339 results about "Oxalic acid" patented technology

The invention belongs to the technical field of pharmaceutical chemical processes, and particularly relates to a preparation method of a penem antibiotic intermediate 4-BMA, which comprises the following steps: adding Zn powder, chlorosilane, aliphatic tertiary amine, zinc salt and 4-AA in a formula (I) into THF (tetrahydrofuran), uniformly stirring, dropwise adding a THF solution of alpha-haloamide with an induction group in a formula (II) for reaction, filtering the reaction solution, removing the zinc powder, and drying to obtain the penem antibiotic intermediate 4-BMA. Extracting the filtrate to obtain a THF phase, washing with an aqueous solution of potassium oxalate, and recovering THF to obtain a formula (III); and carrying out oxidative hydrolysis, sulfur dioxide quenching, sulfur dioxide acid regulation crystallization and recrystallization on the formula (III) to obtain the intermediate 4-BMA. According to the preparation method disclosed by the invention, a zinc salt is used as a catalyst during preparation of the formula (III), potassium oxalate is used for removing residual Zn (II) in a THF phase, SO2 is used for quenching hydrogen peroxide and acid regulation and crystallization of 4-BMA, the oxygenolysis problem of 4-BMA is solved, and the preparation method has the characteristics of greenness, safety and high efficiency, is strong in product competitive advantage and is suitable for industrial production.

The invention discloses preparation of a high-uniformity cerium oxide abrasive material and application of the high-uniformity cerium oxide abrasive material in a chemical mechanical polishing solution. According to a method, cerium nitrate or cerium oxalate is used as a cerium source, a cationic or nonionic surfactant is used as a structure-directing agent, and the high-uniformity cerium oxide abrasive material is prepared in a mixed solvent system formed by water and isopropanol or water and diethylene glycol according to a specific volume ratio. The preparation method comprises the following steps: regulating the particle size and the morphology structure through a solvothermal reaction, carrying out cleaning, drying and high-temperature calcination treatment on a reaction product to obtain sphere-like cerium oxide nano-particles with high particle size concentration ratio, moderate surface roughness and good dispersity, adding cerium oxide powder into deionized water, and carrying out ultrasonic dispersion to obtain the spherical cerium oxide nano-particles. And sequentially adding a dispersing agent and amino acid while stirring, uniformly stirring, fixing the volume, and adding a pH regulator to enable the solution to be weakly acidic, thereby obtaining the chemical mechanical polishing solution. The cerium oxide submicron powder which is different in surface appearance, particle size and distribution uniformity is prepared by adjusting the solvent ratio and other reaction conditions.

The invention discloses a preparation method of CoWO (cobalt tungsten oxide) modified NbOp-n heterojunction NbO5 / CoWO photocatalyst powder. The preparation method comprises the following steps: dissolving cobalt salt and tungsten salt in deionized water, stirring and mixing, carrying out hydrothermal reaction in an autoclave, washing and drying to obtain CoWO powder; the preparation method comprises the following steps: dissolving niobium oxalate and ammonium carbonate in deionized water, adding CoWO powder, carrying out a hydrothermal reaction in an autoclave, and carrying out washing and drying treatment to prepare NbO / CoWO photocatalyst powder. According to the method, the hydrothermal reaction temperature is regulated and controlled, and the mass ratio of raw materials is optimized, so that the catalyst forms a p-n heterojunction structure of NbOmicron flower loaded CoWOnano particles. The prepared catalyst has high norfloxacin wastewater degradation efficiency under visible light irradiation, has the advantages of simple preparation process, low reagent cost, high catalytic activity and good structural stability, and can be effectively applied to purification treatment of antibiotic polluted water.

The invention relates to the technical field of analytical chemistry, and particularly discloses a double-signal ratio type up-conversion luminescent probe, a preparation method thereof and application of the double-signal ratio type up-conversion luminescent probe in oxalate detection, and the double-signal ratio type up-conversion luminescent probe comprises up-conversion nanoparticles UCNPs and an iron-chromium cyanine R compound. The upconversion nanoparticles UCNPs are combined with the iron-chromium cyanine R compound to construct a double-emission-peak regulation and control system, when the system is used for oxalate detection, oxalate can be chelated with Fe < 3 + > in the iron-chromium cyanine R compound, blue shift of an induced absorption spectrum is achieved, green and red emission peaks of the UCNPs are synchronously regulated and controlled, and the detection sensitivity is high. The fluorescent-colorimetric bimodal high-sensitivity detection of the oxalate is realized.

