259 results about "Microreactor" patented technology

The invention discloses a microfluidic nitration reaction platform based on in-situ Raman and a reaction optimization method. The platform integrates a microreactor, an in-situ Raman detection module, a spectrogram processing and quantifying module, an experimental optimization module and a central control module, and is suitable for monitoring and optimizing complex reactions under a non-mutual solution phase plunger flow system. According to the method, an indirect hard modeling (IHM) method is used for processing an overlapped Raman spectrogram, a standard curve is combined for establishing a multi-component concentration prediction model, and high-precision quantification of reactants and products is realized. According to the platform, a Gaussian process model is combined with dynamics prior, a multi-target Bayesian optimization process based on expected hypervolume improvement (EHVI) is driven, and Pareto optimal conditions in a temperature and residence time space are effectively explored. The system has the functions of automatic focusing sampling, spectrogram real-time decoupling, concentration inversion and experimental condition decision making, and is suitable for intelligent reaction development and optimization in the fields of fine chemical engineering, high-throughput reaction screening and the like.

The invention provides bionic fractal micro-channel reactor equipment for fluid fuel hydrogen production, which is particularly suitable for marine mobile hydrogen production scenes such as a ship power system and an offshore hydrogen refueling station. The microreactor adopts an upper, middle and lower layer functional structure design, and comprises a diversion diffusion area, a chemical reaction area and a product buffer collection area, the diversion diffusion area and the product buffer collection area are fractal tree-shaped microchannels with optimal continuous length ratio and mass diffusion flux, and the diffusion resistance of reactants can be remarkably reduced. By virtue of the characteristics of compact structure, vibration resistance and easiness in integration of the fractal microchannel, uniform distribution and efficient transportation of reactants are realized, heat and mass transfer performance can be enhanced under harsh working conditions of the ocean, and hydrogen production efficiency and system reliability are improved by combining efficient heat source supply and fuel conversion processes; and the requirements of an ocean mobile platform on efficient, compact and stable hydrogen production equipment are met.

The invention discloses a continuous hydrogenation device and process. The continuous hydrogenation device comprises a gas supply system, a liquid supply system, a heating system, a hydrogenation reactor, a gas-liquid mixing distributor, a cooling system, a gas-liquid separation system and a product collection system, the gas supply system and the liquid supply system are respectively connected with an inlet of the gas-liquid mixing distributor through pipelines, and an outlet of the gas-liquid mixing distributor is connected with an inlet of the reactor through a pipeline; a first spacer bush and a second spacer bush which are concentrically distributed are arranged in the reactor to form an S-shaped circulation channel, so that the retention time of materials is prolonged; meanwhile, various catalytic structures are provided, such as a micro-reaction channel with a catalyst coating on the inner wall, a filling type catalyst layer and a multi-stage micro-reactor, the contact area of raw materials and a catalyst is increased, the reaction conversion rate is increased, a crescent flow blocking column is arranged in a thick-section channel of the multi-stage micro-reactor, the gas-liquid mixing uniformity can be further enhanced, and the gas-liquid mixing efficiency is improved. Incomplete local reaction is avoided, and the product purity is improved.

The invention belongs to the field of chemical engineering, and relates to a process device and method for continuously synthesizing glycidyl (3-chloro-1, 2-propylene glycol and sodium hydroxide (hereinafter referred to as NaOH) as raw materials). The device comprises a raw material feeding pump, a heat exchanger, a micro-reactor, a delay tube reactor 1, a neutralization micro-reactor and a delay tube reactor 2 which are sequentially in fluid communication through pipelines, the heat exchangers are divided into two groups, one group is used for heat exchange of 3-chloro-1, 2-propylene glycol solution, and the other group is used for heat exchange of alkaline solution. According to the method, a 3-chloro-1, 2-propylene glycol solution and a sodium hydroxide solution (NaOH) are adopted as raw materials, glycidol is continuously prepared through a microchannel reactor, on the basis, an acid-base neutralization reaction can be carried out in situ according to needs to remove redundant alkali, redundant heat generated by the acid-base neutralization reaction is absorbed through a low-temperature material, and energy consumption is reduced; the product is analyzed by gas chromatography, and the generated glycidol does not have hydrolysates or auto-polymerization products, so that the product selectivity is higher.

