843 results about "Bactericidal effect" patented technology

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention discloses a porphyrin-based covalent organic framework nano material, a preparation method and application of the porphyrin-based covalent organic framework nano material in polyurethane, and belongs to the field of functional nano materials and antibacterial materials. The porphyrinyl covalent organic framework nano material is prepared from 5, 10, 15, 20-tetra (4-aminophenyl) porphyrin and bis-(5-formyl furfuryl) ether through a Schiff base reaction, and the structural formula of the porphyrinyl covalent organic framework nano material is # imgabs0. The porphyrinyl covalent organic framework nano material prepared by the invention has relatively high photothermal conversion efficiency when being used as a photothermal agent, and has a relatively good sterilization effect under the condition of relatively low concentration. Besides, based on the porphyrin-based covalent organic framework nano material, a WPUS / Por-COF composite film is prepared, the composite film has excellent mechanical properties and excellent photothermal conversion efficiency, and has a good sterilization effect under the condition of relatively low concentration, bacteria can be inactivated within a short time, and the sterilization rate can reach 99% or above.

The invention discloses equipment and method for preparing double-electrolyzed water based on O3 and H2O2 in parallel, and relates to the technical field of disinfectant fluid preparation, the equipment comprises a lower shell and an upper shell, a self-priming pump, an ozone generation device, a hydrogen peroxide generation device and an ultraviolet device are installed in the lower shell, and the ozone generation device and the hydrogen peroxide generation device are arranged in parallel; a water inlet of the self-priming pump is connected with a first quick connector extending out of the side wall of the lower shell, and an outlet end of the ultraviolet device is connected with a second quick connector extending out of the side wall of the lower shell. The ozone generation device and the hydrogen peroxide generation device are connected in parallel, an aqueous solution containing ozone and hydrogen peroxide at the same time is obtained by controlling the proportion of ozone and hydrogen peroxide, photolysis of ozone and hydrogen peroxide is promoted by utilizing the synergistic effect of ozone and hydrogen peroxide and introducing an ultraviolet light source, and therefore more hydroxyl radicals are generated; and compared with an ozone solution, the sterilization effect of the disinfectant fluid is better.

The invention discloses a self-response odor-removing and sterilizing material, a preparation method thereof and a refrigerator, and belongs to the technical field of refrigerator adsorption materials. Comprising main materials and auxiliary materials, the main body material is composed of an adsorption material and a formaldehyde removal agent; the auxiliary material is composed of a response material and a bactericide; the response material is selected from a covalent organic framework; the bactericide is selected from benzimidazole compounds; the benzimidazole compound shows a deprotonation trend when the pH value is any one value of 2.8-7.1, and is combined with the covalent organic framework through electrostatic attraction; when the pH value is less than 2.8, the benzimidazole compound and the covalent organic framework are protonated at the same time, and the benzimidazole compound is released. The sterilization material is applied to the refrigerator sterilization aspect, and the problems that the sterilization effect is not lasting due to the fact that a common odor-removing sterilization material plays a role to release sterilization substances from the beginning of application, or the sterilization material cannot be actively released, the sterilization effect can be achieved only when bacteria are adsorbed on the surface of the sterilization material, and the bacteria in the air cannot be killed are solved.

The invention relates to the technical field of acrylic resin, and discloses a salt-spray-resistant epoxy modified waterborne acrylic resin emulsion as well as a preparation method and application thereof, the waterborne acrylic resin emulsion comprises 100 parts by weight of vinyl monomer, 0.4-0.5 part by weight of initiator, 2-2.8 parts by weight of emulsifier and 10-35 parts by weight of cationic Schiff base modified epoxy resin; after the epoxy resin is subjected to cationic modification, an antibacterial cationic quaternary ammonium salt group is introduced into a molecular chain, so that a very good bactericidal effect can be achieved, and the epoxy resin shows a good antibacterial rate on escherichia coli and staphylococcus aureus. The acrylic resin is endowed with excellent antibacterial performance. Meanwhile, the adhesive force, the water resistance, the salt spray resistance and the like of a paint film are improved, and the paint film shows better corrosion resistance.

