286results about How to "Reaction raw materials are cheap and easy to obtain" patented technology

A process for synthesizing methyl aminoformate includes the catalytic reaction between methanol, urea and catalyst at 120-200 deg.C, under 0.1-3 MPa for 0.5-20 hr and condensing and recovering ammonia gas. Its advantages are low cost and high selectivity to product.

The invention relates to a method for synthesizing a carbyne nano-material from calcium carbide and polyhalohydrocarbon as raw materials through ball-milling and belongs to the field of preparation of novel carbon nano-materials. The method is characterized by comprising the steps: adding the calcium carbide and the polyhalohydrocarbon, which serve as the raw materials for preparing the carbon material, into a ball milling tank in one time or in a staged manner according to a certain ratio, and carrying out a ball-milling reaction for a certain time; and after the reaction ends, subjecting the product to acid washing, and performing water washing and drying, thereby obtaining the carbyne nano-material. According to the method, the reaction raw materials are cheap and readily available, the reaction conditions are mild, and the reaction equipment and process are simple. The produced carbon material is uniform in texture and excellent in physico-chemical properties and has a broad application prospect in the fields of energy, catalysis, environmental protection and the like.

The invention relates to a tryptanthrin copper complex with antitumor activity and a synthetic method thereof; the tryptanthrin copper complex with antitumor activity has a structure as shown below; the tryptanthrin copper complex has significant inhibitory effect on ovarian cancer cell line Skov3, has potential medicinal value, is expected to serve as a metal antitumor drug and belongs to the technical field of medicine.

The invention provides a preparation method of a 2,4,5-trisubstituted imidazole compound. The 2,4,5-trisubstituted imidazole compound is synthesized through a reaction of alpha-nitro epoxide with an amidine compound and an alkali at room temperature via a one-pot process. The synthetic method has the characteristics of mild conditions, high yield, and cheap and easily available raw materials, and is a simple and feasible method for efficiently synthesizing the 2,4,5-trisubstituted imidazole compound. The preparation method also has the advantages of reasonable design, easily available raw materials, easy and convenient operation, mild conditions and high yield.

The invention relates to an alpha-diimine nickel metal organic compound and a preparation method thereof. The preparation method comprises the following steps: adding NiBr2 (DME) and alpha-diimine into a dichloromethane solution for reaction under the protection of an inert atmosphere, reducing an obtained product in a diethyl ether or n-hexane solution by using metallic sodium, and then reacting with 1,5-cyclooctadiene to obtain a mononuclear nickel metal organic compound of alpha-diimine. The preparation method provided by the invention is simple, is high in product yield and good in purity and can be used as an olefin polymerization catalyst.

The invention discloses a method for preparing 3-aminopyrrolidine hydrochloride by using a one-pot method. Under an ice-water bathing condition, pyrrole is dissolved in acetonitrile, a catalyst di(triphenyl phosphine) cupric nitrate is added at the same time, nitric acid is added dropwise to conduct a reaction to generate reaction liquid containing 3-nitropyrrole, the reaction liquid is subjectedto extraction by water and ethyl acetate, and an organic phase is obtained after separation is conducted; the obtained organic phase is subjected to reduction by pumping in hydrogen gas under the palladium catalysis condition, and a crude product of 3-aminopyrrolidine is obtained; and a solvent ethyl acetate is added into the crude product of 3-aminopyrrolidine, HCl gas is pumped in to conduct a reaction, and 3-aminopyrrolidine hydrochloride is obtained. The experiment route of the method is simple and short, the raw materials are cheap and easy to get, and the reaction condition is mild.

The invention discloses a preparation method of a 3-selenocoumarin compound, which comprises the following steps: in a DCM solvent, synthesizing to obtain the 3-selenocoumarin compound at room temperature by using PIFA as an oxidant and using a coumarin compound and a selenide compound as substrates. According to the method, the reaction raw materials are cheap and easy to obtain, the preparationmethod is simple, PIFA is used as an oxidizing agent, the reaction cost is low, the reaction time is short, the yield is high, the operation is simple, and the method is suitable for synthesizing different types of 3-selenocoumarin compounds. The method disclosed by the invention can be used for synthesizing a series of 3-selenocoumarin compounds, and the synthesized product can be used as an intermediate compound for further constructing a complex active compound; meanwhile, the compound has great drug activity potential.