The present invention relates to a multistage series microreactor and a fluid mixing method. The microreactor includes a base internally etched with a fluid passage, the base being provided with a fluid inlet and a fluid outlet which are communicated with the fluid passage, where the fluid passage includes a plurality of micro mixing tanks, a jet port is formed at an inlet of the micro mixing tank, adjacent micro mixing tanks are connected by jet port at a contraction section, and a splayed flow baffle plate and a flow splitting column which are arranged corresponding to the jet port are provided in the micro mixing tank, the flow splitting column being arranged below the splayed flow baffle plate. By means of a jet manner, a fluid to be mixed in the invention can be continuously split, compounded, stretched and crushed, thereby realizing rapid mixing and efficient, continuous reaction.

The invention discloses superfine copper powder and a preparation method and application thereof, and belongs to the technical field of copper powder.The preparation method of the superfine copper powder comprises the following steps that a micro-channel reactor is provided, and the micro-channel reactor comprises a micro-mixer and a micro-reactor which are connected with each other; a copper salt solution, a reducing agent solution and a sodium hydroxide solution are injected into a micro-channel reactor to be evenly mixed, a mixed solution is obtained and then enters the micro-channel reactor to be subjected to a reaction, discharging is conducted, and the superfine copper powder is obtained. The injection flow rate ratio of the sodium hydroxide solution to the copper salt solution to the reducing agent solution is (0.5-2): (0.8-1.2): (0.8-1.2). According to the method, the uniformity and the preparation efficiency of the superfine copper powder are remarkably improved, meanwhile, the reaction time is greatly shortened, the yield and the purity of the superfine copper powder are remarkably improved, continuous and efficient preparation of the superfine copper powder is achieved, and the method has wide application prospects.

The invention discloses a Pickering IL emulsion microreactor constructed on the basis of temperature-sensitive double-enzyme Janus spheres and application of the Pickering IL emulsion microreactor to enhanced catalysis of conversion of CO2 into formic acid. A Janus emulsion template method is combined with a photocuring technology to synthesize a nano-scale dual-functional temperature-sensitive Janus sphere, one half of the nano-scale dual-functional temperature-sensitive Janus sphere is a hydrophilic hydrocarbon polymer, the other half of the nano-scale dual-functional temperature-sensitive Janus sphere is a hydrophobic fluorocarbon polymer, and rapid inversion of a Pickering emulsion can be realized by utilizing temperature sensitivity. The method comprises the following steps: preparing a Janus particle hydrophilic / hydrophobic hemisphere, selectively immobilizing formate dehydrogenase FDH and carbonic anhydrase CA on the Janus particle hydrophilic / hydrophobic hemisphere to obtain a temperature-sensitive FDH-Janus-CA composite sphere, introducing a fluorine-functionalized ionic liquid to regulate and control the internal microenvironment of a microreactor, and constructing a Pickering IL emulsion microreactor. The CO2 absorption capacity is increased by 47 times compared with that of a pure water system, the formic acid yield reaches 27.5 mM and is higher than the maximum value 22.8 mM of current enzyme electrocatalysis, the storage and catalysis stability is good, and an efficient and sustainable scheme is provided for CO2 recycling.