The invention provides a thiazolidinone compound and application thereof in preparation of drugs for resisting staphylococcus aureus infection. The molecular structural formula of the thiazolidinone compound is shown as a formula (1), a formula (2), a formula (3) or a formula (4). The technical scheme of the invention discloses several thiazolidinone compounds, which not only have an excellent bactericidal effect on staphylococcus aureus and can significantly inhibit the formation of a biofilm of staphylococcus aureus, but also have low cytotoxicity and hemolytic activity. According to the technical scheme, a certain foundation is laid for research and development of novel staphylococcus aureus biofilm infection resisting drugs, and the potential of thiazolidone derivatives for developing novel antibacterial agents for staphylococcus aureus related infection can be deeply known possibly.

The invention provides an additive composition containing a bioactive enzyme and a preparation method of the additive composition, and belongs to the technical field of biological enzymes. The preparation method comprises the following steps: fixing phytic acid and cyclodextrin on hydroxyapatite, modifying with tannic acid, reacting with dithiothreitol modified lysozyme to prepare an immobilized compound, adding 2, 2-dimethoxy-2-phenylacetophenone and methyl methacrylate, and carrying out irradiation reaction with an ultraviolet lamp to prepare the additive composition containing the bioactive enzyme. The broad-spectrum antibacterial property and the antiviral property of the lysozyme are greatly improved, the sterilization effect on gram negative bacteria is obviously improved, meanwhile, the stability of enzyme is greatly improved, the enzyme is not prone to inactivation, the preservation time of the enzyme is prolonged, the application effect of the enzyme is widened, meanwhile, the lysozyme has good killing capacity on oral bacteria and viruses, the addition of preservatives is reduced, and the cost is reduced. The cleaning effect and stability of the product are improved, tooth demineralization can be prevented, decayed teeth can be prevented, and wide application prospects are achieved.

The invention relates to a persistent deodorization type cat litter partner as well as a preparation method and application thereof. The cat litter mate is prepared by compounding nano zinc chloride, bacillus subtilis powder and enterococcus faecium powder according to a specific proportion, and has an excellent deodorization effect. The bacillus subtilis and enterococcus faecium powder can secrete various enzymes and bacteriocin, effectively decompose odor substances and inhibit growth of putrefying bacteria, and tolerate the bactericidal effect of nano zinc chloride at the same time. The cat litter mate provided by the invention can significantly reduce the concentration of ammonia gas and volatile organic compounds, has the advantages of long-acting deodorization, environmental protection and safety, and is suitable for the field of pet breeding.

The invention relates to the technical field of nano-particles, and particularly provides a preparation method of luteolin-loaded mesoporous polydopamine nano-particles, which mainly comprises the following steps: adding mesoporous polydopamine nano-particles into a luteolin solution, stirring until luteolin is adsorbed onto mesoporous polydopamine, centrifuging, washing, and drying to obtain luteolin-loaded mesoporous polydopamine nano-particles. The luteolin-loaded mesoporous polydopamine nano-particles are obtained by adding the luteolin into the mesoporous polydopamine nano-particles; according to the luteolin-loaded mesoporous polydopamine nano-particles, the photo-thermal sterilization effect of the mesoporous polydopamine nano-particles is combined with the antibacterial effect of luteolin, so that the illumination sterilization effect at low temperature is achieved, and the luteolin-loaded mesoporous polydopamine nano-particles have an excellent antibacterial rate on staphylococcus aureus and escherichia coli.

The invention relates to a biological long-acting bactericide and a preparation method and application thereof.The biological long-acting bactericide can release a quaternary ammonium salt type sophorolipid sterilization unit with the sterilization effect according to needs, the sterilization time is effectively prolonged, the recycling performance of the bactericide is improved, and the biotoxicity of the bactericide is reduced; the excessive use of the bactericide is avoided to a great extent; in addition, the biological long-acting bactericide also has excellent substrate adhesion and washing resistance, and is beneficial to inhibition of adhesion of bacteria on the surface of a material, so that the surface of the material washed by water still keeps relatively high antibacterial ability.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide Mh-GC21 as well as a precursor and application thereof. The amino acid sequence of the antibacterial peptide Mh-GC21 provided by the invention is as shown in SEQ ID NO.1, and two cysteines are oxidized to form a pair of intermolecular disulfide bonds; the C tail end of the antibacterial peptide Mh-GC21 is subjected to amidation modification. The antibacterial peptide Mh-GC21 provided by the invention is from microhyla microcarpa, has broad-spectrum antibacterial activity, has relatively good antibacterial and bactericidal effects on standard strains of acinetobacter baumannii, escherichia coli and staphylococcus aureus and clinically sourced drug-resistant strains, and can be used for targeted destruction of cell membranes of bacteria, removal of biological membranes and inhibition of formation of the biological membranes. Moreover, the antibacterial peptide Mh-GC21 has the advantages of good stability, no hemolytic activity and cytotoxicity, and difficulty in inducing strains to generate drug resistance.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an LL-37 derived antibacterial peptide and application thereof. According to the invention, 17-29aa of the LL-37 antibacterial peptide is used as a core fragment and is connected with an amino acid sequence shown as SEQ ID NO: 1 or SEQ ID NO: 2 through an amido bond, the antibacterial activity of the obtained antibacterial peptide is obviously higher than that of the LL-37 antibacterial peptide, and the antibacterial peptide shows an obvious bactericidal effect on clinical drug-resistant bacteria such as acinetobacter baumannii, pseudomonas aeruginosa, escherichia coli, staphylococcus aureus, klebsiella pneumoniae and the like; meanwhile, the cytotoxicity and hemolytic activity are weak, drug resistance is not prone to being generated, bacteria can be rapidly killed in vivo through multiple mechanisms, no obvious cytotoxicity exists, the bacterium load in tissue is remarkably reduced, and the lifetime of a bacterium-infected mouse is prolonged.

