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111 results about "Antimikrobielle peptide" patented technology
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Amit Kessel Ph.D. Antimicrobial Peptides: A Molecular Weapon against Bacteria. fSummary. Antimicrobial peptides (AMPs) are short protein segments produced by different organisms as a defense mechanism against biological pathogens (bacteria, viruses, parasites).
Technique for preparing antimicrobial peptide by using Bacillus subtilis
InactiveCN103333937AImprove purification efficiencyImprove heat resistanceFood preservationMicroorganism based processesSide effectAntimicrobial peptides
The invention discloses a technique for preparing antimicrobial peptide by using Bacillus subtilis, belonging to the technical field of bioengineering. By using Bacillus subtilis BRT39 capable of generating broad-spectrum high-efficiency antimicrobial peptide as a production strain, liquid seed preparation, fermentation liquid preparation, fermentation liquid pretreatment, antimicrobial peptide extraction and refinement, antimicrobial peptide dry powder preparation and other techniques are carried out to prepare the high-purity antimicrobial peptide finished product, wherein the activity recovery rate is up to higher than 43.5%. The invention has the advantages of simple technique, high yield of antimicrobial peptide, and high purity; the prepared antimicrobial peptide dry powder belongs to a natural antimicrobial agent and has no toxic or side effect, and thus, can be used as a food preservative, feed additive, agricultural biological control agent or animal disease preventing agent; and the antimicrobial peptide has the advantages of no toxicity, no residue, no drug resistance and high safety.
Owner:XUZHOU UNIV OF TECH
Mass production method of antimicrobial peptide and DNA construct and expression system thereof
InactiveUS6699689B1Improve expression efficiencyBacteriaSugar derivativesAntimikrobielle peptideAnti microbial peptide
The present invention relates to DNA constructs that can produce antimicrobial materials efficiently from microorganisms and the preparation method thereof. The present invention also relates to the useful vector for the DNA construct. The DNA construct according to the present invention comprises a first gene coding for entire, a part of or a derivative of purF gene and a second gene coding for antimicrobial peptide. According to the present invention, antimicrobial peptides can be mass-produced by the following steps: preparing an expression vector containing a DNA construct comprising a first gene coding for an entire, a part of or a derivative of purF gene and a second gene coding for antimicrobial peptide; transforming the bacterial host cells with the above-mentioned vector, culturing the transformed cell to express the above-mentioned DNA construct; and recovering the above antimicrobial peptide.
Owner:SAMYANG BIOPHARMLS CORP
Albumen powder richening in antimicrobial peptide fly maggot, preparation method for albumen powder and feed additive of albumen powder
ActiveCN102894186AHigh content of active ingredientsNo pollutionAnimal feeding stuffBiotechnologyAntimikrobielle peptide
The invention discloses albumen powder richening in antimicrobial peptide fly maggot, a preparation method for the albumen powder and a feed additive of the albumen powder. The albumen powder richening in the antimicrobial peptide fly maggot is prepared by a method comprising the following steps of: (1) feeding flies, luring the flies to lay eggs and feeding larva by using feed after incubation; (2) conducting ultrasound induction on the larva; (3) continuously feeding, collecting the larva, washing, conducting disinfection treatment, and conducting tissue homogenate smashing; and (4) filtering, treating filtrate at 0-5 DEG C, removing surface lipid compositions, drying to obtain the albumen powder; adding auxiliary materials in the albumen powder, pelletizing to obtain the feed additive. A ultrasound stimulation mode under specified conditions is adopted to induce the larva to enable an antimicrobial peptide active ingredient content in a body of a housefly to obviously improve, and the feed additive has certain growth promotion and disease-resistant strengthening effects on litopenaeus vannamei, crucian and the like.
