26 results about "Quaternized chitosan" patented technology

This invention discloses a composite additive for repairing the foaming properties of recycled polystyrene, relating to the field of recycled polystyrene. It comprises: 30-50 parts of a matrix repair component, 20-35 parts of a nucleating-reinforcing composite component, 10-20 parts of an antibacterial and flame-retardant composite component, and 5-10 parts of a dispersant. Modified rosin ester and polybutadiene oligomers are used as the matrix repair component, combined with nano-calcium carbonate and talc as the nucleating-reinforcing composite component, and further combined with phytic acid and quaternized chitosan functional components and zinc stearate dispersant to form a stable composite system. This system imparts antibacterial and flame-retardant properties to the product, solving the problem of single-function traditional additives, significantly improving the quality of recycled material products, realizing high-value utilization of recycled materials, and simultaneously repairing damaged molecular chains in recycled materials, improving processing flowability and cell nucleation effect, thus compensating for the deficiency of reduced foaming performance in recycled polystyrene.

This invention belongs to the field of polymer protective materials technology, and discloses a nitrile glove modified with bio-based itaconic acid ester rubber latex and compounded with an antibacterial agent, as well as its preparation method. The glove uses carboxylated nitrile butadiene latex as the matrix, introduces a bio-based itaconic acid ester rubber latex pretreated with a silane coupling agent as a reactive interfacial compatibility component, and uses nano-silver-zinc composite particles and reactive quaternized chitosan to form an immobilized composite antibacterial phase. The glove is prepared through blending, impregnation molding, surface immobilization treatment, gradient vulcanization, and post-treatment. The resulting glove possesses excellent flexibility, low-temperature embrittlement resistance, oil resistance, and long-lasting antibacterial properties, and the antibacterial components are not easily migrated or detached, making it suitable for food processing, medical auxiliary protection, and low-temperature operations.

The application discloses a mussel-mimic bacterial-responsive injectable hydrogel and a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel is composed of a mussel-mimic viscous hydrogel support and a bacterial response agent; the viscous hydrogel support is QCS-EC, which is formed by non-covalent combination of quaternary ammonium chitosan QCS and epigallocatechin gallate EGCG; and the bacterial response agent is a supramolecular nanometer cross-linking compound TEBox-B 12， which is self-assembled by hydrogen bonds and electrostatic interactions. 12 H 12 2‑ The hydrogel of the application has NIR-II photothermal and photodynamic antibacterial treatment functions, can realize efficient killing of bacteria in deep tissues, has high adhesion, good biocompatibility and injectability, is convenient and applicable, can provide a good healing environment for a wound, promotes fibroblast proliferation and migration, accelerates wound tissue regeneration and healing process, and reduces scar formation.

The application provides a clay stabilizer, a preparation method and a water-based working fluid. The clay stabilizer comprises a quaternary ammonium chitosan zwitterionic polymer, the quaternary ammonium chitosan zwitterionic polymer comprises a chitosan backbone, a carboxyl substituent grafted on the chitosan backbone and a quaternary ammonium salt substituent grafted on the chitosan backbone, the degree of substitution of the carboxyl substituent is 60-80%, the mass percentage of the quaternary ammonium salt substituent in the quaternary ammonium chitosan zwitterionic polymer is 30-60%, and the polydispersity coefficient of the quaternary ammonium chitosan zwitterionic polymer is 2.2-2.5. The clay stabilizer can simultaneously inhibit the hydration and expansion of clay, control the coordinated control of the dispersion, migration and deposition behavior of fine particles under fluid scouring, realize the dynamic migration regulation of clay fine particles, and reduce the entry of clay fine particles into deep narrow pore throats and the induced plugging.

