106 results about "Quaternized chitosan" patented technology

The invention discloses a special ergothioneine-containing skin repair hydrogel for pets and a preparation method of the special ergothioneine-containing skin repair hydrogel, and belongs to the technical field of pet skin care hydrogels. The invention relates to a skin care product which comprises the following components in parts by weight: 1.6-3.8 parts of a functional active component consisting of ergothioneine, quaternized chitosan and oat beta-glucan, 0.15-0.35 part of a cross-linking agent, 5-10 parts of 1, 3-propylene glycol, 5-10 parts of glycerol, 0.2-0.5 part of a preservative and the balance of water, totaling 100 parts. Through precise compatibility of functional active components and synergistic construction of the ionic cross-linked gel matrix, systematic integration of three effects of oxidation resistance, bacteria resistance and healing promotion is achieved, and the technical problems that an existing pet skin care product is single in function, insufficient in synergy and limited in repairing effect are solved.

The invention provides a nylon fabric color fixing agent and a preparation method thereof, the color fixing agent comprises a bio-based compound and a nano barrier component, the bio-based color fixing component is a compound formed by quaternized chitosan, tannic acid and zirconium ions, and the nano barrier component is cellulose nanocrystalline-ZIF-8-coated SiO2 core-shell particles. The color fixing agent disclosed by the invention avoids the use of bisphenol compounds in the traditional color fixing process, and has the characteristic of environmental protection.

The invention belongs to the technical field of lithium ion battery materials, and particularly relates to a carbon-coated aluminum foil coating and a preparation method thereof. The invention aims to solve the problem of contradiction between high conductivity and strong adhesive force of the current carbon-coated aluminum foil coating. According to the invention, a multi-stage dimensional composite conductive network is taken as a design core, and the conductive performance of the coating is improved through a ternary composite system formed by conductive carbon black, one-dimensional carboxylated multi-walled carbon nanotubes and two-dimensional sulfonated graphene oxide; the binder adopts a bio-based water-based system and is formed by compounding carboxylated cellulose nanocrystals and quaternized chitosan, and a compact and tough bonding network layer is formed through electrostatic interaction and hydrogen bond combination; the conductive adhesive is excellent in conductivity and strong in adhesive force, the preparation process is environment-friendly and efficient, and the contradictory problem that the conductivity and the adhesive force are difficult to consider at the same time in the prior art is solved.

This invention discloses a composite additive for repairing the foaming properties of recycled polystyrene, relating to the field of recycled polystyrene. It comprises: 30-50 parts of a matrix repair component, 20-35 parts of a nucleating-reinforcing composite component, 10-20 parts of an antibacterial and flame-retardant composite component, and 5-10 parts of a dispersant. Modified rosin ester and polybutadiene oligomers are used as the matrix repair component, combined with nano-calcium carbonate and talc as the nucleating-reinforcing composite component, and further combined with phytic acid and quaternized chitosan functional components and zinc stearate dispersant to form a stable composite system. This system imparts antibacterial and flame-retardant properties to the product, solving the problem of single-function traditional additives, significantly improving the quality of recycled material products, realizing high-value utilization of recycled materials, and simultaneously repairing damaged molecular chains in recycled materials, improving processing flowability and cell nucleation effect, thus compensating for the deficiency of reduced foaming performance in recycled polystyrene.

The invention discloses a modified chitosan-based antibacterial material as well as a preparation method and application thereof, and belongs to the technical field of antibacterial materials. The ciprofloxacin grafted quaternized chitosan is successfully synthesized by taking the chitosan as a raw material, and the water solubility and the antibacterial ability of the chitosan are effectively improved. The antibacterial diameters of the ciprofloxacin grafted quaternized chitosan prepared by the preparation method disclosed by the invention on escherichia coli and staphylococcus aureus are respectively 35.34 to 39.06 mm and 40.45 to 44.51 mm, and the minimum MIC (Minimum Inhibitory Concentration) and MBC (Minimum Mass Chitosan) can reach 0.0005 mg / mL. In addition, the antibacterial material has an obvious inhibition effect on colletotrichum gloeosporioides and aspergillus niger, and the highest antifungal rates respectively reach 53.81 + / -2.17% and 54.88 + / -1.3%. Compared with the raw materials, the antibacterial ability is greatly improved, and the grafted and modified composite material is environment-friendly and can be used for antibacterial food packaging materials.