Owner:河北圣土农业科技有限公司
Comprehensive treatment method and application of insects
InactiveCN102603921AImprove reproductive performanceIncrease egg productionAnimal feeding stuffPeptide preparation methodsBiotechnologyAntimikrobielle peptide
Owner:郎影菲
Insect additive for poultry and livestock feeds and application of insect additive
InactiveCN102578390AImprove immunityImprove disease resistanceAnimal feeding stuffAccessory food factorsBiotechnologyAntimikrobielle peptide
The invention belongs to the technical field of insect feed additives, and particularly discloses an insect additive for poultry and livestock feeds and application of the insect additive. The additive comprises the following components in part by weight: 20 to 50 parts of insect albumen powder, and 1 part of chitin and antimicrobial peptide. The chitin and the antimicrobial peptide which are extracted from insects are used for compounding the additive for the feeds, and the quality of the feed is improved, so that the quality of raised animals is effectively improved, and safe and healthy meat and fish or egg products are produced.
Owner:郎影菲
Saddletail grouper antimicrobial peptide LEAP-2 gene, vector, recombinant strain and protein, and application thereof
ActiveCN103755795AEnriched gene poolReduce manufacturing costAntibacterial agentsFungiAntimikrobielle peptideImmunologic preparation
The invention discloses a Saddletail grouper antimicrobial peptide LEAP-2 gene, vector, recombinant strain and protein, and application thereof. The amino acid sequence of the Saddletail grouper antimicrobial peptide LEAP-2 precursor protein is disclosed as SEQ ID NO.2, or the Saddletail grouper antimicrobial peptide LEAP-2 precursor protein is a protein with identical or higher activity prepared by performing substitution, deletion and / or addition on one or more of amino acids and / or terminal modification on the amino acid sequence disclosed as SEQ ID NO.2. The invention also discloses a Saddletail grouper antimicrobial peptide LEAP-2 gene sequence and a LEAP-2 mature peptide gene mLEAP-2 nucleotide sequence subjected to code modification; and thus, the Saddletail grouper antimicrobial peptide LEAP-2 gene enriches the gene bank of grouper, can be used for preparing a recombinant protein, antimicrobial preparation, fish immune preparation or feed additive, and provides new theoretical and practical basis for physiologic immunity research of grouper.
Owner:SOUTH CHINA NORMAL UNIVERSITY
Antimicrobial peptide with drug-resistance bacteria resistance activity and synthesis and application thereof
The invention designs antimicrobial peptide with drug-resistance bacteria resistance activity and a novel structure. The antimicrobial peptide is obtained by modifying amino acid at N tail ends of natural antimicrobial peptide Anoplin and MPI respectively, then performing acetylization on the amino acid, and performing intermolecular connection on every two side chains of the peptide by replacing a -1H-1,2,3-triazole structure by one 1,4- under the 1,3-dipolar cycloaddition reaction of the click chemistry. The antimicrobial experiments and pyridinium iodide dyeing method experiments for staphylococcus aureus and escherichia coli of the conventional gram-positive bacterium and clinically separated drug-resistant staphylococcus aureus and drug-resistant escherichia coli show that the J-AM peptide and the J-AA peptide which are synthesized by the method are higher in antimicrobial activity, higher in drug-resistance bacteria resistance activity and higher in cytomembrane film penetration capacity and has an obvious drug-resistance advantage of avoiding a drug-resistance phenomenon caused by the general antibiotics; and therefore, the antimicrobial peptide has an extremely high application prospect in preparation of clinical treatment medicines.
Owner:LANZHOU UNIVERSITY
Pig antimicrobial peptide NK-lysin fusion protein and encoding gene and application thereof
InactiveCN104004100AReduce manufacturing costHigh economic valuePeptide/protein ingredientsHybrid peptidesAnti cancer drugsLysin
The invention belongs to the field of gene engineering in the biotechnology pharmaceuticals industry, and particularly relates to pig antimicrobial peptide NK-lysin fusion protein and an encoding gene and application thereof. The amino acid sequence of the pig antimicrobial peptide NK-lysin fusion protein is shown in SEQIDNO: 2 in the specification. The advantages of antimicrobial peptide and the advantages of Pichiapastoris are utilized in the pig antimicrobial peptide NK-lysin fusion protein very well, the encoding gene of the pig antimicrobial peptide NK-lysin fusion protein can be efficiently shown in the Pichiapastoris, and the production cost of the antimicrobial peptide is reduced. The pig antimicrobial peptide NK-lysin fusion protein is applied to preparing medicines for inhabiting tumor cells, is a superior anti-cancer drug and has very high economic value and huge social benefits.
