285results about How to "Reaction raw materials are cheap and easy to obtain" patented technology

A process for synthesizing methyl aminoformate includes the catalytic reaction between methanol, urea and catalyst at 120-200 deg.C, under 0.1-3 MPa for 0.5-20 hr and condensing and recovering ammonia gas. Its advantages are low cost and high selectivity to product.

The invention relates to a method for synthesizing a carbyne nano-material from calcium carbide and polyhalohydrocarbon as raw materials through ball-milling and belongs to the field of preparation of novel carbon nano-materials. The method is characterized by comprising the steps: adding the calcium carbide and the polyhalohydrocarbon, which serve as the raw materials for preparing the carbon material, into a ball milling tank in one time or in a staged manner according to a certain ratio, and carrying out a ball-milling reaction for a certain time; and after the reaction ends, subjecting the product to acid washing, and performing water washing and drying, thereby obtaining the carbyne nano-material. According to the method, the reaction raw materials are cheap and readily available, the reaction conditions are mild, and the reaction equipment and process are simple. The produced carbon material is uniform in texture and excellent in physico-chemical properties and has a broad application prospect in the fields of energy, catalysis, environmental protection and the like.

The invention relates to a tryptanthrin copper complex with antitumor activity and a synthetic method thereof; the tryptanthrin copper complex with antitumor activity has a structure as shown below; the tryptanthrin copper complex has significant inhibitory effect on ovarian cancer cell line Skov3, has potential medicinal value, is expected to serve as a metal antitumor drug and belongs to the technical field of medicine.

The invention provides a preparation method of a 2,4,5-trisubstituted imidazole compound. The 2,4,5-trisubstituted imidazole compound is synthesized through a reaction of alpha-nitro epoxide with an amidine compound and an alkali at room temperature via a one-pot process. The synthetic method has the characteristics of mild conditions, high yield, and cheap and easily available raw materials, and is a simple and feasible method for efficiently synthesizing the 2,4,5-trisubstituted imidazole compound. The preparation method also has the advantages of reasonable design, easily available raw materials, easy and convenient operation, mild conditions and high yield.

The invention relates to an alpha-diimine nickel metal organic compound and a preparation method thereof. The preparation method comprises the following steps: adding NiBr2 (DME) and alpha-diimine into a dichloromethane solution for reaction under the protection of an inert atmosphere, reducing an obtained product in a diethyl ether or n-hexane solution by using metallic sodium, and then reacting with 1,5-cyclooctadiene to obtain a mononuclear nickel metal organic compound of alpha-diimine. The preparation method provided by the invention is simple, is high in product yield and good in purity and can be used as an olefin polymerization catalyst.

The invention discloses a preparation method of a 3-selenocoumarin compound, which comprises the following steps: in a DCM solvent, synthesizing to obtain the 3-selenocoumarin compound at room temperature by using PIFA as an oxidant and using a coumarin compound and a selenide compound as substrates. According to the method, the reaction raw materials are cheap and easy to obtain, the preparationmethod is simple, PIFA is used as an oxidizing agent, the reaction cost is low, the reaction time is short, the yield is high, the operation is simple, and the method is suitable for synthesizing different types of 3-selenocoumarin compounds. The method disclosed by the invention can be used for synthesizing a series of 3-selenocoumarin compounds, and the synthesized product can be used as an intermediate compound for further constructing a complex active compound; meanwhile, the compound has great drug activity potential.

The invention relates to a polysubstituted benzothiophene thiazole and a derivative and a synthetic method thereof. The method comprises the steps that ketoxime ester compounds, formaldehyde compoundsand powdered sulfur are converted into 2-polysubstituted benzothiophene-[3,2-d] thiazole and the derivative in the air atmosphere under Cu catalysis for the first time, and the obtained product is stable in molecular structure and good in chemical property. According to the synthesis method, reaction raw materials are cheap and easy to obtain, no preprocessing is needed, and the atom economy of the reaction is high; only cheap copper catalyst needs to be adopted in the reaction, environment contaminations are reduced, raw materials are saved, and the reaction cost is lowered; the whole reaction system is simple, reaction conditions are mild, a small amount of reaction equipment is needed, the experiment operation is easy and convenient, and the adopted materials are wide in source.