This invention discloses a formaldehyde-free modified guar gum wood adhesive, its preparation method, and its application, belonging to the field of wood adhesive technology. It aims to solve the problems of environmental pollution caused by traditional formaldehyde-containing adhesives and the poor water resistance and insufficient bonding strength of guar gum itself. The method includes: dissolving guar gum and then oxidizing and degrading it with hydrogen peroxide, followed by activation with a silane coupling agent, reinforcement with polyvinyl alcohol, and modification by butyl acrylate graft copolymerization. Finally, a cross-linking reaction is carried out simultaneously with the addition of a wood interface modifier composed of sodium lignosulfonate, quaternized chitosan, nano-cellulose whiskers, and nano-zirconia supported zirconium phosphate. The reaction environment is optimized by adjusting the pH of the system to 6.0-6.5. The adhesive obtained by this invention is environmentally friendly and formaldehyde-free, suitable for high-strength bonding of eucalyptus plywood.

The invention belongs to the field of functional textile materials and filtering materials, and provides a multi-effect functional non-woven fabric. According to the invention, a collaborative design of a composite non-woven structure and an immobilized functional layer is adopted, and the composite non-woven structure is composed of a spun-bonded layer containing polyamide 6 and a melt-blown layer containing maleic anhydride grafted polyamide 6; the immobilized functional layer comprises quaternized chitosan-sodium tripolyphosphate ionic cross-linked nanoparticles and forms amido bonds through ring-opening reaction of anhydride groups and amino groups, and the amido bonds are firmly fixed on the surface of the composite non-woven structure; multiple properties such as low-pressure-drop high-flux filtration, efficient particulate matter trapping, high-positive-charge antibacterial and hydrophilic multi-effect synergy, long-acting stable fixation of a functional layer in a humid and hot environment and the like are realized, and the technical problem that performance synergy, interface stability and process compatibility of an existing filtration protection material are difficult to consider is solved; wide application values are realized in the fields of air filtration, personal protection, medical treatment and public health and the like.

The invention discloses a PVC fireproof plate prepared from oyster shells and a preparation method of the PVC fireproof plate, and relates to the technical field of PVC fireproof materials. The preparation method comprises the following steps: step 1, pretreating the oyster shell powder, and reacting quaternized chitosan with epoxidized soybean oil to obtain enhanced oyster shell powder; 2, the oyster shell powder is pretreated, benzophenone chitosan and epoxidized soybean oil are subjected to a reaction, and anti-ultraviolet oyster shell powder is obtained; and step 3, uniformly mixing the raw material components of the PVC fireproof plate according to the formula proportion, adding the mixture into a conical twin-screw extruder, and carrying out mixing extrusion, mold shaping, traction and cutting to obtain the PVC fireproof plate. The prepared PVC fireproof plate has excellent heat resistance, mechanical properties and ultraviolet resistance.

The invention discloses a production process of a cellulose acetate fiber fabric containing natural fragrance, a solvent formed by mixing a modified polymer, 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide, a modified microcapsule and dimethylformamide is subjected to dry spinning to prepare the cellulose acetate fiber fabric, and the weight part ratio of the modified polymer to the modified microcapsule is (70-80): (6-8). The preparation method comprises the following steps: by taking an isocyanate group on excessive hexamethylene diisocyanate as a reaction site, firstly reacting with an intermediate containing dihydroxyl, and then reacting with cellulose acetate containing free hydroxyl, so as to prepare the modified polymer. The halamine structure on the molecular chain can destroy cell membranes, enzyme systems or genetic materials through oxidation. The modified capsule has a lavender essential oil and cinnamon essential oil double-component double-capsule-wall structure, the fragrance durability can be improved, the copper sulfide nanoparticles and quaternized chitosan structures can destroy the bacterial cell structure, and the antibacterial performance of the material is improved.