Owner:SHANXI AGRI UNIV +1
Promotor replacement method for improving volume of production of bacillus subtilis surfactin
InactiveCN101402959AIncrease productionEasy to produceBacteriaMicrobiological testing/measurementBiotechnologyAntimikrobielle peptide
The invention relates to a promoter replacement method for improving the yield of Bacillus subtilis surfactin, belonging to the biotechnology field. The DNA homologous integration technology is adopted for allowing a promoter Pspac to replace the promoter of a Bacillus subtilis fmbR surfactin synthase gene. The homologous sequence of 1081bp is obtained by amplification from an fmbR strain genome through the PCR method and connected to HindIII and BamH I restriction enzyme cutting sites of a plasmid pMUTIN4, a well constructed vector is converted into wild Bacillus subtilis fmbR, thereby realizing the replacement through the screening by an antibiotic culture medium and the molecular biology method. The method can directly improve an antimicrobial peptide production strain on genetics, thereby having potential application value in industry. The yield of the strain surfactin is improved by about 4.85 times, and the yield of the surfactin can be improved by about 10 times under the IPTG induction.
Owner:NANJING AGRICULTURAL UNIVERSITY
Antimicrobial peptide as well as preparation method and application thereof
InactiveCN103436538ASignificantly kills root-knot nematode incognitaBiocidePlant peptidesEscherichia coliAntimikrobielle peptide
The invention discloses an antimicrobial peptide. The gene sequence of the antimicrobial peptide is a gene code sequence of a no-signal peptide of an antimicrobial peptide Snakin. The invention further discloses a method for preparing the antimicrobial peptide. The method comprises the following steps of (1) extracting the total RNA (Ribonucleic Acid) of capsicum leaf tissue, thereby obtaining a first chain cDNA (complementary Deoxyribonucleic Acid) for standby by adopting a reverse transcriptase; (2) carrying out PCR (Polymerase Chain Reaction) cloning to obtain the gene code sequence, denoted by an Sn gene sequence, of the no-signal peptide of the antimicrobial peptide Snakin; (3) forming recombination plasmids; (4) screening successfully-recombined plasmids denoted by pET-Sn; (5) transforming the successfully-recombined plasmids into competent cells BL21 (DE3) of Escherichia coli, carrying out induced expression by adopting IPTG, and meanwhile, secreting proteins; (6) carrying out ultrasonic-wave crushing on the competent cells which secrete the proteins in the step (5), carrying out centrifugation, and then, collecting the antimicrobial peptide from an supernatant. The method has the advantages that the antimicrobial peptide which does not contain signal peptides is obtained and has a killing effect on meloidogyne incognita chitwood.
Owner:INST OF VEGETABLE & FLOWERS CHINESE ACAD OF AGRI SCI
Multicomponent biological compound agent for livestock
ActiveCN102599345AProtected Live Bacteria ContentImprove disease resistanceAnimal feeding stuffBiotechnologyAntimikrobielle peptide
The invention relates to the technical field of biological agents for livestock, in particular to multicomponent biological compound agent, which comprises, by weight, 94-98% of live bacteria preparation, 0.4-1.0% of fructooligosaccharide, 1.0-4.0% of fly larva antimicrobial peptide protein powder and 0.6-1.0% of herbs. The live bacteria preparation is prepared by graded fermentation. The herbs include 4 parts of radix astragali, 2 parts of root of Chinese pulsatilla, 2 parts of radix sophorae flavescentis, 2 parts of radix codonopsis and 1 part of licorice root, which are subjected to superfine grinding and mixing. The multicomponent biological compound agent is capable of effectively protecting the content of live bacteria in the live bacteria preparation, and also capable of guaranteeing the components to coordinate to function in immunization, so that physical disease resistance of livestock can be improved, and growth and development of livestock can be promoted. The multicomponent biological compound agent can be stored at normal temperature, and animal experiments show that the multicomponent biological compound agent placed at normal temperature for 3 months is still effective.
