372results about "Iodine compound active ingredients" patented technology

Effective and economical compositions and methods are disclosed for the treatment, and prevention of diseases and disorders associated with inflammation and / or damage to the gastrointestinal tract, including environmental enteric dysfunction. Compositions are provided comprising a synergistic combination of colostrum, immune egg, and optionally one or more additional active agents.

Disclosed in the present application is an iodine contrast agent composition, comprising an iodine contrast agent, ethanol and water. On the basis of the volume of the pharmaceutical composition, the content of the iodine contrast agent is 208-624 mg / mL, and the content of the ethanol is 484-677 mg / mL. The composition has good effects on vascular embolization and in vivo and in vitro imaging, can meet the clinical requirements of image visualization, is clear and uniform in solution and good in stability, and has a good safety, low irritation, and little influence on tissues surrounding a focus.

A trace element solution comprises at least the following metals: zinc; manganese; selenium; and copper; and which comprises a concentration of the metals of at least 90 mg / ml. The solution may comprise the following concentrations: at least 60 mg / ml zinc; at least 10 mg / ml manganese; at least 5 mg / ml selenium; and at least 15 mg / ml copper. The solution may comprise chromium, iodine and chromium.

A method of lamellar corneal graft implantation is disclosed herein. The method includes the steps of: (i) forming one or more intrastromal incisions in a cornea of an eye of a patient; (ii) removing a cut portion of the cornea defined by the one or more intrastromal incisions from the eye of the patient; (iii) applying laser energy to a lamellar corneal graft using an excimer laser so as to modify the refractive power of the lamellar corneal graft, the lamellar corneal graft being in the form of a autologous corneal graft or a homologous corneal graft; and (iv) implanting the lamellar corneal graft into the eye of the patient in a location previously occupied by the cut portion of the cornea so as to correct the refractive power of the eye of the patient.

The preparation method comprises the following steps: grinding an iodine block to obtain iodine powder, adding the iodine powder into double distilled water, and carrying out ultrasonic stripping to obtain an iodine nanosheet suspension; under the conditions of stirring and water bath heating, dissolving polyvinyl alcohol with double distilled water to obtain a polyvinyl alcohol solution, adding sodium alginate in batches, and continuously stirring in a water bath to obtain a moldable composite hydrogel precursor solution; dissolving tannic acid by adopting an iodine nanosheet suspension, then adding into the moldable composite hydrogel precursor solution, uniformly stirring at room temperature, adjusting the pH value of the solution to be neutral, finally dropwise adding a borax solution, and stirring into gel to obtain the I2 / PBST moldable antibacterial composite hydrogel. The prepared composite hydrogel not only can play an antibacterial role and reduce the bacterial infection probability of infection sites, but also has excellent properties such as plasticity, stretchability, self-healing property, adhesion and degradability, is convenient to fill defect parts with different shapes, and is firm in adhesion.

The present invention belongs to the technical field of food. Specifically, disclosed are a nutritional composition, a preparation method therefor, and the use thereof. The nutritional composition is prepared from the following raw materials in parts by weight: 257-295 parts of protein substances, 383-395 parts of fat substances, 632-770 parts of carbohydrate, 58-60 parts of dietary fiber substances, 4.7-5.6 parts of complex trace minerals, 106 to 119 parts of complex macro minerals, 10.7 to 12.9 parts of complex vitamin, 6.21 to 7.62 parts of choline bitartrate, 0.986 to 1.1 parts of L-carnitine, and 0.42 to 0.762 part of taurine. The present invention relates to the nutritionally comprehensive and reasonably-mixed nutritional composition, which can comprehensively supplement people of low immunity with nutrients required by bodies, so as to achieve the purposes of regulating body functions, boosting immunity, strengthening bones, ameliorating constipation, promoting the recovery of the body functions and improving life quality.