This invention discloses a method for preparing and applying a dual-network sprayable hydrogel for the repair of radiation-induced skin damage. The hydrogel introduces aldehyde groups into Polygonatum odoratum polysaccharide via sodium periodate oxidation, causing it to chemically crosslink with the amino groups of quaternized chitosan to form a first-layer network. Simultaneously, sodium alginate is introduced into the system, and calcium ions are used to crosslink and construct a second-layer physical crosslinking network. This invention achieves instant gelation upon injection under physiological conditions, effectively avoiding the operational complexity caused by pre-mixed crosslinking agents and optimizing gel performance. The resulting hydrogel exhibits significantly improved mechanical and adhesive properties. In vitro cell experiments and in vivo animal experiments show that this sprayable hydrogel can effectively promote cell proliferation and migration, effectively maintain macrophage mitochondrial dysfunction caused by ionizing radiation, and possesses good antioxidant and anti-inflammatory activities, demonstrating broad application prospects in the repair and treatment of radiation dermatitis.

The application belongs to the technical field of medical materials, and specifically discloses a hydrogen production and oxidation resistance hydrogel microneedle patch based on a primary cell effect and a preparation method and application thereof, which comprises the following steps: preparing a polyvinyl alcohol solution, an aldehyde bacterial cellulose solution, a quaternary ammonium chitosan solution and a silver nanowire dispersion; preparing a needle tip solution; preparing a lower substrate solution; preparing an upper substrate solution; preparing a microneedle patch preliminary product; and performing salting-out treatment on the microneedle patch preliminary product with a sulfate solution, so as to obtain the hydrogen production and oxidation resistance hydrogel microneedle patch based on the primary cell effect. The hydrogen production and oxidation resistance hydrogel microneedle patch based on the primary cell effect is prepared by using the above method, the patch can spontaneously generate therapeutic microcurrent and hydrogen in a wound microenvironment, and can realize multi-mechanism synergistic treatment of chronic and difficult-to-heal wounds such as diabetes by synergizing photothermal antibacterial and drug activity.

This invention relates to the field of fluoride-containing wastewater treatment technology, specifically to a method for preparing a high-efficiency composite defluoridating agent and its application. The composite defluoridating agent provided by this invention comprises a composite defluoridating core, a chitosan coating layer, and an F-imprinted outer layer. The composite defluoridating core is formed by in-situ co-precipitation of Mg-Al-La layered double hydroxides by chitosan complexing with Mg, Al, and La metal sources, and the introduction of TiO2 and MnO2 functional oxides. The chitosan coating layer coats the surface of the composite defluoridating core. The F-imprinted outer layer... ‑ The outer layer of the imprint is formed by pre-assembly, cross-linking, and template elution of fluoride ion template, quaternized chitosan, and chitosan. This invention also provides a composite defluorinating agent working solution obtained by mixing a double aluminum salt solution and a composite defluorinating agent dispersion, used for deep defluorination treatment of fluoride-containing wastewater containing competing anions of phosphate, silicate, bicarbonate, and / or carbonate, with advantages such as high defluorination efficiency, good selectivity, and strong anti-interference ability.

This invention provides a membrane material for a bipolar anion exchange layer modified with two-dimensional inorganic materials, specifically quaternized chitosan-based materials. Two-dimensional MgAl-LDH nanosheets are added to a chitosan (QCS) / polyvinyl alcohol (PVA) mixed matrix to construct an inorganic-organic composite material. The ion exchange capacity and mechanical reinforcing ability of the two-dimensional MgAl-LDH give the modified QCS / PVA mixed matrix better ion transport capacity and mechanical strength. This results in a bipolar membrane with this anion exchange layer exhibiting lower transmembrane voltage and membrane surface resistivity, thus improving water dissociation efficiency. The bipolar anion exchange layer of this invention uses low-cost materials, exhibits good ion transport properties, is simple to operate, and has wide applications.

