467 results about "Microreactor" patented technology

A nuclear reactor is discussed herein. In some examples, the nuclear reactor may comprise an inner-core region, including liquid fuel, coolant / moderator, and a hydrogen vapor space, an out-of-core region surrounding the inner-core region, the out-of-core region including, an inner reflector adjacent to the inner-core region, the inner reflector including a first irradiation facility, and an outer reflector adjacent to the inner reflector, the outer reflector including a second irradiation facility.

The invention relates to a method for continuously synthesizing a dapagliflozin intermediate, and belongs to the technical field of drug intermediate synthesis. The method comprises the following steps: mixing 5-bromo-2-chloro-4 '-ethoxydiphenylmethane, a photocatalyst and THF (tetrahydrofuran), introducing the mixture into an ultraviolet light catalytic micro-channel for pre-activation to generate an aryl free radical intermediate, namely a pre-activation solution, carrying out contact reaction on the pre-activation solution and a THF solution of 2, 3, 4, 6-tetra-O-trimethylsilyl-D-glucolactone in a low-temperature coupling area of a micro-reactor, and carrying out purification, purification and purification to obtain the aryl free radical intermediate. The reaction liquid is introduced into a dynamic quenching zone and is mixed with supercritical CO2 on line, an intermediate I is obtained through supercritical fluid extraction and separation, and the photocatalyst is recycled; the method has the advantages of high reaction efficiency, convenience in catalyst recovery and simplicity in product separation.

The invention relates to the field of caprolactam production, and discloses a green and efficient production process and device. The process comprises the following steps: continuously oximating cyclohexanone and hydroxylamine in a microreactor under the catalysis of mesoporous silica solid acid; carrying out gas phase rearrangement on cyclohexanone-oxime in the presence of a ZSM-5 molecular sieve under the assistance of microwaves; coupling, rectifying and purifying the crude product through a four-stage molecular sieve membrane; and performing catalytic cracking on the by-product to obtain N2 / H2O and recycling. The device comprises a micro-reaction unit, a microwave-radial reactor, a membrane coupling rectifying tower group and a tail gas cracking unit. Zero emission of ammonium sulfate is achieved, the product purity is larger than or equal to 99.95%, and energy consumption is reduced by 45%.

The invention discloses a multi-component atomic level oxide solid solution integrated electrode for electrolyzed water and a preparation method thereof, and belongs to the field of metal material surface plating. The electrode is composed of a gas diffusion layer, a nano array substrate and an atomic level oxide solid solution catalyst layer. The preparation method comprises the following steps: constructing a nano array microreactor on the surface of the gas diffusion layer; the method comprises the following steps: driving an atomic hierarchy solid solution to reconstruct by utilizing an array confinement effect through combination of precursor directional spraying and a heat treatment-rapid quenching process, and constructing a three-dimensional conformal ionomer network on the surface of the atomic hierarchy solid solution; and performing gold plating treatment on the back side of the electrode. Through the synergistic effect of spatial constraint and thermodynamic regulation of the nano microreactor, the traditional electrode interface mismatch bottleneck is broken through, and while precise construction of atomic-scale active sites is realized, the mechanical stability and oxygen evolution reaction kinetics of the electrode are improved. The preparation process has the advantages of controllable flow, strong large-scale expansibility and good industrial preparation prospect.

The invention discloses a microfluidic nitration reaction platform based on in-situ Raman and a reaction optimization method. The platform integrates a microreactor, an in-situ Raman detection module, a spectrogram processing and quantifying module, an experimental optimization module and a central control module, and is suitable for monitoring and optimizing complex reactions under a non-mutual solution phase plunger flow system. According to the method, an indirect hard modeling (IHM) method is used for processing an overlapped Raman spectrogram, a standard curve is combined for establishing a multi-component concentration prediction model, and high-precision quantification of reactants and products is realized. According to the platform, a Gaussian process model is combined with dynamics prior, a multi-target Bayesian optimization process based on expected hypervolume improvement (EHVI) is driven, and Pareto optimal conditions in a temperature and residence time space are effectively explored. The system has the functions of automatic focusing sampling, spectrogram real-time decoupling, concentration inversion and experimental condition decision making, and is suitable for intelligent reaction development and optimization in the fields of fine chemical engineering, high-throughput reaction screening and the like.