Owner:山东华牧天元农牧股份有限公司
Pichia pastoris-optimized oncorhynchus mykiss hepcidin, oncorhynchus mykiss hepcidin-containing expression carrier, oncorhynchus mykiss hepcidin-containing strain and applications
The invention provides a pichia pastoris-optimized oncorhynchus mykiss hepcidin gene sequence. Four recombinant plasmids pGAPZAlpha A / pPICZAlphaA-hep and pGAPZAlphaA / pPICZAlphaA-mhep are constructed by utilizing hepcidin genes or segments thereof, and are respectively electrotransformed into pichia pastoris GS115 and KM71H host cells to obtain a recombinant pichia pastoris strain, the recombinant pichia pastoris strain is subjected to culture expression to obtain expression polypeptide with the multi-bacteria resistance activity. The expression polypeptide has stronger bacteriostatic activity on escherichia coli, staphylococcus aureus and a part of fish pathogenic bacteria (vibrio parahaemolyticus 1.2164, aeromonas veronii X-1-06909, aeromonas hydrophila HA-336, and aeromonas veronii CL0901).
Owner:BEIJING FISHERIES RES INST
Fusion polypeptide with antimicrobial and wound healing promoting function
InactiveCN101333258AImprove stabilityBroad-spectrum antibacterialPeptide/protein ingredientsDermatological disorderThrombin activityHuman epidermal growth factor
The invention relates to a fusion polypeptide with anti-bacterial and wound-healing promotion functions. The technical proposal adopted by the invention is that the fusion polypeptide with anti-bacterial and wound-healing promotion functions comprises a human epidermal growth factor of the amino acid sequence described in a sequence form SEQ ID NO.1, a thrombin protein cutting site of the amino acid sequence described in a sequence form SEQ ID NO.2, and a Rana chensinensis antimicrobial peptide of the amino acid sequence described in a sequence form SEQ ID NO.3; the thrombin protein cutting site enables the human epidermal growth factor to be fused with the Rana chensinensis antimicrobial peptide so as to construct a fusion polypeptide which has the amino acid sequence described in a sequence form SEQ ID NO.4. The fusion polypeptide of the invention has good stability and is provided with broad-spectrum antimicrobial and cell division promotional functions after digestion; the fusion polypeptide is infused in forms of gel agents and spraying agents and other agent types and can be applied to the burning, injury and other trauma treatment of human and mammals; the fusion polypeptide has the effects of preventing wound infection and accelerating wound healing.
Owner:LIAONING UNIVERSITY
A kind of yeast engineering bacteria, its preparation method and application
InactiveCN102260632AExpress safetyEfficient expressionFungiPeptide/protein ingredientsAntimikrobielle peptideYeast
The invention is applicable to the technical field of genetic engineering and provides a yeast engineering bacterium, its preparation method and application. The yeast engineering bacterium of the present invention comprises a recombinant plasmid composed of a yeast shuttle plasmid and pokeweed antimicrobial peptide Pa-AMP05 gene. The sequence of the pokeweed antimicrobial peptide Pa-AMP05 gene is shown in SEQ ID NO:1. The yeast engineering bacteria of the embodiment of the present invention uses yeast as the expression system of pokeweed antimicrobial peptide Pa-AMP05 gene, which realizes safe and efficient expression of the gene and is suitable for industrial production.
Owner:SHENZHEN SUNSMILE BIOTECH
Novel antimicrobial peptide derived from myxinidin peptide and uses thereof
ActiveUS20200231628A1Low cytotoxicityHigh activityAntibacterial agentsBiocideAntimikrobielle peptideAntimicrobial peptides
A novel antimicrobial peptide is derived from myxinidin peptide. The novel antimicrobial peptides (i.e., myxinidin 2 and myxinidin 3) have low cytotoxicity for human cells while exhibiting an excellent antimicrobial activity, and exhibit an anti-inflammatory and a wound healing effect. Thus, they can be advantageously used as an effective ingredient of antibiotics, a cosmetic composition, a food additive, an animal feed additive, biopesticides, and a quasi-drug product or the like.