The invention discloses insect-expelling traditional Chinese medicine extract trace element vitamin sustained-release pills for ruminants, and belongs to the technical field of cultivation, the insect-expelling traditional Chinese medicine extract trace element vitamin sustained-release pills comprise insect-expelling pills for releasing insect-expelling traditional Chinese medicines, counterweight pills, a digestion corrosion resistant shell for preventing the sustained-release pills from being quickly dissolved and released, and the insect-expelling pills are embedded in the inner wall of the digestion corrosion resistant shell. The counter weight pill is embedded in the inner wall of one end of the digestion corrosion resisting shell, and the parasite expelling pill comprises the following raw materials: parasite expelling traditional Chinese medicine extract, trace elements, vitamins and extrusion forming materials. The parasite-expelling traditional Chinese medicine extract is prepared by mixing one or more of szechwan chinaberry fruit, azedarach, Chinese torreya, smoked plum, quispualis indica, radix stemonae, betel nut, stone-like omphalia, rhizoma dryopteris crassirhizomae, wild carrot fruit, radix euphorbiae lantu and pumpkin seed according to any proportion. The purpose of expelling parasites for cattle and sheep for 6-9 months can be achieved by feeding the cattle and sheep with sustained-release pills, meanwhile, the requirements of microelements and vitamins are met, the problem of drug resistance is avoided, drug residues are avoided, and the method is labor-saving, safe and environment-friendly.

The use of type 2 iodothyronine deiodinase (D2) inhibitor compounds in the therapeutic treatment of muscle wasting and / or muscle and / or skin regeneration therapy is described. Pharmaceutical compositions comprising type 2 iodothyronine deiodinase (D2) inhibitor compounds in a pharma- ceutical acceptable carrier, and in combination with optional excipients, diluents and adjuvants, are also described.

This patent discloses a dual targeting lipid-based formulation designed for precise drug delivery to the thyroid gland, addressing the complexities of thyroid disorders. The formulation integrates two key technologies: the RGDFK Targeting Motif and Iodine Coupling. The RGDFK motif enhances specific binding to αvβ3 integrin receptors, facilitating internalization of therapeutic agents. Simultaneously, the Iodine Coupling technology leverages the thyroid gland's natural affinity for iodine, ensuring increased accumulation of lipid-based vesicles in thyroid tissue. Applications of this formulation extend to targeted treatment of diverse thyroid disorders, symptom-specific relief, and nutritional supplementation. The formulation serves as a fundamental component in pharmaceutical compositions, adaptable for various administration routes. The manufacturing process emphasizes scalability, reproducibility, and standardized quality. A comprehensive treatment kit has been devised, offering a convenient and tailored approach to thyroid drug delivery. In conclusion, this dual targeting lipid-based formulation signifies a paradigm shift in thyroid disorder therapeutics, promising precision, efficacy, and patient-centric care. As it advances towards clinical applications, it holds the potential to redefine the landscape of thyroid health management for enhanced patient outcomes.

To provide an antibody that binds to GARP and is useful as a therapeutic agent for a tumor, and a method for treating a tumor using the antibody, specifically to provide an antibody which inhibits the function of Treg in a tumor, making it useful as a pharmaceutical product having therapeutic effects, and a method for treating a tumor using the antibody.SOLUTION: The present invention provides an anti-GARP antibody that binds to GARP and exhibits Treg function inhibitory activity and ADCC activity, and a pharmaceutical composition comprising the antibody and used in tumor therapy.SELECTED DRAWING: None

The invention discloses a novel application of a kudzuvine root powder-based iodine complex in preparation of a medicine for preventing or treating hyperthyroidism. Experimental research shows that compared with a traditional iodine preparation, the radix puerariae powder-based iodine compound can achieve effective loading and stable wrapping of iodine and can effectively reduce the concentration of free iodine, so that the direct stimulation and injury risk of iodine to gastrointestinal mucosa is greatly reduced, the tolerance and compliance of patients taking medicine for a long time are remarkably improved, and the curative effect is good. The medicine is suitable for long-term health management of hyperthyroidism patients, and a novel treatment choice which is safe, stable, convenient and good in tolerance is provided for long-term medicine intervention of hyperthyroidism.