The invention provides a method for synthesizing aniline by directly oxidizing and aminating benzene by one step. The method is characterized by taking benzene as a raw material, ammonia water as an aminating agent, hydrogen peroxide as an oxidizing agent, water as a solvent and CuO/SiO2 which is obtained after silicon dioxide with microporous, mesoporous and macroporous structures is modified with metallic copper as a catalyst. The method has the characteristics that the yield of aniline is higher; the reaction conditions are mild; the catalyst preparation process is simple; the raw material is cheap and accessible; and therefore, the method is environment-friendly and has the advantages of low cost, high yield, simplicity and practicability.

A process for synthesizing (S)-isopropyl-(2-pipeeridine) phenyl-methylamine nicludes reaction between trimethylallyl boronane and tartaric acid derivative, asymmetric allylation reaction on o-chlorobenzaldehyde, halogenation, reacting on azo compound, catalytic reduction reaction and coupling with piperidine.

The invention belongs to the technical field of synthetic chemistry and relates to a dinuclear half-sandwich iridium complex containing bisimine ligand and a preparation method and application thereof. Pentamethylcyclopentadienyl iridium chloride dimer [(C5Me5)IrCl2]2 is used as a raw material subjected to reaction with pyrrole ring-containing bisimine ligand under alkaline conditions to prepare the finished N,N-coordinated dinuclear half-sandwich iridium complex. The synthetic process herein is simple and green and has good selectivity and high yield; the dinuclear half-sandwich iridium complex herein has stable physio-chemical properties and thermal stability and the like and shows efficient catalytic activity in the reaction where halogenated hydrocarbons are oxidized into correspondingaldehydes.

The invention provides a preparation method of a lithium difluorobisoxalate phosphate solution, and the method comprises the following steps: 1) reacting N-hydroxysuccinimide and oxalyl chloride in anon-aqueous solvent to obtain a di (N-succinimido) oxalic acid solution; and 2) adding lithium hexafluorophosphate into the di (N-succinimido) oxalic acid solution, and reacting to obtain the lithiumdifluorobisoxalate phosphate solution. According to the preparation method, the obtained solution can be directly used for lithium salt electrolyte materials of lithium ion batteries without further purification, and the method has the advantages of cheap and easily available reaction raw materials, simple operation, environmental friendliness of byproducts, and suitability for industrial production.

The invention discloses a synthetic method for aminomethylbenzoic acid. The synthetic method specifically comprises the following steps: adding 4-halomethyl alkyl benzoate and triethylamine, dropwiseadding ethanol-water solution in which 2-amino-5-methyl-1,3,4-thiadiazole is dissolved while stirring, after a reaction is completed, evaporating solution until a lot of solids are separated out, cooling, filtering, and drying to obtain 4-aminomethyl alkyl benzoate; adding the 4-aminomethyl alkyl benzoate to acid solution, reacting by stirring, cooling, adding water, and dropwise adding alkali until the solution is alkaline, and a lot of the solids are separated out, filtering, washing, and drying to obtain the aminomethylbenzoic acid. The synthetic method is moderate in reaction conditions, less in side reactions, high in yield, low in cost, short in reaction and post-processing time, low in energy consumption, high in production efficiency, small in environmental pollution, and simple in'three wastes' treatment, and suitable for the industrial production. -CN with strong toxicity and an organic solvent with strong pollution are not used, and reaction raw materials are cheap in priceand easy to obtain.

The invention discloses a preparation method of seleno-flavonoid compounds. The preparation method comprises the step of preparing the seleno-flavonoid compounds through direct compounding of hydrocarbon functional groups in substrates (chromone compounds and diselenide compounds) in a DMF solvent in the presence of an accelerant NIS/TBHP. The preparation method has the beneficial effects that thereaction raw materials are cheap and easily available, and the preparation method is simple; the synthetic method of the use amount of diselenide is 0.5, and meanwhile, the cheap and easily availablenon-metal reagent NIS/TBHP is taken as the reaction accelerant, so that the method is an environment-friendly and atom-economic synthetic method. The reaction is carried out at 70 DEG C, the reactiontime is short, the yield is high, and the operation is simple. The method can be used for synthesizing a series of the seleno-flavonoid compounds, and a synthesized product can be taken as an intermediate product and can be used for further constructing complex active compounds; and meanwhile, the compounds have great drug activity potential.

