180results about "Iodine compound active ingredients" patented technology

A method of lamellar corneal graft implantation is disclosed herein. The method includes the steps of: (i) forming one or more intrastromal incisions in a cornea of an eye of a patient; (ii) removing a cut portion of the cornea defined by the one or more intrastromal incisions from the eye of the patient; (iii) applying laser energy to a lamellar corneal graft using an excimer laser so as to modify the refractive power of the lamellar corneal graft, the lamellar corneal graft being in the form of a autologous corneal graft or a homologous corneal graft; and (iv) implanting the lamellar corneal graft into the eye of the patient in a location previously occupied by the cut portion of the cornea so as to correct the refractive power of the eye of the patient.

This patent discloses a dual targeting lipid-based formulation designed for precise drug delivery to the thyroid gland, addressing the complexities of thyroid disorders. The formulation integrates two key technologies: the RGDFK Targeting Motif and Iodine Coupling. The RGDFK motif enhances specific binding to αvβ3 integrin receptors, facilitating internalization of therapeutic agents. Simultaneously, the Iodine Coupling technology leverages the thyroid gland's natural affinity for iodine, ensuring increased accumulation of lipid-based vesicles in thyroid tissue. Applications of this formulation extend to targeted treatment of diverse thyroid disorders, symptom-specific relief, and nutritional supplementation. The formulation serves as a fundamental component in pharmaceutical compositions, adaptable for various administration routes. The manufacturing process emphasizes scalability, reproducibility, and standardized quality. A comprehensive treatment kit has been devised, offering a convenient and tailored approach to thyroid drug delivery. In conclusion, this dual targeting lipid-based formulation signifies a paradigm shift in thyroid disorder therapeutics, promising precision, efficacy, and patient-centric care. As it advances towards clinical applications, it holds the potential to redefine the landscape of thyroid health management for enhanced patient outcomes.

The invention discloses a novel application of a kudzuvine root powder-based iodine complex in preparation of a medicine for preventing or treating hyperthyroidism. Experimental research shows that compared with a traditional iodine preparation, the radix puerariae powder-based iodine compound can achieve effective loading and stable wrapping of iodine and can effectively reduce the concentration of free iodine, so that the direct stimulation and injury risk of iodine to gastrointestinal mucosa is greatly reduced, the tolerance and compliance of patients taking medicine for a long time are remarkably improved, and the curative effect is good. The medicine is suitable for long-term health management of hyperthyroidism patients, and a novel treatment choice which is safe, stable, convenient and good in tolerance is provided for long-term medicine intervention of hyperthyroidism.

Provided herein are methods for providing personalized nutritional supplementation to a subject. Also provided are compositions of personalized nutritional supplementation for subjects in need thereof.

Nutraceutical food supplement for treatment of young women in post-puberty age suffering from polycystic ovary syndrome with symptoms like irregular menstruation cycles, insulin resistant diabetes, infertility, hair loss, acne and weight gain is provided. Formulations having myo-inositol and its D-chiro isomer along with plant proteins, a carbohydrate (inulin) and other plant fibres; along with well-defined proportions of vitamins (A, B1 to 6; B12 and C); several minerals like Ca, Cr, Fe, K, Mg, Mn, Na and Zn and essential amino acids like L-Glutamine, L-Lysine, and L-Taurine are provided.

To provide a compound comprising a cyclic peptide and a chelator, and its use.SOLUTION: The present invention provides a compound selected from the group consisting of compound Hex-[Cys(tMeBn(DOTA-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH (3BP-3554) and compound Hex-[Cys(tMeBn(DOTA-PP))-Pro-Pro-Thr-Gln-Phe-Cys]-Asp-NH2 (3BP-3407).SELECTED DRAWING: None

The invention belongs to the field of pharmaceutical preparations, and relates to a multi-trace element injection and a preparation method thereof. The multi-trace element injection comprises effective components, a stabilizer and water, the effective components comprise chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide and sodium fluoride, and the stabilizer comprises xylitol, a pH regulator and an additive; and the additive is PEG (Polyethylene Glycol) 400 or PEG 600. The multi-trace element injection provided by the invention can effectively inhibit the loss of iodine in the sterilization process, and the stability, economical efficiency and production controllability of the multi-trace element injection are fundamentally improved.

