physiological anomaly characteristics of the growth situation evolution data, and generating stress response signals; obtaining a canopy three-dimensional phenotype map based on the stress response signal; positioning vascular bundle nodes of the canopy three-dimensional phenotype map through morphological topology analysis; according to the invention, through multi-source data acquisition, dynamic growth stage division, accurate model prediction, three-dimensional phenotype monitoring and self-correction decision optimization, the accuracy of analysis decision for crop growth monitoring data is improved.

The invention relates to the technical field of computer vision and target detection, in particular to an improved Yolov10-oriented target detection fusion method, which specifically comprises the following steps of: selecting data to construct a data set, and then preprocessing the data in the data set to obtain a preprocessed data set; the method comprises the following steps: preprocessing a data set, enhancing the preprocessed data set, constructing a target identification network model based on a lightweight Yov10n network, improving the Yov10n network, the improved Yov10n network comprising an input end, a backbone network, a neck network and an output end, and introducing four context fusion CFM modules into the neck network, the CFM module comprises a channel adjustment convolution module, a feature splicing module, an attention module, a weighted feature recombination module and an output feature generation module; and inputting the image data in the preprocessed data set into the improved constructed target recognition network model to obtain a final detection result. According to the method, diversified targets with different scales can be better processed, so that the robustness of the model to a complex background is improved.

This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master / copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

The invention relates to the technical field of seed processing analysis, in particular to a big data-based rape seed quality evaluation model, which is characterized in that a data pool is constructed by converging multi-source heterogeneous rape data, and high-quality input is provided for subsequent cross-domain feature association; a cross-domain feature interaction graph is constructed, a graph neural network is used for learning, cross-domain feature interaction is visually presented, and a gene-environment interaction relationship is analyzed; through a four-branch multi-head and cross-modal attention analysis atlas, focusing key features, fusing optimization information and generating a high-quality feature vector, high-order feature nonlinear fusion is realized, and the characterization capability of the model on multi-source heterogeneous data is remarkably improved; an evaluation model is constructed through decoding vectors, and high-yield variety data is extracted, so that efficient screening of rape varieties is facilitated; by deploying the generative adversarial network and transferring the learning adaptive model, the evaluation capability is quickly expanded to a new variety, and breeding intelligence is promoted.

The invention relates to the technical field of biological information, in particular to a stem cell culture information management method and system. The method comprises the following steps: collecting culture process basic data in a stem cell culture process, wherein the culture process basic data comprises cell counting data, culture condition parameter data and pollution condition data; performing growth kinetic analysis on the basic data in the culture process to obtain cell growth characteristic data; establishing a cell growth prediction model based on the cell growth characteristic data, and generating cell growth early warning data; and monitoring the culture process in real time according to the cell growth early warning data, triggering an early warning signal when abnormal fluctuation is detected, and generating a culture abnormality processing scheme. The growth prediction model is established based on the cell growth characteristic data, the culture dynamic state can be monitored in real time, an early warning signal is provided, the detection and response speed of abnormal fluctuation is remarkably improved, and culture failure is avoided.

The invention relates to a data processing method and system for multi-source complex biological information data. According to the method, expression profile data, gene variation data and clinical survival data are collected, and unified standardization processing is carried out on the collected data. Feature alignment is performed on different source data based on sample identifiers, a joint feature expression matrix is constructed, and a context dependency relationship across data types is maintained. On the basis, multi-stage feature screening is carried out through Lasso regression and information gain evaluation in sequence, and an optimal feature subset used for modeling is obtained. And further training a risk scoring model by adopting a Cox proportional risk regression method, and calculating a risk scoring value of the sample by utilizing the constructed continuous scoring function. And finally, dividing the score value into a plurality of risk levels, and generating a survival curve of each level in combination with a Kaplan-Meier estimation method so as to verify the risk layering effect and prediction significance of the model. According to the method, the accuracy of biological information modeling can be improved, and the method has good universality and practical value.

