527 results about "Bactericidal effect" patented technology

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention discloses a porphyrin-based covalent organic framework nano material, a preparation method and application of the porphyrin-based covalent organic framework nano material in polyurethane, and belongs to the field of functional nano materials and antibacterial materials. The porphyrinyl covalent organic framework nano material is prepared from 5, 10, 15, 20-tetra (4-aminophenyl) porphyrin and bis-(5-formyl furfuryl) ether through a Schiff base reaction, and the structural formula of the porphyrinyl covalent organic framework nano material is # imgabs0. The porphyrinyl covalent organic framework nano material prepared by the invention has relatively high photothermal conversion efficiency when being used as a photothermal agent, and has a relatively good sterilization effect under the condition of relatively low concentration. Besides, based on the porphyrin-based covalent organic framework nano material, a WPUS / Por-COF composite film is prepared, the composite film has excellent mechanical properties and excellent photothermal conversion efficiency, and has a good sterilization effect under the condition of relatively low concentration, bacteria can be inactivated within a short time, and the sterilization rate can reach 99% or above.

The invention provides a thiazolidinone compound and application thereof in preparation of drugs for resisting staphylococcus aureus infection. The molecular structural formula of the thiazolidinone compound is shown as a formula (1), a formula (2), a formula (3) or a formula (4). The technical scheme of the invention discloses several thiazolidinone compounds, which not only have an excellent bactericidal effect on staphylococcus aureus and can significantly inhibit the formation of a biofilm of staphylococcus aureus, but also have low cytotoxicity and hemolytic activity. According to the technical scheme, a certain foundation is laid for research and development of novel staphylococcus aureus biofilm infection resisting drugs, and the potential of thiazolidone derivatives for developing novel antibacterial agents for staphylococcus aureus related infection can be deeply known possibly.

The invention provides an additive composition containing a bioactive enzyme and a preparation method of the additive composition, and belongs to the technical field of biological enzymes. The preparation method comprises the following steps: fixing phytic acid and cyclodextrin on hydroxyapatite, modifying with tannic acid, reacting with dithiothreitol modified lysozyme to prepare an immobilized compound, adding 2, 2-dimethoxy-2-phenylacetophenone and methyl methacrylate, and carrying out irradiation reaction with an ultraviolet lamp to prepare the additive composition containing the bioactive enzyme. The broad-spectrum antibacterial property and the antiviral property of the lysozyme are greatly improved, the sterilization effect on gram negative bacteria is obviously improved, meanwhile, the stability of enzyme is greatly improved, the enzyme is not prone to inactivation, the preservation time of the enzyme is prolonged, the application effect of the enzyme is widened, meanwhile, the lysozyme has good killing capacity on oral bacteria and viruses, the addition of preservatives is reduced, and the cost is reduced. The cleaning effect and stability of the product are improved, tooth demineralization can be prevented, decayed teeth can be prevented, and wide application prospects are achieved.