The invention provides a preparation method and application of novel acrylic continuous pre-polymerized resin. The preparation method comprises the following steps: preheating an MMA solution containing azodiisobutyronitrile to 50-60 DEG C, and enabling the preheated MMA solution to flow into the microreactor main body; the pure MMA is preheated to 90-95 DEG C and then flows into the microreactor main body; and mixing the inflowing materials, controlling the reaction temperature to be 120-130 DEG C, the pressure to be 0.2-0.3 MPa and the retention time to be 5-15 minutes, and carrying out continuous polymerization reaction to prepare the PMMA prepolymer resin. According to the technology, accurate regulation and control of the molecular weight and distribution of the PMMA / MMA prepolymer are realized through a continuous process under high temperature and high pressure, and the goal can be achieved without depending on a chain transfer agent. The method is safe and controllable, the product of the method is perfectly compatible with a solid plane material curing system of'an initiator first and then an accelerant ', and the energy consumption and the safety risk are effectively reduced while the production efficiency and the productivity are remarkably improved.

The present invention relates to the technical field of high polymer material synthesis, and discloses an anti-clogging microreactor for high viscosity silicone rubber synthesis, the anti-clogging microreactor comprises a microreactor chip, and the interior of the microreactor chip is provided with a tree-shaped bifurcated microchannel network based on fractal structure design; the invention relates to a continuous preparation method of an anti-clogging microreactor for synthesizing high-viscosity silicone rubber. The continuous preparation method comprises the following steps: S1, precisely metering a methyl cyclosiloxane monomer and a vinyl siloxane monomer, and then inputting the methyl cyclosiloxane monomer and the vinyl siloxane monomer into the microreactor; s2, carrying out a controllable ring-opening polymerization reaction in the microchannel; and S3, quickly terminating the reaction by injecting a terminating agent on line, and controlling the molecular weight and distribution of the polymer. Compared with the prior art, the method has the advantages that the problems that an existing microreactor is prone to blockage and difficult to operate stably for a long time when treating a high-viscosity siloxane polymerization system are solved, meanwhile, the method can achieve accurate control over product quality and continuity and intellectualization of the production process, the production efficiency is remarkably improved, and energy consumption is reduced.

The invention discloses an ultrasonic microreactor, system and method for preparing perovskite quantum dots. The ultrasonic microreactor comprises at least two feeding inlet ends, a discharging outlet end, a microchannel structure and an array microstructure. The micro-channel structure comprises a main channel and a plurality of branch channels, the main channel comprises a flow dividing section and a flow converging section, the flow dividing section is communicated with the feeding inlet end, the flow converging section is communicated with the discharging outlet end, and the inlet ends of the branch channels are arranged at intervals in the internal flowing direction of the flow dividing section; the outlet ends of the branch channels are arranged at intervals in the internal flowing direction of the confluence section, and the array microstructure comprises a plurality of three-dimensional protruding units arranged on the inner walls of the main channel and the branch channels in a protruding mode. Under the action of an ultrasonic field, the local shearing, turbulence and cavitation intensity is remarkably enhanced, so that rapid mixing and mass transfer enhancement of reactants under the micro-scale are realized, and continuous-flow and highly-controllable preparation of perovskite quantum dots is realized.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a process for preparing fipronil and an intermediate thereof. Toxic 1, 2-dichloroethane is comprehensively replaced by bio-based gamma-valerolactone, low-toxicity cyclopentyl methyl ether is matched, and N, N-dimethylformamide necessary for the process is recycled, so that consumption is greatly reduced; the continuous processes of amination, diazotization and the like are realized through a tubular reactor, a micro-reactor and a static mixer, and separation technologies such as pervaporation membrane and vacuum distillation are combined, so that the reaction time is shortened, the solvent recovery rate is increased, and the production is promoted to be continuously transformed to green. The supported FeCl3 / SiO2-NH2 catalyst disclosed by the invention can be repeatedly used, and byproducts and tail gas can be recycled and reused. In addition, diazonium salt residues are controlled to be smaller than or equal to 0.5% through near infrared spectroscopy, citric acid is subjected to stable oxidation reaction, a purification process is combined, it is ensured that the finished product is high in purity, excellent in yield and small in batch fluctuation, and efficiency and safety are both considered.