This invention provides a slow-release marine antifouling coating, its preparation method, and its application, belonging to the field of coating technology. The slow-release antifouling coating comprises 50-60 parts epoxy resin, 5-10 parts nano-cuprous oxide hollow spheres, 1-3 parts 7-amino-4-methylcoumarin, 3-5 parts quaternized chitosan, 2-4 parts DCOIT-supported mesoporous SiO2, 3-8 parts fluorosilane-modified SiO2, 0.5-2 parts carbon nanotubes, 5-10 parts polylactic acid microcapsules, and 1-3 parts silane coupling agent. Through the synergistic combination of epoxy resin, nano-cuprous oxide hollow spheres, and 7-amino-4-methylcoumarin, along with other raw materials, this invention prepares a marine antifouling coating with excellent antifouling performance, slow-release performance, adhesion performance, and environmental safety performance. It can effectively cope with the complex marine environment and has good application prospects.

The application discloses a composite functional diaphragm for a zinc-bromine flow battery and a preparation method thereof, and belongs to the technical field of electrochemical energy storage. The diaphragm is based on a microporous membrane or an ion exchange membrane, and a first functional coating facing a positive electrode and a second functional coating facing a negative electrode are constructed on two surfaces of the diaphragm. The first functional coating is composed of a dense nanocomposite network formed by cross-linking quaternary ammonium chitosan and inorganic nanoparticles through a cross-linking agent. The second functional coating is composed of a porous zincophilic composite layer formed by cross-linking quaternary ammonium chitosan and micron-sized zinc powder through a cross-linking agent. By preparing a slurry and coating, a structure-stable asymmetric composite functional diaphragm is formed after solidification. The diaphragm can efficiently anchor polybromide on the positive electrode side to inhibit shuttling, and can induce uniform zinc deposition on the negative electrode side to inhibit dendrites, while ensuring excellent chemical and mechanical stability of the coating in a strong acid and high bromine environment, so that the overall performance of the zinc-bromine flow battery is synergistically and long-acting improved.

The application discloses a kind of red soil microstructure creation agents based on double-network hydrogel and preparation method thereof.The double-network hydrogel is constituted by ionic crosslinking network formed by sodium carboxymethyl cellulose and trivalent iron ions and covalent crosslinking network formed by chitosan crosslinked by epichlorohydrin, and introduces quaternary ammonium chitosan and hydrophilic macromolecule, forms multi-level pore structure.The preparation method includes network construction, compounding, pore forming and post-processing steps.The red soil microstructure creation agent is applied to red soil improvement, can improve soil aggregate stability, reduce soil bulk density by 10%-20%, enhance water-retention capacity to make soil water-holding capacity increase to 800%-1200%, realize fertilizer slow release, nitrogen, phosphorus and potassium release period is extended to 40-60 days, effectively solve the problem of poor structure and weak water and fertilizer retention capacity of red soil, with the advantages of low cost, strong environmental adaptability and the like.

The application discloses an intelligent responsive composite hydrogel dressing and a preparation method and application thereof, and belongs to the field of biomedical materials. The preparation method comprises the following steps: preparing arginine grafted quaternary ammonium chitosan LQ; preparing phenylboronic acid functionalized oxidized sodium alginate P-OSA; preparing a multifunctional nanoenzyme complex PMZG; mixing polyvinyl alcohol, LQ, honeysuckle extract and / or PMZG, and then cross-linking with a P-OSA solution to obtain a hydrogel. Through progressive modular design, the hydrogel is endowed with injectability, self-healing, multiple microenvironment responsiveness and cascade catalytic antibacterial, photothermal therapy and pro-angiogenesis capabilities, and can be used for synergistically treating chronic infected wounds, diabetic foot ulcers and drug-resistant bacterial infection wounds, and has a wide clinical application prospect.

The present application belongs to the technical field of plastic flooring, and specifically relates to an environmentally friendly non-PVC flooring and a preparation method therefor. The flooring is sequentially provided with a transparent sheet layer, a colored film layer, a base material layer, and a cushioning layer from top to bottom, wherein the base material layer comprises PET, PETG, calcium carbonate powder, a plasticizer, a toughening agent, an outer lubricant, an inner lubricant, and an oxidized wax. For the transparent sheet layer and the cushioning layer, quaternized chitosan-coated nano-zinc oxide loaded with trivalent titanium is used as an antibacterial material, thereby having good dispersibility and antibacterial properties. By using fibrilia modified by cork particles and nano fumed silica as a substrate, a cushioning layer bonded by means of the hot pressing of PP and PE has an enhanced sound insulation effect and mechanical properties.