The invention provides engineering lyase Art-15 with broad-spectrum antibacterial activity, antibacterial peptide NZ2114 and bacteriophage lyase PlySs2 are subjected to functional fusion through an optimally designed flexible linker, and an efficient bactericidal effect on Staphylococcus aureus (Staphylococcus aureus) and Streptococcus spp.) is achieved. The engineering lyase Art-15 has the advantages that the engineering lyase Art-15 has broad-spectrum antibacterial activity, the antibacterial peptide NZ2114 and the bacteriophage lyase PlySs2 are subjected to functional fusion through the optimally designed flexible linker, and the engineering lyase Art-15 has broad-spectrum antibacterial activity; the lyase Art-15 overcomes the defects of narrow host spectrum and insufficient splitting activity of the lyase through a synergistic destruction mechanism of targeting bacterial cell wall peptidoglycan. Experiments show that the minimal inhibitory concentration (MIC) of the lyase Art-15 on staphylococcus aureus in vitro is lower than 2 mu g / mL, the minimal inhibitory concentration of the lyase Art-15 on streptococcus agalactiae is lower than 1 mu g / mL, the minimal inhibitory concentration of the lyase Art-15 on streptococcus dysgalactiae is lower than 2 mu g / mL, and the sterilization rate of the lyase Art-15 can reach 97% or above within 30 minutes by 2 times of MIC. The lyase Art-15 disclosed by the invention has important application value in the fields of drug-resistant bacterium infection treatment, medical instrument disinfection and livestock breeding.

The invention relates to a deuterated pyrazolyl formamide compound as well as a preparation method and application thereof. Specifically, the compound has a structure as shown in a formula I, and has a more excellent bactericidal effect and an effect of increasing the yield. # imgabs0 #

The invention provides an efficient breeding method of cremastra appendiculata, and relates to the technical field of cremastra appendiculata breeding. The efficient breeding method comprises the steps of soil preparation and land selection, strain laying, wood laying, gap filling, seed dressing, sowing, shading and management. According to the method, the specific method is adjusted, humus soil containing a compound microbial agent is adopted to fill gaps among wood, then sowing is conducted, the germination rate of seeds is increased, sawdust, perlite, coco coir, decomposed organic fertilizer, bamboo charcoal powder and pyroligneous liquor are used for seed dressing before sowing, the air permeability of a matrix is improved, seeds are prevented from being rotten due to accumulated water, and breeding of pathogenic bacteria is inhibited; the water-retaining property of the substrate is increased; and symbiotic bacteria planting and seed metabolism are promoted. The foliar fertilizer containing the garlic extracting solution, the onion leaching solution, the monopotassium phosphate, the boric acid and the urea is adopted, elements needed by growth of the rhododendron simsii are provided, the strong insecticidal and bactericidal effects are achieved, and therefore the incidence rate of diseases and pests is reduced, and the seedling survival rate and the breeding efficiency of the rhododendron simsii are improved.

The invention belongs to the field of pesticide sterilization, and discloses a pesticide composition and application thereof. Effective components of the bactericidal composition comprise an active component A and an active component B, the active component A is a compound represented by a formula I: # imgabs0, and the active component B is any one of penflufen and sedaxane; the mass ratio of the active component A to the active component B is (1: 35)-(35: 1). The pesticide composition disclosed by the invention has a broad-spectrum bactericidal effect, the use amount and use cost of effective components are effectively reduced, and generation and development of resistance are delayed.