A composition of food or therapeutic and other substances for administration as a cloud of droplets, the cloud comprising readily-soluble droplets having a median size range of approximately 3 microns to approximately 20 microns, or 5 microns to 10 microns, or 6 microns to 10 microns, for introduction to an animal via an ortho-nasal or retro-nasal route. Agonists or antagonists may include one or more of the following: sodium iodide, sodium chloride, magnesium chloride, capsaicin, piperine, linalool, ground cinnamon, a cannabinoid, pimento, onion, clove, thyme, ginger, menthol, or TRPV antagonists, and chocolate, Irish cream, caramel, lemon, lime, mango, raspberry, watermelon, blueberry, strawberry, mint, popcorn, meat, Resolvin D2 or nicotine. Devices for delivering compositions as an aerosol are described.

Compositions for treating inflammatory skin conditions are described. The compositions can include povidone iodine in aqueous solution, hydrocortisone, diphenhydramine, an emulsifier, and a hydrophobic carrier, where the povidone iodine aqueous solution is emulsified in the hydrophobic carrier. A method of preparing a composition is also described. The method can include adding an aqueous solution of povidone iodine to a hydrophobic carrier, and adding an emulsifier to the hydrophobic carrier at a concentration that emulsifies the aqueous solution of povidone iodine in the hydrophobic carrier upon mixing.

To provide cancer treatment methods that are highly safe, enhance the therapeutic effect of cancer, and can prevent cancer metastasis and recurrence, and to provide monitoring methods for determining the therapeutic effect of PPAR-γ agonist in cancer patients.SOLUTION: Provided is a cancer treatment method that comprises a first analysis step of analyzing the peripheral blood circulation tumor cells (CTC) of a mammalian subject, a step of administering an effective amount of PPAR-γ agonist to a subject in need of treatment based on the results of the above analysis, and a second analysis step of analyzing the peripheral blood circulating tumor cells (CTC) of the subject after administration of the PPAR-γ agonist.SELECTED DRAWING: Figure 1

To improve the foamability of a disinfectant composition.SOLUTION: A disinfectant composition contains an alcohol, an iodine agent, and an anionic surfactant, the alcohol content of more than 0.495 mass% and less than 9.9 mass%.SELECTED DRAWING: None

The present invention provides an expanded feed for preventing and treating enteritis in Chinese giant toads. The present invention also provides a method for preparing an expanded feed for preventing and treating enteritis in Chinese giant toads. The present invention further provides the use of the above feed as a feed for preventing and treating enteritis in Chinese giant toads. The expanded feed for preventing and treating enteritis in Chinese giant toads provided by the present invention and the preparation method thereof can effectively improve the feeding rate and growth rate of Chinese giant toads, reduce the occurrence of enteritis, improve the survival rate, and reduce the risks and costs in the breeding process.

Provided herein are methods for providing personalized nutritional supplementation to a subject. Also provided are compositions of personalized nutritional supplementation for subjects in need thereof.

Nutraceutical food supplement for treatment of young women in post-puberty age suffering from polycystic ovary syndrome with symptoms like irregular menstruation cycles, insulin resistant diabetes, infertility, hair loss, acne and weight gain is provided. Formulations having myo-inositol and its D-chiro isomer along with plant proteins, a carbohydrate (inulin) and other plant fibres; along with well-defined proportions of vitamins (A, B1 to 6; B12 and C); several minerals like Ca, Cr, Fe, K, Mg, Mn, Na and Zn and essential amino acids like L-Glutamine, L-Lysine, and L-Taurine are provided.

The invention provides a pharmaceutical composition for treating liver cancer through arterial embolism, the pharmaceutical composition is composed of iodine oil and tirapazamine-loaded nano-vesicles, and the tirapazamine-loaded nano-vesicles comprise nano-vesicles and tirapazamine coated in the inner cores of the nano-vesicles. The invention also provides a preparation method and application of the pharmaceutical composition for treating liver cancer by arterial embolism, the preparation method comprises the following steps: performing liver left artery microcatheter hyperselection on a test rabbit VX2 liver cancer model through in-vivo test, then confirming tumor responsible blood vessels by radiography, and then applying the iodophol and tirapazamine-loaded nano-vesicle compound for embolism until thorough embolism is realized, thereby obtaining the pharmaceutical composition for treating liver cancer by arterial embolism. According to the present invention, the application of the iodophol and the tirapazamine-loaded nano-vesicle compound in the treatment of liver cancer by TAE is safe and effective, the combination with TAE provides the strong synergistic anti-tumor effect, and the TPZ can be promoted to the deep tumor under the action of the UTMD so as to induce the apoptosis of the hypoxia tumor cells;