The invention relates to the technical field of oxamide synthesis, and provides a microchannel reactor and a method for synthesizing oxamide by using the microchannel reactor. The micro-channel reactor sequentially comprises a feeding area, a reaction area and a discharging area along the flowing direction of reaction materials; the feeding area comprises a main feeding hole; the reaction area comprises an 8-shaped reaction flow channel, and a plurality of segmented feeding holes are formed in the reaction flow channel; the discharging area comprises a discharging opening. According to the micro-channel reactor provided by the invention, full mixing of raw materials can be realized through segmented feeding, the reaction temperature is effectively controlled, and the local temperature is prevented from being too high; when the microchannel reactor provided by the invention is used for synthesizing oxamide, the process is simple, the reaction conditions are mild, efficient conversion of oxalate can be realized in a short time, continuous production of oxamide is realized, and the microchannel reactor is suitable for industrial production.

The invention relates to the technical field of powdered ink, and discloses a plant-based environment-friendly powdered ink composition which comprises the following components: resin, a coloring agent, a charge control agent, wax / a release agent and an additive. The resin comprises polyester resin and bio-based resin. The polyester resin comprises polyhydric alcohol and polybasic acid. The polyol comprises ethylene glycol, neopentyl glycol and a bisphenol A derivative. The polybasic acid comprises terephthalic acid, isophthalic acid and oxalic acid. Compared with the prior art, the plant-based environment-friendly powdered ink composition provided by the invention has the advantages that the plant-based environment-friendly powdered ink composition is based on a plant-oil-based biodegradable material and is prepared from plant oil, polyhydric alcohols and polybasic acid compounds, so that the excellent biodegradability and moisture resistance of the plant oil are kept; and when the resin is used for preparing the biological powdered ink, the biodegradability and moisture resistance of the powdered ink can be effectively improved, and the biological powdered ink prepared from the resin has excellent biodegradability, moisture resistance, performance retentivity and fixing strength.

The present invention discloses an accordion-shaped lignin cubic carbon material, a preparation thereof, and an application thereof in a supercapacitor. The preparation method comprises the following steps: firstly, dissolving industrial lignin in an alkali solution and purifying in a weak acid solution; then forming, with a block copolymer, a mixed micelle of the lignin / the block copolymer in a mixed solvent of alcohol and water, then sequentially adding a soluble zinc salt and a soluble oxalate, and carrying out solvent evaporating induction under a neutral condition to co-deposit the mixed micelle and zinc oxalate, with an evaporation rate at the same time, to deposit the mixed micelle of lignin / block copolymer between zinc oxalate layers, to construct a cubic lignin / block copolymer / zinc oxalate complex with ordered structure; and after finally carbonizing, obtaining an accordion-shaped lignin cubic carbon material. This material has a rich ion migration space and is internally provided with interconnected supporting nanosheet layers so that the problem that carbon nanosheets are easy to accumulate is solved, the effective surface utilization rate is improved, and performances of the mass, the area-specific capacitance and the rate capability of a supercapacitor are remarkably improved.

The invention discloses a method for preparing hafnium oxide from hafnium oxalate feed liquid through an oxidation precipitation method, and belongs to the technical field of hydrometallurgy. The specific method comprises the following steps: adding an oxidizing agent into hafnium oxalate feed liquid to destroy oxalate ions in hafnium oxalate so as to enable hafnium to form hydroxide precipitates; and separating the generated white precipitate, and roasting at high temperature to obtain hafnium oxide. The strong oxidant used in the method is low in cost, high in precipitation efficiency, green, environmentally friendly, free of large pollution to equipment and the environment and wide in application range. The method is simple in process, does not involve a complex process flow, does not need precise equipment, avoids a large amount of alkali liquor required by metal ion precipitation, is simpler in process flow, higher in efficiency and lower in cost, avoids the generation of a large amount of wastewater, and is very environment-friendly. And meanwhile, the process is wide in application range and suitable for various oxalic acid metal feed liquid.