Owner:IND ACADEMIC CORP FOUND YONSEI UNIV
Construction of gene engineering bacteria for expressing recombinant cationic antimicrobial peptides (AMPs) G13 escherichia coli
ActiveCN102212541ALow toxicityIncreased toxicityMicroorganism based processesVector-based foreign material introductionAntimikrobielle peptideEscherichia coli
The invention discloses construction of gene engineering bacteria for expressing recombinant cationic antimicrobial peptides (AMPs) G13 escherichia coli, and belongs to the technical field of gene engineering and biology. A fusion head gene is connected with an AMPs gene to construct recombinant plasmid and convert escherichia coli BL21 competent cells, so that the expression yield is improved, and more effective treatment is obtained. The invention aims to design a shorter fusion head which has higher hydrophobic property, and the C final fragment of the fusion head has more negative charges, so that the fusion head can protect small molecular target AMPs; the toxicity of the AMPs to host cells is neutralized; and the cationic AMPs comprise alpha spiral amphipathic AMPs with net positivecharges and contain nucleotide sequences SEQ ID: NO 1 and SEQ ID: NO 2. According to the construction method, DNA recombination and gene engineering technology such as restriction endonuclease cutting, ligase connection and the like are used.
Owner:广东希普生物科技股份有限公司
Antimicrobial peptide with complex biological activity and preparation method and application thereof
The invention discloses an antimicrobial peptide with complex biological activity and a preparation method and application thereof, and belongs to the technical field of molecular biology. The antimicrobial peptide is derived from scylla paramamosain, the amino acid sequence of the scylla paramamosain is shown in SEQIDNO.1 and the coding sequence of the scylla paramamosain is shown in SEQIDNO.2. The preparation method of the antimicrobial peptide includes the following steps that the total RNA of the scylla paramamosain is extracted to serve as a template, and retranscribing is performed to obtain cDNA; the cDNA is used as the template for PCR amplification to obtain nucleotide fragments containing the coding sequence of antimicrobial peptides, the amplified product and anexpression vectorare subjected to enzyme digestion, connection and transformation, escherichia coli engineering bacteria which can express recombinant antimicrobial peptides are constructed, the escherichia coli engineering bacteria are subjected to induction culture, and recombinant antimicrobial peptides are expressed. The antimicrobial peptides has good antimicrobial and antiviral activities, can be used forpreparing antimicrobial or antiviral agents, and has good application prospects.
Owner:INNER MONGOLIA UNIV OF SCI & TECH
Mesenchymal stem cells with enhanced antimicrobial function as well as application of mesenchymal stem cells in sepsis
InactiveCN107828736AImprove antibacterial propertiesEnhance the ability to neutralize endotoxinAntibacterial agentsPeptide/protein ingredientsRepair tissueAntimicrobial peptides
The invention belongs to the technical field of stem cell treatment, and mainly relates to construction of mesenchymal stem cells modified by antibacterial fusion protein, and application of the mesenchymal stem cells in sepsis. Aiming at the problems that the mesenchymal stem cells are weaker in antimicrobial peptide LL-37 secretion function and cannot easily achieve good antibacterial, anti-endotoxin and anti-inflammatory effects, a recombinant carrier is constructed, a human LL-37 antimicrobial peptide gene and a human bactericidal / permeability enhanced protein active fragment gene rBPI21 are connected in series and are cloned into a virus vector, and the mesenchymal stem cells are infected with a virus and are modified by the virus, so that the mesenchymal stem cells can efficiently secrete and express the broad-spectrum antimicrobial fusion protein and further obtain high efficiency broad-spectrum antibacterial ability while having the ability of regenerating and repairing tissues. The stem cell treatment is effectively combined with gene therapy, so that a new choice is provided for the treatment of the sepsis.