The application provides a heat pipe micro reactor steady-state multi-physical coupling method and system based on a fission response function, which integrates a fission response function physical program, a self-developed Unifoam finite element thermal program and a heat pipe program, realizes steady-state joint solution of three physical fields of nuclear neutronics, solid thermal engineering and heat pipe two-phase flow through a coupling iterative driving script, and obtains accurate power field and temperature field distribution of the heat pipe micro reactor under a steady-state working condition. The method pre-constructs a high-fidelity fission response function database through a Monte Carlo method, does not need to repeatedly perform a complex particle transport process during operation, and only needs to complete neutronics solution through matrix multiplication, so that the simulation accuracy and the calculation efficiency are effectively balanced.

The utility model relates to the technical field of chemical equipment, and discloses a microreactor for a high-viscosity reaction system, which comprises a feeding end cover (2), a discharging end cover (9), a primary reactor (4), a secondary reactor (8), an interstage connector I (6), an interstage connector II (18) and a crossover line (7), the feeding end cover (2) is arranged at the inlet end of the first-stage reactor (4), the first-stage reactor (4) and the second-stage reactor (8) are connected through the overline (7), the first-stage reactor (4) and the overline (7) are connected through the interstage connector I (6), and the second-stage reactor (8) and the overline (7) are connected through the interstage connector II (18); concave sealing pieces (3) are arranged on the inner walls of the interstage connector I (6) and the interstage connector II (18), and the concave corners are chamfered; and a discharge end cover (9) is arranged at the outlet end of the secondary reactor (8). The reactor weight is reduced, and the application is flexible and convenient.

The present application relates to the field of micro-reactor, and discloses a double-layer composite micro-reaction channel plate with three-dimensional stepped channels and a micro-channel reactor.The double-layer composite micro-reaction channel plate comprises an upper channel plate and a lower channel plate which are superimposed;the top surface of the upper channel plate is provided with heat exchange channels A, and the bottom surface is provided with a first fluid inlet;the first fluid pre-heat exchange channel;the second fluid inlet;the second fluid pre-heat exchange channel;the mixing channel;and the mixed fluid outlet.A plurality of stepped cavities A are staggered along the flow direction at the bottom of the mixing channel.The bottom surface of the lower channel plate is provided with heat exchange channels B, and the top surface is provided with stepped cavities B which correspond to the positions and sizes of the stepped cavities A one by one.The double-layer composite micro-reaction channel plate of the present application is provided with special three-dimensional stepped channels, and the mixed fluid will produce fluctuation when passing through the structure, which can greatly enhance the disturbance of the fluid under the premise of not increasing the fluid resistance, so that the advection becomes turbulent flow, and the mixing effect is significantly enhanced.

The application discloses a detachable laminated staggered-hole mixed core micro-reactor, which comprises a rectangular flat tube-shaped outer sleeve and a plurality of laminated rectangular staggered-hole inserts inserted into the inner cavity of the outer sleeve. The rectangular staggered-hole inserts are provided with a plurality of transverse rows of protruding hole channels or concave hole channels, and the protruding hole channels on adjacent transverse rows are staggered. The laminated staggered-hole mixed core and the rectangular flat channel of the outer sleeve are matched with each other, the mixing and heat exchange performance of the process in the micro-reactor is obviously improved, and the mixed core is more convenient to assemble, disassemble, clean and maintain, especially the staggered hole channels and the interlayer turbulence effectively promote the mixing of the internal fluid. The laminated staggered-hole mixed core can meet the individualization and customization while being mass-produced. Different specifications of the staggered-hole cores can be combined for use, and the single standard core is convenient for testing and obtaining experience data, and is convenient for operators to replace different specifications according to needs in daily use.