The invention belongs to the technical field of adhesive materials, and particularly relates to a modified starch-based water-based adhesive as well as a preparation method and application thereof. According to the adhesive, oxidized corn starch is taken as a base material, hydrophobic and weather-resistant modification is realized by introducing a fluorine-silicon-containing functional monomer, and hydroxypropyl quaternized chitosan is compounded to endow antibacterial property and a film-forming enhancement effect; a borax cross-linked polyol system is supplemented to improve the cohesive strength, and a plasticizer, a thickening agent and an emulsifier are matched to optimize the rheological property and wettability. The preparation process comprises the steps of starch gelatinization, fluorosilicone urea grafting, chitosan derivative compounding, auxiliary agent blending and the like, and the process is mild, environment-friendly and non-toxic. The obtained water-based adhesive has the characteristics of strong initial adhesion, good water resistance, moderate flexibility, excellent biocompatibility and the like, and is especially suitable for adhesion and manufacturing of ball products such as basketballs, footballs and the like.

This invention belongs to the field of polymer protective materials technology, and discloses a nitrile glove modified with bio-based itaconic acid ester rubber latex and compounded with an antibacterial agent, as well as its preparation method. The glove uses carboxylated nitrile butadiene latex as the matrix, introduces a bio-based itaconic acid ester rubber latex pretreated with a silane coupling agent as a reactive interfacial compatibility component, and uses nano-silver-zinc composite particles and reactive quaternized chitosan to form an immobilized composite antibacterial phase. The glove is prepared through blending, impregnation molding, surface immobilization treatment, gradient vulcanization, and post-treatment. The resulting glove possesses excellent flexibility, low-temperature embrittlement resistance, oil resistance, and long-lasting antibacterial properties, and the antibacterial components are not easily migrated or detached, making it suitable for food processing, medical auxiliary protection, and low-temperature operations.

The invention belongs to the technical field of biological detection, and particularly relates to a detection method and a detection kit for oxidized low-density lipoprotein. The invention provides a novel application of quaternary ammonium salt chitosan in a kit, and particularly relates to application of quaternary ammonium salt chitosan with different molecular weights in an immunoturbidimetry detection process of oxidized low-density lipoprotein. When high-molecular-weight quaternized chitosan with the molecular weight of 100-200 kDa and low-molecular-weight quaternized chitosan with the molecular weight of 30-50 kDa are used as components of the oxidized low-density lipoprotein detection kit, the quaternized chitosan with different molecular weights can react with citrate radicals to form gel particles with different mechanical strengths; the content of the oxidized low-density lipoprotein can be detected through immunoturbidimetry, and the sensitivity and the linear range of the oxidized low-density lipoprotein detection kit are greatly improved and widened by using the quaternized chitosan with different molecular weights.

The invention relates to the technical field of adsorbents, and discloses a preparation method and application of a sunflower stem pith foam adsorption material.The preparation method comprises the steps that microfibrillated cellulose, quaternized chitosan and sunflower stem pith powder are put into a beaker to be mixed, a cross-linking agent is added, and stirring cross-linking is conducted; and then cryopreserving and thawing to prepare the composite sunflower stem pith foam adsorption material with the dispersed sunflower stem pith powder wrapped by the chitosan. Chitosan is used as a support to support and disperse sunflower stem pith powder, so that sunflower stem pith agglomeration is avoided, and active adsorption sites are increased. The adsorption capacity of the sunflower stem pith foam adsorption material prepared by the method is greatly increased, the adsorption capacity of Congo red is 9 times that of uncompounded sunflower stem pith, the performance is greatly improved, and the sunflower stem pith foam adsorption material can be applied to adsorption of hydrophobic and anionic azo dyes and has a good application prospect. The adsorbent has the advantages of low cost, simplicity in preparation, no chemical pollution, reproducibility, excellent adsorption performance and the like.