The invention discloses an application of NSC348884 in preparation of an antibacterial drug, the bacteria of the NSC348884 are gram-negative bacteria or drug-resistant gram-negative bacteria, and the gram-negative bacteria are acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa or klebsiella pneumoniae; based on an antibacterial drug high-throughput screening technology, it is found from 1280 small molecule compounds that the benzimidazole compound NSC348884 has direct bacteriostasis and sterilization effects on gram-negative bacteria and drug-resistant gram-negative bacteria, and no drug resistance is generated after the benzimidazole compound NSC348884 is continuously applied for 14 days. Further research shows that NSC348884 can interfere with lipid synthesis of gram-negative bacterium cell membranes, inhibit formation of biological membranes and induce lipid metabolism disorder, so that bacteriostatic and bactericidal effects are achieved. In addition, the NSC348884 can also enhance the sensitivity of the drug-resistant bacteria to the imipenem and the polymyxin B.

The present invention belongs to the field of antimicrobial peptides in biotechnology, and specifically relates to an antimicrobial peptide, a recombinant antimicrobial peptide of the antimicrobial peptide, and a preparation method and application thereof. The amino acid sequence of the antimicrobial peptide is shown in SEQ ID NO: 1, and the nucleotide sequence of the gene expressing the antimicrobial peptide is shown in SEQ ID NO: 2. A recombinant antimicrobial peptide of the antimicrobial peptide is prepared, and the antimicrobial peptide or recombinant antimicrobial peptide can be used to inhibit the growth of Streptococcus suis and exhibit a highly efficient bactericidal effect on Streptococcus suis by increasing cell membrane permeability, or to participate in the regulation of IMD and Toll pathways, or to enhance the immune defense system of Lepidoptera Sphenopteridae insects, and improve the antimicrobial ability of Lepidoptera Sphenopteridae insects. The antibodies produced by using the antimicrobial peptide or recombinant antimicrobial peptide can be used to track the above antimicrobial peptide or the above recombinant antimicrobial peptide, or to promote the expression of multiple antimicrobial peptides of insects, or to specifically recognize, bind and shield antigens.

According to the compound quaternary ammonium salt disinfectant for the sterile environment and the preparation method thereof, the benzalkonium chloride, the polyhexamethylene biguanide hydrochloride and the plant polysaccharide are compounded to form the positively charged plant polysaccharide compound disinfectant under the action of the sodium sulfite or the potassium sulfite by utilizing a compound synergistic principle, so that the compound quaternary ammonium salt disinfectant for the sterile environment is obtained. Positive charges are promoted to penetrate through cell walls of bacterial biofilms, so that an excellent bactericidal effect is achieved; the sodium hyaluronate, the enhancer and the glycerol are cooperatively used, so that sodium ions are combined with dehydrogenation groups in polysaccharide and hydroxyl groups, carboxyl groups and the like of other components to form a relatively stable internal net-shaped structure, and the situation that quaternary ammonium salt reacts with metal ions in the environment to reduce the disinfection effect is effectively avoided; meanwhile, the sodium hyaluronate and the glycerol are used for enhancing the compatibility of all the components, and the moisturizing effect of the components is fully utilized, so that the hand sanitizer is not only suitable for disinfection of object surfaces and space environments in a sterile environment, but also can be used for disinfection of hands of a human body.

The invention discloses an antibacterial peptide P1 and medical application thereof in treating sepsis. The amino acid sequence of the antibacterial peptide P1 is as shown in SEQ ID NO. 1. The antibacterial peptide P1 provided by the invention has a good treatment effect on a sepsis mouse CLP model. The antibacterial peptide P1 can play a good bactericidal effect by directly destroying cell walls and cell membranes of staphylococcus aureus; the antibacterial peptide P1 also has bacterial capture ability and immunomodulatory activity, and can relieve survival rate reduction induced by sepsis, liver and lung injury caused by sepsis, liver and lung injury caused by sepsis, and organ bacterial infection caused by sepsis. Cell walls and cell membranes of staphylococcus aureus are directly destroyed, and a network structure is formed in a hydrophobic environment to capture bacteria and promote phagocytosis of immune cells. The compound is a good novel antibiotic substitute product, and can be used for preparing drugs for treating sepsis.

