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Method for preparing quaternized chitosan nano iodine disinfectant

A technology of quaternized chitosan and disinfectant, which is applied in pharmaceutical formulations, topical antibacterial agents, active ingredients of iodine compounds, etc., can solve the problems of short residence time, small amount of iodine complexation, easy loss of iodine, etc., and achieve stable Good performance, enhanced antibacterial, easy to use effect

Inactive Publication Date: 2014-04-16
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these complexes have a small amount of iodine complexing, poor dispersion, unstable iodine is easy to lose, and when in contact with the skin, they are highly irritating to the skin, especially the wound, and the iodine stays in the skin or the wound for a short time.

Method used

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Examples

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Embodiment 1

[0032] A method for preparing quaternized chitosan nano-iodine disinfectant, comprising the following steps:

[0033] (1) Add chitosan with a viscosity-average molecular weight of 200,000 to isopropanol solvent, add sodium hydroxide solution with a mass fraction of 30%, alkalinize at 40°C for 2 hours, and slowly add diethylaminochloroethane salt dropwise Acid acid solution, the molar ratio of chitosan and quaternary ammonium salt monomer is 1:3, stir and react at 40°C for 6h, filter after the reaction is completed, adjust the pH of the filtrate to 7.0 with 10% hydrochloric acid, add 3 times The volume ratio of the filtrate volume is a mixture of ethanol and ether of 2:1, let it stand for 8 hours, precipitate and filter with suction to obtain a quaternized chitosan derivative;

[0034](2) Dissolving elemental iodine in the potassium iodide solution with a mass ratio of 1:0.8, adjusting the pH between 3.5 and 6.5 with a 1% hydrochloric acid solution with a mass fraction, and add...

Embodiment 2

[0036] A method for preparing quaternized chitosan nano-iodine disinfectant, the method may further comprise the steps:

[0037] (1) Add chitosan with a viscosity-average molecular weight of 100,000 to tert-butanol, add a sodium hydroxide solution with a mass fraction of 20%, alkalinize at 60°C for 3 hours, and then slowly add trichlorodihydroxypropyl Trimethylammonium chloride solution, the molar ratio of chitosan and quaternary ammonium salt monomer is 1: 5, react at 60°C for 4h, filter after the reaction is completed, and the filtrate is adjusted to pH with 10% hydrochloric acid with mass fraction 7.0, adding 3 times the volume of the filtrate volume is a mixed solution of ethanol and ether with a volume ratio of 2:1, let stand for 12 hours, precipitate and filter with suction to obtain a quaternized chitosan derivative;

[0038] (2) Dissolving elemental iodine in potassium iodide solution with a mass ratio of 1:1.2, adjusting the pH between 3.5 and 6.5 with 5% acetic acid ...

Embodiment 3

[0043] A method for preparing quaternized chitosan nano-iodine disinfectant, the method may further comprise the steps:

[0044] (1) Add chitosan with a viscosity-average molecular weight of 300,000 to chloroform, add a sodium hydroxide solution with a mass fraction of 30%, alkalinize at 50°C for 2.5 hours, and then slowly add diethylaminochloroethane dropwise Hydrochloride, wherein, the molar ratio of chitosan and diethylamino ethyl chloride hydrochloride is 1: 4, react at 50 ℃ for 5h, filter after completion of the reaction, and the filtrate is 10% hydrochloric acid to adjust pH to 7.0, add 3 times the volume of the filtrate and a mixed solution of ethanol and ether with a volume ratio of 2:1, let stand for 10 h, precipitate and filter with suction to obtain a quaternized chitosan derivative;

[0045] (2) Dissolving elemental iodine in a potassium iodide solution with a mass ratio of 1:1, adjusting the pH between 3.5 and 6.5 with 5% acetic acid in mass fraction, adding 1% he...

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Abstract

The invention relates to a method for preparing quaternized chitosan nano iodine disinfectant, and hydroxy or amino of chitosan or chitosan with low molecular weight are respectively connected with quaternary ammonium salt monomers, and a quaternized chitosan derivative or a quaternized chitosan derivative with low molecular weight is prepared, and the original biological activity of chitosan is still maintained in the derivative, and simultaneously solubilities of the product in water and other solvents are increased; the quaternized chitosan derivative or quaternized chitosan derivative with low molecular weight are reacted with iodine for generating chitosan group nano iodine compound or low molecular weight chitosan group nano iodine compound, and the chitosan group nano iodine disinfectant or low molecular weight chitosan group nano iodine disinfectant is prepared by dissolving in solvent. Compared with the prior art, the iodine has good dispersibility and stability in the invention, and because of surface effect and subsize effect of chitosan group nano iodine, bacteriostasis, antiviral activity and continuity of the product are improved, and effective utilization rate of iodine is increased.

Description

technical field [0001] The invention relates to a preparation method of a nanocomposite of chitosan derivatives and elemental iodine, in particular to a method for preparing a quaternized chitosan nano-iodine disinfectant, which belongs to the field of biomedical materials. Background technique [0002] Iodine itself not only has strong bactericidal properties, but also has special functions such as adsorption, oxidation, anti-virus and DNA interaction. However, because iodine is easy to sublimate, iodine is usually compounded with various substrates to improve its stability. Traditional iodine compounds such as povidone iodine, iodophor, tincture of iodine, and Aner iodine, etc. However, these complexes have a small amount of iodine complexing, poor dispersion, unstable iodine is easy to lose, and when in contact with the skin, they are highly irritating to the skin, especially the wound, and the iodine stays in the skin or the wound for a short time. Therefore, how to mak...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K31/722A61K47/48C08B37/00A61P17/00A61P31/02
Inventor 丁德润唐阳赛民泽钟士亮
Owner SHANGHAI UNIV OF ENG SCI
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