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546 results about "Genetic analysis" patented technology
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Genetic analysis is the overall process of studying and researching in fields of science that involve genetics and molecular biology. There are a number of applications that are developed from this research, and these are also considered parts of the process. The base system of analysis revolves around general genetics. Basic studies include identification of genes and inherited disorders. This research has been conducted for centuries on both a large-scale physical observation basis and on a more microscopic scale. Genetic analysis can be used generally to describe methods both used in and resulting from the sciences of genetics and molecular biology, or to applications resulting from this research.
Multiplexed analysis of clinical specimens apparatus and method
InactiveUS6524793B1Simple methodSure easyMicrobiological testing/measurementEnzymologyReal time analysisDNA fragmentation
A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset, exposing the beadset to a clinical sample, and analyzing the combined sample / beadset by flow cytometry. Flow cytometric measurements are used to classify, in real-time, beads within an exposed beadset and textual explanations, based on the accumulated data obtained during real-time analysis, are generated for the user. The inventive technology enables the simultaneous, and automated, detection and interpretation of multiple biomolecules or DNA sequences in real-time while also reducing the cost of performing diagnostic and genetic assays.
Owner:LUMINEX
Microfabricated integrated DNA analysis system
ActiveUS20050287572A1Improve automationBig spaceBioreactor/fermenter combinationsElectrolysis componentsMicroreactorMicrosphere
Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments. The microfabricated structure may be used in a process for performing sequencing and other genetic analysis of DNA or RNA.
Owner:RGT UNIV OF CALIFORNIA
Use of highly parallel SNP genotyping for fetal diagnosis
InactiveUS20080070792A1Eliminate riskAnalysis time-consume and proneMicrobiological testing/measurementLibrary screeningDiseaseBiology
The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.
Owner:VERINATA HEALTH INC
Multiplexed analysis of clinical specimens apparatus and method
InactiveUS6939720B2Sure easyMicrobiological testing/measurementEnzymologyReal time analysisDNA fragmentation
Owner:LUMINEX
Methods for identifying biological samples
InactiveUS20060073506A1Efficient amplificationSugar derivativesMicrobiological testing/measurementNucleic acid sequencingCross hybridization
The present invention provides methods for marking nucleic acid samples with detectable markers by adding different combinations of marker molecules to each sample. Each sample may be marked with a different combination of two or more marker molecules each carrying a different tag nucleic acid sequences. The tag nucleic acid sequences may be random sequences that are not naturally occurring in the nucleic acid sample and do not cross hybridize to sequences naturally occurring in the nucleic acid sample. Methods of detecting the combination of tag sequences present in a sample, in parallel with methods of genetic analysis of the sample are disclosed. Kits containing marker molecules suitable for generating barcoded samples by mixing different combinations of marker molecules into each sample are also disclosed.
Owner:AFFYMETRIX INC
Evaluating Genetic Disorders
ActiveUS20070259351A1Microbiological testing/measurementProteomicsGeneticsArray-Based Comparative Genomic Hybridization
The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a subject or subject group.
Owner:POPULATION BIO INC
Miniaturized genetic analysis systems and methods
InactiveUS20050202504A1Bioreactor/fermenter combinationsShaking/oscillating/vibrating mixersBioinformaticsComputational biology
Owner:AFFYMETRIX INC
Methods and uses for molecular tags
ActiveUS20160026758A1Overcome limitationsImprove accuracyMicrobiological testing/measurementLibrary member identificationGenetic analysisComputational biology
Methods and uses for molecular tags are disclosed. Molecular tags may be attached to nucleic acid molecules. The attachment of the nucleic acid molecules prior to PCR amplification and sequencing improves the accuracy of genetic analysis and detection of genetic variations and diversity. Molecular tags may also be used for detection of drug-resistant variants. Methods for using molecular tags for determining and correcting PCR errors and / or sequencing error are also disclosed.
Owner:THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
ActiveUS20100285975A1Efficient routingEfficient single-molecule amplificationTransportation and packagingLibrary screeningEmulsionMicroparticle
Provided are microfluidic designs and methods for rapid generation of monodisperse nanoliter volume droplets of reagent / target (e.g., molecule or cell) mix in emulsion oil. The designs and methods enable high-throughput encapsulation of a single target (e.g., DNA / RNA molecules or cells) in controlled size droplets of reagent mix. According to various embodiments, a microfabricated, 3-valve pump is used to precisely meter the volume of reagent / target mix in each droplet and also to effectively route microparticles such as beads and cells into the device, which are encapsulated within droplets at the intersection of the reagent channel and an oil channel. The pulsatile flow profile of the microfabricated pumps provides active control over droplet generation, thereby enabling droplet formation with oils that are compatible with biological reactions but are otherwise difficult to form emulsions with.
