35 results about "Gastrointestinal smooth muscle" patented technology

The invention provides isolated polypeptides that stimulate gastrointestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine navel paste for treating infantile diarrhea. The traditional Chinese medicine navel paste is prepared from the following medicinal raw materials: root of lobed kudzuvine, liquorice root, immature bitter orange, Chinese thorowax root, white peony root, coptis chinensis, medicated leaven, scorched hawthorn fruit, common ginger, medicinal evodia fruit, clove, cassia bark, costustoot, Indian buead, tuber fleeceflower stem and hirsute shiny bugleweed herb. According to the traditional Chinese medicine navel paste disclosed by the invention, a conventional treatment method for only treating symptoms of diarrhea without treating the root causes can be broken, various medicines are adopted, the digestive functions can be improved, the body fluid metabolism can be regulated, the yin and yang equilibrium can be corrected, the gastrointestinal smooth muscle spasm can be relieved, and thus the purposes of stopping diarrhea and relieving pain can be achieved; and the traditional Chinese medicine navel paste has the advantages of good curative effect, high cure rate, no toxic or side effects and convenience in use in the treatment of infantile diarrhea.

A valerian extract with calming and anti-spasm activity, its medicines for treating the spasm of cardiac blood vessel, respiratory tract and enterogastric tract and increasing the acidity of gall, and its preparing process are disclosed. Said extract contains valerian oil and valerianine (10-90%).

The invention discloses a new use of patchoulicalcohol, that is, an application of patchoulicalcohol in the preparation of medicines or health products for preventing and treating gastric motility disorders. Researches in the invention show that patchoulicalcohol can inhibit the contraction of gastrointestinal smooth muscles, can inhibit the relaxation of the gastrointestinal smooth muscle, and can reduce the overall tension level of the gastrointestinal smooth muscles; and patchoulicalcohol can selectively block the nerve conduction of the smooth muscles, has a significant curative effect on gastrointestinal motility disorders, and is dose dependent. The invention provides a new medicine choice for the gastrointestinal motility disorders, and also provides a new research approach to explore gastrointestinal nerve conduction antagonists. Patchoulicalcohol has no dose toxicity or genetic toxicity and is highly safe, so the daily application dosage is not strictly restricted from a security point of view, the dosage can be adjusted according to practical conditions, so the wide application of patchoulicalcohol is guaranteed, and patchoulicalcohol has a very good popularization application prospect.

The invention relates to a Chinese medicament composition with the function of bidirectionally regulating the smooth muscular contraction in gastrointestinal tract, which is measured by weight (briefly marked by share) and contains synephrine 5-24 parts, hesperidin 2-10 parts, and paeoniflorin 5-24 parts, or synephrine 5-24 parts, hesperidin 2-8 parts, paeoniflorin 5-24 parts, new hesperidin 1-5 parts, maringin 8-40 parts, and limonene 2-10 parts. In comparison with the prior Chinese medicament compositions which take original medicamnet as raw materials, the invention has the function of bidirectionally regulating the smooth muscular contraction in gastrointestinal tract, and has the advantages of reducing the possibility of side effect caused by unknown component of traditional Chinese medicine compositions, easily standardizing and the like.

The invention aims to provide a traditional Chinese medicine for treating and / or preventing gastrointestinal dysfunction caused by critical diseases. The traditional Chinese medicine is prepared from the following raw materials: radix codonopsis, fried largehead atractylodes rhizome, poria cocos, honey-fried licorice root, Chinese yam, white hyacinth bean, coix seed, villous amomum fruit, balloonflower root, pomegranate rind, myrobalan, and red halloysite. The traditional Chinese medicine is prepared according to the theories of tonifying qi, invigorating the spleen, upbearing the clear, and downbearing the turbid, has an integral conditioning effect by simultaneously eliminating and supplementing; can promote the peristalsis and propulsion of gastrointestinal smooth muscle, improves the blood circulation of the intestinal walls, reduces the capillary permeability of the gastrointestinal tracts, relieves the tissue edema, promotes the discharge of dead tissues, inhibits the intestinal bacterium translocation and toxin absorption in the intestines, eliminates the free radicals, and antagonizes the system inflammation reaction. The traditional Chinese medicine for treating gastrointestinal dysfunction caused by critical diseases has a good effect, can control the incidence rate of gastrointestinal dysfunction below 19.05%, does not have any side or toxic effect during the clinical process, and is reliable and safe.