This invention belongs to the field of bioassay technology, and specifically relates to a method and kit for detecting oxidized low-density lipoprotein (ODL). This invention provides a novel application of quaternized chitosan in the kit, specifically using quaternized chitosan of different molecular weights in the immunoturbidimetric detection of ODL. Results show that when high molecular weight quaternized chitosan (100-200 kDa) and low molecular weight quaternized chitosan (30-50 kDa) are used as components of the ODL detection kit, the different molecular weights of quaternized chitosan react with citrate to form gel particles of varying mechanical strengths. This allows for the detection of ODL content via immunoturbidimetry. Furthermore, the use of quaternized chitosan of different molecular weights significantly improves the sensitivity and linear range of the ODL detection kit.

This invention belongs to the field of environmental functional materials and water treatment technology, specifically relating to a multifunctional aerogel membrane based on charge-induced demulsification, its preparation method, and its applications. The oil-water separation aerogel membrane prepared by this invention uses quaternized chitosan as the backbone and agricultural waste corn cobs as the filler material, prepared through a directional freeze-drying composite process. This aerogel membrane combines multiple functions including oil-water separation, emulsion demulsification, and dye adsorption. For oil-water mixtures, after 10 cycles of recycling, the separation flux can maintain more than 85% of the initial flux, with a separation efficiency of up to 99%. The separation efficiency for different types of oil-in-water emulsions can reach over 97%. Furthermore, the raw materials are renewable, and the preparation process is green and environmentally friendly, solving the problems of weak demulsification ability, single function, and poor environmental friendliness of traditional oil-water separation materials. It can be widely used in oily wastewater treatment, industrial wastewater treatment, and other fields.

This invention discloses an amino acid-modified quaternized chitosan, its preparation method, and its application in the preparation of antibacterial products, relating to the field of antibacterial materials technology. The amino acid-modified quaternized chitosan comprises a quaternized chitosan backbone and amino acids covalently grafted onto the quaternized chitosan backbone. The degree of quaternization of the amino acid-modified quaternized chitosan is 0.2–1.6, the degree of amino acid grafting is 0.1–0.8, and the weight-average molecular weight is 5 × 10⁻⁶. 3 ~8×10 5 g / mol. The degree of quaternization substitution, degree of amino acid grafting, and weight-average molecular weight of the amino acid-modified quaternized chitosan provided by this invention are all controlled within the above range, which ensures that the material has good antibacterial and bactericidal effects, and also has good biocompatibility and low cytotoxicity.

The application discloses a kind of based on space-time sequential nature magnetic control membrane rupture and release sterilization mechanism multiple antibacterial composite coating material and its preparation method and application, preparation method is as follows: 1) using micro-arc oxygen technology is constructed microporous structure on the surface of titanium-based instrument after pretreatment;2) using emulsion self-assembly method constructs quaternary ammonium chitosan and negative charged antibacterial agent nanoparticle, using one pulse electrophoresis process is loaded in micropore nanoparticle;3) Fe3O4 NPs are prepared by hydrothermal method, and Fe3O4 NPs are controlled in micropore by secondary pulse electrophoresis process, after washing, drying and irradiation sterilization, antibacterial composite coating is obtained;The material can be driven Fe3O4 NPs on titanium-based instrument to generate torque to destroy bacterial biofilm by applying reverse circular polarized magnetic field, and promote the inner layer to release antibacterial agent, realize space-time sequential nature magnetic control membrane rupture and release sterilization, realize efficient treatment for bone infection.