The invention discloses a nano cerium oxide synthesis method which comprises the following steps: preparing a reaction solution; performing ultrasonic reaction; carrying out aging treatment; centrifugally washing; drying and calcining; the cerium salt solution is prepared from soluble cerium salt, and the concentration of the cerium salt solution is 0.01 mol / L to 1 mol / L; the precipitant solution is one or more of ammonia water, a sodium hydroxide solution, a sodium carbonate solution and a sodium bicarbonate solution, and the concentration of the precipitant solution is 0.2 mol / L-8 mol / L; the ultrasonic power of the ultrasonic microreactor is 10W to 1000W; the calcining temperature ranges from 400 DEG C to 1000 DEG C. The nano cerium oxide with less agglomeration, controllable particle size, uniform size and adjustable morphology is obtained on the basis of super-strong mixing and crystallization promoting capabilities of the ultrasonic microreactor. Meanwhile, the method is simple and convenient to operate, easy to amplify and convenient for industrial production.

The utility model discloses an ultrasonic microreactor which is formed by directly attaching an ultrasonic transducer and a microreactor, the ultrasonic microreactor is formed by connecting a plurality of fluid microchannel reaction layers in series; the fluid micro-channel reaction layer is formed by alternately connecting a plurality of thin channels and thick channels; a reaction layer turbulent flow chip is arranged in the middle of the thick channel; under the synergistic effect of ultrasound and the microreactor, the ultrasonic microreactor has higher energy density and more accurate sound field and flow field regulation and control capability, and can solve the problems that channels are easy to block and the like, so that nano-emulsion with uniform particle size can be continuously prepared, and the efficiency of an emulsification process and the quality of an emulsion product are improved.

The invention discloses a preparation method for regulating the morphology of zinc oxide, and belongs to the technical field of metal oxides, and the preparation method comprises the following steps: (1) preparing a zinc salt solution and an alkaline solution; (2) respectively inputting the zinc salt solution and the alkaline solution into an ultrasonic microreactor, enabling the zinc salt solution and the alkaline solution to be in contact in the conveying process in the ultrasonic microreactor, and reacting under the ultrasonic action to form zinc oxide slurry; and (3) outputting the zinc oxide slurry from the ultrasonic microreactor, filtering, washing, drying, crushing, and screening to obtain the zinc oxide powder. Controllable synthesis of nano-zinc oxide with different morphologies is realized by utilizing the super-strong mixing capacity of the ultrasonic pipeline reactor.

The invention provides bionic fractal micro-channel reactor equipment for fluid fuel hydrogen production, which is particularly suitable for marine mobile hydrogen production scenes such as a ship power system and an offshore hydrogen refueling station. The microreactor adopts an upper, middle and lower layer functional structure design, and comprises a diversion diffusion area, a chemical reaction area and a product buffer collection area, the diversion diffusion area and the product buffer collection area are fractal tree-shaped microchannels with optimal continuous length ratio and mass diffusion flux, and the diffusion resistance of reactants can be remarkably reduced. By virtue of the characteristics of compact structure, vibration resistance and easiness in integration of the fractal microchannel, uniform distribution and efficient transportation of reactants are realized, heat and mass transfer performance can be enhanced under harsh working conditions of the ocean, and hydrogen production efficiency and system reliability are improved by combining efficient heat source supply and fuel conversion processes; and the requirements of an ocean mobile platform on efficient, compact and stable hydrogen production equipment are met.

The invention discloses a method for reducing nitro compounds through an electrochemical microreactor. According to the method, nitrobenzene or a derivative thereof is subjected to electrochemical catalysis in a multi-channel series electrolytic tank in a constant-current electrolysis mode to be reduced to generate aniline or a corresponding aniline derivative. According to the method disclosed by the invention, the Faraday efficiency is improved from 40% to more than 80% under the condition that the yield of the nitrobenzene is kept unchanged compared with that of the existing electrochemical reduction nitrobenzene, so that the fixed energy consumption is greatly reduced, and rapid, efficient, continuous and large-scale production of the nitrobenzene and the derivatives thereof is realized.