Owner:RGT UNIV OF CALIFORNIA
Gel microdrops in genetic analysis
InactiveUS6586176B1Bioreactor/fermenter combinationsBiological substance pretreatmentsSingle entityVirus
The invention provides methods of nucleic acid analysis. Such methods entail forming a population of gel microdrops encapsulating a population of biological entities, each entity comprising a nucleic acid, whereby at least some microdrops in the population each encapsulate a single entity. The population of gel microdrops is then contacted with a probe under conditions whereby the probe specifically hybridizes to at least one complementary sequence in the nucleic acid in at least one gel microdrop. At least one gel microdrop is then analyzed or detected. The biological entities can be cells, viruses, nuclei and chromosomes.
Owner:CELLAY
Microfabricated integrated DNA analysis system
ActiveUS7799553B2Improve automationBig spaceBioreactor/fermenter combinationsElectrolysis componentsMicroreactorMicrosphere
Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments. The microfabricated structure may be used in a process for performing sequencing and other genetic analysis of DNA or RNA.
Owner:RGT UNIV OF CALIFORNIA
Genetic analysis by sequence-specific sorting
Owner:AGENCY FOR SCI TECH & RES
Genetic analysis by sequence-specific sorting
ActiveUS20060177832A1Microbiological testing/measurementFermentationPolynucleotideHybridization Array
The invention provides methods for sorting polynucleotides from a population based on predetermined sequence characteristics. In one aspect, the method of the invention is carried out by extending a primer annealed polynucleotides having predetermined sequence characteristics to incorporate a predetermined terminator having a capture moiety, capturing polynucleotides having extended primers by a capture agent that specifically binds to the capture moiety, and melting the captured polynucleotides from the extended primers to form a subpopulation of polynucleotides having the predetermined sequence characteristics. In another aspect, the method of the invention is carried out on a population of tagged polynucleotides so that after a subpopulation is selected, the members of the subpopulation may be simultaneously analyzed using the unique tags on the polynucleotides to convey analytical information to a hybridization array for a readout.
Owner:AGENCY FOR SCI TECH & RES
Fetal aneuploidy detection by sequencing
InactiveUS20100291572A1Eliminate riskAnalysis time-consume and proneMicrobiological testing/measurementFetal aneuploidyBiology
Owner:ARTEMIS HEALTH INC
Methods for genetic analysis of DNA using biased amplification of polymorphic sites
InactiveUS6475736B1Efficient amplificationEasily and robustly analyzedSugar derivativesMicrobiological testing/measurementHaplotypeDNA
Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
Owner:AGENA BIOSCI
Enrichment of circulating fetal DNA
InactiveUS20070243549A1High accuracy of resultsMicrobiological testing/measurementImmunoglobulins against animals/humansNon invasiveMolecular diagnostics
A non-invasive screening or diagnostic method for determining the likelihood of a fetus with a genetic abnormality or a potential pregnancy complication, which utilizes a liquid blood sample from a pregnant woman. Antibodies specific to a section of histone 3.1 which is exposed to a far greater extent in chromatin of fetal origin than in chromatin of maternal origin are used to sequester and isolate such fetal nucleosomes including the associated fetal DNA. Following isolation / enrichment of such fetal DNA, genetic analysis is carried out using known molecular diagnostics.
Owner:BAYLOR COLLEGE OF MEDICINE
Methods for targeted genomic analysis
ActiveUS20140274731A1Sugar derivativesMicrobiological testing/measurementSpecific detectionGene expression profiling
The invention provides a method for genetic analysis in individuals that reveals both the genetic sequences and chromosomal copy number of targeted and specific genomic loci in a single assay. The present invention further provide methods for the sensitive and specific detection of target gene sequences and gene expression profiles.