Owner:重庆赛托斯创生物科技发展有限公司
Application of antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome
InactiveCN103623391AGood antiviral effectPowder deliveryPeptide/protein ingredientsEscherichia coliAntimikrobielle peptide
The invention belongs to the technical field of medicines, and in particular discloses application of an antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome. According to the invention, an antimicrobial peptide Protegrin-1 is chemically synthesized according to an amino acid sequence of reported Protegrin-1 firstly; then, antimicrobial activity of the antimicrobial peptide Protegrin-1 is proved through an escherichia coli resistant DH5 alpha experiment, and researches on the antivirus activity of the antimicrobial peptide to HP-PRRSV are made through qRT-PCR, Western-Blot, cell supernatant TCID50 detection, IFA and other methods; and further the antivirus mechanism of the antimicrobial peptide is explained in virus adsorption and entrance into cell processes. The antimicrobial peptide Protegrin-1 is expected to be used as a novel medicine for preventing and controlling porcine reproductive and respiratory syndrome.
Owner:SUN YAT SEN UNIV
Antimicrobial peptides derived from CAP18
The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.
Owner:ACADEMISCH ZIEKENHUIS BIJ DE UNIV VAN AMSTERDAM ACADEMISCH MEDISCH CENT +1
Antimicrobial peptides
ActiveUS20110021415A1Simple structureSimple and efficient to produceAntibacterial agentsBiocideAntimikrobielle peptideMicroorganism
Owner:NOVABIOTICS LTD
Preparation of phage cocktail as therapeutic agent for cow mastitis and use thereof
PendingUS20220347241A1Increase added valueShort course of treatmentAntibacterial agentsViral/bacteriophage medical ingredientsBiotechnologyAntimikrobielle peptide
Disclosed is preparation of a cocktail as a therapeutic agent for cow mastitis and use thereof. A compatibility of phages against the main pathogenic bacteria of cow mastitis is utilized in combination with a specific preparation method to prepare and obtain a therapeutic cocktail preparation. The therapeutic phage cocktail preparation for cow mastitis provided in the disclosure is easy to prepare, short in course of treatment and quick in effect. It has better therapeutic effect on both clinical cow mastitis and recessive mastitis than that of antibiotics and antimicrobial peptide and is expected to solve the problem of bacterial resistance in the treatment of cow mastitis, thereby reducing or getting rid of the troubles of diseases such as mastitis in cows, which is of potential development value in cow farming.
Owner:SHIHEZI UNIVERSITY
Ancient defense polymer
InactiveUS20070104678A1Maintain antimicrobial activitySynthetic polymeric active ingredientsBiological bodyAntimicrobial peptides
The invention relates to an ancient defense polymer having biological activity. The polymer comprises both discrete hydrophilic blocks containing cationic charge(s) and discrete hydrophobic blocks, making it amphipathic and antimicrobial in a manner analogous to natural antimicrobial peptides that form an ancient defense mechanism employed by many organisms. Such a polymer may be formed into devices designed to resist infection or bound to the surface of an apparatus to lend the biological activity to the surface of the apparatus.
Owner:RIMON THERAPEUTICS
Safe and efficient animal semen disinfector and preparation method therefor
ActiveCN104304237AHigh activityExtended storage timeBiocideDead animal preservationClassical swine fever virus CSFVAntimikrobielle peptide
Owner:CHENGDU MEIQIANG VETERINARY TECHNICAL SERVICE CO LTD
Acne-preventing and acne-removing composition containing antimicrobial peptide and application thereof
PendingCN108403582ABalance oil secretionRestore pHAntibacterial agentsCosmetic preparationsAntimikrobielle peptideJuvenile acne
The invention relates to an acne-preventing and acne-removing composition containing antimicrobial peptide and application thereof, which belong to the field of biotechology. The acne-preventing and acne-removing composition containing antimicrobial peptide mainly is prepared from the following components in percentage by weight: 0.01 to 50 percent of antimicrobial peptide, 0.01 to 50 percent of propolis extract, 1 to 99 percent of butanediol and 1 to 99 percent of deionized water. Aimed at the formation mechanism of acne, the acne-preventing and acne-removing composition containing antimicrobial peptide which is disclosed by the invention is scientifically formulated, all the bioactive substances are synergistic, the acne-preventing and acne-removing composition containing antimicrobial peptide has the effects of regulating skin grease secretion, restoring skin pH, resisting oxidation, resisting and killing microbes, diminishing inflammation and relieving itching, enhancing skin immunity, promoting wound healing and the like, and from multiple targets and multiple aspects, the acne-preventing and acne-removing composition containing antimicrobial peptide has a remarkable effect inpreventing and removing acne, and is safe and nonirritating for skin.