The invention relates to a medicine for treating stomach diseases, more specifically a traditional Tibetan medicine pill for strengthening the spleen and stomach. The medicine for treating stomach diseases is prepared from the following active pharmaceutical ingredients: myrobalam, tsaoko, calcite, travertine, pterocephalus hookeri heck, nutmeg, Herpetospermum pedunculosum, clove, safflower, pomegranate, costus root, pawpaw, honey, agilawood, Saxifrage, Zhaxun and cardamom. A preparation method comprises the following steps: pretreating raw materials, processing the medicines, pulverizing, sterilizing, screening, mixing, making into pills, baking, polishing, packaging and warehousing. The invention has the effects of strengthening the spleen and stomach, relieving pain, preventing or arresting vomiting, separating clear and excreting turbid, quickly reliving the spasm of the gastrointestinal smooth muscles, and improving the gastrointestinal functions so as to alleviate pain, eliminate gasterectasis, and belching and the like; and the invention can effectively kill Helicobacter pylori, resist inflammation, soothe the gastric acid, form a gastric mucosa protective shield, enhance the gastric mucosa blood flow and promote the restoration of the gastric mucosa, thereby thoroughly relieving the diseases. The invention has the advantages of quick effect taking, favorable curative effect, short treatment course, no side effect and high safety and reliability, is convenient to use, is a branded product of Tianzhu Traditional Tibetan Medicine, and is well welcomed by massive people and patients.

The invention belongs to the field of health-care food, and discloses digestion-assisted carrot colored noodles and a preparation method thereof. The noodles are prepared from the following raw materials in parts by weight: 0.2 to 0.4 part of patchouli essential oil, 0.3 to 0.4 part of astragaloside, 0.28 to 0.32 part of a rhizoma cyperi extract, 0.02 to 0.04 part of marine coccolith selenide, 4 to 6 parts of eggs, 18 to 22 parts of celeries, 28 to 32 parts of carrots, 0.8 to 1.2 parts of edible salt, 0.4 to 0.5 part of sodium carboxymethylcellulose, 0.25 to 0.35 part of xanthan gum, 0.22 to 0.23 part of sodium alginate and 100 parts of flour. The noodles can promote the gastric emptying function by adjusting shrinkage of gastric and intestinal smooth muscles and adjusting the gastrin level, so as to increase the gastrointestinal motility, thereby promoting intestines and stomach digestion of middle-aged persons, improving dyspepsia and maintaining the mobility and health of the gastrointestinal tract.

The invention discloses novel pharmaceutical application of sodium aescinate and in particular discloses application of sodium aescinate in preparation of spasmolysis medicines for treating gastrointestinal smooth muscle spasm. The sodium aescinate has an obvious tension reduction effect on gastric tissue spasm caused by acetyl choline and can be used for treatment of diseases caused by gastrointestinal smooth muscle spasm such as acute gastroenteritis, colonitis, peptic ulcer, acute intestinal obstruction and the like. The clinical tests prove that the sodium aescinate has an obvious effect of treating gastric and intestinal colic caused by smooth muscle spasm, the total effective rate reaches 96.7%, and compared with atropine, the sodium aescinate does not have any obvious curative effect difference while is small in side effects.