The utility model discloses a simple continuous flow microreactor device with replaceable packing. The simple continuous flow microreactor device comprises a liquid pipeline system, a gas pipeline system, a microreactor and a cooling and product collecting system, the micro-reactor is a filler type micro-reaction tube, the filler type micro-reaction tube comprises a tube body, the tube body is filled with a replaceable porous filler, and the porous filler has both a microporous structure and a mesoporous structure; filtering sieve plates for intercepting porous fillers with different sizes are respectively arranged at the upper end and the lower end of the pipe body, and are respectively connected with the material inlet and outlet joint through fixing pieces for stabilizing the fillers; a blade ring and a sealing ring are sequentially arranged between the fixing piece and the pipe body from top to bottom. The microreactor disclosed by the utility model is applied to preparation of amide compounds, and compared with a conventional microreactor, the microreactor disclosed by the utility model can obtain higher product yield.

The invention discloses a continuous hydrogenation device and process. The continuous hydrogenation device comprises a gas supply system, a liquid supply system, a heating system, a hydrogenation reactor, a gas-liquid mixing distributor, a cooling system, a gas-liquid separation system and a product collection system, the gas supply system and the liquid supply system are respectively connected with an inlet of the gas-liquid mixing distributor through pipelines, and an outlet of the gas-liquid mixing distributor is connected with an inlet of the reactor through a pipeline; a first spacer bush and a second spacer bush which are concentrically distributed are arranged in the reactor to form an S-shaped circulation channel, so that the retention time of materials is prolonged; meanwhile, various catalytic structures are provided, such as a micro-reaction channel with a catalyst coating on the inner wall, a filling type catalyst layer and a multi-stage micro-reactor, the contact area of raw materials and a catalyst is increased, the reaction conversion rate is increased, a crescent flow blocking column is arranged in a thick-section channel of the multi-stage micro-reactor, the gas-liquid mixing uniformity can be further enhanced, and the gas-liquid mixing efficiency is improved. Incomplete local reaction is avoided, and the product purity is improved.

The invention belongs to the field of chemical engineering, and relates to a process device and method for continuously synthesizing glycidyl (3-chloro-1, 2-propylene glycol and sodium hydroxide (hereinafter referred to as NaOH) as raw materials). The device comprises a raw material feeding pump, a heat exchanger, a micro-reactor, a delay tube reactor 1, a neutralization micro-reactor and a delay tube reactor 2 which are sequentially in fluid communication through pipelines, the heat exchangers are divided into two groups, one group is used for heat exchange of 3-chloro-1, 2-propylene glycol solution, and the other group is used for heat exchange of alkaline solution. According to the method, a 3-chloro-1, 2-propylene glycol solution and a sodium hydroxide solution (NaOH) are adopted as raw materials, glycidol is continuously prepared through a microchannel reactor, on the basis, an acid-base neutralization reaction can be carried out in situ according to needs to remove redundant alkali, redundant heat generated by the acid-base neutralization reaction is absorbed through a low-temperature material, and energy consumption is reduced; the product is analyzed by gas chromatography, and the generated glycidol does not have hydrolysates or auto-polymerization products, so that the product selectivity is higher.

The present invention relates to a multistage series microreactor and a fluid mixing method. The microreactor includes a base internally etched with a fluid passage, the base being provided with a fluid inlet and a fluid outlet which are communicated with the fluid passage, where the fluid passage includes a plurality of micro mixing tanks, a jet port is formed at an inlet of the micro mixing tank, adjacent micro mixing tanks are connected by jet port at a contraction section, and a splayed flow baffle plate and a flow splitting column which are arranged corresponding to the jet port are provided in the micro mixing tank, the flow splitting column being arranged below the splayed flow baffle plate. By means of a jet manner, a fluid to be mixed in the invention can be continuously split, compounded, stretched and crushed, thereby realizing rapid mixing and efficient, continuous reaction.