The invention discloses a drug combination risk prediction method and device based on multi-source feature fusion and comparative learning, equipment and a medium, and relates to the technical field of drug combination prediction. The drug combination risk prediction method comprises the following steps: acquiring a drug data set; and obtaining a feature map according to the drug data set. And according to the feature map, carrying out adaptive feature extraction on the molecular map structure to obtain molecular map features of the medicine. And defining molecular map features as structural features. And inputting the molecular graph features into a multi-layer cascaded graph convolutional network, extracting high-order topological features in a drug network, and obtaining relation features. According to the drug data set, similarity features are calculated, and interactive embedding features are extracted; according to the structural features and the similarity features, potential correlation and differences between the features are mined through a comparative learning mechanism, and structural comparative learning features and similarity comparative learning features are obtained; and performing feature fusion and feature alignment on the features to obtain fused features. And predicting the drug combination risk according to the fusion features.

The invention discloses a voiceprint recognition, identity confirmation and dialogue implementation method applied to sentiment analysis, which can well realize voiceprint recognition and identity confirmation, and can realize mute detection, recording control and recording end judgment and release. Comprising voiceprint recognition and identity confirmation: firstly, determining whether the source of recorded audio is the sound of a specific person by adopting a voiceprint recognition technology; the voiceprint recognition generally performs identity verification by extracting audio features and comparing the extracted audio features with a pre-stored template. The mathematical formula is as follows: assuming that the feature of the input audio is X = {x1, x2,..., xn} and the voiceprint template is T = {t1, t2,..., tm}, the recognition process can be represented as # imgabs0 #, and the # imgabs1 # represents the recognized user tag xj-ti2 represents the Euclidean distance between feature vectors. According to the method, sound cloning and emotion adjustment are realized through deep learning models (GANs and VAEs). In the whole process, through training and optimization of the deep neural network, high-quality emotional voice is generated, and more natural and personalized voice interaction experience is provided.

A database structure obtained by means of information retrieval, and a reasoning system, which structure and system specifically relate to a gut microbe knowledge graph system, comprising: a gut microbe knowledge graph consisting of a gut microbe knowledge base, a gut microbe and small-molecule drug therapy association knowledge base, and a clinical medicine database; and a multimodal uncertainty reasoning system, using the gut microbe knowledge graph. The gut microbe knowledge graph system predicts potential diseases, drugs, genes, etc., which are associated with gut microbes.

The invention relates to the technical field of data processing and analysis, and discloses a space-time co-occurrence analysis method and system for multi-source data fusion, and the method comprises the steps: firstly obtaining the multi-source heterogeneous data of a target area, carrying out the space-time calibration, constructing a space-time reference coordinate system, carrying out the space-time alignment, and generating a space-time weight matrix and a correlation feature vector set; and obtaining a space-time correlation characteristic spectrum through space-time sliding window segmentation and characteristic fusion, and training a co-occurrence mode mining model to extract a space-time co-occurrence mode characteristic set. And constructing an anomaly detection model and verifying to obtain an anomaly co-occurrence mode set, and constructing a parameter optimization model to dynamically adjust data acquisition parameters. And finally, updating the coordinate system according to the optimal parameters and the real-time data and generating an analysis report. According to the method and the system, multi-source heterogeneous data can be effectively processed, a space-time co-occurrence mode can be mined, abnormity can be accurately detected, data acquisition parameters can be optimized, and powerful support can be provided for decisions in related fields.

An online system may provide an instruction prompt to a machine-learned language model. The instruction prompt may include an instruction to generate an evaluation label of a training sample of a classification model and a textual format related to how data is arranged. The evaluation label may be used in a supervised training of the classification model. The online system may provide a batch of evaluation request prompts to the machine-learned language model. Each evaluation request prompt includes data that is at least partially arranged in the textual format described in the instruction prompt. The online system may receive a plurality of responses from the machine-learned language model. Each response includes the evaluation label corresponding to each evaluation request prompt. The online system may store at least evaluation labels and the data in the evaluation request prompts as training samples for the supervised training of the classification model.