The invention belongs to the technical field of synthetic ester, and particularly relates to a preparation method of fatty acid pentaerythritol ester base oil, which comprises the following steps: carrying out esterification reaction on pentaerythritol and fatty acid in the presence of a catalyst and a color retention agent, and carrying out post-treatment to obtain the fatty acid pentaerythritol ester base oil, the catalyst comprises at least one of stannous octoate, stannous oxalate, stannous oxide, tetrabutyl titanate, isopropyl titanate and sodium hydrogen sulfate; the color retention agent comprises at least one of sodium hypophosphite, hypophosphorous acid, activated carbon and sodium sulfite. The color retention agent sodium hypophosphite is matched with the specific catalyst such as stannous oxalate, so that the petroleum color number of the produced fatty acid pentaerythritol ester base oil is smaller, and meanwhile, the esterification reaction time is shorter.

The invention discloses a method for preparing a pore-adjustable carbon molecular sieve through binary activation of heavy oil and application, and belongs to the technical field of biomass resource utilization and water treatment. The method comprises the following steps: (1) mixing heavy oil and a binary activator, and standing to form a carbon-containing precursor mixture; wherein the binary activating agent is calcium citrate and potassium oxalate; (2) performing pyrolysis activation on the carbon-containing precursor mixture in an inert atmosphere, and cooling after the pyrolysis is completed to obtain biological activated carbon; and (3) washing and drying the biological activated carbon to obtain the carbon molecular sieve. The method has the advantages of greenness, environmental protection, convenient process and efficient production. The prepared carbon molecular sieve is developed in pore structure, concentrated in pore size distribution and good in adsorption characteristic, has a wide application prospect in water treatment, and realizes comprehensive treatment of resource utilization of two pollutants, namely waste heavy oil and dye wastewater.

The utility model belongs to the technical field of oxalate storage, and particularly relates to a harmless discharging device for volatile organic gas in a dimethyl oxalate storage tank, which comprises a storage tank and a liquid seal tank, the top end of the storage tank is connected with a discharging pipe, and a pressure transmitter for detecting air pressure in the tank is fixedly mounted on the storage tank. A regulating valve I in signal connection with the pressure transmitter is mounted on the discharge pipe, one end, far away from the storage tank, of the discharge pipe extends into the liquid seal tank and is positioned below the liquid level in the liquid seal tank, methanol is contained in the liquid seal tank, and the top end of the liquid seal tank is connected with a tail gas pipe. According to the utility model, organic matter gas in the storage tank is discharged into the liquid seal tank and is washed and dissolved by methanol, so that organic matters are prevented from being discharged into the atmosphere, zero emission of harmful substances is realized, and the device is environment-friendly.

The invention relates to the field of hydrometallurgy, and discloses a method for converting hafnium oxalate feed liquid into hafnium oxychloride feed liquid, which is characterized by comprising the following steps: adding an HCl solution and an oxidizing agent into the hafnium oxalate feed liquid, and reacting at a certain temperature to obtain a hafnium oxychloride solution. The method has the advantages of simple operation, no introduction of any metal impurity ions, small reagent consumption, low energy consumption, low cost, high efficiency, no physical state change, and realization of continuous production. The method for adding the HCl solution and the oxidizing agent into the oxalate feed liquid is also suitable for converting oxalate solutions of other metal ions into chloride solutions, including but not limited to zirconium oxalate, titanium oxalate, thorium oxalate, scandium oxalate, niobium oxalate, tantalum oxalate, vanadium oxalate, cobalt oxalate, cesium oxalate and rubidium oxalate.

The invention discloses a method and device for continuously preparing lithium difluoro (oxalato) borate and a lithium difluoro (oxalato) borate solution, and belongs to the technical field of electrolyte salt synthesis, the method comprises the following steps: continuously pumping chlorosilane and a first mixed solution formed by oxalate and an ester solvent into a first dynamic microchannel reactor, and carrying out a first reaction to obtain a reaction product, wherein the mass flow ratio of the first mixed solution to the chlorosilane is (4-10): 1; continuously pumping the reaction product into a second dynamic micro-channel reactor, continuously pumping a second mixed solution formed by lithium tetrafluoroborate and an ester solvent into the second dynamic micro-channel reactor, and carrying out a second reaction at a temperature of 20-70 DEG C and a rotating speed of 200-400 r / min to obtain a mixed reaction solution; and separating a reaction product in the mixed reaction liquid to obtain the lithium bis (fluoro) oxalato borate. According to the method for continuously preparing the lithium difluoro (oxalato) borate, the continuous production of the lithium difluoro (oxalato) borate can be realized, and the quality of the lithium difluoro (oxalato) borate is high.