The invention relates to a biological long-acting bactericide and a preparation method and application thereof.The biological long-acting bactericide can release a quaternary ammonium salt type sophorolipid sterilization unit with the sterilization effect according to needs, the sterilization time is effectively prolonged, the recycling performance of the bactericide is improved, and the biotoxicity of the bactericide is reduced; the excessive use of the bactericide is avoided to a great extent; in addition, the biological long-acting bactericide also has excellent substrate adhesion and washing resistance, and is beneficial to inhibition of adhesion of bacteria on the surface of a material, so that the surface of the material washed by water still keeps relatively high antibacterial ability.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide Mh-GC21 as well as a precursor and application thereof. The amino acid sequence of the antibacterial peptide Mh-GC21 provided by the invention is as shown in SEQ ID NO.1, and two cysteines are oxidized to form a pair of intermolecular disulfide bonds; the C tail end of the antibacterial peptide Mh-GC21 is subjected to amidation modification. The antibacterial peptide Mh-GC21 provided by the invention is from microhyla microcarpa, has broad-spectrum antibacterial activity, has relatively good antibacterial and bactericidal effects on standard strains of acinetobacter baumannii, escherichia coli and staphylococcus aureus and clinically sourced drug-resistant strains, and can be used for targeted destruction of cell membranes of bacteria, removal of biological membranes and inhibition of formation of the biological membranes. Moreover, the antibacterial peptide Mh-GC21 has the advantages of good stability, no hemolytic activity and cytotoxicity, and difficulty in inducing strains to generate drug resistance.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an LL-37 derived antibacterial peptide and application thereof. According to the invention, 17-29aa of the LL-37 antibacterial peptide is used as a core fragment and is connected with an amino acid sequence shown as SEQ ID NO: 1 or SEQ ID NO: 2 through an amido bond, the antibacterial activity of the obtained antibacterial peptide is obviously higher than that of the LL-37 antibacterial peptide, and the antibacterial peptide shows an obvious bactericidal effect on clinical drug-resistant bacteria such as acinetobacter baumannii, pseudomonas aeruginosa, escherichia coli, staphylococcus aureus, klebsiella pneumoniae and the like; meanwhile, the cytotoxicity and hemolytic activity are weak, drug resistance is not prone to being generated, bacteria can be rapidly killed in vivo through multiple mechanisms, no obvious cytotoxicity exists, the bacterium load in tissue is remarkably reduced, and the lifetime of a bacterium-infected mouse is prolonged.

The invention provides engineering lyase Art-15 with broad-spectrum antibacterial activity, antibacterial peptide NZ2114 and bacteriophage lyase PlySs2 are subjected to functional fusion through an optimally designed flexible linker, and an efficient bactericidal effect on Staphylococcus aureus (Staphylococcus aureus) and Streptococcus spp.) is achieved. The engineering lyase Art-15 has the advantages that the engineering lyase Art-15 has broad-spectrum antibacterial activity, the antibacterial peptide NZ2114 and the bacteriophage lyase PlySs2 are subjected to functional fusion through the optimally designed flexible linker, and the engineering lyase Art-15 has broad-spectrum antibacterial activity; the lyase Art-15 overcomes the defects of narrow host spectrum and insufficient splitting activity of the lyase through a synergistic destruction mechanism of targeting bacterial cell wall peptidoglycan. Experiments show that the minimal inhibitory concentration (MIC) of the lyase Art-15 on staphylococcus aureus in vitro is lower than 2 mu g / mL, the minimal inhibitory concentration of the lyase Art-15 on streptococcus agalactiae is lower than 1 mu g / mL, the minimal inhibitory concentration of the lyase Art-15 on streptococcus dysgalactiae is lower than 2 mu g / mL, and the sterilization rate of the lyase Art-15 can reach 97% or above within 30 minutes by 2 times of MIC. The lyase Art-15 disclosed by the invention has important application value in the fields of drug-resistant bacterium infection treatment, medical instrument disinfection and livestock breeding.

The invention provides an efficient breeding method of cremastra appendiculata, and relates to the technical field of cremastra appendiculata breeding. The efficient breeding method comprises the steps of soil preparation and land selection, strain laying, wood laying, gap filling, seed dressing, sowing, shading and management. According to the method, the specific method is adjusted, humus soil containing a compound microbial agent is adopted to fill gaps among wood, then sowing is conducted, the germination rate of seeds is increased, sawdust, perlite, coco coir, decomposed organic fertilizer, bamboo charcoal powder and pyroligneous liquor are used for seed dressing before sowing, the air permeability of a matrix is improved, seeds are prevented from being rotten due to accumulated water, and breeding of pathogenic bacteria is inhibited; the water-retaining property of the substrate is increased; and symbiotic bacteria planting and seed metabolism are promoted. The foliar fertilizer containing the garlic extracting solution, the onion leaching solution, the monopotassium phosphate, the boric acid and the urea is adopted, elements needed by growth of the rhododendron simsii are provided, the strong insecticidal and bactericidal effects are achieved, and therefore the incidence rate of diseases and pests is reduced, and the seedling survival rate and the breeding efficiency of the rhododendron simsii are improved.