The invention discloses superfine copper powder and a preparation method and application thereof, and belongs to the technical field of copper powder.The preparation method of the superfine copper powder comprises the following steps that a micro-channel reactor is provided, and the micro-channel reactor comprises a micro-mixer and a micro-reactor which are connected with each other; a copper salt solution, a reducing agent solution and a sodium hydroxide solution are injected into a micro-channel reactor to be evenly mixed, a mixed solution is obtained and then enters the micro-channel reactor to be subjected to a reaction, discharging is conducted, and the superfine copper powder is obtained. The injection flow rate ratio of the sodium hydroxide solution to the copper salt solution to the reducing agent solution is (0.5-2): (0.8-1.2): (0.8-1.2). According to the method, the uniformity and the preparation efficiency of the superfine copper powder are remarkably improved, meanwhile, the reaction time is greatly shortened, the yield and the purity of the superfine copper powder are remarkably improved, continuous and efficient preparation of the superfine copper powder is achieved, and the method has wide application prospects.

The invention discloses a method and a system for improving heap leaching efficiency of metal ore by using micro-nano bubbles, which comprise the following steps: a) generating the micro-nano bubbles: installing a micro-reactor on a leachate conveying pipeline, introducing oxygen or air, and enabling the leachate to pass through the micro-reactor under a certain pressure to generate a leachate containing the micro-nano bubbles; b) conveying the gas-containing leachate: conveying the leachate containing the micro-nano bubbles to an ore dump leaching area, and enabling the leachate to be in full contact with the ore in the dump leaching process; and c) reinforcement of the dump leaching process: promoting leachate to permeate into fine gaps of ore particles by utilizing high permeability and high mass transfer characteristics of the micro-nano bubbles, enhancing the oxidation reaction and improving the leaching rate of metal. According to the method, the metal leaching rate is remarkably increased, the leaching time is shortened, the agent consumption is reduced, and remarkable economic benefits and environmental benefits are achieved.

The invention discloses a Pickering IL emulsion microreactor constructed on the basis of temperature-sensitive double-enzyme Janus spheres and application of the Pickering IL emulsion microreactor to enhanced catalysis of conversion of CO2 into formic acid. A Janus emulsion template method is combined with a photocuring technology to synthesize a nano-scale dual-functional temperature-sensitive Janus sphere, one half of the nano-scale dual-functional temperature-sensitive Janus sphere is a hydrophilic hydrocarbon polymer, the other half of the nano-scale dual-functional temperature-sensitive Janus sphere is a hydrophobic fluorocarbon polymer, and rapid inversion of a Pickering emulsion can be realized by utilizing temperature sensitivity. The method comprises the following steps: preparing a Janus particle hydrophilic / hydrophobic hemisphere, selectively immobilizing formate dehydrogenase FDH and carbonic anhydrase CA on the Janus particle hydrophilic / hydrophobic hemisphere to obtain a temperature-sensitive FDH-Janus-CA composite sphere, introducing a fluorine-functionalized ionic liquid to regulate and control the internal microenvironment of a microreactor, and constructing a Pickering IL emulsion microreactor. The CO2 absorption capacity is increased by 47 times compared with that of a pure water system, the formic acid yield reaches 27.5 mM and is higher than the maximum value 22.8 mM of current enzyme electrocatalysis, the storage and catalysis stability is good, and an efficient and sustainable scheme is provided for CO2 recycling.

The invention provides a preparation method and application of novel acrylic continuous pre-polymerized resin. The preparation method comprises the following steps: preheating an MMA solution containing azodiisobutyronitrile to 50-60 DEG C, and enabling the preheated MMA solution to flow into the microreactor main body; the pure MMA is preheated to 90-95 DEG C and then flows into the microreactor main body; and mixing the inflowing materials, controlling the reaction temperature to be 120-130 DEG C, the pressure to be 0.2-0.3 MPa and the retention time to be 5-15 minutes, and carrying out continuous polymerization reaction to prepare the PMMA prepolymer resin. According to the technology, accurate regulation and control of the molecular weight and distribution of the PMMA / MMA prepolymer are realized through a continuous process under high temperature and high pressure, and the goal can be achieved without depending on a chain transfer agent. The method is safe and controllable, the product of the method is perfectly compatible with a solid plane material curing system of'an initiator first and then an accelerant ', and the energy consumption and the safety risk are effectively reduced while the production efficiency and the productivity are remarkably improved.

