53 results about "Ethyl nitrite" patented technology

The invention discloses a method for preparing diethyl oxalate by CO coupling reaction. By applying a gas phase method, CO is coordinated with ethyl nitrite and is catalyzed by bimetallic supported catalyzer to couplingly generate crude diethyl oxalate, the reaction is a self-sealing circulation process, the CO gas mixed with the ethyl nitrite coming from a regeneration reactor is preheated and then enters into a coupling reactor, after the reaction, the gas is separated by condensation, so that the colorless and transparent condensed diethyl oxalate liquid is produced, and the uncondensed gas containing NO enters into the regeneration reactor to react with ethanol and oxygen in order to generate ethyl nitrite which is again circulated back to the coupling reactor for continuous use. The invention is carried out on the basis of previous laboratory research and under the background of industrial production and fulfils the continuous run examination of the bench scale test and pilot magnification under the condition of industrial operation, the temperature of the coupling reaction is low, and the concentration of products is increased. The method has the advantages of more energy saving, no pollution and high benefit. The total conversion rate of the CO generated by reaction is one hundred percent, and the selectivity of diethyl oxalate is over ninety six percent.

Treatment of pulmonary disorders associated with hypoxemia and / or smooth muscle constriction and / or inflammation comprises administering into the lungs as a gas compound with an NO group which does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and / or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.

Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N2O3, HNO, and H2S. Optionally, N-acetylcysteine, ascorbate, H2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.

The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethyl nitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitro-N-acetyl cysteine. As shown in FIG. 1C the ability of endogenous SNOg to increase VE in freely behaving, conscious rates using whole-body plethysmography revealed that CSNO, GSNO and CGSNO (1 nmol each) caused equivalent increases in VE, whereas D-CSNO had no effect (left bar graph is the equivalent increases in VE, whereas D-CSNO had no effect (left bar graph is the control whereas the right bar represents administration of the respective SNO).

The invention discloses a catalyst for the synthesis of diethyl oxalate employing carbon monoxide gas-phase catalytic coupling and the catalyst adopts metal palladium as active component, alpha-Al2O3 as carrier and transition metal copper as promoter; wherein, the content of metal palladium is 0.1-5.0% of the carrier and the content of transition metal copper is 0.05-3.0%. The catalyst shows higher reactivity and higher time space yield of dimethyl oxalate in the reaction that carbon monoxide and ethyl nitrite are used to synthesize dimethyl oxalate. The invention also discloses a preparation method of the catalyst.

The invention provides a preparation method of sodium azide. The preparation method comprises the steps of adding sulfuric acid to a solution consisting of an ethanol, a sodium nitrite, introducing the produced ethyl nitrite gas into a mixture consisting of a hydrazine hydrate, a sodium hydroxide, a catalyst, and an ethanol, and after the gas is introduced, carrying out a reaction for 1.5 to 2.5h at a temperature of 18 to 25 DEG C. The preparation method provided by the invention which adopts one step to prepare the sodium azide has the advantages of simple production process and easy operation. Since just one step is adopted, the intermediate product is not wasted, the product yield is greatly improved, the yield is more than 90%, the product qualification rate is great, and the purity is more than 99%.

The invention discloses a making method of sodium azide, which comprises the following steps: dripping sulfuric acid in the solution with alcohol, sodium nitrite and water; aerating ethyl nitrite gas into solution with hydrazine hydrate, sodium hydroxide, tetrabutylammonium bromide and alcohol; generating sodium azide; evaporating solvent; crystallizing; separating solid from liquid to obtain the product.

Treatment of pulmonary disorders associated with hypoxemia and / or smooth muscle constriction and / or inflammation comprises administering into the lungs as a gas a compound with an NO group which does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and / or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite. Treatment of patient in need of improved oxygenation, blood flow of and / or thinning of blood comprises providing in the patient a therapeutic amount of red blood cells loaded with nitrosylated hemoglobin. A method is directed to screening drugs that increase level of nitrosoglutathione in airway lining fluid.

The invention discloses an aqueous-phase synthetic method of sodium azide with n-butyl alcohol being circularly recycled, wherein the method includes following steps: (1) mixing butyl nitrite, sodium hydroxide, hydrazine hydrate, a catalyst and water to form a reaction system; (2) after the reaction finished, recycling the n-butyl alcohol and water; and (3) filtering a reaction solution to obtain a sodium azide (white solid) and circularly recycling the recycled n-butyl alcohol. In the method, by means of the butyl nitrite for synthesizing the sodium azide, so that compared with a synthesis route from ethyl nitrite, the synthetic method is free of high-pressure operations and the risk of leakage of gas. Meanwhile, the reaction can be carried out in the aqueous phase and just needs to added with the catalyst in a micro amount (especially, herein the catalyst may be composited of tributylamine and methanol), so that the synthetic method is environmental-protective. The method is high in yield of product, is low in the content of free alkali and is high in product purity. Meanwhile, the reaction achieves the recycle of a by-product n-butyl alcohol for synthesizing the butyl nitrite, by means of the technical scheme, the environmental pollution is reduced while the economic benefit is increased.