The invention belongs to the technical field of medical materials, and particularly discloses a primary battery effect hydrogen production anti-oxidation hydrogel microneedle patch and preparation and application thereof.The method comprises the following steps that a polyvinyl alcohol solution, a hydroformylated bacterial cellulose solution, a quaternized chitosan solution and a silver nanowire dispersion liquid are prepared; preparing a needle tip solution; preparing a lower substrate solution; preparing an upper-layer substrate solution; preparing a microneedle patch primary product; and carrying out salting-out treatment on the primary product of the microneedle patch by using a sulfate solution to obtain the hydrogen-producing antioxidant hydrogel microneedle patch based on the primary battery effect. According to the primary battery effect hydrogen production anti-oxidation hydrogel microneedle patch and preparation and application, the patch can spontaneously generate therapeutic micro-current and hydrogen in a wound microenvironment, photo-thermal antibiosis and drug activity are cooperated, and then multi-mechanism synergistic treatment of chronic refractory wounds such as diabetes and the like is achieved.

The invention provides antibacterial hydrogel artificial skin and a preparation method thereof, and belongs to the technical field of 3D printing biomaterials, the antibacterial hydrogel artificial skin is prepared from the following raw materials by weight: 1-3 parts of aluminum chloride hexahydrate, 30-45 parts of water, 15-22 parts of graft modified chitosan, 8-15 parts of acrylamide, and 1-3 parts of N, N-dimethylformamide. The coating comprises the following components in parts by weight: 0.2-0.8 part of N, N '-methylene bisacrylamide, 0.5-1.5 parts of a photoinitiator, 6-12 parts of quaternized chitosan and 4-8 parts of nano-hydroxyapatite. Wherein the graft modified chitosan is prepared from the following raw materials: 5 to 10 parts of chitosan, 80 to 120 parts of acetic acid solution with the concentration of 2 percent, 0.8 to 2.5 parts of glycidyl methacrylate and 0.05 to 0.2 part of azodiisobutyronitrile. According to the application, by adopting a formula taking the grafted modified chitosan as a core, a collaborative design of multi-scale crosslinking and personalized 3D printing is formed, high mechanical strength, broad-spectrum long-acting bacteriostasis, precise form adaptation and excellent biocompatibility of the hydrogel are realized, and the clinical complex wound repair requirements are met.

The invention discloses antibiotic-loaded in-situ modified platelet-rich fibrin gel as well as a preparation method and application thereof. The antibiotic-loaded in-situ modified platelet-rich fibrin gel is prepared from the following components in percentage by mass: 88 to 92 percent of PRF (platelet-rich fibrin) matrix, 5 to 8 percent of antibiotic and 3 to 4 percent of modifier, the PRF matrix comprises platelets, leukocytes and fibrin, the antibiotic is vancomycin or gentamicin, and the modifier is a zinc ion-containing compound or quaternized chitosan. The gel can be applied to preparation of chronic infection wound dressing, the antibiotic loading rate of the gel is increased, the gel has the slow release characteristic, the accumulative release within 7 days is 82.3 + / -5.6%, the burst release within 24 hours is less than 15%, the wound healing speed is increased by 40%, and the biological membrane clearance rate is 100%.

The invention relates to the technical field of biomass materials and electrochemistry, in particular to a composite anion exchange membrane based on hermetia illucens chitosan and a preparation method and application of the composite anion exchange membrane. Quaternized hermetia illucens chitosan is used as a conductive matrix and is compounded with TEMPO oxidized nanocellulose with the surface rich in carboxyl and an epoxy silane coupling agent, a cross-linking reaction is initiated through heat treatment, and a three-dimensional network structure synergistically enhanced by physical entanglement and chemical cross-linking is constructed. Wherein the epoxy silane coupling agent is covalently cross-linked with active groups of the quaternized chitosan and carboxyl groups on the surface of the nanocellulose at the same time, so that a stable organic / inorganic hybrid network is formed. The structure effectively inhibits the key problems that a polymer chain is easy to swell and poor in mechanical strength in a strong alkali environment, and endows the membrane with excellent comprehensive performance: the tensile strength of the membrane reaches 22-38 MPa, the area swelling rate in 1M KOH is less than 20%, the conductivity at 80 DEG C is 102-125 mS / cm, and the performance retention rate is still greater than 82% after accelerated aging at 1M KOH and 80 DEG C for 720 h.