The invention discloses an application of NSC348884 in preparation of an antibacterial drug, the bacteria of the NSC348884 are gram-negative bacteria or drug-resistant gram-negative bacteria, and the gram-negative bacteria are acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa or klebsiella pneumoniae; based on an antibacterial drug high-throughput screening technology, it is found from 1280 small molecule compounds that the benzimidazole compound NSC348884 has direct bacteriostasis and sterilization effects on gram-negative bacteria and drug-resistant gram-negative bacteria, and no drug resistance is generated after the benzimidazole compound NSC348884 is continuously applied for 14 days. Further research shows that NSC348884 can interfere with lipid synthesis of gram-negative bacterium cell membranes, inhibit formation of biological membranes and induce lipid metabolism disorder, so that bacteriostatic and bactericidal effects are achieved. In addition, the NSC348884 can also enhance the sensitivity of the drug-resistant bacteria to the imipenem and the polymyxin B.

The invention discloses an application of a small molecule compound DK419 in preparation of a drug for resisting staphylococcus infection, and the CAS number of the small molecule compound DK419 is 2102672-22-8; the staphylococcus comprises at least one of staphylococcus aureus, staphylococcus epidermidis, staphylococcus hominis, staphylococcus capitis and staphylococcus haemolyticus. According to the technical scheme, the novel medical application of DK419 is disclosed, DK419 has the effects of inhibiting growth of staphylococcus and killing staphylococcus aureus, the antibacterial effect is better than that of first-line antibiotic vancomycin, and the bactericidal effect is equal to that of vancomycin; the DK419 has the effect of efficiently removing a biofilm; the DK419 can play a role in resisting staphylococcus aureus infection in an in-vivo skin infection model.

The present invention relates to the technical field of phages. Provided are a KL2-type Acinetobacter baumannii phage and a screening method therefor, a phage composition and the use, and a drug. The KL2-type Acinetobacter baumannii phage is named AB_SZL2, and is deposited in the China Center for Type Culture Collection with the deposit number CCTCC NO: M20241522; or the KL2-type Acinetobacter baumannii phage is named AB_SZL3, and is deposited in the China Center for Type Culture Collection with the deposit number CCTCC NO: M20241523. The KL2-type Acinetobacter baumannii phage can accurately target KL2-type Acinetobacter baumannii, and has an efficient bactericidal effect, thereby reducing the harm of KL2-type Acinetobacter baumannii and effectively addressing the problem of the antibiotic resistance of KL2-type Acinetobacter baumannii.

The invention provides a modified antibacterial peptide, and belongs to the technical field of antibacterial peptides. The invention provides a modified antibacterial peptide. The modified antibacterial peptide comprises at least one of a first antibacterial peptide, a second antibacterial peptide, a third antibacterial peptide, a fourth antibacterial peptide, a fifth antibacterial peptide and a sixth antibacterial peptide, the amino acid sequences of the first antibacterial peptide, the second antibacterial peptide, the third antibacterial peptide, the fourth antibacterial peptide, the fifth antibacterial peptide and the sixth antibacterial peptide are shown as SEQ ID NO.1-SEQ ID NO.6 in sequence. On the basis of prevotelin-2, the modified antibacterial peptide is obtained by reducing negative charge amino acid, increasing positive charge amino acid, introducing hydrophobic amino acid, adjusting or deleting an amino acid sequence and optimizing a polypeptide structure. In-vitro minimum inhibitory concentration determination results show that compared with an initial peptide, the modified antibacterial peptide has significantly enhanced antibacterial activity on bacteria and fungi, and also has an obvious bactericidal effect on clinical drug-resistant bacteria.