To provide a mouthwash mixed with povidone iodine (PVPI), containing PVPI in a higher concentration than a conventional product (7%), and to provide a method for producing the same.SOLUTION: A method for producing a povidone-iodine-containing mouthwash containing povidone iodine in an amount of 10% by mass or more based on the total amount (100% by mass) of the mouthwash, the method comprising the steps of: 2.14 4.28, A method for producing a gargle, comprising the steps of: dispersing PVPI in PG to obtain a dispersion; and mixing the dispersion with a mixed solution a1 in which at least one selected from the group consisting of ethanol, glycerin, D-sorbitol solution (70%), saccharin sodium, and 1-menthol is dissolved in water, or a mixed solution a1 in which potassium iodine is further dissolved in the mixed solution a2.SELECTED DRAWING: None

The invention discloses a novel liquid-holding particle type iodine-loaded antibacterial agent-ionic liquid gel iodine-loaded microsphere preparation method, which comprises the following steps: by taking polymethyl methacrylate as a network, a hydrophobic ionic liquid as a dispersion medium, methyl methacrylate as a monomer and azodiisobutyronitrile as an initiator, embedding molecular iodine in situ in the network, and preparing the novel liquid-holding particle type iodine-loaded antibacterial agent-ionic liquid gel iodine-loaded microsphere. The ionic liquid gel iodine-loaded microspheres are prepared. The ionic liquid cation imidazolyl group in the microbial agent can vertically act on a phospholipid bilayer on a bacterial cell membrane, and the hydrophobic end can destroy the complete structure of the cell membrane due to electrostatic interaction, so that substances outside the cell enter the cell or substances inside the cell leak out, and the cell is inactivated. Meanwhile, surface iodine in the ionic liquid gel iodine-loaded microspheres has an antibacterial effect, and the ionic liquid gel iodine-loaded microspheres and the surface iodine jointly inhibit growth of bacteria. The novel liquid-holding particle type iodine-loaded antibacterial agent-ionic liquid gel iodine-loaded microsphere is a novel solid-liquid composite polymer antibacterial material, and has the characteristics of simple preparation method, wide application range, excellent antibacterial performance and the like.

Agents, kits, and methods that utilize oxygenation to treat Inflammatory Bowel Disease (IBD) and / or provide prophylaxis against exacerbation of IBD are provided. In several embodiments, the agents, kits, and methods according to several embodiments generate in, or carry to, oxygen in the intestinal lumen to treat IBD and provide prophylaxis against exacerbation of IBD, including those caused by the presence of anaerobic bacteria in the intestine. The agents, kits, and methods provided herein generate an aerobic environment within the intestine to alleviate intestinal inflammation.

The invention refers to the compound of formula (I), or enantiomers thereof, or pharmaceutically acceptable salts thereof: (I) or a pharmaceutical composition comprising the same, for use in the treatment of a pathology characterised by the expression of the Na / I symporter (NIS) in the affected cells. The invention also relates to the same compounds of formula (I), or enantiomers thereof, or pharmaceutically acceptable salts thereof, or pharmaceutical composition comprising the same for use in an in vivo diagnostic method of a pathology characterised by the expression of the Na / I symporter (NIS) in the affected cells.

Compositions for treating inflammatory skin conditions are described. The compositions can include povidone iodine in aqueous solution, hydrocortisone, diphenhydramine, an emulsifier, and a hydrophobic carrier, where the povidone iodine aqueous solution is emulsified in the hydrophobic carrier. A method of preparing a composition is also described. The method can include adding an aqueous solution of povidone iodine to a hydrophobic carrier, and adding an emulsifier to the hydrophobic carrier at a concentration that emulsifies the aqueous solution of povidone iodine in the hydrophobic carrier upon mixing.