The utility model provides a continuous flow micro-reactor for a heparinase catalytic reaction, belongs to the technical field of micro-reactors, and aims to solve the problems that the replacement of immobilized heparinase needs a long time and the efficiency of the heparinase catalytic reaction is influenced. Comprising a limiting supporting base, a positioning mounting frame, a reactor main body, a positioning connecting rod, a first storage tank and a second storage tank, the positioning mounting frame is in bolted connection with the right side of the limiting supporting base; the reactor main body is fixedly connected to the left side of the positioning mounting frame; the positioning connecting rod is rotationally connected to the left side of the reactor main body, and a damper is arranged at the joint of the positioning connecting rod and the reactor main body; the first storage tank is fixedly connected to the middle part of the positioning connecting rod; the second storage tank is in bolted connection with the front side of the first storage tank; according to the utility model, the replacement efficiency of the immobilized heparinase is improved, a large amount of time is saved, and the catalytic reaction efficiency of the heparinase is improved.

The application discloses a liquid heavy metal cooling micro small reactor control rod drive mechanism which is composed of a motor drive transmission mechanism, an outer cylinder, a supporting cylinder, a rod position measurer, an electromagnetic clutch mechanism, a screw rod connecting rod, a guide pipe and a gas protection system; a speed reducer and a drive motor in the motor drive transmission mechanism are installed upside down at the lower end of a gear transmission box in sequence, a rotating cylinder is coaxially installed in the outer cylinder and is installed at the lower end of the gear transmission box through a connector at the upper end; the rod position measurer is fixedly installed on the outer wall of the outer cylinder; the electromagnetic clutch mechanism is fixedly installed at the lower end of the outer cylinder and the rotating cylinder; the lower end of the screw rod connecting rod is fixedly connected with a control rod, and the upper part is in screw thread cooperation with a ball nut of the electromagnetic clutch mechanism. The single motor and the electromagnetic clutch mechanism are adopted, the liquid heavy metal buoyancy is fully utilized, the spring is assisted, the control rod adjusting and falling rod functions are realized, the height and weight above the top cover are reduced, the metal vapor is avoided from escaping through the gas protection system, the structure is compact, and the safety and reliability are high.

The invention relates to the field of lily pyran production, and discloses a method for obtaining lily pyran by acidifying and hydrolyzing a rectification backing material, which comprises the following steps: S1, raw material proportioning and reaction starting: respectively pumping the lily pyran rectification backing material and an acid catalyst solution into a microreactor from two feeding channels according to a mass ratio of 1.0: (0.7-1.0); s2, continuous feeding: in the process of pumping the valley pyran rectification base material and the acid catalyst solution in the step S1 into the microreactor along two feeding channels, respectively controlling the feeding speeds, and mixing in the microreactor to obtain a mixture; according to the method, available components such as uncyclized precursors and oligomers in the rectified backing material are directionally converted through an acidification hydrolysis process, the backing material treated as hazardous waste in a traditional process is converted into a convallaria majalis pyrane finished product, the total utilization rate of raw materials is remarkably increased, and thousands of tons of resource waste is reduced every year; meanwhile, the hazardous waste incineration or landfill cost is saved, and the economic burden is further reduced.

The invention discloses a multi-channel micro-reactor and an application method thereof. The multi-channel micro-reactor comprises an inlet section (8), a mixing section (22), a reaction section (5) and an outlet section (3) which are communicated in sequence, wherein a first fluid inlet (2) is formed in the bottom of the inlet section; a mixing channel (23) is arranged in the mixing section, the bottom of the mixing channel penetrates through a first pore plate (17) to be communicated with the inlet section, distribution holes (11) are formed in the pipe wall of the mixing channel, and a second fluid inlet (14) is formed in the side wall of the mixing section; a reaction channel (6) and a heat exchange channel are arranged in the reaction section, the bottom of the reaction channel is communicated with the mixing channel through a second pore plate (18), and the heat exchange channel is provided with a heat exchange medium inlet (12) and a heat exchange medium outlet (13); the outlet section is provided with a top outlet (1), and the bottom of the outlet section is communicated with the reaction channel through a third pore plate (4). The multi-channel microreactor provided by the invention can be used for continuous reaction processes of gas-liquid, liquid-liquid, gas-liquid-liquid or gas-liquid-solid and other multi-phase systems.