The invention provides an aeromonas hydrophila bacteriophage vBAhM7 and application thereof, and belongs to the technical field of microorganisms. According to the invention, aeromonas hydrophila is taken as host bacteria, a bacteriophage vBAhM7 is separated from sewage at a water inlet of a sewage treatment plant, and the titer can reach 109 PFU / mL; the tolerable temperature is 30-70 DEG C, and the high-temperature-resistant property is good; when the pH value is 3-12, the activity is relatively high, and the acid-base tolerance is good; the bacteriophage is not sensitive to chloroform, has no lipid coating on the shell, is stable in structure, and can resist the damage of organic solvents; the inhibition rate range on the host bacteria biofilm is 36.0%-68.6%, and good host bacteria biofilm inhibition capability is achieved; the in-vitro sterilization effect on host bacteria is good, and a relatively strong inhibition effect is achieved; the zebra fish can be protected; the antibacterial agent can be used for preventing and controlling aeromonas hydrophila in aquatic products, and the use of antibacterial agents in aquaculture is avoided or reduced.

The invention relates to the technical field of sewage treatment, in particular to a preparation method of a degradable bactericide for an oil field. According to the invention, a hydroxypropyl guanidine gum-polycaprolactone-ethylenediamine fragment copolymer is taken as a carrier, a methylisothiazolinone quaternary ammonium salt (Q-MIT) bactericide is loaded, and the degradable bactericide for the oil field is obtained by cooperating with a dodecyl ethyl sulfide (TC-SE) bactericide and combining with sodium polyaspartate. A carrier forms a hydrogen bond with a polar group on the surface of a biological membrane through a hydroxypropyl guanidine gum main chain to realize targeted anchoring, a polycaprolactone branched chain encapsulates Q-MIT through a hydrophobic effect, primary amino groups of ethylenediamine are introduced to form a pH sensitive Schiff base bond with Q-MIT, and the primary amino groups and adipic dihydrazide form a thermal response hydrazide bond to construct a dual dynamic covalent bond, so that controlled release of Q-MIT is realized, and the biomembrane is prepared. And moreover, the components of the whole system are connected through degradable chemical bonds, so that the environmental protection property and sustainability of oil field operation are guaranteed.

The invention belongs to the technical field of polypeptide drugs in biochemistry, and discloses three antibacterial peptide analogues as well as a preparation method and application thereof, the sequence of an antibacterial peptide P-1 is CH3CO-GGGENIKKILSKIKLLK-NH2, the sequence of an antibacterial peptide P-2 is CH3CH2CH2CO-GGGENIKKILSKIKLLK-NH2, the sequence of an antibacterial peptide P-3 is CH3 (CH2) 6CO-GGGENIKKILSKIKLLK-NH2, the carboxyl ends of polypeptides are subjected to amidation, and the polypeptides are all positively charged when the pH is equal to 7. The artificially synthesized antibacterial peptide disclosed by the invention shows a remarkable sterilization effect on multidrug resistant staphylococcus epidermidis. P-1, P-2 and P-3 have small molecular weight, are convenient to synthesize, have broad-spectrum bactericidal activity, are self-assembled into nanoparticles, have low cytotoxicity, resist trypsin degradation and the like, and have wide application prospects.

The invention belongs to the technical field of pesticide preparations, and particularly relates to kresoxim-methyl drug-loaded microspheres as well as a preparation method and application thereof. The 9% pyraclostrobin drug-loaded microspheres (Pyr (at) COzein) are prepared by modifying a Zein-pesticide emulsifier 500 # complex with n-caprylic alcohol, and the n-caprylic alcohol has a synergistic effect on pyraclostrobin, so that not only can the defect of a sustained and controlled release preparation in the aspect of fast-acting sterilization be made up, but also the use dosage of pyraclostrobin can be reduced, the risk of pesticide residue can be reduced, and the drug-loaded microspheres have a good application prospect. The ecological safety is improved.