The invention provides a preparation method for ethyl nitrite standard air. The method comprises the following steps of: a 1, inducing inert gas into a clean sealed flexible container; a 2, injecting ethyl nitrite standard liquid into a clean sealed ampoule bottle through a micro-chromatograph sample-injecting needle; a 3, placing the ampoule bottle in a sealed container 2, and slowly flushing the container 2 by using the inert gas in the flexible container so as to exhaust the air in the container 2; a 4, pumping the container 2 until the pressure in the container 2 is negative, and sealing the container 2; a 5, shaking the container 2 forcefully to smash the ampoule bottle, after the ethyl nitrite is completely volatilized, continuously supplementing the inert gas into the container 2, and after the air pressure in the container 2 is in balance with the external atmosphere pressure, sealing the container 2 again; and a 6, shaking the container 2 slightly to fully mix air so as to prepare the ethyl nitrite standard air. The standard air prepared by the method is purer and more accurate and is more quickly prepared. The method is usually applied to fields, such as environment and medicine.

The invention provides a preparation method for ethyl nitrite standard gas. The method comprises the following steps of: a1, pre-treating a container used in the preparation method; a2, vacuating the container and sealing; a3, absorbing liquid ethyl nitrite into a syringe, and weighing the total mass m1 of the syringe and the liquid ethyl nitrite; a4, weighing mass m2 of the syringe; and a5, introducing diluents into the container to obtain the ethyl nitrite standard gas. The ethyl nitrite standard gas prepared by the preparation method is accurate and reliable in gas concentration. Industrial ethyl nitrite standard gas can be prepared easily and quickly by the method, the standard gas is provided for detecting ethyl nitrite, and the method has industrial application significance.

The invention provides a preparation method for ethyl nitrite standard gas. The method includes the following steps: (a1) ethyl nitrite solution is filled into a vacuum constant-temperature reaction kettle and kept for 2 hours, wherein the temperature in the vacuum constant-temperature reaction kettle is kept at 25 DEG C until the ethyl nitrite solution becomes saturated vapor; (a2) the saturated ethyl nitrite vapor is quantitatively transferred into a sample loop; (a3) the saturated ethyl nitrite vapor in the sample loop is put into a standard gas bottle; (a4) steps a1 to a3 are repeated in order to regulate the volume of the saturated ethyl nitrite vapor entering the standard gas bottle; (a5) inert gas used as diluting gas is filled into the standard gas bottle; (a6) the ethyl nitrite standard gas is obtained. The concentration of the ethyl nitrite standard gas prepared by the preparation method is accurate and reliable. The usage of the method can easily and conveniently prepare the industrial ethyl nitrite standard gas, provides standard gas for the industrial test of ethyl nitrite, and is highly significant in industrial application.

The invention relates to a synthetic method of a 2,2-diethoxy acetophenone photoinitiator, which comprises the following steps: a, synthesizing ethyl nitrite, namely mixing ethanol with 28 percent of aqueous solution of sodium nitrite in a reaction kettle with mechanical stirring and a gas ingress pipe, dripping 20 percent dilute sulphuric acid into the mixture at the temperature of between 20 and 30 DEG C to generate ethyl nitrite gas, and directing introducing the generate ethyl nitrite gas into the step b for reaction, wherein the molar ratio of the ethanol to the sodium nitrite to the dilute sulphuric acid is 1.00:1.09 to 1.68:1.10 to 1.18; and b, synthesizing 2,2-diethoxy acetophenone, namely introducing the ethyl nitrite gas generated by the step a into acetophenone and 36 percent hydrogen chloride ethanol solution, and neutralizing the mixture by using sodium hydroxide solution after a reaction ends to prepare finished products, wherein the molar ratio of the acetophenone to the hydrogen chloride ethanol solution is 1:1. The synthetic method is simple and convenient in process and high in product yield and is suitable for industrial production.

