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9454results about "Shaking/oscillating/vibrating mixers" patented technology
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Powered surgical tool with control module that contains a sensor for remotely monitoring the tool power generating unit
ActiveUS7638958B2Shaking/oscillating/vibrating mixersTransportation and packagingEngineeringControl circuit
A powered surgical tool with a housing that contains a power generating unit such as a motor. A control module is disposed in a shell that is mounted in the housing. The control module contains a control circuit for regulating the actuation of the power generating unit. The power generating unit emits a signal representative of the operating state of the unit that is transmitted through the structural material forming the shell. Also internal to the control module shell is a sensor that monitors the signal emitted by the power generating unit. This signal output by the sensor is applied to the control circuit. The control circuit, based on the sensor signal regulates actuation of the power generating unit. Wherein the power generating unit is a motor, the signal emitted is the magnetic field that varies with rotor position. The sensor monitors the strength of this field.
Owner:STRYKER CORP
Vertebroplasty injection device
InactiveUS7008433B2Small sizeIncrease pressurePowder deliveryShaking/oscillating/vibrating mixersInjectable biomaterialBone cement
Owner:DEPUY ACROMED INC
Methods for producing droplets for use in capsule-based electrophoretic displays
Methods are provided for forming a dispersion of substantially uniform droplets. An internal phase that includes a plurality of particles suspended in a first fluid is provided and an external phase including a second fluid is provided. The internal phase is vibrated and the internal phase is applied to the external phase. Either the internal phase or a combination of the internal and external phases form a series of droplets or complex droplets of substantially uniform size.
Owner:E INK CORPORATION
Apparatus for manipulating droplets by electrowetting-based techniques
InactiveUS6911132B2Improve controllabilityImprove accuracyBurnersElectrostatic separatorsElectricityControl manner
An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An additional surface can be provided parallel with the first surface for the purpose of containing the droplets to be manipulated. Droplets are manipulated by performing electrowetting-based techniques in which electrodes contained on or embedded in the first surface are sequentially energized and de-energized in a controlled manner. The apparatus enables a number of droplet manipulation processes, including merging and mixing two droplets together, splitting a droplet into two or more droplets, sampling a continuous liquid flow by forming from the flow individually controllable droplets, and iterative binary or digital mixing of droplets to obtain a desired mixing ratio.
Owner:DUKE UNIV
Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
InactiveUS6948843B2Improve reaction speedAccelerating molecular interactionSequential/parallel process reactionsShaking/oscillating/vibrating mixersSound sourcesAcoustic energy
Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.
Owner:COVARIS INC
Integrated microfluidic assay devices and methods
InactiveUS20090325276A1Low costDeep insightBioreactor/fermenter combinationsBiological substance pretreatmentsAntigenPoint of care
Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.
Owner:PERKINELMER HEALTH SCIENCES INC
Three-dimensional microfluidics incorporating passive fluid control structures
InactiveUS20040109793A1Simple and effective and versatile controlShaking/oscillating/vibrating mixersHeating or cooling apparatusFluid controlMicrofluidics
A three-dimensional microfluidic device (100) formed from a plurality of substantially planar layers (101, 102, 103) sealed together is disclosed
Owner:BIOMICRO SYST
Integrated nucleic acid assays
ActiveUS20090148933A1Reduce pervasive dangerEasy to useBioreactor/fermenter combinationsHeating or cooling apparatusCancer cellAssay
Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
Owner:PERKINELMER HEALTH SCIENCES INC
Compositions and methods for liquid metering in microchannels
InactiveUS20030070677A1Material nanotechnologyShaking/oscillating/vibrating mixersElectrophoresisComputer module
The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. Microdroplets are metered into defined volumes and are subsequently incorporated into a variety of biological assays. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
Owner:RGT UNIV OF MICHIGAN
Chemical analysis apparatus
InactiveUS20060039823A1Improve accuracyHigh mixing precisionAnalysis using chemical indicatorsShaking/oscillating/vibrating mixersCompound (substance)Engineering
A chemical analysis apparatus is equipped with analysis sections having openings, means for supplying samples or reagents from the openings, means for combining and mixing samples with reagents to obtain droplets as liquids to be measured, and means for measuring the physical properties of the liquids to be measured during reaction or after completion of reaction. Furthermore, plate members are provided facing each other in analysis sections and a plurality of electrodes are provided on the plate member faces that face each other. Voltage is applied from the plurality of electrodes to the droplets of the samples and the reagents.