The invention discloses a Chinese herbal medicine goat feeding promoting agent which comprises the following raw material components by weight: 10-15 parts of orange peel, 10-15 parts of hawthorn, 5-10 parts of semen strychni, 10-15 parts of Lysimachia sikokiana, 5-10 parts of areca, 1-5 parts of amomum, 5-10 parts of fennel, 10-15 parts of sesame and 5-10 parts of Ferula asafoetida; the Chinese herbal medicine goat feeding promoting agent is prepared from Chinese herbal medicines with the effect of promoting appetite, tonifying spleen, strengthening spleen and benefiting qi and mild stimulation effect on intestines and stomach as main raw materials, and the Chinese herbal medicine goat feeding promoting agent can promote the secretion of digestive juice, has the effect of eliminating intestinal pneumatosis, helping digestion, guiding qi, normalizing spleen and stomach operation, improving appetite, increasing feed intake, promoting the secretion of large amount of saliva, gastric juice, pancreatic juice and bile, exciting gastrointestinal smooth muscle, accelerating gastrointestinal peristalsis and accelerating the absorption speed of nutrients, has antibacterial and antimicrobial effect, can improve the body specific and non-specific immunity, reduces the incidence of diseases, and is anti-stress. The Chinese herbal medicine goat feeding promoting agent is wide in source, low in cost, rich in minerals and vitamins, has the effect of disease resistance and stress resistance, and improves production efficiency.

The invention belongs to the technical field of beer brewing, and particularly relates to beer with peach blossom and a preparation method of the beer. The beer with the peach blossom is prepared fromthe following raw materials in percent by weight: 10-20% of barley malt, 10-15% of wheat, 25-30% of peach blossom extract, 2-5% of white granulated sugar, 0.1-0.3% of humulus lupulus, 0.2-0.4% of yeast, 0.1-0.5% of edible spice and 40-50% of water. The beer with the peach blossom provided by the invention has the beneficial effects that by containing rich kaempferol, carotene and multiple vitamins and trace minerals, the peach blossom has the effects of promoting uresis and activating blood circulation, and also has the functions of promoting secretion of gastric juice, bile, pancreatic juiceand intestinal juice and promoting contraction and peristalsis of gastrointestinal smooth muscles; the beer with the peach blossom not only maintains the flavor of beer, but also has fragrance of theblossom, is strong in beer fragrance and blossom fragrance, rich in nutrition and high in nutritional value, and has a certain health-care function, the preparation method is simple, and suitabilityfor industrialized production is achieved.

The invention relates to a veterinary drug composition for preventing porcine diarrheal disease. The composition is prepared from 5-35 parts of enrofloxacin, 5-35 parts of sulfadiazine sodium, 5-30 parts of TMP, 10-35 parts of radix sophorae flavescentis extract, 8-35 parts of rhizoma atractylodis macrocephalae extract, 10-35 parts of radix pulsatillae extract, injection water and the like. The veterinary drug composition provided by the invention has the characteristics of clearing heat and removing toxin, fighting bacteria and diminishing inflammation, astringing intestines and checking diarrhea, clearing bowels and killing worms, promoting digestion and removing mass, promoting digestion, draining water and dispersing swelling, promoting discharge of enterotoxin, accelerating repair of intestinal mucosa, enhancing the contraction of gastrointestinal smooth muscle and the like, and can effectively prevent the porcine diarrheal disease; moreover, the veterinary drug composition can effectively prevent the yellow and white scour of piglet, and realizes an obviously effect of early prevention of porcine edema disease; by injecting the veterinary drug composition into the newly born piglet, the piglet can be protected from the yellow and white scour and edema disease throughout the life; and by injecting the veterinary drug composition into the livestock before birth, after birth, during weaning, after purchasing and in long-distance transportation, the disease can be effectively prevented.

The optically pure R(-)-isomer of oxybutynin and the optically pure R(-)-isomer of desethyl-oxybutynin, which are substantially free of the corresponding S(+)-isomers, are potent anticholinergic spasmolytics, useful for relief of symptoms associated with urinary bladder smooth muscle hyperactivity, such as Urinary Incontinence and gastrointestinal smooth muscle hyperactivity, such as Irritable Bowel Syndrome. Methods are disclosed utilizing the optically pure R(-)-isomers of oxybutynin and desethyloxybutynin for treating cholinergically mediated smooth muscle hyperactivity while minimizing the side effects associated with administration of racemic oxybutynin or racemic desethyloxybutynin.