The invention discloses a method for comprehensively identifying PFAS in an environment by combining targeted analysis, suspicious screening and non-targeted identification. The method comprises the following steps: S1, carrying out liquid chromatography-high resolution mass spectrometry fullscan / DDA / DIA analysis on an environmental sample; s2, carrying out liquid chromatography-high resolution mass spectrometry analysis on the plurality of PFAS standard substances; s3, according to a public chemical database and literature, collecting names and molecular formulas of a plurality of PFASs, calculating an accurate mass number, and jointly establishing a suspicious screening database in combination with an open-source MS2 spectrogram library; s4, establishing a non-targeted identification work flow by combining the mass number characteristics of the PFAS, the characteristic MS2 fragments, the characteristic neutral loss and the homolog characteristics; and S5, integrating the targeted analysis compound, the candidate compound subjected to suspicious screening and the candidate compound subjected to non-targeted identification, and comprehensively identifying the PFAS in the environmental sample. According to the method disclosed by the invention, the known and unknown perfluoroalkyl / polyfluoroalkyl compounds are fully identified through three complementary analysis technologies.

Systems and methods for leveraging semantic information for a multi-domain visual agent. Semantic information can be leveraged to obtain a multi-domain visual agent. To train the multi-domain visual agent, questions can be sampled from question templates for domain-specific label spaces to obtain a unified label space. The domain-specific labels from the domain-specific label spaces can be mapped into natural language descriptions (NLD) to obtain mapped NLD. The mapped NLD can be converted into prompts by combining the questions sampled from the unified label space and the annotations. The semantic information can be learned by iteratively generating outputs from tokens extracted from the prompts using a large-language model (LLM). The multi-domain visual agent (MDVA) can be trained using the semantic information.

The invention discloses a microbial fermentation strain breeding control system based on a neural network model, and relates to the technical field of digital fermentation, and the system comprises a thallus data acquisition module, a biological feature recognition module, a prediction classification module, a breeding decision module, an optimization training module, an early warning monitoring module and a sorting regulation module. The bacterial data acquisition module preprocesses bacterial data; the biological feature recognition module constructs a bacterial feature library; the prediction classification module predicts the adaptability of bacterial strains and classifies the bacterial strains; the selection decision module selects the bacterial strains and generates culture parameters; the sorting regulation and control module generates a three-dimensional scatter diagram and a hereditary character report. According to the method, the precision and efficiency of breeding of the microbial fermentation strain are remarkably improved, intelligence and automation of the breeding process are achieved, the labor cost is reduced, the stability and controllability of the fermentation process are enhanced, and powerful technical support is provided for innovative development of the microbial fermentation industry.

The invention discloses a fry culture dynamic monitoring and feeding optimization method based on deep learning. The method comprises the following steps: S1, installing a water quality sensor and a camera to collect water quality data and fry image data; s2, performing feature extraction on the fry image data by using an improved convolutional neural network; s3, analyzing a growth trend and an activity mode of the fry by using a long-short-term memory network to obtain a comprehensive score; s4, obtaining a feeding strategy based on a multi-target adaptive PPO algorithm, and forming a personalized feeding plan; s5, performing detection and early warning on abnormal data through an anomaly detection algorithm, and adjusting a breeding environment; and S6, continuously optimizing the fry culture dynamic monitoring model. According to the method, an efficient and scientific optimization scheme can be provided in dynamic monitoring and feeding of fry culture, and remarkable technical value and economic benefits are brought to practical application.