The invention relates to a polysubstituted benzothiophene thiazole and a derivative and a synthetic method thereof. The method comprises the steps that ketoxime ester compounds, formaldehyde compoundsand powdered sulfur are converted into 2-polysubstituted benzothiophene-[3,2-d] thiazole and the derivative in the air atmosphere under Cu catalysis for the first time, and the obtained product is stable in molecular structure and good in chemical property. According to the synthesis method, reaction raw materials are cheap and easy to obtain, no preprocessing is needed, and the atom economy of the reaction is high; only cheap copper catalyst needs to be adopted in the reaction, environment contaminations are reduced, raw materials are saved, and the reaction cost is lowered; the whole reaction system is simple, reaction conditions are mild, a small amount of reaction equipment is needed, the experiment operation is easy and convenient, and the adopted materials are wide in source.

The invention provides a method for synthesizing aniline by directly oxidizing and aminating benzene by one step. The method is characterized by taking benzene as a raw material, ammonia water as an aminating agent, hydrogen peroxide as an oxidizing agent, water as a solvent and CuO / SiO2 which is obtained after silicon dioxide with microporous, mesoporous and macroporous structures is modified with metallic copper as a catalyst. The method has the characteristics that the yield of aniline is higher; the reaction conditions are mild; the catalyst preparation process is simple; the raw material is cheap and accessible; and therefore, the method is environment-friendly and has the advantages of low cost, high yield, simplicity and practicability.

A process for synthesizing (S)-isopropyl-(2-pipeeridine) phenyl-methylamine nicludes reaction between trimethylallyl boronane and tartaric acid derivative, asymmetric allylation reaction on o-chlorobenzaldehyde, halogenation, reacting on azo compound, catalytic reduction reaction and coupling with piperidine.

The invention belongs to the technical field of synthetic chemistry and relates to a dinuclear half-sandwich iridium complex containing bisimine ligand and a preparation method and application thereof. Pentamethylcyclopentadienyl iridium chloride dimer [(C5Me5)IrCl2]2 is used as a raw material subjected to reaction with pyrrole ring-containing bisimine ligand under alkaline conditions to prepare the finished N,N-coordinated dinuclear half-sandwich iridium complex. The synthetic process herein is simple and green and has good selectivity and high yield; the dinuclear half-sandwich iridium complex herein has stable physio-chemical properties and thermal stability and the like and shows efficient catalytic activity in the reaction where halogenated hydrocarbons are oxidized into correspondingaldehydes.

The invention provides a preparation method for a 1,4,5-trisubstituted-2-amino imidazole compound. The 1,4,5-trisubstituted-2-amino imidazole compound is generated by reaction of a 2,3-disubstituted-2-nitro oxirane compound and an amine compound which are easily subjected to chemosynthesis and cyanamide at the room temperature. According to the preparation method provided by the invention, the design is reasonable, the raw materials are easily accessible, no auxiliary additives needs to be added, the operation is simple and convenient, and the general formula of the 1,4,5-trisubstituted-2-amino imidazole compound is shown in the description.

The invention relates to technology for synthesizing an intermediate in the medicinal and chemical industry, in particular to a catalyst for catalytic synthesis of N-methylpyrrolidine and a synthesis method thereof. The catalyst consists of a carrier and a catalytic activity component, wherein the carrier is a gamma-Al2O3 or HZSM series molecular sieve; the catalytic activity component is a simple substance of metal M or an oxide thereof; the catalytic activity component accounts for 0.5 to 20 percent of the total weight of the catalyst; and the granular size of the catalyst is 4 to 20 meshes. The catalyst is prepared by a kneading and extruding method or a dipping method. The catalyst has the advantages of simple preparation, low price of raw materials and easy purchase; and when used the catalytic synthesis of N-methylpyrrolidine, the catalyst has the advantages of mild catalytic reaction condition, low three-wastes and no pollution, wherein the conversion rate of tetrahydrofuran is substantially kept over 80 percent and the yield of the N-methylpyrrolidine is substantially kept over 60 percent.