The invention relates to the technical field of protective films, and discloses a mobile phone protective film and a preparation method thereof. Modified graphene oxide is used as a filler, a modified waterborne polyurethane emulsion is used as a film forming substance, a flatting agent and a defoaming agent are used as auxiliary materials, a waterborne polyurethane coating is prepared, the surface of a PET base material is coated with the waterborne polyurethane coating, then drying is conducted, and the mobile phone protection film is obtained. A quaternary ammonium salt group and negative charges on a bacterial cell membrane generate electrostatic attraction, so that the original structure and function of the cell membrane are destroyed, and a bactericidal effect is achieved; silanol groups generated by hydrolysis of silane groups can react with hydroxyl groups and carboxyl groups on the surface of a PET base material, so that the interface bonding force between the coating and the base material is improved; nitrogen atoms in pyrrolidone groups form hydrogen bonds with hydroxyl groups and carboxyl groups on the surface of a base material, so that the bonding strength of the coating and the base material is further improved; the adamantyl group is grafted into the graphene oxide, so that the supporting effect of the graphene oxide on the waterborne polyurethane is enhanced, and the mechanical property of the mobile phone protective film is improved.

The invention discloses identification and application of a mycobacterium tuberculosis bacteriophage susceptibility gene, and a gene target which affects mycobacterium bacteriophage infection efficiency is obtained through combined application of a mycobacterium tuberculosis CRISPR-KO library and a CRISPRi library and bacteriophage D29 infection screening. Reagents or drugs targeting phage susceptibility genes or encoded proteins thereof are screened based on the gene targets, and the reagents or drugs can knock out the phage susceptibility genes or inhibit expression of the phage susceptibility genes, or inhibit activity of the encoded proteins of the phage susceptibility genes, serve as phage synergists, or are combined with antibiotics to be used with phages, and can be used for preparing drugs for treating the phage susceptibility genes or the encoded proteins of the phage susceptibility genes. The bacteriophage-antibiotic composition has the advantages that a synergistic sterilization effect is achieved, a new strategy is provided for bacteriophage-antibiotic combined treatment of drug-resistant mycobacterium infection, rapid sterilization is expected to be achieved, the treatment course is shortened, and finally the target of rapid treatment of tuberculosis and other pathogenic mycobacterium infection is achieved.

The invention provides a tobacco leaf nitrogen efficient sesame cake fertilizer and a preparation method thereof, and relates to the field of fertilizers. The nitrogen efficient sesame cake fertilizer for tobacco leaves comprises a solid material and water, the solid material comprises the following raw materials in percentage by mass: 60%-70% of sesame cake, 6%-8% of cottonseed cake, 12%-26% of rice husk and 8%-10% of polyaspartic acid, wherein the total mass of the raw materials is 100%. The nitrogen efficient sesame cake fertilizer for the tobacco leaves can effectively improve the quality of the tobacco leaves, improve the growth vigor of the tobacco leaves and improve the hacking degree of flue-cured tobacco leaves to a certain extent, and the cottonseed cake is added due to the fact that gossypol with a bactericidal effect is contained in the cottonseed cake, and the occurrence of soil diseases can be relieved or inhibited.

The invention discloses a copper-doped cerium oxide antifouling agent and a preparation method and application thereof.The antifouling agent takes cerium oxide as a main body material, copper is introduced for doping, Cu < 2 + > partially replaces Ce < 4 + > to enter crystal lattices, charge imbalance is caused, more oxygen vacancies are induced to be generated, meanwhile, reduction conversion from Ce < 4 + > to Ce < 3 + > is promoted, and formation of the oxygen vacancies is further stabilized. The oxygen vacancies obviously enhance the surface catalytic activity of the material, H2O2 and Br <-> in seawater can be efficiently catalyzed to generate hypobromous acid (HOBr) with a bactericidal effect, the function of natural halogenated peroxidase is simulated, and long-acting and environment-friendly biological antifouling is realized. The antifouling agent provided by the invention can be synthesized by adopting a hydrothermal method, is simple and convenient in process, is suitable for large-scale preparation, is suitable for various marine environment antifouling scenes such as hulls, marine engineering equipment and underwater sensors, and has a good application prospect.