The invention relates to the technical field of preparation of cupanicilib, and discloses a novel preparation method of cupanicilib, which comprises the following steps: by taking vanillic acid as an initial raw material, carrying out methyl esterification, nitration, alkylation reaction with N-3-chloropropylmorpholine hydrochloride, ester group hydrolysis, condensation with urea, nitro reduction, intramolecular condensation and condensation with chloroethylamine hydrochloride to obtain cupanicilib. According to the synthetic scheme, the synthetic route is short, the raw materials are easy to obtain, the yield is high, no dangerous reaction process exists in the reaction process, a highly toxic reagent is not used, and the synthetic scheme is green and efficient.

The invention relates to a method for preparing an intermediate for synthesis of olpinapone. The method comprises the step of nitrating vanillic acid in anhydride by using a nitrating agent. The present invention also relates to an intermediate for the synthesis of olpiapone produced by this process. In addition, the present invention relates to a solution of an intermediate for the synthesis of olpiapone in an anhydride.

The present invention relates to an oxalic acid diamide compound represented by formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for the prevention or treatment of diseases or conditions associated with PRMT5 activity. # imgabs0 #

The invention belongs to the technical field of medical analysis, and particularly relates to a method for separating chemical components in hemsley rockvine root. According to the present invention, various chromatography methods are adopted to carry out separation and purification, such that sitroside (I), vanillyl glycolII (II), 5-hydroxymaltol (III), vanillic acid (IV), afzelin (V), 2, 3-dihydroxypyrazole (9E, 11E)-13-hydroxypyrazole (9, 11-dienoate), and 2, 3-dihydroxypyrazole (10E, 12E)-9-hydroxypyrazole (10, 12-dienoate) are obtained from hemsley rockvine root. Wherein the compounds II, III, VI and VII are separated from the hemsley rockvine root for the first time, and development and quality control of the hemsley rockvine root medicinal material are facilitated.

The invention discloses a reactor for treating iron and aluminum metal resources through ammonium oxalate, which is used for extracting iron and aluminum substances after the ammonium oxalate reacts with the iron and aluminum metal resources, and comprises a reaction kettle body, a stirrer, a first pipe orifice for filling high-pressure water vapor, and a second pipe orifice for relieving pressure and filling materials, the third pipe orifice is used for discharging an oxalic acid complex; the fourth pipe orifice is used for discharging ammonia steam; the first pipe orifice, the second pipe orifice and the third pipe orifice are respectively provided with a switch valve; and the fourth pipe orifice is provided with a constant pressure valve. The reaction kettle is used for reacting ammonium oxalate with iron and aluminum metal resources, and device conditions are provided for extracting the iron and aluminum metal resources through ammonium oxalate.

The application discloses a triazine ring synthesis method, and belongs to the technical field of medical intermediate synthesis. The method is characterized in that 2-methylaminothiourea and dimethyl oxalate are used as raw materials, a nanometer catalyst of scandium triflate (Sc(OTf)3) or ytterbium triflate (Yb(OTf)3) is loaded on magnetic Fe3O4@SiO2, a cyclization reaction is carried out in an organic solvent, the catalyst is separated and recovered through an external magnetic field after the reaction is completed, and high-purity triazine rings are obtained through acidification, crystallization and drying of the reaction liquid. The catalyst has the advantages of high specific surface area, high catalytic activity, easy magnetic separation and recovery, and can be reused more than 6 times. The product yield can reach 93% to 96%, and the purity is greater than or equal to 99.6%. The method realizes green, efficient and low-cost synthesis of triazine rings.

The invention belongs to the technical field of coal ethylene glycol, and particularly relates to a process and a device for finely removing impurities from carbon monoxide after cryogenic separation of synthesis gas, the device comprises an impurity removal device, the impurity removal device comprises a desulfurization tank, a dechlorination tank and a decarbonylation tank which are sequentially connected in series, or an adsorption tower which is sequentially filled with desulfurization, dechlorination and decarbonylation adsorbents; the impurity removal device is arranged to remove trace hydrogen sulfide, hydrogen chloride, carbonyl iron and carbonyl nickel in CO after cryogenic separation, so that ppb-level removal of impurities in CO is realized, poisoning of a downstream dimethyl oxalate (DMO) synthesis catalyst is avoided, the service life of the catalyst is prolonged, the production cost of an enterprise is reduced, and the operation stability of the device is improved.