The invention discloses a method and a system for preparing a 4-AA medical intermediate through continuous flow ozone oxidation. The method comprises the following steps: continuously introducing a raw material solution containing (3R)-3-((R)-1-((tert-butyldimethylsilyl) oxy) ethyl)-1-(4-methoxyphenyl)-4-oxo azetidine-2-yl acetate and a gas containing ozone into a microreactor for reaction; after the reaction liquid is subjected to reduction quenching, the (3R, 4R) 4-acetoxyl-3-[R-(tert-butyldimethylsiloxy) ethyl]-2-azetidinone is obtained. On one hand, the reaction time is shortened from the hour level to the minute level, and the production efficiency is remarkably improved; and on the other hand, the reaction temperature is increased to 10-30 DEG C from deep cooling, so that the refrigeration energy consumption and the equipment requirement are greatly reduced. According to the invention, local peroxidation is fundamentally avoided, byproducts are obviously reduced, the product purity is improved, the method is suitable for continuous operation, the reaction process is controllable, and the method is safe and reliable.

The invention discloses a micro-channel reactor system for continuous preparation of a drug nano-preparation, and relates to the technical field of micro-reactors, the micro-channel reactor system comprises micro-reactor equipment and a control assembly, the micro-reactor equipment is provided with a reaction medium inlet, a reaction medium outlet, a heat exchange medium inlet and a heat exchange medium outlet; the control assembly comprises an industrial personal computer, an air compressor, a booster pump, a pressure reducing valve, a gas mass flow meter, a high-pressure constant-current infusion pump, a back pressure valve and a high-low temperature all-in-one machine, the air compressor, the booster pump, the pressure reducing valve and the gas mass flow meter are sequentially connected, and the gas mass flow meter and the high-pressure constant-current infusion pump are respectively connected with the reaction medium inlet; the back pressure valve is connected with the reaction medium outlet, and the high and low temperature all-in-one machine is connected with the heat exchange medium inlet and the heat exchange medium outlet. Accurate automatic control is carried out on operation of the microreactor equipment through the control assembly, continuous preparation of nano-drugs is achieved, the production yield and efficiency are remarkably improved, and meanwhile the automatic control level is improved.

The application is a kind of continuous preparation method and application of core-shell type reduced Cu-based catalyst. The method uses membrane dispersion micro-reactor technology, adopts liquid phase chemical reduction method with potassium borohydride-hydrazine hydrate as double reducing agent, continuously prepares reduced Cu-based nanoscale catalyst, does not need high temperature calcination and hydrogen reduction, can be directly used as active catalyst for catalytic reaction, and realizes green and efficient preparation. The catalyst prepared by the application is used in the reaction of preparing N-butyl-2,2,6,6-tetramethyl-4-piperidinamine from 2,2,6,6-tetramethyl-4-piperidinone and n-butylamine through reductive amination, and excellent catalytic activity and stability are shown.

This invention discloses a green synthesis process for 2-chloropyranose-1-yl)-4'-ethoxydiphenylmethane, belonging to the field of pharmaceutical intermediate preparation. The method involves forming a mixture of a substrate in the protected state of Formula I and a reducing agent containing siloxane bonds, which is continuously fed into a microreactor loaded with a confined-domain MOF (Metal-Oxide-Fractions) supported catalyst for room-temperature reduction. The MOF catalyst has a rigid pore size of 1.2~2.5 nm and internally coordinates and anchors metal trifluoromethanesulfonate. This invention utilizes the limiting confinement effect of rigid channels to lock the substrate conformation, blocking the surface attack of reactants and achieving extremely high configuration selectivity. Simultaneously, the efficient mass transfer of the continuous flow microchannel and the online infrared spectroscopy closed-loop control system completely eliminate the need for traditional cryogenic conditions, remove highly corrosive fluorine-containing waste liquid, significantly reduce synthesis costs, and achieve efficient, green, and stable continuous industrial production of this core intermediate.