The invention relates to a continuous preparation method of a supported catalyst and application of the supported catalyst in catalysis of furfural hydrocracking. The method comprises the following steps: adding Cu (NO3) 2.3 H2O, Ce (NO3) 3.6 H2O, Mg (NO3) 2.6 H2O and Al (NO3) 3.9 H2O into deionized water to form a solution A; naOH and Na2CO3 are taken and dissolved in deionized water, and a solution B is formed; then respectively introducing the solution A and the solution B into a feeding pump, then introducing into a membrane dispersion microreactor, and mixing to form a precipitate; and washing, drying, calcining and reducing to obtain the catalyst Cu-Ce / MgO-Al2O3. The catalyst prepared by the invention is used in a reaction for catalyzing furfural hydrocracking to prepare 1, 2-pentanediol, and shows excellent catalytic activity and stability, the conversion rate of furfural is as high as 99%, and the yield of 1, 2-pentanediol reaches 44%.

The present invention relates to the technical field of high polymer material synthesis, and discloses an anti-clogging microreactor for high viscosity silicone rubber synthesis, the anti-clogging microreactor comprises a microreactor chip, and the interior of the microreactor chip is provided with a tree-shaped bifurcated microchannel network based on fractal structure design; the invention relates to a continuous preparation method of an anti-clogging microreactor for synthesizing high-viscosity silicone rubber. The continuous preparation method comprises the following steps: S1, precisely metering a methyl cyclosiloxane monomer and a vinyl siloxane monomer, and then inputting the methyl cyclosiloxane monomer and the vinyl siloxane monomer into the microreactor; s2, carrying out a controllable ring-opening polymerization reaction in the microchannel; and S3, quickly terminating the reaction by injecting a terminating agent on line, and controlling the molecular weight and distribution of the polymer. Compared with the prior art, the method has the advantages that the problems that an existing microreactor is prone to blockage and difficult to operate stably for a long time when treating a high-viscosity siloxane polymerization system are solved, meanwhile, the method can achieve accurate control over product quality and continuity and intellectualization of the production process, the production efficiency is remarkably improved, and energy consumption is reduced.

The invention discloses a method for preparing nano aluminum oxide by a microreactor. The method comprises the following steps: S1, mixing aluminum salt and an alkaline solution through the microreactor, and standing and aging to obtain hydroxide precipitate; and S2, carrying out heat treatment on the hydroxide, and cooling, washing and drying after the treatment is finished, so as to obtain the nano aluminum oxide. The average particle size of the spherical aluminum oxide nano particles synthesized by the method is 16.8 nm, the average particle size of the spherical aluminum oxide nano particles synthesized by a traditional beaker method is 126.76 nm, and the average particle size of the spherical aluminum oxide nano particles synthesized by the method is reduced by 82.22% compared with the average particle size of the spherical aluminum oxide nano particles synthesized by the traditional beaker method, so that the invention provides an extensible nano material synthesis strategy.