To provide a compound comprising a cyclic peptide and a chelator, and its use.SOLUTION: The present invention provides a compound selected from the group consisting of compound Hex-[Cys(tMeBn(DOTA-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH (3BP-3554) and compound Hex-[Cys(tMeBn(DOTA-PP))-Pro-Pro-Thr-Gln-Phe-Cys]-Asp-NH2 (3BP-3407).SELECTED DRAWING: None

The invention discloses a copper-iodine cluster nano scintillator and a preparation method and application thereof.The copper-iodine cluster nano scintillator is modified with targeting molecules and a photosensitizer, the photosensitizer comprises ethidium bromide EB or indocyanine green ICG and can have high enrichment efficiency at a tumor site, and a copper-iodine cluster achieves radiation-induced fluorescence under 2Gy low-dose X-ray irradiation, so that the enrichment efficiency of the copper-iodine cluster nano scintillator is improved, and the enrichment efficiency of the copper-iodine cluster nano scintillator is improved. According to the copper-iodine cluster nano scintillator, X-ray induced photodynamic therapy is achieved, copper ions and iodide ions are released through copper-iodine cluster decomposition in a tumor environment, then copper death and iodine induced death occur, effective inhibition of cancer cells is achieved, and the copper-iodine cluster nano scintillator can achieve the high inhibition rate under low-dose X-ray irradiation and can be used for preparing a tumor inhibitor.

To provide food compositions and the like for inhibiting protein glycation that exhibit excellent anti-glycation properties, particularly, protein glycation inhibitors that exhibit anti-glycation properties against a wide range of advanced glycation end products, have antioxidant properties, and are resistant to coloring when used in cosmetics and the like, and are highly safe and biocompatible.SOLUTION: Provided is a protein glycation inhibitor characterized in that the constituent amino acids are selected from the group consisting of acidic amino acids, basic amino acids, hydroxy amino acids, branched-chain amino acids, and antioxidant amino acids, and that the constituent amino acid on the C-terminus side contains a dipeptide or a salt thereof, which is an antioxidant amino acid, as an active ingredient.SELECTED DRAWING: None

The invention discloses a high-stability povidone-iodine preparation, including polyvinylpyrrolidone K30 15.0%-25.0%, refined iodine 10.0%-12.0%, ethanol 20.0%-30.0%, potassium iodide 2.0-4.0%, organic acid 0.1-1.0%, organic acid salt 0.1-2.0%, surfactant 1.0%-3.0%, stabilizer 1.0%-5.0%, and the rest is water. Compared with the prior art, the invention has the beneficial effects that the povidone-iodine preparation obtained by the invention has good stability, low reaction temperature during the reaction, short total reaction time (only 4h-6h), high iodine yield (low degradation rate), can improve production efficiency, and reduce production energy consumption.

The invention belongs to the field of pharmaceutical preparations, and relates to a multi-trace element injection and a preparation method thereof. The multi-trace element injection comprises effective components, a stabilizer and water, the effective components comprise chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide and sodium fluoride, and the stabilizer comprises xylitol, a pH regulator and an additive; and the additive is PEG (Polyethylene Glycol) 400 or PEG 600. The multi-trace element injection provided by the invention can effectively inhibit the loss of iodine in the sterilization process, and the stability, economical efficiency and production controllability of the multi-trace element injection are fundamentally improved.

Injectable compositions that can be added to parenteral nutrition are provided. In particular, a stable injectable composition is provided which includes water, and at least one of about 800 μg to about 4,000 μg of zinc, about 40 μg to about 400 μg of copper, from about 4 μg to about 90 μg of selenium, or from about 1 μg to about 80 μg of manganese per 1 mL of the injectable composition. Methods of preparing and using of the stable injectable composition are also provided.