This invention discloses a composite hemostatic sponge for deep and narrow wounds with massive bleeding and its preparation method. The composite hemostatic sponge is prepared by low-temperature polymerization and cross-linking of gelatin, dopamine, quaternized chitosan, and oxidized dextran, followed by freeze-drying. The composite hemostatic sponge possesses advantages such as high hemostatic efficiency, water-triggered shape recovery behavior, high compressive strength, strong antibacterial activity, safety and non-toxicity, and good blood / biocompatibility. It can effectively prevent fatal bleeding from deep and narrow wounds by combining physical and chemical hemostasis. The composite hemostatic sponge prepared by this invention has widely available raw materials, a simple preparation method, and can be mass-produced, showing potential clinical application value in bleeding scenarios such as deep and narrow wounds and ballistic injuries.

The invention provides a preparation method of an environment-friendly antibacterial uranium extraction polyacrylonitrile fiber, and belongs to the technical field of uranium extraction. The preparation method comprises the following steps: preparing quaternized chitosan with the substitution degree of 50-90% from a quaternary ammonium salt cationic etherifying agent and chitosan; enabling the quaternized chitosan to react with the polyacrylonitrile fiber to obtain the quaternized chitosan modified polyacrylonitrile fiber with the grafting rate of 1 to 40 percent; and reacting the quaternized chitosan modified polyacrylonitrile fiber with a hydroxylamine compound to prepare the environment-friendly antibacterial uranium extraction polyacrylonitrile fiber with an amidoximation grafting rate of 10-45%. According to the method, quaternized chitosan is used as an antibacterial agent and amidoxime is used as an adsorbent to be introduced into polyacrylonitrile fibers by adopting a simple, convenient, efficient and low-cost normal-pressure modification method, so that the method has a good antibacterial effect and high uranium adsorption efficiency in a full pH value range, and is environment-friendly.

The application discloses a mussel-mimic bacterial-responsive injectable hydrogel and a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel is composed of a mussel-mimic viscous hydrogel support and a bacterial response agent; the viscous hydrogel support is QCS-EC, which is formed by non-covalent combination of quaternary ammonium chitosan QCS and epigallocatechin gallate EGCG; and the bacterial response agent is a supramolecular nanometer cross-linking compound TEBox-B 12， which is self-assembled by hydrogen bonds and electrostatic interactions. 12 H 12 2‑ The hydrogel of the application has NIR-II photothermal and photodynamic antibacterial treatment functions, can realize efficient killing of bacteria in deep tissues, has high adhesion, good biocompatibility and injectability, is convenient and applicable, can provide a good healing environment for a wound, promotes fibroblast proliferation and migration, accelerates wound tissue regeneration and healing process, and reduces scar formation.

The invention relates to injectable hydrogel as well as a preparation method and application thereof, and solves the technical problems that an existing suture hiding needle is longer in degradation time and easy to cause inflammatory response, and the injectable hydrogel is prepared from the following components in percentage by mass: 3-10% of oxidized dextran, 2-10% of carboxymethyl chitosan, 0.5-1% of quaternized chitosan, 0.5-1% of chitosan oligosaccharide and the balance of water. The material can be used as an acupoint catgut embedding material.

The invention relates to the technical field of medical application, in particular to medical sodium hyaluronate application as well as a preparation method and application thereof. The plaster is prepared from the following raw materials: modified sodium hyaluronate, quaternized chitosan, asiaticoside, vitamin B5, glycerol and deionized water. Wherein the modified sodium hyaluronate is prepared by acylating and modifying sodium hyaluronate through acetic anhydride. The preparation method comprises the following steps: mixing the raw materials to prepare a mixed solution, adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to carry out a cross-linking reaction, coating the medical non-woven fabric with the obtained cross-linking solution, carrying out vacuum drying, and carrying out sterile cutting and packaging to obtain a finished product. According to the application, the enzymolysis resistance of sodium hyaluronate can be improved, the stability is enhanced through a cross-linked structure, the raw materials synergistically achieve the antibacterial and repairing effects, the biocompatibility is excellent, slight scalds and skin barrier damaged wounds after laser treatment can be assisted to be repaired, and the clinical application value is high.