The invention discloses an ultrasonic microreactor, system and method for preparing perovskite quantum dots. The ultrasonic microreactor comprises at least two feeding inlet ends, a discharging outlet end, a microchannel structure and an array microstructure. The micro-channel structure comprises a main channel and a plurality of branch channels, the main channel comprises a flow dividing section and a flow converging section, the flow dividing section is communicated with the feeding inlet end, the flow converging section is communicated with the discharging outlet end, and the inlet ends of the branch channels are arranged at intervals in the internal flowing direction of the flow dividing section; the outlet ends of the branch channels are arranged at intervals in the internal flowing direction of the confluence section, and the array microstructure comprises a plurality of three-dimensional protruding units arranged on the inner walls of the main channel and the branch channels in a protruding mode. Under the action of an ultrasonic field, the local shearing, turbulence and cavitation intensity is remarkably enhanced, so that rapid mixing and mass transfer enhancement of reactants under the micro-scale are realized, and continuous-flow and highly-controllable preparation of perovskite quantum dots is realized.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a process for preparing fipronil and an intermediate thereof. Toxic 1, 2-dichloroethane is comprehensively replaced by bio-based gamma-valerolactone, low-toxicity cyclopentyl methyl ether is matched, and N, N-dimethylformamide necessary for the process is recycled, so that consumption is greatly reduced; the continuous processes of amination, diazotization and the like are realized through a tubular reactor, a micro-reactor and a static mixer, and separation technologies such as pervaporation membrane and vacuum distillation are combined, so that the reaction time is shortened, the solvent recovery rate is increased, and the production is promoted to be continuously transformed to green. The supported FeCl3 / SiO2-NH2 catalyst disclosed by the invention can be repeatedly used, and byproducts and tail gas can be recycled and reused. In addition, diazonium salt residues are controlled to be smaller than or equal to 0.5% through near infrared spectroscopy, citric acid is subjected to stable oxidation reaction, a purification process is combined, it is ensured that the finished product is high in purity, excellent in yield and small in batch fluctuation, and efficiency and safety are both considered.

The application provides a heat pipe micro reactor steady-state multi-physical coupling method and system based on a fission response function, which integrates a fission response function physical program, a self-developed Unifoam finite element thermal program and a heat pipe program, realizes steady-state joint solution of three physical fields of nuclear neutronics, solid thermal engineering and heat pipe two-phase flow through a coupling iterative driving script, and obtains accurate power field and temperature field distribution of the heat pipe micro reactor under a steady-state working condition. The method pre-constructs a high-fidelity fission response function database through a Monte Carlo method, does not need to repeatedly perform a complex particle transport process during operation, and only needs to complete neutronics solution through matrix multiplication, so that the simulation accuracy and the calculation efficiency are effectively balanced.

The utility model relates to the technical field of chemical equipment, and discloses a microreactor for a high-viscosity reaction system, which comprises a feeding end cover (2), a discharging end cover (9), a primary reactor (4), a secondary reactor (8), an interstage connector I (6), an interstage connector II (18) and a crossover line (7), the feeding end cover (2) is arranged at the inlet end of the first-stage reactor (4), the first-stage reactor (4) and the second-stage reactor (8) are connected through the overline (7), the first-stage reactor (4) and the overline (7) are connected through the interstage connector I (6), and the second-stage reactor (8) and the overline (7) are connected through the interstage connector II (18); concave sealing pieces (3) are arranged on the inner walls of the interstage connector I (6) and the interstage connector II (18), and the concave corners are chamfered; and a discharge end cover (9) is arranged at the outlet end of the secondary reactor (8). The reactor weight is reduced, and the application is flexible and convenient.

The invention relates to a method for preparing a 4-chloro-3-nitroanisole compound, in particular to a method for preparing a 4-chloro-3-nitroanisole compound by using a microreactor, which comprises the following steps: carrying out a raw material diazotization reaction by using the microreactor, then carrying out a chlorination reaction in an intermittent tank reactor, and taking 2-methoxy-4-nitroaniline as a raw material to prepare the 4-chloro-3-nitroanisole compound. The 4-chloro-3-nitroanisole compound is prepared from sodium nitrite and cuprous chloride. According to the invention, diazotization of 4-chloro-3-nitroanisole is realized on the micro-reaction device, and the method has the advantages of simple process, continuous production, small reaction volume, short reaction time, small corrosion to equipment, high operation safety and the like. Meanwhile, by utilizing the characteristics of high-efficiency heat mass transfer capacity and easiness in direct amplification of the microchannel reactor, the yield is high and is 80-85%, the product quality is good, the energy consumption is low, and the method is a green, environment-friendly and high-efficiency method for preparing the 4-chloro-3-nitroanisole and is suitable for industrial application.

