The invention belongs to the field of pharmaceutical and
chemical engineering, relates to a green preparation method of an anti-influenza
virus derivative key intermediate dibenzoselenoheptanone compound, and belongs to the field of pharmaceutical and
chemical engineering. According to the preparation method, N, N-
dimethylformamide and
oxalyl chloride are utilized to perform in-situ activation on
carboxylic acid to obtain an
acyl chloride intermediate, then an intramolecular Friedel-Crafts
acylation reaction is performed under promotion of cheap lewis acid
anhydrous AlCl3 or FeCl3 and
superacid TMSOTf, the dibenzoselenoheptanone compound is efficiently prepared, and particularly, the invention relates to preparation of 7, 8-difluorodibenzo [b, e] selenoheptyl-11 (6H)-
ketone. According to the synthesis method disclosed by the invention, the use of polyphosphoric acid in an existing synthesis
route is avoided, and the reaction is completed in a mild temperature range of 0-25 DEG C by introducing
superacid, so that the problem that the dibenzoselenoheptanone compound is unstable at a high temperature and is difficult to prepare is effectively solved; and meanwhile, the harsh requirement of repeated heating and cooling in the original process is avoided, the reaction time is remarkably shortened, the
energy consumption is reduced, the comprehensive production cost is effectively reduced while the
process safety is improved, and the method is more in line with the production concept of green
chemical industry.