The invention provides a method for preparing sodium diisobutyl dithiophosphinate by using a microreactor, and belongs to the technical field of organic synthesis. The method comprises the following steps: sequentially carrying out impurity removal pretreatment, precooling drying and deep cooling on phosphine gas to obtain high-purity liquid phosphine, the method comprises the following steps: by taking liquid phosphine and isobutene as raw materials, adding an initiator, and carrying out photo-thermal synergistic initiated free radical addition reaction in a microreactor to synthesize diisobutyl phosphorus; the micro-reactor comprises a straight-through pre-activation zone, a transition reaction zone and a main reaction zone; rectifying and separating the diisobutyl phosphorus; the preparation method comprises the following steps: adding diisobutyl phosphorus and a sodium hydroxide solution into a sulfur source solution under the conditions of pressurization and heating, carrying out nucleophilic substitution reaction, and carrying out heat preservation reaction to obtain the sodium diisobutyl dithiophosphinate. The free radical addition reaction is carried out in the microreactor, and step-by-step operation initiated by photo-thermal synergy is adopted, so that the yield of the target product diisobutyl phosphorus of the reaction is effectively improved, the generation of by-products is inhibited, and the blockage of the microreactor is avoided.

The invention relates to the technical field of medicament synthesis, and particularly discloses a microreactor device for preparing liquid isopropyl xanthate, the microreactor device comprises a workbench, the top of the workbench is fixedly connected with a mixing tank through a support, and the two sides and one end of the mixing tank are communicated with feeding pipes; the end, away from the mixing tank, of the feeding pipe communicates with a discharging port of a metering pump, the bottom of the metering pump is fixedly connected with the top of the workbench, the inner wall of the mixing tank is rotationally connected with a mixing device, and the part, located below the mixing tank, of the top of the workbench is fixedly connected with a first motor. According to the microreactor device for preparing the liquid isopropyl xanthate, the mixing device is arranged, so that the mixing efficiency of isopropanol, carbon disulfide and liquid caustic soda before reaction can be improved, and the dosing mechanism is arranged, so that the mixing efficiency of isopropanol, carbon disulfide and liquid caustic soda before reaction can be improved. Therefore, the reaction efficiency of the mixed solution of isopropanol, carbon disulfide and caustic soda liquid during reaction can be improved.

This invention discloses a hierarchical coordinated control method and system for gas-cooled microreactors using deep reinforcement learning, belonging to the field of nuclear reactor control technology. The method constructs a three-layer architecture comprising an intelligent decision-making layer, a signal processing layer, and a PID controller layer. It utilizes a SAC (Smart Agent Control) agent to optimize the incremental output of electrical power and outlet temperature based on the gas-cooled microreactor's thermal parameters. The signal processing layer performs rate limiting and low-pass filtering on the optimized incremental output to generate a smooth setpoint command. The bottom-layer PID controller then outputs turbine speed and airflow signals to perform load tracking. This invention integrates the advantages of deep reinforcement learning in handling strong coupling and nonlinear dynamics with the robustness of traditional PID control. Through a physical constraint layer, it effectively suppresses oscillations and overshoot of the AI ​​control signal, achieving fast, smooth, and safe decoupled control of the gas-cooled microreactor across the entire power range, significantly improving load tracking performance and extending actuator life.

