The invention relates to a material of a nanometer silica hollow sphere and a synthesizing method thereof, belonging to the technical field of nanometer material. Wherein, a novel material of a nanometer silica hollow sphere is synthesized by the sol-gel method under the guidance of micelle, and is characterized in that the size is super small, particles are distributed evenly (the deviation of the particle size is less than 3 percent), the pore diameter is 5 to 20 nm, the wall thickness is 5 to 20 nm, and the particle size is adjustable. The synthesizing method comprises procedures of self-assembling, monodisperse controlling, dialyzing, drying and removing a template agent, etc. of the silica hollow sphere under the guidance of the micelle. The material has the advantages that the reaction conditions are mild, the operation is simple and easy, and the ultimate material is cheap and easily available. The physicochemical properties of the particle size and the pore diameter, etc. of the material can be modified by changing conditions of the raw material ratio, added expansion reagents, reaction temperatures and reaction time, etc. The nanometer silica hollow sphere has wide application prospect in the field of adsorption, drug sustained release, the catalyst carrier, the microreactor, and cell intervention targeted diagnosis and treatment.