The invention belongs to the fields of materials and catalysis and relates to a preparation method of surface-modified g-C3N4. The preparation method comprises the following steps: firstly, creatively carrying out direct high-temperature reaction on sodium halide, potassium halide or a mixture of sodium halide and potassium halide and g-C3N4; introducing water in the reaction process and enabling the modified g-C3N4 to contain hydroxide radicals; modifying corresponding metal ions on the surface of the modified g-C3N4. The method has the characteristics of simple operation, easiness in realization, low-priced and easily-obtained reaction raw materials, environment friendliness, high yield of the modified g-C3N4 and the like; in addition, abundant hydroxide radicals and porous structures on the surface of the modified g-C3N4 surface can generate abundant hydroxyl free radicals under visible light; the characteristics lay a foundation for actual application of the modified g-C3N4 in the field of photocatalysis.

The invention discloses a new method of preparing alkyl cyanophenyl. The new method comprises the following steps: alkylbenzene is used as raw material, is processed through chloromethylation to obtain alkyl benzyl chloride first, and then is processed through ammoxidation to prepare the alkyl cyanophenyl. In the new method, the reaction-path is short, the reaction temperature is low, the yield rate is high, and the selectivity is high. The invention also discloses a high efficiency catalyst used for preparing the alkyl cyanophenyl through the ammonia oxidation process. The catalyst is silica gel or a vanadium chromium five-component system loaded by aluminum oxide, wherein, the vanadium chromium five-component system is VaCrbCcDdEeOx; the catalyst can effectively catalyze the alkyl benzyl chloride to act ammoxidation to obtain the alkyl cyanophenyl; the high efficiency catalyst has the advantages of high activity, high product yield rate, good selectivity, high product purity, long service life, simple technology, etc.

The invention provides a preparation method of a lithium difluorobisoxalate phosphate solution, and the method comprises the following steps: 1) reacting N-hydroxysuccinimide and oxalyl chloride in anon-aqueous solvent to obtain a di (N-succinimido) oxalic acid solution; and 2) adding lithium hexafluorophosphate into the di (N-succinimido) oxalic acid solution, and reacting to obtain the lithiumdifluorobisoxalate phosphate solution. According to the preparation method, the obtained solution can be directly used for lithium salt electrolyte materials of lithium ion batteries without further purification, and the method has the advantages of cheap and easily available reaction raw materials, simple operation, environmental friendliness of byproducts, and suitability for industrial production.

The invention discloses a synthetic method for aminomethylbenzoic acid. The synthetic method specifically comprises the following steps: adding 4-halomethyl alkyl benzoate and triethylamine, dropwiseadding ethanol-water solution in which 2-amino-5-methyl-1,3,4-thiadiazole is dissolved while stirring, after a reaction is completed, evaporating solution until a lot of solids are separated out, cooling, filtering, and drying to obtain 4-aminomethyl alkyl benzoate; adding the 4-aminomethyl alkyl benzoate to acid solution, reacting by stirring, cooling, adding water, and dropwise adding alkali until the solution is alkaline, and a lot of the solids are separated out, filtering, washing, and drying to obtain the aminomethylbenzoic acid. The synthetic method is moderate in reaction conditions, less in side reactions, high in yield, low in cost, short in reaction and post-processing time, low in energy consumption, high in production efficiency, small in environmental pollution, and simple in'three wastes' treatment, and suitable for the industrial production. -CN with strong toxicity and an organic solvent with strong pollution are not used, and reaction raw materials are cheap in priceand easy to obtain.

The invention discloses a preparation method of seleno-flavonoid compounds. The preparation method comprises the step of preparing the seleno-flavonoid compounds through direct compounding of hydrocarbon functional groups in substrates (chromone compounds and diselenide compounds) in a DMF solvent in the presence of an accelerant NIS / TBHP. The preparation method has the beneficial effects that thereaction raw materials are cheap and easily available, and the preparation method is simple; the synthetic method of the use amount of diselenide is 0.5, and meanwhile, the cheap and easily availablenon-metal reagent NIS / TBHP is taken as the reaction accelerant, so that the method is an environment-friendly and atom-economic synthetic method. The reaction is carried out at 70 DEG C, the reactiontime is short, the yield is high, and the operation is simple. The method can be used for synthesizing a series of the seleno-flavonoid compounds, and a synthesized product can be taken as an intermediate product and can be used for further constructing complex active compounds; and meanwhile, the compounds have great drug activity potential.

