35 results about "Gastrointestinal smooth muscle" patented technology

The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, alleviating contraction or spasm of gastrointestinal smooth muscle to facilitate a diagnostic medical procedure and treating or preventing a gastrointestinal disorder using the compositions of the invention.

The invention relates to an alpine-yarrow-herb compound oral preparation and an application. The oral preparation is prepared from alpine yarrow herbs, smilax china, gallnuts, cuttlebones, coriander seeds, corals and fennelflower seeds. The alpine-yarrow-herb compound oral preparation has the obvious promoting effect on the rat in-vitro gastrointestinal smooth muscle contractile activity, has the obvious protective effect on the rat reflux esophagitis mucosa, has the obvious inhibiting effect on acute inflammation caused by mouse ear swelling induced by dimethylbenzene, subacute inflammation caused by rat toe swelling induced by carrageenan, chronic inflammation caused by rat cotton pellet granuloma and generation of inflammation mediator PGE2, and has the neutralization effect on acid indigestion. Clinical researching and experimental researching show that the alpine-yarrow-herb compound oral preparation is capable of removing local abnormal biliary fluid and blood stasis, astringing and inducing astringency, promoting digestion and descending qi, and has the remarkable treating effect on reflux esophagitis and gastritis.

The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.

This scheme discloses the new use of bibenzyl compounds, specifically relates to the application of bibenzyl compounds in the preparation of drugs for promoting gastrointestinal motility. In the present invention, 4,3'-dihydroxy-3,5'-dimethoxybibenzyl was carried out in vivo animal experiments, mainly based on the gastrointestinal peristalsis activity experiment of the zebrafish model, and found that it can act on the cholinergic nervous system , stimulate M receptors, thereby enhancing the excitability of gastrointestinal smooth muscle, increasing the amplitude and frequency of gastrointestinal motility, effectively promoting gastrointestinal motility, and facilitating gastrointestinal emptying. Digestive and M-receptor agonist drugs.

The invention discloses an application of a peach blossom and an extract of the peach blossom in preparing drugs for treating the fatty liver, digestive juice parasecretion and gastrointestinal motility disorder. Experiments prove that the peach blossom and the extract of the peach blossom can promote contraction and peristalsis of a gastrointestinal smooth muscle, secretion of gastric juice, bile, pancreatic juice and intestinal juice, obviously relieves the experimental fatty liver in an animal, and has no obvious effect on histomorphology and functions of vital organs or systems such as a heart, a lung, a liver, a kidney, a brain, immunity, hematopoiesis, reproduction, blood coagulation and a gastrointestinal tract.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine navel paste for treating infantile diarrhea. The traditional Chinese medicine navel paste is prepared from the following medicinal raw materials: root of lobed kudzuvine, liquorice root, immature bitter orange, Chinese thorowax root, white peony root, coptis chinensis, medicated leaven, scorched hawthorn fruit, common ginger, medicinal evodia fruit, clove, cassia bark, costustoot, Indian buead, tuber fleeceflower stem and hirsute shiny bugleweed herb. According to the traditional Chinese medicine navel paste disclosed by the invention, a conventional treatment method for only treating symptoms of diarrhea without treating the root causes can be broken, various medicines are adopted, the digestive functions can be improved, the body fluid metabolism can be regulated, the yin and yang equilibrium can be corrected, the gastrointestinal smooth muscle spasm can be relieved, and thus the purposes of stopping diarrhea and relieving pain can be achieved; and the traditional Chinese medicine navel paste has the advantages of good curative effect, high cure rate, no toxic or side effects and convenience in use in the treatment of infantile diarrhea.