The invention provides a method for preparing calcium-based nano particles by a reversed-phase microemulsion method, an organic calcium salt nano material and application of the organic calcium salt nano material as a nano drug, and belongs to the field of biomedical nano materials. The calcium-based nanoparticles can be formed by reacting calcium dodecyl benzene sulfonate with ammonium salt of corresponding ions or a hydroxyl-containing organic matter aqueous solution; the preparation method of the calcium-based nanoparticles has certain universality, and nano-material drugs including calcium succinate, calcium hypophosphite, calcium gluconate, calcium formate, calcium citrate and the like are successfully synthesized. The synthesis method is simple, mild in reaction condition, environment-friendly, high in repeatability, capable of realizing batch preparation and low in raw material cost. When the calcium salt nano-drug such as calcium succinate enters tumor cells through endocytosis, a large number of ions are brought into the cells, and suddenly excessive ions can cause osmotic pressure and homeostasis imbalance in the cells, activate a pyroptosis pathway of the cells and induce death of immunogenic cells.

Methods and compositions for treating various indications by lessening oxidative stress in a patient are provided. A pharmaceutical composition comprises between about 0.001% to about 10.0%, or more specifically between about 0.015% to about 5%, sodium iodide or catalase by weight. The iodine ion or the catalase dissociates hydrogen peroxide into water and molecular oxygen to interrupt biological events that result in negative side effects. The pharmaceutical composition further comprises in some cases a reducing agent or various carrier materials. The pharmaceutical composition is in some cases formulated for a variety of delivery methods.

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphosphocholine analogs are compounds having the formula:or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection / imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

The present invention relates to a pharmaceutical product for preventing or correcting selenium deficiency in a patient, comprising a solution provided in a flexible container, the solution comprising at least one selenate and / or selenoamino acid, such as selenomethionine and / or selenocysteine.

Assemblies, systems, and kits for use in a TTField-generating system are disclosed that include a conductive hydrogel or conductive adhesive in combination with a coating comprising, or formed from, an iodine solution. Also disclosed are methods of producing and using the assemblies, systems, and kits. Further disclosed are methods of applying an iodine solution, a conductive hydrogel or conductive adhesive, and a TTField-generating system to the skin of a subject.

Dietary supplement compositions and methods of use thereof in subjects who are pregnant, trying to become pregnant, nursing and / or lactating are provided.

The invention discloses a pharmaceutical composition for delaying senescence and resisting oxidation, and belongs to the technical field of biological medicine and health food. The composition comprises vitamin A, beta-carotene, vitamin complex B, vitamin C, vitamin D, vitamin E, vitamin k, macroelements including calcium, phosphorus, potassium and magnesium, microelements including zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese, traditional Chinese medicines including ginseng, astragalus membranaceus, fructus lycii and radix polygoni multiflori preparata, and condition essential nutrient nucleic acid. The bioactive components comprise lycopene, tea polyphenol, taurine, lutein, lutein fat, zeaxanthin, chlorophyll and the like; is mainly suitable for middle-aged and elderly people; the composition eliminates multiple factors causing aging from multiple systems, multiple links and multiple targets, can significantly delay aging, has health-care and tonifying effects such as oxidation resistance, and can improve the life quality of middle-aged and elderly people while delaying aging; the composition has no incompatibility, and does not generate any toxic or side effect after being taken for a long time.

The application discloses a stable liver cancer embolism emulsion of raltitrexed drug gel and a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The emulsion is composed of iodized oil embolism agent and raltitrexed drug gel; the raltitrexed drug gel is a nanofiber network hydrogel formed by self-assembly of raltitrexed molecules in an aqueous phase through ultrasonic treatment, and simultaneously serves as an active pharmaceutical ingredient and an emulsion stabilizer. The iodized oil and the raltitrexed drug gel are physically mixed and injected through a three-way valve to form a stable oil-in-water emulsion or a water-in-oil emulsion, and any additional chemical surfactant or cosolvent is not needed. The emulsion has excellent physical stability, and can effectively solve the problems of easy aggregation and sedimentation of a traditional iodized oil emulsion and increased systemic toxicity caused by drug burst release. The emulsion has good embolism effect and drug release behavior, can significantly inhibit tumor growth, and has a wide clinical transformation prospect.