The invention discloses a Hedyotis diffusa extract, comprising a hedyotis diffusa glycoside content of 2500-4000 ppm, deacetylated hedyotis diffusa methyl ester, scutellariae glycoside methyl ester, and hedyotis diffusa glycoside content of 4500-6500 ppm, a total flavonoid content of less than 100 ppm, no characteristic color reaction for anthraquinone identification, hedyotis diffusa acid content of less than 100 ppm, deacetylated hedyotis diffusa acid content of less than 100 ppm, and geniposide acid content of less than 100 ppm, and a pH value of 6.0-7.0. The extract is obtained by vacuum ultrasound, centrifugation, and vacuum concentration, followed by acid adjustment to a pH of 2.5-3.0, followed by aging, membrane filtration, and purification by ion exchange column chromatography to obtain a permeate A and a Hedyotis diffusa alkaloid eluate J1. The permeate A is filtered through a membrane, separated by molecular imprinting polymerization adsorption, vacuum concentrated, and ultrafiltered. Finally, the pH is adjusted to 6-7 with J1, and the extract is sterilized by heat preservation.

The present invention discloses a rapid hydrogen peroxide test kit and a method of using the same, the rapid hydrogen peroxide test kit comprising a sample diluent and a test strip containing a chromogen for detection and a chromogen for quality control in a dry environment. The sample diluent comprises 100-500 mM ammonium oxalate, 0.3-2.0 mM 8-hydroxyquinoline, 50-500 mM sodium chloride, and 10-100 mM of a first pH adjuster for pH 4.5-7.0.

The invention discloses a method for preparing 6N and above high-purity Nb2O5 by using a niobium oxalate precursor, belongs to the technical field of niobium pentoxide preparation, and solves the problems of low purity and high impurity content of Nb2O5 prepared by the existing method. The method comprises the following steps: mixing niobium oxalate with high-purity water to obtain a mixed solution; performing cold crystallization purification; separating niobium oxalate crystals from the mother liquor, washing and drying; the method comprises the following steps: putting niobium oxalate crystals into a crucible, putting the crucible into a vacuum reaction distillation furnace, sealing a system, vacuumizing to below 1Pa, carrying out inert gas replacement, and then carrying out stage heating and heat preservation; cooling to 800-900 DEG C, introducing high-purity oxygen into the system, and carrying out oxidation stabilization treatment at a constant temperature; after treatment, continuously cooling to 200 DEG C or below, and then naturally cooling to room temperature to obtain a high-purity Nb2O5 product. The Nb2O5 product prepared by the method disclosed by the invention is high in purity and low in impurity content.

The invention discloses a method for recovering iron resources from jarosite, which comprises the following steps: S1, reacting ammonium oxalate with jarosite to realize jarosite phase dissolution: mixing jarosite with ammonium oxalate, and heating and reacting in a water reaction system to generate ammonia gas to obtain leached residues and leached liquid; s2, the leachate reacts with ammonia to precipitate and separate iron, and ammonium oxalate is recycled: S2.1, the leachate reacts with the ammonia: ammonia gas is introduced into the leachate or ammonia water is added into the leachate for full reaction, and reaction product slurry containing ferric hydroxide precipitate and ammonium oxalate is obtained; and S2.2, separating ferric hydroxide and ammonium oxalate from the reaction product slurry: filtering and separating to obtain a ferric hydroxide precipitate, and cooling to separate out crystals from ammonium oxalate in the filtrate so as to recover ammonium oxalate. According to the method, ammonium oxalate used for replacing iron in the iron vitriol can be recycled, the raw material cost is low, iron element separation and utilization are achieved, solid waste is remarkably reduced, and enrichment of other valuable elements in the iron vitriol is facilitated.

The invention discloses a method for recovering a titanium dioxide byproduct ferrous sulfate. The method comprises the following steps: S1, dissolving a titanium dioxide byproduct ferrous sulfate in water, and filtering to obtain a first filtrate; s2, adjusting the pH value of the first filtrate to 4.5-5.5, and filtering to obtain a second filtrate; s3, adding sulfide into the second filtrate, and filtering after reaction to obtain third filtrate; s4, adding an alkaline liquid into the third filtrate, and filtering after reaction to obtain a fourth filtrate and a first filter cake, so as to obtain ferrous hydroxide with first purity; and S5, preparing ferrous oxalate dihydrate from the ferrous hydroxide with the first purity. According to the method, through the synergistic effect of accurate pH value control, sulfide impurity removal and fractional precipitation, efficient separation of iron and manganese is achieved, the complex impurity removal process of multiple oxidation reduction is avoided, the operation process is simple, ferrous oxalate dihydrate is prepared after high-purity ferrous hydroxide is prepared, and the impurity removal cost is low.