The invention discloses a medicinal preparation used for protecting the livestock and poultry from diarrhea, which comprises the following raw materials by weight ratio: 1-20 parts of Radix Astragali, 1-20 parts of bighead atractylodes rhizome, 1-20 parts of licorice, 2-40 parts of white peony root, 20-150 parts of Limonite, 20-150 parts of red halloysite, 2-20 parts of pomegranate rind, 20-100 parts of alum, 3-30 parts of radix bupleuri, 4-10 parts of cimicifuga foetida, 1-20 parts of coptis and 0-3 parts of diphenoxylate. The components of the medicinal preparation are direct and mutual synergism, and has efficacy of supplementing the center and boosting qi, lifting up Yang and depression, antidarrhea with astringent, inhibiting smooth muscle spasm of gastrointestinal tract and alleviating peristaltic of gastrointestinal tract, and is capable of rapidly recovering the functions of gastrointestinal tract, thereby, the medicinal preparation has an obvious function of weight increasing.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine navel plaster for infantile diarrhea. The traditional Chinese medicine navel plaster is characterized by comprising main materials and auxiliary materials, wherein the main materials include in parts by weight, 5-7 parts of scandent hop, 3-4 parts of cinnamon, 3-5 parts of pepper, 3-4 parts of dried ginger and 3-4 parts of gallnut, and the auxiliary materials include in parts by weight, 3-5 parts of wool grease, 4-6 parts of Vaseline and 4-6 parts of glycerin. The invention further provides a preparation method of the traditional Chinese medicine navel paste for the infantile diarrhea. The preparation method includes the steps: baking and pulverizing the main materials, adding 75% of ethyl alcohol, performing reflux extraction at the temperature of 80 DEG C for 0.5-2 hours and filtering, concentrating and drying extracting solution to obtain extract; proportionally mixing the extract with the auxiliary materials, applying the extract to a leaf-proof ring of a blank plaster and covering an anti-sticking layer to form the traditional Chinese medicine navel plaster. The traditional Chinese medicine navel plaster improves a digestive function, regulates water metabolism, eliminates gastrointestinal smooth muscle spasm, accordingly stops the diarrhea and pain, is used for treating the infantile diarrhea and is good in treatment effect, high in curative ratio, free from toxic and side effects and convenient to use.

The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, alleviating contraction or spasm of gastrointestinal smooth muscle to facilitate a diagnostic medical procedure and treating or preventing a gastrointestinal disorder using the compositions of the invention.

The invention relates to an alpine-yarrow-herb compound oral preparation and an application. The oral preparation is prepared from alpine yarrow herbs, smilax china, gallnuts, cuttlebones, coriander seeds, corals and fennelflower seeds. The alpine-yarrow-herb compound oral preparation has the obvious promoting effect on the rat in-vitro gastrointestinal smooth muscle contractile activity, has the obvious protective effect on the rat reflux esophagitis mucosa, has the obvious inhibiting effect on acute inflammation caused by mouse ear swelling induced by dimethylbenzene, subacute inflammation caused by rat toe swelling induced by carrageenan, chronic inflammation caused by rat cotton pellet granuloma and generation of inflammation mediator PGE2, and has the neutralization effect on acid indigestion. Clinical researching and experimental researching show that the alpine-yarrow-herb compound oral preparation is capable of removing local abnormal biliary fluid and blood stasis, astringing and inducing astringency, promoting digestion and descending qi, and has the remarkable treating effect on reflux esophagitis and gastritis.