This invention discloses a self-gelling porous hemostatic microsheet, its preparation method, and its application; belonging to the field of hydrogel technology. The method first prepares two raw materials in a sponge-like state: quaternized chitosan grafted with gallic acid and oxidized hyaluronic acid. Then, the two raw materials are separately pulverized into microsheets using a pulverizer. After controlling the size of the microsheets through a sieve, the two types of microsheets are mixed to prepare a porous hemostatic microsheet. This hemostatic microsheet combines the advantages of sponge, hydrogel, and powder, achieving rapid hemostasis and efficient wound healing. The hemostatic microsheet has a large specific surface area and excellent hydrophilicity, enabling rapid blood absorption. It achieves self-gelling through electrostatic interaction and Schiff base crosslinking, forming a dense, porous hydrogel adhesive. The porous hemostatic microsheet possesses excellent mechanical properties, adhesive strength, and ultra-high burst pressure, while also exhibiting biocompatibility, biodegradability, and procoagulant and antibacterial properties.

The application belongs to the technical field of vaccines, and particularly relates to a subunit vaccine for preventing and controlling porcine epidemic diarrhea of piglets. The subunit vaccine comprises an antigen and an adjuvant, the antigen is PEDV S protein, the adjuvant is O / W type nanoemulsion adjuvant TMC-NE based on quaternary ammonium chitosan, the TMC-NE is prepared from an oil phase, mixed surfactant and an aqueous phase as raw materials, and the mass ratio of the oil phase, the mixed surfactant and the aqueous phase is 15:35:50. The subunit vaccine for preventing and controlling porcine epidemic diarrhea of piglets effectively improves the immunogenicity of the antigen, induces the body to produce a more balanced Th1 / Th2 response, stimulates the body to produce effective cellular immunity and humoral immunity, and adjusts adaptive immune response by loading PEDV S protein on quaternary ammonium chitosan nanoemulsion to immunize piglets. It is also indicated that the quaternary ammonium chitosan nanoemulsion has application potential as an immune adjuvant, and the prepared PEDV S subunit vaccine is expected to become a new vaccine for effectively preventing and controlling porcine epidemic diarrhea.

This invention discloses a low-temperature, high-efficiency phosphorus removal composite agent for frigid regions and its preparation method, belonging to the technical field of water treatment and environmental functional materials. The composite agent is composed of 50-60 parts of iron-aluminum-magnesium modified magnetic mesoporous silica@zirconium-quaternized chitosan, 15-20 parts of a low-temperature activating component, 10-15 parts of a crystallization inducer, and 10-15 parts of an adsorption-enhancing carrier. The components of this invention synergistically form a cascade synergistic chain of "rapid adsorption-micro-area precipitation-induced crystallization-carrier dispersion," achieving highly efficient phosphorus removal in near-freezing-point water bodies. It also allows for magnetic separation and recovery, reducing phosphorus removal costs and making it suitable for wastewater treatment in frigid regions.

The application discloses a glucose-ultrasound double-response intelligent multi-effect hydrogel dressing and a preparation method and application thereof. The gel system takes quaternary ammonium chitosan and a double bond modified product thereof as a macromolecular framework, glucose in a microenvironment of a wound surface as a substrate, generates carbon radicals through a glucose oxidase / glycine ferrous ion cascade catalytic reaction, combines dimethyl acrylamide as a small molecular monomer, and realizes second-level gelation. The hydrogel is coated with a conjugated polymer PFODBT and a raphanusan stabilized by F127. The PFODBT can continuously generate reactive oxygen under the action of ultrasound, and cooperates with the cation of quaternary ammonium chitosan to play an antibacterial role. The SFN has persistent anti-inflammatory and antioxidant effects and promotes angiogenesis. The application constructs an intelligent response hydrogel dressing integrated with'sugar control-antibacterial-promoting repair' through a simple and mild enzymatic gelation method, provides a new treatment strategy for chronic wound repair of diabetes, and has a wide application prospect.