The invention provides a compound as shown in a formula (I), a stereoisomer thereof, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a crystal form thereof, an isotope derivative thereof, a prodrug thereof and a metabolite thereof. The solvate or hydrate of the compound can be used for preparing a pharmaceutical composition for treating and / or preventing diseases related to mycobacterium tuberculosis and / or nontuberculous mycobacterium. The compound provided by the invention has an excellent bactericidal effect and strong specificity, has no cross resistance with the existing antituberculosis drugs, and provides a breakthrough direction for treatment of drug-resistant tuberculosis.

The invention provides a discharging device and sterilization equipment, the discharging device comprises a first voltage part and a second voltage part, an interval channel is arranged between the first voltage part and the second voltage part, the first voltage part is provided with a plurality of air inlets penetrating through the two sides of the first voltage part, and the second voltage part is provided with a plurality of air outlets penetrating through the two sides of the second voltage part; air enters the interval channel from one side of the first voltage piece through the air inlet hole, is ionized and then flows out through the air outlet hole. Air is ionized in the interval channel between the first voltage part and the second voltage part to form gas-phase active particles and free radicals with strong oxidizing property, and the gas-phase active particles and free radicals can destroy cell membranes, enzyme systems and genetic materials of microorganisms, so that the microorganisms in the space are efficiently killed, and the safety of the space is improved. Therefore, a relatively strong bacteriostatic and bactericidal effect is achieved; meanwhile, in the sterilization and bacteriostasis process of the discharging device, toxic substances harmful to the human body cannot be generated, the green and harmless sterilization effect is achieved, and man-machine coexistence is achieved.

The invention discloses an antibacterial peptide PA targeting multi-drug-resistant gram-negative bacteria and application of the antibacterial peptide PA, and the amino acid sequence of the antibacterial peptide PA is shown as SEQ ID NO.1. The antibacterial peptide PA provided by the invention has a remarkable antibacterial effect of the multi-drug-resistant gram-negative bacteria, is quick in bactericidal effect, does not have hemolysis and cytotoxicity, does not cause renal toxicity after treatment, and can be used for preparing the antibacterial peptide PA for treating the multi-drug-resistant gram-negative bacteria. The biological safety is good, and the compound can be used for treating bacterial infection and can also be applied to other scenes needing sterilization or bacterial growth inhibition.

The invention discloses a preparation method of plasma activated hydrogel, the method is based on a plasma device, the plasma device comprises a plasma pretreatment assembly, a plasma activation assembly and a monitoring control assembly, the preparation method comprises the following steps: adding hydrogel into a pretreatment chamber, generating plasmas by a first plasma generator, conveying the plasmas to the pretreatment chamber to perform oxidation pretreatment on the hydrogel, dropwise adding an alkaline solution into the hydrogel subjected to the plasma oxidation pretreatment to perform neutralization reaction, and performing vacuum freeze drying on the neutralized hydrogel at the temperature of 60 DEG C below zero to 80 DEG C below zero; the freeze-dried hydrogel is subjected to swelling and activating treatment through a plasma activating assembly, and the plasma activated hydrogel is obtained. By adopting the method to prepare the plasma activated hydrogel, efficient loading of plasma active particles can be realized, and the sterilizing effect of the plasma activated hydrogel is improved.