The invention discloses a special catalyst for preparing p-chlorobenzonitrile by an ammonoxidation process. Organosilicone modified silica gel serves as a carrier of the special catalyst, a main catalyst comprises vanadium and phosphorus, a cocatalyst comprises at least one of an ingredient G, an ingredient D and an ingredient E, and an active ingredient of the special catalyst is represented as VPbGcDdEeOx; and the G is molybdenum, chromium, titanium, nickel or bismuth, the D is boron, manganese, ferrum, cobalt, copper, zinc or tin, and the E is potassium, lithium, sodium, cesium, magnesium or calcium. The invention further discloses a preparation method for the catalyst and use of the catalyst. According to the special catalyst, the preparation method and the use, electron donating groups on organosilicone and inorganic elements are subjected to an Lewis acid alkali reaction, and thus, actions of inorganic oxides and the carrier are strengthened; and meanwhile, the inorganic oxides can be more uniformly dispersed, catalyst ingredients are low in loss, the catalytic activity is high, the selectivity is good, and the service life of a commercial catalyst is prolonged to 2 years ormore from 1 year. The catalyst is simple in preparation method, low in cost and good in thermal stability and mechanical strength and can be applied to fixed-bed and fluidized-bed reactors.

The invention relates to a 4, 4-disubstituted-4, 5-dihydro-1H-imidazole-5-one and derivatives thereof as well as a synthesis method thereof. The synthesis method adopts the technical scheme that amidine compounds and ketones are converted into imidazolone and derivatives thereof in the absence of catalysts just under the action of alkali by using air or oxygen as an oxidant and pyridine, quinoline, triethylamine, NMP, DMA, DMSO, 1, 4-dioxane, toluene and the like as an organic solvent. The synthesis method overcomes the difficulties of the existing method for synthesizing imidazolone compounds of complicated synthesis steps, multi-step synthesis processes as well as the use of metal catalysts, metal oxidants or peroxides of chemical equivalent; and 4, 4-disubstituted-4, 5-dihydro-1H-imidazole-5-one and the derivatives thereof are suitably used as multifunctional materials, and are important raw materials especially for producing the medicine Avapro for treating high blood pressure.

The invention relates to polysubstituted indole bithiophene and a derivative and a synthesis method thereof. The technical scheme which is adopted for the first time includes that indole compounds, alkene, alkyne and ketone compounds and sulfur powder are converted into 2-substituted thieno[2,3-b]indole and the derivative in an air atmosphere under catalysis of Bronsted acid, and a product and additional products stable in molecular structure and excellent in chemical property are obtained, raw reaction materials are cheap and easy to acquire without pretreatment, and high reaction atom economy is achieved; the reaction only requires utilization of cheap Bronsted acid, so that environment pollution abatement, raw material saving and reaction cost reduction are realized; the whole reaction system is simple, reaction conditions are mild, a small quantity of reaction devices are adopted, and simplicity and convenience in experiment operation and extensive material sources are realized.

The invention discloses a preparation method of a 2-trifluoromethyl substituted imidazole compound. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, an additive, trifluoroethyl imine acyl chloride, propargylamine and diaryliodonium salt into an organic solvent, carrying out a reaction at 30 DEG C for 18-20 h, and after the reaction is completed, carrying out post-treatment to obtain the 2-trifluoromethyl substituted imidazole compound. The preparation method has the advantages of simple operation, cheap and easily available initial raw materials, high reaction efficiency, good substrate compatibility, realization of synthesis of diversified substituted trifluoromethyl-containing imidazole compounds through substratedesign, convenience in operation, and widening of the practicality of the method.

The invention provides a preparation method of multifunctional group-substituted imidazole derivatives including derivatives of 2,4,5-trisubstituted imidazole and 2-amino-4,5-disubstituted imidazole, and the derivatives are generated by alkenyl nitrine derivatives which are easy to be synthesized chemically and leaving group-containing imine compounds under a heating condition. The preparation method provided by the invention is reasonable in design, and easily available in raw materials, needs no addition of any auxiliary additive, and is simple and convenient in operation. The polysubstituted imidazole derivatives are as shown in general formula I in the description.