The present invention is a platinum (II) oxalate compound of the formula: wherein R1, R2 and R3 are as defined herein. The platinum (II) oxalate compound of the present invention can be used as a catalyst in a hydrosilylation reaction, especially in the hydrosilylation of curable siloxanes.

The invention relates to the field of hydrometallurgy, and discloses a method for converting hafnium oxalate feed liquid into hafnium sulfate feed liquid, which comprises the following steps: adding a sulfuric acid solution and an oxidizing agent into the hafnium oxalate feed liquid, and reacting at a certain temperature to obtain the hafnium sulfate feed liquid. Oxidants used in the method are preferably hydrogen peroxide and ozone, other impurity ions are not introduced, and the purity of the product is not influenced at all. Oxidation products are H2O and CO2 and are basically free of pollution to the environment. The process of evaporation, filtration, calcination, redissolution and the like of a traditional evaporation method and an alkali precipitation-redissolution method is not needed, the operation is simple, the efficiency is high, the cost is low, and the operability is high. The method for adding the sulfuric acid solution and the oxidizing agent into the oxalate feed liquid is also suitable for converting oxalate solutions of other metal ions into sulfate solutions, including but not limited to zirconium oxalate, titanium oxalate, thorium oxalate, scandium oxalate, niobium oxalate, tantalum oxalate, vanadium oxalate, cobalt oxalate, cesium oxalate and rubidium oxalate.

This invention provides an antistatic agent that complies with PFAS regulations, exhibiting excellent resin compatibility and exhibiting sufficient antistatic performance with only a small amount of additive. [Solution] An antistatic agent comprising one or more onium salts selected from formulas (1) and (2). TIFF2026058576000010.tif23169 TIFF2026058576000011.tif25168 (In the formula, R1 to R4 are alkyl groups that may be the same or different, X represents an alkyl chain or a heteroatom-containing alkyl chain, and Y is a bisfluorosulfonyliimide or bisoxalatoborate anion.)

The invention discloses a template agent P123-based 3DNSi / Nb-O composite material, niobium oxalate is used as a niobium source, ammonium fluotitanate is used as a titanium source and a fluorine ion regulator, boric acid is used as the fluorine ion regulator, and P123 is used as a template agent, and the preparation method comprises the following steps: firstly, preparing 3DNSi / Nb-O through a hydrothermal method, and then carrying out heat treatment to remove P123. The 3DNSi / Nb-O is anatase type TiO2, and the Nb element is doped into a TiO2 crystal lattice; the oxygen vacancy microstructure is of a three-dimensional structure composed of nanosheets; and the specific surface area is 25-35 m < 2 > / g. The niobium source is niobium oxalate; the titanium source is ammonium fluotitanate; the fluorine ion regulator is boric acid, and in addition, the ammonium fluotitanate is also the fluorine ion regulator; the template agent is P123. The invention discloses a magnesium hydride composite hydrogen storage material based on 3DNSi / Nb-O and a preparation method of the magnesium hydride composite hydrogen storage material. The initial hydrogen desorption temperature of the obtained MH-3DNSi / Nb-O is 185-230 DEG C; the hydrogen desorption amount is 6.0 to 6.5 weight percent; when the number of times of hydrogen absorption and desorption is 1000-1500, the hydrogen storage capacity is not obvious, and the hydrogen desorption capacity is kept at 6.9-7.1 wt.%.

The invention belongs to the technical field of NO gas preparation in the production process of coal ethylene glycol devices, and discloses a start-up method of an NO gas production device in coal ethylene glycol, which comprises the following steps: step 1): preparing materials; according to the driving method disclosed by the invention, key process indexes such as nitric acid dropping speed, pressure, temperature and NO gas flow are strictly controlled in the whole driving process, so that severe reaction and overpressure safety accidents are prevented, and the gas quantity required by a downstream dimethyl oxalate synthesis unit is stably supplied.