Owner:HITACHI HIGH-TECH CORP
Methods for manipulating droplets by electrowetting-based techniques
InactiveUS20060054503A1Improve controllabilityImprove accuracySludge treatmentShaking/oscillating/vibrating mixersElectricityEngineering
Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.
Owner:DUKE UNIV
Methods and devices for microfluidic point-of-care immunoassays
ActiveUS20090181411A1Endpoint detectionReduce incubation timeBioreactor/fermenter combinationsBiological substance pretreatmentsPoint of careSystems design
Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
Owner:PERKINELMER HEALTH SCIENCES INC
Apparatus and methods for mixing two components
ActiveUS7018089B2Solve the lack of spaceShaking/oscillating/vibrating mixersInfusion syringesEngineeringExtrusion
The apparatus for production of mixtures from two components has a container for each and devices to combine the components in the mixing space and for extrusion of the mixture. The powdered component (4) is situated in the lower part of the inner space (21), which is sealed by a bottom (10). This carries a nozzle (2) with closure membrane (3). The inner space (21) is closed on the top by the lower wall (6) and the sliding seal (8). The liquid component (9) is situated in the inner space (18) of the inner hollow cylinder (5). This is closed on the top by the upper wall (11). The lower and upper wall (6) and (11) each have an opening with sealing lips (7) and (12) that are closed by parts of the mixing rod (15). A torus (20), a section with smaller diameter (19), a mixing disk (22), as well as a mandrel (24), are present on the lower part of the mixing rod (15).
Owner:KYPHON
Droplet-based washing
ActiveUS20070241068A1Reduces and eliminates build-upImprove efficiencyHeating or cooling apparatusShaking/oscillating/vibrating mixersLiquid dropChemistry
The present invention relates to droplet-based washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets comprising: (i) a droplet in contact with the surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the surface.
Owner:ADVANCED LIQUID LOGIC +1
Powered surgical tool with control module that contains a sensor for remotely monitoring the tool power generating unit
A powered surgical tool with a housing that contains a power generating unit such as a motor. A control module is disposed in a shell that is mounted in the housing. The control module contains a control circuit for regulating the actuation of the power generating unit. The power generating unit emits a signal representative of the operating state of the unit that is transmitted through the structural material forming the shell. Also internal to the control module shell is a sensor that monitors the signal emitted by the power generating unit. This signal output by the sensor is applied to the control circuit. The control circuit, based on the sensor signal regulates actuation of the power generating unit. Wherein the power generating unit is a motor, the signal emitted is the magnetic field that varies with rotor position. The sensor monitors the strength of this field.
Owner:STRYKER CORP
Miniaturized genetic analysis systems and methods
InactiveUS20050202504A1Bioreactor/fermenter combinationsShaking/oscillating/vibrating mixersBioinformaticsComputational biology
Owner:AFFYMETRIX INC
Microfluidic Chemical Reaction Circuits
InactiveUS20080281090A1Shaking/oscillating/vibrating mixersTransportation and packagingChemical reactionCompound (substance)
Owner:CALIFORNIA INST OF TECH +3
Vertebroplasty injection device and bone cement therefor
InactiveUS20020156483A1Small sizeIncrease pressurePowder deliveryShaking/oscillating/vibrating mixersInjectable biomaterialVertebroplasty procedure
This invention relates to a mixing and delivery device suitable for delivering injectable biomaterials, and to preferred bone cement formulations.
Owner:DEPUY ACROMED INC
Methods and devices for the preparation, storage and administration of calcium phosphate cements
InactiveUS6149655AStable reductionPromote resultsLiquid surface applicatorsShaking/oscillating/vibrating mixersCalcium biphosphatePhosphoric acid
A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.
Owner:NORIAN CORP
Fluid control structures in microfluidic devices
ActiveUS7445926B2Bioreactor/fermenter combinationsBiological substance pretreatmentsElastomerFluid control
Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
Owner:RGT UNIV OF CALIFORNIA
Multi-Channel Optical Measurement Instrument
ActiveUS20090021728A1Save a lot of costMinimize opportunityShaking/oscillating/vibrating mixersHeating or cooling apparatusAmount of substanceOptical measurements
A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.