A Data Storage Device (DSD) includes a first memory storing reference files used to derive vector embeddings in a vector database. A query vector embedding is received from a host and one or more vector embeddings similar to the query vector embedding are identified in the vector database. One or more reference files from which the one or more vector embeddings were derived are identified and stored in a second memory for faster access. In another aspect, a query vector embedding is received by a host that identifies one or more vector embeddings that are similar to the query vector embedding and retrieves the one or more vector embeddings from a DSD to provide to an Artificial Intelligence (AI) model. One or more reference files are identified from which the one or more vector embeddings were derived and are prefetched from the DSD for storage in a host memory.

The invention relates to the field of microbial communities, and discloses a bioinformatics-based microbial community dynamic monitoring method, which comprises the following steps: acquiring high-frequency acquisition data based on a trace sample, constructing a microbial data stream for time sequence analysis, and carrying out rapid metagenome marker amplification on each sampling unit in the data stream, obtaining a preliminary feature matrix; based on the co-occurrence frequency of the microbial functional genes in the preliminary feature matrix, constructing a multi-dimensional feature mapping graph; performing real-time mode recognition on the flora abundance change trend based on the dynamic fluctuation region; aiming at the key dynamic signal segment, adopting a distributed clustering method based on variation information entropy regulation and control to reconstruct the evolution trajectory of the flora, and generating a flora time sequence behavior vector set; and based on the flora time sequence behavior vector set, performing dynamic alignment with a pre-constructed reference model by using a multi-scale trend matching algorithm. The method has the advantages of high timeliness and automatic processing capability.

The invention discloses a drug target interaction prediction method based on a protein sequence. The method comprises the following steps: constructing a drug target database; constructing a target feature extractor based on a pre-trained protein language model; constructing a drug feature extractor based on a pre-trained molecular model; constructing a feature learning method by adopting a self-attention mechanism, constructing a drug target interaction learning method by adopting a cross attention mechanism, constructing a predictor in combination with a linear layer, and constructing a prediction drug target interaction model; training and optimizing parameters of the drug target interaction prediction model to obtain an optimized drug target prediction model; inputting a drug target into the optimized prediction model, outputting a prediction result, and finally marking potential active sites and important amino acid residues of the drug and the target through attention score visualization. According to the method, the precision of predicting the interaction between the drug and the target spot based on the protein sequence is improved, and the interpretability of the deep learning model is realized.

Described herein is an Autonomous Conversational AI system, which does not require any human configuration or annotation, and is used to have multi-turn dialogs with a user. A typical Conversational AI system consists of three main models: Natural Language Understanding (NLU), Dialog Manager (DM) and Natural Language Generation (NLG), which requires human provided data and configuration. The system proposed herein leverages novel Conversational AI methods which automatically generates conversational AI configuration from any historical conversation logs. The automatically generated configuration contains Auto-Topics, Auto-Subtopics, Auto-Intents, Auto-Responses and Auto-Flows which are used to automatically train NLU, DM and NLG models. Once these models are trained for given conversation logs, the system can be used to have dialog with any user.

The invention discloses an intelligent breeding method for commercial crops based on big data analysis, and relates to the technical field of agricultural breeding, the method comprises the following specific steps: seed multi-modal data acquisition and processing: acquiring physical characteristic data of seeds, acquiring physiological indexes and genome information data through biochemical experiments and gene sequencing, and determining the seed multi-modal data according to the physiological indexes and the genome information data; carrying out pretreatment on the raw materials; according to the method, after multi-modal data are integrated and preprocessed, a seed vigor accurate evaluation model is constructed by using deep learning and data fusion technologies, the seed vigor level can be measured more accurately, and meanwhile, the electric signal change of the early growth stage of crops is monitored in real time by using high-precision plant electric signal acquisition equipment, so that the accuracy of the seed vigor evaluation is improved. And a correlation model of the electric signal characteristics and multiple traits of crops is established, and fusion analysis is performed on seed vigor evaluation data and plant electric signal data, so that the breeding efficiency is greatly improved, and powerful support is provided for cultivation of high-quality varieties.