The invention discloses a special catalyst for preparing p-chlorobenzonitrile by an ammonoxidation process. Organosilicone modified silica gel serves as a carrier of the special catalyst, a main catalyst comprises vanadium and phosphorus, a cocatalyst comprises at least one of an ingredient G, an ingredient D and an ingredient E, and an active ingredient of the special catalyst is represented as VPbGcDdEeOx; and the G is molybdenum, chromium, titanium, nickel or bismuth, the D is boron, manganese, ferrum, cobalt, copper, zinc or tin, and the E is potassium, lithium, sodium, cesium, magnesium or calcium. The invention further discloses a preparation method for the catalyst and use of the catalyst. According to the special catalyst, the preparation method and the use, electron donating groups on organosilicone and inorganic elements are subjected to an Lewis acid alkali reaction, and thus, actions of inorganic oxides and the carrier are strengthened; and meanwhile, the inorganic oxides can be more uniformly dispersed, catalyst ingredients are low in loss, the catalytic activity is high, the selectivity is good, and the service life of a commercial catalyst is prolonged to 2 years ormore from 1 year. The catalyst is simple in preparation method, low in cost and good in thermal stability and mechanical strength and can be applied to fixed-bed and fluidized-bed reactors.

The invention relates to a 4, 4-disubstituted-4, 5-dihydro-1H-imidazole-5-one and derivatives thereof as well as a synthesis method thereof. The synthesis method adopts the technical scheme that amidine compounds and ketones are converted into imidazolone and derivatives thereof in the absence of catalysts just under the action of alkali by using air or oxygen as an oxidant and pyridine, quinoline, triethylamine, NMP, DMA, DMSO, 1, 4-dioxane, toluene and the like as an organic solvent. The synthesis method overcomes the difficulties of the existing method for synthesizing imidazolone compounds of complicated synthesis steps, multi-step synthesis processes as well as the use of metal catalysts, metal oxidants or peroxides of chemical equivalent; and 4, 4-disubstituted-4, 5-dihydro-1H-imidazole-5-one and the derivatives thereof are suitably used as multifunctional materials, and are important raw materials especially for producing the medicine Avapro for treating high blood pressure.

The invention discloses a preparation method of a 2-trifluoromethyl substituted imidazole compound. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, an additive, trifluoroethyl imine acyl chloride, propargylamine and diaryliodonium salt into an organic solvent, carrying out a reaction at 30 DEG C for 18-20 h, and after the reaction is completed, carrying out post-treatment to obtain the 2-trifluoromethyl substituted imidazole compound. The preparation method has the advantages of simple operation, cheap and easily available initial raw materials, high reaction efficiency, good substrate compatibility, realization of synthesis of diversified substituted trifluoromethyl-containing imidazole compounds through substratedesign, convenience in operation, and widening of the practicality of the method.

The invention provides a preparation method of multifunctional group-substituted imidazole derivatives including derivatives of 2,4,5-trisubstituted imidazole and 2-amino-4,5-disubstituted imidazole, and the derivatives are generated by alkenyl nitrine derivatives which are easy to be synthesized chemically and leaving group-containing imine compounds under a heating condition. The preparation method provided by the invention is reasonable in design, and easily available in raw materials, needs no addition of any auxiliary additive, and is simple and convenient in operation. The polysubstituted imidazole derivatives are as shown in general formula I in the description.

The invention discloses a special catalyst for preparing o-chlorobenzonitrile by an ammoxidation method. A carrier of the special catalyst is organic silicon modified silica gel, a main catalyst comprises three components of V, P and rare earth metal Re, and a cocatalyst comprises at least one of three components of D, E and G; the active component of the catalyst is represented by VPRe<c>D<d>E<e>G<g>O<x>; the rare earth metal Re is lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium or scandium; D is titanium, chromium, molybdenum, manganese, antimony or bismuth; E is boron, iron, cobalt, nickel, zinc or tin; and G is lithium, sodium, potassium, caesium, magnesium or calcium. The invention also discloses a preparation method and application of the catalyst. The rare earth metal is used for adjusting the acidity and alkalinity, the oxidation-reduction capacity and the coordinationcapacity with reactants of the catalyst, and improving the activity of the catalyst and the selectivity of products, and the service life of the industrial catalyst is prolonged by utilizing organic silicon to reinforce the action of an inorganic oxide and the carrier. The catalyst is simple in preparation method and good in thermal stability and mechanical strength.