Owner:北京皓尔生物科技有限公司
Recombinant human-derived antimicrobial peptide C16LL-37 and application method thereof in streptococcus mutans bioactivity role
InactiveCN106008718AReduce sensitivitySignificant target specificityAntibacterial agentsPeptide/protein ingredientsAntimikrobielle peptideChemical synthesis
The invention relates to the technical field of biological engineering, relates to a recombinant human-derived antimicrobial peptide C16LL-37 and an application method thereof in streptococcus mutans bioactivity role, and analysis application of antimicrobial activity, targeting property, hemolytic property and other bioactivities of the recombinant antimicrobial peptide C16LL-37. A standard solid-phase synthesis technique is adopted for synthesis, an amino acid sequence of a human-derived antimicrobial peptide LL-37 is connected with 16 amino acid sequences CSPC16 of a C end of streptococcus mutans CSP through connecting body-GGG-connection, and the recombinant human-derived antimicrobial peptide C16LL-37 having specific targeting ability is synthesized. In conclusion, with research and development of the human-derived specifically targeted antimicrobial peptide C16LL-37, not only are the problems that natural antimicrobial peptides have broad antimicrobial spectra, easy generation of drug resistance, low biological efficiency, high difficulty of screening and the like solved, but also the shortcomings that chemically synthesized antimicrobial peptides have low chemical combination efficiency and fusion proteins are unstable are overcome. In addition, an AMP region of the C16LL-37 is derived from a human body, so the C16LL-37 has relatively high biological safety and lays a firm foundation for wide application in clinic in future.
Owner:NORTHWEST UNIVERSITY FOR NATIONALITIES
Antimicrobial peptides
InactiveUS7588752B2Reduce solubilityImprove actionAntibacterial agentsCosmetic preparationsCaseinAmino acid
The present invention provides antimicrobial peptides. The peptides are non-glycosylated, less than about 100 amino acids in length, and include an amino acid sequence selected from: AVESTVATLEAΣPEVIESPPE (SEQ ID NO:3), AVESTVATLEDΣPEVIESPPE (SEQ ID NO:4), AVESTVATLEASPEVIESPPE (SEQ ID NO:5), AVESTVATLEDSPEVIESPPE (SEQ ID NO:6), DMPIQAFLLYQQPVLGPVR (SEQ ID NO:7), and conservative substitutions therein. These peptides can be produced synthetically; however, they can most conveniently be derived from casein.
Owner:DAIRY AUSTRALIA
Anti-microbial peptides and coatings
ActiveUS10144767B2Peptide/protein ingredientsRecombinant DNA-technologyAnti microbial peptideAntimicrobial peptides
Owner:BOARD OF RGT UNIV OF NEBRASKA
Rapid specific pathogen free animal
InactiveUS20150173333A1Improve effectivenessAntibody mimetics/scaffoldsEnzymesRibosome-inactivating proteinVirology
A method of producing at least one specific pathogen free (SPF) non-human animal and / or a method of producing at least one specific pathogen resistant (SPR) non-human animal, the method comprising administration of a fusion protein to the surviving animal wherein the fusion protein comprises at least one polypeptide B which is a Type 1 Ribosome Inactivating Protein (RIP) or fragment thereof; and (i) at least one polypeptide A which is an Antimicrobial peptide; and / or (ii) at least one polypeptide C which is a Cationic Antimicrobial Peptide (CAP) or fragment thereof.
Owner:BIOVALENCE
Lantibiotic biosynthetic gene clusters from a. garbadinensis and a. liguriae
This invention relates to characterisation of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterised biosynthetic gene clusters.
Owner:NOVACTA BIOSYSTEMS LTD
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