Owner:RESOLUTION BIOSCI
Genetic analysis and authentication
InactiveUS7157228B2Reduce morbidityBioreactor/fermenter combinationsBiological substance pretreatmentsBiological bodyGenetic Screening (procedure)
This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
Owner:BIOARRAY SOLUTIONS
Gel microdroplets in genetic analysis
InactiveUS20030207260A1Bioreactor/fermenter combinationsBiological substance pretreatmentsVirusSingle entity
Owner:ONE CELL SYST
Methods for genetic analysis
Several methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to compute a score for the individual, and comparing the score to at least one threshold value.
Owner:GENETIC TECHNOLOGIES LIMTIED
Methods of genetic analysis of mouse
InactiveUS7250289B2Bioreactor/fermenter combinationsBiological substance pretreatmentsNucleic acid sequencingNucleic acid sequence
The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of mouse genes. The invention provides the sequences in such a way as to make them available for a variety of analyses. In one embodiment the nucleic acid sequences provided are present as an array of probes that may be used to measure gene expression of at least 30,000 mouse genes. As such, the invention relates to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics.
Owner:AFFYMETRIX INC
Methods of genetic analysis of mouse
InactiveUS20050026164A1Monitor gene expression levelBioreactor/fermenter combinationsBiological substance pretreatmentsChemical biologyNucleic acid sequencing
Owner:AFFYMETRIX INC
Use of uracil-DNA glycosylase in genetic analysis
InactiveUS6090553AImprove hybridization efficiencyIntensity of signal may decreaseHydrolasesMicrobiological testing/measurementGenetic analysisPolymerase chain reaction
The present invention relates to a process for detecting the presence of at least one specific nucleic acid sequence in a sample containing a nucleic acid or a mixture of nucleic acids by amplifying the nucleic acid using polymerase chain reaction, cleaving the amplified products with uracil DNA glycosylase to obtain short DNA segments and detecting the DNA fragments by using reverse blot hybridization.
Owner:AFFYMETRIX INC
Methods for quantitative genetic analysis of cell free DNA
InactiveUS20160053301A1Microbiological testing/measurementLibrary screeningCell freeSpecific detection
The invention provides a method for genetic analysis in individuals that reveals both the genetic sequences and chromosomal copy number of targeted and specific genomic loci in a single assay. The present invention further provides methods for the sensitive and specific detection of target gene sequences and gene expression profiles.
Owner:RESOLUTION BIOSCI
Miniaturized genetic analysis systems and methods
InactiveUS20060246490A1Bioreactor/fermenter combinationsBiological substance pretreatmentsMiniaturizationBioinformatics
Owner:AFFYMETRIX INC
Genetic analysis by sequence-specific sorting
ActiveUS7217522B2Microbiological testing/measurementNucleic acid reductionPolynucleotideHybridization Array
The invention provides methods for sorting polynucleotides from a population based on predetermined sequence characteristics. In one aspect, the method of the invention is carried out by extending a primer annealed polynucleotides having predetermined sequence characteristics to incorporate a predetermined terminator having a capture moiety, capturing polynucleotides having extended primers by a capture agent that specifically binds to the capture moiety, and melting the captured polynucleotides from the extended primers to form a subpopulation of polynucleotides having the predetermined sequence characteristics. In another aspect, the method of the invention is carried out on a population of tagged polynucleotides so that after a subpopulation is selected, the members of the subpopulation may be simultaneously analyzed using the unique tags on the polynucleotides to convey analytical information to a hybridization array for a readout.
Owner:AGENCY FOR SCI TECH & RES
Assay systems for genetic analysis
InactiveUS20130040375A1Improve throughputBioreactor/fermenter combinationsBiological substance pretreatmentsAssayPolymorphism Detection
The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
Owner:TANDEM DIAGNOSTICS
Human genomic polymorphisms
InactiveUS20060188875A1Sugar derivativesMicrobiological testing/measurementHuman DNA sequencingInformative snps
The invention provides nucleic acid segments of the human genome including polymorphic sites, SNP haplotype blocks, SNP haplotype patterns for each block and informative SNPs for each pattern. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as association studies and other genetic analyses.
Owner:PERLEGEN SCIENCES INC
Use of highly parallel SNP genotyping for fetal diagnosis
InactiveUS20090291443A1Eliminate riskAnalysis time-consume and proneMicrobiological testing/measurementBiologyGenetic analysis
The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.
Owner:STOUGHTON ROLAND +2
Multiplexed analysis of clinical specimens apparatus and method
InactiveUS20050118574A1Sure easyMicrobiological testing/measurementEnzymologyReal time analysisAssay
Owner:LUMINEX
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