The invention relates to a catalyst for synthesizing diethyl oxalate by CO gas-phase coupling of ethyl nitrite and a preparation method thereof. The catalyst comprises a carrier, an active component palladium and a metal auxiliary agent iron, wherein the carrier is commercial hollow columnar [alpha]-Al2O3, the content of the active component palladium accounts for 0.1-1.0 wt% of the weight of thecarrier, and the content of the metal auxiliary agent iron accounts for 0.1-1.0 wt% of the weight of the carrier. According to the preparation method, a commercial hollow columnar carrier is adopted,and vegetable tannin and / or anhydrous dextrose and / or polyvinylpyrrolidone are / is added, so that palladium metal nanoparticles in the catalyst are smaller, the dispersity is higher, and the palladiumloading capacity is lower. The catalytic activity of the catalyst is basically improved by more than two times, the cost of the catalyst is reduced by more than four times, the prepared catalyst carrier is suitable for filling of a fixed bed with high space velocity by taking industrialization as a reference, and more precious experience is provided for industrialization of diethyl oxalate production.

The invention discloses a method for treating ethyl nitrite in sodium azide synthesis tail gas and belongs to the technical field of tail gas treatment. The method comprises the step of leading ethyl nitrite air flow into an absorption liquid containing urea, hydrogen ions and nitrate. The method is low in cost, the reaction is mild, the concentration of ethyl nitrite in the tail gas can be greatly reduced, and the treatment efficiency is 99.1%. The method can effectively protect the environment and have very good economic benefits and social benefits.

A process for preparing the floatation agent "Cupferron" for dressing ore includes such steps as preparing beta-phenyl hydroxylamine solution, cooling to 2-10 deg.C, reacting on ammonia and ethyl nitrite and pressure-reduction distilling for concentrating. Its advantages are high content up to 20%, reduced pollution and low cost.

The invention belongs to the technical field of diethyl oxalate production and specifically relates to an ethyl nitrite regeneration technological method and device used in a diethyl oxalate production process, which improve nitric oxide utilization rate in the regeneration process and reduce ethanol usage quantity. The device comprises a rotating packed bed, the gas inlet of the rotating packed bed is respectively connected with a nitrogen source, an oxygen source and a nitric oxide source, the liquid inlet is connected with an ethanol storage tank, the liquid outlet is connected with the inlet of an ethanol and water mixture storage tank, and the gas outlet is connected with a condenser I. The technological process comprises the following steps of: starting the rotating packed bed, carrying out contact reaction on nitric oxide, nitrogen, oxygen and absolute ethyl alcohol in the rotating packed bed to generate a gas phase and a liquid phase, condensing discharged gas phase and makingthe liquid phase flow into the ethanol and water mixture storage tank. The technological method has the advantages of high reaction efficiency, efficient utilization of all NO (nitric oxide) and little investment, and the device has the advantages of compact and simple structure, small size, convenience for operation, little energy consumption, simple processes, convenience for starting and stopping and the like.

The invention relates to a qi-blood exchange blood oxygen saturation monitoring device. The device comprises a qi-blood exchange chamber and a blood oxygen detection part; the qi-blood exchange chamber is divided into three cavities by two gas-permeable films, the three cavities comprise a blood cavity positioned in the middle and an ethyl nitrite mixed gas cavity and an oxygen cavity which are positioned at two sides of the blood cavity respectively, and an ethyl nitrite mixed gas in the ethyl nitrite mixed gas cavity and oxygen in the oxygen cavity respectively permeate the two gas-permeable films and enter blood in the blood cavity for qi-blood exchange; and the blood oxygen detection part is a photoelectric blood oxygen detector and is used for detecting the blood oxygen saturation of the blood after the qi-blood exchange. The qi-blood exchange is carried out by permeating the gas-permeable films through adopting the device in order to improve the oxygen content of the blood; whether the exchanged blood has a full oxygen content or not is detected through the blood oxygen detection part; and the adoption of the photoelectric blood oxygen detector enables the accuracy to be high and the blood oxygen detection accuracy to be improved.

The invention relates to a catalyst for synthesizing diethyl oxalate by carbon monoxide gas-phase coupling of ethyl nitrite and a preparation method and application thereof. The catalyst comprises a carrier, an active component palladium and a metal auxiliary agent iron, wherein the carrier is commercial Raschig ring columnar [alpha]-Al2O3, the content of the active component palladium accounts for 0.1-1.0 wt% of the weight of the carrier, and the content of the metal auxiliary agent iron accounts for 0.1-1.0 wt% of the weight of the carrier. According to the preparation method, a commercial Raschig ring columnar carrier is adopted, and methyl cellulose and / or citric acid and / or microcrystalline cellulose are / is added as co-stabilizers, so that the active component palladium is relativelyuniformly distributed on the carrier in a nanoparticle state. The catalytic activity is basically improved by more than 2 times, the cost of the catalyst is reduced by more than 5 times, the catalystis suitable for filling of a high-airspeed fixed bed, and a way is opened up for large-scale production of diethyl oxalate.

The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, alleviating contraction or spasm of gastrointestinal smooth muscle to facilitate a diagnostic medical procedure and treating or preventing a gastrointestinal disorder using the compositions of the invention.