The present invention discloses one kind of compound Chinese medicine preparation for treating gastrointestinal tract diseases of farm animal and its preparation process and application. The compound Chinese medicine preparation is prepared with fenugreek trigonella in 60-70 wt% and poppy leaf and stem in 30-40 wt%. The preparation process includes collecting and treating the above-ground part of fenugreek trigonella and poppy leaf and stem, and mixing and packing. The compound Chinese medicine preparation has low cost and the functions of relieving pain, inhibiting intestinal activity, relaxing gastrointestinal smooth muscle and stopping diarrhea to prevent and treat gastrointestinal tract diseases of farm animal effectively.

The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.

The invention discloses a preparation formula of a fruit pizza. The fruit pizza is prepared from flour, yeast powder, olive oil, white sugar, water, milk, tomato sauce, cheese, salad rice, cinnamon powder and a fruit. The fruit pizza has the beneficial effects that the olive oil is natural juice oil. can lower the content of low-density lipoprotein cholesterol and increase high-density lipoproteincholesterol after long-term use, and is more conducive to health; the cinnamon powder has four functions of aroma attracting, drug health care, feed mold prevention, and growth promotion, has strongantibacterial activity, has a strong bactericidal effect on Staphylococcus, Escherichia coli, Shigella dysenteriae, Streptococcus, Salmonella enteritidis, Vibrio cholerae and the like, has the effectsof resisting influenza virus, appetizing, tonifying spleen and benefiting qi, has a mild stimulating effect on the gastrointestinal tract, can promote the secretion of digestive juice, excite the gastrointestinal smooth muscle, accelerate the gastrointestinal motility, improve the function of the intestinal mucosa, promote the absorption of nutrients, and eliminate the accumulation of gas in theintestine.

The invention discloses traditional Chinese medicine powder capable of promoting gastrointestinal motility, wherein the components in the formula comprise 1-15 parts of clove, 1-16 parts of tetradium ruticarpum, 1-10 parts of cinnamomum cassia presl, 1-8 parts of borneol, 5-15 parts of gardenia jasminoides var.grandiflora, and 10-30 parts of agrimonia pilosa ledeb. According to the present invention, the traditional Chinese medicine powder can promote the gastrointestinal smooth muscle peristalsis, improve the intestinal blood circulation, reduce the blood capillary permeability, and protect the intestinal mucosal barrier and reduce the bacterial translocation so as to eliminate inflammations; the traditional Chinese medicine powder has advantages of effective inflammatory reaction reducing, clinical symptom improving, and treatment cycle shortening; and the traditional Chinese medicine powder further can reduce the stimulation of the drug on the gastrointestinal tract, can significantly improve the drug absorption, has characteristics of high absorption rate, rapid efficacy providing, rapid effect, low adverse reaction, good body tolerance and the like, and is suitable for clinical promotion and application.

The invention discloses an application of a peach blossom and an extract of the peach blossom in preparing drugs for treating the fatty liver, digestive juice parasecretion and gastrointestinal motility disorder. Experiments prove that the peach blossom and the extract of the peach blossom can promote contraction and peristalsis of a gastrointestinal smooth muscle, secretion of gastric juice, bile, pancreatic juice and intestinal juice, obviously relieves the experimental fatty liver in an animal, and has no obvious effect on histomorphology and functions of vital organs or systems such as a heart, a lung, a liver, a kidney, a brain, immunity, hematopoiesis, reproduction, blood coagulation and a gastrointestinal tract.