The invention discloses preparation of an antibacterial copper-based nano-enzyme fiber dressing capable of promoting wound healing, and belongs to the technical field of medical use. According to the method, 5, 6-dimethylbenzimidazole and copper salt are used as raw materials, the copper-based nano-enzyme is synthesized through a hot bath reaction method of a solvent, reactants are uniformly dispersed in a solution, and the defects that traditional nano-enzyme element components are not uniform, and active sites are low in density are overcome. The prepared copper-based nano enzyme has a unique metal active center, and has oxidase-like activity, catalase-like activity and superoxide dismutase-like activity. According to the copper-based nano-enzyme Cu-NPs II, the activity of oxidase can be achieved without hydrogen peroxide, active oxygen can be generated to achieve the bactericidal effect, when excessive ROS is generated, superoxide dismutase-like activity of the copper-based nano-enzyme Cu-NPs II converts the excessive ROS into H2O2, and due to the fact that the copper-based nano-enzyme Cu-NPs II has catalase-like activity and can decompose H2O2 into water and oxygen, the copper-based nano-enzyme Cu-NPs II has good microenvironment adjusting capacity.

The invention relates to an antibacterial peptide LK-KJT-B01 for gram-negative bacterium infection and a preparation method and application thereof.The antibacterial peptide LK-KJT-B01 can be extracted from bacillus laterosporus, has the advantages of being broad in spectrum, safe, free of toxicity and the like, has a very strong bactericidal effect on gram-negative bacterium infection, and can be used for preparing antibacterial peptide LK-KJT-B01 for gram-negative bacterium infection. Particularly, the sensitivity to carbapenem-resistant gram-negative bacteria is high, and the application prospect is very wide.

The invention relates to a high-elastic antibacterial modified chinlon fabric and a preparation method thereof. The high-elastic antibacterial modified chinlon fabric comprises 90-95 parts by weight of a chinlon fabric and 5-10 parts by weight of a composite modifier, wherein the composite modifier comprises nano cellulose, amino polyethylene glycol carboxyl and an antibacterial agent; the nano cellulose accounts for 40-60% of the weight of the composite modifier; the weight of the amino polyethylene glycol carboxyl accounts for 20-40% of the weight of the composite modifier; the antibacterial agent accounts for 10-30% of the weight of the composite modifier. In the composite modifier, the nano cellulose and amino polyethylene glycol carboxyl form a uniform modified layer on the surface of the fiber to enhance the elasticity and toughness of the fiber, the antibacterial agent is added into the modifier, and the adsorption effect of the nano cellulose is combined with the bactericidal effect of the antibacterial agent to form a dual antibacterial mechanism, so that the antibacterial property of the fiber is improved. The antibacterial performance of the fiber is remarkably improved, so that the high requirements of underwear such as underpants on materials can be better met.

The invention discloses a composition for preventing and treating mastitis and its preparation method and application, including the following components in parts by mass: 10-12 parts of aloe gel, 3-5 parts of berberine tannate and 2-4 parts of gentiana macrophylla extract. The aloe gel and the gentiana macrophylla extract in the present composition are both plant extract ingredients, and both have anti-inflammatory and bactericidal effects. Berberine tannate is a kind of alkaloid, has significant antibacterial effect, and the three are compounded, and the use of antibiotics can be effectively reduced, thereby reducing the residual of antibiotics in animal products, and increasing the safety of product; in addition, aloe gel, gentiana macrophylla extract and berberine tannate have synergistic synergistic effect, and the three are compounded, and mastitis can be effectively treated.

Provided are an antibacterial and deodorizing composition and a functional core prepared from the composition. The antibacterial and deodorizing composition comprises the following components in parts by mass: 10%-30% of a wormwood extract, 5%-30% of a grapefruit extract, 5%-20% of a haematococcus pluvialis extract, 5%-20% of citronellyl methylcrotonate, and the balance of a solvent. The antibacterial and deodorizing composition disclosed in the present invention not only exhibits broad-spectrum antibacterial and bactericidal effects on various microorganisms and thereby prevents symptoms such as allergy, inflammation, and erythema, but also can chelate substances such as amine, ammonia gas, and hydrogen sulfide in urine and demonstrate odor-masking effect, and thereby can effectively eliminate the odor of urine.