The invention belongs to the technical field of synthesis of fine chemical intermediates, and particularly relates to a continuous flow synthesis method and device of 2-methylbenzoquinone. The method comprises the following steps: a) dissolving 2-methylphenol and a Schiff base cobalt catalyst in an organic solvent to prepare a raw material solution; b) conveying the raw material liquid to a microreactor by using a pump, mixing the raw material liquid with oxygen or air in the conveying process, and then carrying out continuous oxidation reaction under certain reaction conditions to generate 2-methylbenzoquinone; and c) separating and purifying the reaction product to obtain the 2-methylbenzoquinone product.The micro-channel reactor is adopted to strengthen mass transfer and reduce the safety risk, the Schiff base cobalt is used as the catalyst, air or oxygen is used as the oxidizing agent, the reaction efficiency and yield are improved, pollution is reduced, and efficient, green and safe production is achieved.

This invention discloses a method for controllable preparation of nanoparticles using a multi-channel microreactor. The method utilizes a microchannel reactor to segment droplets and prepare quantitatively synthesized nanoparticles with controllable particle size. The invention employs capillary action to draw the reaction solution into the microchannel, segmenting one or more droplets (each droplet into 10-100 portions). By changing the width of the microchannel, controllable preparation of nanoparticles within a small range (±3 nm) can be achieved; by changing the length of the microchannel, controllable preparation of nanoparticles within a large range (±10-30 nm) can be achieved. Furthermore, the reactor structure of this invention is simple, enabling highly precise and quantitative synthesis of various nanoparticles. Compared to large-scale reactors, the miniaturization of the synthesis reaction in this invention effectively reduces energy waste and safety hazards, making it highly valuable for applications in safe chemical engineering, green chemical engineering, high-efficiency chemical engineering, microchemical engineering, and precise reaction monitoring.

The present application relates to the technical field of synthesis of nitrogen-containing heterocyclic compounds, and particularly relates to a continuous flow synthesis method of nitrogen-containing heterocyclic acetic acid; specifically, nitrogen-containing heterocyclic compounds, halogenated acetic acid ester and inorganic acid binding agent are mixed in an aprotic solvent, and then are introduced into a microchannel of an ultrasonic microchannel continuous flow reactor to perform a substitution reaction under ultrasonic cavitation; after the reaction, the reaction liquid is collected and post-treated to obtain a nitrogen-containing heterocyclic acetic acid ester intermediate; the nitrogen-containing heterocyclic acetic acid ester intermediate is introduced into a second microreactor using an inorganic lye to perform a hydrolysis reaction, and after the reaction, the reaction liquid is collected and post-treated to obtain the nitrogen-containing heterocyclic acetic acid; the present application realizes continuous flow reaction of a heterogeneous system by using emulsification and ultrasonic technology, and can be used for the next step of continuous flow hydrolysis reaction after simple filtration and separation; the present application has high yield of two-step reaction, simple separation, short reaction time, and is suitable for large-scale industrial production.

The invention discloses a method for efficiently and continuously hydrogenating and synthesizing hydrogenated bisphenol A through an ultrasonic-assisted microreactor, and belongs to the technical field of chemical reaction engineering. Aiming at the problems of easy excessive hydrogenation of products and many byproducts caused by slow multiphase mass transfer speed and long reaction time in the hydrogenated bisphenol A synthesis process, the invention adopts an ultrasonic-assisted microreactor technology to further enhance the gas-liquid-solid three-phase mass transfer efficiency, reduce the reaction time and temperature, and improve the yield of hydrogenated bisphenol A. Therefore, high-efficiency hydrogenation is realized under mild conditions, and the product yield and safety are improved. Compared with a common hydrogenation reactor, the method is based on an ultrasonic-assisted microreactor strengthening strategy, the reaction time is shortened to be within 2 minutes, complete conversion of raw materials is achieved, and the product purity is higher than 99%. The method provided by the invention realizes continuous and automatic operation of bisphenol A hydrogenation reaction, has remarkable economical efficiency, green environmental protection property and safety, and is suitable for large-scale industrial production.