Described herein are method and kits for locally treating or preventing infection in a patient in need thereof. The method may include locally administering to a human patient a plurality of doses of at least one antiseptic agent in solution by irrigating the at least one antiseptic agent at a wound, wherein the administration provides the patient continuous localized antiseptic therapy for at least a 24-hour period, at least 48-hour period, at least a 72-hour period, or at least a 96-hour period.

The present application provides an iodine-containing disinfectant based on keratin and a preparation method thereof. The iodine-containing disinfectant comprises elemental iodine, keratin, a stabilizer and water. The preparation method of the iodine-containing disinfectant comprises: step 1): dissolving elemental iodine and a first stabilizer in water, then adding keratin, and then adjusting the pH to obtain a mixed solution A; step 2): adding a second stabilizer to the mixed solution A, mixing, and obtaining the iodine-containing disinfectant. In the iodine-containing disinfectant of the present application, by combining elemental iodine, a stabilizer and keratin, the iodine-containing disinfectant not only has a good bactericidal effect, but also can promote the growth of granulation tissue and accelerate wound healing.

The invention relates to a low glycemic index composition which comprises the following components in percentage by weight: 10-35% of a protein composition, 20-55% of a fat composition, 5-35% of a saccharide composition, 1-15% of a dietary fiber composition, 1-2% of a trace element composition, 0.1-1.5% of a vitamin composition and 5-20% of a macroelement composition, according to the composition with the low glycemic index, all the components are scientifically compounded, the digestion and absorption speed of carbohydrates is effectively controlled, the blood glucose level of diabetic patients or patients with impaired glucose tolerance is effectively controlled, comprehensive and balanced nutrition is provided for the diabetic patients or the patients with impaired glucose tolerance, and the composition is beneficial for repairing and improving the immunity of the diabetic patients or the patients with impaired glucose tolerance; and the feed also has the advantages of excellent quality uniformity, stability and fluidity, light taste, suitability for tube feeding and the like.

The invention discloses an autumn procambarus clarkii egg-carrying shrimp breeding facility and method, and belongs to the technical field of procambarus clarkii egg-carrying shrimp breeding. Crayfish parents are cultivated through VE nutrition enhancement, gonad development is promoted, and the physique and immunity of the parent crayfishes are enhanced; the illumination and the water temperature are reduced, the water temperature is regulated and controlled to induce the crayfishes to lay eggs and carry eggs outside the holes, and the egg laying synchronization rate of the parent crayfishes is increased and reaches about 80%; a net cage breeding facility is arranged, so that the crayfishes lay eggs outside the caves, and the crayfishes carrying eggs can be conveniently caught in a centralized mode; the square belts are spliced along the flowerpot to create a cave structure so as to provide a hidden environment for the parent shrimps; through pond bottom sludge removal before net cage arrangement, quicklime disinfection, pond bottom exposure, box body washing, water changing, microecological preparation and substrate modifier use and the like in the breeding period, substrate and water quality are kept to be good, the problems that the water quality of the net cage is prone to deterioration and the like are solved, the survival rate of seed shrimps is increased, the yield of autumn breeding egg-carrying shrimps is increased, and an egg-carrying shrimp source is provided for hatching of egg-carrying young shrimps.

The invention discloses a formula of a fermented feed for enhancing animal immune function, and relates to the technical field of fermented feeds. The formula comprises the following components in parts by mass: a basic raw material, an immune enhancement extract, a functional additive, 0.3-0.6 part of a composite microbial agent and 2-4 parts of composite mineral substances. Wherein the ganoderma lucidum extract and the folium cortex eucommiae extract activate immune cells through the synergistic effect of polysaccharide and chlorogenic acid; the complex microbial inoculant is composed of lactobacillus acidophilus, bacillus licheniformis and candida utilis according to a ratio of (5-6): (3-4): 2, efficiently degrades antinutritional factors and generates immunocompetence metabolites. The preparation process comprises the following steps: supercritical extraction of plant active components, mixing and humidifying of base materials, segmented stirring and fermentation after microbial inoculum activation, and then addition of functional components and drying. Through synergistic combination of the raw materials and process optimization, the animal immunity is remarkably improved, and the feed additive has the advantages of low cost and multiple immune enhancement mechanisms.

An improved aqueous teat dip comprising iodine and chlorhexidine in an aqueous solution.