The invention discloses an application of a small molecule compound DK419 in preparation of a drug for resisting staphylococcus infection, and the CAS number of the small molecule compound DK419 is 2102672-22-8; the staphylococcus comprises at least one of staphylococcus aureus, staphylococcus epidermidis, staphylococcus hominis, staphylococcus capitis and staphylococcus haemolyticus. According to the technical scheme, the novel medical application of DK419 is disclosed, DK419 has the effects of inhibiting growth of staphylococcus and killing staphylococcus aureus, the antibacterial effect is better than that of first-line antibiotic vancomycin, and the bactericidal effect is equal to that of vancomycin; the DK419 has the effect of efficiently removing a biofilm; the DK419 can play a role in resisting staphylococcus aureus infection in an in-vivo skin infection model.

The present invention relates to the technical field of phages. Provided are a KL2-type Acinetobacter baumannii phage and a screening method therefor, a phage composition and the use, and a drug. The KL2-type Acinetobacter baumannii phage is named AB_SZL2, and is deposited in the China Center for Type Culture Collection with the deposit number CCTCC NO: M20241522; or the KL2-type Acinetobacter baumannii phage is named AB_SZL3, and is deposited in the China Center for Type Culture Collection with the deposit number CCTCC NO: M20241523. The KL2-type Acinetobacter baumannii phage can accurately target KL2-type Acinetobacter baumannii, and has an efficient bactericidal effect, thereby reducing the harm of KL2-type Acinetobacter baumannii and effectively addressing the problem of the antibiotic resistance of KL2-type Acinetobacter baumannii.

The invention provides a modified antibacterial peptide, and belongs to the technical field of antibacterial peptides. The invention provides a modified antibacterial peptide. The modified antibacterial peptide comprises at least one of a first antibacterial peptide, a second antibacterial peptide, a third antibacterial peptide, a fourth antibacterial peptide, a fifth antibacterial peptide and a sixth antibacterial peptide, the amino acid sequences of the first antibacterial peptide, the second antibacterial peptide, the third antibacterial peptide, the fourth antibacterial peptide, the fifth antibacterial peptide and the sixth antibacterial peptide are shown as SEQ ID NO.1-SEQ ID NO.6 in sequence. On the basis of prevotelin-2, the modified antibacterial peptide is obtained by reducing negative charge amino acid, increasing positive charge amino acid, introducing hydrophobic amino acid, adjusting or deleting an amino acid sequence and optimizing a polypeptide structure. In-vitro minimum inhibitory concentration determination results show that compared with an initial peptide, the modified antibacterial peptide has significantly enhanced antibacterial activity on bacteria and fungi, and also has an obvious bactericidal effect on clinical drug-resistant bacteria.

The invention provides a gastrodia elata planting method capable of preventing diseases and insect pests, and belongs to the technical field of gastrodia elata planting. According to the method, plots which are high in terrain, loose in soil and good in air permeability are selected to be provided with furrows, intervals are arranged between the furrows, and spreading of germs and insect pests is avoided; according to the method, gastrodia elata is taken as a raw material, then a substrate and leaves with a bactericidal effect are laid in sequence, an antibacterial insecticide is sprayed, at the moment, germs and pests in the gastrodia elata growth process are mainly prevented and controlled, and a chemical insecticidal bactericide is utilized to play a role in preventing and controlling harmful germs and pests before gastrodia elata planting. The substrate contains antibacterial and insecticidal traditional Chinese medicine liquid and wood chips, and the wood chips can adsorb the traditional Chinese medicine liquid and have slow-release and long-acting sterilization effects, so that the effect of preventing diseases and insect pests in the gastrodia elata planting process is improved, and the yield of the gastrodia elata is increased.

The invention relates to the technical field of medical instruments, and provides a sinus tract treatment tube assembly and a sinus tract treatment device.The sinus tract treatment tube assembly comprises a tube body and a plasma generator; the catheter body comprises a catheter body and a treatment end which are connected with each other, and the treatment end is suitable for being inserted into the sinus tract; the plasma generator is arranged at the treatment end and suitable for being connected with the power module; the plasma generator comprises a negative electrode layer, a dielectric barrier layer and a positive electrode layer which are arranged in a stacked mode, or the plasma generator comprises a positive electrode and a negative electrode which are arranged in a coplanar mode. The sinus tract treatment tube assembly provided by the invention not only has drainage and flushing functions, but also has a plasma treatment function, can play a powerful bactericidal role, and promotes wound healing of a wound surface.