The invention belongs to the technical field of organic synthesis and particularly relates to a synthesis method of N-methyl-2-fluoroaniline. The synthesis method comprises the following steps: step one, mixing 2-fluoroaniline with concentrated hydrochloric acid, adding a sodium nitrite solution and carrying out thermal reaction to obtain 2-fluoroaniline diazonium salt; step two, adding the 2-fluoroaniline diazonium salt into a methylamine aqueous solution, and carrying out thermal reaction and post treatment to obtain the N-methyl-2-fluoroaniline. According to the method, the N-methyl-2-fluoroaniline with high yield and high selectivity can be obtained by taking the 2-fluoroaniline as a raw material, carrying out diazotization reaction on the 2-fluoroaniline and then carrying out high temperature reaction on the methylamine aqueous solution and a reactant; reaction raw materials are cheap and easily obtained; the process is reasonable, advanced and feasible; the obtained N-methyl-2-fluoroaniline has the advantages of high purity, good quality and capability of being industrially produced on a large scale.

The invention discloses a preparation method of a 1,3,5-trisubstituted 1,2,4-triazole compound. The preparation method comprises the following steps that simple substance iodine, tert-butyl hydroperoxide (a 70% aqueous solution), hydrazone and fatty amine are added into organic solvent, the materials are heated to the temperature of 80 DEG C-100 DEG C for a reaction, and after the reaction is complete, aftertreatment is performed to obtain the 1,3,5-trisubstituted 1,2,4-triazole compound. The preparation method has the advantages that the steps are simple, the raw materials are cheap and easy to obtain, and the reaction does not need to be performed under water-free and oxygen-free conditions; in addition, heavy metal does not need to be used as a catalyst, diversely substituted 1,2,4-triazole compounds with different substituted positions can be synthesized through the design, and the applicability of the method is widened while operation is convenient.

The invention discloses a special catalyst for preparing o-chlorobenzonitrile by an ammoxidation method. A carrier of the special catalyst is organic silicon modified silica gel, a main catalyst comprises three components of V, P and rare earth metal Re, and a cocatalyst comprises at least one of three components of D, E and G; the active component of the catalyst is represented by VPRe<c>D<d>E<e>G<g>O<x>; the rare earth metal Re is lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium or scandium; D is titanium, chromium, molybdenum, manganese, antimony or bismuth; E is boron, iron, cobalt, nickel, zinc or tin; and G is lithium, sodium, potassium, caesium, magnesium or calcium. The invention also discloses a preparation method and application of the catalyst. The rare earth metal is used for adjusting the acidity and alkalinity, the oxidation-reduction capacity and the coordinationcapacity with reactants of the catalyst, and improving the activity of the catalyst and the selectivity of products, and the service life of the industrial catalyst is prolonged by utilizing organic silicon to reinforce the action of an inorganic oxide and the carrier. The catalyst is simple in preparation method and good in thermal stability and mechanical strength.

The invention relates to a multi-substituted 6-aryl benzo [a] carbazole, derivatives thereof, a synthesizing method of the multi-substituted 6-aryl benzo [a] carbazole. According to the synthesizing method of the multi-substituted 6-aryl benzo [a] carbazole, for the first time under catalysis of iodine compounds and in an air atmosphere, 2-aryl indole compounds, aromatic alkyne compounds or aromatic ketone compounds are converted into the multi-substituted 6-aryl benzo [a] carbazole and the derivatives thereof to prepare products and by-products, which are stable in molecular structure and excellent in chemical properties; reaction materials are low in price and easy to acquire and save pretreatment; reaction is high in atom economy and simple in operation and can be promoted through low-price iodine compounds, thereby being low in environmental pollution and reaction costs; the entire reaction system is simple, mild in reaction conditions, few in reaction equipment, simple and safe and experimental operation and rich and wide in material resources.

The invention provides a preparation method of spherical magnetic ferrite (zinc ferrite, magnesium ferrite and manganese ferrite) by taking ethanol amine as a precipitator in a solvothermal method. The preparation method is characterized by comprising the steps of: taking ferric trichloride and an ethylene glycol solution of chloride as a reaction solution as well as the ethanol amine as a precipitator; stirring at the room temperature and evenly mixing to form a liquid phase reaction solution; transferring the liquid phase reaction solution into a reaction kettle, and carrying out hydrothermal reaction at 180-250 DEG C; and after the reaction, separating, washing and drying the product to obtain the corresponding ferrite powder. The method has the characteristics of being low in price of raw materials, simple in technology, convenient in operation, controllable in morphology, etc.