The invention provides a preparation method for ethyl nitrite standard gas. The method comprises the following steps of: a1, pre-treating a container used in the preparation method; a2, vacuating the container and sealing; a3, absorbing liquid ethyl nitrite into a syringe, and weighing the total mass m1 of the syringe and the liquid ethyl nitrite; a4, weighing mass m2 of the syringe; and a5, introducing diluents into the container to obtain the ethyl nitrite standard gas. The ethyl nitrite standard gas prepared by the preparation method is accurate and reliable in gas concentration. Industrial ethyl nitrite standard gas can be prepared easily and quickly by the method, the standard gas is provided for detecting ethyl nitrite, and the method has industrial application significance.

The invention discloses a method for treating waste gas in ethyl nitrite production process, belonging to the technical field of environmental protection. The method comprises the following steps: introducing gas flow containing ethyl nitrite and nitric oxides into absorption liquid containing urea, hydrogen ions and nitrate for reacting. According to the method disclosed by the invention, the cost of treating the produced waste gas mixed with nitric oxides and ethyl nitrite during ethyl nitrite protection is low, the reaction is mild, the concentration of the ethyl nitrite in tail gas can be greatly reduced, the environment can be effectively protected, and the method has excellent economic benefits and social benefits.

The invention relates to a detection device of ethyl nitrite gas-blood exchange rate, which comprises a gas-blood exchange cavity and a gas-chromatography-mass-spectrometer, wherein the gas-blood exchange cavity is separated into two cavities by a ventilated membrane; the two cavities comprise a blood cavity to accommodate blood and a gas cavity to accommodate ethyl nitrite mixed gas; the ethyl nitrite mixed gas can penetrate through the ventilated membrane to enter the blood in the blood cavity to exchange air and blood; and the gas-chromatography-mass-spectrometer is used for analyzing the ethyl nitrite content of the ethyl nitrite mixed gas after the gas-blood exchange and the ethyl nitrite mixed gas before the exchange. The detection device can penetrate ethyl nitrite mixed gas into the blood through the ventilated membrane, improves the oxygen content of the blood through the gas-blood exchange, meanwhile detects the blood on-line by adopting the gas-chromatography-mass-spectrometer, and confirms the exchange rate of the ethyl nitrite.

The invention discloses a preparation method of an intermediate of iodosulfuron-methyl sodium. The intermediate is obtained by performing a reaction on 6-aminosaccharin and potassium iodide in the presence of alkyl nitrite and acetic acid in one step, wherein a molar ratio of the potassium iodide to the 6-aminosaccharin is 1:1 to 1.2:1; a molar ratio of the alkyl nitrite to the 6-aminosaccharin is0.95:1 to 1:1; the alkyl nitrite is ethyl nitrite, isopropyl nitrite, n-butyl nitrite or isoamyl nitrite; and a molar ratio of the acetic acid to the 6-aminosaccharin is 1:1 to 1.2:1. According to the method provided by the invention, the alkyl nitrite is adopted for diazotization, the potassium iodide is added at the same time, so that decomposition and hydrolysis of a diazonium salt can be avoided, and the reaction yield is greatly improved; and the method does not require a large amount of water as a solvent and only adopts a small amount of water to wash an organic layer in the post-treatment, and therefore wastewater produced by adopting the method provided by the invention does not exceed 2 times the weight of the target product.

The invention discloses a synthesizing method of cinchodiketone monooxime, which comprises the following steps: adopting 2-octanone as raw material; setting the molar rate of 2-heptanone and amyl nitrite at 1: 0.6-1: 3; dripping amyl nitrite in the condition of dilute alcaine as raw material to react at 20-100 Deg C for 2-10h.

The invention relates to a qi-blood exchange blood oxygen saturation monitoring device. The device comprises a qi-blood exchange chamber and a blood oxygen detection part; the qi-blood exchange chamber is divided into three cavities by two gas-permeable films, the three cavities comprise a blood cavity positioned in the middle and an ethyl nitrite mixed gas cavity and an oxygen cavity which are positioned at two sides of the blood cavity respectively, and an ethyl nitrite mixed gas in the ethyl nitrite mixed gas cavity and oxygen in the oxygen cavity respectively permeate the two gas-permeable films and enter blood in the blood cavity for qi-blood exchange; and the blood oxygen detection part is a photoelectric blood oxygen detector and is used for detecting the blood oxygen saturation of the blood after the qi-blood exchange. The qi-blood exchange is carried out by permeating the gas-permeable films through adopting the device in order to improve the oxygen content of the blood; whether the exchanged blood has a full oxygen content or not is detected through the blood oxygen detection part; and the adoption of the photoelectric blood oxygen detector enables the accuracy to be high and the blood oxygen detection accuracy to be improved.