The invention relates to a medicine for treating stomach diseases, more specifically a traditional Tibetan medicine pill for strengthening the spleen and stomach. The medicine for treating stomach diseases is prepared from the following active pharmaceutical ingredients: myrobalam, tsaoko, calcite, travertine, pterocephalus hookeri heck, nutmeg, Herpetospermum pedunculosum, clove, safflower, pomegranate, costus root, pawpaw, honey, agilawood, Saxifrage, Zhaxun and cardamom. A preparation method comprises the following steps: pretreating raw materials, processing the medicines, pulverizing, sterilizing, screening, mixing, making into pills, baking, polishing, packaging and warehousing. The invention has the effects of strengthening the spleen and stomach, relieving pain, preventing or arresting vomiting, separating clear and excreting turbid, quickly reliving the spasm of the gastrointestinal smooth muscles, and improving the gastrointestinal functions so as to alleviate pain, eliminate gasterectasis, and belching and the like; and the invention can effectively kill Helicobacter pylori, resist inflammation, soothe the gastric acid, form a gastric mucosa protective shield, enhance the gastric mucosa blood flow and promote the restoration of the gastric mucosa, thereby thoroughly relieving the diseases. The invention has the advantages of quick effect taking, favorable curative effect, short treatment course, no side effect and high safety and reliability, is convenient to use, is a branded product of Tianzhu Traditional Tibetan Medicine, and is well welcomed by massive people and patients.

The invention relates to an amino-containing cellulose grafted copolymer ( represented by formula (I)), a preparation method and an application of the copolymer, as well as a compound containing the copolymer. In the formula I, R1, R2 and R3 are the same as or different from each other, each is selected from H, CH3, -COOH, -CH2OH, -CH2CH2OH and / or -CH2CH(CH3)OH, respectively, one in R1, R2 and R3 is -CH3 when the other two are different, or one in R1, R2 and R3 is -COOH when the other two are different; R4 is H or CH3; R5 is the group containing amino; n is the degree of polymerization of cellulose of the main chain structural unit of the copolymer, and the value of n is determined according to the used cellulose derivative. The cellulose copolymer provided by the invention is capable of regulating gastrointestinal smooth muscle, unlikely to be degraded by gastrointestinal enzymes, and absorbed less or un-absorbed, so that not only the initial treating effect is held but also the gastrointestinal part is regulated, and thus the side effect is minimized.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine navel paste for treating infantile diarrhea. The traditional Chinese medicine navel paste is prepared from the following medicinal raw materials: root of lobed kudzuvine, liquorice root, immature bitter orange, Chinese thorowax root, white peony root, coptis chinensis, medicated leaven, scorched hawthorn fruit, common ginger, medicinal evodia fruit, clove, cassia bark, costustoot, Indian buead, tuber fleeceflower stem and hirsute shiny bugleweed herb. According to the traditional Chinese medicine navel paste disclosed by the invention, a conventional treatment method for only treating symptoms of diarrhea without treating the root causes can be broken, various medicines are adopted, the digestive functions can be improved, the body fluid metabolism can be regulated, the yin and yang equilibrium can be corrected, the gastrointestinal smooth muscle spasm can be relieved, and thus the purposes of stopping diarrhea and relieving pain can be achieved; and the traditional Chinese medicine navel paste has the advantages of good curative effect, high cure rate, no toxic or side effects and convenience in use in the treatment of infantile diarrhea.

The invention discloses a dual-wavelength high-uniformity high-energy spectrum treatment device, and relates to the field of treatment devices. The device comprises an infrared treatment device main body. A cable gathering groove can receive infrared light emitted by an infrared lamp, gathers the infrared light into a reinforcing groove, refracts the infrared light back and forth through the smooth light reflecting surface on the inner wall of the reinforcing groove and finally irradiates the infrared light through an irradiation hole, so that the infrared light gathering groove plays a role in gathering the infrared light, the infrared light is uniformly irradiated on the surface of the skin and the like through a plurality of groups of irradiation holes for the purpose of treatment, the infrared lamp can emit the infrared light with the optical power density and the photochemical treatment effect, the skin and subcutaneous tissues convert the absorbed infrared energy into heat, and the heat effect is the main action mechanism of an infrared treatment product, and causes vasodilatation, blood flow acceleration, local blood circulation improvement and tissue nutrition metabolism enhancement, so that the muscular tension of skeletal muscle is reduced, the gastrointestinal smooth muscle is relaxed, and the muscle spasm is relieved.