Owner:GEN PROBE INC
Apparatus and methods for conducting assays and high throughput screening
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.
Owner:CALIFORNIA INST OF TECH
Microfluidic Synthesis of Organic Nanoparticles
ActiveUS20100022680A1Minimum of laborMinimum of timeCosmetic preparationsMaterial nanotechnologyNanoparticleParticle composition
The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.
Owner:THE BRIGHAM & WOMEN S HOSPITAL INC +1
Apparatus and method for mixing and transferring medications
ActiveUS20070088252A1Accurately and rapidly mixingKeep sterileShaking/oscillating/vibrating mixersMedical devicesVialMedicine
An apparatus and method for transferring a chosen quantity of medication from a vial to an intravenous infuser container under sterile conditions is described. The present invention further facilitates dissolving solid medications contained in the vial or diluting concentrated medications contained in the vial, and transferring the resulting solutions to the infuser container.
Owner:PHARMA MANAGEMENT AGENCY
Methods and apparatus for pathogen detection and analysis
Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of dense arrays of a variety of fluid control structures, such as structures for isolating, routing, merging, splitting, and storing volumes of fluid. The fluid control structures can be used to implement a pathogen detection and analysis system including integrated immunoaffinity capture and analysis, such as polymerase chain reaction (PCR) and capillary electrophoresis (CE) analysis. An analyte solution can be input into the device and pumped through a series of immunoaffinity capture matrices in microfabricated chambers having antibodies targeted to the various classes of microbiological organisms such as bacteria, viruses and bacterial spores. The immunoaffinity chambers can capture, purify, and concentrate the target for further analysis steps.
Owner:RGT UNIV OF CALIFORNIA
Method and device for ultrasonically manipulating particles within a fluid
InactiveUS20060037915A1Easy to operateAuxillary pretreatmentShaking/oscillating/vibrating mixersSolid phase extractionBiological particles
Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and / or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.
Owner:PROTASIS CORP
Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
ActiveUS20070217963A1Efficient processingShort timeShaking/oscillating/vibrating mixersTransportation and packagingChemical reactionRadioactive decay
Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC +1
Method and apparatus for preparing platelet rich plasma and concentrates thereof
ActiveUS20060175242A1Shaking/oscillating/vibrating mixersTransportation and packagingFiberRed blood cell
The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
Owner:HANUMAN +1
Apparatus and method for resonant-vibratory mixing
ActiveUS7188993B1Reduce the overall heightImprove bearing lifeShaking/oscillating/vibrating mixersTransportation and packagingLinear motionElectronic controller
An apparatus and method for mixing fluids and / or solids in a manner that can be varied from maintaining the integrity of fragile molecular and biological materials in the mixing vessel to homogenizing heavy aggregate material by supplying large amounts of energy. Variation in the manner of mixing is accomplished using an electronic controller to generate signals to control the frequency and amplitude of the motor(s), which drive an unbalanced shaft assembly to produce a linear vibratory motion. The motor may be a stepper motors a linear motor or a DC continuous motor. By placing a sensor on the mixing vessel platform to provide feedback control of the mixing motor, the characteristics of agitation in the fluid or solid can be adjusted to optimize the degree of mixing and produce a high quality mixant.
Owner:RESODYN ACOUSTIC MIXERS
Method and system for microfluidic interfacing to arrays
InactiveUS7223363B2Reduce amountLower the volumeShaking/oscillating/vibrating mixersFlow mixersChemical reactionComputer module
A method and system for providing a fluidic interface to slides bearing microarrays of biomolecules or other samples immobilized thereon to perform a variety of chemical reactions or processing steps on the slide. An interface device seals against the slide to form a chamber or chambers containing all or a portion of the microarray, providing selective access to portions of the slide. The interface device includes inlet and outlet ports permitting liquid sample and reagents to be introduced to and removed from the chamber accessing the slide surface. Pre- and post-array microfluidic circuitry may be included in the interface device or in attachable modules. The system may include one or more compartments for collecting and storing waste fluids.
Owner:ROCHE NIMBLEGEN
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