To provide a mouthwash mixed with povidone iodine (PVPI), containing PVPI in a higher concentration than a conventional product (7%), and to provide a method for producing the same.SOLUTION: A method for producing a povidone-iodine-containing mouthwash containing povidone iodine in an amount of 10% by mass or more based on the total amount (100% by mass) of the mouthwash, the method comprising the steps of: 2.14 4.28, A method for producing a gargle, comprising the steps of: dispersing PVPI in PG to obtain a dispersion; and mixing the dispersion with a mixed solution a1 in which at least one selected from the group consisting of ethanol, glycerin, D-sorbitol solution (70%), saccharin sodium, and 1-menthol is dissolved in water, or a mixed solution a1 in which potassium iodine is further dissolved in the mixed solution a2.SELECTED DRAWING: None

The invention discloses a novel liquid-holding particle type iodine-loaded antibacterial agent-ionic liquid gel iodine-loaded microsphere preparation method, which comprises the following steps: by taking polymethyl methacrylate as a network, a hydrophobic ionic liquid as a dispersion medium, methyl methacrylate as a monomer and azodiisobutyronitrile as an initiator, embedding molecular iodine in situ in the network, and preparing the novel liquid-holding particle type iodine-loaded antibacterial agent-ionic liquid gel iodine-loaded microsphere. The ionic liquid gel iodine-loaded microspheres are prepared. The ionic liquid cation imidazolyl group in the microbial agent can vertically act on a phospholipid bilayer on a bacterial cell membrane, and the hydrophobic end can destroy the complete structure of the cell membrane due to electrostatic interaction, so that substances outside the cell enter the cell or substances inside the cell leak out, and the cell is inactivated. Meanwhile, surface iodine in the ionic liquid gel iodine-loaded microspheres has an antibacterial effect, and the ionic liquid gel iodine-loaded microspheres and the surface iodine jointly inhibit growth of bacteria. The novel liquid-holding particle type iodine-loaded antibacterial agent-ionic liquid gel iodine-loaded microsphere is a novel solid-liquid composite polymer antibacterial material, and has the characteristics of simple preparation method, wide application range, excellent antibacterial performance and the like.

The highly stable heavy metal removal composition, its use, dosage form and manufacturing method belong to the field of pharmaceutical technology. The composition comprises (A) 70 to 95% by weight of a compound of formula (1) or a pharmaceutically acceptable salt thereof, (B) 1 to 25% by weight of a compound of formula (2) or a pharmaceutically acceptable salt thereof, and 0.001 to 5% by weight of a basic compound which is at least one of an alkali metal hydroxide, carbonate, bicarbonate, hydrogen phosphate, carboxylate or aqueous ammonia. The stability of the composition obtained by the present invention is greatly improved. While maintaining an excellent heavy metal removal effect, the dosage can be reduced to about 1 / 4 of the original amount without changing the effect of the drug. At the same time, the safety of pharmaceutical use is improved, and the stability of the pharmaceutical is improved, so that the costs of production, transportation and storage are effectively reduced, the expiration date is extended, and the cost of the pharmaceutical is effectively reduced.

The invention relates to the technical field of medical, dental or dressing preparations, in particular to intactin type enteral nutrition powder and a preparation method thereof. The powder comprises the following raw materials in parts by weight: 12-20 parts of protein, 15-25 parts of fat, 55-65 parts of carbohydrate, 5-10 parts of dietary fibers, 2-5 parts of low-methoxyl pectin, 1-3 parts of composite vitamins, 2-4 parts of minerals, 0.1-1 part of an emulsifier, 0.001-0.005 part of modified gallic acid and 50-80 parts of water. The invention also provides a preparation method of the composition. The intacted protein type enteral nutrition powder prepared by the invention is comprehensive in nutrition, balanced in proportion and convenient to use, not only has a positive effect on improving the nutritional status of a patient, but also can reduce the risk of diarrhea.

Agents, kits, and methods that utilize oxygenation to treat Inflammatory Bowel Disease (IBD) and / or provide prophylaxis against exacerbation of IBD are provided. In several embodiments, the agents, kits, and methods according to several embodiments generate in, or carry to, oxygen in the intestinal lumen to treat IBD and provide prophylaxis against exacerbation of IBD, including those caused by the presence of anaerobic bacteria in the intestine. The agents, kits, and methods provided herein generate an aerobic environment within the intestine to alleviate intestinal inflammation.