The invention belongs to the technical field of essential oil, and relates to two-component pawpaw extract essential oil and a preparation method thereof. The essential oil is two-component essential oil, modified quaternized chitosan is added to serve as an auxiliary emulsification auxiliary agent, the auxiliary agent achieves reversible regulation and control of system emulsification-demulsification based on cooperation of the thermo-sensitive phase change characteristic of N-isopropylacrylamide and the interfacial activity of the quaternized chitosan, the inactivation and sensitization risks of active ingredients are reduced, and the essential oil conforms to the natural skin care trend; the chaenomeles speciosa extract is added into the essential oil, so that the essential oil has the effects of replenishing and locking water, resisting oxidation and the like.

The invention belongs to the technical field of cobalt ginseng extraction processes, and particularly relates to a ginseng extract, a preparation method thereof and application of the ginseng extract in feed. The preparation method of the ginseng extract comprises the following steps: carrying out flocculation and impurity removal treatment on a ginseng enzymolysis extracting solution by adopting a graft copolymerization quaternized chitosan flocculant suspension, and purifying a flocculated supernatant, so as to obtain the ginseng extract, the dosage of the graft copolymerization quaternized chitosan flocculant suspension is 0.5%-1.5% of the volume of the ginseng enzymolysis extracting solution. According to the preparation method of the ginseng extract provided by the invention, the compound enzymolysis method, the selective flocculant impurity removal and the macroporous resin adsorption are cooperated, so that the prepared ginseng extract is high in purity, and various effective components such as ginsenoside Rg1, Rb1 and Re are reserved.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention discloses a medical hemostatic sponge material and a preparation method thereof, and relates to the field of hemostatic materials. According to the medical hemostatic sponge material, silk fibroin and sodium carboxymethyl starch are adopted as main matrixes, a small amount of quaternized chitosan is compounded, the problem of acidic degradation of a traditional chitosan system is solved, and meanwhile the hemostatic activity of polysaccharide is reserved; the mussel mucin provides super-strong biological adhesion, so that the problem that the material falls off at a dynamic bleeding part is solved; the RADA16 polypeptide is self-assembled to form a nanofiber network, an extracellular matrix structure is simulated, platelet anchoring and tissue repair are promoted, and meanwhile, foreign matter reaction is reduced; diatom biomineralized silicon DBS activates an endogenous blood coagulation pathway through a surface silanol group, DMSN-loaded thrombin accurately activates exogenous blood coagulation, calcium glycerophosphate provides calcium ions to strengthen a blood coagulation cascade reaction, and the three parts cooperate to realize blood coagulation activation.

This invention discloses a method for preparing and applying a dual-network sprayable hydrogel for the repair of radiation-induced skin damage. The hydrogel introduces aldehyde groups into Polygonatum odoratum polysaccharide via sodium periodate oxidation, causing it to chemically crosslink with the amino groups of quaternized chitosan to form a first-layer network. Simultaneously, sodium alginate is introduced into the system, and calcium ions are used to crosslink and construct a second-layer physical crosslinking network. This invention achieves instant gelation upon injection under physiological conditions, effectively avoiding the operational complexity caused by pre-mixed crosslinking agents and optimizing gel performance. The resulting hydrogel exhibits significantly improved mechanical and adhesive properties. In vitro cell experiments and in vivo animal experiments show that this sprayable hydrogel can effectively promote cell proliferation and migration, effectively maintain macrophage mitochondrial dysfunction caused by ionizing radiation, and possesses good antioxidant and anti-inflammatory activities, demonstrating broad application prospects in the repair and treatment of radiation dermatitis.

The invention relates to an anti-immunological rejection FK506 (at) ZIF-8 / HTCC ophthalmic gel and a preparation method thereof, FK506 and a zeolite imidazole skeleton (ZIF-8) are combined to prepare FK506 loaded nanoparticles (FK506 (at) ZIF-8), and quaternized chitosan is innovatively used as a sol of the FK506 (at) ZIF-8 to prepare the ophthalmic gel for use. The problems that a novel potent immune preparation tacrolimus administration mode is short in drug retention time, fast in metabolism, poor in cornea permeability and insoluble in water, and consequently the bioavailability of the FK506 eye drops is low are solved. Compared with an FK506 direct administration mode, the administration mode of the novel nanoparticle drug-loaded ophthalmic gel is higher in drug utilization rate, has a treatment effect on corneal transplantation immunological rejection, and delays the occurrence and development of transplantation rejection.