The invention discloses a reaction device for continuously producing dimethyl sulfoxide and a synthesis process, the reaction device comprises a rack, a reactor assembly, a heat exchange assembly, a pipeline assembly and a control assembly, the pipeline assembly comprises a feeding pipe and a discharging pipe, the feeding pipe and the discharging pipe are both communicated with the reactor assembly, and the heat exchange assembly is arranged on the rack; a material temperature transmitter and a first pressure transmitter are arranged on each of the feeding pipe and the discharging pipe; the heat exchange assembly comprises a heat exchange shell and a circulating cooling device, the reactor assembly is located in the heat exchange shell, the circulating cooling device is communicated with the first heat exchange space, and the heat exchange shell is provided with a first temperature transmitter; the reactor assembly comprises a reactor shell and a micro-reactor, the micro-reactor is arranged in the reactor shell, the circulating cooling device is communicated with the second heat exchange space, and the first temperature transmitter detects the temperature in the micro-reactor. According to the method, the existing dimethyl sulfoxide production process is simplified, the production cost is reduced, the product purity is high, byproducts are few, waste water and waste gas are less, and the requirement of green chemical development is met.

The present invention belongs to the technical field of green catalysis and biosynthesis, and particularly relates to a carbon-based microreactor, and a preparation method and application thereof. According to the present invention, a carbon-based microchannel monolithic column is prepared by utilizing a graded pore structure of regular channels of natural wood in combination with an inorganic salt supporting framework, temperature programmed accurate carbonization and other methods, and then, the multiple advantages of the carbon monolithic column, the microreactor, and immobilized enzyme / chemical catalyst are fully played from the view of key technologies such as carbon-based microreactor construction, operation control, etc. The microreactor has the advantages of low cost, easy access, simple preparation, high flux, high mass and heat transfer efficiency, environmental friendliness, easy mass production, continuity, automation, suitability for homogeneous and heterogeneous reactions, high product quality, and long-term stable operation.

The present application relates to the field of micro-reactor, and discloses a double-layer composite micro-reaction channel plate with three-dimensional stepped channels and a micro-channel reactor.The double-layer composite micro-reaction channel plate comprises an upper channel plate and a lower channel plate which are superimposed;the top surface of the upper channel plate is provided with heat exchange channels A, and the bottom surface is provided with a first fluid inlet;the first fluid pre-heat exchange channel;the second fluid inlet;the second fluid pre-heat exchange channel;the mixing channel;and the mixed fluid outlet.A plurality of stepped cavities A are staggered along the flow direction at the bottom of the mixing channel.The bottom surface of the lower channel plate is provided with heat exchange channels B, and the top surface is provided with stepped cavities B which correspond to the positions and sizes of the stepped cavities A one by one.The double-layer composite micro-reaction channel plate of the present application is provided with special three-dimensional stepped channels, and the mixed fluid will produce fluctuation when passing through the structure, which can greatly enhance the disturbance of the fluid under the premise of not increasing the fluid resistance, so that the advection becomes turbulent flow, and the mixing effect is significantly enhanced.

The invention relates to a film microreactor for multiple nucleic acid detection, a detection system and a detection method, the film microreactor comprises a substrate, a first flexible film and a second flexible film, functional chambers such as a nucleic acid amplification chamber, a CRISPR reagent storage chamber, a probe hybridization chamber, a test strip chamber and the like are formed in the film microreactor, and adjacent chambers are isolated through destructible pseudo soldering seals. The detection system realizes movement, extrusion and heating control of the microreactor through the first driving assembly and the second driving assembly. The detection method comprises the steps of nucleic acid amplification, CRISPR (clustered regularly interspaced short palindromic repeats) cutting, probe hybridization, lateral chromatography and the like, and multiple nucleic acid detection can be automatically completed in a totally closed environment. The method does not need a complex etching process, and is low in cost; the detection system does not need expensive optical components, and multiple detection is realized through the test strip; the whole process is automatically carried out in a closed chamber, manual operation and aerosol pollution are avoided, the detection sensitivity is high, and the method is suitable for multiple nucleic acid detection of various scenes such as clinical samples.