The invention relates to the technical field of medicines, and discloses a medicine for treating helicobacter pylori infection, which comprises the following raw materials: a substance a and pharmaceutically acceptable auxiliary materials, the structural formula of the substance a is shown as a formula (I). The substance a has a good bactericidal effect on helicobacter pylori and can be used for treating and preventing helicobacter pylori infection; and the substance a has a specific structure, can realize efficient sterilization in vivo and can be rapidly degraded at the same time, the degradation product is rapidly discharged out of the body, the substance a and the common degradation product thereof are actually nontoxic and very high in safety, and the substance a cannot be absorbed by the human body, has no side effect and cannot cause the helicobacter pylori to generate drug resistance.

The invention provides an aeromonas hydrophila bacteriophage vBAhM7 and application thereof, and belongs to the technical field of microorganisms. According to the invention, aeromonas hydrophila is taken as host bacteria, a bacteriophage vBAhM7 is separated from sewage at a water inlet of a sewage treatment plant, and the titer can reach 109 PFU / mL; the tolerable temperature is 30-70 DEG C, and the high-temperature-resistant property is good; when the pH value is 3-12, the activity is relatively high, and the acid-base tolerance is good; the bacteriophage is not sensitive to chloroform, has no lipid coating on the shell, is stable in structure, and can resist the damage of organic solvents; the inhibition rate range on the host bacteria biofilm is 36.0%-68.6%, and good host bacteria biofilm inhibition capability is achieved; the in-vitro sterilization effect on host bacteria is good, and a relatively strong inhibition effect is achieved; the zebra fish can be protected; the antibacterial agent can be used for preventing and controlling aeromonas hydrophila in aquatic products, and the use of antibacterial agents in aquaculture is avoided or reduced.

The invention relates to the technical field of sewage treatment, in particular to a preparation method of a degradable bactericide for an oil field. According to the invention, a hydroxypropyl guanidine gum-polycaprolactone-ethylenediamine fragment copolymer is taken as a carrier, a methylisothiazolinone quaternary ammonium salt (Q-MIT) bactericide is loaded, and the degradable bactericide for the oil field is obtained by cooperating with a dodecyl ethyl sulfide (TC-SE) bactericide and combining with sodium polyaspartate. A carrier forms a hydrogen bond with a polar group on the surface of a biological membrane through a hydroxypropyl guanidine gum main chain to realize targeted anchoring, a polycaprolactone branched chain encapsulates Q-MIT through a hydrophobic effect, primary amino groups of ethylenediamine are introduced to form a pH sensitive Schiff base bond with Q-MIT, and the primary amino groups and adipic dihydrazide form a thermal response hydrazide bond to construct a dual dynamic covalent bond, so that controlled release of Q-MIT is realized, and the biomembrane is prepared. And moreover, the components of the whole system are connected through degradable chemical bonds, so that the environmental protection property and sustainability of oil field operation are guaranteed.

The invention belongs to the technical field of polypeptide drugs in biochemistry, and discloses three antibacterial peptide analogues as well as a preparation method and application thereof, the sequence of an antibacterial peptide P-1 is CH3CO-GGGENIKKILSKIKLLK-NH2, the sequence of an antibacterial peptide P-2 is CH3CH2CH2CO-GGGENIKKILSKIKLLK-NH2, the sequence of an antibacterial peptide P-3 is CH3 (CH2) 6CO-GGGENIKKILSKIKLLK-NH2, the carboxyl ends of polypeptides are subjected to amidation, and the polypeptides are all positively charged when the pH is equal to 7. The artificially synthesized antibacterial peptide disclosed by the invention shows a remarkable sterilization effect on multidrug resistant staphylococcus epidermidis. P-1, P-2 and P-3 have small molecular weight, are convenient to synthesize, have broad-spectrum bactericidal activity, are self-assembled into nanoparticles, have low cytotoxicity, resist trypsin degradation and the like, and have wide application prospects.

The invention belongs to the technical field of pesticide preparations, and particularly relates to kresoxim-methyl drug-loaded microspheres as well as a preparation method and application thereof. The 9% pyraclostrobin drug-loaded microspheres (Pyr (at) COzein) are prepared by modifying a Zein-pesticide emulsifier 500 # complex with n-caprylic alcohol, and the n-caprylic alcohol has a synergistic effect on pyraclostrobin, so that not only can the defect of a sustained and controlled release preparation in the aspect of fast-acting sterilization be made up, but also the use dosage of pyraclostrobin can be reduced, the risk of pesticide residue can be reduced, and the drug-loaded microspheres have a good application prospect. The ecological safety is improved.