This invention discloses a method for preparing and applying a quaternized chitosan-stabilized selenium nanoparticle composite hydrogel, comprising the following components: quaternized chitosan selenium nanoparticles, chitosan, collagen, and oxidized konjac glucomannan. The collagen solution has a concentration of 1% w / v, the chitosan solution has a concentration of 2% w / v, the oxidized konjac glucomannan solution has a concentration of 2.4% w / v, and the concentrations of quaternized chitosan selenium nanoparticles are 10, 20, and 50 μg / mL. The volume ratio of collagen, chitosan, and oxidized konjac glucomannan is 1:1:1. This antibacterial hydrogel combines chitosan, collagen, oxidized konjac glucomannan, and quaternized chitosan selenium nanoparticles, exhibiting excellent antibacterial properties. The hydrogel enables the slow and continuous release of selenium nanoparticles, prolonging the antibacterial action time and improving the antibacterial efficacy and duration. It also demonstrates excellent wound-healing capabilities and shows promising application prospects in the healing of open wounds.

The application discloses a bacteriostatic and moisturizing soap extract hand sanitizer and a preparation method thereof. The hand sanitizer takes a soap extract as a basic raw material, cooperatively modifies the soap extract through citric acid and quaternary ammonium chitosan, obtains modified soap extract with significantly improved stability and mildness, and introduces an organic small molecule myopeptide which is not applied in the field of hand sanitizer into the modified soap extract on the basis, and is prepared in combination with an amino acid type surfactant, a non-ionic surfactant, a moisturizing agent, a thickening agent and a bacteriostatic auxiliary agent and the like. The hand sanitizer has good bacteriostatic effect in the cleaning process, can form a stable moisturizing environment on the skin surface after washing, has the synergistic enhancement effect of bacteriostatic performance and moisturizing performance, and reduces the irritation to the skin. The preparation method is simple in process and mild in condition, the obtained hand sanitizer is suitable for high-frequency hand washing scenes, and has a good application prospect.

This invention belongs to the field of environmental functional materials and water treatment technology, specifically relating to a multifunctional aerogel membrane based on charge-induced demulsification, its preparation method, and its applications. The oil-water separation aerogel membrane prepared by this invention uses quaternized chitosan as the backbone and agricultural waste corn cobs as the filler material, prepared through a directional freeze-drying composite process. This aerogel membrane combines multiple functions including oil-water separation, emulsion demulsification, and dye adsorption. For oil-water mixtures, after 10 cycles of recycling, the separation flux can maintain more than 85% of the initial flux, with a separation efficiency of up to 99%. The separation efficiency for different types of oil-in-water emulsions can reach over 97%. Furthermore, the raw materials are renewable, and the preparation process is green and environmentally friendly, solving the problems of weak demulsification ability, single function, and poor environmental friendliness of traditional oil-water separation materials. It can be widely used in oily wastewater treatment, industrial wastewater treatment, and other fields.

This invention relates to the field of shampoo technology, and discloses an antibacterial shampoo and its preparation method. The antibacterial shampoo is prepared from deionized water, disodium ethylenediaminetetraacetate, polyquaternium-10, sodium lauryl ether sulfate aqueous solution, cocamidopropyl betaine aqueous solution, an antibacterial agent, dimethyl silicone oil, phenoxyethanol, sodium chloride, fragrance, and citric acid aqueous solution. The antibacterial agent is obtained by spray drying a mixture of aminated graphene quantum dots, quaternized chitosan powder, modified lithium saponite powder, and deionized water. The modified lithium saponite powder is prepared from lithium saponite powder, deionized water, and a hexadecyltrimethylammonium bromide ethanol solution. The quaternized chitosan powder is prepared from chitosan powder, acetic acid aqueous solution, 2,3-epoxypropyltrimethylammonium chloride aqueous solution, and sodium hydroxide aqueous solution. The aminated graphene quantum dots are prepared from L-histidine, citric acid monohydrate, and deionized water. This invention exhibits excellent antibacterial properties.